August 31, 2009 -- The Gazette by The Johns Hopkins University

If you’re sick, stay home. o ur 3 9 th ye ar

LE G O LE S S O N

Covering Homewood, East Baltimore, Peabody,

Plastic toy helps researchers

SAIS, APL and other campuses throughout the

learn what happens inside labon-a-chip devices, page 5

Baltimore-Washington area and abroad, since 1971.

H1N1 AND YOU Keep the flu virus to for a possible Plans yourself.

onslaught

of fall flu cases are set into

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August 31, 2009

The newspaper of The Johns Hopkins University

Volume 39 No. 1

A D M I N I S T R A T I O N

M O V E - I N

New provost steps into his post

Welcome to Johns Hopkins

By Dennis O’Shea

Homewood

Continued on page 3

HIPS / WILL KIRK

loyd Minor’s goal as provost is simple but daunting: to help every Johns Hopkins school become the best at what it does. “There is not one set path to achieving our individual and common goals,” Minor said last Minor’s goals week, shortly after his appointment was announced. are to share “At Johns Hopknowledge, kins, we have uniformity of values. facilitate If each of us sets the goal of excelcollaboration lence beyond our current status, and pursues that excellence with integrity, then Johns Hopkins University will not only be the pre-eminent research university in America but will achieve outstanding new advances in each of our divisions.” The path to those advances, he said, includes learning what works in each division and then widely sharing knowledge about best practices for faculty recruitment and retention, student recruitment, building programs, developing education and training opportunities for undergraduates and graduate students, and increasing diversity. “I have been inspired by recent efforts in the Provost’s Office to facilitate greater collaboration at the seams between schools and disciplines,” Minor said. “Those efforts are investments in our shared future as a university, and I look forward to continuing that very important work.” Minor, who will move into the provost’s office tomorrow, Sept. 1, has been a Johns Hopkins faculty member for 16 years and most recently director of the Department of Otolaryngology–Head and Neck Surgery in the School of Medicine. He said he is humbled and honored to serve as the university’s 13th provost and as senior vice president for academic affairs, and that he looks

President Daniels checks out the latest dorm gear as arriving students unload belongings outside the Hopkins Inn.

he nearly 80 percent humidity did little to wilt the smiles of the band of volunteers on hand to greet and assist the Class of 2013 on Friday, the first of two Move-In days. The welcome wagon performed like a finely tuned Johns Hopkins machine as SUVs, minivans and cars began to file through the Homewood campus’s north gate as early as 9 a.m.

The Class of 2013— and carloads of stuff— arrives at Homewood By Greg Rienzi

The Gazette

Greeters met the cars at the entrance; walkers escorted students to locations where they would pick up residence keys, J-cards and everything else that would make them official Johns Hopkins students; and movers helped parents unload their vehicles and then transported the students’ belongings to their rooms. Continued on page 6

A P P O I N T M E N T

Finance and Administration names new controller Gregory S. Oler, longtime Johns Hopkins employee, is tapped for position By Tracey A. Reeves

Homewood

longtime Johns Hopkins employee with natural leadership abilities and demonstrated technical acu-

In Brief

Homewood-JHMI shuttles; President’s Day of Service; Diversity Conference; new rankings

men has been tapped to be the university’s new controller. Gregory S. Oler, a certified public accountant who previously served as the university’s director of General Accounting, began his new job last month. He succeeds Phil Tahey, who recently left the university after nearly four years as controller. Michael Strine, university vice president for finance and treasurer, said that Oler brings just the right mix of skill and leadership to the position. “He was far and away the leading choice

over strong candidates, including those from leading higher education, nonprofit and private sector entities,” Strine said. “Greg’s strengths in leadership and technical knowledge were demonstrated to the broad and representative group across the university and health system. “He simply rose to the top of the list,” Strine added. “He knows the financial rules and regulations. He’s a trained accountant. He has knowledge of Hopkins, and the fact

C A L E N D AR

Student job fair; TA orientation; Homewood grad student welcome; WebCT workshop

Continued on page 9

10 Job Opportunities 10 Notices 11 Classifieds

2 THE GAZETTE • August 31, 2009 I N B R I E F

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Homewood-JHMI shuttle schedule updated, effective today

he Homewood-JHMI Shuttle schedule has been updated, effective today, Aug. 31. The new schedule contains slight modifications, notes upcoming holidays and is available on the buses and online at www.parking.jhu.edu. Any questions, concerns or feedback can be sent to shuttles@jhu.edu.

Registration open now for President’s Day of Service

t the request of President Ronald J. Daniels, the Center for Social Concern is coordinating a Homewood campus day of service on Saturday, Sept. 12, as part of the president’s inauguration weekend. Faculty, staff and students are invited to spend the afternoon volunteering to benefit the greater Baltimore community. Projects included in “Be the Change: The President’s Day of Service” are stream cleanups, sorting donated clothing, painting a high school library and cafeteria, cleaning vacant lots, helping in community gardens and harvesting produce for the hungry. Pre-registration is required online at www .jhu.edu/csc/events/presidentsdayofservice .shtml. The last day to sign up is Monday, Sept. 7.

Diversity Leadership Council announces conference plans

T This event is for JHU students, residents of the Questions? Contact Salem Reiner neighborhoods surrounding JHU’s Homewood campus at commrelations@jhu.edu or 443-287-9900 and other members of the university community.

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he sixth annual Diversity Leadership Council’s Diversity Conference will be held on Thursday, Nov. 5. The theme is “Leadership: Transforming Diversity Into Inclusion,” and the opening speaker will be Deborah Elam, chief diversity officer for General Electric Global. Johns Hopkins President Ronald J. Daniels will give the luncheon speech. Proposals for presentation topics are now being solicited and must be submitted by Thursday, Sept. 10, for full consideration. Possible topics are Recruiting and Retaining Diverse Faculty and Staff, Race and Gender Relations, the Multigenerational Workplace, Lesbian Gay Bisexual Transgender Issues, First Amendment Rights/Civility and Community Engagement. The event will be held from 8 a.m. to 2 p.m. on the Homewood campus; registration will open in mid-September. For more information about submitting proposals, and for other questions, e-mail diversity_ conference@jhu.edu or call Patrese Frazier at 410-516-8075; TTY 410-516-6225.

