The Gazette by The Johns Hopkins University

o ur 4 1 ST ye ar

C H URC H I LL S C H O LAR

S L OA N FEL L OW S

Covering Homewood, East Baltimore, Peabody,

Senior Hannah Joo is one of 14

Astrophysicist Brice Menard,

SAIS, APL and other campuses throughout the

students nationwide to receive

left, and Feilim Mac Gabhann

Baltimore-Washington area and abroad, since 1971.

prestigious scholarship, page 6

of BME receive awards, page 3

February 20, 2012

The newspaper of The Johns Hopkins University

Volume 41 No. 23

A R T S

C U R R I C U L U M

Jazz series readies for opening note

Training the Twitterati

By Greg Rienzi

The Gazette

Continued on page 5

will kirk / homewoodphoto.jhu.edu

omewood, get ready to feel the groove. This weekend sees the premiere of Jazz at the Johns Hopkins Club, a concert series that seeks to bring renowned, world-class musicians to the Baltimore area. The new series World-class kicks off on Saturday night with a musicians performance by the Jim Snidero Quarto perform tet at the Johns Hopkins Club, a in intimate 113-year-old institution and a fixture venue on the Homewood campus since the 1930s. The series, which is open to the public, is being made possible by a collaboration of Peabody’s Jazz Studies Department and the President’s Office. Gary Thomas, director and chair of Jazz Studies, met informally with President Ron Daniels last spring, and the two discussed the prospect of launching a jazz series at Homewood. Daniels, a jazz enthusiast, later suggested the use of the Johns Hopkins Club and agreed to have his office fund the endeavor, with Peabody providing artistic oversight and administrative support. The intent was to offer a state-ofthe-art, intimate platform for highquality jazz that could reach a broad audience. “Through this concert series, the Johns Hopkins Club has tied together Baltimore’s rich history of jazz music, the Peabody Institute’s world-class jazz program and the appreciation for live music felt across our campus and our city,” Daniels said. “I look forward to welcoming jazz enthusiasts to the Homewood campus.” Since its founding, the Johns Hopkins Club has served as a private club for university faculty, alumni, staff and friends of Johns Hopkins. The club serves lunch and dinner six days a week

Meg Chisolm, above, and Tabor Flickinger are leading a pilot study of a social media curriculum designed to promote medical humanism and professionalism. Volunteers in the eight-week Internal Medicine Clerkship will begin with blogs.

Psychiatrist Meg Chisolm champions social media for medical students By Greg Rienzi

The Gazette

argaret “Meg” Chisolm loves a good tweet. The owner of two Twitter accounts, Chisolm plugs in whenever time allows to share news or offer some thoughts. In a world awash in social media, the existence of another tweeter or blogger comes as no shock. What might surprise

some, however, is the fact that Chisolm is a psychiatrist, clinical researcher and academic who tweets about her work and profession. Chisolm, an assistant professor in Psychiatry and Behavioral Sciences at Johns Hopkins Bayview Medical Center, Continued on page 7

R E S E A R C H

Anti-HIV drug combos: Which work better and why By Audrey Huang

Johns Hopkins Medicine

sing a mathematical formula that carefully measures the degree to which HIV infection of immune system cells is stalled by antiretroviral therapy, AIDS experts at Johns Hopkins have

In Brief

Shuttle changes; SoM ‘Joining Forces’ with Michelle Obama; city police officers honored

calculated precisely how well dozens of such anti-HIV drugs work, alone or in any of 857 likely combinations, in suppressing the virus. Results of the team’s latest research reveal how some combinations work better than others at impeding viral replication and keeping the disease in check. “Our study results should help researchers and clinicians develop simpler treat-

ments, using either existing or new drugs, for people who are just starting therapy or people who have already tried and developed resistance to another combination,” said senior study investigator and infectious disease specialist Robert Siliciano, a professor in the Johns Hopkins University School Continued on page 8

10 Job Opportunities Greek Block Show; TB in Baltimore; ‘Talk 10 Notices 11 Classifieds to Me’ screening; ‘RefWorks’ workshop C A L E N D AR

2 20,2011 2012 2 THE THE GAZETTE GAZETTE •• February August 15,

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Changes coming to KeswickJHMI and JHMI shuttles

ome minor changes to the JHMI Shuttle and Keswick-JHMI Shuttle are about to go into effect. On Saturday and Sunday, Feb. 25 and Feb. 26, the JHMI stop for the Homewood-JHMI Shuttle will be temporarily relocated to the corner of Broadway and Monument streets; buses will not stop at Rutland and Washington streets during what has been described as a trial period. Effective Monday, Feb. 27, the JHMI stop for the Keswick-JHMI Shuttle will move from the corner of Wolfe and Monument streets to the corner of Washington and Monument streets, directly south of the JHMI Shuttle stop. In addition, the Keswick-JHMI Shuttle will stop at the Stieff Building, 810 Wyman Park Drive.

New institute to support first lady’s Joining Forces initiative

he Johns Hopkins University School of Medicine has joined the Association of American Medical Colleges and the American Association of Osteopathic Medicine to establish a Military and Veterans Health Institute as part of Michelle Obama’s Joining Forces initiative. The first lady’s initiative seeks to provide support for military service members and veterans in employment, education and health. The new institute’s mission will be to advance care for veterans and their families in psychological health, regenerative medicine and rehabilitation.

JHM Corporate Security chooses two officers of the year

he Johns Hopkins Medicine Corporate Security Office has chosen two Baltimore City policemen to receive its sixth annual Officer of the Year Award.

The recipients, Officer Exdol Williams of the Eastern District and Officer Robert Clark of the Southeast District, were recognized for their leadership ability, teamwork, dedication and exceptional enforcement activity to protect the East Baltimore community surrounding the hospital and School of Medicine.

Business prof writes on HR management, IT investments

dam Seth Litwin, an assistant professor at the Carey Business School with expertise in the areas of strategic human resources management and employment relations, has had his paper “Not Featherbedding but Feathering the Nest: Human Resource Management and Investments in Information Technology” accepted for publication in the tier one journal Industrial Relations, published by the University of California, Berkeley. Litwin’s research suggests that firms that are slow to adopt information technology find that a “conventional employment model” interferes with fully implementing new technologies, and it focuses attention on the facets of employment relations most conducive for innovation in the workplace.

JHH receives only Hospital of Choice Award in Maryland

he Johns Hopkins Hospital is the only medical center in Maryland to receive a Hospital of Choice Award from the American Alliance of Healthcare Providers. The AAHCP evaluates approximately 400 hospitals nationwide for the honor, which is based either on an extensive application process or by a secret review of the hospital’s public communications and staff interactions with patients and their families. JHH was one of 50 hospitals in 29 states and the District of Columbia to receive the award for the winter quarter.

JHU’s Ian Hsu named 2012 Gates Cambridge Scholar 866-498-6143 500 W. University Parkway Baltimore, MD 21210

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an Hsu, a third-year medical student at the Johns Hopkins University School of Medicine, is one of 40 students from the United States who have been awarded 2012 Gates Cambridge Scholarships. Hsu, who is from Troy, Mich., and received his undergraduate degree from the University of Michigan, will study for a master’s degree in social anthropology at the University of Cambridge, England. In October, the U.S. scholars will join the approximately 50 other students from around the world as the 12th contingent of Gates Scholars to matriculate at the University of Cambridge since the program began in 2001, the result of a $210 million gift

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from the Bill & Melinda Gates Foundation. The scholarship pays the full cost of pursuing a graduate degree at Cambridge, in any field of study, and the program is open to students from any country in the world except the United Kingdom. The other 2012 Gates Scholars will be named in the next several months, as academic calendars vary among the many countries from which applications are submitted. Hsu is the fifth student from Johns Hopkins to be awarded a Gates Cambridge Scholarship since the program began. For more about the Gates Cambridge Scholarships, go to news.admin.cam.ac.uk/news/ 2012/02/14/new-us-gates-scholars-selected.

Contributing Writers Applied Physics Laboratory Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg, Patrick Ercolano Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort

The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Communications, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date. Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 443275-2687 or gazellegrp@comcast.net.

February 20, 2012 • THE GAZETTE

K U D O S

Two from JHU awarded prestigious Sloan Research Fellowships By Lisa De Nike and Phil Sneiderman

Homewood

Brice Menard

Feilim Mac Gabhann

and his work has led to the detection of gravitational magnification by dark matter around galaxies, the discovery of tiny grains of dust in the intergalactic space and a better understanding of how light rays propagate throughout the universe. Menard is a joint member of the Institute for the Physics and Mathematics of the Universe at Tokyo University. He earned his doctorate from the Max Planck Institute for Astrophysics and the Institut d’Astrophysique de Paris and did postdoctoral work at the Institute for Advanced Study in Princeton, N.J. “Dr. Menard is pioneering the development of powerful new techniques to mine both the current and future sets of big astronomical data to reveal profound new insights into the universe,” said Daniel Reich, chair of the Physics and Astronomy Department at Johns Hopkins. “We are very pleased that the Sloan Foundation has recognized his accomplishments and potential for future impact in the field of astrophysics. We look forward to great things from Dr. Menard.” Mac Gabhann is an assistant professor of biomedical engineering and a core faculty member of the university’s Institute for Computational Medicine in the schools of Engineering and Medicine. “I was really delighted to receive this recognition,” he said. “I’m particularly happy because it reflects not just on the work that I’m doing but also on the great work being done by my lab members, both the students and the postdocs.” Mac Gabhann received a bachelor’s

degree in chemical engineering in 1997 from University College Dublin in his native Ireland and earned his doctorate in biomedical engineering from Johns Hopkins in 2006. He continued his research as a postdoctoral fellow at the Cardiovascular Research Center at the University of Virginia and joined the Johns Hopkins faculty in 2009. Mac Gabhann’s current research involves both computer models and biological lab studies. One of his goals is to use genetic and physiological data to differentiate subgroups of patients who respond differently to therapies. This approach could help personalize medical care so that individual patients receive the treatment that is most likely to yield favorable results. Earlier this year, Mac Gabhann was selected as the recipient of the American Physiological Society’s 2012 Arthur C. Guyton Award for Excellence in Integrative Physiology. “Feilim is a young star who is merging the fields of computational modeling and fundamental biology; he is breaking new ground in modeling growth factor networks and tissue morphogenesis,” said Elliot McVeigh,

JHU Engineers Without Borders to showcase humanitarian projects By Phil Sneiderman

Homewood

embers of the Johns Hopkins University chapter of Engineers Without Borders—who have launched humanitarian efforts in Ecuador, Guatemala and South Africa—will discuss and raise funds for their work at the group’s annual Dessert Reception and Project Showcase. The event will take place at 7 p.m. on Sunday, Feb. 26, in the Glass Pavilion on the Homewood campus. Attendees may participate in a raffle of items donated by local businesses and enjoy desserts donated by notable Baltimore bakeries. Admission is free, but contributions to support the group’s work are accepted. Now in its seventh year, the Johns Hopkins chapter of Engineers Without Borders has more than 50 student members representing a range of majors. The group works under the auspices of EWB-USA, a nonprofit humanitarian organization that seeks to meet the United Nations Millennium Development Goals through engineering and technological means. During the showcase and reception, David Mongan of the EWB-USA board of directors, and students and professional mentors from

PHILIP RINK JR.

homewoodphoto.jhu.edu

strophysicist Brice Menard and biomedical engineer Feilim Mac Gabhann of The Johns Hopkins University have won 2012 Sloan Research Fellowships, which seek to stimulate fundamental research by early-career scientists and scholars of outstanding promise by offering each a $50,000 grant, distributed over a two-year period. The two are among 126 young scientists and economists to receive the award this year in recognition of their potential to contribute to academic advancement. Since the Sloan Foundation began awarding fellowships in 1955, 38 recipients have gone on in their careers to win Nobel Prizes. In announcing the fellowships, Paul L. Joskow, president of the Alfred P. Sloan Foundation, said, “These outstanding men and women are responsible for some of the most exciting science being done today. The foundation is proud to support them during this pivotal stage of their careers.” Menard’s fellowship will further support his research on extragalactic astrophysics and cosmology; Mac Gabhann’s, his combined experimental-computational approach to developing new ways to treat major human diseases, including cancer, peripheral artery disease and HIV. “I am very honored to receive this award and appreciate the support of the Sloan Foundation for fundamental research,” said Menard, an assistant professor in the Henry A. Rowland Department of Physics and Astronomy in the Krieger School of Arts and Sciences. “This grant will help expand the activities of my research group into new directions.” Menard came to Johns Hopkins in 2010 from the Canadian Institute for Theoretical Astrophysics in Toronto, where he had worked as a senior research associate since 2006. A researcher in the field of extragalactic astrophysics and cosmology, he aims at achieving a better understanding of how dark matter is distributed in space and how galaxies form and evolve. To garner new insights, Menard analyzes large data sets with millions of astronomical objects,

each of the project teams, will present talks, exhibits and slides concerning three projects. In the Santa Rosa de Ayora community in Ecuador, EWB-JHU has been helping to construct a daycare center for young unsupervised children. In Chicorral, Guatemala, the closest source of potable water is located at the bottom of a 300-foot ravine. To make water collection easier for the women and children who are typically responsible for this task, EWB-JHU has designed a solar-powered pump. In KwaZulu-Natal, South Africa, where many residents are subsistence farmers, EWBJHU has been installing ram pump irrigation systems to provide easier access to water. The philosophy of the group is to improve living conditions and enrich lives, one community at a time. EWB programs range from constructing sustainable systems to enhancing the technical, managerial and entrepreneurial skills of community members. “EWB can require a big commitment, but traveling is a lot of fun because you get to interact with the locals and their culture,” said Pujan Desai, a biomedical engineering major who traveled to South Africa in August. “Not only do I get to use what I’ve been learning, but it’s also a great opportunity for me to work with professional engineers and help people.”

the Bessie Darling Massey Professor and director of Johns Hopkins’ Department of Biomedical Engineering. “Biology, math and computer science are becoming inexorably linked, and young faculty like Feilim are driving this change forward.” Raimond L. Winslow, director of the Institute for Computational Medicine, added, “Dr. Mac Gabhann’s work is a perfect example of the emerging discipline of computational medicine, in which experimentally based computational models of disease processes are used to obtain novel insights on disease mechanisms, and to reveal new therapies that are tailored to the needs of the individual. Biological systems, in both health and disease, are too complex to be understood without quantitative models that capture what we truly know about these systems and guide us through the highly complex landscape of biology. Dr. Mac Gabhann’s work is at the leading edge of computational medicine.”

