Guia de Boston Inglés

2011 REVIEW OF

CLINICAL RESEARCH & INNOVATIONS A GUIDE TO THE AMERICAN ACADEMY OF OPTOMETRY POSTERS AND PRESENTATIONS

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The world’s first disposable contact lens ACUVUE® Brand Contact Lenses changed contact lenses forever.

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The world’s first daily disposable contact lens 1-DAY ACUVUE® Brand Contact Lenses bring comfort and convenience to millions of wearers.

PUPIL INTELLIGENT DESIGN™ ACUVUE® Brand Contact Lenses BIFOCAL feature unique technology that corrects presbyopia.

HYDRACLEAR® Technology ACUVUE® ADVANCE® Brand Contact Lenses with HYDRACLEAR® Technology offer exceptional long-lasting comfort.

BLINK STABILIZEDTM Technology ACUVUE® ADVANCE® Brand Contact Lenses for ASTIGMATISM provide a predictable, stable lens.

Introducing...

HYDRACLEAR® Plus Technology ACUVUE® OASYS® Brand Contact Lenses with HYDRACLEAR® Plus are designed to provide comfort in dry, challenging environments.

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2006

LACREON® Technology 1-DAY ACUVUE® MOIST® Brand Contact Lenses give a fresh new comfortable feeling from morning to night.

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BLINK STABILIZED™ Technology ACUVUE® OASYS® Brand Contact Lenses for ASTIGMATISM provide a predictable, stable lens.

STEREO PRECISION TECHNOLOGY™ optical design ACUVUE® OASYS® Brand Contact Lenses for PRESBYOPIA provide balanced vision for near, far and in-between.

The world’s first daily disposable silicone hydrogel 1-DAY ACUVUE® TruEyeTM Brand Contact Lenses.

World’s first daily disposable silicone hydrogel.

(Note: Launched outside the US in 2008.)

HYDRACLEAR® Technology With enhanced technology, ACUVUE® ADVANCE® Plus Brand Contact Lenses offer exceptional comfort and performance in a fresh, 2-week modality.

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Professional Development & Medical Affairs Professional Development & Medical Affairs at VISTAKON® Division of Johnson & Johnson Vision Care, Inc. continues to serve as the voice of our professional customer within our organization and is responsible for delivering technical, clinical, and educational support to the profession.

Professional Development & Medical Affairs is committed to establishing enduring partnerships with optometry students, doctors, and professional organizations through innovative education and training.

The team’s broad range of experience encompasses publishing clinical articles, presenting at symposia, and involvement in optometric education. This experience, as well as their commercial backgrounds from franchise directors to independent practice owners, helps them to provide a broad perspective from which they can draw when meeting fellow professionals.

THE VISION CARE INSTITUTE

TM

Since its inception in 2004, THE VISION CARE INSTITUTE™ has provided additional training to 1 in 5 practicing US optometrists. Our mission is to enhance patient satisfaction through innovative education for all eye care providers. We look to foster confidence in proactively providing vision care to your patients through comprehensive technical training and unique hands-on patient interaction.

THE VISION CARE INSTITUTE™ is a state-of-the-art facility located in Jacksonville, Florida that welcomes optometry students and practicing eye care professionals from all over North America.

If you would like to register for one of our classes, visit www.tvciedu.com or speak with your local VISTAKON® sales representative.

Colleen M. Riley, OD, MS, FAAO Vice President, Professional Development & Medical Affairs

6 Dr. Colleen Riley is the Vice President of Professional Development & Medical Affairs for VISTAKON® Division of Johnson & Johnson Vision Care, Inc. Dr. Riley leads the team that provides scientific and clinical expertise and focuses on professional development and support for eye care professionals. She also oversees the strategies and activities for THE VISION CARE INSTITUTE™, LLC, which provides innovative clinical, technical, and practice education. Dr. Riley joined the Research and Development team at VISTAKON® in 2004, where she played an essential role in all stages of product development. Most recently she served as Director of Design, Research and Development. Dr. Riley received her Doctor of Optometry degree along with a Master of Science in Physiological Optics from Indiana University School of Optometry. She began her career path in practice and as a faculty member at Indiana University. She is a Fellow and a Contact Lens Diplomate in the Section on Cornea, Contact Lenses and Refractive Technologies of the American Academy of Optometry, and served as a Principal Investigator in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study funded by the National Eye Institute. An accomplished speaker and author, Dr. Riley was selected as one of the Top 20 Most Influential Women in the Optical Industry in 2007.

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Sheila B. Hickson-Curran, BSc (Hons), MCOptom, FAAO, FBCLA Director, Medical Affairs

Sheila Hickson-Curran earned her optometry qualifications from the City University, London, United Kingdom. Sheila joined VISTAKON® in 1995 as a Research Optometrist, with positions of increasing responsibility in Research & Development. She is the co-inventor of BLINK STABILIZEDTM Technology, used in ACUVUE® ADVANCE® Brand Contact Lenses for ASTIGMATISM and ACUVUE® OASYS® Brand Contact Lenses for ASTIGMATISM, for which she won a Johnson Medal, the highest award for innovation in Johnson & Johnson. In her role as Director of Medical Affairs, she provides technical education for our professional customers, as well as professional insight and counsel for Brand teams. Sheila is a Fellow of the American Academy of Optometry.

Cristina M. Schnider, OD, MSc, MBA, FAAO Senior Director of Medical Affairs

Dr. Cristina Schnider is Senior Director of Medical Affairs for VISTAKON® Division of Johnson & Johnson Vision Care, Inc. From 2007 to late 2010, Dr. Schnider led the Professional and Medical Affairs team for Johnson & Johnson Vision Care Company in Japan. Dr. Schnider joined VISTAKON® in 1999, following a 14-year career in academia, with positions at the State University of New York College of Optometry, the Cornea & Contact Lens Research Unit in Sydney, Australia, and Pacific University College of Optometry. Dr. Schnider received her Doctor of Optometry degree from Pacific University College of Optometry, a Master of Science in Clinical Research from the University of New South Wales in Australia, and an MBA from the University of Florida. She is a Fellow, a Contact Lens Diplomate, and a member of the leadership team in the Section on Cornea, Contact Lenses and Refractive Technologies of the American Academy of Optometry, a council member for the International Society for Contact Lens Research, and has spoken and published in several languages on topics related to cornea and contact lenses.

Arthur Shedden, MD, MBA Director of Medical Affairs and Medical Safety Officer

Art Shedden, MD, is Director of Medical Affairs and Medical Safety Officer of VISTAKON® Division of Johnson & Johnson Vision Care, Inc. Dr. Shedden earned his medical degree from Jefferson Medical College in Philadelphia, PA. He completed his residency in ophthalmology at the University of Pittsburgh in Pittsburgh, PA and his fellowship in neuro-ophthamology at the Bascom Palmer Eye Institute at the University of Miami in Miami, FL. He earned his MBA from the Wharton School of Business at the University of Pennsylvania in Philadelphia, PA. Dr. Shedden has led teams in clinical development for ophthalmology at Merk Research Laboratories and in global medical affairs for ophthalmology at Pfizer/Pharmacia. Prior to joining VISTAKON® in 2008, he managed global medical affairs for allergy and respiratory at Schering-Plough.

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Richard Wallingford, Jr, OD, FAAO Director, Professional Affairs

Dr. Richard Wallingford is Director of Professional Affairs at VISTAKON® Division of Johnson & Johnson Vision Care, Inc. He is a past President of the American Optometric Association, serving as the President from 2005-2006. He is also the past President of the Maine Optometric Association and past President of the Maine Board of Optometry, serving eleven years by the Governors appointment. Dr. Wallingford served on an AOA committee or board continuously for 28 years.

A graduate of the New England College of Optometry, he served on their Board of Trustees for over 8 years. He is a member of the Governing Board and the Treasurer of the World Council of Optometry, and the World Optometry Foundation. He is also the Past President of the Partnership Foundation for Optometric Education. Dr. Wallingford has been in a private practice, a partnership specializing in contact lenses, and a large OD/MD practice with two ambulatory surgical suites and a Lasik center, all located in Maine. Over the years, Dr. Wallingford has received numerous awards, but none as special as the Lifetime Distinguished Service Award from the Maine Optometric Association in 2006.

