The Gazette -- September 28, 2009 by The Johns Hopkins University

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September 28, 2009

The newspaper of The Johns Hopkins University

Volume 38 No. 5

E V E N T

R E S E A R C H

Great Scott: Fitzgerald’s Baltimore

JHU passes $100 mill in ARRA funds By Lisa De Nike

Homewood

Continued on page 5

W ILL KIR K / H OM EW OOD PH OT O.JH U .ED U

he Johns Hopkins University has won 250 research grants, totaling more than $114 million, through provisions in the federal stimulus package designed to advance scientific and medical knowledge while jump-starting the U.S. economy. The grants will Grants underwrite invessupport 250 tigations ranging from what strategies projects, are best motivate drug addicts coming out of in-patient rehagenerating bilitation to enroll in sobriety support jobs programs, to the role that certain proteins play in the development of muscle-wasting diseases such as muscular dystrophy. Equally as important, however, the grants are generating jobs at Johns Hopkins and fueling regional economic activity, as employees spend their paychecks and Johns Hopkins laboratories hire personnel and buy supplies. The federal stimulus package, passed by Congress in February and formally known as the American Recovery and Revitalization Act of 2009, provided the National Institutes of Health and the National Science Foundation with $12.4 billion in additional money to underwrite research grants by September 2010. As of this month, Johns Hopkins researchers have submitted nearly 1,300 proposals for stimulus-funded projects. “This milestone is a testament to the outstanding research that our worldclass faculty is conducting across the university,” said Lloyd Minor, provost and senior vice president for academic affairs. “They have responded to the opportunities created by the stimulus package with the drive, commitment and entrepreneurial spirit that continues to distinguish Johns Hopkins.” Scott Zeger, vice provost for research, said, “Johns Hopkins faculty and staff have once again risen to the challenge

Johns Hopkins Fitzgerald scholars John Irwin and John D. Rockefeller V in front of the university’s Wolman Hall, where the author lived in the 1930s, when the building was the Cambridge Arms Apartments.

ven the great ones get writer’s block. F. Scott Fitzgerald described such a circumstance—and how he nudged himself out of it with a bus trip, a leisurely stroll and a trip to his local barbershop—in an article titled “Afternoon of an Author,” published in Esquire in 1936. The author starts his story in the kitchen

Scholars, fans of author’s work gather in the city he once called home By Greg Rienzi

The Gazette

P U B L I C

of his top-story apartment. He writes how he looked out the window during breakfast “at students changing classes on the college campus across the way.” The college he refers to was Johns Hopkins; the campus, Homewood. He wrote those words when he lived in the Continued on page 4

H E A L T H

Racial disparities in diabetes tied to living conditions By Tim Parsons

School of Public Health

he higher incidence of diabetes among African-Americans when compared to whites may have more to do with living conditions than genetics, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. The study, available online in advance of publication in the October edi-

In Brief

Launch of stem cell Web site; World Bank’s Zoellick on economic crisis; Best Dressed Sale

tion of the Journal of General Internal Medicine, found that when African-Americans and whites live in similar environments and have similar incomes, their diabetes rates are similar, a finding that contrasts with the fact that diabetes is more prevalent nationally among African-Americans than whites. Researchers from the Hopkins Center for Health Disparities Solutions and Case Western Reserve University School of Medicine compared data from the 2003 National Health Interview Survey with the

C A L E N D AR

SAIS ‘Cultural Conversations’; Chinese Mid-Autumn Festival; J-Share workshop

Exploring Health Disparities in Integrated Communities Southwest Baltimore Study. The Baltimore study, known as EHDICSWB, was conducted in a racially integrated urban community without race differences in socioeconomic status. In recent decades the United States has seen a sharp increase in diabetes prevalence, with African-Americans having a considerably higher occurrence of type 2 diabetes Continued on page 8

10 Job Opportunities 10 Notices 11 Classifieds

2 THE GAZETTE • September 28, 2009

Nursing receives prestigious WHO redesignation School of Nursing

he Johns Hopkins University School of Nursing has earned the World Health Organization’s regional Pan American Health Organization redesignation as a collaborating center for nursing information, knowledge management and sharing. Of the 46 nursing programs worldwide that are WHO collaborating centers, Johns Hopkins’ is the only one with information and communications technology as its focal point. Overall, WHO has 800 collaborating centers in 90 countries, covering such areas as occupational health, communicable diseases, nutrition, mental health, chronic diseases and health technologies. The redesignation runs through August 2013 and can be further renewed. The initial designation was in 2005. Patricia Abbott, co-director of the school’s Collaborating Center for Knowledge, Information Management and Sharing, said that the WHO redesignation recognizes the center’s being “way, way out in front of the curve” in harnessing information communications technology, or ICT, to improve the exchange of health information. “The world is moving toward understanding the power of information technology in health,” she said. “[The Johns Hopkins School of Nursing] figured out early on that there’d be a surge in ICT and health. The WHO has concomitantly begun to harness the power of IT in health. With our expertise in that area,

and our extensive, worldwide nursing outreach, [the School of Nursing] is very well-positioned to capitalize upon the changing global landscape.” Among the contributions that the center had made in sharing its expertise with nurses, midwives and other medical professionals abroad is tailoring its packaging of information to the limited bandwidth capabilities in many developing countries. More than 2,000 medical professionals from 136 countries are active in the school’s Global Alliance of Nursing and Midwifery, where they share best practices and network electronically. Abbott serves as GANM’s moderator. “Hundreds of exchanges have been facilitated by GANM,” Abbott said, noting, for example, a primary care physician in Diyala province, Iraq, who sought advice on addressing a measles outbreak under combat conditions; respondents included retired American nurses who had served in Vietnam. In another instance, health workers serving the Inuit population in Canada’s Northwestern Territories were advised by nurses in Bolivia on how best to work with indigenous peoples. “I’m looking at it, thinking, These people never would have met otherwise, and the knowledge in our heads would not have been shared with those who need it the most,” Abbott said. “For me as a nurse, it’s been incredibly rewarding and humbling. It opens the channels of communication. All of a sudden, geography becomes irrelevant; we are able to reach out, share our knowledge for the good of people all over the world”

I N B R I E F

Web site on Johns Hopkins stem cell research is launched

n conjunction with last week’s 2009 World Stem Cell Summit, co-hosted by Johns Hopkins and held in Baltimore, Johns Hopkins Medicine launched an interactive Web site on which its researchers and clinicians collectively describe their explorations into stem cell biology and engineering. The multimedia production, which went live Sept. 21 at www.hopkinsmedicine.org/ stem_cell_research, emphasizes applications of stem cell technologies in regenerative medicine and underscores the collaborative effort that is fundamental to translational research. The site includes everything from a narrated timeline of stem cell research to a video feature of a Johns Hopkins patient, physician and bench scientist who are linked by stem cell research as it relates to Parkinson’s disease. Johns Hopkins experts also weigh in on state-of-the-art issues of ethics and safety as they apply to stem cells.

Head of World Bank to speak at SAIS on economic crisis

orld Bank Group President Robert B. Zoellick will assess the political and economic impact of the global economic crisis, and its implications for development and globalization, in a speech at SAIS at 11 a.m. today, Sept. 28. He will deliver this speech shortly before the World Bank/International Monetary Fund Annual Meetings in Istanbul, Turkey. The event will be held in the Nitze Building’s Kenney Auditorium. Non-SAIS affiliates should RSVP to saispubaffairs@jhu .edu or 202-663-5644. Zoellick’s speech will be live-streamed on www.sais-jhu.edu/newsand-events/zoellick. A video and a copy of his prepared remarks will be available after the event at www.sais-jhu.edu.

Women’s Board’s Best Dressed Sale returns to Evergreen

he Johns Hopkins Best Dressed Sale and Boutique, a fund-raiser of the Women’s Board of The Johns Hopkins Hospital, returns this weekend to the Carriage House at Evergreen Museum & Library. Now in its 42nd year, the sale—which in recent years has raised $150,000 for patient care at the hospital—offers gently used and some new clothing for women, including designer dresses and shoes, vintage apparel, furs, shoes, accessories and wedding gowns; children’s wear; and a large selection of men’s suits, coats, jackets, formal wear and ties. The event begins on Thursday, Oct. 1, with pre-sale shopping, fashion consultations and light refreshments ($40 in advance, $45 at the door) from 4 to 8 p.m. and continues (free admission) from 9 a.m. to 6 p.m. on Friday, Oct. 2; 10 a.m. to 5 p.m. on Saturday,

Editor Lois Perschetz Writer Greg Rienzi Production Lynna Bright Copy Editor Ann Stiller Photography homewoodphoto .jhu.edu A d v e rt i s i ng The Gazelle Group Business Dianne MacLeod C i r c u l at i o n Lynette Floyd Webmaster Tim Windsor

Oct. 3; and 11 a.m. to 4 p.m. on Sunday, Oct. 4, when most items are half price. For more information, including how to buy tickets for the pre-sale, go to www .womensboard.jhmi.edu/bds_buyers.cfm.

‘Lighter Than Air’ author to give JHU Press lunch talk

HU Press author Tom D. Crouch will discuss his book Lighter Than Air: An Illustrated History of Balloons and Airships in this month’s installment of the Press’ lunch and lecture series, to be held at 12:30 p.m. on Thursday, Oct. 8, at the Johns Hopkins Club. An award-winning aeronautical historian and the senior curator of the Division of Aeronautics at the Smithsonian’s National Air and Space Museum, Crouch will explore the history that starts with Archimedes’ discovery of the principle of buoyancy and continues with the latest in sport balloons and plans for future airships. Admission is $18, and seating is limited. Johns Hopkins Club members should contact the club to make reservations; nonmembers should contact Jack Holmes at 410-516-6928 or jmh@jhu.edu.

Historic multiple kidney swap ops featured on ‘Dr. Oz Show’

obert A. Montgomery, director of the Johns Hopkins Comprehensive Transplant Center, and 11 Johns Hopkins patients who were part of the first eight-way, multihospital, domino kidney transplant this summer, were featured last week on the new Dr. Oz Show. The segment, which aired Sept. 24, was recorded in New York earlier in the month. “I think this was an excellent venue to increase awareness for kidney paired donation and the alarming fact that we are in a midst of a crisis in organ transplantation in this country,” Montgomery said. “I hope the segment will answer viewers’ questions about kidney donation and possibly encourage them to help those in need by being donors.”

Social Innovation Fund is topic of Social Policy Seminar

obert T. Grimm Jr., director of Research and Policy Development at the Corporation for National and Community Service, will be the speaker at the Social Policy Seminar Series scheduled for 4 p.m. on Thursday, Oct. 1, in 526 Wyman Park Building, Homewood campus. His topic is “Scaling Great Ideas That Work: The Social Innovation Fund.” Grimm is currently overseeing the implementation of the Social Innovation Fund and other initiatives authorized by the 2009 Edward M. Kennedy Serve America Act. He is co-author of the cover article in the Winter 2009 issue of the Stanford Social Innovation Review titled “The New Volunteer Workforce.”

C o nt r i b u t i ng W r i t e r s Applied Physics Laboratory Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Audrey Huang, John Lazarou, David March, Katerina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort

The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date. Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 410343-3362 or gazellegrp@comcast.net.