‘U.S. News & World Report’ releases Best Colleges rankings

ohns Hopkins takes a step up this year, moving from the 15th to 14th spot in U.S. News & World Report’s latest tally of the country’s Best National Universities,

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E d i to r Lois Perschetz Writer Greg Rienzi P r od u c t i o n Lynna Bright C op y E d i to r Ann Stiller P h otog r a p h y Homewood Imaging and Photographic Services A d v e rt i s i n g The Gazelle Group Business Dianne MacLeod C i r c u l at i o n Lynette Floyd Webmaster Tim Windsor

part of its annual Best Colleges issue. Harvard and Princeton tied this year for the top ranking, followed by Yale at No. 3. In rankings for best undergraduate engineering programs among schools whose highest degree is a PhD, Johns Hopkins is tied for 14th, the same as in the past four years. In specialty rankings, JHU retains its No. 1 spot in biomedical engineering, followed again by Duke, Georgia Tech, UC–San Diego and MIT. In environmental engineering/environmental health, Johns Hopkins is tied at No. 5 with Georgia Tech, following Stanford, California, Illinois and Michigan. In an unranked section called “Programs to Look For,” Johns Hopkins is included in the category of “Undergraduate Research/ Creative Projects.” In the “Great Schools, Great Prices” section, JHU is listed 18th among national universities, up from 19th last year. This category rates “best value” as indicated by a formula comparing a school’s U.S. News ranking to its net cost of attendance. For complete listings, go to www.usnews .com/sections/rankings/index.html.

Injury Center receives five-year renewal from CDC

he Center for Injury Research and Policy at the Johns Hopkins Bloomberg School of Public Health is one of four injury control research centers nationwide selected for funding by the Centers for Disease Control and Prevention’s National Center for Injury Prevention and Control. It was awarded $4.87 million over five years. Injury control research centers study the three core phases of injury control—prevention, acute care and rehabilitation—and serve as training and information centers for the public and health professionals. The Johns Hopkins Center for Injury Research and Policy was one of the first centers for excellence in injury research funded by the CDC and has been in existence since 1987. Its work spans the spectrum of unintentional and intentional injury across the lifespan and across the globe, with a strong focus on translation research as well as education and outreach to promote effective programs and policies.

National Society of Collegiate Scholars chapter receives gold

he Johns Hopkins chapter of the National Society of Collegiate Scholars, an honors group for highachieving freshmen and sophomores, was awarded gold status at the organization’s Honor Gala, held recently in Washington, D.C. An NSCS spokesperson said the JHU members “have gone above and beyond by creating innovative programs and an exceptional experience for their members.”

Contributing Writers Applied Physics Laboratory Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Audrey Huang, John Lazarou, David March, Katerina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort

The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date. Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 410343-3362 or gazellegrp@comcast.net.

August 31, 2009 • THE GAZETTE

Provost forward to forming a close working partnership with President Ron Daniels and collaborating with faculty and staff members all across the university. “Anyone coming into this job is going to have a lot to learn” about all the university’s divisions, institutes and other entities, said Minor, who has held the endowed Andelot Professorship in Laryngology and Otology and joint appointments in the departments of Biomedical Engineering and Neuroscience. “I’m excited about that,” he said. “It’s going to be a wonderful process. The opportunity to work with people with such diverse backgrounds and interests is one of the wonderful things about the job of provost.” The provost is Johns Hopkins’ chief academic officer and the second-ranking member of the senior administration, coordinating and promoting the university’s research and education initiatives and overseeing a multitude of areas including—among many others—regulatory compliance, accreditation and institutional equity. “Lloyd Minor is an exceptional scholar, clinician and scientist with an outstanding record in academic leadership,” said Daniels, who recommended the appointment to the executive committee of the university’s board of trustees. “He brings to university leadership a driving passion to make Johns Hopkins stronger in all its crucial dimensions: research, education and service. His passion is surpassed only by his ability to build consensus and implement ambitious, strategic priorities that are characterized by an uncompromising commitment to academic excellence.” Minor was recruited to Johns Hopkins University in 1993 as an assistant professor and became department director in 2003. He said he has learned a lot in his time at the university. “Leadership is first and foremost about working with people, promoting and encouraging the development and success of the

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Continued from page 1

Lloyd Minor in front of a portrait of Johns Hopkins in the Billings Administration Building, the original entrance to The Johns Hopkins Hospital, in East Baltimore.

people around you,” he said. “That’s what I’ve tried to do, first as a faculty member, then as a department director, and that is what motivated me to look at a leadership position and what excites me about this position. It comes down to working with people and shared values and developing shared strategies to promote excellence.” During his six-year tenure as department director, the School of Medicine’s equivalent of department chair, Minor has worked to recruit and retain an outstanding and diverse faculty, expanded annual research funding by more than 50 percent, increased clinical activity by more than 30 percent and strengthened teaching and student training.

He has served in other important roles in the School of Medicine, including chair of the Administrative Committee of the Medical Board and of the Practice Management Committee, and member of the Standing Committee on Discipline, the board of governors of the Clinical Practice Association and the Professorial Promotions Committee. Minor is known internationally for his work on the physiological processes that mediate sensing and controlling motion and is most widely recognized for research on how the body perceives head motion and maintains balance. Other areas of expertise include Meniere’s disease and signal-processing mechanisms in vestibular pathways.

Minor has long been applauded as deeply committed to teaching as well as to research, Daniels said. He has reached out repeatedly over the years to teach undergraduates from the university’s Homewood campus and is a revered teacher in the School of Medicine, the president said. Minor is a fellow of the American College of Surgeons and American Academy of Otolaryngology–Head and Neck Surgery, past president of the Association for Research in Otolaryngology and past chair of the Auditory Research Study Section of the National Institutes of Health. Minor succeeds Kristina Johnson, who had been provost since 2007 before she left this year to serve in the Obama administration as undersecretary of the Department of Energy. Scott L. Zeger, vice provost for research and a professor in the Bloomberg School of Public Health, has served as interim provost. “Dr. Zeger has been overseeing two portfolios since March, and I am enormously grateful to him for his support and dedication over the past few months,” Daniels said. “I am particularly appreciative for the role that he has played in coordinating the university’s emergency preparedness efforts while advancing its academic agenda in a number of areas. Dr. Minor and I look forward to continuing to work closely with Dr. Zeger on the ambitious agenda he has unleashed for university research, which includes a number of exciting interdisciplinary initiatives.” Minor earned his bachelor’s and medical degrees from Brown University in 1979 and 1982. He completed his surgical residency at Duke University, followed by a four-year postdoctoral research fellowship in vestibular physiology and then a residency in otolaryngology–head and neck surgery at the University of Chicago. Before coming to Johns Hopkins, he was a clinical fellow at the Otology Group and the EAR Foundation in Nashville, Tenn. Minor, 52, was born in Little Rock, Ark. He is married to Lisa Keamy, a family practice physician in Baltimore, and together they have two children, Emily, 18, and Samuel, 15. G