Katie Carpenter, MBA Senior Director, THE VISION CARE INSTITUTE™, LLC

Katie is Senior Director of THE VISION CARE INSTITUTE™, LLC. She also serves as General Manager, leading strategic planning, curriculum development, and alumni relations. Prior to coming to VISTAKON®, Katie worked in marketing for AstraZeneca Pharmaceuticals in the Respiratory and Oncology therapeutic areas. Prior to AstraZeneca, Katie worked for the Veterinary Pharmaceutical division of Pfizer, Inc. in marketing their antibiotic and equine portfolios along with the launch of Anipryl™.* She has also worked at several advertising agencies in the Philadelphia area for such clients as Alpo Pet Foods, Scott Paper Company, The Iams Company, Tastykake Baking Company, Sunoco Oil, and the City of Philadelphia.

Katie has her MBA from Pennsylvania State University and a BS in Communications from the University of Miami, Florida.

Aaron See, MBA 8

Director, Professional Development & Education

Aaron See is the Director of Professional Development & Education for VISTAKON® Division of Johnson & Johnson Vision Care, Inc. He has over 12 years of experience in the Global Health Care arena, where he has focused on bridging the opportunities and needs of patients and professionals. Over this time, he has worked extensively across Asia, Europe, and the Americas in the areas of analgesics, cardiovascular, and vision care. Most recently, Aaron led the Johnson & Johnson Vision Care, Inc. global introduction of 1-DAY ACUVUE® TruEye™ Brand as the world’s first daily disposable silicone hydrogel lens. Aaron is a graduate of Brandeis University with a BA in economics & international relations. He earned his Masters of Management degree from JL Kellogg Graduate School of Management, with majors in marketing, management & strategy, and entrepreneurship.

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Giovanna E. Olivares, OD, FAAO Director of Professional Education

Dr. Olivares is the Director of Professional Education at VISTAKON® Division of Johnson & Johnson Vision Care, Inc. In this role, she is responsible for the development of new and innovative educational professional programs. Dr. Olivares graduated from the State University of New York with a doctorate degree and subsequently completed a post-doctoral fellowship program in ocular disease management in affiliation at the State University of New York College of Optometry. Upon completion of her fellowship, she became an Assistant Professor at the College of Optometry, having responsibility in both didactic and clinical programs. Following her academic career, she joined Unilens Corp. USA as the Director of Professional Development and Clinical Affairs, and spent 12 years developing new presbyopic contact lenses. In 2004 she joined VISTAKON®. As the Senior Manager of Clinical Research, she led a multidisciplinary group of optometrists, biostatisticians, and vision scientists that were responsible for the development of new contact lens products such as ACUVUE® ADVANCE® for ASTIGMATISM, ACUVUE® OASYS® for ASTIGMATISM, ACUVUE® ADVANCE® Plus, and other products that have been launched throughout the world. Dr. Olivares is a Fellow of the American Academy of Optometry

Carol Alexander, OD, FAAO Director of Professional Affairs

Dr. Carol Alexander is Director of Professional Affairs for VISTAKON® Division of Johnson & Johnson Vision Care, Inc. She is responsible for the VISTAKON® Professional Affairs Consulting Team (PACs), bringing the Innovation for Healthy VisionTM campaign to practitioners through a series of peer-to-peer programs. Her primary role is to serve as liaison between the optometric community and the internal teams at VISTAKON®. In her position, she provides valuable insight regarding the mindset of the practitioner, having been in private practice for 21 years in northwest Ohio. Dr. Alexander joined VISTAKON® in 2007 and is a 1987 graduate of The Ohio State University College of Optometry. Her previous leadership roles include the Presidency of the Ohio Optometric Association and chairperson for the AOA’s Commission on Quality Assurance and Improvement. She has been honored with the AOA’s Young Optometrist of The Year Award, and subsequently with Ohio’s Optometrist of The Year Award. Dr. Alexander is a member of the California and American Optometric Associations and is a Fellow of the American Academy of Optometry.

In 2010 she was named one of Vision Monday’s Most Influential Women in Optical.

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W. Lee Ball, Jr., OD, FAAO Associate Director of Medical Affairs

W. Lee Ball, Jr., OD, is Associate Director of Medical Affairs of VISTAKON® Division of Johnson & Johnson Vision Care, Inc. Dr. Ball holds a degree in Public Health from the University of North Carolina at Chapel Hill, is a graduate of the University of Houston College of Optometry, and a Fellow of the American Academy of Optometry. He completed his Optometric residency at the University of Miami Bascom Palmer Eye Institute. After residency, Dr. Ball joined the staffs at Beth Israel Deaconess Medical Center and Joslin Diabetes Center, teaching hospitals of Harvard Medical School. Before joining VISTAKON®, Dr. Ball was an adjunct clinical faculty member at the New England College of Optometry. He is past chair of the Pharmacy, Podiatry, Optometry and Dental Health Provider (PPOD) work group for the National Diabetes Education Program (NDEP) and was named the Massachusetts Young Optometrist of the Year for 2010.

Janelle Routhier, OD, FAAO Manager of Medical Affairs

Dr. Janelle Routhier earned her doctorate of Optometry from the Michigan College of Optometry at Ferris State University in 2008 and went on to complete a Cornea and Contact Lens residency at Michigan College of Optometry. She joined the VISTAKON® team in early 2011. In her role as Manager, Medical Affairs, she is responsible for providing clinical and technical insight to the company and to professional prescribers of VISTAKON® products.

Previously, Dr. Routhier was contact lens clinical faculty at Michigan College of Optometry and also worked in private practice. She has developed and performed research in the area of toric orthokeratology and is also a Fellow of the American Academy of Optometry. She was recently named one of the first Diplomates of the America Board of Optometry in the country, after completing the board certification process in August, 2011.

Maggie Boniecka, BS Associate Product Director, THE VISION CARE INSTITUTE™, LLC

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Maggie Boniecka is Associate Product Director for THE VISION CARE INSTITUTE™, LLC. In this role she is responsible for leading strategic communication initiatives for alumni of the Institute as well as managing the Alumni Community. Prior to her current role, Maggie led professional digital marketing efforts at VISTAKON®. She also spent time at Force 3, Inc., an IT solutions company, developing recruitment and engagement programs for potential customers. Maggie graduated Cum Laude from the University of Maryland, Robert H. Smith School of Business with a BS in Marketing.

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OCTOBER 12 Room 311 3:30 PM

PRESENTATION Clinical Performance of Silver Salt-Infused Silicone Hydrogel Contact Lenses over Six Months of Daily Wear Carol Lakkis, BScOptom, PhD, PGCertOcTher, FAAO, FVCO, FBCLA Frank Anastasopoulos, MSc; Jared Slater, BScOptom; Brian Pall, OD, MS

PURPOSE: To assess the clinical and subjective performance of silver salt-infused silicone hydrogel lenses compared to standard silicone hydrogel lenses over six months of daily wear.

METHODS: A prospective, randomised, double-masked, contralateral study was conducted. Sixty subjects were randomly assigned to wear silver salt-infused (galyfilcon A with incorporated silver iodide, test) and standard (galyfilcon A, control) silicone hydrogel CLs on a contralateral basis for six months of daily wear. Study visits were conducted at 1 week, 4 weeks, 3 and 6 months following lens delivery, and included assessment of a range of objective and subjective clinical performance measures.

RESULTS: Fifty subjects completed the study. There were no discontinuations due to adverse events and no significant differences in adverse response rates between the test and control eyes (P>0.05).

The test lenses did not affect high or low contrast visual acuity, or subjective vision or comfort ratings compared to the control lenses (P>0.05). No silver deposition in the cornea or tissue colour changes were noted in any subject and no statistically significant differences between test and control lens wearing eyes were observed for all ocular health measures (P>0.05). Some significant changes over time were observed in bulbar and limbal redness (P<0.05), corneal and conjunctival staining (P<0.05) and intraocular pressure (1 mmHg decrease, P<0.05) with both lens types; however, these were not considered to be clinically significant.

CONCLUSIONS: The silver salt-infused test and control lenses performed similarly with respect to visual acuity, ocular health measures and subjective ratings when worn over six months of daily wear.