September 28, 2009 • THE GAZETTE

Research universities launch online news compendium Futurity spotlights latest discoveries in science, health, other disciplines By Greg Rienzi

The Gazette

he Johns Hopkins University and 34 other leading U.S. research universities have launched Futurity, an online news source that spotlights the latest discoveries in science, engineering, health, the environment and other disciplines. Futurity, which debuted Sept. 15 at www .futurity.org, offers the public direct access to research breakthroughs conducted at the participating institutions. The stories, based mostly on press releases disseminated by the universities, are written for a lay audience. The site carries no advertising. Dennis O’Shea, executive director of communications and public affairs for Johns Hopkins, said that research institutions have been looking for new ways to reach out to the public and share this information. Futurity, he said, will bring attention to research

that may go unreported or otherwise fall under the radar. “Mainstream news outlets—newspapers, networks, cable channels—have cut way back on science coverage,” O’Shea said. “In addition, many of the audiences interested in this type of news have migrated away from newsprint or television to the Web.” O’Shea said that the site also allows the public to see how federal, state and private funding are being put to use by universities to address critical challenges. “Futurity is an online place where universities work together to tell research stories and, more broadly, to tell the story of research and how it makes the world a better place,” he said. Futurity co-founder Michael Schoenfeld, vice president for public affairs and government relations at Duke University, said that it’s unique to see so many high-powered universities working together in such a collaborative way. “That fact alone indicates the project’s significance. Universities are the world’s laboratories. They host the brightest minds working to answer some of today’s most urgent questions,” Schoenfeld said. “The breadth and caliber—and the collective

force—of the research featured on Futurity is truly extraordinary.” The stories are organized into four subject groups: Earth and Environment, Health and Medicine, Science and Design, and Society and Culture. In addition to the story itself, the news packages include photos, illustrations and/or videos. The site is drawing attention. In its first two days, Futurity attracted 13,800 visits and 46,600 page views. Lisa Lapin, assistant vice president for communications at Stanford University, said that Futurity is looking for new ways to extend the site’s reach. “We’re active on Twitter, Facebook and YouTube. We’re also in partnership talks with major Internet news providers. Today’s online environment is perfectly suited for this type of direct communication,” she said. Lapin says that the site is designed to encourage interaction. Stories include links to published reports and supplemental materials that allow readers to explore topics in more detail. The site is available in a mobile-friendly version, and visitors can comment on stories and sign up for a daily e-mail update. Johns Hopkins, like all the current part-

ner universities, is a member of the Association of American Universities, a nonprofit organization of leading public and private research universities. Futurity has featured a number of studies by Johns Hopkins scientists to date, including a report on how new computer software is sifting through hundreds of genetic mutations to highlight the ones most likely to promote cancer. The site has also featured Johns Hopkins–led research on helicopter crashes in Hawaii, the use of Legos to visualize life at the nanoscale and lung cancer treatments for “never-smokers.” In addition to Johns Hopkins, the participating schools are Brown; Carnegie Mellon; Case Western Reserve; Cornell; Duke; Emory; Iowa State; McGill; Michigan State; NYU; Northwestern; Penn State; Princeton; Rice; Rutgers; Stanford; Stony Brook; Tulane; University of California, Berkeley; University of California, Irvine; University of Chicago; University of Colorado, Boulder; University of Iowa; University of Kansas; University of Michigan; University of North Carolina, Chapel Hill; University of Pennsylvania; University of Rochester; University of Southern California; University of Texas, Austin; University of Washington; Vanderbilt; Washington University in St. Louis; and Yale.

NIH Pioneer, Innovator awards go to Johns Hopkins scientists B y K at e r i n a P e s h e va

Johns Hopkins Medicine

Johns Hopkins scientist who proposes to manipulate forces to activate enzymes in live cells and a researcher who has developed a way to hunt down tuberculosis germs with real-time imaging have received a total of $4 million in special awards from the National Institutes of Health. Jin Zhang, an associate professor of pharmacology in the School of Medicine, is one of 18 winners this year of a Director’s Pioneer Award, which confers $2.5 million in direct funding over five years to develop a novel technology for venturing inside cells and manipulating single molecules in their “native” habitat. Sanjay Jain, a Johns Hopkins Children’s Center infectious disease specialist, earned a New Innovator Award, which is given to scientists in the early stages of their careers and comes with $1.5 million in direct funding over five years. Jain, one of 55 Innovator Award recipients this year, has designed an imaging technique to monitor in real time

the drug-evading behavior of Mycobacterium tuberculosis in test animals. The ability of the TB bacterium to hide out in the body for decades contributes to the disease’s virulence and persistence in humans. Zhang’s proposed technology would offer scientists new tools not only to see clearly how molecules act inside living cells but also to manipulate those actions. “Molecules behave differently in their native environments, where they interact with neighbor molecules to regulate cells, tissues and organs,” she said. “So that is where we need to watch and maneuver them.” To that end, Zhang says she wants to make a “probe” with magnetic properties that can be grown inside cells and would allow researchers to apply force and maneuver molecules within the cells. She says that understanding the native behavior of molecules linked to cell movement, growth and maturity is likely to shed light on cellular processes linked to cancer and other diseases. “Jin’s research has already revolutionized our understanding of how cells process information,” said Philip A. Cole, MarshallMaren Professor and director of the Depart-

ment of Pharmacology and Molecular Sciences in the School of Medicine. “With the NIH Pioneer Award, she has the potential to gain unprecedented precision in activating molecules inside the cell and pave the way for new cures for a range of diseases including cancer, heart disease and immune disorders.” Jain’s monitoring system works by infecting animals with “designer” strains of TB, developed by Johns Hopkins investigators to absorb radioactive tracing chemicals. The chemicals light up the germ and any infected tissues in the lung, allowing an image to be captured by CT, PET and SPECT scanners. The resulting pictures allow scientists to detect the exact location of active bacterial reservoirs. New strains to be developed as part of the project will help scientists pinpoint dormant bacterial hideouts containing sleeper cells, which do not cause active disease but of which there are 2 billion cases globally. TB kills 1.7 million people worldwide each year, and 9.2 million people develop active disease, according to estimates from the World Health Organization. If some version of this technique proves

safe and effective, it would give doctors a way to get rapid feedback on disease activity and drug response. “This award is not only a tremendous honor, but it comes at a time when research funding is critically needed yet not that easy to get,” Jain said. “It will help us continue our research.” An assistant professor of pediatrics since 2006 in the Division of Pediatric Infectious Diseases, Jain is currently director of the Center for Infection and Inflammation Imaging at Johns Hopkins and a member the Center for TB Research. This year’s 73 Pioneer and New Innovator awards, which total $348 million, are the largest number in the program’s history, according to the NIH. “The appeal of the Pioneer, New Innovator and now the T-R01 programs is that investigators are encouraged to challenge the status quo with innovative ideas while being given the necessary resources to test them,” said NIH Director Francis S. Collins. “The fact that we continue to receive such strong proposals for funding through the programs reflects the wealth of creative ideas in science today.”

Study: Johns Hopkins researchers ID brain-protecting protein By Maryalice Yakutchik

Johns Hopkins Medicine

ohns Hopkins researchers have discovered a novel protein that can protect brain cells by interrupting a naturally occurring “stress cascade” resulting in cell death. The scientists say that drugs mimicking the protein, nicknamed GOSPEL, have the potential to protect brain cells against a range of neurodegenerative conditions, including stroke and Alzheimer’s and Huntington’s diseases. The study was reported in the July 16 issue of the journal Neuron. “This work has potentially broad clinical implications,” said senior author Akira Sawa, associate professor and director of the Molecular Psychiatry Program in the School of Medicine. Sawa and his team, in collaboration with neuroscientist Solomon Snyder and his team, conducted experiments showing that

GOSPEL competes with a second protein when it tries to latch onto glyceraldehyde3-phosphate dehydrogenase, or GAPDH, a multifunctional molecule. By binding to GAPDH, GOSPEL both prevents the cell death cascade and offers brain cells protection against potentially toxic agents. Sawa has spent more than a decade studying GAPDH activity and its role in so-called oxidative-stress-induced cellular responses, including programmed cell death. That cascading process begins when various stressors such as injury or disease activate a complex enzyme called nitric oxide synthase, which then forms nitric oxide, a chemical that transmits signals between nerves but also is toxic to cells. Excess levels of nitric oxide cause GAPDH to undergo a chemical modification called S-nitrosylation that in turn lets it bind to another protein, Siah1. The combined GAPDH-Siah1 molecules then move into a cell’s nucleus, hijack key portions of its DNA and set off a chain of reactions leading to cell death.

In the currently reported study, the researchers analyzed tissue samples from rats to identify the DNA coding for GOSPEL (which stands for GAPDH’s competitor of Siah Protein Enhances Life) and found that the protein exists in tissues in the brain, heart, lung and skeletal muscle, though it is most widely expressed in neurons in the central nervous system. A series of laboratory experiments in mouse brain tissue found the following: S-nitrosylation is necessary to enable GOSPEL to bind to GAPDH, GOSPEL competes with Siah for GAPDH binding, GOSPEL prevents GAPDH from slipping into the cell nucleus, and GOSPEL diminishes brain cell damage by preventing the binding of GAPDH and Siah. To determine whether GOSPEL’s neuroprotective actions were evident in live mice, the scientists used a benign virus to deliver into the animals’ brains either GOSPEL or an altered version of GOSPEL lacking the property to bind with GAPDH. They then injected a neurotransmitter,

NMDA, to induce and simulate other kinds of brain damage. The researchers found that NMDA-induced lesions in the brains of mice injected with GOSPEL were about 30 percent smaller than in those injected with the altered GOSPEL, showing that the neuroprotective influence of GOSPEL related to its ability to bind to GAPDH. The GOSPEL molecule was first available in the database of the Human Genome Project, Sawa says, but until now was designated as a genetic compound with no known properties. The work was supported by grants from the U.S. Public Health Service, the Stanley Medical Research Institute, NARSAD (the National Alliance for Research on Schizophrenia and Depression), the CHDI Foundation and the S-R Foundation. Co-authors were Nilkantha Sen, Makoto R. Hara, Abdullah Shafique Ahmed, Matthew B. Cascio, Atsushi Kamiya, Jeffrey T. Ehmsen, Nishant Aggrawal, Lynda Hester, Sylvain Dore, and Snyder.

4 THE GAZETTE • September 28, 2009

Fitzgerald Continued from page 1 Cambridge Arms Apartments, which today is Wolman Hall, a university-owned undergraduate residence building. Fitzgerald called Baltimore home from 1932 to 1937, and although the prime reason he moved here is quite cheerless— his wife’s mental illness—Fitzgerald forged strong ties to the city. Even before he moved to Baltimore, Fitzgerald felt a kinship with the place, as his family was from Maryland and it was famously where his relative and namesake Francis Scott Key wrote “The Star-Spangled Banner.” In a sense, one of Baltimore’s favorite adopted sons returns this week, as Charm City will host the 10th International F. Scott Fitzgerald Society Conference. The four-day event, sponsored by the F. Scott Fitzgerald Society, will feature several Johns Hopkins University professors and locations. On Wednesday, Sept. 30, the first day of the conference, the George Peabody Library in Mount Vernon will host a reception and talk by Sharon Hamilton, a lecturer at Georgetown University, about H.L Mencken, Fitzgerald and The Smart Set magazine. As editor of The Smart Set, Mencken was the first to publish a Fitzgerald story, “Babes in the Woods,” in 1919. The Johns Hopkins University Press, the F. Scott Fitzgerald Society and the Friends of the Sheridan Libraries will sponsor the talk and reception, to be held from 6 to 8 p.m. It will highlight the new Peabody Library exhibit A View of the Parade: H.L. Mencken and American Magazines. Fitzgerald long admired Mencken, and the two would later become close friends. It was Mencken who referred Fitzgerald to Adolf Meyer, chief of Psychiatry at the Johns Hopkins School of Medicine, when Fitzgerald’s wife, Zelda, suffered her second nervous breakdown. The Fitzgeralds moved to Baltimore so

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that Zelda, diagnosed with schizophrenia, could receive treatment at The Johns Hopkins Hospital’s Henry Phipps Psychiatric Clinic, where Meyer had been director from its inception in 1913. During her stay at the Phipps Clinic, Zelda wrote her semi-autobiographical novel, Save Me the Waltz, and after her release, a play called Scandalabra. While there, she also made many paintings and drawings, seven of which were donated to the English Department in March 1971 by Mr. and Mrs. Sewell Weech. Six of the drawings, which now hang at Evergreen Museum & Library, will be on view in the museum’s Reading Room during a conference-related reception being held there from 5 to 7 p.m. on Thursday. The event, sponsored by the F. Scott Fitzgerald Society and The Hopkins Review literary journal, will feature a reading of Fitzgerald’s work by Richard A. Davison, professor emeritus at the University of Delaware. John Irwin, Decker Professor in the Humanities at Johns Hopkins and a member of the F. Scott Fitzgerald Society, has taught a course on Faulkner, Fitzgerald and Hemingway at the Writing Seminars for the past 30 years. Irwin regards Fitzgerald as one of 20th-century America’s best fiction writers. Recently, Fitzgerald returned to the public eye with the release of The Curious Case of Benjamin Button, a film based on one of his short stories, which the author set in Baltimore. “Fitzgerald’s impact is immense. Consider that just about every junior high or high school student has read The Great Gatsby before coming to college,” Irwin said. “Fitzgerald came back with a real bang in the 1950s and never left.” Irwin describes both the 1925 Gatsby and Tender Is the Night, which was published in 1934, as masterpieces. “The Last Tycoon would have been a third masterpiece if he lived to finish it,” Irwin said. “The Great Gatsby is great in so many different ways. It’s a short, self-contained book that is almost perfect. You can’t imagine changing any word in it. Tender Is the Night is a bigger book that tackles larger themes and has the power to break your heart.”

