o ur 4 1 ST ye ar
RIBBON CUTTING
ON TH E BIG S TAGE
Covering Homewood, East Baltimore, Peabody,
Students share their dreams
Peabody Opera Theatre
SAIS, APL and other campuses throughout the
for the future East Baltimore
performs ‘The Rake’s Progress’
Baltimore-Washington area and abroad, since 1971.
Community School, page 7
at The Lyric, page 6
November 14, 2011 P U B L I C
The newspaper of The Johns Hopkins University
H E A L T H
Addressing childhood obesity
Volume 41 No. 12
O U T R E A C H
Navigating the minefield of inner-city adolescence
By Tim Parsons
Bloomberg School of Public Health
Continued on page 4
2
will kirk / homewoodphoto.jhu.edu
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he Johns Hopkins Bloomberg School of Public Health has been awarded a $16 million U54 cooperative agreement from the National Institutes of Health to establish a global center of excellence to address the childhood obesity Global effort epidemic. The Johns Hopkins Global Center will include for Childhood Obeinvestigators sity will emphasize the integration of geospatial analysis from five with a systems science and transdisJHU schools ciplinary approach to childhood obesity, bringing together basic science, epidemiology, nutrition, medicine, engineering and environmental and social policy research, among other fields, in an unprecedented, innovative way. Based at the Johns Hopkins Bloomberg School of Public Health, and in collaboration with scientists at the NIH, the center will involve more than 40 investigators from 15 domestic and international institutions, including faculty from five Johns Hopkins schools: the Whiting School of Engineering, the schools of Medicine, Nursing and Public Health, and the Krieger School of Arts and Sciences. The $16 million grant, provided by the NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development and the NIH Office of Behavioral and Social Sciences Research, will fund research and training initiatives over the next five years. The Johns Hopkins University and several other institutions are providing an additional $4 million in funding support. The Global Center for Childhood Obesity is a key new initiative under the auspices of the National Collaborative on Childhood Obesity Research, which coordinates childhood obesity research
Jennifer Fishkin of SAIS and Laura Castelli of American University at Eliot-Hine Middle School, home this year for PeaceKidZ, a for-credit SAIS course founded by I. William Zartman, a renowned expert in conflict resolution and negotiation.
SAIS students offer D.C. kids school-based conflict resolution By Greg Rienzi
The Gazette
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ulia Romano called it “the camp game.” The 10 teenage students at SunRise Academy day school in Washington, D.C., were asked to break up into two groups and negotiate joint use of a co-owned campground, replete with swimming hole, picnic area, cabins and open spaces. Do they cut the camp in half? Share use
of the areas? Who gets to use it on the weekends? Who sleeps where? Romano had played the same game in a conflict management class at SAIS, and the marathon session had lasted nearly seven hours. The SunRise Academy students came Continued on page 5
C O L L A B O R A T I O N
Carey School and MICA partner for innovative degree New MBA/MA in Design Leadership is the first program of its kind
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he Johns Hopkins Carey Business School and the Maryland Institute College of Art will partner to launch the MBA/MA in Design Leadership, focusing on the integration of creative thinking into all aspects of organizational management and development. In addition to providing the knowledge and skills traditionally associated with an MBA curriculum, this full-time, dual-degree program will seek to prepare graduates to
In Brief
Lieber Institute for Brain Development opens; 30 years of ‘36-Hour Day’; Adopt-a-Family
12
assume roles as transformative leaders. The program, which is in development for 2012, is the only one in the country in which students can simultaneously earn graduate degrees from both a business school at a major research university and a major college of art and design. “This dual-degree program presents an exciting and novel opportunity to develop a new generation of design leaders with the knowledge, skills and talents that will enable them to have impact across multiple disciplines and domains,” said William W. Agresti, professor and associate dean for professional programs at the Carey Business School. “It will build the management and inno-
vation capacity of designers, engineers and budding entrepreneurs while instilling the confidence that comes from a solid understanding of the core business disciplines,” Agresti said. “It’s difficult to imagine a timelier program, given the tremendous need for innovation, collaboration and leadership for advancing organizations and society.” “The new MBA/MA in Design Leadership draws upon the complementary strengths of two great institutions and builds upon their history of successful collaboration,” said Ray Allen, MICA’s vice president for academic affairs and provost. “Through an active and
C A L E N D AR
Karl Rove at MSE Symposium; Eid AlAdha banquet; ‘Introduction to Facebook’
Continued on page 9
10 Job Opportunities 10 Notices 11 Classifieds
2 2011 2 THE THE GAZETTE GAZETTE •• November August 15, 14, 2011
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Gala marks opening of Lieber Institute for Brain Development
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riends and families of people with mental illness, mental health advocates, philanthropists and members of the pharmaceutical and biotechnology industries joined Johns Hopkins University officials and research scientists last week to celebrate the opening of the Lieber Institute for Brain Development. The event was held Thursday night in the university’s George Peabody Library. Within the next five years, the Lieber Institute, based in the new science and technology park adjacent to the Johns Hopkins medical campus in East Baltimore, plans to recruit 100 scientists, many of whom will have appointments at the Johns Hopkins School of Medicine. All will conduct medical research into the origins of mental illness, especially schizophrenia, a disorder for which there have been few new treatments in the last half-century. More than 4 million Americans suffer from developmental brain disorders. Among the attendees at the celebration were New York philanthropists Stephen Lieber; his wife, Connie; and their son and daughter-in-law. The Lieber family committed $100 million to establish the institute. An additional $20 million was donated by the Maltz Family Foundation in Cleveland to fund what it describes as “a Manhattan project” to tackle neurodevelopmental health issues. Among the reasons the donors cited for locating the Lieber Institute next to Johns Hopkins is the university’s reputation in brain sciences research and its proximity to the National Institutes of Health. Johns Hopkins President Ronald J. Daniels, a member of the Lieber Institute’s board of directors, offered opening remarks. Other speakers included Lieber Institute CEO Daniel R. Weinberger, Rep. Sue Myrick of North Carolina and Lieber.
JHU Press marks 30 years of ’36-Hour Day’ with 5th edition
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hen the Johns Hopkins University Press published The 36-Hour Day in 1981, the subject of the book—Alzheimer’s disease and related dementias—was little known and barely discussed. In the 30 years since, 2.5 million copies of the Nancy Mace and Peter Rabins– authored book have been sold, and the fifth edition—with 30,000 trade paper and 5,000 large-print copies—is now available. It is also very popular among owners of e-readers. “That The 36-Hour Day is as popular an e-book as it has been in print editions is testament to its enduring value to caregivers,” said Kathleen Keane, director of the JHU Press. The book was born of mimeographed
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pamphlets that Mace and Rabins, both then of the T. Rowe and Eleanor Price Teaching Service at the Department of Psychiatry and Behavioral Sciences at the Johns Hopkins School of Medicine, had created to assist caregivers of those with memory-related disorders. Today, it is considered the “bible” in its field.
Cafe becomes first ‘zero waste’ dining facility at Homewood
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zafran Cafe in the Space Telescope Science Institute has reached a milestone: It’s the first “zero-waste” dining facility on the university’s Homewood campus. Everything used in the cafe is washable, reusable, recyclable or compostable. “Thanks to our partnership with the institute and Johns Hopkins University, our organic waste and our biodegradable to-go containers are now being picked up three times a week. Very little is going to a landfill,” said Irena Stein, Azafran’s chef/owner. Plastic bottles have been scratched from the menu. Customers are encouraged to use the dining room’s water filter to replenish their own reusable bottles, and the only juices sold are the Odwalla brand, whose containers are made of plant-based material. Even the lighting has been changed, with 150 watt bulbs being replaced by 23 watt ones.
Needy families and seniors can be ‘adopted’ for holidays
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he Office of Work, Life and Engagement is partnering with local nonprofit and social service agencies to provide gifts, clothing and/or grocery gift certificates to families, children and seniors who are facing hardships and are in need of assistance during the holiday season. All Johns Hopkins faculty, staff, students and retirees are invited to help brighten their holidays. Individuals and groups interested in adopting a family or senior should complete the registration form at hopkinsworklife.org/ community/adopt_fam_form.html no later than Friday, Dec. 9. For more information on the Adopt-aFamily/Adopt-a-Senior Program, go to www .hopkinsworklife.org/community/adopt_ family.html. For questions, email bmonroe6@jhu.edu or call 443-997-0338.
Next issue of ‘Gazette’ to be published Nov. 28
D
ue to the Thanksgiving holiday, The Gazette will not be published the week of Nov. 21. The deadline for calendar and classifieds submissions for the Nov. 28 issue is noon on Tuesday, Nov. 15.
Contributing Writers Applied Physics Laboratory Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg, Patrick Ercolano Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort
The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Communications and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date. Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 410343-3362 or gazellegrp@comcast.net.
November 14, 2011 • THE GAZETTE
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It’s an A-plus for student in Homewood Security’s ‘classroom’ By Dennis O’Shea
University Administration
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hristina Warner tagged along on one of the university’s weekly neighborhood security walks, which teach students how to combat crime. Apparently, she’s a fast learner. Before the hour-and-a-quarter stroll through Charles Village was over, the senior had triggered a police manhunt and was responsible for the arrest of a wanted criminal. “It’s pretty unbelievable,” the Writing Seminars major said last Wednesday, the morning after she spotted a burglar on a rooftop and alerted the walk’s leaders. Warner, coincidentally a student employee in Campus Safety and Security’s lost and found department and also a co–editor in chief of the Johns Hopkins News-Letter, arranged for fellow Pi Beta Phi sorority members to join the Nov. 8 neighborhood tour and safety information session.
It was just after 8 p.m., about 35 minutes into the walk, when the group of security officers and about 10 students marched into an alley behind the 3000 block of Guilford Avenue, Warner said. The 21-year-old from Tampa, Fla., had actually been on a walk before, about six months ago, and remembered hearing then that it’s a good idea to keep an eye open for burglars on rooftops. “So as we came around the corner, I looked up and saw someone up there,” Warner said. She assumed at first it was a homeowner or resident. “But then,” she said, “I saw the person crouch down. And I realized there were no lights on up there.” Ed Skrodzki, executive director of Homewood Campus Safety and Security, had just informed the group that there had been recent second- and third-floor break-ins in the area, so Warner told Lt. Bruce Miller, Security’s training officer, what she had seen. Miller looked up and could see the man
as well; he alerted an off-duty police officer who was along on the walk. The officer called for backup, and at least three patrol cars were on the scene very quickly, Skrodzki said. The officers went up to the roof, found and identified the man and arrested him. By then, Warner said, “we were about a block away and there was a helicopter flying overhead. I thought they were kidding when they told me it was there because of what I saw.” Soon, however, she learned that the man had been caught—and that he was wanted for a late-September burglary at the residence of some Johns Hopkins students. He had also been arrested in August for an attempted break-in at another student residence nearby. Baltimore police said that the arrest spotlighted a close working relationship with Johns Hopkins. “I think people would be hard-pressed to find any two organizations that have a stronger or more collaborative partnership than the Baltimore Police Department and
Johns Hopkins,” police spokesman Anthony J. Guglielmi said. “In addition to our shared camera technology, the Police Department is practically embedded with personnel from both the university and the hospital system, so whenever a public safety situation arises, it is handled timely and seamlessly.” Skrodzki said that Security has taken students on community safety walks since 2008. Sometimes, he said, neighborhood residents also walk along. A large group of students and officers walking the streets deters crime, he said, and the program teaches students about living more safely in an urban environment. “The street is our classroom,” he said. “We point out unlocked windows in homes and concealed areas where people can hide. We talk about what to do if you see a suspicious person coming toward you.” And if the street is Security’s classroom, Skrodzki said, Warner has earned an A-plus. “She’s doing an excellent job,” he said. “She’s an excellent student.”