Is there long-term brain damage after heart bypass surgery? B y D av i d M a r c h

Johns Hopkins Medicine

rain scientists and cardiac surgeons at Johns Hopkins have evidence from 227 heart bypass surgery patients that the long-term memory losses and cognitive problems they experience are due to the underlying coronary artery disease itself and not to ill aftereffects from having used a heart-lung machine. Researchers say that their latest findings explain study results presented last year that showed the heart-lung machines—used to pump blood and supply the body with oxygen while the heart is stopped during surgery—did not cause postoperative longterm brain deficits. “Our results hammer home the message that heart-lung machines are not to be blamed for cognitive declines observed years later in people who have had bypass surgery,” said lead study investigator Ola A. Selnes, a professor of cognitive neuroscience in the Neurology Department at the School of Medicine. The new results stand in contrast to the impact of heart-lung machines on so-called “pumphead” syndrome of temporary memory loss, impaired vision and slurred speech observed right after surgery in many heart bypass patients. According to another of the study’s investigators, William A. Baumgartner, former cardiac surgeon in charge at The Johns Hopkins Hospital, the short-term syndrome led many surgeons and patients alike to assume that long-term losses must also be due to the use of heart-lung machines, an assumption proved wrong by the latest evidence. “Now we can assure these people that the disease, not the machine itself, is the cause

of the problem,” said Baumgartner, vice dean for clinical affairs and the Vincent L. Gott Professor in Cardiac Surgery at the School of Medicine and its Heart and Vascular Institute. Neurologists on the study team say the results highlight the need for further research into the long-term consequences of cardiovascular disease on the brain, and the brain’s complex network of tiny blood vessels. “Neuroscientists do not yet have good measures on heart disease and how the burden of this disease impacts brain function,” said study senior investigator and neurologist Guy McKhann, a professor at Johns Hopkins. McKhann plans brain imaging studies to look at changes before and after heart bypass surgery to determine if there are any early, even predictive, signs of cognitive problems, and if surgery could fix them. He notes that previous studies have found some 50 percent of patients awaiting heart bypass surgery already have some early indication of brain damage. “If we can eventually figure out how heart disease and decline in brain function are linked over the long term, then it is feasible to think that we can diagnose problems earlier and, ultimately, intervene and prevent, or even lessen, these cognitive problems,” McKhann said. During heart bypass surgery, more formally known as coronary artery bypass grafting, blood vessels from other parts of the body are removed and reattached to the heart to restore open blood flow when the natural blood supply becomes constrained from coronary arteries that are diseased and blocked. Patients often spend an hour or more connected to a heart-lung machine during the surgery.

Results of the new study, published in the August issue of Annals of Thoracic Surgery, showed no differences in brain impairment in those who had heart bypass surgery, including a group of 75 heart patients who had so-called off-pump bypass surgery, and another group of 99 heart patients who opted for drugs and arterial stents to keep their blood vessels open instead of bypass, with none requiring use of a heart-lung device. All 326 patients in the three groups were found to have experienced significant cognitive decline over the six-year study period on 16 different scores of verbal and visual memory when compared to 69 heart-healthy people who had no known risk factors for coronary artery disease. The study, on heart patients from the Baltimore-Washington, D.C., region, is believed to be the first controlled study of its kind directly looking at the underlying causes of brain impairment, a phenomenon seen since the 1960s, when the coronary artery bypass grafting procedure was first introduced. Adding to patients’ fears was a 2001 report by researchers elsewhere that found that 42 percent of heart bypass patients experienced some long-term cognitive impairment. McKhann says that CABG has “really evolved” along with heart disease treatment since the heart bypass machines and restorative procedure were first introduced, with procedure volumes peaking in the 1990s but dropping afterward as physicians and patients began opting for less-invasive procedures. According to the latest estimates from the American Heart Association, roughly 469,000 CABG procedures were performed in the United States in 2005 on some 261,000 patients. McKhann points out that the procedure

remains in widespread practice as patients considered safe for having the CABG procedure are getting older and sicker. People as old as 80, he says, are now candidates for CABG. “With these new data, patients can now more accurately and confidently weigh the risks and benefits of bypass surgery against off-pump surgery or even more conservative options,” McKhann said. All study participants underwent an hourlong series of cognitive tests five times during regularly scheduled annual study visits. In one test of verbal memory, patients had to memorize 15 words in a specific order within 30 minutes. In a test of visual memory, patients had to trace on paper a complex diagram and then redraw it after the diagram was taken away. Funding support for this study was provided by the National Institute of Neurological Disorders and Stroke and by the Dana Foundation. In addition to McKhann, Baumgartner and Selnes, researchers involved in this study, conducted from 1997 through 2008, were Maura Grega, Maryanne Bailey, Luu D. Pham and Scott Zeger, all of Johns Hopkins.

Related Web sites Johns Hopkins Heart and Vascular Institute:

www.hopkinsmedicine.org/heart_ vascular_institute

‘Annals of Thoracic Surgery’:

http://ats.ctsnetjournals.org/ current.shtml

4 THE GAZETTE • August 31, 2009

Preparing for the arrival of students—and the H1N1 virus After months of planning, university puts its anti-flu campaign into motion By Greg Rienzi

The Gazette

hen it comes to how to mitigate the H1N1 flu at Johns Hopkins, the writing is on the wall—or, actually, the posters and

hand sanitizer are. With the return of students and flu season, the university and the Johns Hopkins Office of Critical Event Preparedness and Response, or CEPAR, have issued renewed calls for precaution and vigilance to minimize the impact of H1N1 outbreaks on Johns Hopkins campuses. Medical experts predict that H1N1, previously referred to as swine flu, will intensify during the fall and winter since it has remained active during the summer. The virulence of H1N1, by most indications, remains relatively low. Most patients suffer mild symptoms, comparable to those of seasonal flu. Though some patients become seriously ill, most recover quickly and without complications. However, the threat remains that the virus could mutate and become more virulent. To help safeguard the Johns Hopkins community, staff and faculty from across the divisions have invested many hours this summer in planning for what seems an almost inevitable resurgence of H1N1 cases. One group has met weekly to help the Provost’s Office craft a comprehensive universitywide flu action/response plan. It includes contingency plans for both students and employees, and covers both the situation where the H1N1 remains relatively benign and the event where it mutates into something more virulent. The plan, currently under review by senior administration and the Council of Deans, will be released soon. To date, the general message to students, staff and faculty has been to act responsibly and protect themselves and others from infection. Colleges and universities across the nation have taken similar stances. At Johns Hopkins, the first visible manifestations of this H1N1 awareness campaign have been a series of posters—displayed in hallways, restrooms, cafeterias and other public places—that remind people to stay home if they’re sick and to practice good hygiene, such as covering their mouth and nose with a tissue when coughing or sneezing, and washing hands with soap and warm water for a minimum of 20 seconds. The posters, crafted by the university’s Office of Marketing and Creative Services, are available for download at flu.jhu.edu, the univeristy’s H1N1 information center.