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Tender Is the Night’s main character, psychiatrist Richard “Dick” Diver, is depicted as a graduate of Johns Hopkins Medical School. In the book, Fitzgerald writes of the young Diver as a “tornado who hurried through the old red buildings of Hopkins” and makes reference to the Jesus statue located in the rotunda of the Billings Administration Building. The statue will be among the stops at The Johns Hopkins Hospital during a three-hour tour on Thursday of Fitzgerald’s Baltimore led by Margaret Galambos, a former staff member of the Johns Hopkins University Press and a member of the Fitzgerald Society, and others. The tour will make stops at Wolman Hall, Mencken’s house on Holland Street, the Fitzgeralds’ house on Park Avenue in Bolton Hill, the Francis Scott Key monument in Bolton Hill, the Belvedere Hotel in Mount Vernon and other spots. Mencken and Fitzgerald often socialized at the Belvedere’s Owl Bar. The Belvedere was also the location of the sweet 16 party for the Fitzgeralds’ only child, Frances Scott “Scottie” Fitzgerald. Galambos said that by various accounts Fitzgerald loved many elements of his life in Baltimore. “He was a Key and proud of it, and always talked about his ancestors,” she said. “And he and Mencken were very close. They talked and socialized often.” Fitzgerald scholar John D. Rockefeller V, a part-time lecturer with the School of Arts and Sciences, said that Fitzgerald’s life in Baltimore and his attempts to salvage his wife’s sanity had a deep influence on the author’s later writings. Rockefeller said that Fitzgerald went so far as to “plagiarize” some of his wife’s “unbalanced” letters and weave them into his stories and novels. Rockefeller

specifically delves into this in his course called Fitzgerald’s Literature of Madness and Critique of Progressivism. Rockefeller will present at the conference a paper focused on how Fitzgerald conceived both The Beautiful and the Damned and Tender Is the Night as fulfilling Herbert Croly’s call in The Promise of American Life for a more progressive America—a call that Fitzgerald lamented progressives themselves ignored when they embraced the cause of Prohibition. He said that the conference, which is open to the public, is a good opportunity to reflect on a great writer. “Baltimore should be as proud of Fitzgerald as it is of Poe,” said Rockefeller, who has taught several courses on Fitzgerald. “Tender Is the Night was written here, which is a brilliant novel, a tour de force. Fitzgerald’s novels are often admired for their lyrical prose but seldom esteemed for their intellectual vigor. Fitzgerald lived with the tag of being a drunken, gifted writer, but he was a deep thinker—just as smart as Faulkner.” On Friday, the conference will host a buffet dinner at the Belvedere Hotel featuring two other Johns Hopkins faculty members: John Barth, professor emeritus, and Alice McDermott, the Richard A. Macksey Professor of the Humanities. Barth and McDermott, both of the Writing Seminars, will read favorite passages from Fitzgerald’s works and will speak briefly about his writing. The International F. Scott Fitzgerald Society meets every two years at its conference, and this is the first time it will be held in Baltimore. G To register for conference events and a full schedule, go to www.fscottfitzgeraldsociety.org.

Flu update: Vaccines, university sick-leave policies

his year’s flu season arrives in two guises: the seasonal and H1N1 varieties. In an e-mail last week regarding their status at Johns Hopkins, Charlene Hayes, vice president for human resources, reminded faculty and staff that the university has already begun vaccinating employees against seasonal flu. “Public health officials say it is still important to get this protection, since seasonal flu likely will surface more frequently as the weather turns cold,” she said. Announcements about vaccination sessions are being made at individual campuses, and information is also available at www.hopkinsmedicine.org/hse/ occupational_health/flu_campaign.html. Regarding the just-approved H1N1 vaccine, Hayes said it would be offered to employees as soon as it becomes available to the university, probably late this year and in relatively small allotments at first, and that the vaccination sessions will be publicized widely. The university, she said, will follow national and state guidelines about giving the vaccine first to certain priority or at-risk groups, such as patient-care staff, pregnant women and people with certain chronic diseases. Normal sick and vacation utilization

policies apply to any absence due to H1N1, Hayes said, and are as follows: • Employees unable to report to work as a result of personal or family illness are expected to cover those absences with vacation or sick leave. Any employee without leave accrued will be allowed time off without pay. • Managers and supervisors are expected to be flexible with the use of work-at-home options, sick leave and vacation when employees must stay home with sick children or other family members. Absences related to an employee’s own H1N1 illness, or to the care of a family member with H1N1, will not count against the employee in areas where there are strict or no-fault attendance policies. • As is always the case, any employee who abuses sick leave by falsifying reasons for an absence may be subject to disciplinary action, up to and including termination. Employees are reminded that if they develop flulike symptoms while at work, they may go to the Occupational Health offices at Wyman Park or East Baltimore, or call them at 410-516-0450 or 410-9556211.

School-family-community success stories profiled

he National Network of Partnership Schools at Johns Hopkins has published Promising Partnership Practices 2009, a collection of more than 110 best practices chosen from schools, districts and organizations across the country. The activities are used to improve reading, math, science, attendance and multicultural understanding, and to create a family-friendly school environment. Among them are math and reading nights, science and social studies projects, back-to-school events, and health and safety programs. “This year’s collection is especially strong,” said Joyce Epstein, director of NNPS. “The innovative, goal-oriented activities include

several designed to increase the involvement of dads and father figures and to involve families from diverse cultural and linguistic backgrounds.” Promising Partnership Practices 2009 is available online at www.partnershipschools .org in the section “Success Stories,” along with more than 700 practices from previous publications. The NNPS guides schools, districts, states and organizations across the country in developing effective programs of family and community involvement. Members share their best practices to help others improve their programs.

September 28, 2009 • THE GAZETTE A R R A

R E S E A R C H

This is the first in an occasional series on Johns Hopkins research funded by the American Recovery and Revitalization Act of 2009. If you have a study you would like to be considered for inclusion, contact Lisa De Nike at lde@jhu.edu. By Lisa De Nike

Homewood

ats do it; so do monkeys, pigeons and people: They quickly and intuitively size up the number of objects in their environment. It’s this inborn “approximate number system” that enables, for instance, a skittering rodent to quickly ascertain which garbage heap offers the most delectable food waste, or helps an in-a-rush motorist decide which tollbooth lane will offer the quickest passage. Though research indicates that we are born with this sense (scientists contend that it probably evolved very early, to help animals and our human ancestors survive in the wild), little is known about how number sense changes and develops throughout the human life cycle and how it affects the way people comprehend mathematics. That’s why a team of psychologists at The Johns Hopkins University’s Krieger School of Arts and Sciences is using a $1.6 million National Institutes of Health grant, underwritten in part by the federal stimulus package, to finance a multifaceted study aimed at decoding some of the mysteries of the human approximate number system, or ANS. They want to find out, for instance, everything from how it changes from infancy through adulthood to the impact that number sense acuity has on later success (or failure) in academic and higher order mathematics. Lisa Feigenson is teaming up with her research partner and husband, Justin Halberda, both assistant professors in the Department of Psychological and Brain Sciences, on the project. “What we are setting out to do is to examine numerical ability in infants, young children and adults, and to document how it changes over the course of their development,” said Feigenson, who also co-directs the Homewood campus–based Laboratory for Childhood Development, where she and Halberda conduct research into everything from how infants keep track of objects to whether babies and children are logical and rational when making decisions (they seem to be). The team came to Johns Hopkins from

ARRA Continued from page 1 in service of society by expanding their research programs with ARRA funds to enhance their rate of discovery and the knowledge-based economy in Baltimore and Maryland.” Elise Weerts, associate professor of behavioral biology in the School of Medicine, is among Johns Hopkins faculty members who have been awarded grant money. In an effort to better understand why some people are more susceptible to abusing alcohol, Weerts will use brain-imaging techniques to explore whether individual differences in the brain’s opiate receptor system contribute to future risk of alcohol problems. Justin Hanes, a professor of chemical and biomolecular engineering with the Whiting School of Engineering and the Institute for NanoBioTechnology, received recovery funds to develop biodegradable polymercoated nanoparticles that can penetrate the human cervix’s tough mucus barrier to deliver lifesaving drugs with a minimum of side effects. This approach would provide an alternative to systemic chemotherapy,

Harvard University in summer 2004 to establish the laboratory, a brightly painted, toy-strewn, cheery facility where children ages 3 months to 6 years participate in a variety of studies aimed at shining a light on human development’s many aspects. Though Feigenson specializes in the study of how infants keep track of and remember objects, and Halberda primarily studies logical reasoning and language, this grant merges the partners’ research interests into one large project that will delve into various aspects of the human approximate number system. For instance, though we know that babies, children and adults can all rapidly estimate, without counting, the number of items put before them, an understanding of how this ability changes over time is lacking, Halberda says. “And we know even less about how this untrained ability interacts with, and even possibly affects, the formal math that we later learn in school. One of our aims is to track individual children over a period of several years so that we can understand how their approximate number system develops, both prior to and during exposure to school mathematics,” he said. Though Feigenson and Halberda hope to shed light on how the approximate number system changes from infancy through young adulthood, one of the other key questions they aim to answer is whether individual differences in numerical acuity will accurately predict whether children will end up being good math students. Last year, the team published in the journal Nature a study tentatively linking number sense to math achievement in school. The researchers found that knowing how precisely a high school freshman can estimate the number of objects in a group reflects how well he has done in math as far back as kindergarten. “We learned that good number sense at age 14 correlates with higher scores on standardized math tests throughout a child’s life, and weaker number sense at 14 predicts lower scores on the same tests,” Halberda said. “What this seems to indicate is that the very basic number sense we humans share with animals has some impact on the formal mathematics we learn in school, and these things may inform and interact with each other throughout our lives.”

which often doesn’t work because early cervical tumors are not fed by many blood vessels, and the concentrations of the drug that come through those vessels are often inadequate to affect the tumors. Jennifer Elisseeff, an associate professor in the Whiting School of Engineering’s Department of Biomedical Engineering, is using her stimulus-funded award to develop components of a tissue-engineered form of “cartilage” that promises relief for the millions of Americans with ailing joints due to age, injury or illnesses such as osteoarthritis. These components will include composites of biological and synthetic polymers that will interact with native cartilage tissues in the damaged joint to enhance their regeneration. This spring, Johns Hopkins held a job fair seeking candidates for the specialized science and administrative jobs that were expected to open up, thanks to extra research funding made possible by ARRA funds. As a result of that event, it has begun to hire people for these positions, not only in laboratories but also in budget, information technology and research administration jobs. Johns Hopkins has been the leading U.S. academic institution in total research and development spending for 29 years in a row. G

W IL L KIR K / H OM EW OOD PH OT O.JH U .ED U

Using stimulus dollars to decode human number sense

In the Homewood-based Laboratory for Child Development, psychologists Lisa Feigenson and Justin Halberda are studying how infants and young children who have not yet learned to formally count understand numbers.