Nonemergency angioplasty OK at hospitals without cardiac surgery B y E l l e n B e t h L e v i tt
Johns Hopkins Medicine
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ospitals that do not have cardiac surgery capability can perform nonemergency angioplasty and stent implantation as safely as hospitals that do offer cardiac surgery. That is the finding of the nation’s first large randomized study to assess whether patients do just as well having nonemergency angioplasty performed at smaller community hospitals that do not offer cardiac surgery. Results of the Cardiovascular Patient Outcomes Research Team Elective Angioplasty Study were presented Nov. 14 at the American Heart Association’s Scientific Sessions 2011 in Orlando, Fla. The study, led by Johns Hopkins cardiologist Thomas Aversano, evaluated the outcomes of more than 18,500 patients who were randomly assigned to have heart artery–opening angioplasty or stenting at hospitals with or without cardiac surgery capability. The study included 60 hospitals in nine states without cardiac surgery backup. In order to participate in the study, those hospitals had to perform a minimum of 200 angioplasty procedures each year and complete a formal angioplasty development program.
Emergency angioplasty is performed during a heart attack, when a vessel needs to be opened right away to restore blood flow in the heart. Nonemergency procedures are offered to patients with blockages that may be causing chest pain. “Historically, angioplasty has been performed at hospitals that had cardiac surgery backup in case complications from the procedure required emergency surgical intervention. Initially, in the late 1970s, the rate of complications requiring emergency surgery was as high as 15 percent,” said Aversano, who is an associate professor of medicine at the Johns Hopkins University School of Medicine. “Today, however, the rate of complications from angioplasty is very low.” During angioplasty, a tiny balloon is inflated within a coronary artery to push away plaque that is causing a blockage in the vessel. Stents, which act like tiny scaffolds, also can be put in place to keep the artery open. In rare cases, the procedure can cause a tear in the vessel or closing of the artery, requiring open-heart surgery to repair the problem. Data from the study indicated that emergency surgery was rarely needed, and patients in neither group were more likely to have such a complication. Also, the researchers found that the death rate within six weeks for any cause was less than 1 percent among
patients in both groups. The American Heart Association and the American College of Cardiologists currently recommend that nonemergency angioplasty be performed only in hospitals that offer open-heart surgery. “Hospitals with cardiac surgery usually have a higher volume of heart-related cases overall, and that’s one reason why those hospitals have been thought to offer better quality of care for nonemergency procedures,” said Aversano, who added that until this study, there was a lack of good outcomes data. The researchers said they do not believe that every hospital should be performing angioplasty. They wanted to know, however, whether hospitals that offer emergency angioplasty to open blocked coronary arteries in heart attack patients can also safely perform elective angioplasty. “It is not reasonable to have doctors, nurses and technicians who are specially trained in performing angioplasty on hand 24/7 just to handle emergency cases,” Aversano said. “Also, having the ability to perform elective cases, as well as emergency ones, increases quality that comes with more experience.”
About 850,000 angioplasties are performed in the United States each year. Many states restrict hospitals that don’t offer cardiac surgery from performing angioplasty, which is a minimally invasive procedure performed by specially trained cardiologists rather than cardiac surgeons. As a result, hospitals feel pressured to create costly cardiac surgery programs so that they can offer angioplasty. “The goal of our study,” Aversano said, “is to give health care planners the best possible information on which to base their decisions about the allocation of resources so that patients can have access to the highest quality of care.” More data from the study, focusing on the quality of procedures, are expected to be released in early 2012. Those data will reveal patient outcomes nine months after their angioplasty in terms of death and heart attack, and whether the vessel that was opened by angioplasty or stenting became blocked again, requiring another procedure. The study centers, which include Johns Hopkins, Duke University and the Maryland Medical Research Institute, are funded by the hospitals participating in the study.
A P P O I N T M E N T
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homas Smith has been named director of palliative care for Johns Hopkins Medicine and the inaugural Harry J. Duffey Family Professor of Palliative Care in the School of Medicine’s Department of Oncology. In this new directorship, he will lead palliative care efforts throughout the system. “Tom has a national and international reputation as one of the foremost leaders in the field of palliative care,” said Edward D. Miller, the Frances Watt Baker, M.D., and Lenox D. Baker Jr., M.D., Dean of the Medical Faculty and CEO of Johns Hopkins Medicine, in making the announcement. Noting that Smith is board certified in oncology and pain/palliative medicine, he said that his research focuses on neuropathic pain, care at the end of life and bending the cost curve in patients with life-limiting conditions. “An accomplished teacher and researcher, as well as a breast cancer clinician, Tom also serves as a spokesperson for the Center to Advance Palliative Care and the American Society of Clinical Oncology,” he added.
Before joining Johns Hopkins, Smith served as co-director of the Massey Cancer Center Cancer Control and Prevention Program at the Virginia Commonwealth University Massey Cancer Center. He also held the positions of Endowed Professor of Palliative Care Research and the Esteemed Professor of Medicine for Oncology. After receiving his bachelor of science degree summa cum laude from the University of Akron and his medical degree cum laude from Yale University School of Medicine, Smith did his residency in internal medicine at the University of Pennsylvania. He then completed a fellowship in hematology and oncology at Virginia Commonwealth University and a special fellowship in medical oncology at the National Cancer Institute. “Tom’s broad range of expertise in systems issues related to patients across the medical spectrum in need of palliative care, and his outstanding research and clinical care in the oncology setting, will set apart our institution’s palliative care program,” Miller said.
DAVID CHISHAM
Thomas Smith named director of palliative care for JHM
Lara Mittereder, a Johns Hopkins biotechnology graduate student, conducts an experiment on the Montgomery County Campus with seventh-graders Jamie Winberg, Hannah Pearlstein and Maddy Zarchin.
Frontiers in Medicine and Science Day
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he Johns Hopkins Montgomery County Campus recently hosted 600 seventh-graders for the third annual Frontiers in Science and Medicine Day. The event, which is run in partnership with 17 other research centers, companies and health care organizations, includes an hour of hands-on science and medical activities
at the campus and an hourlong lab tour at one of 10 different locations in Montgomery County’s Shady Grove Life Sciences Center. The day is coordinated by staff from Johns Hopkins’ Office of the Provost and Center for Biotechnology Education, which is part of the Krieger School of Arts and Sciences’ Advanced Academic Programs. —Robin Ferrier
4 2011 4 THE THE GAZETTE GAZETTE •• November August 15, 14, 2011
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Soldiers evacuated with headaches don’t return Headaches keep soldiers from returning to active duty in Iraq, Afghanistan By Stephanie Desmon
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eadaches, a virtually universal human complaint at one time or another, are among the top reasons for medical evacuation of military personnel from Iraq and Afghanistan, and for ongoing depletion of active-duty ranks in those countries, according to research led by Johns Hopkins specialists. Just one-third of soldiers sent home because of headaches return to duty in either place, the research shows. “Everyone gets headaches, and there are generally physical or psychological stressors that contribute to them,” said study leader Steven P. Cohen, an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine and a colonel in the U.S. Army Reserve. “War amplifies all stressors, which may be why headaches take such a great toll in soldiers overseas.” The findings, published online in Cephalalgia, the journal of the International Headache Society, highlight one of the fastestgrowing causes of medical evacuations from the two prolonged military conflicts. They
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are a significant and worrisome contributor to the depletion of military units overseas, Cohen said. Overall, neurological illness is one of the top three causes of noncombat-related loss of unit strength in Operations Iraqi Freedom and Enduring Freedom, and headaches are the most common neurological complaint in the war zones. Cohen and his team found that post-concussion headaches and migraines were the most common forms of headache requiring evacuation. Physical trauma led to almost half the debilitating headaches, they determined. Cohen said that a significant number of headaches were the result of damage to or pressure on the occipital nerve, located in the back of the head, which is often caused by the heavy Kevlar helmets soldiers are required to wear on patrol and for long periods. “Everyone who goes on patrol wears a Kevlar helmet,” Cohen said. “[The helmets] are heavy. They are hard to wear. But if you get a headache from your helmet, you still must wear it. If you can’t tolerate your helmet, you can’t do your job. It would be too dangerous. So these folks end up being evacuated and not returning to duty.” The study results emerged when Cohen and his colleagues reviewed the medical records of all 985 military personnel— roughly one in 1,000 soldiers deployed in the regions—medically evacuated from Iraq and Afghanistan between 2004 and 2009 with a primary diagnosis of headache. Not included in the study were those who were evacuated primarily for other reasons (trauma, for example) who suffered headaches as a consequence. Some 67 percent never returned to the war zone, the researchers found. Those most likely to return were officers, whose jobs are often less physically taxing, and women, who rarely have combat roles. Only one in five of those whose headaches were associated with physical trauma, such as post-concussion headaches, returned to duty, while nearly half of those who were evacuated with tension headaches went back to the war zone. For those headache sufferers who also had a diagnosis of a psychiatric illness or traumatic brain injury, the return to duty rate
was among the lowest. Those whose headaches were treated with narcotic painkillers were also far less likely to return to work in a war zone. Although headaches can be difficult to diagnose—there is no real independent test to validate headache pain beyond the victim’s assessment of pain—Cohen said he doesn’t believe that soldiers are exaggerating symptoms in hopes they will be sent home from war. “Headaches can really be tough to manage,” said Cohen, who is also director of chronic pain research at Walter Reed National Military Medical Center. “When people have bad headaches, they often can’t think or work. They’re incapacitated. That doesn’t work in a war zone.” Cohen said that his data can’t quantify how prevalent headaches are among deployed personnel, only how many who report them are medically evacuated. It is important, he said, that military doctors understand how headaches affect those on the ground and make efforts to treat them more successfully where they are, rather than turn to evacuation. He said that better guidelines for the management of headaches, both on the ground and postevacuation, could help retain soldiers on active duty in war zones. Also, he said, better design of helmets could reduce strain on the occipital nerve and prevent at least one common type of headache. The study was funded by the John P. Murtha Neuroscience and Pain Institute, the U.S. Army and the Army Regional Anesthesia and Pain Medicine Initiative. Other Johns Hopkins researchers involved with the study were Artemus Flagg II and Sam M. Galvagno Jr.