Related websites Alfred P. Sloan Foundation:

www.sloan.org/fellowships Henry A. Rowland Department of Physics and Astronomy:

physics-astronomy.jhu.edu Feilim Mac Gabhann:

icm.jhu.edu/people/index .php?id=177 Department of Biomedical Engineering:

www.bme.jhu.edu Institute for Computational Medicine:

icm.jhu.edu

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4 20,2011 2012 4 THE THE GAZETTE GAZETTE •• February August 15,

Sequencing cancer mutations: There’s now an app for that JHU team’s free online software is faster, cheaper than other methods B y V a n e s s a W a s ta

Johns Hopkins Medicine

sing precise information about an individual’s genetic makeup is becoming increasingly routine for developing tailored treatments for breast, lung, colon and other cancers. But techniques used to identify meaningful gene mutations depend on analyzing sequences of both normal and mutant DNA in tumor samples, a process that can yield ambiguous results. Now, a team of Johns Hopkins researchers says it has developed an easyto-use online computer software application that can clear up any confusion faster and cheaper than other methods currently used to do the job. The application, called Pyromaker, is available free of charge at pyromaker .pathology.jhmi.edu, and a related tutorial will be posted there soon. The software generates simulated pyrograms, which are readouts from a gene-sequencing technique known as pyrosequencing. Most pyrograms correspond precisely to a person’s unique mutation or set of mutations, but some mutations can be more difficult to interpret than others, the Johns Hopkins researchers say.

“Pyromaker’s value is in rapidly sorting through each of several simulated pyrograms until there is a clear match with the actual tumor pyrogram,” said James R. Eshleman, a professor in the departments of Pathology and Oncology at the Johns Hopkins University School of Medicine. “Pyromaker enables us to do in minutes, essentially at no cost, what otherwise would take days of further, expensive tests.” Eshleman led the team that developed Pyromaker, the software code for which was written by Johns Hopkins pathology resident Matthew T. Olson. A report on the application, with demonstrations of Pyromaker’s ability to resolve sequencing ambiguities, was published online in the Journal of Molecular Diagnostics. Swedish researchers invented pyrosequencing in the mid-1990s as an alternative to the traditional method of gene sequencing. Pyrosequencing is an automated process in which solutions of the four DNAbuilding nucleotides or “bases” (G,C,T,A) are added, one at a time, to single strands of DNA from sampled cells in order to build up a complementary matching strand. A match with the next available base causes a chemical reaction with a special enzyme, which in turn emits a light pulse, resulting in a “peak” on the pyrogram, effectively indicating the next base in the DNA sequence. Pyrosequencing works on shorter stretches of DNA than does the traditional method, known as Sanger for its inventor, Frederick Sanger. Pyrosequencing is also more sensitive in registering the presence of mutant

DNA in a tumor sample, which is a mix of tumor and normal cells. That sensitivity makes it very useful for tumor sequencing, Eshleman says, because the mutant genes that drive a tumor’s abnormal growth typically are less prevalent in a tumor sample, compared with normal versions of those genes. Because a tumor pyrogram is an overlay of both healthy and mutant DNA, identifying the correct sequence may be difficult, and further studies to sort it all out can delay diagnosis and add significantly to costs, he says. To develop the software, Eshleman and his team first confirmed that simulated pyrograms generated by Pyromaker matched actual pyrograms of tumor DNA containing well-known, common cancer-driving mutations in the genes KRAS, BRAF, GNAS and p53. Then, they focused on the example of KRAS—an “oncogene” that helps drive many tumor types—to show that nearly all one- and two-base mutations in KRAS have distinguishable pyrograms. In a few cases, the researchers found that the pyrograms of two different mutations appear identical under certain sequencing conditions. With Pyromaker, they were able to show that pyrograms of two such mutations would become readily distinguishable if they were re-sequenced with a different order of added bases. Finally, the researchers applied Pyromaker to ambiguous KRAS pyrograms from two colorectal cancer patients, and, to resolve the ambiguities, compared the results with

tests using Sanger sequencing and other relatively time-consuming methods. The comparison showed that Pyromaker could resolve the ambiguities more quickly. Eshleman notes that Pyromaker also may be used with a new sequencing technology known as ion semiconductor sequencing, which detects a change in hydrogen ions instead of a light pulse. The software was written by Guoli Chen and Matthew T. Olson, both from Eshleman’s laboratory in the Department of Pathology at Johns Hopkins. Other scientists who contributed to the research are Alan O’Neill, Alexis Norris, Katie Beierl, Shuko Harada, Marija Debeljak, Keila Rivera-Roman, Samantha Finley, Amanda Stafford, Christopher David Gocke and Ming-Tseh Lin, all of Johns Hopkins. Contributions to funding the research came from the Sol Goldman Pancreatic Cancer Research Center, the Michael Rolfe Foundation, the Dick Knox Foundation and the National Institutes of Health.

Related websites Pyromaker:

pyromaker.pathology.jhmi.edu ‘Journal of Molecular Diagnostics’:

www.journals.elsevierhealth .com/periodicals/jmdi/article/ S1525-1578(11)00315-1/abstract

Animal study finds surprising clues to obesity-induced infertility B y E k at e r i n a P e s h e va

Johns Hopkins Medicine

nfertility is common among obese women, but the reasons remain poorly understood and few treatments exist. Now a team of Johns Hopkins Children’s Center scientists, conducting experiments in mice, has uncovered what it considers surprising evidence that insulin resistance, long considered a prime suspect, has little to do with infertility in women with type 2 diabetes, polycystic ovary syndrome or metabolic syndrome, all obesity-related conditions in which the body becomes desensitized to insulin and loses the ability to regulate blood sugar. In a report published online Nov.10 in the journal Diabetes, the Johns Hopkins scientists say that the real culprit appears to be insulin sensitivity in the ovaries and the pituitary. The Johns Hopkins team said that its findings show that these organs escape insulin resistance and, awash with high levels of circulating insulin common in obesity, develop abnormal cell signaling that disrupts ovulation and eventually leads to infertility. “Our findings suggest that the focus should shift from treating insulin resistance

in peripheral tissue to taming insulin sensitivity in the pituitary and ovaries,” said lead investigator Sheng Wu, of the Johns Hopkins Children’s Center. Scientists traditionally have treated obesity-induced infertility by lowering blood insulin to counter the effects of insulin resistance. A 2010 study by the same team discovered that the pituitary gland, insensitive to insulin in lean mice, became sensitive to elevated levels of insulin seen in human and

Related website Baltimore Diabetes Research and Training Center:

www.hopkinsmedicine.org/drtc/ index.html rodent obesity. By knocking out the insulin receptors in the pituitary glands of obese mice, the researchers were able to partially restore fertility, thus proving that abnormal insulin signaling in the pituitary was only part of the story. Senior investigator Andrew Wolfe, an endocrinologist at the Johns Hopkins Children’s Center, said, “In the original study, disrupting insulin signaling in the pituitary restored 50 percent of fertility in obese mice,

but the search was on for the accomplice. Our new findings point to the ovaries.” In the pituitary, faulty insulin signaling stimulates increased secretion of luteinizing hormone; in the ovary, it puts testosterone production into overdrive. Both disrupt ovulation, the researchers say. In the latest study, lean mice and mice made obese on a three-month high-fat diet received injections of progressively higher doses of insulin to mimic the effects of highcirculating insulin seen in obesity, diabetes and polycystic ovary syndrome. In lean mice, the ovaries and pituitaries were insensitive to the hormone at low-dose injections and responded only when injected with higher doses of insulin. The “trigger” doses corresponded to insulin levels typically seen in obesity. Obese mice with naturally elevated insulin levels exhibited high levels of insulin signaling in their pituitary and ovarian cells. When the obese mice were injected with insulin, their livers and muscles showed greatly reduced response to insulin—or insulin resistance. Their ovaries and pituitary glands, however, responded to insulin injections, confirming that in obese mice, these reproductive organs escape the insulin resistance seen in other organs. To determine insulin sensitivity, the researchers focused on two signaling pro-

teins, IRS-1 and IRS-2, regulators of cellinsulin communication involved in the development of insulin resistance in liver and muscle tissue. The scientists hypothesized that in the pituitary and ovaries, these messenger proteins would remain dormant under normal insulin levels but would get activated once exposed to high levels of insulin. Indeed, the researchers found that the pituitary glands of obese mice showed higher IRS-2 signaling activity compared with those of lean mice, while the ovaries of obese mice had higher signaling activity in both IRS-1 and IRS-2 proteins compared with those of lean mice. In a follow-up study now under way, the Johns Hopkins team is trying to determine whether knocking out the insulin receptors in both the ovaries and the pituitary would fully restore fertility in obese mice with high insulin levels. Other investigators on the study were Sara Divall and Fred Wondisford, both of Johns Hopkins. The research was funded by the Endocrine Fellow Foundation, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the Baltimore Diabetes Research and Training Center, which is supported by the National Institute for Diabetes and Digestive and Kidney Diseases.

Elevated glucose associated with undetected heart damage By Tim Parsons

Bloomberg School of Public Health

new study led by researchers at the Johns Hopkins Bloomberg School of Public Health suggests that hyperglycemia, or high blood sugar, injures the heart, even in patients without a history of heart disease or diabetes. Researchers found that elevated levels of glycated hemoglobin, or HbA1c, a marker for chronic hyperglycemia and diabetes, were associated with minute levels of the protein troponin T, or cTnT, a blood marker for heart damage. The high-sensitivity test they used detected levels of cTnT 10-fold

lower than those found in patients diagnosed with a heart attack. The findings, which are published in the Jan. 31 issue of the Journal of the American College of Cardiology, suggest that hyperglycemia may be related to cardiac damage independent of atherosclerosis. “Hyperglycemia and diabetes are known to be associated with an increased risk for heart attack and coronary disease, and our study sheds some light on what may be happening,” said Elizabeth Selvin, senior author of the study and an associate professor in the Bloomberg School’s Department of Epidemiology. “Our results suggest that chronically elevated glucose levels may contribute to heart damage.” For the study, the researchers followed

9,662 participants from the Atherosclerosis Risk in Communities study. None of the participants had coronary heart disease or history of heart failure. Higher levels of HbA1c were associated in a graded fashion with elevated levels of high-sensitivity cTnT. This relationship was present at HbA1c levels even below the threshold used to diagnose diabetes. Using conventional tests, troponin T can be detected in 0.7 percent of the population and is associated with heart attacks and death. With the high-sensitivity cTnT test, low levels of troponin were found in 66 percent of the study population. Jonathan Rubin, who was lead author of the study while studying at the Bloomberg School, said, “Our study hints at other

potential pathways by which diabetes and elevated glucose are associated with heart disease. Mainly, glucose might not only be related to increased atherosclerosis, but potentially elevated glucose levels may directly damage cardiac muscle,” said Rubin, now a general internal medicine fellow at the Johns Hopkins School of Medicine. Additional authors of the study are Kunihiro Matsushita and Josef Coresh, both of the Bloomberg School; and Christine M. Ballantyne and Ron Hoogeveen, of the Baylor College of Medicine. The research was supported by grants from the National Heart, Lung and Blood Institute and the National Institute of Diabetes and Digestive and Kidney Diseases.