Halberda says that he is intrigued by numbers because of his interest in logical and scientific thinking. Feigenson has a different reason. “Numerical knowledge is a case study for understanding human thinking in general,” she said. “Understanding how we perceive and reason about the world around us, whether in terms of numerical quantities, or in terms of social entities, or in terms of the physical world, begins to tell us what it means to be a human thinker.” Feigenson says that studying the ANS is important because it provides an example of an ability that is innate—present in animals and humans from birth, without training—but that in humans is also significantly shaped by experiences that she calls “uniquely human.” “It’s only humans, or a small subset of humans, who ever learn to solve quadratic equations or do long division, for that matter,” she said. “The basis for these abilities may be something evolutionarily ancient that we share with rats and monkeys. Because of this, the ANS is an excellent opportunity to study the interaction of knowledge that is inborn with knowledge that is the product of formal instruction.” In addition to contributing to basic cognitive science knowledge, the team’s research results may ultimately benefit people with dyscalculia, a learning disability that afflicts about one in every 15 people and brings with it innate difficulty in comprehending mathematics and other number-based skills. “Our project may have important repercussions not only for children with mathspecific cognitive deficits but also for studySPECTRUM 1-16 GAZETTE 8-08:Layout 2

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ing impairments in understanding numbers, such as happens after people suffer a stroke or other illness,” Feigenson said. The team’s study is one of more than 250 stimulus-funded research grants totaling more than $114 million that Johns Hopkins has garnered since Congress passed the American Recovery and Revitalization Act of 2009 (informally known by the acronym ARRA), bestowing the National Institutes of Health and the National Science Foundation with $12.4 billion in extra money to underwrite research grants by September 2010. The stimulus package—which provided $550 billion in new spending, including the above grants, and $275 billion in tax relief—is part of President Barack Obama’s plan to kick-start a stagnant economy by doling out dollars for transportation projects, infrastructure building, the development of new energy sources and job creation, and by financing research that will benefit humankind.

Related Web sites Lisa Feigenson:

www.psy.jhu/fs/faculty/feigenson .htm

Justin Halberda’s Web site:

www.psy.jhu/fs/faculty/halberda .htm

Laboratory for Child Development:

www.psy.jhu.edu/ ~labforchilddevelopment

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6 THE GAZETTE • September 28, 2009

SCHOOLS’ OPEN HOUSES

Educating today’s young women for the possibilities of tomorrow.

Garrison Forest School: Where hands-on learning gets down to business. GFS and “Summer$tock” Investment Camp students track a stock pick.

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Saturday, Nov. 7, 2009 10:00 AM – 1:00 PM

Open House 11300 Falls Road Brooklandville, MD 21022 410-252-3366 • www.maryvale.com

Celebrating a Catholic Tradition of Excellence for more than 60 years.

Coed, Age 2 through Kindergarten Girls, Pre-First through Grade 12 • October 25 at 2:30 pm

www.gfs.org • 410.559.3111 National, Inter national, and Regional Residential Program

Independent School Fair Sunday, October 4, 2009 3:00 p.m. to 5:00 p.m. Glass Pavilion, Levering Hall Johns Hopkins University

Participating Schools*

Annapolis Area Christian School Baltimore Lutheran School The Boys’ Latin School of Maryland The Bryn Mawr School Calvert School Cambridge School Friends School of Baltimore Garrison Forest School Gilman School Glenelg Country School Indian Creek School Institute of Notre Dame The Jemicy School Loyola Blakefield Maryvale Preparatory School McDonogh School

Mercy High School The Montessori School Notre Dame Preparatory School Oldfields School The Park School of Baltimore Roland Park Country School Saint James School St. Albans School St. Ignatius Loyola Academy St. James Academy St. Paul’s School St. Paul’s School for Girls St. Timothy’s School Waldorf School of Baltimore West Nottingham Academy

Propelled by possibility.

* AIMS member schools are committed to the principle of non-discrimination on the basis of race, color, national and/or ethnic origin.

Please join us!

• Representatives from participating schools will be on hand to answer questions • Brochures and information materials will be available • Adults and prospective students are welcome • Free admission • Small fee to park

Sponsored by

Association of Independent Maryland Schools (AIMS) and Baltimore Educational Scholarship Trust (BEST) The Association of Independent Maryland Schools (AIMS), organized in 1967, is an association of more than 112 independent, college-preparatory schools in Maryland and D.C., representing more than 44,000 students.

Directions: From I-695, take I-83 South to Coldspring Lane East. Turn right at Roland Avenue. At next traffic light, the road splits. Stay in the left lane which becomes University Parkway. At the fifth traffic light, turn right onto Charles Street. (stay in right lane). Turn right onto Art Museum Drive. Just past the Baltimore Museum of Art, turn right onto Wyman Park Drive. Signs will be posted to direct you. AIMS • (410) 761-3700 or (301) 858-6311 • www.aimsmd.org • info@aimsmd.org

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Open House for parents and students entering grades 6 through 12: Sunday, October 18 at 2 p.m.

For 225 years, Friends School has been teaching boys and girls to lead their lives with wisdom, integrity and confidence.

Group Tours for parents of children entering Pre-K– Grade 12. To schedule, call 410.649.3211 or admission@friendsbalt.org.

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September 28, 2009 • THE GAZETTE

MESSENGER spacecraft prepares for final pass by Mercury B y P a u l e tt e C a m pb e ll

Applied Physics Laboratory

n Wednesday, Sept. 29, the MESSENGER spacecraft will fly by Mercury for the third and final time, passing 141.7 miles above the planet’s rocky surface for a final gravity assist that will enable it to enter orbit about Mercury in 2011. With more than 90 percent of the planet’s surface already imaged, the team will turn its instruments during this flyby to specific features to uncover more information about the planet closest to the sun. “The first two flybys of Mercury revealed nearly half of the planet in detail for the first time,” said MESSENGER principal investigator Sean Solomon, of the Carnegie Institution of Washington. “During this third encounter, the MESSENGER camera will again image areas never before seen at close range, and we will obtain color images of other regions at resolutions superior to those of previous observations. Our other instruments will target interesting areas of the surface, atmosphere and magnetosphere for detailed measurements designed to address questions raised by observations made during the earlier flybys.” Depending on the activity of the sun, Solomon said, MESSENGER might also view yet another distinct snapshot of how the planet interacts with conditions in interplanetary space driven by the behavior of our nearest star. The first two flybys provided an unprecedented glimpse into the structure of the planet’s tenuous exosphere and the processes behind it. During this encounter, the Mercury Atmospheric and Surface Composition Spectrometer, or MASCS, will again make high spectral– and high spatial– resolution measurements of Mercury’s exosphere. “Targeted scans of the planet’s cometlike tail by the MASCS Ultraviolet and Visible Spectrometer will permit a search for temporal variability in both the sodium and calcium components,” said MASCS instrument scientist Noam Izenberg, of Johns Hopkins’ Applied Physics Laboratory. “In addition, we will target the north and south polar regions for detailed observations of those species, and we will look for several new exospheric species.” The Mercury Dual Imaging System, or MDIS, will capture 1,559 pictures of the planet. “Using all 11 filters of the wide-angle camera, we are going to collect high-resolution color images of scientifically interesting targets that we identified from the

MESSENGER’s two flybys of Mercury in 2008 greatly increased the portion of the planet’s surface that has been imaged by spacecraft, from approximately 45 percent coverage obtained by Mariner 10 to about 90 percent coverage following the second flyby. This significant increase is enabling global studies of Mercury’s surface for the first time. The third flyby takes place this week.

second flyby, and at the same time MASCS will observe those same targets,” said APL’s Ralph McNutt, MESSENGER project scientist. As MESSENGER approaches Mercury, MDIS’ narrow-angle camera will capture images of previously unseen terrain. Later, as the spacecraft departs, the camera will take high-resolution images of the southern hemisphere that will be used to create a mosaic to complement the high-resolution northern hemisphere mosaic obtained during the second Mercury flyby. Images captured eight days before and 21 days after the probe’s closest approach to Mercury will allow MESSENGER scientists to create detailed phase curves of Mercury at multiple wavelengths, and searches will be conducted for possible satellites of Mercury as small as 100 meters in diameter. Determining the composition of Mercury’s surface is a major goal of the orbital phase of the mission, and during this flyby the instruments focused on compositional measurements will have a third opportunity to observe Mercury. The MASCS sensors—both UVVS and the Visible and Infrared Spectrograph— will spend about 30 seconds on each of 11 targets, two at locations also targeted for photometry, focusing on end-member compositional characteristics identified during the second flyby. The X-Ray Spectrometer will once again look for X-ray fluorescence from surface elements, depending on the level of solar activity, and the Gamma-Ray

Spectrometer will acquire more counting data from approximately the same region that it surveyed during the second flyby. The Neutron Spectrometer will use two spacecraft maneuvers to provide better Doppler filtering of encountered neutron fluxes, including a 180-degree spacecraft roll on the nightside (inbound) and a 45-degree roll on the dayside (outbound). The nightside maneuver will provide more information on the composition on the side of the planet away from that sampled during the first flyby, and the combination of dayside and nightside measurements will enable a test of the influence of planetary surface temperature on the thermal neutron fluxes, data important for properly interpreting the neutron fluxes to be measured during the orbital phase of the mission. MESSENGER’s third Mercury flyby will provide more data on the correlation between high-resolution topography and high-resolution images of Mercury. The Mercury Laser Altimeter will range to Mercury’s surface and make a topographic profile along the instrument ground track. A shift in the longitude of closest approach by 17 degrees to the west and 3 degrees north from the position of closest approach for the second flyby will allow the data from the third flyby to augment and complement those from the second. In addition, the slower flyby speed (approximately 1.5 kilometers per second slower relative to the center of Mercury) will keep the trajectory closer to the planet longer. “The data we gather will provide additional topography of surface features on Mercury for our ongoing studies of the morphology of craters and tectonic structures, such as thrust faults,” said MLA instrument scientist Olivier Barnouin-Jha, of APL. “It will also extend our equatorial view of Mercury’s global shape and allow us to confirm the discovery made during the first and second flyby of MESSENGER that Mercury’s

equatorial region possesses a slightly elliptical shape.” The third Mercury encounter could reveal surprises about the planet’s magnetic field, says MESSENGER deputy project scientist Brian Anderson, of APL. “The first two flybys took the spacecraft over opposite sides of the planet—over the eastern hemisphere in January 2008 and the western side in October 2008,” Anderson said. “The third flyby will take it again over the planet’s western hemisphere, and the observations will be used to refine the estimate of the planet’s internal magnetic field.” Anderson says that this flyby is the last opportunity to survey the magnetotail and magnetopause regions in the equatorial plane. “The contrast in the system’s structure under different solar wind conditions already observed make it likely that the third flyby will yield new insights and perhaps more surprises regarding the dynamics of this smallest and most highly variable of the solar system’s planetary magnetospheres,” he said. As with the previous two flybys, the magnetometer will record the magnetic field at the highest available observation rate of 20 vector magnetic field samples per second for a period of 12 hours centered on the time of closest approach. “This observing plan guarantees the highest possible science return from the encounter and will provide key observations to guide the magnetic field investigation plan for the prime orbital phase of the mission,” Anderson says. ”This flyby will not only be our last close look at the equatorial regions of Mercury; it is our final planetary gravity assist, and it will be important for the entire encounter to be executed as planned,” Solomon said. “As enticing as these flybys have been for discovering some of Mercury’s secrets, they are the hors d’oeurves to the mission’s main course: observing Mercury from orbit for an entire year.”