Obesity
training infrastructure for building the capacity for integrating systems science into obesity and chronic disease research. Study results are expected to inform policy design and future empirical research. Michael J. Klag, dean of the Bloomberg School of Public Health, said, “Childhood obesity is a pressing issue in both the United States and developing countries. The Global Center for Childhood Obesity will seek answers to this challenge, which is in line with the Bloomberg School’s fundamental mission of protecting health and saving lives, millions at a time.” Added Lloyd Minor, provost and senior vice president for academic affairs at Johns Hopkins, “The Global Center for Childhood Obesity will draw upon resources from across Johns Hopkins University to focus our diverse scientific and academic resources on addressing the obesity epidemic in new ways.” According to the World Health Organization, worldwide obesity has more than doubled since 1980. In 2008, 1.5 billion adults ages 20 and older were overweight or obese, and 65 percent of the world’s population lives in countries where overweight and obesity kill more people than underweight. Nearly 43 million children under age 5 were overweight in 2010. According to the CDC, childhood obesity in the United States has more than tripled in the last 30 years. In 2008, more than onethird of American children and adolescents were overweight or obese, a condition that greatly increases the risk of obesity-related illnesses, such as type 2 diabetes, hypertension and heart disease. Prevention of obesity in children is a key to fighting the global epidemic. G
Continued from page 1 across the NIH, the Centers for Disease Control and Prevention, the Robert Wood Johnson Foundation and the U.S. Department of Agriculture. In addition to studying the drivers of the childhood obesity epidemic and environmental and policy interventions, the center will provide rapidresponse grants to investigators in the field worldwide to obtain time-sensitive data on environmental and policy changes relevant to childhood obesity. “The new center will address many needs in the prevention and study of childhood obesity. This initiative will help create research and training opportunities that go beyond traditional methods, and on an unprecedented global scale,” said Youfa Wang, founding director of the center and an associate professor in the Bloomberg School’s Department of International Health. Layla Esposito, program director from the National Institute of Child Health and Human Development, said, “The center’s focus on systems science will help train a new generation of researchers and public health professionals to help fight the growing global epidemic of childhood obesity and noncommunicable chronic diseases. We are going to bring together a large number of investigators from many different disciplines and from different countries to address the complexity of childhood obesity.” The center will provide a research and
Related websites Steven Cohen:
www.hopkinsmedicine.org/pain/ blaustein_pain_center/physicians/ cohen.html The study online:
cep.sagepub.com/content/early/ recent
November 14, 2011 • THE GAZETTE
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Finding: Healthy people over 70 can safely donate a kidney
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idney transplants performed using organs from live donors over the age of 70 are safe for the donors and lifesaving for the recipients, new Johns Hopkins research suggests. The study shines new light on a long-ignored potential source of organs that could address a profound national shortage. Although the study found that kidneys from older donors were more likely to fail within 10 years of transplant when compared with kidneys from donors ages 50 to 59 (33.3 percent failure rate vs. 21.6 percent), patients who received older donated kidneys were no more likely to die within a decade of transplantation than those whose kidney donors were between 50 and 59. “A lot of people come up to me and say, ‘I wish I could donate a kidney, but I’m too old,’ ” said Dorry Segev, an associate professor of surgery at the Johns Hop-
Conflict Continued from page 1 to an arrangement within a half-hour. The discussion got heated at times, but all in good fun. Romano said that the students, most of whom had academic or disciplinary issues, could put the game in perspective. “These students negotiate difficult circumstances each day, even what city blocks to safely walk down on the way to school,” Romano said. “Many of these kids don’t have easy lives.” Romano was at SunRise Academy as part of PeaceKidZ, an after-school program founded in 2002 by I. William Zartman, a renowned expert in conflict resolution and negotiation who for decades directed the Conflict Management and African Studies programs at SAIS. Zartman, now a professor emeritus, says that he wanted students in the school’s Conflict Management program to apply some of the knowledge and principles they were learning on an international scale in class to the conflicts faced daily by kids, including schoolyard fights, peer pressure, disagreements with parents and anger-management issues. “I never thought we could go in and change their behavior and make them all become angels, but perhaps we could just make them more aware of what is going on around them,” Zartman said. “Is there a conflict corner in your school? Why? What happens there, and can it be avoided?” The SAIS program, a for-credit course offered in both the spring and fall semesters, is designed to introduce conflict resolution to students ages 12 to 18 in both relevant and fun ways. Most of the children who participate are selected because they face disciplinary issues, have been suspended for various reasons or are just more prone to getting into conflict situations. The PeaceKidZ (the Z is a nod to Zartman) counselors role play, play games and use videos to elicit responses from the students. They work in groups of two and three and meet with the students once a week for nine weeks. The sessions last from 45 minutes to one hour. Romano said that many of the kids she dealt with came from broken families, had absent fathers or had even seen fellow students seriously injured in gun or knife attacks. One student she worked with missed a few sessions and she later found out that he had been stabbed in the stomach after school. “Some of them literally negotiate life and death,” said Romano, a 2009 SAIS graduate who is now working toward a doctorate at the Chicago School of Professional Psychology. “We try to help them understand that they have a lot more control over their reactions and lives than they think.” Romano is originally from Los Angeles and is white and blonde. She said it took
kins University School of Medicine. “What our study says is that if you’re in good health and you’re over 70, you’re not too old to donate a kidney to your child, your spouse, your friend, anybody. “It’s better if you have a younger donor,” Segev acknowledged, “but not everyone has a younger donor. And an older live donor is better than no live donor at all.” A report on Segev’s research, published online in the Clinical Journal of the American Society of Nephrology, describes analysis of records from the 219 living people over 70 who donated a kidney in the United States between 1990 and 2010. The team matched those donors with healthy people in the same age group and found that the donors actually lived longer than those who had both their kidneys. Segev attributes the longevity to the probability that people who donated kidneys are healthy to begin with or surgeons wouldn’t
allow them to give up an organ. Also, after donation, they may be more likely than the typical person their age to regularly visit a physician and work hard to stay healthy. More than 90,000 patients are on the waiting list for kidneys from deceased donors in the United States, and many die waiting for an organ to become available. In some parts of the country, the wait for a kidney can be as long as 10 years, and those who can often turn to living donors, both relatives and friends, to ask for organs. People can function normally with one working kidney. For many people the option may be either to wait as long as 10 years—with a high risk of death during that period—or to find a living donor, even if that donor is over 70, Segev said. A kidney from a living donor over the age of 70 is likely to last as long as a kidney from a younger deceased donor, he said, “and the transplant can occur right away rather than 10 years from now.”
People over the age of 70 make up only a small percentage of live donors, but Segev said that their numbers have been steadily rising, tripling in the past 20 years. Segev said he hopes that this research will help older people understand that age may not be a barrier to organ donation. “There are many healthy older adults out there who have loved ones in need of a kidney but are not aware they may be able to donate,” he said. “It is reasonable for them to pursue donation and, if they are cleared by a transplant center, it is safe for them to undergo donation.” Other Johns Hopkins authors contributing to the study are Jonathan C. Berger, Abimereki Muzaale, Jacqueline M. Garonzik Wang, Robert A. Montgomery, Allan B. Massie and Erin C. Hall. —Stephanie Desmon
about a month to earn a level of trust from the students, who are mostly from inner cities and African-American. “We had our own negotiation of space,” she said. “They also all assumed we were getting paid for our time with them. When we told them we weren’t, they said, ‘Then why the heck are you here?’ We said we just wanted to learn and share with you guys, and that changed their perspective somewhat.” SAIS student Jennifer Fishkin said that many of the children deem the use of violence an appropriate response. “It’s difficult for them to value using nonviolence over violence, how to take the time to not hit someone or lash out,” said Fishkin, who is working with seventh-graders at Eliot-Hine Middle School, this year’s location for the program. In one session this semester, the SAIS students put up maps of the world and the middle school and asked the students to mark where conflicts start. On the school map, many denoted the lunchroom, a frequent scene of food fights. “This is an example of a conflict that escalates,” Fishkin said. “And we asked them if they could change anything so that it wouldn’t.” The program teaches the adolescents the “three R’s” of confliction resolution: recognize, respect and resolve. In the first stage, the children define what a conflict is and learn to identify conflicts in their daily lives, such as prejudice and stereotypes. In the next phase, they learn to better identify their emotions and appreciate the role that emotions play in everyday conflicts. Lastly, they learn conflict resolution skills and strategies. The goal is to promote the power of communication and have the participants develop a better awareness of self and others. “They negotiate identity issues all the time,” Romano said. “What group or clique of kids do they want to be part of or associated with? I felt it was my goal as a teacher to help create the space to experience that understanding and use it to their advantage.” The students have opportunities for selfreflection in the journals they write and the art they are sometimes asked to create. Romano remembers one student drawing a picture of a sailboat with a black outer rim and a blood-red interior. “Psychologically, that one image contained a lot,” she said. In one PeaceKidZ scenario, students are presented with someone rushing toward them in an aggressive mode. How do they respond? They are also asked about conflicts at home, even relatively minor issues such as sharing items with a sibling. “We try to put things in ‘I’ terms,” Zartman said. “This is what you want, and this is what I want. State your position and let’s work it out together. Instead of resorting to hostility, you back off.” The students, Zartman said, often worry about “loss of face.” “When someone challenges you and you
back off, that can be labeled as weakness,” he said. “We try to help them learn how to handle the situation and that kind of attitude. You back off strongly and tell them, I’m not going to fight with you—there are better ways to handle this. Maybe it’s walking away, but not running away.” The program has been implemented in a number of institutions in the D.C. area, including Francis C. Hammond Middle School, Andrew Jackson Middle School, Renaissance Christian Academy and the District of Columbia YMCA, as well as SunRise Academy and Eliot-Hine. This semester, eight students are enrolled in the course, six from SAIS and two from American University. Zartman said that the PeaceKidZ experience is often an eye-opening one for the SAIS students. He said that roughly one-
third of the students are internationals and are “bowled over” when they see the American school system firsthand. “No matter how much we prepare them, they are still very surprised to see how different it is from what they are accustomed to,” he said. “They see the relative lack of barriers between students and teachers, and teachers relating to students.” Romano said that her time with PeaceKidZ was one of her most valuable experiences at SAIS. “I was able to be so deeply hands-on with these kids,” she said. “I thought I was going into a classroom setting to resolve conflicts. They taught me a heck of a lot more.” She’s kept in touch with one student and attended a play he co-wrote, which contained many conflict mangement themes. He is attending George Mason University and doing well, she said. G
Printing Services Finds Beauty in the Details On the Homewood campus is an incredible university resource with the capacity for customized high-volume copy work, short-run printing and everything in between. Where Printing Services really shines, though, is in its attention to detail. Just ask. Its professionals know printing and duplicating, but even better, they know Johns Hopkins University and how important your work is. Make Printing Services—a part of Marketing & Creative Services— your destination for copying and printing solutions. To find out how Printing Services can help you with your next project, visit web.jhu.edu/printingservices or contact Ann Grattan at aeg@jhu.edu.
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6 2011 6 THE THE GAZETTE GAZETTE •• November August 15, 14, 2011
New partnership puts Conservatory students on the big stage By Richard Selden
Peabody Institute
T
he Peabody Opera Theatre will present Stravinsky’s The Rake’s Progress this weekend in the historic Baltimore theater now known as the Patricia and Arthur Modell Performing Arts Center at The Lyric. The inaugural season of Lyric Opera Baltimore—the successor to the Baltimore Opera Company, which ceased operations
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in 2009—opened on Nov. 4 with La traviata and includes Le Nozze di Figaro and Faust. As a 20th-century work sung in English, the Peabody production of The Rake’s Progress is a distinctive complement to the opera company’s season. “The mounting of our fall opera in the newly modernized 2,500-seat Lyric marks the beginning of a true partnership,” said Jeffrey Sharkey, director of Johns Hopkins’ Peabody Institute. The new, fully staged production of The Rake’s Progress is directed by faculty member Garnett Bruce, who recently directed Turandot for San Francisco Opera and Lyric Opera of Kansas City and Lucia di Lammermoor for The Dallas Opera. Luke Cantarella, head of scene design at the University of California, Irvine, is the production designer. Hajime Teri Murai, the Ruth Blaustein Rosenberg Director of Orchestral Activities at Peabody, will conduct the Peabody Symphony Orchestra. The Rake’s Progress, with a libretto by W.H. Auden and Chester Kallman, had its premiere in 1951 at the Venice Biennale. It was inspired by a series of eight bitingly satirical paintings by 18th-century English artist William Hogarth, one of several groups depicting “modern moral subjects” that became popular sets of engravings. The word “progress,” usually associated with a royal tour or a religious journey—as in The Pilgrim’s Progress—is here the tragicomic descent of Tom Rakewell into sin and madness. Noting that the opera is “very contemporary [and] not a costume drama,” Bruce explains that “Stravinsky was challenging himself to use classical structures in a modern society.” In light of the new venue, Peabody’s production of The Rake’s Progress will be performed twice rather than four times and single- rather than double-cast. The leads are Peter Drackley, a senior studying
JAMES LIGHTNER
Peabody Opera Theatre to present Stravinsky’s ‘The Rake’s Progress’
Taylor Armstrong as Tom Rakewell in Act II, scene 1 of Peabody Opera Theatre’s upcoming production of ‘The Rake’s Progress.’
with Phyllis Bryn-Julson, as Tom Rakewell (“a Rake”); Kisma Jordan, a Graduate Performance Diploma candidate studying with Stanley Cornett, as Anne Trulove
(“his Betrothed”); Peter Tomaszewski, a Graduate Performance Diploma candidate studying with John Shirley-Quirk, as Nick Shadow (“a Devilish Manservant”); and Kristina Lewis, a Graduate Performance Diploma candidate studying with Stanley Cornett, as Baba the Turk (“a Bearded Lady”). The production also features a chorus of graduate singers from the Conservatory. “They are all soloists in their own right, taking roles ranging from whores in a brothel to madmen in Bedlam,” said Roger Brunyate, artistic director of the Peabody Opera Theatre. The Rake’s Progress is sponsored by Dr. and Mrs. Allan D. Jensen with additional funding provided by Marc von May. Performances are at 7:30 p.m. on Friday, Nov. 18, and at 3 p.m. on Sunday, Nov. 20. Tickets are $35 and $25. The Peabody Opera Theatre’s spring production, The Crucible by Robert Ward, will be presented March 14 to 17 in Peabody’s Miriam A. Friedberg Concert Hall with the Peabody Concert Orchestra conducted by JoAnn Kulesza. Brunyate is the production’s director and designer. To purchase tickets for The Rake’s Progress, go to www.lyricoperahouse.com or call 410900-1150. For the complete Peabody events calendar, go to www.peabody.jhu.edu/events.