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Galyfilcon A lens formulation without (left) and with infused silver (right), challenged with Staphylococcus aureus

Dr. Carol Lakkis completed her Bachelor of Science in optometry and PhD degrees at the University of Melbourne in 1991 and 1999, respectively. She then moved to the University of California, Berkeley, School of Optometry where she held the titles of Assistant Clinical Professor and Research Scientist. Dr. Lakkis was then appointed as Director of Research of Clinical Vision Research Australia, at the Australian College of Optometry from 2002 to 2010. In August 2010 Dr. Lakkis joined VISTAKON® Division of Johnson & Johnson Vision Care, Inc. in the USA as a Clinical Research Fellow, and continues her work with Queensland University of Technology as an Adjunct Associate Professor.

Study supported by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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PRESENTATION

OCTOBER 12 Room 311 3:45 PM

One Year Follow-up of Daily Disposable Silicone Hydrogel Lens Wear vs Spectacle Wear in Neophytes Jason J Nichols, OD, MPH, PhD, FAAO, Diplomate, Contact Lens and Public Health Kathrine E Osborn, OD, MS, FAAO, FBCLA; Terri Henderson, MS; Jeffrey J Walline, OD, PhD, FAAO

PURPOSE: To compare the physiological response of the eye to daily disposable silicone hydrogel contact lens wear in neophytes over a one year period.

METHODS: This was a randomized, masked clinical trial. At baseline, neophyte subjects between 15 and 39 years of age, with a distance contact lens correction between -0.50 and -6.00 DS and less than 0.75 DC were randomly assigned to 1-DAY ACUVUE® TruEyeTM Brand Contact Lenses (narafilcon B, Johnson & Johnson Vision Care, Inc.) (n = 47) or to continue wearing their own spectacles (n = 47).

After randomization, subjects were evaluated at five additional visits occurring at 10 days (visit 2), one month (visit 3), 3 months (visit 4), 6 months (visit 5), and one year (visit 6). Among other outcomes, subjects were evaluated for ocular physiological changes using slit-lamp biomicroscopy and the Efron grading scales with responses graded from zero to four. A linear mixed model with group and visit as fixed effects and patient as a random effect was used to analyze the data using SAS 9.2.

RESULTS: Ninety four subjects were randomized (average age = 22.9 years, 50% female), and 74 subjects completed the one-year follow-up. For papillary conjunctivitis, conjunctival hyperemia, limbal hyperemia, and corneal vascularization, the contact lens and spectacle groups were equivalent through the year long period. For corneal staining, the contact lens and spectacle groups were equivalent across the year-long period, with the exception of the last visit, at which the contact lens wearers had significantly more corneal staining (mean difference = 0.39 units, 95% CI = 0.15 to 0.64). Contact lens wearers had higher average conjunctival staining at most follow-up visits ranging in difference from 0.30 to 0.91 units. There were no instances of any serious, significant, or corneal infiltrative events in either group.

CONCLUSION: For neophyte subjects wearing a daily disposable, silicone hydrogel contact lens, the physiological response of the eye is comparable to wearing spectacles, with the exception of increased conjunctival staining.

ONE YEAR PHYSIOLOGY DATA KEY MEASURES LOWER MARGIN

UPPER MARGIN

Cornea Vascularization

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Conjunctival Hyperemia Limbal Hyperemeia Corneal Staining Conjunctival Staining Papilary Conjuctivitis

-2.0

-1.5

-1.0

-0.5

Spectacles Better

0.0

0.5

1.0 TM

TruEye

1.5

2.0

(nara B) Better

Jason J. Nichols, OD, MPH, PhD, FAAO, is a Professor at the University of Houston College of Optometry, where he is responsible for teaching coursework on the tear film, dry eye, corneal physiology and contact lenses. He has received research funding from the National Eye Institute of the National Institutes of Health to study dry eye diseases including meibomian gland disease, dry eye and contact lens-related dry eye. He has also received funding from the American Optometric Foundation, in addition to a variety of industrial partners. He has authored over 70 peer-reviewed manuscripts and 130 abstracts on these topics. He is currently Editor of Contact Lens Spectrum, serves on the editorial board for Eye and Contact Lens and is also a diplomate in the American Academy of Optometry’s sections of Public Health and Environmental Optometry and Cornea, Contact Lenses, and Refractive Technology.

Study supported by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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OCTOBER 12 Room 311 4:30 PM

PRESENTATION Demonstrating Content Validity of CLUE: Contact Lens User Experience TM

Terri L Henderson, MS RJ Wirth, PhD; Michael L Henderson, MS; Colleen M Riley, OD, MS, FAAO

PURPOSE: To describe the evidence supporting content validity for the patient-reported outcomes (PRO) instrument CLUE: Contact Lens User Experience™.

METHODS: The FDA guidance and NIH roadmap initiative Patient-Reported Outcomes Measurement Information System (PROMIS) were maps for building a measurement framework. Development involved collecting patient input and satisfying saturation of the patient experience with soft, disposable contact lenses. Cognitive interviews built knowledge of patient experiences. Patient focus groups covered age ranges and lens types. An initial item bank was tested with psychologist-led interviews and finalized with instructions, recall periods and response scales. The item bank was validated in 4 phases on 1486 subjects.

RESULTS: Pre-testing led to qualitatively-recommended maximum duration of 10 minutes. Fundamental questions on response options wording and polarity of item wording were addressed. Agreement and frequency response options were tested and frequency showed a 20% lower reliability and 10% increase in standard error (SE) over the population range. Items worded both positively and negatively demonstrated a 26% reduction in reliability if negative with a 13% increase in SE. A novel approach used adjectives to modify wording strength of item stems and indicated increases in measurement capability at the extremes of patient experiences. Modifying base items with “very” demonstrated a twofold increase in reliability for the top 2.5% of the population and a 99-fold increase from base to “extremely”.

CONCLUSIONS: Through a series of rigorous experimental stages, the evidence supporting content validity of CLUETM is mapped out. The tool is optimal for use on the intended population and meets the criteria for saturation by covering the scope of everyday life with lenses. CLUETM is a true PRO instrument whose content captures the lens experience directly from the patient’s perspective.

TEST INFORMATION FUNCTION USING MODIFIERS

RELIABILITY CHANGES USING MODIFIERS

3.0

1.0 0.9 0.8 0.7

2.0 Reliability

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Information

2.5

1.5 1.0

0.6 0.5 0.4 0.3

BASE VERSION “VERY” VERSION “EXTREMELY” VERSION

0.5

0.2

BASE VERSION “VERY” VERSION “EXTREMELY” VERSION

0.1

0.0

0.0 0

20

40

60

CLUE

TM

80 Score

100

120

0

20

40

60

CLUE

TM

80

100

120

Score

Terri Henderson is a Senior Biostatistician/Patient-Reported Outcomes Lead at VISTAKON® Division of Johnson & Johnson Vision Care, Inc. She has provided biostatistics support for numerous launches of ACUVUE® Brand Contact Lenses for the past 6 years. In addition, she leads the patient-reported outcomes initiative at JJVCI, including publication plans regarding the development of CLUE: Contact Lens User Experience™, expansions and new clinical study questionnaire development.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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PRESENTATION

OCTOBER 12 Room 311 4:45 PM

Impact of Questionnaire Length on Quality of Responses Michael L Henderson, MS RJ Wirth, PhD; Terri L Henderson, MS; Kathrine Osborn, OD, MS, FAAO, FBCLA

PURPOSE: To demonstrate whether patients’ speed of responding to questionnaires is impacted by the length of the instrument. Item response theory (IRT) based scores and standard errors from the patient-reported outcomes (PRO) instrument CLUETM: Contact Lens User Experience™ will be evaluated when increasing the number of questions within domains.

METHODS: Data was collected via electronic data capture (EDC) from the patient using a kiosk designed for in-office. Four fixed forms were 81 and 85 items in length with 140 unique items. Patients answered an average of 80.9 items. There were a total of 28 comfort items per form, 34 or 40 vision items, 10 or 11 handling items and 7 or 8 packaging items. The EDC system captured the time a patient responded to an item in seconds. The time to answer an item was calculated as the time since responding to the previous item. IRT scores and standard errors were calculated as cumulative scores incorporating each additional item answered. The change in IRT score from the previous cumulative score was calculated to evaluate convergence.