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Grades 5-8 1:00 p.m. Sunday, October 18 Grades 9-12 3:30 p.m. Sunday, October 18

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8 THE GAZETTE • September 28, 2009

Mild exercise in ICU reduces bad effects of prolonged bed rest B y D av i d M a r c h

Johns Hopkins Medicine

ritical care experts at Johns Hopkins are reporting initial success in boosting recovery and combating muscle wasting among critically ill, mostly bed-bound patients using any one of a trio of mild physical therapy exercises during their stays in the intensive care unit. “ICU-related muscle weakness is the No. 1 factor in prolonging a patient’s recovery and delaying their return to a normal life, including work and recreational activities,” said critical care specialist Dale Needham, the senior researcher involved in producing the report, published in the journal Critical Care Medicine online Sept. 21. “Our ICU patients are telling us that they want to be awake and moving. Gone are the days when we should only think of critically ill patients on complete bed rest,” said Needham, whose 2008 publication in the Journal of the American Medical Association reported that a majority of ICU patients experienced prolonged fatigue and delayed recovery after bed rest. In the new report, Needham and colleagues describe muscle-strengthening exercises that can be introduced early into the treatment plans of critically ill patients. Needham’s team, including two physical therapists, has used these exercises in treating more than 400 patients in The Johns Hopkins Hospital’s medical ICU in the last year. Although longer follow-up is needed, Needham and his team say that their early approach to having patients exercise while in the ICU is showing signs of success, with

patients leaving the hospital sooner, stronger and happier. Some of the ICU patients are undergoing electrical stimulation to strengthen leg muscles, getting up to walk around the ICU and even cycling while lying down by using a specially designed device attached to the end of the bed. Experts say that plenty of data suggest that long periods of bed rest, even episodes lasting a few days, can lead to significant muscle weakness. In some studies, patients have lost as much as 5 percent per week of leg-muscle mass. Needham, an assistant professor at the Johns Hopkins University School of Medicine, says that developing physical therapy regimens for ICU patients requires good planning because most of the patients are on mechanical ventilators, and some are also sedated while undergoing treatment. In neuromuscular electrical stimulation, a technique used to hasten recovery in injured athletes, electrodes are placed on the skin over three major muscle groups in each leg, with low-voltage electrical impulses inducing muscle contractions that may mimic mild exercise. Three patients at The Johns Hopkins Hospital have used the electrical pads for half-hour, twice-daily exercise sessions as part of the devices’ clinical testing. Needham says that the team is still tracking recovery times, but he notes that studies in patients who were not critically ill have demonstrated that the technique keeps muscles from weakening. For their walks, patients remain connected to their ventilators, heart monitors and other equipment while using a standard walker. A nurse and physical and respiratory therapists accompany and monitor the patient, stopping for rest periods as needed.

Walking sessions, including rest breaks, usually last half an hour. The team has also developed, with help from Johns Hopkins biomedical engineering students, a special walker called the MOVER Aid, with a built-in seat for patients who need to sit and rest. The MOVER includes a wheeled pole to hold a ventilator and ICU monitoring equipment. The motorized stationary bicycle affixed to the ICU bed has been used by more than a dozen patients at JHH, some of them sedated. Patients peddle for as much as 20 minutes per day. Researchers in Europe, where the cycle ergometry device is made, recently compared a group of more than 30 ICU patients who used the cycle to a similar number who did not and found that at discharge from the hospital, trained patients had stronger leg muscles, and more were able to walk on their own. According to critical care expert Eddy Fan, an instructor at Johns Hopkins who collaborates on research with Needham, the long-term complications from stays in the ICU have come to light only as survival rates in critically ill patients have improved over the last 20 years. He says that many more people are now surviving after being admitted with acute respiratory distress syndrome, one of the most severe medical conditions in need of critical care support. “Bed rest often only compounds the problem and makes it worse,” said Fan, who has had a patient lose as much as 60 pounds as the result of bed rest during an ICU stay of several weeks. “Many patients are already weak when they arrive in the ICU, having been sick for a while, and having dropped weight as a result of poor appetite. So they

are often starting from a personal low point when they get here, and the lack of physical activity only hastens their decline,” he said. “Early physical therapy is helping us to fix this problem,” he said. “It really is changing the way we practice critical care medicine in the ICU.” Since the introduction of early mobility practices in the ICU, Fan points out, average stays in The Johns Hopkins Hospital’s medical ICU have dropped by as much as two days (more than 20 percent). Furthermore, Fan says, efforts to reduce sedative use and its associated delirium are also proving effective. Delirium and its associated hallucinations are known to occur in ICU patients who have been heavily sedated, prolonging their recovery. Needham says that his team’s next steps are to continue with long-term clinical tests of each technique, already under way at several U.S. hospitals, in which some critically ill patients are exercising heavily and others less so or not at all. The ultimate goal, the researchers say, is to determine if and by how much early mobility exercises improve quality of life. Funding support for the report and research was provided by The Johns Hopkins University and The Johns Hopkins Hospital. Johns Hopkins researcher Alex Truong also contributed to this report.

Related Web sites Dale Needham:

www.hopkinsmedicine.org/ pulmonary/faculty/division_ faculty/needham_dm.html

High school diploma alone isn’t the solution for livelihoods By Mary Maushard

CSOS

ecent graduates from Philadelphia’s public high schools had higher employment rates and higher annual earnings than their classmates who dropped out, but many of them still did not have incomes above the federal poverty line, according to a new study from the Everyone Graduates Center at Johns Hopkins. The report suggests that although it is essential to increase high school graduation rates, “without additional postsecondary education, the effect of a high school diploma on lives and livelihoods may be rather limited.” Untapped Potential: Early Labor Market Outcomes of Dropouts and Graduates from Philadelphia’s Public Schools, a study by Johns Hopkins researchers Ruth Curran Neild and Christopher Boccanfuso, looks at employment and earnings in Pennsylvania’s formal economy for students in the city’s classes of 2000–2005. The report shows that only 35 percent of the dropouts from the classes of 2000–2005 had any earnings in Pennsylvania in 2006, compared to almost half the graduates. “For those dropouts who were employed, work was typically episodic and annual incomes low,” the study said. “The average employed dropout worked just 25 weeks during the year, earning just more than $9,000.” Those with diplomas averaged approximately $12,000 during 2006. Both dropouts and graduates with no postsecondary education were most likely to be employed in restaurants, security and janitorial services, and institutions that provide care for the elderly, ill and disabled. Despite the importance to the city of knowing how its recent graduates and dropouts fare in the labor market, it is difficult to access these data, the researchers said. This new study draws on a unique data set that merges student academic records from the School District of Philadelphia and quarterly

data on employment and earnings kept by the Pennsylvania Department of Labor and Industry. The report was prepared for Project U-Turn, a citywide campaign to resolve Philadelphia’s high school dropout crisis. Untapped Potential reports on the same cohorts of students described in Unfulfilled Promise, a 2006 report on high school graduation rates in Philadelphia issued by Johns Hopkins and Project U-Turn. This new study provides two views of labor market outcomes: a description of employment and earnings in 2006, the most current year for which data is available, and an examination of the work experiences of the class of 2000 over multiple years. The report also provides detailed data on employment and earnings by race/ethnicity and gender. Among dropouts, AfricanAmerican and white females were most likely to be employed in Pennsylvania’s formal economy. Least likely were Asian males and females, but these groups had the highest mean earnings. As students move into early adulthood, the earnings differential by education increases. High school graduates do experience greater earnings growth than dropouts, but the upward slope is much steeper for those with at least some postsecondary education. Further, six years after their anticipated high school graduation date (June 2000), employed dropouts were still weakly attached to the formal labor market, working an average of 26 weeks. “Untapped Potential illustrates that students in the School District of Philadelphia who did not progress to postsecondary education after high school were marginally more prepared than high school dropouts for Pennsylvania’s 21st-century labor market,” said study author Boccanfuso. “That the gap in annual earnings between individuals with postsecondary education and those without expanded over the six years studied demonstrates that the effects of education on earnings were both significant and long-lasting.”

Because of this, the report urges schools and communities to think seriously about not only keeping students on the path to graduation but also helping them make a successful transition into postsecondary training and the work world. The Everyone Graduates Center is located at Johns Hopkins’ Center for Social Organization of Schools. Project U-Turn is

a collaborative campaign to build understanding of Philadelphia’s dropout crisis and implement strategies to resolve it. The William Penn Foundation, one of several major supporters of Project U-Turn, funded this research. The full report is available at www .every1graduates.org/UntappedPotential/ index.html.

Disparities

parities are mainly a matter of genetics, we need to first identify a gene, polymorphism or gene mutation that exists in one race group and not others. And when that gene is found, we need to then demonstrate that that gene is also associated with diabetes,” LaVeist said. “On the other hand, there is overwhelming evidence that behavior, medical care and the environment are huge drivers of race differences in health. It seems more likely that the answer to health disparities will be found among these factors.” Researchers in this study found that within their sample of racially integrated communities without race differences in socioeconomic and environmental factors, prevalence estimates of diabetes are similar between African-Americans and whites. According to the study, “Previous research has demonstrated that when African-Americans and whites access similar health care facilities, their health care outcomes are more similar.” The study’s authors said that their findings support the need for future health disparities research and creative approaches to examining health disparities within samples that account for socioeconomic and social environmental factors. Additional authors of the study are Roland J. Thorpe Jr., Kelly M. Bower, Jessica E. Galarraga and Tiffany L. Gary-Webb. The study was supported by funding from the National Center on Minority Health and Health Disparities, a National Institutes of Health agency. G

Continued from page 1 and other related complications compared to whites. “While we often hear media reports of genes that account for race differences in health outcomes, genes are but one of many factors that lead to the major health conditions that account for most deaths in the United States,” said lead author Thomas LaVeist, director of the Hopkins Center for Health Disparities Solutions and a professor in the Johns Hopkins Bloomberg School of Public Health. Some researchers have speculated that disparities in diabetes prevalence are the result of genetic differences between race groups. However, LaVeist noted that those previous studies were based on national data gathered from African-Americans and whites who, for the most part, lived in separate communities with different levels of exposure to health risks. The EHDICSWB study accounts for racial differences in socioeconomic and environmental risk exposures to determine if the diabetes race disparity reported in national data is similar when black and white Americans live under comparable conditions. “I don’t mean to suggest that genetics plays no role in race differences in health, but before we can conclude that health dis-

September 28, 2009 • THE GAZETTE

Scientists find pace-setter for repair in badly damaged lungs B y D av i d M a r c h

Johns Hopkins Medicine

fter more than 50 experiments in mice, medical scientists at Johns Hopkins have mapped out the basic steps taken by a particular set of white blood cells in setting the pace of recovery after serious lung injury. The white blood cells are called regulatory T cells, or Tregs for short, and their best-known function is to keep the body’s immune system from attacking its own healthy tissues. “Our study results are the critical first leads in finding treatments for a clinical condition that until now has had none, despite its high mortality,” said pulmonologist Landon King, study senior investigator. “When a patient develops acute lung injury, we want the critical care medicine team to be able to do more than just stabilize the patient on a ventilator,” said King, director of Pulmonary and Critical Care Medicine at the School of Medicine. King says that the study opens the door to a new field in research and to development of drugs that either speed up the post-injury activation of Tregs, or supplement levels of Tregs in people who may be relatively lymphocyte-deficient from either lung disease or chemotherapy. Lymphocyte is the technical term for a type of white blood cell. Some 200,000 Americans suffer each year from some form of sudden acute lung injury, or ALI, in which inflammation has spread across both lungs, making breathing difficult and starving the body of much-needed oxygen. Among those affected are people with severe acute respiratory distress syndrome caused by infection, the most severe form of ALI; burn victims; people with chest injuries from car accidents; and cancer

patients who have had adverse reactions to donated platelets from blood transfusion. Almost all people with ALI require breathing assistance from mechanical ventilators, and nearly 75,000 die each year. The team of Johns Hopkins lung experts, whose study results are published in the Journal of Clinical Investigation online Sept. 21, says that its three-year investigation is believed to be the first to distinguish the role of the immune system in wound repair in the lung from its role immediately following injury and the inflammation that follows. The researchers add that the study is also the first lab and clinical analysis to show how the body’s built-in system of naturally occurring Tregs can be sped up or slowed down, either aiding or hindering healing in severely damaged lung tissue. Spurred by the lack of treatment options, King and his team started to track and map out the biological steps involved in ALI recovery with an experiment in mice that were already serving as a lab model for lung injury. As part of the lab model, mice inhale a bacterial substance known to critically injure both lungs within 24 hours, with inflammation peaking, on average, after four days. In mice that survive, the average recovery time is 10 days. Researchers had long assumed that an initial spike in blood lymphocyte levels deep inside lung tissue cavities—a condition that occurs in mice as well as in humans—was the immune system’s first response to inflammation from injury. But the Johns Hopkins scientists were surprised to find a higher death rate in mice that had been genetically modified to be lymphocyte-deficient, at 40 percent, while the death rate in mice with lymphocytes was just 10 percent. After determining that lymphocytes were key to mice’s recovering from lung injury, the team set out to sort out the various roles,

Johns Hopkins epigenetic center receives $16.8 million NIH grant B y C h r i s t e n B r o wnl e e

Johns Hopkins Medicine

ohns Hopkins’ Center for the Epigenetics of Common Human Disease has been chosen as one of four recipients of a $45 million National Institutes of Health grant for Centers of Excellence to advance genomics research. The Johns Hopkins center will receive $16.8 million over five years. “We’re grateful for such generous support to continue our work in understanding how epigenetic control affects disease,” said the center’s director, Andrew Feinberg. Over the past five years, Feinberg, a professor of molecular medicine at the School of Medicine, has led a team of researchers at the center to study the epigenetic basis of common health problems, including cancer, autism and psychiatric illnesses. Epigenetics—or “above the genome”—refers to changes in genes other than the DNA sequence itself. The changes affect which genes are turned on or off and therefore which proteins are produced in cells. Feinberg says that because epigenetic variation

may be at least as great between individuals as variations in the DNA sequences themselves, understanding the epigenome may help explain how errors occur in normal development and how environmental factors lead to cancer, autism and other disorders. The center has already developed novel statistical and analytical tools to identify epigenetic modifications across the human genome. With the new funds, awarded by two NIH agencies—the National Human Genome Research Institute and the National Institute of Mental Health—Feinberg and his colleagues plan to refine these tools so that they can be used efficiently and costeffectively in large studies. The team will focus its efforts on studying the epigenetics of bipolar disorder, aging and autism. The scientists will also explore how other factors, such as a person’s genetic makeup, lifestyle choices and environmental exposures, interact with epigenetic factors to cause disease. The Johns Hopkins Center for the Epigenetics of Common Human Disease has been recognized since 2004 as one of NHGRI’s Centers for Excellence in Genomic Science.