JHH wins 16th straight Consumer Choice Award
F
or the 16th straight year, The Johns Hopkins Hospital has received the Consumer Choice Award from the National Research Corp., a firm that specializes in health care performance measurement and improvement. The award recognizes hospitals that health care consumers have chosen as having the highest quality and image in more than 300
markets throughout the United States. This is the 16th year that the NRC has awarded hospitals across the nation. The Johns Hopkins Hospital was the top-ranked hospital in the Baltimore-Towson, Md., Core Based Statistical Areas, a market that comprises Baltimore City and Anne Arundel, Baltimore, Carroll, Harford, Howard and Queen Anne’s counties.
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November 14, 2011 • THE GAZETTE
7
Peroxide-producing gene could be potential target for chemoprevention B y V a n e s s a W a s ta
Johns Hopkins Medicine
W
orking with lab cultures and mice, Johns Hopkins scientists have found that a strain of the common gut pathogen Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase, or SMO, in the intestine. The effect is to expose the gut to hydrogen peroxide—the caustic, germ-fighting substance found in many medicine cabinets—and cause DNA damage, contributing to the formation of colon tumors, the scientists say. “Our data suggest that the SMO gene and its products may be one of the few good targets we have discovered for chemoprevention,” said Robert Casero, professor of oncology at the Johns Hopkins School of Medicine and the Johns Hopkins Kimmel Cancer Center. In a study, Casero and his colleagues introduced B. fragilis to two colon cell lines and measured SMO gene activity. In both cell lines, SMO gene activity increased two to four times higher than in cells not exposed to the bacteria. The scientists also observed similar increases in enzymes produced by the SMO gene. The scientists successfully prevented DNA damage in these cells by blocking SMO enzyme activity with a compound called MDL 72527. The team also tested its observations in a mouse model, created by Johns Hopkins infectious disease specialist Cynthia Sears to develop colon tumors. Mice exposed to the bacteria had similar increases in
SMO. Mice treated with MDL 72527 had far fewer tumors and lower levels of colon inflammation than untreated mice. Results of the experiments were published online in August in the Proceedings of the National Academy of Sciences. Casero says that hydrogen peroxide can freely distribute through and into other cells. “It roams around, and can damage the DNA in cells,” he said. Andrew Goodwin, who spearheaded the studies while performing graduate work in Johns Hopkins’ Cellular and Molecular Medicine Program and in Casero’s laboratory, says that rising levels of hydrogen peroxide and DNA damage in the colon are clear steps to tumor development. B. fragilis strains that secrete a toxin are widely known to cause diarrhea in children and adults, and previous studies, including those at Johns Hopkins, have linked the toxin-producing bacteria to inflammation and colon cancer. Casero and collaborators previously linked the SMO gene to inflammation and cancer of the prostate and stomach. Using MDL 72527 in humans is not advised, Casero says, because the compound blocks another enzyme in addition to SMO. Investigators hope to develop a drug that targets only the SMO enzyme. Candidates for such prevention strategies may include people with a history of colon polyps, which increases risk for colon cancer, and those with inflammatory bowel disease. Funding for the research was provided by the Samuel Waxman Cancer Research Foundation and the National Institutes of Health. In addition to Casero, Goodwin and Sears, scientists who contributed to the research are Christina E. Destefano Shields, Shaoguang Wu, David L. Huso, XinQun Wu, Tracy R. Murray-Stewart, Amy Hacker Prietz and Shervin Rabizadeh, all of Johns Hopkins; and Patrick M. Woster, of the Medical University of South Carolina.
JAY VANRENSSELAER / homewoodphoto.jhu.edu
Common bacteria cause some colon tumors by altering a gene
Imagining their new community school
O
n a beautiful fall day last week, students of East Baltimore Community School walked five blocks to the site of their new school building, scheduled to open in August 2013. Students posted their dreams for the future, which were written on 3 x 5 cards, on the fence surrounding the site and performed a ribbon-cutting ceremony that marked the
beginning of the demolition phase of the project. Construction will start in the spring. The Johns Hopkins School of Education is the operator of EBCS in partnership with Morgan University School of Education. Children of Johns Hopkins employees in East Baltimore are eligible for enrollment in the school, which will be located on a sevenacre campus just north of the university’s medical campus. —James Campbell
JHH contractors turn over keys to new facility
T
he Johns Hopkins Hospital becomes the official owner today of the new 1.6 million-square-foot facility that will house the Sheikh Zayed Tower and Charlotte R. Bloomberg Children’s Center. At 12:30 p.m., construction company officials will hand over a ceremonial key to Edward D. Miller, dean of the School of Medicine and CEO of Johns Hopkins Medicine, and Ronald R. Peterson, president of The Johns Hopkins Hospital and Health System. The new buildings will open to patients on April 29, 2012.
The transfer of the keys will take place during a 10 a.m. to 3 p.m. employee event where staff will receive information about the new buildings and see virtual tours, photos and videos. The event marks a major milestone toward the opening of the facility, which will have 560 all-private patient rooms, 33 operating rooms, state-of-the-art imaging equipment and emergency departments for adults and children, among other features. It also will house the Johns Hopkins Heart and Vascular Institute.
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8 2011 8 THE THE GAZETTE GAZETTE •• November August 15, 14, 2011
J
Sickle cell community forum to educate, empower patients
ohns Hopkins Medicine last week brought together community members to develop a communications campaign to engage patients, health care professionals and legislators in the fight against sickle cell disease. “Linking Awareness to Action”—a dinner, panel and group discussion—was the first of a four-part community forum series to educate and empower individuals living with sickle cell disease, a painful and disabling inherited blood disorder that affects mostly African-Americans.
“Many sickle cell patients feel like they don’t have a voice because a lack of understanding of the disease has led to stigma and misperceptions,” said Sophie Lanzkron, director of the Sickle Cell Center for Adults at Johns Hopkins. “We’re trying to overcome that and encourage patients and their families to be better advocates for themselves.” Participants will develop strategies to improve sickle cell care, such as seeking primary care doctors who can help them to better manage pain and day-to-day health needs.
N O V .
From developing hydroxyurea, the only drug approved by the FDA for the treatment of sickle cell disease, to current research that uses a patient’s own stem cells to correct the genetic alteration that causes the disease, Johns Hopkins Medicine has a strong history and commitment of improving care for sickle cell patients. The Johns Hopkins Sickle Cell Infusion Center, which opened in 2008, acts as an urgent care center where patients can experience pain relief more quickly. These earlier interventions lead to reduced discomfort and risk of hospital admission, which
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Calendar chemistry and Molecular Biology seminar with David Greenstein, University of Minnesota. W1020 SPH. EB
Integrated Neonatal and Postpartum Family Planning Program in Sylhet, Bangladesh,” an International Health thesis defense seminar with Savitha Subramanian. W2030 SPH. EB
Mon., Nov. 14, 12:15 p.m. “Synthetic Cell Biology: Visualizing and Manipulating Cell Signaling,” a Carnegie Institution Embryology seminar with Takanari Inoue, SoM. Rose Auditorium, 3520 San Martin Drive. HW
Wed., Nov. 16, noon. “PBX1, a New Pioneer Factor Predictive of Endocrine Therapy Resistance in Breast Cancer,” a Pathology seminar with Mathieu Lupien, Dartmouth Medical School. G01 BRB. EB
Mon.,
Wed., Nov. 16, noon. “Structure and Mechanism of Bacterial NhaA,” a special Physiology seminar with Etana Padan, Hebrew University, Jerusalem. 203 Physiology. EB
Continued from page 12
Nov.
14,
12:15
p.m.
“Berman Institute of Bioethics Noon Seminar—“Post Trial Obligations—Where Do We Stand?” with Christine Grady, NIH Clinical Center. E2030 SPH. EB
“Unraveling the Specificity of Heparanase Utilizing Synthetic Substrates,” a Biological Chemistry seminar with Sherket Peterson, University of North Carolina, Chapel Hill. 612 Physiology. EB
“Holomorphic Extensions and the Complex Monge-Ampere Equation,” an Analysis/PDE seminar with Dan Burns, University of Michigan. Sponsored by Mathematics. 300 Krieger. HW
Wed., Nov. 16, noon.
Tues.,
Wed., Nov. 16, 12:15 p.m.
Mon., Nov. 14, 4 p.m.
Nov.
15,
12:10
p.m.
“Legislative Mandates in Injury Prevention: Impact of the Needlestick Safety and Prevention Act,” a Graduate Seminar in Injury Research and Policy with Elayne Kornblatt Phillips, University of Virginia. Co-sponsored by Health Policy and Management, the Center for Injury Research and Policy, and the Education and Research Center for Occupational Safety and Health. W2017 SPH. EB The M. Gordon Wolman Seminar— “Investigating Atmospheric-Terrestrial-Hydrologic Interactions of Reactive Nitrogen Using Stable Isotope Geochemistry” with Emily Elliott, University of Pittsburgh. Sponsored by Geography and Environmental Engineering. 234 Ames. HW Tues., Nov. 15, 3 p.m.
Tues.,
Nov.
15,
4:30
p.m.
“Object Detection Grammars,” a Center for Language and Speech Processing seminar with David McAllester, Toyota Technological Institute at Chicago. B17 Hackerman. HW Wed., Nov. 16, 9:30 a.m. “An Evaluation of the Quality of Counseling Provided by Community Health Workers in an
Mental Health Noon Seminar— “A Map of Global Mental Health: Where Do You Fit In?” with Amy Daniels, Rebecca Hock and Flora Or, all of SPH. B14B Hampton House. EB Wed.,
Nov.
16,
1:30
p.m.
“Structural Studies of the Intact 712 Nucleotide HIV-1 RNA Packaging Signal by NRM Spectroscopy,” a Biophysics and Biophysical Chemistry seminar with Michael Summers, UMBC. 701 WBSB. EB Wed., Nov. 16, 4 p.m. “New Paradigms for Protein Acetyltransferases,” a Pharmacology and Molecular Sciences seminar with Ronen Marmorstein, The Wistar Institute. West Lecture Hall (ground floor), WBSB. EB Wed., Nov. 16, 4 p.m. “Learning Discrete Graphical Model Structure,” a Biostatistics seminar with Pradeep Ravikumar, University of Texas, Austin. W2030 SPH. EB Thurs., Nov. 17, 10:45 a.m.
“Computational Challenges of Next-Generation Genomics,” a Computer Science seminar with Steven Salzberg, SoM. B17 Hackerman. HW
also translates to decreased spending. The treatment of a typical sickle cell patient costs 30 times more than a congestive heart failure patient because of recurrent emergency department visits prompted by chronic pain. The event, held in the Koch Cancer Research Building, was sponsored by the Department of Medicine’s iHOMES Network, the Sickle Cell Center for Adults at Johns Hopkins and the School of Medicine Office of Diversity and Cultural Competence.
Special Bodian Seminar—“Neural Representation of Surface Reflectance Properties” with Hidehiko Komatsu, National Institute for Physiological Sciences, Japan. Sponsored by the Krieger Mind/ Brain Institute. 338 Krieger. HW
T h u r s . , N o v. 1 7 , n o o n .