School of Public Health testing H1N1 flu vaccine By Tim Parsons

School of Public Health

he Johns Hopkins Bloomberg School of Public Health has been selected by CSL Biotherapies of Australia as the lead site to conduct tests for a vaccine against the new H1N1 influenza. The trial will vaccinate 1,300 adults from sites across the United States and is one of the largest H1N1 vaccine trials currently under way. The trial is being conducted through the Bloomberg School’s Center for Immunization Research. Vaccinations began at the school on Aug. 25. “The H1N1 pandemic has already had a significant impact on health and society in general. Those most at risk are children, young adults and pregnant women, as well as people with underly-

Some divisions have produced their own H1N1 fliers using materials from the Centers for Disease Control and Prevention or other sources. Divisions are also making hand sanitizer readily available in many public places, such as outside elevator doors and in food halls. Earlier this summer, a broadcast message went out to students from Scott Zeger, interim provost and senior vice president for academic affairs, asking them to take necessary precautions to limit the risk of spreading infections. For example, if students become ill with flulike symptoms once on campus, they are asked to go to the student health center serving their school or campus and not to go to class, a laboratory, the library, a dining hall or other public place where they might expose others. A message was also recently sent to faculty, urging them to be especially accommodating this fall to students who are sick and not to penalize them for such absences by offering flexibility with assignments and exam schedules. Staff and faculty have also been told not to come to work if they are sick and to return to work only when they are symptom-free for 24 hours without the benefit of medication. Jonathan Links, deputy director of CEPAR, who was asked by Zeger to coordinate the university’s flu response, said that the university is currently viewing H1N1 the same way as seasonal flu, which it takes very seriously. “Right now H1N1 is acting like seasonal flu, so there is no need to have dramatically different policies and procedures,”

Announcing Fall Workshop Schedule

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ing medical conditions. A safe, effective vaccine to protect those at highest risk is a public health priority,” said Kawsar Talaat, principal investigator of the vaccine trial and assistant scientist in the Bloomberg School’s Department of International Health. Ruth Karron, a professor in the Bloomberg School’s Department of International Health and director of both the Center for Immunization Research and the Johns Hopkins Vaccine Initiative, is co-principal investigator of the vaccine study. The new H1N1 influenza strain was first described in April and is easily transmissible from person to person. Unlike seasonal flu, most people are unlikely to have immunity to the new virus strain. On June 11, the World Health Organization declared that the spread of the new H1N1 strain met the criteria for an influenza pandemic. The trial, a Phase II study, will measure

the safety of and immune response to CSL’s H1N1 flu vaccine at three separate dosing levels. Two groups of participants will be enrolled in the trial: adults 18 to 64 and adults older than 65. Each group will receive two injections of vaccine three weeks apart. Researchers will sample the participants’ blood at three and six weeks after the first vaccination to check for antibodies for H1N1, which indicate an immune response to the vaccine. Also, participants will keep a diary of any symptoms or reactions following vaccination. Said Karron, “This trial will help assess the safety of this new H1N1 vaccine and determine how well it evokes an immune response. By looking at the immune response to several different doses of H1N1 vaccine, this trial will help to determine the best dose to use in vaccination campaigns.”

said Links, a professor and deputy chair of Environmental Health Sciences at the Bloomberg School of Public Health. “The cornerstone of the current plan is caution. We will try to maintain business as usual as best as we possibly can.” Links said that CEPAR, which coordinates the institutionswide response to a critical event, has been planning for a pandemic for several years and will continue

programs, except those studying abroad or at other off-campus locations. H1N1 vaccination will also be offered to employees, as it is annually for seasonal flu. Since H1N1 and seasonal flu are different, students, faculty and staff should also get the regular seasonal flu vaccine. In addition to the universitywide response, many divisions are sending out their own messages of prevention. At the Homewood schools and Peabody, officials informed parents and students about the flu plan during orientation. Peabody also collected local emergency contact information from all residential students in the event that they have to find a safe haven if residence halls close. The Peabody Crisis Management and Planning Committee has met regularly and is in close contact with CEPAR, as well as the Homewood Student Crisis Committee. “We are all working collaboratively to make sure that everything is addressed, and that we can respond as effectively as we can,” said Katsura Kurita, Peabody’s associate dean for student affairs. In the case of an H1N1 outbreak at SAIS, every attempt will be made to keep the school running if the virus’s characteristics remain similar to those of seasonal flu. Should there be a school closure, SAIS has a “substantial” business continuity plan in place that addresses both the administrative and academic aspects of life there, according to George Petasis, chief information officer at SAIS. SAIS faculty and staff have been tagged with such designations as “mission critical” and “mission essential” and have been ensured that certain operations will continue despite closure. The school has also built up its telecommuting capabilities so that sick staff members can adhere to JHU guidelines and remain at home to work or recover. “We are also encouraging all SAIS faculty to make as much course material as possible available online to absent students, including course lectures, through the Sakai course management system and our library’s Electronic Reserves System,” Petasis said. Gabor Kelen, director of CEPAR and chairman of the Department of Emergency Medicine in the School of Medicine, has said that people need to be reminded that we are in the midst of a global pandemic. “Everyone needs to be engaged and should learn as much as they can about what they can do to avoid getting or spreading this virus and preparing for an intensification soon after the school season starts. Preparing or determining what to do after it hits will be too late,” Kelen said. For more information, go to flu.jhu.edu or www.flu.gov.

to actively monitor the flu’s spread and to interact with the CDC, the state Department of Health and Mental Hygiene, and the Baltimore City Health Department. The university, Links said, remained in response mode throughout the summer as cases of H1N1 continued to pop up nationwide, including at Johns Hopkins University programs held at campuses throughout the country. Links said that particular precaution was taken with the Center for Talented Youth’s many summer programs, including those held overseas. Models put together by experts from the School of Public Health presently indicate that even if H1N1 is widespread this fall, the number of sick students, faculty and staff at any one time is likely to be relatively small, even if the cumulative number grows. In the event that H1N1 virus mutates and becomes more dangerous, and even more lethal, however, the university may need to act more aggressively to prevent infection of students by suspending classes and closing residence and dining halls, Links said. An H1N1 vaccine is coming but likely won’t be available until mid-October at the earliest. The exact date will become clear only as testing is completed, manufacturing ramps up and national vaccination priorities are set. When it does become available, Johns Hopkins intends to provide the vaccine to students in traditional full-time