Arts Innovation Grants available for Homewood faculty and students

he Arts Innovation Grants Program has announced that the next round of grants is now available for Homewood faculty and students. The initiative is designed to help faculty develop for-credit interdisciplinary courses in the arts—across departments, divisions or institutions—for Homewood undergraduates, and to help undergraduates create

new co-curricular activities in the arts or significantly increase the impact of existing ones within both the university and greater Baltimore communities. The grants are for Intersession and the spring and fall 2010 semesters. The deadline for submitting proposals is Friday, Oct. 16. For more information, go to www.library.jhu.edu/about/news/ announcements/artsinnovationgrants.html.

if any, played by specific lymphocytes by injecting injured mice with different types and combinations of the white blood cells, such as CD4 and CD8. Only transfusions of spleen cells rich in CD4 type T lymphocytes restored recovery time to normal. Further experiments led by Johns Hopkins pulmonologist Franco D’Alessio showed that blood levels of one subset of CD4 T lymphocytes, technically known as CD4+ CD25+ Foxp3+, or regulatory T cells, jumped proportionally in the lung spaces from the first day of injury before peaking at day seven and remaining high throughout recovery at day 10. This result proved to D’Alessio and colleagues that the spike was not just a response to injury but also part of the lung’s immediate and natural process of wound repair. When researchers removed Tregs from the damaged lungs in mice, leaving all other lymphocytes behind, lung resolution was again slowed by half. “T cells and the body’s active immune system play a crucial role in recovery from acute lung injury,” said D’Alessio, an instructor based at Johns Hopkins Bayview Medical Center. “It is by no means a passive process as previously thought.” To test the prospects of Tregs as a potential therapy, the scientific team doubled bacterial toxin exposures, increasing death rates to 50 percent in untreated mice. But mice injected with doses of a million Tregs within an hour of exposure had just a 10 percent death rate, with many showing signs of accelerated recovery after just six days. Similar doses of Tregs provided days after exposure also showed lowered death rates in mice with ALI. Additional lab testing showed that lungtissue levels of other immune system cells involved in inflammation, notably neutrophils and macrophages, also dropped in response to the influx of Tregs, providing further evidence for Tregs’ controlling the switch in the lung tissue “from an environ-

ment of inflammation to one of recovery.” “Our study should spark lung experts here and elsewhere to shift their research focus from nearly universal interest in the onset of acute lung injury to new mechanisms underlying resolution of lung injury,” said King, an associate professor at Johns Hopkins, where he holds the David Marine Professorship in Medicine. Initial results from lung tissue extracts from two people with an ALI, also reported in the latest study, showed that within 48 hours from injury Treg levels were 10 times normal. King says that his team’s next steps are to identify the process by which Tregs orchestrate the transition of the mouse immune response from injury to repair and isolating and analyzing Tregs over the whole recovery period in the lungs, with the goal of identifying further biological drug targets for speeding up recovery. He notes that experiments elsewhere are already under way using Tregs in treating people with leukemia in order to prevent rejection of bone marrow transplants. Funding for the study was provided by the National Heart, Lung and Blood Institute. Other Johns Hopkins researchers involved in the study were Kenji Tsushima, Neil Aggarwal, Erin West, Matthew Willett, Martin Britos, Matthew Pipeling, Roy Brower and John McDyer.

Related Web sites Landon King:

www.hopkinsmedicine.org/ pulmonary/faculty/division_ faculty/king_ls.html

‘Journal of Clinical Investigation’:

www.jci.org

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10 THE GAZETTE • September 28, 2009 P O S T I N G S

B U L L E T I N

Job Opportunities The Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

Notices Hippodrome Discounts — Discounts on show tickets for the 2009–2010 season at the Hippodrome Theatre/France-Merrick

S E P T .

Homewood

Office of Human Resources: Suite W600, Wyman Bldg., 410-516-8048 JOB#

POSITION

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POSITION

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School of Medicine

Office of Human Resources:

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POSITION

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22150 38064 37442 37260 38008 36886 37890 37901

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This is a partial listing of jobs currently available. A complete list with descriptions can be found on the Web at jobs.jhu.edu.

Woodcliffe Manor Apartments

S PA C I O U S

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R O L A N D PA R K

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2 8

B O A R D

Performing Arts Center are now available, with improvements in the online ordering process. The 2009–2010 discounted shows, closeout dates and ordering information are available at http://hr.jhu.edu/fsrp/Hippodrome .cfm.

–

O C T .

Calendar Continued from page 12 Trafficking of Ion Channels in Neuronal Dendrites,” a Cell Biology seminar with Hiroaki Misono, University of Maryland, Baltimore. Suite 2-200, 1830 Bldg. EB Thurs., Oct. 1, 4 p.m. “Spatio-temporal Models for EEG/MEG Source Estimation,” an Electrical and Computer Engineering seminar with Wanmei Ou, MIT. 110 Maryland. HW Thurs., Oct. 1, 4 p.m. “Frizzled Receptors in Development and Disease,” a Biology seminar with Jeremy Nathans, SoM. 100 Mudd. HW Thurs., Oct. 1, 4 p.m. “Scaling Great Ideas That Work: The Social Innovation Fund,” a Social Policy seminar with Robert Grimm. (See “In Brief,” p. 2.) Co-sponsored by the Institute for Policy Studies, Economics, and Health Policy and Management. 526 Wyman Park Bldg. HW

“Optimizing Group Sequential Designs That Allow Changes to the Population Sampled Based on Interim Data,” an Applied Mathematics and Statistics/Biostatistics joint seminar with Michael Rosenblum, SPH. 304 Whitehead. HW Thurs., Oct. 1, 4 p.m.

“Health-related Quality of Life, Visual Functioning and Depression in a Type 1 Diabetes Population: Wisconsin Epidemiologic Study of Diabetic Retinopathy,” an Epidemiology thesis defense seminar with Flavio Hirai. W2030 SPH. EB

Fri., Oct. 2, 10 a.m.

“Nearshore Tsunami Dynamics,” a CEAFM seminar with Patrick Lynett, Texas A&M. 110 Maryland. HW

Fri., Oct. 2, 11 a.m.

Fri., Oct. 2, noon. “Series Vaccination-induced Protection Against TB,” a special Molecular Microbiology and Immunology/Infectious Diseases seminar with Willem Hanekom, Burnet Institute/ University of Cape Town, South Africa/ South African Tuberculosis Vaccine Initiative, Cape Town. W1020 SPH. EB Mon., Oct. 5, 12:15 p.m. “Ovarian Histogenesis, Sex Determination and Regulation of Menopause,” a Carnegie Institution Embryology seminar with David Schlessinger, National Institute on Aging, IRP. Rose Auditorium, 3520 San Martin Drive. HW

SPECIAL EVENTS Sept. 28, 11 a.m. “Crisis: Shaping the Future,” an address on the

Mon.,

impact of the global economic crisis by Robert Zoellick, president, World Bank. (See “In Brief,” p. 2.) The speech will be live-streamed on www.sais-jhu .edu/news-and-events/zoellick. For more information or to RSVP, phone 202663-5644 or e-mail saispubaffairs@jhu .edu. Kenney Auditorium, Nitze Building. SAIS “Fitzgerald’s Smart Set Fiction: The Stories FSF wrote for The New Yorker of His Day,” a talk and reception with Sharon Hamilton, in conjunction with the exhibition A View of the Parade: H.L. Mencken and American Magazines. Also, a display and sale of JHU Press books by and about Mencken and Baltimore literary and cultural history. (See story, p. 1.) Sponsored by the JHU Press, the F. Scott Fitzgerald Society and the Friends of the JHU Libraries. George Peabody Library. Peabody

Wed., Sept. 30, 6 p.m.

Thurs., Oct. 1, 4 to 8 p.m.; Fri., Oct. 2, 9 a.m. to 6 p.m.; Sat., Oct. 3, 10 a.m. to 5 p.m.; and Sun., Oct. 4, 11 a.m. to 4 p.m. Johns Hopkins Best

Dressed Sale and Boutique, fundraiser for the Women’s Board of The Johns Hopkins Hospital. (See “In Brief,” p. 2.) Admission for the Oct. 1 pre-sale shopping, fashion consultations and light refreshments is $40 in advance, $45 at the door; admission is free for Oct. 2 through Oct. 4. On Oct. 4, most items are half price. Carriage House, Evergreen Museum & Library. The Chinese Mid-Autumn Festival Celebration Performance featuring dancing, singing, talk show, drama, piano, ballet, violin and erhu. Sponsored by the Chinese Students and Scholars Association and GRO. Shriver Hall. HW

Sat., Oct. 3, 7 p.m.

THEATER Fri., Oct. 2, and Sat., Oct. 3, 8 p.m.; Sun., Oct. 4, 3 p.m. Witness Theatre

presents Johns Hopkins student-written one-act plays. Swirnow Theater, Mattin Center. HW

W OR K S HO P S Thurs., Oct. 1, 1 p.m. “J-Share: Keep Your Files Online, Share If You Like,” a Bits & Bytes workshop intended for Homewood faculty, lecturers and TAs (staff are also welcome to attend). Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW

• University Parkway at West 39th St. 2 & 3 bedroom apartments located in a private park setting. Adjacent to Johns Hopkins University Homewood Campus and minutes from downtown Baltimore.

410-243-1216

105 West 39th St. • Baltimore, MD 21210 Managed by The Broadview at Roland Park BroadviewApartments.com

Need extra copies of ‘The Gazette’? A limited number of extra copies of The Gazette are available each week in the Office of Government, Community and Public Affairs, Suite 540, 901 South Bond St., in Fells Point. Those who know they will need a large number of newspapers are asked to order them at least a week in advance of publication by calling 443-287-9900.