February 20, 2012 • THE GAZETTE

Jazz Continued from page 1 and hosts more than 60 special events a year, including wine tastings, lectures, theater nights and holiday galas. Since 1937, the club’s home has been a three-story Georgian-design structure located near Nichols House on the northwest side of the Homewood campus. Cem Baraz, general manager of the Johns Hopkins Club, said that the club has hosted musical performances before but never a formal music series. “We are thrilled to host this series and bring jazz to the Johns Hopkins community and beyond,” Baraz said. “We hope to make this an exciting concert venue that exposes more faculty, staff, students and alumni to the club.” The series’ spring 2012 schedule will feature four artists, one each month, beginning with two sets on Feb. 25 by the Jim Snidero Quartet. Snidero, an alto saxophonist, has been an innovator in the jazz world for decades. In addition to his solo career, Snidero has played with Frank Sinatra, nine-time Grammy winner Eddie Palmieri and the Mingus Big Band. His current quartet features Paul Bollenback on guitar, Paul

Jim Snidero opens the series with his quartet on Saturday night.

Gill on bass and McClenty Hunter on drums. The shows will take place in the club’s lounge, which seats 70. Tickets will be sold separately for each set, with performances beginning at 8:30 p.m. and 10 p.m. Bar service will be available 30 minutes before and during the performance; no food will be served.

Upcoming performances in the series include Peabody alum Russell Kirk and The Path on March 31, the John Scofield Trio on April 21 and the Roy Haynes Fountain of Youth Band on May 26. (Haynes will receive the Peabody Medal and speak at the school’s commencement ceremony on May 24.) Thomas—a renowned saxophonist who has played in the bands of Miles Davis, Herbie Hancock and Jack DeJohnette—said that he set out to select high-caliber talent for the series, such as drummer Roy Haynes, an icon in the genre. Snidero, guitarist John Scofield and bassist Ed Howard from the Roy Haynes band will teach master classes at Peabody during their visits to Baltimore, said Ian Sims, the academic coordinator for the Jazz Studies Department and a member of the Peabody Preparatory faculty. “In addition to attracting prominent artists for performance, there is a clear educational benefit to the series,” said Sims, a tenor saxophone and clarinet player in the Peabody Jazz Ensemble. “Students in Baltimore will be able to learn from some great names in jazz, an opportunity that might have otherwise been difficult to arrange.” Tickets for the Jim Snidero Quartet are $35 for general admission and $18 for Johns Hopkins students. Tickets can be purchased online at www.peabodyjazz.org/ hopkinsclub. G

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hough an estimated 26.7 million Americans age 50 and older have hearing loss, only about one in seven uses a hearing aid, according to a new study led by Johns Hopkins researchers. The finding adds clarity to less-rigorous estimates by device manufacturers and dem-

Related websites Otolarygology–Head and Neck Surgery at Johns Hopkins:

www.hopkinsmedicine.org/ otolaryngology Frank Lin:

www.hopkinsmedicine.org/ otolaryngology/our_team/faculty/ lin_frank.html Wade Chien:

www.hopkinsmedicine.org/ otolaryngology/our_team/faculty/ chien.html onstrates how widespread undertreatment of hearing loss is in the United States, the study investigators say. “Understanding current rates of hearing loss treatment is important, as evidence is beginning to surface that hearing loss is

associated with poorer cognitive functioning and the risk of dementia,” said study senior investigator Frank Lin, an otologist and epidemiologist. “Previous studies that have attempted to estimate hearing aid use have relied on industry marketing data or focused on specific groups that don’t represent a true sample of the United States population,” added Lin, an assistant professor in the Johns Hopkins University School of Medicine and Johns Hopkins Bloomberg School of Public Health. To address the data gap, Lin and Wade Chien, also an assistant professor at Johns Hopkins, used data from the 1999–2006 cycles of the National Health and Nutrition Examination Survey, a research program that has periodically gathered health information from thousands of Americans since 1971. During those cycles, participants answered questions about whether they used a hearing aid and had had their hearing tested. The researchers’ new findings, published in the Archives of Internal Medicine online Feb. 13, showed that only about one in seven individuals age 50 or older (14 percent) use hearing aids; use rose with age, ranging from 4.3 percent in individuals 50 to 59 years old to 22.1 percent in those 80 and older. Overall, another 23 million could possibly benefit from using the devices, Lin said. Lin says that many people with hearing loss likely avoid the use of hearing aids, in part because health insurance often does not cover the costs, and because people do not receive the needed rehabilitative training to learn how to integrate the devices into their daily lives. But another major reason, he says, is that people often consider hearing loss inevitable and of minor concern. “There’s still a perception among the public and many medical professionals that

Info session set for Carey School ‘global immersion’ course

he Johns Hopkins Carey Business School will hold an information session on Thursday, Feb. 23, for a “global immersion” course the school will offer in the spring in Baltimore and Istanbul. The session will take place via conference call and webinar from noon to 1 p.m. Open to Johns Hopkins graduate students interested in learning how business competitiveness is developed on an international scale, the two-credit course will consist of three sessions in Baltimore (April 19 and 26, and May 3) and a one-week residency in

Istanbul (May 27 to June 2). Mark Kennedy, an executive in residence at the school and a former three-term congressman from Minnesota, will serve as instructor. The class size will be limited to 22 students. To join the information session by phone, call 410-955-4009, access code 246800. On the Web, go to connect.johnshopkins.edu/ turkey. For more information, contact Emmanuel Opati, senior project associate for Carey’s Global MBA program, at emmanuel.opati@ jhu.edu.

hearing loss is an inconsequential part of the aging process and you can’t do anything about it,” Lin said. “We want to turn that idea around.” Lin and his colleagues currently are leading a study to investigate the effects of hearing aids and cochlear implants on the social, memory and thinking abilities of older adults. Funding support for this study was provided by the National Institutes of Health.

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6 20,2011 2012 6 THE THE GAZETTE GAZETTE •• February August 15, R E C O G N I T I O N

Johns Hopkins senior Hannah Joo wins Churchill Scholarship B y A m y L u n d ay

Homewood

JUSTIN R. PORTER

Hannah Joo is one of 14 students nationwide to have been named a Churchill Scholar.

“I feel honored to have been selected as a Churchill Scholar, and I am very excited to go to Cambridge and work with Dr. Roberts,” Joo said. “My application would not have been possible without the opportunities and support of my professors, my research mentors and Dr. Kelly Barry in the scholarships office.” Joo has been involved in research at Johns Hopkins as the winner of one of the university’s Woodrow Wilson Fellowships, which grant undergraduates up to $10,000 to pur-

will kirk / homewoodphoto.jhu.edu

annah Joo, a Johns Hopkins University senior from Redmond, Wash., has been selected as a Churchill Scholar by the Winston Churchill Foundation of the United States. The Churchill Scholarship is awarded to 14 students nationwide who have demonstrated a capacity to contribute to the advancement of knowledge in the sciences, engineering or mathematics by completing original, creative work at an advanced level. As a 2012 Churchill Scholar, Joo will spend the next academic year pursuing a master of philosophy degree at the University of Cambridge in England. The foundation will provide full tuition and fees as well as a stipend for living expenses and travel. Joo, 21, has already completed the required course work for her bachelor’s degree in neuroscience from the Zanvyl Krieger School of Arts and Sciences, which she will receive in May before beginning her studies at Cambridge. She will conduct research in the lab of Angela Roberts, a professor in the Department of Physiology, Development and Neuroscience, studying emotion regulation in marmosets as a model for human emotion processing. This research is expected to contribute to the development of targeted therapies for anxiety and depressive disorders.

‘Federal Foodies’ explores farm-to-table living in the early 1800s in Baltimore.

‘Taking Root in the City’ B y H e a t h e r E ga n S t a l f o r t

JHU Museums and Libraries

he university’s Homewood Museum, in partnership with the Center for a Livable Future at the Johns Hopkins Bloomberg School of Public Health, will present a conversation on urban agriculture and local sustainability at 2 p.m. on Sunday, Feb. 26, in Room 101 of the Mattin Center’s F. Ross Jones Building on the Homewood campus. The concept of urban farming has gained traction nationally over the past decade, and several farms have sprouted on empty plots across Baltimore in recent years. The panelists will discuss urban farming initiatives in Baltimore and how they can positively impact employment, community development, the environment and food access in the city. Joining the discussion, titled Urban Agriculture: Taking Root in the City, will be Denzell Mitchell Jr., founder of Five Seeds Farm and Apiary; Billy Thomas, a member of the Baltimore Free Farm collective; Katie Dix, coordinator of the Community Greening Resource Network at the Parks and People

Foundation; Maya Kosok, a community fellow at the Open Society Institute–Baltimore, who is working to create an urban farming cooperative; and Abby Cocke, an environmental planner in the Baltimore Office of Sustainability. The conversation will be moderated by Amanda Behrens, research program manager at the Center for a Livable Future. The program is presented in conjunction with Homewood Museum’s current exhibition, Federal Foodies: From Farm to Table in Early Baltimore, on view through Sunday, April 29. Built in 1801 by Charles Carroll Jr., Homewood once stood on a 130-acre working farm, which later became the Johns Hopkins campus. The exhibition, organized by students in last fall’s Introduction to Material Culture course offered by the Krieger School’s Museums and Society Program, explores farm-to-table living in the early 1800s, from farming and gardening practices to how foods were preserved, prepared and presented. Admission to the panel discussion is free and open to the public. Guests are invited to visit the Federal Foodies exhibition before or after the program. For more information, go to www.museums .jhu.edu or call 410-516-5589.

sue an independent research project over the course of their undergraduate careers. Since May 2009, she has spent all academic breaks working in the lab of Dennis Dacey, a professor at the University of Washington in Seattle, where she investigated the anatomy of retinal cell types and their respective roles in the early stages of visual processing. Joo is the first author of a paper describing a novel retinal cell type that was published in Visual Neuroscience in January 2011, and she is co-author of a manuscript in preparation in the Dacey lab. She has presented her research on the visual system at the Johns Hopkins Neuroscience Research Symposium and at five international conferences. “Hannah is highly intelligent and can work hard, fast and efficiently and is never distracted,” Dacey wrote in his letter of recommendation for the scholarship. “[She] is someone who continually seeks out the biggest and toughest challenges; she is a tenacious goal setter who loves to compete and is destined for leadership in her chosen field.” At Johns Hopkins, Joo also has been working since September 2010 in the lab of Samer Hattar, an associate professor of biology in the Krieger School of Arts and Sciences. Her research in the Hattar lab has focused on the anatomy of a specific class of retinal cell that is critical for setting the body’s circadian rhythm. She is co-author of one manuscript in preparation that is the

result of a collaborative project between the Dacey and Hattar labs. “[Hannah has] the passion and drive for science,” Hattar wrote in his letter of recommendation for the scholarship. “In one sentence: She is the total package. She represents the students that make me proud to be a professor at The Johns Hopkins University.” During her sophomore year, Joo worked in the lab of Marshall Hussain Shuler, an assistant professor in the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins School of Medicine, investigating neurological reward systems. In fall 2011, she participated in the Johns Hopkins Pre-Professional Advising Office’s clinical tutorial program under the supervision of Kathryn Wagner, director of the Kennedy Krieger Institute’s Center for Genetic Muscle Disorders. Joo is a member of the Johns Hopkins Neuroscience Honor Society, Nu Rho Psi, and a mentor for underclassmen in the Woodrow Wilson program. In 2011, she was awarded a Goldwater Scholarship, which recognizes and supports outstanding achievement in science, math or engineering. As part of her Woodrow Wilson project, Joo is writing a series of essays mentored by William Evans, a senior lecturer in the Johns Hopkins Expository Writing Program. She has had three articles published in a Johns Hopkins literary magazine, Thoroughfare. After the conclusion of her Churchill Scholarship, Joo expects to enroll in an MD/PhD program. She plans to complete her medical specialization in neurology and earn a doctorate in neuroscience. She is the daughter of Leslie R. Schenck and Tae H. Joo, and she graduated from Inglemoor High School in Kenmore, Wash. Johns Hopkins students interested in applying for nationally competitive scholarships should contact Kelly Barry, director of Fellowships and Scholarships, at kbarry@jhu.edu or visit the scholarships website at www.jhu.edu/scholarships. General information sessions will take place on Thursday, March 8, and Wednesday, March 28. There is a special session on the Churchill Scholarship planned for Thursday, April 19.