August 31, 2009 • THE GAZETTE

E N G I N E E R I N G

LEGOs show researchers what happens inside lab-on-a-chip By Mary Spiro

Institute for NanoBioTechnology

HIPS / WILL KIRK

ohns Hopkins engineers are using a popular children’s toy to help them visualize the behavior of particles, cells and molecules in environments too small to see with the naked eye. These researchers are arranging little LEGO pieces shaped like pegs to re-create microscopic activity taking place inside lab-on-a-chip devices at a scale they can more easily observe. These lab-on-a-chip devices, also known as microfluidic arrays, are commonly used to sort tiny samples by size, shape or composition, but the minuscule forces at work at such a small magnitude are difficult to measure. To solve this small problem, the Johns Hopkins engineers decided to think big. Led by Joelle Frechette and German Drazer, both assistant professors of chemical and biomolecular engineering in the Whiting School of Engineering, the team used beads just a few millimeters in diameter, an aquarium filled with goopy glycerol and the LEGO pieces arranged on a LEGO board to unlock mysteries occurring at the micro- or nanoscale level. Their observations could offer clues on how to improve the design and fabrication of lab-on-a-chip technology. Their study concerning this technique was published in the Aug. 14 issue of Physical Review Letters. The idea for this project comes from the concept of “dimensional analysis,” in which a process is studied at a different size and time scale while keeping the governing principles the same. “Microfluidic arrays are like miniature chemical plants,” Frechette said. “One of the key components of these devices is the ability to separate one type of constituent from another. We investigated a microfluidic separation method that we suspected would remain the same when you scale it up from micrometers or nanometers to something as large as the size of billiard balls.” With this goal in mind, Frechette and Drazer constructed an array using cylindrical LEGO pegs stacked two high and arranged in rows and columns on a LEGO board to create a lattice of obstacles. The board was attached to a Plexiglas sheet to improve its

German Drazer, assistant professor of chemical and biomolecular engineering, uses a LEGO board to study the way particles behave in a microfluidic device.

stiffness and pressed up against one wall of a Plexiglas tank filled with glycerol. Stainless steel balls of three different sizes, as well as plastic balls, were manually released from the top of the array; their paths to the bottom were tracked and timed with a camera. The entire setup, Drazer said, cost a few hundred dollars and could easily be replicated as a science fair experiment. Graduate students Manuel Balvin and Tara Iracki, and undergraduate Eunkyung Sohn, all from the Department of Chemical and Biomolecular Engineering, performed multiple trials using each type of bead. They progressively rotated the board, increasing the relative angle between gravity and the columns of the array (that is, altering the forcing angle). In doing so, they saw that the large particles did not move through the array in a diffuse or random manner as their small counterparts usually did in a microfluidic array. Instead, their paths were deterministic, meaning that they could be predicted with precision, Drazer said. The researchers also noticed that the path followed by the balls was periodic once the balls were in motion and coincided with the direction of the lattice. As the forcing angle increased, some of the balls tended to shift

over one, two, three or as many as four pegs before continuing their vertical fall. “Our experiment shows that if you know one single parameter—a measure of the asymmetry in the motion of a particle around a single obstacle—you can predict the path that particles will follow in a microfluidic array at any forcing angle, simply by doing geometry,” Drazer said. The fact that the balls moved in the same direction inside the array for different forcing angles is referred to as phase locking. If the array were to be scaled down to microor nanosize, the researchers said they would expect these phenomena still to be present and even increase depending on the factors such as the unavoidable irregularities of particle size or surface roughness.

HEV exposure was less common in children than in adults and generally increased with age. Males had higher prevalence of HEV antibodies than women. Individuals living in the South were less likely to be seropositive; those in the Midwest had the highest regional seropositive estimates. “The very high prevalence of antibodies to the HEV among residents of the U.S. was quite surprising; however HEVassociated acute hepatitis has been increasingly reported among residents of western European countries. In addition, HEV infections are an important cause of illness and even death among populations in developing counties, especially among women who are infected during pregnancy,” said Kenrad E. Nelson, senior author of the study and professor in the Bloomberg School’s Department of Epidemiology. The study was supported by a grant from the National Institute of Allergy and Infectious Diseases, a member of the National Institutes of Health. In addition to the Johns Hopkins authors, the study was published by Robert H. Purcell and Ronald E. Engle, both of NIAID; and Geraldine M. McQuillian and Annemarie Wasley, both of the Centers for Disease Control and Prevention. —Tim Parsons

Related Web sites German Drazer’s lab:

http://microfluidics.jhu.edu/Home

Joelle Frechette’s lab:

http://ww2.jhu.edu/frechette

Institute for NanoBioTechnology:

http://inbt.jhu.edu

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Hepatitis E more widespread in U.S. than previously suspected xposure to hepatitis E virus appears to be common in the United States, although disease following exposure is rarely reported, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. The study found antibodies indicating exposure to HEV in 21 percent of the U.S. population between 1988 and 1994. HEV is a major cause of viral hepatitis in many developing countries, but how it is spread in developed countries is not fully known. The study is published in the July 1 issue of the Journal of Infectious Diseases. “Our study shows that animals could play an important role in the spread of HEV in the U.S. Having a dog or pet in the home or consuming meats like liver and other organs were significantly associated with increased odds of exposure to HEV,” said lead author Mark H. Kuniholm, a 2007 graduate of the Bloomberg School of Public Health. For the study, the research team relied on data from the Third National Health and Nutrition Examination Survey, known as NHANES III, conducted by the National Center for Health Statistics between 1988 and 1994. Blood samples from more than 18,000 participants representing a cross section of the U.S. population were tested for antibodies for HEV. According to the results,

“There are forces present between a particle and an obstacle when they get really close to each other which are present whether the system is at the micro- or nanoscale or as large as the LEGO board,” Frechette said. “In this separation method, the periodic arrangement of the obstacles allows the small effect of these forces to accumulate, and amplify, which we suspect is the mechanism for particle separation.” This principle could be applied to the design of micro- or nanofluidic arrays, she added, so that they could be fabricated to “sort particles that had a different roughness, different charge or different size. They should follow a different path in an array and could be collected separately.” Phase locking is likely to become less important, Drazer cautioned, as the number of particles in solution becomes more concentrated. “Next,” he said, “we have to look at how concentrated your suspension can be before this principle is destroyed by particleparticle interactions.” Drazer and Frechette are both affiliated faculty members of the Johns Hopkins Institute for NanoBioTechnology. The research was funded by grants from the National Science Foundation and the American Chemical Society Petroleum Research Fund.