September 28, 2009 â&#x20AC;˘ THE GAZETTE

Classifieds APARTMENTS/HOUSES FOR RENT

Bayview area, 2BR house w/finâ&#x20AC;&#x2122;d bsmt, W/D, prkng pad, no pets, sec dep + utils. Elaine, 410-633-4750. Bolton Hill, 1,500 sq ft, 10.5' ceilings, 1-2 lg BRs w/walk-in, marble BA w/whirlpool, living rm, kitchen, W/D, balcony, public transportation. $1,300/mo incl gas, water. sykewup@aol.com. Butchers Hill, 3-story house w/2BR suites, 2.5BAs, kitchen, W/D, dw, sec sys, huge backyd, walk to school. $1,395/mo. Sharon, 443-695-9073. Canton, 2BR, 2.5BA rehabbed TH, granite, stainless steel appls, exposâ&#x20AC;&#x2122;d brick, hdwd flrs and more, conv to JHH, 1 blk to water, best location, rent reduced. 410-340-6762. Canton (Lighthouse Point), 2BR, 2BA waterfront condo w/garage. $1,995/mo. sres1@comcast.net. Canton (2443 Fleet St), 2BR, 2.5BA house, new appls, CAC, granite countertops, jacuzzi, roofdeck, nr JHH/park/water/ Square. $1,700/mo + utils. 410-375-4862 or okomgmt@hotmail.com. Cedarcroft, 3BR, 1.5BA TH, dw, W/D. $1,250/mo + utils. 410-378-2393. Charles Village, corner 2BR, 2BA condo w/ balcony, very lg, clean, CAC, steps to JHMI shuttle, minimum 1-yr lease, all utils inclâ&#x20AC;&#x2122;d. 410-466-1698. Hampden, 3BR RH, CAC, W/D, finâ&#x20AC;&#x2122;d bsmt, fenced backyd, covered front porch, pets OK, quiet street, good neighbors, nr JHU/I-83/ transportation. $1,300/mo. 410-340-8402. Little Italy/Inner Harbor, immaculate 2BR, 2.5BA TH, 3-story, built 2005, stainless steel appls, granite, hdwd flrs, W/D, garage, 1 mi to JHMI. lloydths@gmail.com. Roland Park/Medfield (Highpointe at 4409 Falls Bridge Dr), 2BR, 1BA condo, great location close to JHU/Homewood in lower Roland Park area. $800/mo. edoh75@yahoo .com. Upper Fells Point, 2BR, 1BA apt, W/D, CAC, dw, kitchen, living rm, gated fence, backyd, mins to JHH. 410-733-4622. 419 Chadford Rd (off Homeland Ave),

M A R K E T P L A C E

3BR, 2.5BA luxury TH in gated community, w/garage, swimming pool, 20 mins to JHH, nr Gilman/Friends/Roland Park schools and Notre Dame/Loyola/Hopkins colleges. $2,000/mo. Ash, 443-386-6288. Cozy 1BR in priv home, priv entry, living rm, kitchen and BA, 1-yr lease, credit check reqâ&#x20AC;&#x2122;d, 1 person only; W/D, cable TV, Internet and utils inclâ&#x20AC;&#x2122;d. $875/mo. 410-828-9198.

HOUSES FOR SALE

Butchers Hill, 4BR, 4.5BA EOG unit, parkfront, 4,000 sq ft, newly renovâ&#x20AC;&#x2122;d, 2-car garage. $498,000. 443-421-6310. Canton, gorgeous 3BR, 2.5BA house, 3-story, gourmet kitchen, granite counters, stainless steel appls, balconies on each level, zoned HVAC, storage space, rooftop deck, 2-car prkng pad, walk to Square/waterfront. $599,900. June, 410-292-0100. Hampden, totally renovâ&#x20AC;&#x2122;d 3BR, 2.5BA house w/screened porch, fenced yd, priv prkng, walk to Homewood campus/shops/ restaurants/grocers/theater. $310,000. 919607-5860 or 410-962-5417. Harborview, 2BR, 1BA single-family house w/lg yd overlooking city. $168,500. 443-6042797 or lexisweetheart@yahoo.com. Timonium (8 Tyburn Ct), well-maintained, 4BR, 3BA house on cul-de-sac, open flr plan, eat-in kitchen, updated appls, bay windows, huge family rm, brick fp, deck overlooks wooded open space, 1-yr AHS warranty. $375,500. Debbie, 410-241-4724.

ROOMMATES WANTED

Lg, partly furnâ&#x20AC;&#x2122;d bsmt BR w/priv BA avail in renovâ&#x20AC;&#x2122;d Mayfield RH, across from Herring Run Park, nr Lake Montebello, 10 mins to JHMI, 5 mins to Morgan. $600/mo incl utils and wireless. mayfieldroom@gmail.com. Fully furnâ&#x20AC;&#x2122;d rm in newly renovâ&#x20AC;&#x2122;d TH, kitchen, living rm and toilet shared by 2 doctors, W/D free to use, Internet service avail, 1 min walk to JHMI. $360/mo + share of utils (pref long-term). gwzhang1@gmail.com.

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Roland Park - Large, bright, top floor, 1BD 1BA Condo for RENT. Convenient to Hopkins campus. Quiet bldg. with many amenities, CAC, pool, off-street parking, walk to shops/restaurants, etc. No pets. $925.00 + 1 yr. lease. 410-371-7298 or lisa.hausner@wachovia.com

Johns Hopkins / Hampden WYMAN COURT APTS. (BEECH AVE.) Effic from $570, 1 BD Apt. from $675, 2 BD from $775 HICKORY HEIGHTS APTS. (HICKORY AVE.) 2 BD units from $750 Shown by Appointment 410-764-7776 www.brooksmanagementcompany.com

lg kitchen, backyd, nr JHMI/95/Canton Square/grocery and other amenities. $600/ mo incl all. ky_helfrich@hotmail.com. Huge, beautifully furnâ&#x20AC;&#x2122;d rm in safe, quiet neighborhood close to Homewood campus, great for grad student. $470/mo + utils. rparkroom@yahoo.com. 1BR w/priv BA in 3BR split-level house (nr intersection Joppa and Harford Rd), laundry on premises. $550/mo incl Internet, cable and utils + sec dep ($500). Teresa, 443-850-3520 or teresatufano@gmail.com. F wanted to share lg, sunny, fully furnâ&#x20AC;&#x2122;d house w/respectful housemates and 3 cats, kitchen, living rm, dining rm, garden, porch, W/D. 410-963-8741. BR avail in great Canton house, nice neighborhood. $750/mo + 1/2 utils. 301-7850627 or rLontoc1@gmail.com. Nonsmoker wanted for furnâ&#x20AC;&#x2122;d, spacious rm in West Baltimore. $495/mo + utils + sec dep + references. 410-945-5951. Lg BR in 4BR Charles Village RH (3200 blk N Calvert), 2 blks to Homewood, W/D, living rm, dining rm, front porch, garden, backyd, picnic table, grill, pet-friendly (for additional $550 deposit), avail Oct 15. $550/mo incl utils. Tania, 443-850-8655.

CARS FOR SALE

â&#x20AC;&#x2122;02 Honda Odyssey minivan, slate green, power everything, orig owner, excel cond, 149K mi. $5,800. 410-365-1806.

ITEMS FOR SALE

Conn alto saxophone, mint condition. $650/best offer. 410-488-1886. Sofa, green leather, very soft and comfortable, good cond. $250. 410-542-0409 or ncarrey@comcast.net. Zenetti 20" rims (4) w/Pirelli P-zero type tires. $575/best offer. 443-827-0695 or romeyrome_04@yahoo.com. Queen-size sleep-sofa and loveseat, both in good cond, mattress still sealed in orig plastic cover. $300. sofas4sale@earthlink.net. Nikon 12-24mm lens, mint, $800; Haier air conditioner w/remote, 12,000 BTUs, almost new, $100; queen airbed w/pump, $35. 410807-5979 or aroop@cyberdude.com. Tripods, digital piano, beach chairs (2), 3-step ladder, stool, chair, computer, printer, microwave, reciprocating saw. 410-4555858 or iricse.its@verizon.net.

SPECIAL DISCOUNTS FOR JHH EMPLOYEES!

Red Cross pins from Europe, 20 different, $39; WWII commemorative pins from Russia, 30 different. $44. 443-517-9029 or rgpinman@aol.com.

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CROSS KEYS Charming one bedroom unit in GOODLOW HOUSE, 4th Fl. Reserved parking at door. Great for single person. Available October 1st. $1,025 inclusive. CALL 410-366-1293 or camcdjr@portnetworks.net.

Charles Village/Homewood

2BD/2BA orig. HWD flrs., new modern kitchen w/SS app., FP, renov. baths, DR, LR, sunroom, 1 park space. Right across from JHU and seconds from the shuttle. $309,750. See more online:

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Or contact Elena (201) 213-5354

Rent In Historic 1891 Elevator Secured Bldg. Central to all Baltimore Johns Hopkins Locations! Brand New Units: Only 4 left! $1250-$1400 2 BD 2 Full BA All with full size W/D, D/W, micro., carpet, CAC, Free off-street parking. 2300 N. Calvert St. 410 .764.7776 www.BrooksManagementCompany.com

SERVICES/ITEMS OFFERED OR WANTED

Multicultural fall festival, Oct 3 and 4, ethnic foods, free live entertainment, at St Matthew Orthodox Church in Columbia, Md. www.stmatthewfestival.org Wanted: Fluent French speaker to transcribe qualitative interviews from Senegal, flexible schedule, pay negotiable. tpoteat123@ gmail.com. Looking for new home for our lovable, 5-yrold mixed-breed dog, Bella. sarah.faimanifo @gmail.com. F needs housing for spring semester, will be moving in January. flemike@auburn.edu. Sublet wanted, mid-October to mid-November, walking distance to Homewood campus. 410-889-7730 or opicapauamarelo @gmail.com. Learn Arabic (MSA and colloquial) w/ native speaker and experienced teacher, all levels, lessons tailored to needs. thaerra@ hotmail.com. Horse boarding, 20 mins from JHU, beautiful trails from farm. $500/mo (stall board) or $250/mo (field board). 410-812-6716 or argye.hillis@gmail.com. Spending Thanksgiving in London? Seeking sightseeing and/or dining partner. Lagom335@hotmail.com.

Temporary furnâ&#x20AC;&#x2122;d rm avail in Patterson Park TH, perfect for visiting doctor/fellow/med student, W/D, Internet, cable, phone inclâ&#x20AC;&#x2122;d,

QUEST DENTAL KATHERINE GRANT COLLIER, DDS

6WD\ DW &DQWRQ ŕ˛Ź V RQO\ ERXWLTXH KRWHO 0LQXWHV IURP

Power washing, no job too small, free estimates. Donnie, 443-683-7049. Grass cutting and home/deck power washing, free estimates, very affordable. 410-3351284 or randy6506vfw@yahoo.com. We will come to your vehicle and detail it on the spot; all types of vehicles; call for quote. 443-421-3659. NYC bus trip, Sat, Dec 5, depart Towson 7:30am, Fallston 7:45am and Delaware House, 8:10am, arrive NYC about 10:30 am, depart 7pm. $50 (if paid by Sept 30, $55 after). 410-206-2830 or nlheyls@yahoo.com. Computer service provided via e-mail or on-site, tutoring, virus removal, system tuning, backup, troubleshooting. jhupcserv@ gmail.com. Guitar lessons w/experienced teacher, beginner through advanced, many styles taught; teacher will travel. Joe, 410-215-0693. Tutor avail: All subjects/levels; remedial, gifted and talented; also college counseling, speech and essay writing, editing, proofreading. 410-337-9877 or i1__@hotmail.com. Friday Night Swing Dance Club, open to public, no partners necessary. 410-583-7337 or www.fridaynightswing.com. Need help w/SAT, ACT or GRE? Go to www.baltimoreexambusters.com or e-mail baltimoreexambusters@yahoo.com. Arabic conversation partner wanted by intermediate Arabic student, could trade proofreading/editing English papers for conversation. somethingroyal@gmail.com. Piano lessons w/experienced teacher, Peabody doctorate, all levels/ages welcome. 410662-7951.

PLACING ADS Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines: â&#x20AC;˘ One ad per person per week. A new request must be submitted for each issue. â&#x20AC;˘ Ads are limited to 20 words, including phone, fax and e-mail.

â&#x20AC;˘ We cannot use Johns Hopkins business phone numbers or e-mail addresses. â&#x20AC;˘ Submissions will be condensed at the editorâ&#x20AC;&#x2122;s discretion. â&#x20AC;˘ Deadline is at noon Monday, one week prior to the edition in which the ad is to be run. â&#x20AC;˘ Real estate listings may be offered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.) Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attachments) to gazads@jhu.edu; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Baltimore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.

12 THE GAZETTE • September 28, 2009 S E P T .

2 8

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O C T .

Calendar COLLOQUIA

“Living a Lifetime Sentence as a Wife to a Palestinian Political Prisoner,” an Anthropology colloquium with visiting scholar Lotte Buch. 400 Macaulay. HW

Tues., Sept. 29, 4 p.m.