Related website The Winston Churchill Foundation of the United States:

www.winstonchurchillfoundation .org

Using risk-adjustment strategies to navigate road to health care reform By Tim Parsons

Bloomberg School of Public Health

paper authored by Jonathan Weiner and colleagues from the Johns Hopkins Bloomberg School of Public Health, appearing in the Feb. 8 issue of Health Affairs, describes why health reform could lead to favorable or adverse risk selection across health plans. The article reviews provisions within the Affordable Care Act legislation and discusses key risk-adjustment implementation issues for states establishing health insurance exchanges. The paper also presents results from a simulation using data from 5 million insured people to show how risk-adjusted transfer payments will be essential to help minimize selection bias across participating health plans. “When setting payment rates for the private health plans that will insure consumers in each state’s health insurance exchanges, the differences in the medical needs of each enrollee group must be accounted for,” said Weiner, a professor in the Bloomberg School’s Department of Health Policy and

Management. “If we don’t allocate more funds to plans enrolling sicker persons, the health insurance exchanges—and possibly health reform itself—could fail, as some health plans might go under, while others could experience large windfalls.” States have a very tight timeline in which to form health insurance exchanges that will serve as the clearinghouses where millions of Americans will get access to health insurance, often with a federal subsidy. Much attention has been focused on getting the new exchanges up and running, but the premise of this article is that in the very near future, when the exchanges are functional, the strategies and tools they will use to pay the plans and transfer resources from plans with healthier enrollees to those with sicker ones will rapidly become a top issue. The analysis in this article applied the Johns Hopkins ACG System, a diagnosisbased risk-adjustment methodology that is widely used in more than 15 nations and is being made available to state exchanges as a public service of the university. (For more information on the methodology, go to www.acg.jhsph.edu.)

February 20, 2012 • THE GAZETTE

New technique dissolves blood clots in brain, lowers stroke risk B y S t e pha n i e D e s m o n

Johns Hopkins Medicine

ohns Hopkins neurologists report success with a new means of getting rid of potentially lethal blood clots in the brain safely, without cutting through easily damaged brain tissue or removing large pieces of skull. The minimally invasive treatment, they report, increased by 10 to 15 percent the number of patients with intracerebral hemorrhage, who could function independently six months after the procedure. At the International Stroke Conference held Jan. 31 to Feb. 2 in New Orleans, the researchers presented their findings from 93 patients, ages 18 to 80, who randomly got either the new treatment or standard-of-care “supportive” therapy that essentially gives clots a chance to dissolve on their own. The study was coordinated by Johns Hopkins and the surgical review centers at the universities of Cincinnati and Chicago. All

Twitterati Continued from page 1 said that she is one of a growing number of medical professionals who, despite the present-day climate of strict patient privacy regulations and oversight, see the benefits of using social media to supplement their work and interact with colleagues, patients and the general public. Chisolm connects with others through her Twitter accounts “whole_patients,” intended to demystify psychiatry and psychotherapy for patients and doctors, and “psychpearls,” which is targeted to learners interested in “clinical pearls” about psychiatry. To help expose future medical professionals to the benefits and potential pitfalls of social media use, Chisolm and Tabor Flickinger, a clinical education fellow, have set forth on the design of a social media curriculum for students at the School of Medicine. Ultimately, the two plan to design, pilot, study and implement a curriculum that uses social media to promote medical humanism and professionalism. As part of this effort, Chisolm and Flickinger proposed an educational research project to be conducted in the Internal Medicine Clerkship course for third-year medical students. In December, Chisolm and Flickinger received an Osler Center for Clinical Excellence small grant award to run the pilot study, which will be conducted during the first and second quarters of the 2012–13 academic year, which starts in August. The Osler Center was established in 2002 within the Division of General Internal Medicine to train physicians in the basic elements of a sound doctor-patient relationship. The format of the pilot study will be a voluntary online addition to clinical activities during the eight-week Internal Medicine Clerkship. One group of students will participate in a blog where they can write about and discuss their clinical experiences. Another group will serve as a comparison cohort; they will be studied but will not participate in the blog. The blog will be private and monitored by Chisolm and Flickinger, who is principal investigator on the Osler Center grant. No other faculty or students will have access. Chisolm said that the blog will be a space for reflection. The students can talk about powerful clinical experiences, which might encourage introspection and sharing by other students and faculty, and form a support network of helping relationships. “They can talk about their experience

93 patients were diagnosed with intracerebral hemorrhage, or ICH, a particularly lethal or debilitating form of stroke long considered surgically untreatable under most circumstances. “The last untreatable form of stroke may well have a treatment,” says study leader Daniel F. Hanley, a professor of neurology at the Johns Hopkins University School of Medicine. “If a larger study proves our findings correct, we may substantially reduce the burden of strokes for patients and their families by increasing the number of people who can be independent again after suffering a stroke.” Often caused by uncontrolled high blood pressure, ICH is a bleed in the brain that causes a clot to form. The clot builds up pressure and leaches inflammatory chemicals that can cause irreversible brain damage, often leading to death or extreme disability. The standard of care for ICH patients is general supportive care, usually in a hospital’s intensive care unit; only 10 percent undergo the more invasive and risky craniotomy surgery, which involves removing a portion of the skull and making incisions through healthy brain tissue to reach and remove the clot. Roughly 50 percent of people who suffer an intracerebral hemorrhage die from it. In the United States, 15 percent of stroke

patients have ICH, a rate that translates to roughly 30,000 to 50,000 individuals—more often than not, Asians, Hispanics, AfricanAmericans, the elderly and those who lack access to medical care. The more common form of stroke is ischemic stroke, which occurs when an artery supplying blood to the brain is blocked. Surgeons performed the minimally invasive procedure by drilling a dime-sized hole in each patient’s skull close to the clot location. Using a CT scan that Hanley likens to “GPS for the brain,” they guided the catheter through the hole and directly into the clot. The catheter was then used to drip small doses of the clot-busting drug t-PA into the clot for a couple of days, shrinking the clots roughly 20 percent per day. Those patients who underwent supportive therapy saw their clots shrink by about 5 percent per day. A major advantage of the minimally invasive surgery is that it busts the clot without the potentially injurious side effects associated with craniotomy, Hanley says. The minimally invasive approach also was found to be as safe as general supportive therapy, which can involve intense blood pressure control, artificial ventilation, drugs to control swelling and watchful waiting for the clot to dissipate on its own. For the new study, patients were treated

at more than two dozen sites throughout the United States, Canada and Europe, by staff neurologists and surgeons. Hanley says it’s a bonus that patients don’t need specialized equipment to have the procedure done. “More extensive surgery probably helps get rid of the clot but injures the brain,” he says. “This ‘minimalist approach’ probably does just as much to clear the clot, while apparently protecting the brain.” The research is supported by the National Institute of Neurological Disorders and Stroke.

with real patients, the process of learning,” she said. “Along the way, they will learn the parameters of what they should or should not talk about in this kind of public forum.” Chisolm and Flickinger will meet with the students at the beginning and end of the pilot study. The remainder of the time, the investigators will interact with the students remotely, as the students will be in separate clinical settings: Bayview Medical Center, The Johns Hopkins Hospital and Sinai Hospital. The investigators aim to use the blogbased educational intervention to facilitate the personal growth of medical students and promote the qualities of humanism and professionalism. Flickinger, who herself has a Twitter account and a blog on literature and medicine called “Tea with Dr. Tabor,” said that the blog will allow the students to think about their development, professional challenges and new identities as doctors. “They can reflect on encounters and situations that might have bothered them, or talk about successes,” she said. “This experience will teach them skills of reflective writing, and to think critically about issues of professionalism. It’s also a proactive way to get them to use social media in a professional way before they are released into the wild, so to speak. And do so in a protected way.” Chisolm said that the blog won’t be censored, but she and Flickinger will notify the students if they cross a professional line, or come close to it. Social media, she said, clearly pose special challenges and risks. In 2010, a physician was fired from Westerly Hospital in Rhode Island after posting information about a trauma patient on Facebook. According to the Rhode Island Board of Medical Licensure and Discipline’s 2011 ruling on the matter, the physician did not mention the patient’s name in the post but included enough information to allow others to identify the patient. At the University of Chicago, a frenzy was set off in 2007 by a YouTube video posted by first-year medical students. The video, filmed for use in a university-sponsored talent show, was a rap parody of an anatomy lab experience set to music that depicted the students lying in body bags, dissecting corpses, dancing with plastic skeletons and studying in class. Students asked for and received permission to post the video, which became a viral hit. Later, however, the video came under scrutiny for its content—and how it represented the school—and the university took the post down while it developed more specific guidelines for such social media use. The video was later re-posted with a disclaimer.

Chisolm said that she and Flickinger will use these cases to discuss the risks and benefits of social media and what the guidelines should be. In future studies, students may be permitted to use other social media, such as Twitter and YouTube. “But for now we want to stick to a blog as the medium and see how that goes,” Flickinger said. “It’s easy to set privacy controls, and the students can enter longer and more substantial posts than they can on Twitter or Facebook.” Ultimately, the investigators hope to implement the curriculum and study its impact within the medical learning community’s longitudinal curriculum. Future external funding will be sought for Phase II of the project. Innovative social media curricula are currently being piloted at medical schools and centers throughout the United States, including at Brown University, University

of Chicago, George Washington University and the Cleveland Clinic. No such curriculum currently exists at Johns Hopkins. Chisolm said that the impact of a social media curriculum on medical students’ personal growth, humanism and professionalism has never been reported, making this research project highly innovative. Social media tools—such as blogs, Twitter, YouTube videos and Facebook—have the potential to transform academic environments and engage teachers and learners in new ways, Chisolm said. They also offer a way for medical professionals from across the world to connect with each other. The use of social media, especially prevalent among younger generations and growing rapidly, she said, presents an opportunity to enhance medical education. “Social media is here to stay, and ubiquitous in our society,” she said. “I think we need to study the benefits and teach students about the challenges.” G

Related websites Daniel Hanley:

www.hopkinsmedicine.org/ doctors/results/directory/ profile/0001943/ daniel-hanley?firstLetter=H Neurology and Neurosurgery at Johns Hopkins:

www.hopkinsmedicine.org/ neurology_neurosurgery Trial report:

mistietrial.com/default.aspx

DAVID CHISHAM

CT-guided catheters carry drug to shrink clots, Johns Hopkins–led study shows

Emilie and Elizabeth Kim, who are home-schooled in Montgomery County, learn about chemical reactions by making raisins dance in a Johns Hopkins MCC lab.

Home-schoolers’ field trip

ifty home-schooled students grades pre-K to seven—all part of the LEAP Co-op in Montgomery County—got a hands-on science lesson on Feb. 6, thanks to representatives from the JHU Center for Biotechnology Education. After a brief primer on lab safety from Audrey Moshfeghian, CBE senior lab coordinator at Johns Hopkins’ Montgomery County Campus, the pre-K through second-grade students learned

about chemical reactions by making bouncy balls and getting raisins to dance. They also got a lesson on how well—or, in some cases, how poorly—they washed their hands. After the younger kids were done, the third- to seventh-grade students got their opportunity to learn about chemical reactions and DNA … and to practice their CSI skills through three activities: making silly putty, creating DNA necklaces and undertaking a bloodtyping exercise. —Robin Ferrier

8 20,2011 2012 8 THE THE GAZETTE GAZETTE •• February August 15,

Cheers Cheers is a monthly listing of honors and awards received by faculty, staff and students plus recent appointments and promotions. Contributions must be submitted in writing and be accompanied by a phone number. APPLIED PHYSICS LABORATORY Danielle Hilliard , a project manager in

the Air and Missile Defense Department, has received the Black Engineer of the Year Community Service Award. Hilliard was honored for her volunteer efforts in the community, including work with students in Howard and Prince George’s counties and with the local chapters of the Mathematics, Engineering, Science Achievement program. Hilliard, who joined APL in 2001, commits up to 12 hours a week to judging public school science, technology, engineering and math competitions and to helping with activities such as MentorNet, Project Lead the Way and Girl Power, an APLsponsored event that familiarizes middle and high school girls with STEM careers. P a t r i c k N e w e l l , supervisor of the Space Department’s Space Weather Science and Applications Section, has been elected a fellow of the American Geophysical Union. Newell specializes in space weather, primarily studying the aurora by using images and particle measurements from satellites. His nomination specifically lauded his 1996 discovery that sunlight suppresses strong aurora, but his discoveries also include the first rigorous criteria for identification of the particle cusp, the first map of precipitation according to magnetospheric source region, the first composite imaging of the plasma sheet and finding a nearly universal solar wind–magnetosphere coupling function. Newell joined APL in 1985 and has written or co-written about 230 refereed journal publications. Edward Tunstel , a robotics engineer in the Space Department, has been named a fellow of the Institute of Electrical and Electronics Engineers in recognition of his work on planetary missions. Tunstel came to APL in 2007 from NASA’s Jet Propulsion Laboratory, where he developed autono-