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6 THE GAZETTE • August 31, 2009

Setting priorities for patientsafety efforts means hard choices

s it more urgent for hospitals, doctors and nurses to focus resources on preventing the thousands of falls that injure hospitalized patients each year, or to home in on preventing rare but dramatic instances of wrong-side surgery? Is it best to concentrate immediately on preventing pediatric medical errors, or on preventing drug interactions in the elderly? With efforts to improve patient safety gathering momentum, two Johns Hopkins experts, one in patient safety and the other in bioethics, urge policy-makers to weigh in about which safety interventions deserve the most urgent attention when it’s clear that resources are limited. In a commentary in the Aug. 26 issue of the Journal of the American Medical Association, the two suggest that health policy– makers have yet to come to grips with the complexity of setting such priorities, and that time is of the essence. “The importance of patient safety to people’s lives and the quality of health care is clear, but there aren’t enough resources to devote to everything simultaneously,” says Ruth R. Faden, executive director of the Johns Hopkins Berman Institute of Bioethics. Faden co-authored the JAMA commentary with award-winning patient safety expert Peter J. Pronovost, a professor in the departments of Anesthesiology and Critical Care Medicine and of Surgery and director of the Johns Hopkins Quality and Safety Research Group. Noting that many patient safety interventions are patterned after safety efforts in commercial aviation, Pronovost—whose “cockpit”-style checklists for intensive care unit personnel are one example—points out that deciding patient safety priorities is infinitely more complicated than similar efforts to protect passenger safety. Aviation safety, Pronovost says, is focused almost solely on a single goal—preventing death—while patient safety involves a variety of technologies, treatment risks, judgments and possible outcomes in diverse populations.

“While we’re literally all in the same plane with aviation safety, the concerns are very different in health care,” he says. “You have different kinds of patients in different settings, facing different risks from errors and mistakes.” Among the social, ethical, scientific and political factors policy-makers should consider, the Johns Hopkins pair writes, is whether to give priority to medical errors that are rare, devastating and likely to involve individual culpability in a limited setting, such as wrong-side surgery, or to more frequent, systemic problems, such as falls, that are more widespread. When resources are strained, they say, policy-makers need to consider tough choices, such as whether to give more focus to safety issues involving those with a good prognosis rather than to those in which survival from the underlying illness is unlikely. Fundamentally, the authors say, informed public policy requires open debate about criteria for setting priorities in the first place. “Choosing patient safety priorities will mean tradeoffs, and policy-makers should opt for a transparent, accountable and ethical framework to set decisions,” Faden says. —Christen Brownlee

Move-In

their vehicles to be unloaded. Daniels later greeted students at the Hopkins Inn, a bedand-breakfast lodging located on St. Paul Street that the university has leased to meet housing needs. Move-In day begins a busy first week for the 1,350 freshmen. On Sunday, they took part in the New Student Convocation, where President Daniels and the Homewood deans addressed them. On Wednesday, the first day of classes, upperclassmen will formally welcome the freshmen at the inaugural First Night celebration, a candlelight induction ceremony followed by a campuswide party. The Class of 2013 also rang in a new Johns Hopkins tradition on Move-In days: the signing of the logbook. The same students will sign out in the logbook, and leave a note if they want, on their commencement day. G

Continued from page 1 Jonny DiTroia, Orientation 2009’s communications chair, zipped like a hummingbird from vehicle to vehicle, warmly welcoming parents and ensuring that they knew where to go. “Yep, I’m the crazy welcome guy,” said DiTroia, pausing just briefly before he extended a handshake and hello to a parent in the driver’s seat. Fellow Orientation staff dubbed him the “super greeter.” Just before the rain came, President Ronald J. Daniels and Susan Boswell, dean of student life, joined the Move-In proceedings. On his first Move-In day, Daniels charmed parents with small talk as they waited for

Related Web sites Ruth Faden:

http://faculty.jhsph.edu/Default .cfm?faculty_id=210

Johns Hopkins Quality and Safety Research Group:

www.safetyresearch.jhu.edu/QSR/ index.asp

Peter Pronovost:

www.hopkinsmedicine.org/ anesthesiology/Team/summaries/ Pronovost_Peter_bio.cfm

About the Class of 2013 • Total freshman enrollment: 1,350 • Number of freshman applicants: 16,124 • Number of freshmen admitted: 4,317 • Early decision: 504 • Underrepresented minority students: 175 • Male: 53 percent • Female: 47 percent • Krieger School of Arts and Sciences: 65 percent • Whiting School of Engineering: 35 percent • Top five states, in order: New York,

New Jersey, Maryland, California, Pennsylvania • Mean SAT I combined score: 1,395 • Mean unweighted academic GPA: 3.68 • The Class of 2013’s 14 Baltimore Scholars (graduates of Baltimore City public schools accepted into the university’s undergraduate programs who receive full-tuition scholarships) are from the neighborhoods of Fairmont, Guilford (2), Hamilton, Homeland, Lauraville, Loch Raven, Locust Point, Mount Washington, North Harford, Rosemont, Tuscany/Canterbury, Walterson and Wyman Park. Forty-three percent are underrepresented minorities.