RESULTS: 470 patients completed the questionnaire per protocol and three completed two questionnaires at the baseline visit. Patients spent an average of 12 seconds getting to the second item. The time to answer decreased (ie, speed up) until the 15 to 20th item, possibly due to screen clicking, and took an average of 2 minutes to reach this point. The change in cumulative IRT scores from the previous score for comfort converged after 8-10 items. The other domains had similar results.

CONCLUSIONS: A maximum of ten items is usually sufficient to obtain accurate IRT scores from a fixed instrument while the “uncertainty” (ie, standard error) increases. To ensure obtaining reliable information, the questionnaire should have the minimum number of items to obtain an accurate score, which could be obtained by extending to computer-adaptive IRT methods.

TIME TO ANSWER vs CUMULATIVE TIME SPENT ON FORM TIME TO ANSWER < 100 (38,035 EXCLUDING 17 DATA POINTS)

Time to Answer (seconds)

100 90 80 70 60

15

50 40 30 20 10 0 0

200

400

600

800

1000

1200 1400

1600

1800

Cumulative Time (seconds)

Michael Henderson is the Manager of Biostatistics for VISTAKON® Division of Johnson & Johnson Vision Care, Inc. based in Jacksonville, Florida. He has over 10 years of experience with the design and analysis of clinical trials for contact lens development. Over this time, he has worked extensively with the science of patient-reported outcomes including the development of new survey instruments for contact lens users. He has a BS in Mathematics and MS in Statistics from the University of Georgia.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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10/26/11 6:01 AM

OCTOBER 13 Room 311 11:15 AM

PRESENTATION Patient Age and Compliance with Contact Lens Hygiene, Lens Case Replacement and Hygiene Sheila Hickson-Curran, BSc(Hons), MCOptom, FAAO, FBCLA Robin L Chalmers, OD, FAAO

PURPOSE: To report the association between patient age and self-report of attitudes and compliance with steps in contact lens hygiene, and cleaning and replacement of lens storage cases.

METHODS: A masked internet survey of 787 soft reusable contact lens (CL) wearers was conducted in the USA that questioned respondents about their habits and practices regarding storage case hygiene practices and replacement frequency. Self-report of agreement with statements (“strongly” or “somewhat agree”) was analyzed across age groups (18-24 years, 25-29 years, 30-34 years and 35-39 years) by Fisher’s Exact Test, with p<0.05 considered significant. For replacement questions the median reported frequency is reported for each age group.

RESULTS: Respondent’s mean age was 29.3 yrs, 78% were female and 83% Caucasian. Age groups were comprised of 160 aged 18-24 years, 146 aged 25-29 years, 191 aged 30-34 years and 136 aged 35-39 years. Age was a significant factor in the report of hand washing before handling CLs (65.6% of 18-24 year olds vs 86.0% of 35-39 year olds, p)0.0001); cleaning CLs only when they irritate the eyes (37.5% of 18-24 year olds vs 20.6% of 35-39 year olds, p=0.016); being afraid that rubbing CLs will damage them (50.0% of 18-24 year olds vs. 39.7% of 35-39 year olds, p=0.019) and knowing they could do a better job of taking care of CLs (63.8% of 18-24 year olds vs 51.4% of 35-39 year olds, p=0.03). The median replacement frequency of CL storage cases was once per year for 18-24 year olds vs. once every 4-6 months for other age groups. Median frequency of CL case cleaning was once per week for 18-24 year olds and 2-3 times per week for other age groups.

CONCLUSIONS: Young CL wearers reported significant differences in their CL hygiene attitudes and behaviors and reported less frequent cleaning and replacing their CL cases. Specific, clear and repeated instructions should be tailored for the young adult contact lens wearer.

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Sheila Hickson-Curran earned her optometry qualifications from the City University, London, United Kingdom.

Sheila joined VISTAKON® in 1995 as a Research Optometrist, with positions of increasing responsibility in Research & Development. She is the co-inventor of BLINK STABILIZEDTM Technology used in ACUVUE® ADVANCE® for ASTIGMATISM and ACUVUE® OASYS® for ASTIGMATISM, for which she won a Johnson Medal, the highest award for innovation in Johnson & Johnson. In her role as Director of Medical Affairs, she provides technical education for our professional customers, as well as professional insight and counsel for Brand teams. Sheila is a Fellow of the American Academy of Optometry.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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PRESENTATION

OCTOBER 13 Room 311 11:45 AM

Patient Compliance: Is an Electronic Reminder System Effective When it Comes to Replacing Contact Lenses as Directed?

Janelle Routhier, OD, FAAO Royce Carvalho, MBA; Elizabeth Kreul-Starr, JD, MBA

PURPOSE: Patient compliance with their doctor’s recommended contact lens replacement schedule is topical, but strategies to improve compliance have not been investigated. This poster presents data on the effectiveness of an electronic reminder system for patients wearing biweekly and monthly replacement lenses.

METHODS: A targeted sample of 14,429 US contact lens wearers enrolled in an electronic reminder system were invited to participate in an online survey. Out of that target population, those who agreed to participate (n=620), answered questions regarding the use of the reminder system to help replace their contacts on time.

RESULTS: For patients who adopted the use of the reminder system, compliance with their doctors’ recommended replacement schedule increased from 40% to 77%. Ninety-five percent of the enrollees found it to be useful, while 66% believed the program changed their lens replacement behavior. Before using a reminder system, the average replacement frequency for biweekly replacement was 19.9 (±12.7) days and 35.6 (±17.6) days for monthly. After using an electronic reminder, biweekly replacement was averaged 14.7 (±3.6) days. The average for monthly replacement was 30.0 (± 6.0) days. Ninety percent agreed that the reminder system made remembering to change their lenses much easier. Reminder by email was the most popular, at 93%.

CONCLUSIONS: This survey revealed that using an electronic reminder system helped patients to change their contacts in accordance with their doctors’ recommended replacement frequency. It also reported that patients found value in having a reminder to change their lenses. In addition, patient wearing behavior was positively impacted as result of the prompts. This tool was beneficial to all replacement frequencies, increasing compliance with their doctor’s recommendation from 40% to 77%. To help keep patients on track amidst their busy lives, something as simple as an electronic reminder may be the key to compliance not only for contact lenses, but for the medical industry in general.

MONTHLY REPLACEMENT Prior to & After Use of Reminder N=533

TWO WEEK REPLACEMENT Prior to & After Use of Reminder N=533 80%

80% PRIOR AFTER

70% 60%

Prior average=19.9 Days After average=14.7 Days

50%

60%

40%

30%

30%

20%

20%

10%

10% <14 Days

14 Days

15-18 Days

19-21 Days

>21 Days

Prior average=35.6 Days After average=30.0 Days

50%

40%

0%

PRIOR AFTER

70%

0%

<30 Days

30 Days

31-45 Days

46-60 Days

17

>60 Days

Dr. Janelle Routhier earned her doctorate of Optometry from the Michigan College of Optometry at Ferris State University in 2008 and went on to complete a Cornea and Contact Lens residency at Michigan College of Optometry. She joined the VISTAKON® team in early 2011. In her role as Manager, Medical Affairs, she is responsible for providing clinical and technical insight to the company and to professional prescribers of VISTAKON® products. Previously, Dr. Routhier was contact lens clinical faculty at Michigan College of Optometry and also worked in private practice. She has developed and performed research in the area of toric orthokeratology and is also a Fellow of the American Academy of Optometry.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

40038_AbstractBook_Hi.pdf 40038 AbstractBook Hi.pdf 17

10/26/11 6:01 AM

OCTOBER 13 #7

POSTER Blur Adaptation with SimultaneousVision Contact Lenses Harold E. Bedell, PhD, FAAO Amber Gaume Giannoni, OD, FAAO; Saumil S. Patel, PhD; Katrina E. Parker, OD, FAAO; Norman E. Leach, OD, MS, FAAO; Anita Ticak, OD, MS and Ashley Wallace-Tucker, OD

PURPOSE: Subjects exposed to blurred visual stimuli are reported to undergo adaptation, such that the blurred stimuli gradually appear less blurred. We examined whether presbyopic subjects adapt to the combination of blurred and clear images that are produced by simultaneous-vision contact lens (CL) correction when worn during a trial period.