Thurs., Nov. 17, noon. “In vivo Biology of Malaria Transmission Stages,” a Molecular Microbiology and Immunology/Infectious Diseases seminar with Matthias Marti, Harvard University. W1020 SPH. EB
“Membrane and Cortical Dynamics in Mammalian Eggs: Implications for Reproductive Success,” a Cell Biology seminar with Janice Evans, SPH. Suite 2-200, 1830 Bldg. EB
Thurs., Nov. 17, noon.
Thurs., Nov. 17, noon. The Bromery Seminar—“Climate Change Mitigation: International Imperative and Academic Responsibility” with George Stone, Milwaukee Technical College. Olin Auditorium. HW Thurs., Nov. 17, 1 p.m. “Use of Serological Surveillance With Oral Fluid and Blood to Monitor Measles Vaccination Coverage in a Rural District of Bangladesh,” an International Health thesis defense seminar with Kyla Hayford. W2030 SPH. EB Thurs., Nov. 17, 4 to 6 p.m., and Fri., Nov. 18, 9 a.m. to 12:30 p.m. The Futures Semi-
the Krieger Mind/Brain Institute. 338 Krieger. HW “An Effect of a First-Order Chemical Reaction on Turbulent Scalar Transfer Into a Turbulent Liquid Across a Gas-Liquid Interface,” a CEAFM seminar with Ryuichi Nagaosa, National Institute of Advanced Industrial Science and Technology, Japan/University of Maryland. 50 Gilman. HW
Fri., Nov. 18, 11 a.m.
Special Bodian Seminar—“Spaces Within Spaces: The Different Forms by Which Parietal Cortex, Premotor Cortex and Hippocampus Map Position in Three Spatial Reference Frames” with Douglas Nitz, University of California, San Diego. Sponsored by the Zanvyl Krieger Mind/Brain Institute. 338 Krieger. HW Fri.,
Nov.
18,
noon.
“The Association Between Depression and Mortality in the General Community,” an Epidemiology thesis defense seminar with Lisa Wyman. W1020 SPH. EB
Fri., Nov. 18, noon.
Special Bodian Seminar—“Mechanisms of Adaptation of Spiking Activity and Local Field Potentials in Macaque Inferior Temporal Cortex” with Rufin Vogels, Leuven University, Belgium. Sponsored by the Zanvyl Krieger Mind/Brain Institute. 338 Krieger. HW
Fri., Nov. 18, 2 p.m.
Mon., Nov. 21, 1:30 p.m. “Predicting the Impact of Mutations in Cancer Using an Integrated Pathway Approach,” a Biomedical Engineering seminar with Josh Stuart, University of California, Santa Cruz. 110 Clark. HW (Videoconferenced to 709 Traylor. EB ) Tues.,
Nov.
22,
12:10
p.m.
HW
“Case Crossover Methods to Identify Risk Factors for Meatpacking Laceration Injuries,” a Graduate Seminar in Injury Research and Policy with Melissa Perry, George Washington University School of Public Health and Health Services. Co-sponsored by Health Policy and Management, the Center for Injury Research and Policy, and the Education and Research Center for Occupational Safety and Health. W2017 SPH. EB
The David Bodian Seminar— “The Neuronal Mechanisms of Declarative Memory Formation in the Human Medial Temporal Lobe” with Ueli Rutishauser, Max Planck Institute for Brain Research, Germany. Sponsored by
Mon., Nov. 28, 12:15 p.m. “Poly ADP-ribose Polymerase in Chromatin and Transcriptional Regulation,” a Carnegie Institution Embryology seminar with Alexei Tulin, Fox Chase Cancer Center. Rose Auditorium, 3520 San Martin Drive. HW
nar—The International Studies Program, with Jelke Boesten, U.S. Institute of Peace, and Patrick Thaddeus Jackson, American University. Mason Hall Auditorium (Thursday) and Charles Commons (Friday). HW Thurs., Nov. 17, 4 p.m. “Polarity Protein Dynamics and Hypoxia,” a Biology seminar with Yang Hong, University of Pittsburgh School of Medicine. 100 Mudd.
Thurs., Nov. 17, 4 p.m.
SPECIAL EVENTS
Eid AlAdha banquet to mark the end of the Muslim pilgrimage to Mecca, sponsored by the Johns Hopkins Graduate Muslim Students Association and the JHSPH Student Assembly. Open to the general public. Dinner will be provided. Tilghman Auditorium, Turner Concourse. EB
Tues., Nov. 15, 6 p.m.
Tues., Nov. 15, 8 p.m. The 2011 Milton S. Eisenhower Symposium—America’s Boundless Possibilities: Innovate, Advance, Transform, with Karl Rove, adviser to former President George W. Bush. The talk will be followed by a question-and-answer session and reception. Shriver Hall Auditorium. HW Sun., Nov. 20, 4 to 6 p.m.
Digital Media Center Artist’s Talk, with visual and performance artist and musician Jacob Ciocci, and musician, composer and scholar Tara Rodgers. Cosponsored by JHU Digital Media Center and the JHU Baltimore Curators’ Series. 101 Mattin Center. HW
W OR K S H O P S
Tues., Nov. 15, 9 a.m. to 3:30 p.m. “Food Information Day,” a
Center for Alternatives to Animal Testing workshop focusing on risk assessment and management for food. U.S. and EU speakers from industry, government and academia will explore issues of food safety, animal health, international regulations and 3Rs approaches to these issues. Cosponsored by the Orange House Partnership. For program details and registration information, go to caat.jhsph.edu/programs/ workshops/foodinformation.html. E2030 SPH. EB Tues., Nov. 15, 1:30 p.m. “Evaluation to Improve Instruction,” an Eyes on Teaching workshop open to all grad students, postdoctoral fellows, lecturers and faculty in KSAS or WSE. To register, go to www.cer.jhu.edu/events .html. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW
“Introduction to Facebook,” a Bits & Bytes workshop. The training is open to full-time Homewood faculty, lecturers and TAs; staff are also welcome to attend. To register, go to www.cer.jhu.edu/events .html. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW
Thurs., Nov. 17, 1 p.m.
November 14, 2011 • THE GAZETTE
9
Combo ‘epigenetic’ therapy may restore anti-cancer gene activity Johns Hopkins Medicine
A
new type of therapy aimed at reversing the gene silencing that promotes cancer-cell growth has shown promising results in a small clinical trial conducted by researchers at the Johns Hopkins Kimmel Cancer Center. Forty-five latestage lung cancer patients who received a two-drug combination designed to restore anti-cancer gene activity survived about two months longer than the expected four months, and two patients showed complete or near-complete responses despite having progressive disease after multiple standard therapies. In the study, reported in Cancer Discovery Nov. 9, the researchers treated non-smallcell lung cancer patients with a combination of the drugs azacitidine and entinostat. Azacitidine removes methyl groups from genes; entinostat inhibits histone deacetylation, a closely related process that also contributes to gene silencing. “We hope these results lead to a larger, more definitive clinical trial of this drug combination,” said Charles Rudin, a professor of oncology and director of the Upper Aerodigestive Cancer Program at the Kimmel Cancer Center. Rudin led the team of physicians and cancer biologists who conducted the study, which is believed to be one of the first to show promising results for
“epigenetic” anti-cancer therapies in solid tumors. Johns Hopkins researchers previously tested the drug combination in leukemia patients. Laboratory results suggest that epigenetic treatments aim not to kill cancer cells directly but instead may reprogram their patterns of gene expression so that they lose their capacity for uncontrolled growth. A normal cell has a specific pattern of gene expression, in which some genes are active and others are suppressed, and a derangement of this pattern frequently contributes to cancer, in part by silencing genes whose activity would normally stop a cell from becoming cancerous. Cancer cells also have permanent genetic mutations, which cannot be undone with drugs, but in many cases they may achieve similar cancer-promoting effects through mutations and epigenetic gene silencing. The trial was based in part on the results of a study reported in the New England Journal of Medicine in 2008 by a group of Johns Hopkins researchers, led by Malcolm Brock and including cancer epigenetics experts Stephen Baylin, the Virginia and D.K. Ludwig Professor for Cancer Research and deputy director of the Kimmel Cancer Center; and James Herman, a professor of oncology. In that study, the researchers found that early-stage non-small-cell lung cancer is much more likely to recur after surgery if the tumor and nearby lymph nodes contain gene-silencing markers known as methyl groups on at least two of four key genes.
Demo, discussion of ‘green’ transportation set for Tuesday By Phil Sneiderman
Homewood
D
emonstrations of new fuel-efficient vehicles and a discussion of “green” transportation technology will take place Tuesday, Nov. 15, on the Homewood campus. The event was organized by Ford Motor Co., the Johns Hopkins Sustainability Office and the Baltimore Electric Vehicle Initiative. Speaking and fielding questions between 11:30 a.m. and 12:30 p.m. in the Mason Hall Auditorium will be Cynthia Williams, environmental policy manager at Ford; Davis
Carey/MICA Continued from page 1 sustained immersion in the creative process grounded in a proven business curriculum, graduates from this program will be prepared to engage and lead organizations in the discovery of fresh and innovative solutions to real-world challenges.” The new offering will enable students to: • Earn an MBA/MA in Design Leadership in an 18- to 20-month 66-credit program of study and gain double the skill sets of a traditional MBA program in a compressed period of time. • Enhance in-depth knowledge in diverse areas that include strategy, finance, statistics, economics, ethics, law, marketing, operations and human capital management, along with visualization, prototyping, cultural relevance and awareness, design theory, sustainability and social responsiveness. • Develop expertise in strategy formulation, audience targeting, research and design thinking through a collaborative, multidisciplinary approach to problem solving. • Study in a cohort of peers with a broad array of expertise and knowledge. • Learn through educational experiences that immerse students in real-world situa-
Bookhart, director of the Johns Hopkins Sustainability Office; and Jill A.T. Sorensen, executive director of the Baltimore Electric Vehicle Initiative. After the discussion, a light lunch will be served, and attendees will have an opportunity to view demonstrations and take test drives in vehicles drawn from Ford’s fuel-efficient offerings and the new electrified vehicles that will be available in North America by 2012 and Europe by 2013. The vehicles—the Focus Electric, Transit Connect Electric, Fiesta, Explorer with EcoBoost and Fusion Hybrid—will be parked in the driveway outside Mason Hall. tions presented by companies, nonprofits, government entities and individuals. While most business programs focus solely on the mastery of traditional business practices, the MBA/MA in Design Leadership takes business leadership a step further, integrating an approach to meeting challenges that centers on making connections between ideas, resources and people that might not appear obvious. Graduates will be able to imagine ways to leverage opportunities that break standard molds of business practices and create new expectations among customers, companies and the public. As business leaders, they will be prepared to test assumptions while combining both intuitive and logical approaches and working collaboratively within interdisciplinary teams to solve complex problems through iterative processes. Students will come from backgrounds that include business management, marketing, engineering, finance, art and design, architecture, fine arts and other fields. Successful candidates will have an interest in becoming a leader in commerce, a desire to grasp both business practices and the principles of problem solving used by designers and creative individuals, strong writing and communication skills, the ability to work in teams and collaborate with individuals from multiple fields, and enthusiasm for multidisciplinary study and research. G For more about the program, go to www .designleadershipmba.com.