Anti-HIV Continued from page 1 of Medicine and a Howard Hughes Medical Institute investigator. Siliciano and colleagues constructed the measurement tool, called the instantaneous inhibitory potential, or IIP, in the laboratory several years ago by analyzing the shape of drug dose–response curves in human immune system cells infected with HIV. They found that the curves’ steepness reflects the extent to which small increases in the amount of a drug can further suppress attempts by the virus to bounce back, reproduce and spread. Researchers say that their latest findings, published in the journal Nature Medicine online Feb. 19, along with other recent studies, provide valuable information to physicians about the potential strength of different combination drug therapies, and can help in streamlining and tailoring so-called highly active antiretroviral therapy, or HAART, to the fewest possible drugs needed. Several hundred thousand of the more than 1 million Americans living with HIV disease are currently using HAART to fight the disease. Among the latest study’s key findings was that the most-potent drug combos included the drugs efavirenz (a non-nucleoside reverse transcriptase inhibitor) and darunavir (a protease inhibitor). According to the Johns Hopkins team’s calculations, the drug mix suppressed viral replication by more than a trillion times, enough to prevent infection of every single lymphocyte, or immune system cell, of which there are a trillion in the body. The least-powerful drug was found to be one of the oldest anti-HIV medica-

F O R

T H E

mous control and navigation algorithms, software and systems for robotics research and spaceflight projects, including the Mars Exploration Rovers, on which he served as a flight systems engineer for autonomous rover navigation and was the mobility and robotic arm subsystem lead for surface mission operations. BAYVIEW MEDICAL CENTER Phillip Dennis has been named direc-

R E C O R D

Stuzin is a partner at Brown Advisory, where he is responsible for managing the firm’s large-cap growth portfolios and is also the lead manager for the Brown Advisory Growth Equity Fund. Previously, Stuzin was vice president and portfolio manager at J.P. Morgan & Co. in Los Angeles. He is a graduate of Columbia University and received his MBA from the Columbia Business School.

tor of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Bayview and director of the Department of Oncology. Dennis says he will expand and integrate oncology care across departments to provide better access to cancer screening, diagnosis and treatment. He also will lead all lung cancer treatment efforts within the center’s Upper Aerodigestive Cancer Program, including the creation of a Center of Excellence in Thoracic Oncology. It will include clinical care, translation/clinical research and teaching. Dennis will recruit new faculty, and integrate and align current faculty in the Kimmel Cancer Center on the East Baltimore campus and at Johns Hopkins Bayview. Dennis was previously a tenured senior investigator in medical oncology at the National Cancer Institute. Anita Langford , vice president for care management services, has received this year’s William J. McCarthy Award from the Bayview board of trustees. The award recognizes Langford’s ability to go beyond expected standards of service and to skillfully juggle the operational oversight of the Johns Hopkins Bayview Care Center as well as hospital services, which include pharmacy, care management, social work, admissions, rehabilitation, patient relations, pastoral care and volunteer services. Langford came to Bayview (then Baltimore City Hospitals) in 1981 as the assistant director of Psychiatric Nursing. In 1985, she was named director of Nursing for the Mason F. Lord Chronic Hospital and Nursing Facility, which is now the Bayview Care Center. She then became administrator for the Care Center and senior director of long-term care. She has been a medical center vice president since 2004. K e n n e t h M . S t u z i n has been appointed to Bayview’s board of trustees.

KRIEGER SCHOOL OF ARTS AND SCIENCES Richard Kagan , the Arthur Oncken Love-

tions, d4T, or stavudine (a nucleoside analog reverse transcriptase inhibitor), which had the power to suppress viral replication by less than 10 times if used on its own (although, Siliciano points out, it works much better when taken in combination with other drugs). Siliciano says that the most widely used combination, a single pill known as Atripla, consisting of tenofovir disoproxil fumarate (a nucleotide analog reverse transcriptase inhibitor), emtricitabine (also a nucleoside

to achieve near total suppression,” Siliciano said. Less than 7 million of the 34 million people worldwide infected with HIV are taking antiretroviral therapy, he notes. The Johns Hopkins team based its new calculations on five years of analyzing just how antiretroviral drugs hinder key steps in HIV’s life cycle, preventing it from replicating and infecting other immune system cells. Scientists have for decades focused on multiple drugs targeting different enzymes that are key to the viral life cycle, thinking that multiple barriers along the chain could best halt replication. Although the strategy worked, scientists had, until now, no theory to explain why some drug combinations worked well and others did not. Indeed, they point out, one of the newest classes of anti-HIV medications, so-called integrase inhibitors, did not work well as single drug treatments in laboratory experiments but were highly effective in people when combined with other drugs. Siliciano says that as a result of the Johns Hopkins team’s latest research and another of its recent findings, published in Science Translational Medicine in July, experts can finally demonstrate how different drug combinations disrupt and halt viral replication. Researchers found that the steepest curves occurred when the drug targeted a stage in HIV’s life cycle in which many copies of viral enzymes were needed. Citing protease inhibitors as an example, Siliciano says that several copies of protease enzyme are needed to cleave the virus into hundreds of working parts before HIV can infect a new immune system cell. He goes on to say that “a level of inter-enzyme cooperation” is happening, specific to each stage of HIV replication. “Our research shows that drugs like protease inhibitors really work like an on-off switch,” Siliciano said. “Above a certain

Related websites Robert Siliciano:

www.hopkinsmedicine.org/ pharmacology_molecular_ sciences/faculty/bios/siliciano.html ‘Nature Medicine’:

www.nature.com/nm/index.html ‘Science Translational Medicine’:

stm.sciencemag.org/content/3/91/ 91ra63.full.pdf analog reverse transcriptase inhibitor) and efavirenz, was able to reduce viral replication to as few as one in a billion. Siliciano points out, however, that any drug combination that suppresses viral replication to the degree that out of every 100,000 lymphocytes exposed to the drugs, only one lymphocyte is likely to be infected (for five 10-fold reductions) is sufficient to keep the disease in check, so long as people take their medication as prescribed. “This means that overall access to antiHIV medications could also improve as we develop simpler combinations of fewer drugs

Graduate Performance Diploma recipients Meng Su and Yameng Wang) took part in WQXR’s China in New York Festival, held Jan. 23 to 29. Pianist Lior Willinger , a sophomore in Yong Hi Moon’s studio, won both the first prize and audience prize in the Camerata Virtuosi New Jersey Young Artists International Competition on Jan. 7. He will perform Prokofiev’s Third Concerto with the ensemble on April 14 at New York’s Symphony Space. SAIS

joy Professor of History in the Department of History, has received the 2011 Premio de Investigacion Humanistica Real Sociedad Menendez Pelayo for his book Clio and the Crown: The Politics of History in Medieval and Early Modern Spain, published in Spanish as Los Cronistas y la Corona: La Politica de la Historia en la Espana Medieval y Moderna. In accepting this honor in Spain in May, Kagan will present a lecture, to be published, before an audience of scholars and notables.

Students K y l e B u r g e s s , E l i z a b e t h Hegedus-Berthold and Erik Leikin

MULTIDISCIPLINARY

assistant dean for human research protection and director of the Human Research Protection Program in the Office of Human Subjects Research. A graduate of Stanford Law School and Seattle University’s master of public administration program, Carrithers joined Johns Hopkins in 2002. For the past nine years she has overseen implementation of the institutional review board electronic submission system, which allows researchers to prepare, submit and track their human subjects research applications online. She succeeds Barbara Starklauf, who retired in December. Todd Dorman , senior associate dean for education coordination, associate dean for continuing medical education, and professor and vice chair for critical care in the Department of Anesthesiology and Critical Care Medicine, has been appointed to a threeyear term on the board of directors of the Accreditation Council for Continuing Medical Education, the nation’s main accrediting body for CME. Dorman will serve on the ACCME’s Decision Committee, which

Three Johns Hopkins faculty members are among the men and women chosen as 2012’s Influential Marylanders by The Daily Record, Baltimore’s legal and business newspaper. Those cited as having made significant impacts in their fields and as leaders in the state are pediatric neurosurgeon Benjamin Carson and Cornelia Trimble of the Johns Hopkins Center for Cervical Dysplasia, both in the Health Care category, and astrophysicist Adam Riess , in the Technology category. PEABODY INSTITUTE

The United States Marine Chamber Orchestra—known as The President’s Own— recently performed Southern Comforts by Music Theory faculty member Joel Puckett , with Staff Sgt. Sheng-Tsung Wang, a Peabody violin alumnus, as soloist. The performance was held Jan. 29 in the Rachel M. Schlesinger Concert Hall and Arts Center at Northern Virginia Community College, in Alexandria, Va.  Distinguished Visiting Artist Shenyang and the Beijing Guitar Duo (Peabody

participated in the Pace/ICLN International Criminal Court Moot Competition round for the Americas and the Caribbean from Feb. 10 to 12 at Pace University School of Law in New York. Leikin won the Best Brief Defense award and Hegedus-Berthold took third place for Best Oralist.

SCHOOL OF MEDICINE Judith Carrithers has been appointed

Continued on page 9

concentration, these drugs completely turn off viral replication. When you have only one copy of a viral enzyme needed in any key part of HIV’s life cycle, a little more drug won’t give you a lot more suppression; but when you have more than one copy of enzyme needed for viral replication, then the dose-response curve for the drug will be a lot steeper, and a little more drug will completely shut off viral replication, which is what we want. “It’s gratifying,” he added, “to finally have a consistent metric for evaluating HAART medications that offers reliable information on how well they work in stopping HIV replication, and which also gives us a baseline target for suppression at less than one in 100,000 immune cells becoming infected in the presence of any drug combination.” The Johns Hopkins inhibition index was first developed to compare the level of viral inhibition from different drugs in different classes and to show how they could be graded. Having measured the different potencies of many drugs, Siliciano conducted his next set of lab experiments to focus on the explanation behind different strengths of viral inhibition. The scientists measured the changes in the dose-response curves, plotting the results on graphs and comparing the sloping curves for each drug or combination of drugs. Funding for this study, conducted solely at Johns Hopkins, was provided by the Howard Hughes Medical Institute and the National Institute of Allergy and Infectious Diseases. In addition to Siliciano, Johns Hopkins researchers who took part were lead investigator Benjamin Jilek, Melissa Zarr, Maame Sampah, Alireza Rabi, Cynthia Bullen, Jun Lai and Lin Shen. Currently, more than 34 million people in the world are living with HIV, including an estimated 1,178,000 in the United States and 23,000 in the state of Maryland. G

February 20, 2012 • THE GAZETTE

Cheers Continued from page 8 reviews and provides final recommendations on accreditation status nationwide. Jeanne Keruly , assistant professor of medicine and director of the Ryan White HIV/AIDS Clinical Services program, has been named vice chair of the Greater Baltimore HIV Health Services Planning Council. Keruly, who also is operations manager of Johns Hopkins’ HIV Clinical Outcomes program, has been a member of the planning council since 1998. Joanna Pearson , a 2010 graduate of the School of Medicine and a second-year resident in the Department of Psychiatry and Behavioral Sciences, has received the

Milestones The following staff members are retiring or celebrating an anniversary with the university in February 2012. The information is compiled by the Office of Work, Life and Engagement, 443-997-7000.

WHITING SCHOOL OF ENGINEERING Seth Guikema , an assistant professor in

Five faculty members from Johns Hopkins are among the 14 nurse researchers who will be inducted into Sigma Theta Tau International’s International Researcher Hall of Fame. The prestigious award from nursing’s honor society recognizes “STTI nurse researchers from around the world who have achieved significant and sustained national

and/or international recognition for their work and whose research has impacted the profession and the people it serves.” The Johns Hopkins recipients, who will be honored at STTI’s 23rd International Nursing Research Congress, to be held this summer in Brisbane, Australia, are Jerilyn K. Allen , associate dean for research and the M. Adelaide Nutting Professor in the Department of Acute and Chronic Care; Deborah Gross , the Leonard and Helen R. Stulman Professor in Mental Health and Psychiatric Nursing; P a m e l a J e f f r i e s , associate dean for academic affairs and a professor in Health Systems and Outcomes; Miyong Kim , director of the Center for Cardiovascular Health in Vulnerable Populations, professor and chair of the Department of Health Systems and Outcomes; and Marie Nolan, professor and chair of the Department of Acute and Chronic Care.