METHODS: Blur-detection and blur-acceptance thresholds were determined in 13 subjects, aged 41-56 years, before being fitted with ACUVUE® OASYS® Brand Contact Lenses for PRESBYOPIA concentric bifocal contact lenses and after a 1-2 week trial-wear period. Blur thresholds were measured at 2 m with best spherical equivalent trial-frame correction for an array of 20/40 Sloan letters that were spatially filtered to simulate the superimposed blurred and clear images produced by a two-zone lens with a central 2 mm near addition (mean = +1.6D). From trial to trial, the relative contrast of the blurred and clear components of the image was varied. Subjects reported whether each image was clear, blurred but acceptable for performing everyday visual tasks, or blurred unacceptably.

RESULTS: Before CL fitting, the mean blur-detection and blur-acceptance thresholds corresponded to relative contrasts of the blurred image (blurred-image contrast/clear-image contrast) of 0.51±0.06 (SE) and 1.80±0.61. After the trial-wear period, relative contrast thresholds were 0.52±0.04 and 1.70±0.30.

CONCLUSIONS: A 1-2 week period of wearing concentric simultaneous-vision contact lenses is not sufficient to produce a statistically significant reduction of perceived blur.

BLUR DETECTION THRESHOLDS

18

Contrast Ratio (Blurred image/Clear image)

0.6

0.4

0.2

0 Pre-trial wear

Post-trial wear

Harold E. Bedell, PhD, joined the University of Houston (UH) College of Optometry as an Assistant Professor in 1980. Previously, he received BS and MS degrees from Rensselaer Polytechnic Institute, a PhD from the University of Florida, and post-doctoral training at the University of California, Berkeley. He was named a UH John and Rebecca Moores professor in 2005. In 1999, he won the Glenn A. Fry award from the American Academy of Optometry for his research on interactions between visual perception and eye movements in persons with nystagmus. Dr. Bedell teaches courses in visual perception, eye movements and experimental methods. He received the outstanding graduate faculty teaching award at the UH College of Optometry ten times, the Cora and J. Davis Armistead faculty teaching award in 2007, and a UH teaching excellence award in 2011.

Study supported by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

40038_AbstractBook_Hi.pdf 40038 AbstractBook Hi.pdf 18

10/26/11 6:01 AM

POSTER

OCTOBER 13 #12

Colors: Iris Color Scale Based on Quantitative Color Analysis Magda Michna, PhD John Buch, OD, MS, FAAO

PURPOSE: Methods of classifying iris color available in the literature are often either based on subjective classification of iris color, or describe quantitative methodology, but do not provide a visual scale for reference. The classification of iris color is important for many reasons, including consistency in subjective iris color classification, in genetic studies, and monitoring changes of iris color with reference to ocular conditions. The purpose of this work was to use a controlled method of image capture and quantitative analysis of color to create an iris color scale.

METHODS: Many factors must be considered when creating a scientifically robust iris color scale for use in subjective assessment of iris color, from image capture to printing. Methodologies for iris image capture were rigorously evaluated and optimized to ensure accurate color representation in the digital images.

High resolution cameras and high quality optical lenses were used for image capture to ensure no artifacts were present, and camera exposure times and lighting intensities were also optimized to ensure accuracy and consistency. The color content of the resultant images was then analyzed using a methodology based on color representation schemes outlined by the Commission Internationale de l’éclairage (CIE), to ensure accurate color representation. The CIE L*a*b color space defines color based on human color perception, and is therefore the most appropriate for analysis of images that are to be used for subjective color assessment.

RESULTS: The CIE L*a*b color space was used to classify iris images not only by color, but also by lightness, allowing us to create a multi-category clinical iris color scale. The accurate production of the iris color scale on print substrates involved optimization of the color gamut using the properties of printing inks and paper reflectance.

CONCLUSIONS: We present a novel, comprehensive methodology for creating an iris color scale using sophisticated image capturing methods and scientifically rigorous color analysis. This unique methodology has potential application in other medical fields.

19

Magda Michna, PhD, came to work for VISTAKON® Division of Johnson & Johnson Vision Care, Inc. in Jacksonville, Florida, over 3 1/2 years ago and is the clinical Vision Scientist in the Research & Development division. Dr. Michna received her PhD in optical physics from the University of Melbourne, and postdoctoral training at McGill University in the field of human visual psychophysics. Dr. Michna has combined all of her previous academic research in her new role, where she is responsible for creating novel vision testing and clinical metrology, as well as conducting clinical trials.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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10/26/11 6:01 AM

OCTOBER 14 #38

POSTER How Easy Is it to Fit Soft Toric Contact Lenses to Current Non-Users?

Anna Sulley, BSc, MCOptom, FBCLA Graeme Young, OD, MPhil, PhD, FCOptom, DCLP, FAAO; Kathrine Osborn, OD, MS, FAAO, FBCLA; Chris Hunt, MSc

PURPOSE: To evaluate the ease with which non-users of toric soft contact lenses (CLs) can be fitted with toric soft lenses.

METHODS: In this one month, multi-centre study, 200 astigmats in three categories were randomly assigned to be fitted with one of two toric soft CLs featuring BLINK STABILIZEDTM Technology: etafilcon A (1-DAY ACUVUE® MOIST® Brand Contact Lenses for ASTIGMATISM) or senofilcon A (ACUVUE® OASYS® Brand Contact Lenses for ASTIGMATISM). The categories were i) spherical soft CL users, ii) lapsed CL wearers and iii) neophytes. As well as monitoring those successfully completing the study, pre-defined criteria for ‘success’ were set: acceptable fit, stable orientation, binocular VA within one line of spectacle VA, and ‘good’ to ‘excellent’ comfort and vision quality.

RESULTS: Of the 200 subjects enrolled, 99% (198) were dispensed toric CLs of whom 92% (182/198) successfully completed the 1-month study. During fitting, 88% (348/396) eyes were successfully fitted on the first attempt, and a further 12% (47/396) with two trial lenses. Based on the pre-defined criteria, the success rates were: 80%, 74% and 70% for the spherical CL wearer, CL drop-out and neophyte groups, respectively. Success was not predicted by sex, age, refractive state (myopia vs hyperopia), level of astigmatism (<1.50 vs *1.50DC), limbal hyperemia or corneal staining. For the spherical wearers, VA with toric CLs was significantly better than with habitual spherical CLs (etafilcon A: +0.06 vs +0.03 logMAR, senofilcon A: +0.09 vs +0.01 logMAR, P<0.0001). There were no significant differences in VA for the other groups.

CONCLUSION: The study has shown the relative ease with which astigmats can be successfully introduced to toric soft lenses.

HABITUAL CORRECTION STUDY LENSES (4-WEEK)

.30 .20 .10

P<0.001

.00 -.10 -.20

90

92

94

94 86

80 70 60 50 40 30 20 10

Better VA Spectacles Wearers

100

Proportion subjects (%)

20

Binocular VA (logMAR)

.40 Poorer VA

0 CL Drop Outs

Neophytes

Overall Spherical CL Lapsed Neophytes wearers wearers

Anna Sulley graduated from Aston University and spent several years in private practice before moving to Visioncare Research as a clinical investigator. She joined Hydron as International Clinical Manager in 1997 and then Johnson & Johnson Vision Care, Inc., in 2000 where she was Professional Affairs Manager until 2004. After a few years dividing her time between private practice, medical writing, clinical research and consultancy to the contact lens industry, Anna returned to Johnson & Johnson in 2009 as Clinical Affairs Manager for Europe, Middle East and Africa. Anna is Past President of the BCLA and was awarded BCLA Fellowship in 2006.

Study supported by Johnson & Johnson Vision Care, Inc.

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10/26/11 6:01 AM

POSTER

OCTOBER 14 #5

Prevalence of Sensitive Eyes in Contact Lens Wearers and the Effect of Refitting with Silicone Hydrogel Lenses Sheila Hickson-Curran, BSc(Hons), MCOptom, FAAO, FBCLA Michael Spyridon, PhD; Chris Hunt, MSc; Graeme Young, OD, MPhil, PhD, FCOptom, DCLP, FAAO

PURPOSE: A proportion of contact lens (CL) wearers report ‘sensitive eyes’ (SE). The scale and the nature of this problem, however, are unclear.