“We showed in the late 1990s that if you got rid of the abnormal DNA methylation first, and then used a histone deacetylase inhibitor, you could enhance the re-expression of these abnormally silenced genes,” Baylin said. The new study enrolled 45 patients with metastatic non-small-cell lung cancer that had progressed after earlier standard therapies. Initial tests of the drugs in 10 patients established that the planned doses did not cause unacceptable side effects, and eventually another 35 patients were treated. Each received azacitidine on nine days and entinostat on two days per month. The trial had an “open label” design, meaning that all patients received the treatment and there was no control group receiving a placebo. Such trials are often used in early clinical investigations of cancer drugs, Rudin said, because the patients who receive them typically have life expectancies of six months or less and have relatively few good treatment options. As noted earlier, median survival of all patients treated with the combination epigenetic therapy was two months longer than the four months normally expected. Patients who showed signs of gene methylation reversal in at least two of four key genes had better survival than the rest, and two patients experienced dramatic tumor shrinkages. “One patient’s tumor appeared to have a complete response,” Rudin said. That patient, who formerly had smoked, survived for nearly three years before succumbing to a different lung tumor. In another patient, a man whose metastasizing lung tumors had spread to his liver, the epigenetic treatment cleared his metastases and markedly reduced his original lung tumor. “That patient is, in fact, still alive, two and a half years after getting the epigenetic therapy,” Rudin said. In addition to showing that the combination epigenetic therapy is well-tolerated and can be effective, the study, Rudin said, suggests that the silencing status of these four key genes may represent a “biomarker” of benefit from the combination therapy in non-small-cell lung cancer. It also suggests, he said, that the combination of azacitidine and entinostat can show favorable epigen-
etic effects at much milder doses than the cell-killing doses at which azacitidine was originally used in cancer patients. One further hopeful result of the study was the observation that following their epigenetic drug therapy, a number of patients showed unexpectedly strong responses to further treatment with standard chemotherapies. “This raises the possibility that the epigenetic treatment is having a delayed effect, or is even sensitizing patients’ tumors in a way that makes them more vulnerable to subsequent therapies,” Baylin said. The Johns Hopkins researchers said that they are approaching the manufacturers of the drugs to develop additional studies. One such study has been launched, testing this combination in patients with earlystage cancers that have been surgically removed. The study was funded by the National Institutes of Health SPORE Program, the Flight Attendant Medical Research Institute and a Stand Up to Cancer Award from the American Association for Cancer Research in association with the Entertainment Industry Foundation. Additional scientists contributing to the research were Rosalyn A. Juergens, formerly of the Johns Hopkins Kimmel Cancer Center and currently at McMaster University; Brock, John Wrangle, Frank P. Vendetti, Sara C. Murphy, Ming Zhao, Barbara Coleman, Rosa Sebree, Kristen Rodgers, Craig M. Hooker, Noreli Franco, Beverly Lee, Salina Tsai, Michelle A. Rudek and Herman, all of Johns Hopkins; Igor Espinoza Delgado, of the National Cancer Institute; and Steven A. Belinsky, of the Lovelace Respiratory Research Institute. Juergens and Rudin previously consulted for Syndax Pharmaceuticals, manufacturer of entinostat. Herman has previously consulted for MDx Health, which licensed Johns Hopkins–invented technology on a methylation-specific PCR method to identify gene methylation status; Herman and Brock have research support from MDxHealth; and Herman, Brock and Baylin hold a patent licensed to MDx Health. These arrangements are being managed by The Johns Hopkins University in accordance with its conflict-of-interest policies.
LAUREN PRELLER
B y V a n e s s a W a s ta
Gregory C. Pappas, Hellenic Students Association President George Petrocheilos and Nick Tsakalos.
Greek night at the Walters
T
he Johns Hopkins Hellenic Students Association and the Walters Art Museum last week co-hosted a presentation of the museum’s Lost & Found: The Secrets of Archimedes exhibit for an intimate gathering of members of the city’s Greek community and out-of-town guests. Among the 70 attendees were U.S. Rep. John Sarbanes; Gregory C. Pappas, president of the Greek America Foundation, from Chicago; Nick Tsakalos, co-owner of H&S Bakery; Aris Melissaratos, senior adviser to the president of Johns Hopkins and former Maryland secretary of business and economic
development; Paul Kotrotsios, president of the Hellenic American National Council, from Pennsylvania; Chrys P. Kefalas, former deputy legal counsel of the state of Maryland; and Jason Filippou, executive director of the Greektown Community Development Corp. The evening—which included a talk by curator William Noel, a tour of the exhibition and a reception—was the result of extensive outreach efforts by George Petrocheilos, president of the Hellenic Students Association. Petrocheilos co-hosted the event with Anna Z. Pappas, a longtime patron of the Walters.
10 2011 10 THE THE GAZETTE GAZETTE •• November August 15, 14, 2011 H U M A N
R E S O U R C E S
No notices were submitted for publication this week.
Listed below are some of the university’s newest openings for indemand jobs that we most urgently need to fill. In addition to considering these opportunities, candidates are invited to search a complete listing of openings and apply for positions online at jobs.jhu.edu.
Office of Human Resources Wyman Park Building, Suite W600 410-516-7196
By Audrey Huang
If you have experience with programs for academically advanced young people and/or distance education, we have several openings at our Center for Talented Youth. The CTYOnline Program offers about 60 different courses to eligible students around the world, with about 9,000 enrollments a year. For detailed job descriptions and to apply, go to jobs.jhu.edu. CTY Academic Program Coordinator CTY Assistant Program Manager CTY Distance Education Instructor, Computer Science CTY Outreach Coordinator CTY Assistant Program Manager
School of Medicine Office of Human Resources 98 N. Broadway, Suite 300 410-955-2990 The School of Medicine currently has several RN and mid-level provider vacancies, all of which strive to provide compassionate, state-of-the-art patient care. To see full job descriptions and to apply, go to jobs.jhu.edu. Nurse Practitioner Nurse Practitioner/Physician Assistant Nurse Practitioner/Physician Assistant Senior Research Nurse Certified Registered Nurse Anesthetist Senior Research Nurse Clinical Nurse
Schools of Public Health and Nursing Office of Human Resources 2021 E. Monument St. 410-955-3006 The Bloomberg School of Public Health is seeking skilled applicants for several parttime and on-call administrative coordinator positions. We are looking for individuals who possess good computer, organizational and communication skills. For detailed job descriptions and to apply, go to jobs.jhu.edu. 50426 50157
Administrative Coordinator Administrative Coordinator
Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria.
Woodcliffe Manor Apartments
S PA C I O U S
G A R D E N A PA RT M E N T L I V I N G I N
R O L A N D PA R K
• Large airy rooms • Hardwood Floors • Private balcony or terrace • Beautiful garden setting • Private parking available • University Parkway at West 39th St. 2 & 3 bedroom apartments located in a private park setting. Adjacent to Johns Hopkins University Homewood Campus and minutes from downtown Baltimore.
410-243-1216
Researchers discover how breast cancer spreads to lungs Johns Hopkins team also finds that digitalis can reduce lung metastases
Homewood
47930 48359 48977 49453 48174 50103 50163
B O A R D
Notices
Hot Jobs
50441 50212 49935 49917 49914
B U L L E T I N
105 West 39th St. • Baltimore, MD 21210 Managed by The Broadview at Roland Park BroadviewApartments.com
Johns Hopkins Medicine
T
he spread of breast cancer is responsible for more than 90 percent of breast cancer deaths. Now, the process by which it spreads—or metastasizes—has been unraveled by researchers at Johns Hopkins. Reporting in two papers, the researchers have discovered the switch that enables breast cancer cells to travel to and be received in the lungs. The results appear in two separate papers, one in the Sept. 12 issue of the Proceedings of the National Academy of Sciences Early Edition and the other in the Aug. 22 issue of Oncogene. “Metastasis transforms breast cancer from a local, curable disease to one that is systemic and lethal,” said Gregg L. Semenza, the C. Michael Armstrong Professor of Medicine, director of the Vascular Program in the Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins. “Metastasis was long thought a late event in cancer progression, but we have now shown metastasis to be an early event that is dependent on HIF-1.” Discovered by Semenza’s team nearly 20 years ago, the HIF-1 protein controls genes that enable cells to survive in low oxygen, such as cells in solid tumors. More recently, others have found that in patients with breast cancer, an increase in HIF-1 activity correlates with increase in metastasis and decreased survival. To uncover the role of HIF-1 in breast cancer metastasis to the lungs, the research team first looked at the lung, which is prepared for the arrival of metastatic cells by enzymes that are produced by the breast cancer cells. Using human breast cancer cells, the research team examined the genes that encode these enzymes and found regions where HIF-1 could bind to the DNA. Since HIF-1 is active in low oxygen, the team genetically engineered and reduced the amount of HIF-1 the cells could make, then examined how active the enzyme-producing genes were in cells grown in normal or low oxygen levels. They found that the cells were unable to produce these enzymes without HIF-1. The team next implanted some of these same human breast cancer cells—some that made normal amounts of HIF-1 and some that made reduced amounts—into mice and examined the lungs after 45 days. Compared with breast cancer cells that made normal amounts of HIF-1, those making less HIF-1 resulted in smaller tumors and fewer changes in the lung, leading the researchers to conclude that HIF-1 is critical for lung metastasis. In order for breast cancer cells to spread to lungs, they must leave the breast, enter blood vessels that lead to the lungs and exit those same vessels. “Blood vessels are pretty tight; a cell has to work pretty hard to get through the vessel wall,” Semenza said. “Since HIF-1 triggers the lung to prepare for arriving breast cancer cells, we wondered if HIF-1 also is involved in getting cells into and out of blood vessels.” Semenza’s team used breast cancer cells grown in low oxygen to examine the activity of 88 genes known to play a role in metastasis. Looking for genes that are turned on
in response to low oxygen, they found one called angiopoietin-like 4 and one called L1 cell adhesion molecule, known as ANGPTL4 and L1CAM for short. Further examination of the DNA around these genes revealed regions where HIF-1 could bind, and removing HIF-1 from cells rendered them unable to turn on the two genes. When breast cancer cells turn on ANGPTL4, it helps them travel through blood vessel walls, a process the team found by injecting these cells either with normal or “knocked down” levels of ANGPTL4 into mice and examining their lungs. Cells lacking HIF-1 and containing extra ANGPTL4 were better able to invade the lungs than cells without extra ANGPTL4, so the researchers concluded that ANGPTL4 promotes cell exit from blood vessels. And they found the same to be true for L1CAM. Lastly, a few years ago, Semenza’s team found that digitalis/digoxin, commonly used to treat irregular heartbeats, can block HIF-1 production and can stop liver and prostate cancer cells from growing. To see if digitalis could do the same with metastatic breast cancer, the researchers transplanted human breast cancer cells into mice. After two weeks, they gave the mice daily injections of digitalis or saline. They found both fewer and smaller lung metastases in mice treated with digitalis. “This is really exciting,” Semenza said. “The therapeutic range for digoxin is wellestablished, and our findings warrant clinical trials to determine if these doses are enough to sufficiently block HIF-1 and slow breast cancer growth and metastasis.” These studies were funded by the Emerald Foundation, National Institutes of Health, Johns Hopkins Institute for Cell Engineering, Croucher Foundation and Postdoctoral Training Program in Nanotechnology for Cancer Medicine. Authors on the PNAS paper are Carmen Chak-Lui Wong, Daniele Gilkes, Huafeng Zhang, Jasper Chen, Hong Wei, Pallavi Chaturvedi, Stephanie Fraley, Denis Wirtz and Semenza, all of Johns Hopkins; and Chun-ming Wong, Ui-Soon Khoo and Irene Oi-Lin Ng, all of the University of Hong Kong. Authors on the Oncogene paper are H. Zhang, C.C.L. Wong, H. Wei, DM Gilkes, P. Korangath, P. Chaturvedi, L. Schito, J. Chen, B. Krishnamachary, P.T. Winnard Jr., V. Raman, L. Zheng, W.A. Mitzner, S. Sukumar and Semenza, all of Johns Hopkins.