Ma rti n , Rose, Human Nutrition

Ku t ch i n s , Kimberly, Institute of Genetic

Shaw , Roosevelt, Oncology

2012 Donald Justice Poetry Prize from West Chester University for her first collection of poetry, Oldest Mortal Myth. It will be published in June. T h o m a s Q u i n n , professor of medicine and director of the Center for Global Health, was chosen to deliver the Benjamin Keane Lecture at the Weill Cornell Medical Center in New York last October, and will be given the University of Notre Dame’s Distinguished Alumnus Award this May. SCHOOL OF NURSING

S a a m s , Joy, Epidemiology S te wa rt , Sean, Center for

Communication Programs Wa g ne r , Erika, Center for Communication Programs Wa g one r , Annette, Epidemiology Ya nc e y , Darell, Facilities HOMEWOOD STUDENT AFFAIRS

ACADEMIC AND CULTURAL CENTERS

30 years of service P l i ska , Cecilia, Business Management

35 years of service Smith , Patricia, Johns Hopkins University Press

KRIEGER SCHOOL OF ARTS AND SCIENCES

15 years of service Amir , Elaine, Montgomery County Campus Bro ds ky , Simeon, Center for Talented Youth Wh ite , Galen, III, Center for Talented Youth 10 years of service Kim , Young, Jhpiego P ero u tka , Paul, Johns Hopkins University Press 5 years of service Bun ke r , Edward, Jhpiego Fedo r , Randi, Family Academic

Programs Mb a h , Gladys, Bioethics Institute BLOOMBERG SCHOOL OF PUBLIC HEALTH

20 years of service Go rlin , Dina, Population, Family and Reproductive Health Ja me s , Tara, Population, Family and Reproductive Health Sewell , Mary, Health Policy and Management 15 years of service Busch , Florence, Center for Immunization Research and Vaccine Sciences Go klis h , Novalene, Center for American Indian Health Gresh , Kathy, Academic Affairs 10 years of service Atkinson , Christine, Population, Family and Reproductive Health C a lvin , Katherine, Financial Operations Ja k litsch , Wendy, Academic Affairs Rich ar ds , Cecelia, Center for American Indian Health Ta b a ha , Ladonna, Center for American Indian Health 5 years of service

15 years of service Wonne l l , Steven, Physics and Astronomy 5 years of service B a ke r , Daniel, Advanced Academic

Programs

S c ha p pe l l e , Kenneth, Advanced

Academic Programs

PEABODY

10 years of service J e f f e rson , Wesley, Jr., Facilities SCHOOL OF EDUCATION

10 years of service B a ke r , Jerrell, Center for Social Organization of Schools SCHOOL OF MEDICINE

Retiree B ra sw e l l , Wilhelmena, 11 years of service,

Pathology

40 years of service Va n K e u r en , Nancy, Clinical

Immunology, Bayview

35 years of service H u l l , James, Institute for Basic Biomedical

Sciences Wol l e tt , Rosalie, Oncology 30 years of service

F ou nta i n , Michele, Oncology

25 years of service D a v i l a , Earnest, Anesthesiology and Critical Care Medicine Gra u l , Susan, Surgery Gre e n , Veronica, Center for Functional Anatomy La roc c a , Ann, Oncology Ma rks , Cheryl, Infectious Diseases Ma ta nosk i , Dennis, Surgery P e te rs , Natalie, Biological Chemistry S e a l , Stella, Welch Medical Library Wa tki ns , Lee, Jr., Institute of Genetic Medicine

Den t , Anna, Biostatistics

20 years of service

Ja mison , Charles, Academic Affairs

E sp i na s , Joseph, Orthopaedics

Leflar , James, Jr., Support Services

Gre e nba u m , Milton, Ophthalmology

Medicine

St r z eg o w s k i , Tracey, Neurosurgery

15 years of service B o l t o n , Stephen, Pathology Di l l a r d , Jennifer, Pathology Do h en y , Kimberly, Institute of Genetic

Medicine L a d s o n , Kim, Pulmonary Ph i l l i p s , Stephanie, Continuing Medical Education St u a r t , Sylvia, Physiology 10 years of service A s h en , Marie, Cardiology B y r n e , Kathleen, Pediatrics C el i o , Shawn, Human Resources C z ech , Holly, Neurosurgery F er n a l d , Tiffany, Otolaryngology Ha r r i s , Tina, Facilities Ha r t z , Patricia, Institute of Genetic Medicine Ken n ed y , Leslie, Clinical Practice Association L o u d en , Susan, Oncology O w o ey e , Ibitayo, Oncology R i ch a r d s o n , Jeffory, Pathology R o g er s , Charlene, Urology T h o m p s o n , Theodore, Facilities U p d i k e , Marcia, Emergency Medicine Wa l k er , Rhea, Pathology W h eel er , Latina, Oncology 5 years of service B a rci k o w s k i , Terry, General Internal

Medicine B ei er l , Katie, Pathology B r o w n , Deborah, Pathology C l a i b o r n e , Torran, Psychiatry C o o k , Katie, Infectious Diseases C o p p er , Reagan, Anesthesiology and Critical Care Medicine E d el s t ei n , William, Radiology Ho l b r o o k , Teri, Pediatrics Jo n es , Geraldine, Neurology Jo n es , Terry, Johns Hopkins Technology Transfer Ko r t o , Kau, Anesthesiology and Critical Care Medicine L i n , Lu, Anesthesiology and Critical Care Medicine M a n f u s o , Lisa, Dermatology M a r s o v a , Ekaterina, General Internal Medicine M i n k en , Heidi, Fund for Johns Hopkins Medicine M o o r e , Shanell, Surgery M u s e , Angelina, Neurosurgery N o l a n , Carol, Clinical Practice Association N o r t o n , Katie, Fund for Johns Hopkins Medicine O a k j o n es - B u r g es s , Karen, Pulmonary O ’ Do n n el l , Ryan, Neurology Pu r t el l , Katrina, Oncology

the Department of Geography and Environmental Engineering, is the recipient of an NSF Faculty Early Career Development award. Guikema’s award will support his efforts to provide an approach for assessing the economic, environmental and social sustainability and reliability of interdependent power and water systems, particularly in areas susceptible to natural hazards such as hurricanes and earthquakes. His research will include the development of indicators for measuring trends in these areas as well as the creation of new computational frameworks for modeling these systems. Ultimately, Guikema’s work could enable improved and more-cost-effective methods for assessing and managing aging infrastructure systems in the United States.

Shel for d , Tameka, Institute of Genetic

Medicine

Toney , Pamela, Neurology Toom ey , Mai P., Orthopaedics

SCHOOL OF NURSING

25 years of service M i l es , Olivia, Registrar’s Office SHERIDAN LIBRARIES/ JHU MUSEUMS

10 years of service Bec ht el , Eric, Sheridan Libraries UNIVERSITY ADMINISTRATION

40 years of service L ea , Frank, Supply Chain Shared Services 35 years of service Sp i nk , William, Jr., Facilities

25 years of service Gi l l , Lloyd, Office of Chief, Enterprise

Technology Services

P et er s , Susan, Human Resources

20 years of service M i t c hel l , Clifton, Supply Chain Shared Services Wi l l i am s , James, Facilities 15 years of service H i l l , Douglas, Development and Alumni Relations Ing l i s , Richard, Controller 10 years of service Ar nekl ev , Eric, Controller Bel l - Fr azi er , Miriam, Office of Vice Provost for Research D em bec k , Brian, Johns Hopkins Real Estate Thac ker , Richard, Jr., Facilities 5 years of service Ad am es , Ivan, Development and

Alumni Relations Cox , Harold, Development and Alumni Relations Johns on , Stacey, Administrative and Financial Services WHITING SCHOOL OF ENGINEERING

Retiree Abel , Candance, 21 years of service, Electrical and Computer Engineering 40 years of service Ri c har d s on , Joyce, Engineering for

Professionals

15 years of service Al bi nak , Anne, Business Office

5 years of service Tum i nel l o , Mark, Engineering for

Professionals

10 20,2011 2012 10 THE THE GAZETTE GAZETTE •• February August 15, H U M A N

B U L L E T I N

R E S O U R C E S

Notices

Hot Jobs Listed below are some of the university’s newest openings for indemand jobs that we most urgently need to fill. In addition to considering these opportunities, candidates are invited to search a complete listing of openings and apply for positions online at jobs.jhu.edu.

Annual Public Health Career Fair will be held from 10 a.m. to 3 p.m. on Friday, March 2, in the Bloomberg School of Public Health’s Feinstone Hall and Gallery. Sponsored by the Career Services Office, the fair is an opportunity for undergraduate and graduate students to meet with representa-

Office of Human Resources Wyman Park Building, Suite W600 410-516-7196 Homewood Campus Safety and Security is seeking candidates for several openings. For detailed job descriptions and to apply, go to jobs.jhu.edu. Continued from page 12

Campus Police Officer Security Officer II Technical Support Analyst

“A Genome-Wide SiRNA Screen for Global Understanding of MHC Class II Antigen Presentation,” an Immunology Training Program seminar with Jacques Neefjes, the Netherlands Cancer Institute. Tilghman Auditorium, Turner Concourse. EB

Fri., Feb. 24, 1 p.m.

School of Medicine Office of Human Resources 98 N. Broadway, Suite 300 410-955-2990

Medical Office Coordinator/Certified Medicine Assistant Insurance Specialist Pro Fee Coordinator Medical Assistant Medical Assistant/Patient Service Coordinator Medical Assistant/Patient Service Coordinator

Schools of Public Health and Nursing Office of Human Resources 2021 E. Monument St. 410-955-3006 The Bloomberg School of Public Health is offering several opportunities for individuals seeking positions in the field of finance and who posses strong analytical, organizational and communication skills. For detailed job descriptions and to apply, go to jobs.jhu.edu. 51455 50865 50752 50430

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2 7

“Investigating DXP Synthase: Implications for Drug Design,” a Pharmacology and Molecular Sciences thesis defense seminar with Leighanne Brammer, SoM. 303 WBSB.

ble Diseases,” an International Health seminar with An Pan, Harvard School of Public Health. W2030 SPH. EB The David Bodian Seminar—“The Integrative Nature of Scene Representation” with Soojin Park, KSAS. Sponsored by the Krieger Mind/ Brain Institute. 338 Krieger. HW

Mon., Feb. 27, 4 p.m.

Fri., Feb. 24, 3:30 p.m.

The School of Medicine is seeking experienced applicants for several medical office positions. For detailed job descriptions and to apply, go to jobs.jhu.edu. 50298 50765 48902 51281 51343 50711

2 0

Calendar

Homewood

47257 51241 49953

tives from around the country to discuss employment opportunities, consultancies and internships, and to obtain career information about the corporate, government and nonprofit sectors. Among the employers scheduled to attend are Abt Associates, International Medical Corps, The Lewin Group, Northrop Grumman and the Maryland Department of Health and Mental Hygiene. No registration is required. For more information, go to www.jhsph .edu/careerfair or call 410-955-3034.

Public Health Career Fair — The 28th

F E B .

B O A R D

Financial Analyst Financial Manager Research Service Analyst Sponsored Projects Specialist

EB Mon., Feb. 27, 9 a.m. “Persistent Viral Infections and Clinical Outcomes in Community-Dwelling Older Adults,” a Graduate Training Program in Clinical Investigation thesis defense seminar with George Wang. 901 Hampton House. EB

“DNA Interstrand Crosslinks as a Driver of Mammalian Aging,” a Biochemistry and Molecular Biology seminar with Laura Niedernhofer, University of Pittsburgh. W1020 SPH. EB

Mon., Feb. 27, noon.

“Personalized Therapy for Advanced Non-Small Cell Lung Cancer: Lessons Learned From the Battle Trials,” a FAMRI Center of Excellence seminar with Roy Herbst, Smilow Cancer Hospital at Yale–New Haven. Owens Auditorium, CRB. EB

Mon., Feb. 27, 12:15 p.m.

“Pushing the Limits of Biological Fluorescence Microscopy,” a Carnegie Institution Embryology seminar with Eric Betzig, Janelia Farms. Rose Auditorium, 3520 San Martin Drive. HW

SPECIAL EVENTS

“A Step Into History: The Annual Greek Block Show,” featuring stepping JHU fraternity and sorority members. A Black History Month event, sponsored by the Office of Multicultural Affairs. Glass Pavilion, Levering. HW

Thurs., Feb. 23, 8 to 10 p.m.

Sun., Feb. 26, 2 to 4 p.m. “Urban Agriculture: Taking Root in the City,” a multidisciplinary panel discussion on the intersection of urban farming and community organizing in Baltimore. Panelists include Abby Cocke, Baltimore Office of Sustainability; Katie Dix, Parks and People Foundation; Denzel Mitchell, Five Seeds Farm; Billy Thomas, Baltimore Free Farm; and Maya Kosok, fellow, the Open Society Institute. (See story, p. 6.) Sponsored by Johns Hopkins University Museums, in conjunction with Homewood Museum’s winter focus exhibition, Federal Foodies: From Farm to Table in Early Baltimore. SDS Room, Mattin Center. HW

Mon., Feb. 27, 12:15 p.m.

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria.