To estimate the prevalence of SE in current soft CL wearers entering clinical trials and investigate the effect of refitting SE-patients with senofilcon A silicone hydrogel CLs. METHODS: A database of 2166 current soft CL wearers aged between 18 and 45 years old, who defined as ‘normal’ as they entered the trials, was used to estimate the prevalence of ‘sensitive’ or ‘very sensitive eyes’.

Approximately half of the SE patients were refitted with senofilcon A or other soft CLs, and reassessed 2 weeks later.

RESULTS: The prevalence of SE was 12.2% in soft CL wearers. SE correlated with dryness (P<0.0001), redness (P<0.0001) and stinging (P<0.0001), with 46% of the SE-patients experiencing one or more of these symptoms. Average comfortable wearing time was significantly shorter in the SE population compared with non-SE patients (10.6 vs. 12.2 hours, P<0.001). No significant associations were found between the prevalence of SE and clinical signs (limbal or bulbar hyperemia, corneal staining). Following refitting with senofilcon A, approximately 25% of the SE-subjects experienced significant improvement in dryness (P<0.001). Limbal hyperemia (0.3 on a 0-4 scale, P<0.001), irritation (0.3 on a 0-3 scale, P=0.015) and stinging or burning (0.3 on a 0-3 scale, P=0.009) were also reduced in senofilcon A fitted SE-subjects.

CONCLUSIONS: Approximately one in eight soft CL wearers report SE and these patients are more likely to experience clinically significant symptoms. The improvement in a number of these signs and symptoms following refitting with senofilcon A lenses suggests a potentially useful option for alleviating SE.

REFITTING WITH SENOFILICON A LENSES DECREASED SIGNIFICANTLY THE FREQUENCY OF DRYNESS, STINGING OR BURNING, REDNESS AND IRRITATION (BASELINE VS. FOLLOW UP RESULTS)

60

*

*

*

*

*

*

50 All Pxs (N=2166 SEs (n=265) Non-SEs (N=1901

40

Constantly

Frequency of Symptoms

% of Pxs Qualifying for Each Criterion

PREVALENCE OF KEY SIGNS/SYMPTOMS IN THE SE POPULATION (SEs VS. NO SEs)

30 20

3

2.5 Baseline (N=63) Follow-up (N=63)

2 1.5

*

*

*

*

21

1

0.5

10 0

Never

Diagnosed Dryness

Dryness Dryness (Dry or (Freq. or Very Dry) Cons)

Redness (Freq. or Cons)

Stinging (Freq. or Cons)

SIGNS AND SYMPTOMS *P<0.001

Dryness, Redness, Stinging

0 Dryness

Sting or burn

Appear Red

Irritation

SYMPTOMS *P<0.001

Sheila Hickson-Curran earned her optometry qualifications from the City University, London, United Kingdom.

Sheila joined VISTAKON® in 1995 as a Research Optometrist, with positions of increasing responsibility in Research & Development. She is the co-inventor of BLINK STABILIZED™ Technology, used in ACUVUE® ADVANCE® for ASTIGMATISM and ACUVUE® OASYS® for ASTIGMATISM, for which she won a Johnson Medal, the highest award for innovation in Johnson & Johnson. In her role as Director of Medical Affairs, she provides technical education for our professional customers, as well as professional insight and counsel for Brand teams. Sheila is a Fellow of the American Academy of Optometry.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

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10/26/11 6:01 AM

OCTOBER 14 #24

POSTER Contact Lens Purchase Behavior: Impact of Practice Setting & Modality Giovanna E. Olivares, OD, FAAO Jordin Alford, MBA; Cristina Schnider, OD, MSc, MBA, FAAO

PURPOSE: This study examines the influence of practice setting & replacement recommendation on contact lens purchasing behavior in a large vision corrected population.

METHODS: 7500 vision corrected adults age 21-60 who had an eye exam and made a vision correction purchase (contact lens or spectacles) in the last 18 months participated in a 60-minute online survey regarding vision care practices. A subset of CL wearers were asked where they received their vision care, where they filled their prescriptions, and their recommended contact lens replacement frequency.

RESULTS: • 1125 contact lens wearers obtained a prescription from private eye care professional and 630 from a retail-affiliated eye care professional. Of these, 611 contact lens wearers used a 2-week modality lens and 727 a monthly lens • 1 in 5 patients purchase their CLs at a different location regardless of whether they are fit by a private or retail-affiliated eye care professional (P<0.05) • 1 in 5 patients—whether in monthly or 2-week replacement lenses—purchase their contact lenses at a different location regardless of whether they are fit by a private or a retail-affiliated eye care professional (P<0.05) • Only 1 in 10 patients purchased their CLs on the Internet CONCLUSIONS: Neither the location of the exam (private or retail-affiliated) or prescribed replacement frequency impact the rate at which patients “walk” with their prescriptions. Further, only 1 in 10 report purchasing their CLs on the internet. Future analysis of the data will look at factors that may influence patient decision making in the purchase of their contact lens.

22

Dr. Olivares is the Director of Professional Education at VISTAKON® Division of Johnson & Johnson Vision Care, Inc. In this role, she is responsible for the development of new and innovative educational professional programs.

Dr. Olivares graduated from the State University of New York with a doctorate degree and subsequently completed a post-doctoral fellowship program in ocular disease management in affiliation at the State University of New York College of Optometry. Upon completion of her fellowship, she became an Assistant Professor at the College of Optometry having responsibility in both didactic and clinical programs. Following her academic career, she joined Unilens Corp. USA as the Director of Professional Development and Clinical Affairs, and spent 12 years developing new presbyopic contact lenses. In 2004 she joined VISTAKON®. As the Senior Manager of Clinical Research she led a multidisciplinary group of optometrists, biostatisticians, and vision scientists that were responsible for the development of new contact lens products such as ACUVUE® ADVANCE® for ASTIGMATISM, ACUVUE® OASYS® Brand Contact Lenses for ASTIGMATISM, ACUVUE® ADVANCE® Plus, and other products that have been launched throughout the world. Dr. Olivares is a Fellow of the American Academy of Optometry.

Study sponsored by VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

40038_AbstractBook_Hi.pdf 40038 AbstractBook Hi.pdf 22

10/26/11 6:01 AM

1-DAY ACUVUE® MOIST® Brand Contact Lenses with LACREON® Technology

Because satisfied patients lead to successful practices How many of your reusable contact lens patients are experiencing dryness?

The uncomfortable truth is that many may be. Keep patients satisfied and eyes comfortable with the unsurpassed overall comfort of 1-DAY ACUVUE® MOIST® Brand1: • In a clinical study, 1-DAY ACUVUE® MOIST® wearers rated the brand superior to DAILIES®* AQUA COMFORT PLUS®* in feeling as comfortable at the end of the day as the beginning and feeling smooth on eyes all of the time1

Reference: 1. Data on file. Johnson & Johnson Vision Care, Inc. 2009.

ACUVUE® Brand Contact Lenses are indicated for vision correction. As with any contact lens, eye problems, including corneal ulcers, can develop. Some wearers may experience mild irritation, itching or discomfort. Lenses should not be prescribed if patients have any eye infection, or experience eye discomfort, excessive tearing, vision changes, redness or other eye problems. Consult the package insert for complete information. Complete information is also available from VISTAKON® Division of Johnson & Johnson Vision Care, Inc., by calling 1-800-843-2020 or by visiting jnjvisioncare.com.

1-DAY ACUVUE® MOIST®, LACREON®, INNOVATION FOR HEALTHY VISION™, and VISTAKON® are trademarks of Johnson & Johnson Vision Care, Inc. *All third-party products are trademarks of their respective companies. © Johnson & Johnson Vision Care, Inc. 2011. August 2011

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INNOVATION FOR HEALTHY VISION™

10/26/11 6:01 AM

ACUVUE® Brand Contact Lenses are indicated for vision correction. As with any contact lens, eye problems, including corneal ulcers, can develop. Some wearers may experience mild irritation, itching or discomfort. Lenses should not be prescribed if patients have any eye infection, or experience eye discomfort, excessive tearing, vision changes, redness or other eye problems. Consult the package insert for complete information. Complete information is also available from VISTAKON® Division of Johnson & Johnson Vision Care, Inc., by calling 1-800-843-2020 or by visiting jnjvisioncare.com.