August 31, 2009 • THE GAZETTE

R E S E A R C H

Computational process zones in on top genetic cancer suspects By Phil Sneiderman

Homewood

Related Web sites Rachel Karchin’s lab:

http://karchinlab.org

Department of Biomedical Engineering:

www.bme.jhu.edu

Johns Hopkins Institute for Computational Medicine:

www.icm.jhu.edu

Johns Hopkins Kimmel Cancer Center:

www.hopkinskimmelcancercenter .org

HIPS / WILL KIRK

ohns Hopkins engineers have devised innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer. The goal is to provide critical help to researchers who are poring over numerous newly discovered gene mutations, many of which are harmless or have no connection to cancer. According to its inventors, the new software will enable these scientists to focus more of their attention on the mutations most likely to trigger tumors. A description of the method and details of a test using it on brain cancer DNA were published in the Aug. 15 issue of the journal Cancer Research. The new process focuses on missense mutations, meaning protein sequences that each possess a single tiny variation from the normal pattern. A small percentage of these genetic errors can reduce the activity of proteins that usually suppress tumors or hyperactivate proteins that make it easier for tumors to grow, thereby allowing cancer to develop and spread. But finding these genetic offenders can be difficult. “It’s very expensive and time-consuming to test a huge number of gene mutations,

Rachel Karchin, foreground, and Hannah Carter

trying to find the few that have a solid link to cancer,” said Rachel Karchin, an assistant professor of biomedical engineering who supervised the development of the computational sorting approach. “Our new screening system should dramatically speed up efforts to identify genetic cancer risk factors and help find new targets for cancer-fighting medications.” The new computational method is called CHASM, short for Cancer-specific Highthroughput Annotation of Somatic Mutations. Developing this system required a partnership of researchers from diverse disciplines. Karchin and doctoral student Hannah Carter drew on their skills as members of the university’s Institute for Computational Medicine, which uses powerful information management and computing technologies to address important health problems, and collaborated with leading Johns Hopkins cancer and biostatistics experts from the schools of Medicine and Public Health and the Kimmel Cancer Center. The team first narrowed the field of about 600 potential brain cancer culprits using a computational method that would sort these

mutations into “drivers” and “passengers.” Driver mutations are those that initiate or promote the growth of tumors. Passenger mutations are those that are present when a tumor forms but appear to play no role in its formation or growth. In other words, the passenger mutations are only along for the ride. To prepare for the sorting, the researchers used a machine-learning technique in which about 50 characteristics or properties associated with cancer-causing mutations were given numerical values and programmed into the system. Karchin and Carter then employed a math technique called a Random Forest classifier to help separate and rank the drivers and the passengers. In this step, 500 computational “decision trees” considered each mutation to decide whether 09-06179 Hopkins Ad:Layout 1

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it possessed the key characteristics associated with promoting cancer. Eventually, each “tree” cast a vote: Was the gene a driver or a passenger? “It’s a little like the children’s game of ‘Guess Who,’ where you ask a series of yes or no questions to eliminate certain people until you narrow it down to a few remaining suspects,” said Carter, who earned her undergraduate and master’s degrees at the University of Louisville and served as lead author of the Cancer Research paper. “In this case, the decision trees asked questions to figure out which mutations were most likely to be implicated in cancer.” The election results—such as how many driver votes a mutation received—were used to produce a ranking. The genetic errors that collected the most driver votes wound up at the top of the list. The ones with the most passenger votes were placed at the bottom. With a list like this in hand, the software developers said, cancer researchers can direct more of their time and energy to the mutations at the top of the rankings. Karchin and Carter plan to post their system on the Web and will allow researchers worldwide to use it freely to prioritize their studies. Because different genetic characteristics are associated with different types of cancers, they said the method can easily be adapted to rank the mutations that may be linked to different forms of the disease, such as breast cancer or lung cancer. In addition to Karchin and Carter, the Johns Hopkins co-authors of the Cancer Research paper were Sining Chen, Leyla Isik, Svitlana Tyekucheva, Victor E. Velculescu, Kenneth W. Kinzler and Bert Vogelstein. Funding for the research was provided by the National Cancer Institute, Susan G. Komen Foundation, Virginia and D.K. Ludwig Fund for Cancer Research and National Institutes of Health. 1:39 PM

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LINGER NO LONGER

Institute for Global Tobacco Control graduates first class By Tim Parsons

School of Public Health

he Institute for Global Tobacco Control has graduated its first class of 11 international students in its Global Tobacco Control Certificate Program, one of the first academic training programs of its kind worldwide. The IGTC, located at the Johns Hopkins Bloomberg School of Public Health, launched the program in 2008 to provide international professionals and research scientists with formal academic training in global tobacco control. Completion of the program results in an official certificate and transcript with academic credit from the Bloomberg School of Public Health. The program is funded by the New York–based Bloomberg Initiative to Reduce Tobacco Use. “In order to slow and ultimately end the global burden of tobacco-related death and disease, public health professionals need to be equipped with the technical skills necessary to advance global tobacco control efforts,” said David R. Holtgrave, director of IGTC and professor and chair of the Bloomberg School’s Department of Health, Behavior and Society. “Our certificate program makes it possible for professionals from

around the globe to receive this rigorous academic training.” This year’s graduates included students from Nigeria, Uruguay, Guyana, the Philippines, India, Vietnam, China, Thailand and Poland. Many of the graduates serve as doctors, researchers, academic professors, chief medical officers and epidemiologists. The one-year program has a comprehensive plan of study that includes Global Tobacco Control, Advanced Methods in Tobacco Control, Strategic Leadership Principles, Health Communications Programs and Principles of Epidemiology. Participants complete two eight-week online courses and travel to Baltimore for three courses at the Graduate Summer Institute of Epidemiology and Biostatistics. The program is geared toward professionals who will return to their countries and provide the technical expertise needed to guide national policy. Tuition, travel and expenses are covered by scholarship. The certificate program is part of a broader effort by the IGTC to build tobacco control capacity in low- and middle-income countries. IGTC, founded a decade ago, is a World Health Organization Collaborating Centre. In 2006, under the Bloomberg Initiative, the IGTC was named to spearhead capacity-building activities in 15 priority countries, including China and India.

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8 THE GAZETTE • August 31, 2009

Common sleeping disorder ups chances of dying for snorers B y D av i d M a r c h

Johns Hopkins Medicine

ightly bouts of interrupted, oxygendeprived sleep from a collapsed airway in the upper neck raise the chances of dying in middle-aged to elderly people by as much as 46 percent in the most severe cases, according to a landmark study on sleep apnea by lung experts at Johns Hopkins and six other U.S. medical centers. Even in people with moderate forms of the sleeping disorder, with anywhere from