Mon., Feb. 27, 3 p.m. “Nutrition and Prevention of Global Noncommunica-

W OR K S H O P S Wed., Feb. 22, 4:30 p.m. “RefWorks,” an MSE Library workshop on the online citation manager, which helps users organize citations and create easy, quick bibliographies. Electronic Resource Center, M-Level, MSE Library. HW

Chlorhexidine umbilical cord care can save newborn lives By Tim Parsons

Bloomberg School of Public Health

leansing a newborn’s umbilical cord with chlorhexidine can reduce his risk of infection and death during the first weeks of life by as much as 20 percent, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. The study, conducted in rural Bangladesh in partnership with ICDDR,B and Bangladeshi NGO Shimantik, and funded by the United States Agency for International Development and Save the Children’s Saving Newborn Lives program, is the latest in a series of studies showing that umbilical cord cleansing with chlorhexidine can save lives. The new findings were published online Feb. 8 by The Lancet.

For the study, Johns Hopkins researchers and colleagues in Bangladesh enrolled more than 29,000 newborns in a randomized trial to determine the effectiveness of single or seven-day cleansing with 4 percent chlorhexidine as compared to the standard dry cord care. According to the study, infants who received a single cleansing with chlorhexidine were 20 percent less likely to die compared with infants who received the standard dry cord care. Reductions in mortality were not statistically significant among the seven-day cleansing group compared to dry care, but the infants did have fewer signs of cord infection. “Chlorhexidine cord cleansing is a simple, safe, effective and inexpensive intervention. Large-scale implementation of this intervention with universal coverage has the potential to avert an estimated half

a million neonatal deaths per year,” said Abdullah Baqui, senior author and principal investigator of the study and a professor in the Bloomberg School’s Department of International Health. An early study conducted by Johns Hopkins researchers in Nepal showed that cleansing the umbilical cord with chlorhexidine for seven of the first 10 days of life resulted in a 24 percent decrease in mortality compared to children who received dry cord care. A separate study by researchers from Aga Khan University in Pakistan, which also appears in the current issue of The Lancet, found that cord cleansing with chlorhexidine reduced infant mortality by 38 percent and infections by 42 percent. “Giving birth and a child’s first week are risky times for a mother and her newborn,”

said Rajiv Shah, administrator of USAID. “These studies provide evidence of a simple, low-cost technology that can prevent illness and death for the most vulnerable children. USAID is committed to transforming research into better results and access to lifesaving interventions.” Neonatal deaths account for more than 40 percent of the estimated 8.8 million deaths of children under the age of 5 each year worldwide. In high-mortality settings, more than half of those neonate deaths are the result of serious infection. Authors of the study, in addition to Baqui, are Shams El Arifeen, Luke C. Mullany, Rasheduzzaman Shah, Ishtiaq Mannan, Syed M. Rahman, M. Radwanur R. Talukder, Nazma Begum, Ahmed Al-Kabir, Gary L. Darmstadt, Mathuram Santosham and Robert E. Black.

February 20, 2012 • THE GAZETTE

Classifieds APARTMENTS/HOUSES FOR RENT

Brewers Hill, 2BR, 2.5BA rehab, gourmet kitchen, fin’d bsmt, deck, no pets. $1,850/ mo. 410-303-1214 or hudsonstreetrental@ hotmail.com. Charles Village, lg 1BR apt in the Marylander, avail until March 10, spacious, semifurn’d, 2-min walk to JHU shuttle stop, ideal for a student. $450/3 wks incl utils. sumerabhojani@hotmail.com. Deep Creek Lake/Wisp, cozy 2BR cabin w/ full kitchen; call for wkly/wknd rentals. 410638-9417 or jzpics@yahoo.com (for pics). Evergreen (Roland Park), 1BR apt on 2nd flr, priv entry, avail late Feb. $850/mo incl utils. Becky, 410-889-9336. Fells Point, 2BR, 1.5BA TH, remodeled kitchen, granite counters, stainless steel appls, hdwd flrs, priv brick patio, avail in June. mgood08@gmail.com or www.postlets .com/rtpb/6981560. Hamilton Ave (at Walther), 2BR, 1BA apt, 1st flr. $750/mo. 301-538-3819. Miles Ave (at 28th St), 2BR TH, completely renov’d, 1 full BA. $900/mo. 443449-4883. Ocean City (144th St), 5BR semi-detached beach house on ocean block, call for wkly rates. 410-821-6446, rme@nqgrg.com or community.webshots.com/user/easushko (for pics). Ocean City (137th St), 3BR, 2BA condo, steps from beach, lg pool, 2 prkng spaces, short walk to restaurants and entertainment, call now for prime wks. 410-544-2814. Owings Mills, lovely 3BR colonial, excellent commuter location, train line direct to JHMI. $1,800/mo. 410-833-0593 or wsunde@verizon.net. Owings Mills Newtown, spacious 3BR, 2.5BA TH w/fin’d walkout bsmt, deck/ patio, nr schools/shops/JHU metro. $1,700/ mo. 410-504-5601 or jsethi33@yahoo.com.

M A R K E T P L A C E

secure bldg, steps from Homewood campus. $89,500 (reduced). 443-414-6282. Owings Mills New Town, 2BR condo nr metro station. www.4409silverbrook.info. Stewartstown, PA, rancher on priv lane, 2,170 sq ft, 1 acre, stick built w/bsmt, many updates, exit 4 off I-83. $324,500. 410-9772103. Renov’d 2BR, 2BA TH w/den, new kitchen, new BAs, windows, HVAC, plumbing, elec, rec rm, blks to JHH, LNYW grant $ to fulltime employees. 410-404-7072. House nr Bayview/JHMI, 3 fin’d levels, lg renovation, separate garage w/water, electric and priv patio, spacious kitchen w/granite counters, woodburning fp, bsmt boasts tall ceilings, fully fin’d living area, expos’d brick, hdwd flrs throughout. 410-967-4119 or prpletanzanite11@yahoo.com.

ROOMMATES WANTED

BR in Eastwood, new rehab, 5 mins to JH Bayview, avail month to month. $675/mo + sec dep. 410-236-4052. Nonsmoker wanted for rm in 3BR, 1.5BA Butchers Hill RH, pref quiet, serious Hopkins affiliate, easy 10-min walk to SoM/SPH/SoN, CAC, W/D, balcony. $500/mo + utils. Chip, 443-844-7712 or chiphawk@gmail.com. F wanted to share lg apt in Towson area, priv BR w/full BA,use of W/D, common areas, pool, Dish TV/Internet, quiet, upscale area. $725/mo incl all utils. 443-465-7011 or junedameron@gmail.com. Rm avail in lg, furn’d house in Catonsville, W/D, deck, backyd, nr park, nr I-69/I-95, no lease, high-speed Internet incl’d. $600/mo + utils. 410-409-0692 or lizo99@hotmail .com. Share 3BR home 10 mins from E Baltimore campus in Belair/Edison community, W/D. $600/mo incl utils, wireless Internet. 443226-6497 or expoblk@yahoo.com.

Owings Mills, 2BR, 2BA TH, lg kitchen, W/D, free prkng, avail June 1, nr metro station, 30 mins to JHMI. gsimon1977@ yahoo.com.

F nonsmoker bedspacer wanted to share condo in Washington Hill (98 N Broadway) w/grad student, adjacent to Church Professional Building, walk to JHH/shuttle. $450/ mo + utils. retzcare@yahoo.com.

Rehoboth Beach, 3BR TH, 15-min walk to beach, dog-friendly, wkly rentals, JHU discounts for summer 2012. galeeena@yahoo .com.

F wanted to share 2BR, 1BA apt w/nurse, living rm, kitchen. $575/mo incl utils, cable TV, wireless Internet. 302-724-0044.

Remington (29th St at Miles), 2BR, 1BA TH w/kitchen, living rm, bsmt, fenced yd, dogs OK, no smokers, 5-min walk to Homewood campus. $780/mo + utils. 443-7835666 or lilly7772011@gmail.com.

F wanted for lg 1BR w/priv BA nr JHH/SoN, high-speed Internet, good view. $650/mo + utils. myhome.2011@yahoo.com.

polish, in excel cond, Hobart M. Cable grand bench incl’d, tuned annually. $6,320. Treva, 410-519-5879 or 443-306-4005. Red Cross pins from USSR, Russia, Ukraine, 15 different pins. $28. 443-517-9029 or rgpinman@aol.com. Playboy mags (1965–2007), sold as lot or separately; exterior French doors (2); vintage water skis; Dior full-length silver fox coat; vintage Maryland maps; ceramic electrical insulators, music cassette tapes (lot of 276); fitness chair; 21" TV; 35mm cameras; office supplies. 443-824-2198 or saleschick2011@hotmail.com. Oil-filled heaters (3), inkjet printer, portable canvas chair, sand beach chairs (2), keyboard case, 100W amplifier. 410-4555858 or iricse.its@verizon.net. Dell Inspiron 8100 and 8200, w/dock stations, $130 and $150; Toshiba Satellite L25, $100; eMachine 330 w/monitor, $70; HP ScanJet 4570c scanner, $50; 13” and 21” Sony TVs w/HDTV antenna and digital converters, $60 and $120; NuWave cooker, $60; bread maker, $30; rice cooker, $25; Belgian waffle maker, $15. 410-812-9267 or azhelon@gmail.com. Maple mate’s chair, brass tacks, leather seat and trim; also 6 antique oak dining chairs w/cane panels, velvet seats. 410-242-5071 or johannecoll@hotmail.com. Furnish your apt: Full-size mattress and boxspring, beautiful Chippendale-like walnut corner china cabinet, loveseat, microwave, art, dishes. $500/all (or best offer). furnishmyapt@gmail.com.

SERVICES/ITEMS OFFERED OR WANTED

Responsible, loving pet-, baby- or housesitter avail, JHU employee, has experience with special needs children, cats and dogs, refs avail. 202-288-1311 or janyelle.thomas@ gmail.com. Want to buy: Johns Hopkins Green Bag that was distributed a few yrs ago, contact me with your price. 410-484-1954 or 443506-2378 (cell).

Can your writing use a good editor? Highly experienced copy editor can help, student/ prof’l work welcome, reasonable rates. Michael, 410-802-6111 or maaron1201@ gmail.com. Editing of biomedical journal articles and grant applications. 443-600-2264 or michellejones@jonesbiomediting.com. Raise your income, join fast-growing Lia Sophia team, $50 per hr average. 410828-4743 or www.liasophia.com/regional/ butterfly-stories (for more info). Friday Night Swing Dance Club, open to public, great bands, no partners necessary. 410-663-0010 or www.fridaynightswing.com. Affordable and professional landscaper/certified horticulturist available to maintain existing gardens, also designing, planting or masonry; free consultations. David, 410683-7373 or grogan.family@hotmail.com. Licensed landscaper avail for fall/winter lawn maintenance, yard cleanup, leaf/snow removal, trash hauling. Taylor Landscaping LLC. 410-812-6090 or romilacapers@ comcast.net. Hauling/junk removal, next-day pick up, free phone estimate, 15% discount all Hopkins. 410-419-3902. Tai chi: Beginners classes starting in Charles Village and Towson. 410-296-4944 or www .baltimoretaichi.com. Tutor available: all subjects/levels; remedial, gifted; help w/college counseling, speech and essay writing, editing, proofreading. 410-337-9877 (after 8pm) or i1__@hotmail .com. Transmission repairs, rebuilt or used, 20% discount for all JHU faculty, staff, students and employees, free estimate. Bob, 410574-8822. Looking for computer guru to teach me how to use new Apple iMac and printer. Jim, 410-366-7191 or jwilli33@gmail.com. Pet consultant service offering dog obedience training. 410-710-9191 or www .gilbertspetconsulting.webs.com.

PLACING ADS Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines: • One ad per person per week. A new request must be submitted for each issue. • Ads are limited to 20 words, including phone, fax and e-mail.

• We cannot use Johns Hopkins business phone numbers or e-mail addresses. • Submissions will be condensed at the editor’s discretion. • Deadline is at noon Monday, one week prior to the edition in which the ad is to be run. • Real estate listings may be offered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.) Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attachments) to gazads@jhu.edu; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Baltimore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 443-275-2687.

CARS FOR SALE HOUSES FOR SALE

Fells Point, 3-story TH w/lg private yd, 4 blks to JHH. 410-419-3902. Gardenville, 3BR, 1.25BA RH, new kitchen and BA, CAC, hdwd flrs, fenced, maintenance-free yd w/carport, club bsmt w/cedar closet, quiet neighborhood, 15 mins to JHH. $120,000. 443-610-0236 or tziporachai@ juno.com. Greenway, Manhattan-style efficiency condo in owner-occupied, elegant and

ROLAND PARK Fabulous, bright, sunny, spacious duplex condo in Victorian style 14 unit bldg. at 4202 Roland Ave. One parking space, HWD FL., wood burning fireplace, 2 balconies. 2 Master Bedrooms/ Baths. Laundry on BD level. Lg. kit & DR, 1/2BA, New HVAC.$190,000. Call Pat Perkins 410-338-1684, or pbpcfr@aol.com.

’98 Toyota Avalon Gold Pkg, automatic transmission, has a clean record, 80.35K mi. $5,500. 217-721-8187 or buysunshinetoday@ gmail.com.