Tues.,

Sept.

29,

4:15

p.m.

“Catalysis, Chirality and Rotation Studied at the Single-Molecule Limit,” a Chemistry colloquium with Charles Sykes, Tufts University. 233 Remsen. HW “The Consolidation of Health Care Privatization in Colombia: Consequences and Restrictions,” a Program in Latin American Studies colloquium with Cesar Abadia-Barrero, Universidad Nacional de Colombia. 113 Greenhouse. HW

Wed., Sept. 30, 4 p.m.

Thurs., Oct. 1, 3 p.m. “Bionic Hearing: The Science and the Experience,” a Physics and Astronomy colloquium with Ian Shipsey, Purdue University. Schafler Auditorium, Bloomberg Center. HW

“Imagining a Molecular World: Chemistry, Distant Interference and the Scientific Imagination,” a History of Science, Medicine and Technology colloquium with Alan Rocke, Case Western Reserve University. Room 102, 3505 N. Charles St.

Thurs., Oct. 1, 3 p.m.

HW Thurs.,

Oct.

3:45

p.m.

“Using Pattern-based fMRI to Relate the Structure of People’s Neural Representations to Their Behavioral Performance,” a Cognitive Science colloquium with Rajeev Raizada, Dartmouth College. 134A Krieger. HW “God, Mind and Body: The Order of Knowledge in Descartes,” a Philosophy colloquium with Alan Nelson, University of North Carolina, Chapel Hill. Co-sponsored by Evolution, Cognition and Culture. 102A Dell House. HW

Thurs., Oct. 1, 4 p.m.

D I S C U S S I O N / TA L K S Mon., Sept. 28, 12:30 p.m.

“Foreign Investment in India,” an International Law and Organizations Program discussion with Marcia Wiss, Hogan & Hartson and SAIS. For more information and to RSVP, phone 202-6635982 or e-mail tbascia1@jhu.edu. 533 Rome Building. SAIS Tues., Sept. 29, 5 p.m. “The Status of Migrants in Today’s Europe,” a European Studies Progam discussion with Kathleen Newland, Migration Policy Institute. For more information and to RSVP, phone 202-663-5796 or e-mail ntobin@jhu.edu. Rome Building Auditorium. SAIS Wed., Sept. 30, 12:30 p.m.

“Resetting U.S.–Russian Relations: Dim Prospects for Success?” a Russian and Eurasian Studies Program discussion with David Kramer, German Marshall Fund.

From Singapore to Baltimore

MUSIC Tues., Sept. 29, 8 p.m. Artists from Yong Siew Toh Conservatory play music by Janacek, Franck, Poulenc and de Falla. (See photo, this page.) $15 general admission, $10 for senior citizens and $5 for students with ID. Friedberg Hall. Peabody

The Peabody Concert Orchestra performs music by Barber, Mozart and Dvorak, with guests Keng-Tuen Tseng, violin; and Victoria Chiang, viola. $15 general admission, $10 for senior citizens and $5 for students with ID. Friedberg Hall. Peabody

Fri., Oct. 2, 8 p.m.

Qian Zhou and Bernard Lanskey of Peabody’s sister conservatory, the Yong Siew Toh Conservatory of Music at the National University of Singapore, will perform at a special concert this week in Baltimore. Lanskey is director of Yong Siew Toh and Zhou, head of Strings. See Music.

Sat., Oct. 3, 7:30 p.m. The Peabody Camerata performs music by Hoffmann, Maw and Schoenberg. Griswold Hall. Peabody Sat., Oct. 3, 8 p.m. A cappella concert by the Mental Notes and guests. 101 Mattin Center (SDS Room). HW

S E M I N AR S

For more information and to RSVP, phone 202-663-5795 or e-mail egerasimov@jhu.edu. 812 Rome Building. SAIS Wed.,

Sept.

30,

4:15

p.m.

“Making Business Work Better for the Poor,” an International Development Program discussion with Harold Rosen, Grassroots Business Fund. For more information and to RSVP, phone 202663-5943 or e-mail nsander4@jhu .edu. 736 Bernstein-Offit Building. SAIS Wed.,

Sept.

30,

5:30

p.m.

“Pacific Alliance: Reviving U.S.– Japan Relations,” an American Foreign Policy Program panel discussion of Kent Calder’s book of the same name, with Calder, SAIS; Michael Mandelbaum, SAIS; Kenji Shinoda, deputy chief of mission, Embassy of Japan; and Terrence Hopman, SAIS. For more information and to RSVP, phone 202-663-5790 or e-mail kkornell@jhu.edu. Rome Building Auditorium. SAIS “Breaking the Silence,” a panel discussion with authors Azar Nafisi, Soheir Khashoggi, Zainab Salbi and Margaret Warner (moderator), senior correspondent on The NewsHour With Jim Lehrer. Part of SAIS’ Cultural Conversations series. For more information and to RSVP, phone 202-663-5635 or e-mail laustin@jhu.edu. Kenney Auditorium, Nitze Building. SAIS Wed., Sept. 30, 6 p.m.

“U.S.– German Relations in a New Era,” a SAIS Center for Transatlantic Relations discussion with various experts. Co-sponsored by American Bundestag Intern Network and Deutscher Akademischer Austausch Dienst. Reception will follow. For more information and to RSVP, phone 202-663-7730 or e-mail gdemian1@jhu.edu. Kenney Auditorium, Nitze Building.

Fri., Oct. 2, 10 a.m.

SAIS Fri., Oct. 2, 12:30 p.m. “Political and Technological Actions to Improve Food Security,” a SAIS International Development Program discussion with Joachim von Braun, director general, International Food Policy Research Institute. For information and to RSVP,

phone 202-663-5943 or e-mail developmentroundtable@jhu.edu. 200 Rome Building. SAIS “Opportunities and Challenges in the Inter-American System,” a SAIS International Law and Organizations Program discussion with Dinah Shelton, George Washington University Law School. For information and to RSVP, phone 202-663-5982 or e-mail tbascia1@ jhu.edu. 812 Rome Building. SAIS

Fri., Oct. 2, 12:30 p.m.

“Access to Experts,” a Center for Global Health career panel discussion with Jason Farley, SoN; Brenda Rakama, Jhpiego; and Heather Sanders, JHCCP. Other panelists TBA. Co-sponsored by the Office of Career Services. W1030 SPH (Anna Baetjer Room). EB

Mon., Oct. 5, 5:30 p.m.

G RA N D ROU N D S

“A Common IT Infrastructure Serving Both Research and Health Care,” Health Sciences Informatics grand rounds with Amnon Shabo, IBM Research Laboratory, Haifa, Israel. Sponsored by Health Policy and Management. W1214 SPH (Sheldon Hall). EB

Fri., Oct. 2, 12:15 p.m.

L E C TURE S

“La critique litteraire a ‘distance de loge’: La methode Starobinski,” a German and Romance Languages and Literatures lecture in French by Daniele Cohn, ENS in Paris. Co-sponsored by the Centre Louis Marin. 101A Dell House. HW

Mon., Sept. 28, 5:15 p.m.

Wed.,

Sept.

30,

5:15

p.m.

“Realismus und Verklarung: der Fall Fontane,” a German and Romance Languages and Literatures lecture in German by Daniele Cohn, ENS in Paris. Co-sponsored by the Centre Louis Marin. 101A Dell House. HW “Is Beauty Obsolete?” a German and Romance Languages and Literatures lecture in English by Daniele Cohn, ENS in Paris. Co-sponsored by the Centre Louis Marin. 101A Dell House. HW Thurs., Oct. 1, 5:15 p.m.

Mon., Sept. 28, 12:15 p.m.

“Flagella Assembly Studies in Chlamydomonas Lead to Insights Into Polycystic Kidney Disease and Other Cilia-Dependent Diseases,” a Carnegie Institution Embryology seminar with Joel Rosenbaum, Yale University. Rose Auditorium, 3520 San Martin Drive. HW Mon., Sept. 28, 4 p.m. “Targeting Aberrant Gene Silencing With Polyamine Analogues as a Strategy for Cancer Therapy,” a Biochemistry and Molecular Biology seminar with Robert Casero, SoM. W2030 SPH. EB

The David Bodian Seminar—“The Contribution of Short-Term Depression and Subthreshold Membrane Conductances to Directional Selectivity in Midbrain Neurons” with Maurice Chacron, McGill University. Sponsored by the Krieger Mind/ Brain Institute. 338 Krieger. HW

Mon., Sept. 28, 4 p.m.

“Covering Homology and Witt Constructions,” a Topology seminar with Bjorn Ian Dundas, University of Bergen, Norway. 308 Krieger.

Mon., Sept. 28, 4:30 p.m.

HW Tues., Sept. 29, noon. “Tobacco Product Regulation and Harm Reduction: Undoing the Damage From an Unregulated Marketplace,” a FAMRI Center of Excellence at Johns Hopkins seminar with Mitch Zeller, Pinney Associates. W2030 SPH. EB

“Group Choreography: Mechanisms Orchestrating Collective Movement of the Border Cells,” a Biological Chemistry seminar with Denise Montell, SoM. 612 Physiology. EB

Tues., Sept. 29, noon.

“Translating in vitro Toxicity Data to in vivo Risk: Application to Early Drug Discovery,” an Environmental Health Sciences seminar with James McKimm, CeeTox Inc. Cosponsored by the Center for Alternatives to Animal Testing. W7023 SPH. EB Tues., Sept. 29, 3 p.m.

Tues., Sept. 29, 3 p.m. “Nanomaterials as Environmental Pollutants: Can We Predict Fate, Transport and Biological Response?” a Geography and Environmental

Engineering seminar with Joseph Hughes, Georgia Tech. 234 Ames. HW Tues.,

Sept.

29,

4:30

p.m.

“Semi-Supervised Learning for Speech and Language Processing,” a Center for Language and Speech Processing seminar with Katrin Kirchhoff, University of Washington. B17 CSEB. HW Wed., Sept. 30, noon. “The Use of Propensity Scores in Mental Health Research,” a Mental Health seminar with Elizabeth Stuart, SPH. B14B Hampton House. EB Wed., Sept. 30, noon. “Membrane Traffic and Membrane Fusion in Endosomes and Lysosomes,” a Physiology seminar with Alexey Merz, University of Washington. 203 Physiology Research Conference Room. EB Wed., Sept. 30, 1 p.m. “Profits and Public Health: A Study of Corporations, the Laws That Govern Them and Strategies Designed to Influence Corporations’ Effects on the Public’s Health,” a Health Policy and Management thesis defense seminar with Helaine Rutkow. W1030 SPH (Anna Baetjer Room). EB Wed., Sept. 30, 3 p.m. “The Bergman-Szego Kernel on Complex Manifolds II,” a Complex Geometry seminar with Bernard Shiffman, KSAS. Sponsored by Mathematics. 308 Krieger. HW

“Shaping Nano-scale Crystals: From Shells to Technological Materials,” a Materials Science and Engineering seminar with Christine Orme, Lawrence Livermore National Laboratory. 110 Maryland. HW

Wed., Sept. 30, 3 p.m.

“Determinants of Condom Use With Female Sex Workers Among Male Clients in Sichuan Province, China,” a Health, Behavior and Society thesis defense seminar with Cui Yang. W2029 SPH. EB

Thurs., Oct. 1, 10 a.m.

Thurs., Oct. 1, noon. “Interactions of Viruses With Polarized Hepatocytes,” a Molecular Microbiology and Immunology/ Infectious Diseases seminar with David Anderson, Burnet Institute/Alfred Medical Research and Education Precinct, Melbourne, Australia. W1020 SPH. EB

Randolph Bromery Seminar— “Stratospheric Ozone and Its Coupling With Climate Change” with Richard Stolarski, NASA Goddard Spaceflight Center. 304 Olin. HW

Thurs., Oct. 1, noon.

“Vesicular

Continued on page 10

Calendar

Key

(Events are free and open to the public except where indicated.)

APL Applied Physics Laboratory BRB Broadway Research Building CSEB Computational Science and

EB HW PCTB SoM SoN SPH WBSB

Engineering Building East Baltimore Homewood Preclinical Teaching Building

School of Medicine School of Nursing School of Public Health Wood Basic Science Building