ACUVUE®, 1-DAY ACUVUE® TruEye™, 1-DAY ACUVUE® MOIST®, ACUVUE® OASYS®, ACUVUE® ADVANCE®, HYDRACLEAR®, LACREON®, INNOVATION FOR HEALTHY VISION™, and VISTAKON® are trademarks of Johnson & Johnson Vision Care, Inc. © Johnson & Johnson Vision Care, Inc. 2011. August 2011

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10/26/11 6:01 AM

Because satisfied patients lead to successful practices ACUVUE速 Brand Contact Lenses are at the forefront of innovation because we constantly strive to deliver lenses that provide the kind of comfort your patients can feel and health you can see.

40038_AbstractBook_Hi.pdf 40038 AbstractBook Hi.pdf 25

10/26/11 6:01 AM

Dear Colleagues, Having grown up in Oregon, where the skies are often gray, it may seem odd that one of my professional passions involves UV protection. But what I have learned in recent years about the subject has reinforced the relevance of the topic, and the need for early and frequent education of our patients on the importance of UV protection.

Cristina M Schnider, OD, MSc, MBA, FAAO

In late 2010, a group of 13 internationally renowned authorities on the effects of UV radiation on the eye gathered in Las Vegas. This symposium was sponsored by the Eye & Contact Lens Journal and the Contact Lens Association of Ophthalmologists, and the findings were published in the July 2011 issue of Eye & Contact Lens. My key takeaway is that we need to do more to educate our colleagues on the opportunity to deliver value to our patients through providing information and options to protect their eyes from UV damage.† Here are a couple “fun facts” about UV and the eye from the July 2011 issue of Eye & Contact Lens: • Due to the unique anatomy of the eye and the earth’s orbit, the peak exposure on a late summer day for the eyes is actually around 9:00 am and 2:00-3:00 pm, versus noon when the sun is at the top of the head and eyes are actually shaded by the brow ridge. The main thing to remember is that when the sun is below an angle of about 40 degrees from the horizon, the eyes are being directly exposed • Light that enters the eye through the temporal periphery of the cornea is actually concentrated by the optics of the eye on the nasal side, offering a possible explanation for the nasal predilection of certain UV-related eye diseases such as cortical cataract • In addition to wearing shading headwear and well designed and fitted sunglasses, wearing UV-blocking contact lenses that cover the limbus provide additional protection from all sources of UV radiation incident on the cornea and limbus, whether directed, reflected or refracted† You are invited to pick up a reprint of the entire journal at our conference booth, or email us at PA@its.jnj.com. In the meantime, I hope I have whet your appetite for relating this important topic to your patients.

26 Best Regards,

Cristina M Schnider, OD, MSc, MBA, FAAO Senior Director, Medical Affairs VISTAKON® Division of Johnson & Johnson Vision Care, Inc.

References: Sasaki H, et al. UV-B exposure to the eye depending on solar altitude. Eye & Contact Lens. 2011;37(4):191-195.

Coroneo M. Ultraviolet radiation and the anterior eye. Eye & Contact Lens. 2011;37(4):214-224.

Walsh J, Bergmanson J. Does the eye benefit from wearing ultraviolet-blocking contact lenses? Eye & Contact Lens. 2011;37(4):267-272.

40038_AbstractBook_Hi.pdf 40038 AbstractBook Hi.pdf 26

10/26/11 6:01 AM

ACUVUE® OASYS® Brand Contact Lenses for ASTIGMATISM with BLINK STABILIZEDTM Technology

Because satisfied patients lead to successful practices Do your monthly astigmats experience visual blur too often?

The uncomfortable truth is they may. Satisfy your patients with the only lens designed to work solely with the blink1—2-week ACUVUE® OASYS® Brand for ASTIGMATISM with BLINK STABILIZED™ Technology. For more consistent, clear, stable vision regardless of head or eye position.

Reference: 1. Data on file. Johnson & Johnson Vision Care, Inc. 2008.

ACUVUE® Brand Contact Lenses are indicated for vision correction. As with any contact lens, eye problems, including corneal ulcers, can develop. Some wearers may experience mild irritation, itching or discomfort. Lenses should not be prescribed if patients have any eye infection, or experience eye discomfort, excessive tearing, vision changes, redness or other eye problems. Consult the package insert for complete information. Complete information is also available from VISTAKON® Division of Johnson & Johnson Vision Care, Inc., by calling 1-800-843-2020 or by visiting jnjvisioncare.com.

ACUVUE® OASYS®, BLINK STABILIZED™, HYDRACLEAR®, INNOVATION FOR HEALTHY VISION™, and VISTAKON® are trademarks of Johnson & Johnson Vision Care, Inc. © Johnson & Johnson Vision Care, Inc. 2011. August 2011

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INNOVATION INNO NOVA VATI TION ON F FOR OR H HEALTHY EALT EA LTHY HY V VISION™ ISIO IS ION N™

10/26/11 6:01 AM

ACUVUE® OASYS® Brand Contact Lenses with HYDRACLEAR® Plus Technology

Because satisfied patients lead to successful practices Are your monthly patients experiencing dryness during the 3rd or 4th week of wear?

The uncomfortable truth is they may be. Satisfy your patients with 2-week ACUVUE® OASYS® Brand: • Superior comfort across the 2-week wear cycle versus AIR OPTIX®* AQUA and Biofinity®* in 2 separate head-to-head studies1,2

References: 1. Data on file. Johnson & Johnson Vision Care, Inc. 2009. 2. Data on file.

Johnson & Johnson Vision Care, Inc. 2008.

ACUVUE® Brand Contact Lenses are indicated for vision correction. As with any contact lens, eye problems, including corneal ulcers, can develop. Some wearers may experience mild irritation, itching or discomfort. Lenses should not be prescribed if patients have any eye infection, or experience eye discomfort, excessive tearing, vision changes, redness or other eye problems. Consult the package insert for complete information. Complete information is also available from VISTAKON® Division of Johnson & Johnson Vision Care, Inc., by calling 1-800-843-2020 or by visiting jnjvisioncare.com.

ACUVUE® OASYS®, HYDRACLEAR®, INNOVATION FOR HEALTHY VISION™, and VISTAKON® are trademarks of Johnson & Johnson Vision Care, Inc. *All third-party products are trademarks of their respective companies. © Johnson & Johnson Vision Care, Inc. 2011. August 2011

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INNOVATION FOR HEALTHY VISION™

10/26/11 6:01 AM

VISTAKON®, American Optometric Foundation Fellowship and Grant Recipients VISTAKON® is proud to have partnered with the American Optometric Foundation for over a decade, providing over one million dollars of support for scholarships, fellowships, and research grants.

The recipients of the 2011 VISTAKON® Ezell Fellowships are:

The recipients of the 2011 AOF VISTAKON® Award of Excellence are:

Tatiana Ecoiffier, MEng, MS University of California Berkeley School of Optometry

Joseph Conrad

The Ohio State University

Brittany Nelson

Pacific University College of Optometry

Katherine Paulsen

Southern College of Optometry

Kristina Haworth, BBA, OD, MS, FAAO University of Houston College of Optometry

Katie Wicks

University of Houston

Veronica Woi

Southern California College of Optometry

Each will receive $8,000 toward their graduate education and $3,000 travel grants to the annual meetings of the American Academy of Optometry and the Association for Research in Vision and Ophthalmology.