Related websites Gregg Semenza:
www.hopkinsmedicine.org/ institute_cell_engineering/experts/ gregg_semenza.html Johns Hopkins Institute for Cell Engineering:
www.hopkinsmedicine.org/ institute_cell_engineering McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins:
www.hopkinsmedicine.org/ geneticmedicine ‘PNAS Early Edition’:
www.pnas.org/content/early/recent ‘Oncogene’:
www.nature.com/onc/index.html
November 14, 2011 • THE GAZETTE
Classifieds APARTMENTS/HOUSES FOR RENT
Bolton Hill, studio/1BR apt, huge windows, fp, full kitchen, deck, yd, priv prkng, huge BA w/double vanities, sep shower, soaking tub, can be partly furn’d, great for short-term residents. $950/mo. erasmocha@yahoo.com. Butchers Hill/Patterson Park, bright brick TH, 1BR + office, hdwd flrs, W/D, patio, nr park, conv to JHMI/JHH, refs req’d. $800/mo + utils + sec dep. 410-988-3137 or jhmirental@yahoo.com. Catonsville (40 Darrow Drive), 3BR, 1.5 house, freshly painted, crpt, hdwd flrs, W/D, garbage disposal, refrigerator, fin’d bsmt, deck, fenced backyd. Kendall Skirven, 410409-2743. Charles Village (33rd and University), tremendous 2BR apt, eat-in kitchen, laundry, enclosed porch. $1,500/mo. 410-383-2876.
M A R K E T P L A C E
gas heat and AC, fin’d bsmt, fenced yd, openair garage. 410-821-0058 or hlfreycorp@ yahoo.com. Sublet 1BR apt, Nov 19–30, quiet neighborhood, 15-min walk to Penn Station. $25/ day all-inclusive. 573-529-4358 (eve) or qhgb253@gmail.com. 2907 St Paul St, newly renov’d 1BR apt, 1st flr, hdwd flrs, new cabinets, safe and quiet neighborhood. $900/mo incl heat, water. murilo_silvia@hotmail.com.
HOUSES FOR SALE
Catonsville, fully renov’d 3BR, 2BA RH, hdwd flrs throughout, new windows, movein ready, affordable. $149,900. 443-8516514 or panfile@gmail.com.
Charles Village, apt avail in mid-January, walk to grocery/restaurants, rent incls utils, Internet. 585-729-1529.
Ellicott City, 4BR, 2BA+ colonial, quiet culde-sac location, great school district, perfect for young family. $550,000. 410-531-0321 or www.homesandland.com/Real_Estate/MD/ City/Ellicott_City/listingid/17510859.html.
Deep Creek Lake/Wisp, cozy 2BR cabin w/ full kitchen, call for wkly/wknd rentals. 410638-9417 or jzpics@yahoo.com (for pics).
Fells Point (300 blk S Durham St), 3 stories, just renov’d, big yd, 3 blks to JHH. $175,000. Dorothy, 410-419-3902.
Ellicott City, spacious 3BR, 2.5BA TH, kitchen/dining area, new windows, fin’d walkout bsmt, deck/patio, in Centennial high school zone. $1,875/mo. 410-979-9065 or rashmachaudhry@yahoo.com. Federal Hill, 2BR, 1BA rehab, 3 stories, water view, backyd, prkng, avail Dec 1. $1,900/mo (negotiable). 902-254-2040. Homewood area (295 W 31st St), 2BR TH, W/D, gas heat, deck, fenced yd, no pets/no smokers. $1,200/mo + utils. Val, 443-9948938. Parkside Drive, 1BR apt, 2nd flr, across from park, 10- to 15-min drive to JHH/JHU, pref nonsmoker, must pass rental application. $575/mo incl heat. Paula, 410-868-2815 or paulakowale@gmail.com. Patterson Park, 2BR, 2BA house, renov’d in 2007, walking distance to JHH/JHMI/ shuttle, W/D, unfin’d bsmt great for storage, good for roommates, dogs OK, 3 blks to park. 410-925-4497. Perry Hall, 1BR apt w/new appls, fresh paint, crpt, laundry rm, on dead-end street (no facing houses for privacy), great for senior living or mature tenant, easy access to 95/695. $1,000/mo. 443-882-5266 or christineepps0@msn.com. Roland Park, lg 1BR apt + dining rm, avail Dec 1. $1,100/mo incl heat, garage space, storage unit. mikesuse@comcast.net. Towson, 3BR rancher w/double BA, central
Room for Rent in home w/JHU Retiree Fully furn. w/Queen BD, 2 lg. dressers, closet, CD, TV, cable, equipped kitch. & laundry. $800/m, util./cable, each @ about $60. One time $450/sec. deposit req. Near JHU on Stonewood Rd.
443-904-7536, jackie.nunnally@gmail.com
Guilford, sun-filled, architect-renov’d 3BR, 3BA condo, huge terrace, study, eat-in gourmet kitchen, living rm, dining rm, family rm, 2 prkng spaces walk to Homewood campus/JHU shuttle stop. 410-366-8507 or jz1234@earthlink.net. Lutherville, 5BR, 2.5BA single-family splitlevel, on 0.42 acre lot, 2,498 sq ft, fp, hdwd flrs, orig owner, great public school district, nice neighborhood, good for kids, conv location. Tony, 410-804-3653. Owings Mills New Town, 2BR condo, nr metro, ready for immediate sale. www.4409silverbrook.info. Wyman Park, 2- to 3BR RH w/many upgrades, AC, modern furnace, enclosed porch, renov’d kitchen, move-in ready, walk to Homewood campus/shuttles, great neighborhood and neighbors. gaylemw@comcast.net. 3BR, 2.5BA TH, approx 11 mi to JHH, 6.5 mi to BWI. ktbsn@mac.com.
ROOMMATES WANTED
F nonsmoker wanted for lg furn’d BR and priv BA, high-speed Internet, nr JHH. $650/ mo + utils. myhome.2011@yahoo.com. Share all new refurbished TH w/medical students, 4BRs, 2 full BAs, CAC, W/D, dw, w/w crpt, 1-min walk to JHMI, 924 N Broadway. gretrieval@aol.com. Nonsmoker wanted for rm in new TH, walking distance to JHMI, no pets. 301-7174217 or jiez@jayzhang.com. Rm and BA in brand-new TH, walking distance to JHMC, pref nonsmoker/no pets. 410-456-1708 or xiaoningzhao1@gmail.com. M nonsmoker wanted to share 2BR, 3BA TH, 1 blk to JHMI campus, no pets, prkng provided. $700/mo. maimon.hubbi@gmail .com. Quiet prof’l wanted for BR in TH 10 mins
from Homewood, walk to MTA #11 bus, must be quiet, very clean, nonsmoker, love dogs, credit and background check req’d. $500/month-to-month incl cable, WiFi, heat/H20. jennyedd@gmail.com. Full furn’d rm avail, queen bed, 2 lg dressers, closet, CD, TV, cable, equipped kitchen, laundry rm, nr JHU on Stonewood Rd. $800/mo + sec dep ($450, one-time payment). jackie.nunnally@gmail.com. F grad or staff wanted for furn’d 3BR, 2BA house, short-term OK, avail mid-Dec. $550/ mo incl utils + sec dep. skbzok@verizon.net. F prof’l/grad student wanted to share 3BR, 1.5BA TH in Middle River, fp, walk-in closet, off bus line and train station. $600/mo incl utils, cable, Internet. marquitah2001@ yahoo.com. Share furn’d Fells Point house (N Collington Ave), w/2 F SPH students, new W/D, lg, renov’d kitchen, BR is well lit w/new blinds and crpt, access to rooftop deck w/garden, nr waterfront/JHMI/downtown by public transportation, possibility to renew lease. $600/ mo + utils. Jordan, 303-257-2929. Nonsmoker wanted for furn’d 700 sq ft BR in 3BR house in Cedonia owned by young F prof’l, bright, modern kitchen w/convection oven, walk-in closet, landscaped yd, lg deck, free prkng, public transportation to JHU, wireless Internet incl’d. $550/mo + utils. 410-493-2435 or aprede1@yahoo.com.
boston street | baltimore 410.534.3287 | langermanns.com
Beech Ave. adj. to JHU!
Studios - $595 - $630 1 BD Apts. - $710-740 2 BD from $795
on Hickory Avenue in Hampden!
2 BD units from $760 w/Balcony - $790!
Shown by appointment 410.764.7776 www.BrooksManagementCompany.com
SERVICES/ITEMS OFFERED OR WANTED
Need help writing letters? Experienced writer will write/edit all types of letters to your specs. emceea@gmail.com. LSAT tutor avail, current SAIS student (score 174, admitted to Georgetown, Penn, Cornell, Duke), flexible schedule, avail at Balto and DC campuses. $50/hr (negotiable). 240-600-7265. Peabody grad avail for babysitting and/ or piano lessons, exp’d teaching young children and babysitting experience incls infants. lauren88s@yahoo.com. Certified prof’l career coach avail to provide coaching to students/young prof’ls. 410-375-4042 or mmoLten1@yahoo.com. Spanish tutor wanted for toddler boy in Charles Village, 1-2 hrs/wk, pay negotiable, ideal for student wanting to make extra $. adam@usailc.com. Mobile auto detailing and power wash service. Jason, 443-421-3659. PT babysitter needed for Mt Washington–area family, must be responsible, excel driver w/own car, take kids to school AM, pick up late afternoon, lt cooking and housekeeping, free time during the day, free rm and board w/pay. 301-412-5588 or helenliucfa@gmail.com. Mature but relaxed prof’l looking for a rm, sublet, apt or share in the Charles Village vicinity. 347-403-2066 or josephmauricio@ yahoo.com.
CARS FOR SALE
’03 Toyota Camry LE, manual, beige, orig owner, meticulously maintained, loaded, extras, all records excel, Md insp’d, 99K mi. $7,400. valprice@verizon.net.
Thanksgiving pet food drive, donate a bag of dog/cat food. 410-870-2037 or www .thankfulpaws.org.
’89 Chevy 3/4 or 1-ton pickup truck, 4x4, rebuilt motor, new tires. $2,600. John, 443750-7750.
Looking for tutor to teach Dutch, an eager student seeks patient tutor; also want complete Nikon Multiphot macro camera system or parts. jtvriv@hotmail.com.
ITEMS FOR SALE
Responsible and loving pet-, baby- or housesitter avail, experienced w/special needs children and cats or dogs, refs avail. 202288-1311 or janyelle.thomas@gmail.com.
Entertainment center, $100; girl’s bike, $35; ladies blouses, skirts, hats, $3/ea; freezer, $25; and other items, buyer must haul. 443303-9047. Insignia sound system, $10; plates, glasses, cutlery; Franklin barstool, $12.50; Toshiba 25" stereo TV, not a flat-screen, $10; Medela breast pump and accessories, in excel cond, $125. 202-459-3169. Motorcycle gear: women’s leather jacket, size XS, lined, $125; women’s Milwaukee boots, size 7, $85; 12-volt battery charger, $55; all in excel cond. lisamwolf@comcast.net. Antique art deco furniture: 2 loveseats in eggplant velvet, $1,000/pair; 7-pc dining set, table, chairs, buffet, cabinet, gold oak w/red trim, $1,000. cgarvan@verizon.net. TVs (2): 46" Sony w/matching stand, $180; 24” flat-screen, $30; both in excel cond. Janejw_99@yahoo.com. New exterior French doors, music cassette tapes, fitness chair, 21" TV, 35mm cameras, silk flowers and vase, Asian decor pillows, office file units, men’s travel bag, dining rm set, full-length silver fox coat, BlackBerry Bold accessories, other misc items. 443-8242198 or saleschick2011@hotmail.com.
Horse boarding in Baltimore Co, beautiful trails in Greenspring and Worthington valleys from farm. $500/mo (stall board) and $250/mo (field board). 410-812-6716. Friday Night Swing Dance Club, open to public, great bands, no partners necessary. 410-663-0010 or www.fridaynightswing.com. Affordable and professional landscaper/certified horticulturist available to maintain existing gardens, also designing, planting or masonry; free consultations. David, 410683-7373 or grogan.family@hotmail.com. Tutor for all subjects/levels; remedial and gifted; also help w/college counseling, speech and essay writing, editing, proofreading. 410-337-9877 (after 8pm) or i1__@ hotmail.com. Licensed landscaper avail for lawn maintenance, yd cleanup; other services incl trash hauling, fall/winter leaf or snow removal. Taylor Landscaping LLC. 410-812-6090 or romilacapers@comcast.net. Hauling/junk removal, next-day service, free phone estimate, 15% discount for all Hopkins. John, 443-682-4875.