Woodcliffe Manor Apartments

S PA C I O U S

G A R D E N A PA RT M E N T L I V I N G I N

R O L A N D PA R K

• Large airy rooms

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• Hardwood Floors • Private balcony or terrace • Beautiful garden setting

ITEMS FOR SALE

• Private parking available

Hobart M. Cable baby grand piano, ebony

• University Parkway at West 39th St.

2 & 3 bedroom apartments located in a private park setting. Adjacent to Johns HICKORY HEIGHTS WYMAN COURT Hopkins University Homewood Campus and minutes from downtown Baltimore. Just Renovated! A lovely hilltop setting

Beech Ave. adj. to JHU!

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105 West 39th St. • Baltimore, MD 21210 Managed by The Broadview at Roland Park BroadviewApartments.com

12 THE GAZETTE • February 20, 2012 F E B .

2 0

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2 7

Calendar COLLOQUIA Tues., Feb. 21, 4 p.m. “Bembe and the Outside: Exteriority and Creole Becoming in a Central Cuban Praise Feast,” an Anthropology colloquium with Todd Ochoa, University of North Carolina, Chapel Hill. 404 Macaulay.

Wolfgang Holzmair, left, considered by many the leading ‘lieder’ baritone of his generation, performs Schubert’s epic song cycle ‘Winterreise’ without intermission. Joining him on the piano is his longtime recital partner, Russell Ryan. See Music.

“Transition Metal Complexes as Functional Mimics of Metalloenzymes That Process O2 or NO,” a Chemistry colloquium with Andreja Bakac, Iowa State University. 233 Remsen. HW Tues., Feb. 21, 4:15 p.m.

Thurs., Feb. 23, 3 p.m. “ ‘A Special Baltimore Problem’: Tuberculosis Control, 1950–80,” a History of Science, Medicine and Technology colloquium with Julia Cummiskey, SoM. Seminar Room, 3rd floor, Welch Medical Library. EB

DISCUSSION/ TALKS Tues., Feb. 21, 5 p.m. “Stagnation vs. Transformation: Prospects for Russia’s Democratic Evolution and European Integration,” a SAIS European Studies Program panel discussion, with students who have recently returned from a field trip to Moscow; Mitchell Orenstein, SAIS; and Henry Hale, George Washington University. For more information, call 202-663-5796 or ntobin@jhu.edu. 806 Rome Bldg. SAIS Wed.,

Feb.

22,

12:30

p.m.

“Why Repeated Elections Don’t Always Lead to Better Democracy: The Case of Cote d’Ivoire and the Need for Stronger Institutions,” a SAIS African Studies Program discussion with Maja Bovcon, University of Oxford. For information, call 202-663-5676 or email itolber1@jhu.edu. 736 Bernstein-Offit Bldg. SAIS “Sustaining Economic Growth in China,” a SAIS China Studies Program discussion with Nicholas Lardy, Peterson Institute for International Economics. For information or to RSVP, email zji@jhu .edu. Kenney Auditorium, Nitze Bldg. SAIS

Wed., Feb. 22, 5 p.m.

Thurs., Feb. 23, 3 p.m. “Arab Spring: What About Algeria?” a SAIS Center for Transatlantic Relations panel discussion with Alexis Arieff, Congressional Research Service; John Entelis, Fordham University; Eric Goldstein, Human Rights Watch; Daniele Moro and Daniel Serwer, both of SAIS. For more information or to RSVP, go to www.eventbrite .com/event/2920851345/mcivte. 500 Bernstein-Offit Bldg. SAIS

F I L M / V I D EO

Screening of the film Talk to Me,” part of the SAIS African Diaspora AssoFri., Feb. 24, 3:30 p.m.

a Mental Health thesis defense seminar with Sachiko Kuwabara. 244 Hampton House. EB “Bayesian Nonparametric Methods for Complex Dynamical Phenomena,” a Center for Language and Speech Processing seminar with Emily Fox, University of Pennsylvania. B17 Hackerman. HW

Tues., Feb. 21, noon.

“Epigenetic Regulation by Heterochromatin, Noncoding RNAs and RNA Quality Control,” a Biological Chemistry seminar with Ke Zhang, NCI/NIH. Mountcastle Auditorium, PCTB. EB

L E C T URE S

Dean’s Lecture II—“The Widening Gyre: Biomedical Education in the Age of Information Overload” by Jon Lorsch, SoM. Hurd Hall. EB

Mon., Feb. 20, 4 p.m.

“Hippo Signaling in Development and Cancer,” an Institute of Genetic Medicine lecture by Duojia Pan, SoM. G-007 Ross. EB

Wed., Feb. 22, 2 p.m.

Thurs.,

Feb.

23,

8:30

a.m.

“Melanoma/Immunotherapy,” a Sidney Kimmel Comprehensive Cancer Center visiting professor lecture by F. Stephen Hodi Jr., Harvard Medical School. Owens Auditorium, CRB. EB The Tudor and Stuart Lecture—“On Beauty as Beautiful? The Problem of Novelistic Aesthetics by Way of Zadie Smith” by Dorothy Hale, University of California, Berkeley. Sponsored by English. 130D Gilman. HW

Thurs., Feb. 23, 4 p.m.

MUSIC

The Shriver Hall Concert Series presents baritone Wolfgang Holz mair and pianist Russell Ryan performing Schubert’s epic song cycle Winterreise. (See photo, this page.) $38 general admission, $19 for non-JHU students; free for JHU students. Shriver Auditorium. HW Sun., Feb. 26, 5:30 p.m.

in Bacteria and Eukaryotes,” an Institute for Biophysical Research seminar with Rachel Green, SoM. Part of the Chalk It Up to Biophysics series. 111 Mergenthaler. HW Mon.,

Mon., Feb. 20, noon. “Estrogen and Prostate Cancer—An Update,” a Biochemistry and Molecular Biology seminar with Shuk-mei Ho, University of Cincinnati. W1020 SPH. EB

“Quality Control During Translation

Mon., Feb. 20, noon.

20,

12:15

p.m.

“Study of Risk Genes for Schizophrenia in Neural Development,” an Institute of Genetic Medicine/Human Genetics Graduate Program thesis defense seminar with Eunchai Kang. G-007 Ross. EB

Mon., Feb. 20, 1 p.m.

Mon., Feb. 20, 1:30 p.m. “Iron Oxide Nanoparticles as MRI Contrast Agents to Track Immune Responses,” a Biomedical Engineering seminar with Chien Ho, Carnegie Mellon University. 709 Traylor. EB (Videoconferenced to 110 Clark. HW )

“Assessing the Effect of Organ Transplantation on the Distribution of Residual Lifetime,” a Biostatistics seminar with David Vock, North Carolina State University. W2030 SPH. EB

Mon., Feb. 20, 4 p.m.

Mon.,

Feb.

20,

4:30

p.m.

“Locally Standard Geometries and Algebraic Structures,” a Topology seminar with David Ayala, Harvard University. Sponsored by Mathematics. 308 Krieger. HW Tues.,

S E M I N AR S

Feb.

“Looking Into the Dark: Understanding Melanoma Initiation Using the Zebrafish,” a Carnegie Institution Embryology seminar with Craig Ceol, University of Massachusetts Medical School. Rose Auditorium, 3520 San Martin Drive. HW

Feb.

21,

10:45

a.m.

“Machine Learning in the Bandit Setting: Algorithms, Evaluation and Case Studies,” a Computer Science seminar with Lihong Li, Yahoo Research. B17 Hackerman. HW

“Exploring Methods and Conceptual Approaches for Studying Positive Adaptation in Displaced Youth,”

Tues., Feb. 21, 11 a.m.

Thurs., Feb. 23, 12:15 p.m.

Mental Health Noon Seminar— “Research on the Effectiveness of the Family Check-up” with Thomas Dishion, Arizona State University. B14B Hampton House. EB

Tues., Feb. 21, noon.

Thurs., Feb. 23, noon. The Bromery Seminar—“Dune Motion and Sand Flux on Mars” with Nathan Bridges, APL. Sponsored by Earth and Planetary Sciences. Olin Auditorium. HW

Tues., Feb. 21, noon. “Beyond the Immune: Macrophages in Reproductive and Stem Cell Biology,” a Biochemistry and Molecular Biology seminar with Tony DeFalco, Duke University Medical Center. W1020 SPH. EB

Thurs., Feb. 23, 1:30 p.m.

“Hot Topics in Doctoral Research,” a Graduate Seminar in Injury Research and Policy with doctoral candidates Michael Kim and David Swedler. Sponsored by the Center for Injury Research and Policy. W2008 SPH. EB

Thurs.,

Tues., Feb. 21, 12:10 p.m.

ciation’s Black History Month movie series. For information or to RSVP, email ada.hopkins@gmail .com. 806 Rome Bldg. SAIS

Dimensional Data,” a Biostatistics seminar with Daniela Yang, Wharton School, University of Pennsylvania. W2030 SPH. EB

Tues.,

Feb.

21,

1:30

“Tackling Hard Combinatorial Optimization Problems via Negatively Correlated Rounding,” an Applied Mathematics and Statistics seminar with Rico Zenklusen, MIT. 304 Whitehead. HW Feb.

23,

p.m.

“Automated RNA Structure Characterization From HighThroughput Chemical Mapping Experiments,” an Electrical and Computer Engineering seminar with Sharon Aviran, University of California, Berkeley. 132 Gilman. HW

p.m.

“Optimally Fragmenting Graphs Against Stochastically Located Threats: Containing Wildfire, Invasive Species and Epidemics,” an Applied Mathematics and Statistics seminar with Gwen Spencer, Cornell University. 304 Whitehead. HW

Thurs., Feb. 23, 3 p.m. “LongRange Mechanical Force Enables Scaffold-Free Self-Assembly of Epithelial Tubules,” a Mechanical Engineering seminar with Chin-lin Guo, Caltech. 210 Hodson. HW

“Epigenetic Regulation by Heterochromatin, Noncoding RNAs and RNA Quality Control,” a Biology special seminar with Ke Zhang, NCI/NIH. 100 Mudd.

Thurs., Feb. 23, 4 p.m.

“Plasma Glial Fibrillary Protein as a Biomarker of Prevalent and Incident Cerebrovascular Injury in Children,” a Graduate Training Program in Clinical Investigation thesis defense seminar with William Savage. W2033 SPH. EB

Tues., Feb. 21, 3 p.m.

“Imaging and Sequencing of Single Molecules in Individual Cells,” a Biology special seminar with Chenghang Zong, Harvard University. 100 Mudd. HW

Tues., Feb. 21, 4 p.m.

“The Double-Edged Sword of Notch Signaling in Cancer,” a Pathology seminar with Jon Aster, Harvard Medical School. 490 Rangos. EB

Wed., Feb. 22, noon.

Wed., Feb. 22, 12:15 p.m. “A Cluster-Based Randomized Controlled Trial Promoting Community Participation in Arsenic Mitigation,” an International Health seminar with Christine Marie George, Columbia University. W3008 SPH. EB

“Origins of Catalytic Power in Computationally Designed Enzymes,” a Biophysics and Biophysical Chemistry seminar with Jonathan Lassila, Stanford University School of Medicine. 701 WBSB. EB

Wed., Feb. 22, 1:30 p.m.

“DNA Topoisomerase I: An Essential Enzyme and a Drug Target,” a Pharmacology and Molecular Sciences seminar with Yves Pommier, National Cancer Institute. West Lecture Hall (ground floor), WBSB. EB

Wed., Feb. 22, 4 p.m.

“Singluar Value Decomposition for High-

Wed., Feb. 22, 4 p.m.

HW Thurs., Feb. 23, 5 p.m. “Killing Time, Saving Time: Calendars and the Holocaust,” a Leonard and Helen R. Shulman Jewish Studies Program seminar with Holocaust scholar and educator Alan Rosen. Smokler Center for Jewish Life (Hillel). HW

“Chemokine Receptor 5 Inhibition Prevents SIV-Induced Cardiac Dysfunction” with Katie Brennan, SoM, and “Fenbendazole Treatment of Mice: Potential Pitfalls” with Tracey Graham, SoM, a Molecular and Comparative Pathobiology seminar. West Room (ground floor), BRB. EB

Fri., Feb. 24, 1 p.m.

Continued on page 10

(Events are free and Calendar open to the public Key except where indicated.) APL BRB CRB EB HW JHOC

Applied Physics Laboratory Broadway Research Building Cancer Research Building East Baltimore Homewood Johns Hopkins Outpatient Center KSAS Krieger School of Arts and Sciences NEB New Engineering Building PCTB Preclinical Teaching Building SAIS School of Advanced International Studies SoM School of Medicine SoN School of Nursing SPH School of Public Health WBSB Wood Basic Science Building WSE Whiting School of Engineering