VISTAKON® Ezell Fellows 2005-2010 2005 Danielle Robertson

University of Houston

2005 Ling Chi Huang

University of Houston

2006 Jose Capo-Aponte

State University of New York

2006 Johannes Burge

University of California, Berkeley

Lindsey Barouh

Pennsylvania College of Optometry

Yin-Yin Aung

New England College of Optometry

Sheila Morris

University of Alabama at Birmingham

Brian Paul, OD

Nova Southeastern University

Dana Pollack

State University of New York

Tanya Polonenko

University of Waterloo

Stefanie Ratermann

Illinois College of Optometry

Pam Satjawatcharaphong

University of California, Berkeley

Richard Wardé

University of Montreal

Derek Wiles

University of Missouri, St. Louis

Lauren Quaine

Michigan College of Optometry

Colby Fletcher, OD

Indiana University

Charlie C. Dao, OD

Puerto Rico School of Optometry

Natalie Pham, OD

Northeastern State University Oklahoma College of Optometry

2007 Zan Pan

State University of New York

2007 Rachel Redfern

University of Houston

Lindsay Sicks, OD

Norfolk State University

University of Houston

Chris Kenrick, OD

New England College of Optometry

2008 Lakshman Subbaraman

University of Waterloo

2011 Sheldon Wechsler Contact Lens Residency Awards

2009 Eric Ritchey

The Ohio State University

2008 Joe Phillips

2011 George W. Mertz Contact Lens Residency Award

Steven J. Warne, OD

University of Alabama at Birmingham

2009 Vidhyapriya Sreenivasan University of Waterloo

Michael Rebarchik, OD

New England College of Optometry

2010

Nicole Putnam, MS

University of California, Berkeley

2011 Terrance Ingraham Pediatric Optometry Residency Awards

2010

Johanna TuklerHenriksson, BS

University of Houston

Jenelle L. Mallios, OD

New England College of Optometry

Yos M. Priestley, OD

New England College of Optometry

VISTAKON® Research Grant Recipients 2005-2010 2005

$25,000

Joseph A. Bonanno Indiana University Tear Oxygen Tension beneath Silicone Hydrogel Contact Lenses

2005

$10,000

Barbara A. Fink The Ohio State University Contributions of Silicone Hydrogel Lens Thickness, Lens Permeability, and Tear Exchange to Corneal Oxygen Supply

2006

$25,000

Alison McDermott University of Houston Antimicrobial Contact Lenses

2006

$10,000

Lyndon Jones University of Waterloo School of Optometry A Novel Method to Quantify Protein Adsorption and Absorption on Hydrogel Contact Lenses Using Confocal Microscopy

2007

$25,000

Nancy Keir University of Waterloo School of Optometry Investigation of the Optical Performance of Silicone Hydrogel Contact Lenses

2007

$10,000

Ewen King-Smith The Ohio State University The Relation of Pre-Lens Tear Film Thinning to the Thickness and Distribution of the Lipid Layer

2008

$25,000

Danielle M. Robertson University of Texas Southwestern Medical School The Role of the Post Lens Tear Film in Lipid Raft-mediated Pseudomonas Internalization

2008

$25,000

H. Dwight Cavanagh University of Texas Southwestern Medical School The Role of the Post Lens Tear Film in Lipid Raft-mediated Pseudomonas Internalization

2008

$10,000

Lyndon Jones University of Waterloo School of Optometry The Impact of Rub & No-Rub Care Products on Protein Removal and Localization

2008

$10,000

Doerte Luensmann University of Waterloo School of Optometry The Impact of Rub & No-Rub Care Products on Protein Removal and Localization

2009

$25,000

Frank Anasrasopoulos/Carol Lakkis Victorian College of Optometry The Effect of Contact Lens Materials on Expression of Pseudomonas Aeruginosa Virulence Factors

2009

$10,000

Blanka Golebiowski/Isabelle Jalbert University of New South Wales Nerves and Neuropeptides in Contact Lens Related Dry Eye

2010

$25,000

Loretta Szczotka-Flynn, OD, PhD/IIene Gipson, PhD Harvard Medical School Uncovering the Role of Mucins in Contact Lens Induced Corneal Infiltrates

2010

$10,000

Alex Hul, OD/David McCanna, BSc, MA, PhD University of Waterloo School of Optometry Engineering of Novel Contact Lens Materials for Ciprofloxacin

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For further information, contact: Tracy Kitts Foundation Coordinator American Optometric Foundation (301) 984-4734 tracyk@aaoptom.org

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FA C T :

Th #1 reason patients overwear The their contact lenses is forgetfulness1

THE ACUMINDER™ TOOL

THE ONLY CONTACT LENS REMINDER TOOL PROVEN TO INCREASE PATIENT COMPLIANCE

ACUMINDER™ makes patient compliance easier.

In a recent survey of reusable lens wearers…

WITHOUT ACUMINDER™:

42% of patients were compliant with their

wear schedule2

WITH ACUMINDER™:

30

77% of patients were compliant with their

wear schedule2

Help patients stay on schedule and in your practice—patients join free at ACUMINDER.COM References: 1. Dumbleton K, Woods C, Jones L, Fonn D, Sarwer DB. Eye & Contact Lens. 2009;35:164-171. 2. Data on file. Johnson & Johnson Vision Care, Inc. 2010.

ACUMINDER™ is a trademark of Johnson & Johnson Vision Care, Inc. © Johnson & Johnson Vision Care, Inc. 2011. "VHVTU 2011

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OUR CREDO We believe our first responsibility is to the doctors, nurses and patients, to mothers and fathers and all others who use our products and services.

In meeting their needs everything we do must be of high quality.

We must constantly strive to reduce our costs in order to maintain reasonable prices. Customers’ orders must be serviced promptly and accurately.

Our suppliers and distributors must have an opportunity to make a fair profit.

We are responsible to our employees, the men and women who work with us throughout the world. Everyone must be considered as an individual.

We must respect their dignity and recognize their merit. They must have a sense of security in their jobs. Compensation must be fair and adequate, and working conditions clean, orderly and safe. We must be mindful of ways to help our employees fulfill their family responsibilities. Employees must feel free to make suggestions and complaints. There must be equal opportunity for employment, development and advancement for those qualified. We must provide competent management, and their actions must be just and ethical.

We are responsible to the communities in which we live and work and to the world community as well. We must be good citizens — support good works and charities and bear our fair share of taxes. We must encourage civic improvements and better health and education. We must maintain in good order the property we are privileged to use, protecting the environment and natural resources.

Our final responsibility is to our stockholders. Business must make a sound profit.

We must experiment with new ideas. Research must be carried on, innovative programs developed and mistakes paid for. New equipment must be purchased, new facilities provided and new products launched. Reserves must be created to provide for adverse times. When we operate according to these principles, the stockholders should realize a fair return.

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ACUVUE® Brand Contact Lenses are indicated for vision correction. As with any contact lens, eye problems, including corneal ulcers, can develop. Some wearers may experience mild irritation, itching or discomfort. Lenses should not be prescribed if patients have any eye infection, or experience eye discomfort, excessive tearing, vision changes, redness or other eye problems. Consult the package insert for complete information. Complete information is also available from VISTAKON® Division of Johnson & Johnson Vision Care, Inc., by calling 1-800-843-2020 or by visiting jnjvisioncare.com. †

Helps protect against transmission of harmful UV radiation to the cornea and into the eye.

WARNING: UV-absorbing contact lenses are NOT substitutes for protective UV-absorbing eyewear such as UV-absorbing goggles or sunglasses because they do not completely cover the eye and surrounding area. You should continue to use UV-absorbing eyewear as directed. NOTE: Long-term exposure to UV radiation is one of the risk factors associated with cataracts. Exposure is based on a number of factors such as environmental conditions (altitude, geography, cloud cover) and personal factors (extent and nature of outdoor activities). UV-blocking contact lenses help provide protection against harmful UV radiation. However, clinical studies have not been done to demonstrate that wearing UV-blocking contact lenses reduces the risk of developing cataracts or other eye disorders. Consult your eye care practitioner for more information.

ACUVUE® ADVANCE® Brand Contact Lenses for ASTIGMATISM block greater than 90% of UV-A rays and 99% of UV-B rays.

ACUVUE® OASYS® Brand Contact Lenses for ASTIGMATISM block greater than 90% of UV-A rays and 99% of UV-B rays.

ACUVUE® Brand Contact Lenses block greater than 82% of UV-A rays and 97% of UV-B rays.

ACUVUE®, 1-DAY ACUVUE® MOIST®, ACUVUE® ADVANCE®, ACUVUE® OASYS®, 1-DAY ACUVUE® TruEyeTM, HYDRACLEAR®, ULTRA-CLEAN™, BLINK STABILIZED™, LACREON®, ACUMINDER™, CLUE: Contact Lens User ExperienceTM, PUPIL INTELLIGENT DESIGN™, STEREO PRECISION TECHNOLOGY™, INNOVATION FOR HEALTHY VISIONTM, and VISTAKON® are trademarks of Johnson & Johnson Vision Care, Inc. ODLeanTM and THE VISION CARE INSTITUTETM are trademarks of THE VISION CARE INSTITUTETM, LLC. *All third-party trademarks are owned by their respective companies. © Johnson & Johnson Vision Care, Inc. 2011. August 2011.

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