PLACING ADS Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines:
HICKORY HEIGHTS WYMAN COURT Just Renovated! A lovely hilltop setting
In the restaurant or in the boardroom let Chef Langermann handle the details.
11
• One ad per person per week. A new request must be submitted for each issue. • Ads are limited to 20 words, including phone, fax and e-mail.
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12 THE GAZETTE • November 14, 2011 N O V .
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Calendar COLLOQUIA Tues.,
Nov.
15,
4:15
p.m.
“Light-Triggered Reactions in Small Molecular Ions,” a Chemistry colloquium with Mathias Weber, University of Colorado. 233 Remsen. HW Wed.,
Nov.
16,
3:30
“Exploring the Diversity of Exoplanetary Atmospheres,” an STSci colloquium with Heather Knutson, Caltech. Bahcall Auditorium, Muller Bldg. HW
“Materialities of Violence, Violent Materialities: Artifacts, Documents, Monuments and Bodies in Turkish-Kurdish War Zone,” an Anthropology colloquium with Nazan Ustundag, Bogazici University. 404 Macaulay. HW
C O N FERE N C E S Fri., Nov. 18, 2:30 to 4:30 p.m.
“Health Systems for All: Expanding Horizons,” an International Health conference with keynote speaker Nelson Sewankambo, Makerere University, Uganda, and interactive session. (A cocktail reception will follow in E2030 SPH.) Open to faculty, staff and students only. E2014 SPH. EB DISCUSSIONS/ TALKS Tues.,
Nov.
15,
12:30
p.m.
“Politics, Foreign Aid and Basic Health Outcomes in Tanzania and Uganda, 1995–2009,” a SAIS International Development Program discussion with Kevin Croke, World Bank. To RSVP, call 202663-5943 or email mevange2@ jhu.edu. 200 Rome Bldg. SAIS “Populism in Africa: How the Opposition Won the 2011 Zambian Election,” a SAIS African Studies Program discussion with Nic Cheeseman, University of Oxford. For more information, call 202663-5676 or email itolber1@jhu .edu. 203 Rome Bldg. SAIS Tues., Nov. 15, 4:30 p.m.
Wed.,
Nov.
16,
12:30
p.m.
“Inclusion or Exclusion? Empowering the Next Generation,” a SAIS International Development Program discussion with Maya Ajmera, founder and president, Global Fund for Children and SAIS visiting scholar. To RSVP, call 202-870-6677 or
15,
5:30
Ross McElwee, an American independent documentary filmmaker (‘Sherman’s March’) who teaches at Harvard, leads a questionand-answer session after the screening of his film ‘Photographic Memory,’ which premiered at the 2011 Venice Film Festival. See Film/Video.
email developmentroundtable@ jhu.edu. 500 Bernstein-Offit Bldg. SAIS Wed.,
Nov.
16,
12:45
p.m.
“Challenges and Trends in Infrastructure Investing in Emerging Markets,” a SAIS Latin American Studies Program discussion with Benjamin Sessions, managing director, Global Environment Fund. (The speaker’s comments will be off the record.) For more information, call 202-663-5734 or jzurek1@jhu.edu. 517 Nitze Bldg. SAIS
“The Geopolitics of Hunger,” a SAIS Office of Development and Alumni Relations discussion with Jessica Adelman, Syngenta. A “Year of Agriculture” event. To RSVP, call 202-663-5636 or email saisag@ jhu.edu. A live webcast of the discussion will be accessible at www.sais-jhu.edu/pressroom/live .html. Kenney Auditorium, Nitze Bldg. SAIS Fri., Nov. 18, 12:30 p.m.
F I L M / V I D EO
Screening of Bernardo Bertolucci’s The Last Emperor, sponsored by East Asian Studies. 113 Greenhouse.
Thurs., Nov. 17, 7 p.m.
HW
Screening of Photographic Memory, by independent documentary filmmaker Ross McElwee. (See photo, this page.) After the screening, McElwee will talk about his work and lead a Q&A session. Sponsored by the JHU Film and Media Studies Program. 110 Hodson. HW
Fri., Nov. 18, 7 p.m.
G RA N D ROU N D S
“Maryland’s Youth Suicide Prevention Program: ‘A Caring Community Saves Lives,’ ” Public Health Practice grand rounds with Henry
Wed., Nov. 16, noon.
Westray Jr., Maryland Department of Health and Mental Hygiene, and Mary Cwik, SPH. Co-sponsored by Population, Family and Reproductive Health, the MidAtlantic Public Health Training Center and Maryland’s Department of Health and Mental Hygiene. W1214 SPH. EB I N FOR M A T I O N SESSIONS
“Remembering the Geniza: Making History From Fragments,” a Leonard and Helen R. Stulman Jewish Studies Program lecture by poet Peter Cole and essayist and biographer Adina Hoffman. Co-sponsored by the Baltimore Hebrew Congregation and the Walters Art Museum. Smokler Center for Jewish Life (Hillel). HW Wed., Nov. 16, 2 p.m. “Studies of Human Transposable Elements,” an Institute of Genetic Medicine lecture by John Moran, University of Michigan Medical School. Mountcastle Auditorium, PCTB. EB
Wed., Nov. 16, 4 p.m. “Dissonances in the Synagogue: The Theological Subconscious of Modern Music,” a Leonard and Helen R. Stulman Jewish Studies Program lecture by Ruth Ha-Cohen, Hebrew University, Jerusalem. Co-sponsored by Humanities. 208 Gilman. HW
The 2011 A.J. Goldman Lecture—“A Computationally Tractable Theory of Performance Analysis in Stochastic Systems” by Dimitris Bertsimas, MIT. Sponsored by Applied Mathematics and Statistics. 304 Whitehead. HW Thurs., Nov. 17, 1:30 p.m.
Tues., Nov. 15, 10 a.m. to 1 p.m. Fall supplier exhibit, spon-
sored by the JHU Core Store, with representatives from Agilent Technologies, Applied Biosystems, Bio-Rad, Cell Signaling, Fermentas, GE-Healthcare, Hyclone, Invitrogen, Mediatech, New England Biolabs, Perkin Elmer, Promega, QIAGEN, Quality Biological, Roche Applied Science and Sigma, displaying the latest literature and promotions. Representatives from the Genetic Resources Core Facility and Core Store will also be present. Turner Concourse. EB L E C T URE S
“Lexicography of the Jewish Aramaic Dialects From Late Antiquity,” a Leonard and Helen R. Stulman Jewish Studies Program lecture by Michael Sokoloff, Bar Ilan University, Tel Aviv. Co-sponsored by Near Eastern Studies. 130G Gilman. HW
Mon., Nov. 14, 3 p.m.
Center for Musculoskeletal Research Guest Lecture Series—“Molecular Mechanism of Muscle Hypertrophy,” by Karyn Esser, University of Kentucky. 5152 JHOC (Conference Room). EB
Thurs., Nov. 17, 4 p.m.
“On Making One’s Name as ‘Mother of the Gracchi,” a Program in Political and Moral Thought lecture by Matthew Roller, KSAS. Sponsored by Classics. 288 Gilman. HW Thurs., Nov. 17, 4:15 p.m.
“Kindred Spirits: Child and Text in German Realism,” a German and Romance Languages and Literatures lecture by Anette Schwarz, Cornell University. 479 Gilman.
Thurs., Nov. 17, 5:15 p.m.
HW
Tues., Nov. 15, 12:30 p.m. “The
NIH Grant Process: Application, Review and Funding,” a Center for Interdisciplinary Salivary Bioscience Research lecture by James Griffin, Shriver National Institute of Child Health and Human Development. Rooms 9 and 10, Pinkard Bldg. EB
Fri., Nov. 18, 5 p.m. The Gladys Callahan-Vocci-Justice Lecture— “Untangling the Net Jaguar of Teotihuacan” by Susan Toby Evans, Pennsylvania State University. Co-sponsored by History of Art and the Baltimore Society of the Archaeological Institute of America. 50 Gilman. HW
The Chesapeake Biological Labora-
Mon., Nov. 21, 1 p.m. “When Oral Torah Was Experienced as
Tues., Nov. 15, 4 p.m.
a Written Corpus,” a Leonard and Helen R. Stulman Jewish Studies Program lecture by Talya Fishman, University of Pennsylvania. Co-sponsored by History. Smokler Center for Jewish Life (Hillel). HW
p.m.
Tues., Nov. 15, 7 p.m.
“After Apollo: The Legacy of the Moon Landings,” a History of Science, Medicine and Technology colloquium with Roger Launius, National Air and Space Museum, Smithsonian Institution. 330 Gilman. HW
Tues., Nov. 22, 4 p.m.
Nov.
HW
Thurs., Nov. 17, 3 p.m.
“A Unifying Account of Inductive Reasoning,” a Cognitive Science colloquium with Charles Kemp, Carnegie Mellon University. 111 Krieger. HW
Tues.,
“Investors, Infrastructure and Interlocking Networks: Perspectives on the Structure of International Trade, ca. 2000–1700 BC,” a Near Eastern Studies lecture by Gojko Barjamovic, University of Copenhagen. 130G Gilman. HW Tues., Nov. 15, 5:45 p.m. “‘Tutta tonda di rilievo’: The Paradox of Relief and the Problem of Perspective,” a History of Art lecture by ACLS postdoctoral fellow Christopher Lakey, KSAS. 132 Gilman.
p.m.
Thurs., Nov. 17, 3:45 p.m.
tories Lecture—“Adventures in Mammalian Genetics” by Stephen Elledge, Harvard Medical School. Sponsored by Biological Chemistry. Auditorium (ground floor), WBSB. EB
Mon., Nov. 21, 5 p.m. The 2011 Provost’s Lecture Series— “Materials in Medicine: From Tools to Translational Tissue Engineering by Jennifer Elisseeff, SoM. Sponsored by the Office of the Provost. E2030 SPH. EB
MUSIC Fri., Nov. 18, 7:30 p.m., and Sun., Nov. 20, 3 p.m. Pea-
body Opera Theatre presents a new, fully staged production of Stravinsky’s The Rake’s Progress. (See story, p. 6.) $35 or $25 admission. To purchase tickets, go to www.lyricoperahouse.com or call 410-900-1150. Modell Performing Arts Center at the Lyric. Hopkins Symphony Orchestra Chamber Concert, performing works by Daugherty, Elgar, Copland and Bartok, with guest conductor Jason Love. No tickets or reservations needed; donations are welcome. Bunting-Meyerhoff Interfaith Center. HW
Sun., Nov. 20, 3 p.m.
REA D I N G S / B OO K TALKS Mon., Nov. 14, 12:30 to 2 p.m.
Eamonn Gearon will discuss his new book, The Sahara: A Cultural History. Sponsored by the SAIS African Studies Program. For more information, call 202-6635676 or email itolber1@jhu.edu. 500 Bernstein-Offit Bldg. SAIS Thurs., Nov. 17, 5:30 p.m.
Robert Guest, global business editor for The Economist, will discuss his new book, Borderless Economics: Chinese Sea Turtles, Indian Fridges and the New Fruits of Global Capitalism. Books will be available for purchase, and Guest will sign books at 5 p.m. To RSVP, call 202-663-5790 or email kkornell@ jhu.edu. Sponsored by the SAIS American Foreign Policy Program. Rome Auditorium. SAIS S E M I N AR S Mon., Nov. 14, noon. “Signaling for Sex in C. elegans,” a Bio-
Continued on page 8
(Events are free and Calendar open to the public Key except where indicated.) APL BRB CRB CSEB
Applied Physics Laboratory Broadway Research Building Cancer Research Building Computational Science and Engineering Building EB East Baltimore HW Homewood JHOC Johns Hopkins Outpatient Center KSAS Krieger School of Arts and Sciences NEB New Engineering Building PCTB Preclinical Teaching Building SAIS School of Advanced International Studies SoM School of Medicine SoN School of Nursing SPH School of Public Health WBSB Wood Basic Science Building WSE Whiting School of Engineering