Related Web sites Naresh Punjabi:

www.hopkinsmedicine.org/ pulmonary/faculty/division_faculty/ punjabi_nm.html

Sleep Heart Health Study:

www.jhucct.com/shhs

‘PLoS Medicine’:

www.plosmedicine.org/article/ browseIssue.action

15 to 30 episodes of interrupted breathing during each hour of supposed rest, risk of death jumps 17 percent. The ongoing study is believed to be the largest ever conducted into sleep and related illnesses, with the latest report taking more than a decade to complete. The study involves some 6,441 men and women, between ages 40 and 70, with mild to severe forms of sleep apnea or none at all. Many are self-described snorers; snoring is a key symptom of sleep apnea. Though anecdotal reports and medical record searches have long hinted at the connection between sleep problems and death,

especially from heart disease, the latest study is the first to define death from sleep apnea by monitoring a large number of people with or without the sleeping condition, including a high proportion of snorers, to see who dies and who does not. Some 1,047 deaths occurred among study participants since the clinical investigation began. It is estimated that 24 percent of American men and 9 percent of women have irregular breathing patterns during sleep, with four in five unaware that they have a problem. As part of the so-called Sleep Heart Health Study, researchers at Johns Hopkins Bayview Medical Center monitored study participants’ sleep patterns at home for at least one full night’s sleep, which averaged about seven hours. More than 50 study technicians were needed to handle the nearly 10,000 detailed recordings of participants’ breathing patterns, heart rhythms and brain activity made to date. About half of the participants were found to have moderate to severe sleep apnea, and they were tracked through annual clinic visits to gauge any sickness or death from high blood pressure, heart disease or stroke. Reporting in the Public Library of Science, Medicine, online Aug. 18, researchers found that as little as 11 minutes a night—just 2 percent of an average night’s sleep of seven hours—spent in severe sleep apnea and with subsequent oxygen deprivation, in which blood oxygen levels drop below 90 percent, doubled the death rate in men. Women in the study who died and had had severe sleep apnea were too few for researchers to draw a similar conclusion at this stage in the study, but researchers suspect that further research will bear the same results. “Our study results really raise concern about the potentially harmful effects of sleep apnea,” said pulmonologist and study site principal investigator Naresh Punjabi, an associate professor at the Johns Hopkins School of Medicine. Low blood oxygen

levels during sleep are “a particularly worrisome sign,” he added, citing the factor as the single biggest predictor of death in people with sleeping disorders. “Such an increased risk of death warrants screening for sleep apnea as part of routine health care, in which all physicians should inquire about patients’ sleeping habits, including symptoms of feeling tired or drowsy during the daytime, poor nighttime sleep quality, recurrent awakenings from sleep and reports from your bed partner that you snore loudly or intermittently stop breathing during the night,” Punjabi said. Given how widespread sleep apnea is, he says, this information is relatively easy to acquire and is essential for medical scientists to identify which, if any, particular treatments work at curing the illness by ultimately lowering the number of chronic medical conditions and premature deaths caused by it. Key among such treatments is use of overnight sleeping aids, such as the CPAP (continuous positive airway pressure) device. The device, which resembles an oxygen mask, is worn over the nose and connected

European REACH legislation may require more animals, funds By Tim Parsons

School of Public Health

he European Union’s REACH (Registration, Evaluation, Authorization and restriction of CHemical substances) legislation is intended as a comprehensive safety evaluation for commercial

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by a thin tube to a machine that forces air into the nasal passages, preventing the airways from collapsing. “Our goal is to achieve normal breathing patterns during sleep and maintain blood oxygen levels as close to normal as possible,” said Punjabi, who points out that the medical standard is to always maintain blood oxygen levels in the range of 95 percent or above. Punjabi says that the study team’s next steps are to separate causes of death due to sleep apnea; in particular, to define the added risk from heart disease or stroke. Funding support for the study was provided by the National Heart, Lung and Blood Institute. In addition to Punjabi, Johns Hopkins researchers involved in the study were Brian Caffo, Philip Smith, Moyses Szkio and Melissa Minotti. Johns Hopkins was also the data-coordinating center for the Sleep Heart Health Study, with additional research assistance provided by Marie Diener-West, John Dodge, Michele Donithan, Charlene Levine, Curtis Meinhart, Nancy Min, Michael Smith, Andrea Tibbs, James Tonascia, Linda Roberts and Jill Meinert.

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chemicals used in consumer products that are traded in Europe at amounts more than one ton per year. However, implementation of the regulation may require 54 million research animals and 9.5 billion euros ($13.4 billion) over the next 10 years—20 times the number of animals and six times the cost anticipated in previous estimates, according to an analysis led by researchers at the Johns Hopkins Bloomberg School of Public Health. Currently, the EU uses approximately 900,000 animals at a cost of 600 million euros ($847 million) per year to evaluate new chemicals, drugs, pesticides and food additives. A commentary on the research is published in the Aug. 26 edition of Nature. The full analysis will appear the same day as an electronic pre-publication of the September edition of the journal ALTEX, Alternatives to Animal Experimentation. “As a toxicologist, I support the aims of REACH. It is the biggest investment into consumer safety ever,” said study author Thomas Hartung, the Doerenkamp-Zbinden Professor and Chair for Evidence-based Toxicology and director of the Center for Alternatives to Animal Testing at the Bloomberg School. “However, I am concerned that we have underestimated the scale of the challenge. Investment into developing alternative research methods to meet REACH goals is urgently needed.” According to Hartung and co-author Constanza Rovida, estimates for the number of chemicals to be covered by REACH range from 68,000 to 101,000, higher than the earlier estimate of 29,000. The analysis was based on the conservative estimate of 68,000 registered chemicals. Results showed that 90 percent of the projected animal use and 70 percent of the projected cost would come from research into reproductive toxicity testing. This often requires that data be collected from two species of test animals and their offspring. The U.S. Environmental Protection Agency regulations do not include two-species provisions. “A revision of test approaches, especially for reproductive toxicity, is essential. There is no alternative to REACH, but there will be no REACH without alternatives,” Hartung said. Further discussions of REACH and alternative testing methods will be addressed at the 7th World Congress on Alternatives & Animal Use in the Life Sciences, taking place from Aug. 30 to Sept. 3 in Rome. Funding for the research was provided by the Transatlantic Think Tank for Toxicology.

August 31, 2009 • THE GAZETTE

APL, Homeland Security developing next public alert system B y P a u l e tt e C a m pb e l l

Applied Physics Laboratory

ngineers in APL’s Infocentric Operations Business Area are helping the Department of Homeland Security create a national next-generation emergency alert system that will work across multiple platforms, including television, cell phones and the Web. The current Emergency Alert System was created in the 1950s to warn Americans of nuclear attacks. The technology used to alert the public today—television, radio, newspapers and, more recently, the Internet—is still pretty much “last century.” For imminent emergencies, the method is even more outdated: Remember that “beep, beep, beep” broadcast on television and radio stations? Hurricane Katrina and the Sept. 11 terrorist attacks underscored the vulnerability of America’s emergency response system. In particular, Katrina severely tested the reliability of the communications infrastructure in the Gulf Coast region, crippling television broadcasts, cable TV and phone service

and even the generally resilient public safety networks. Media consumption patterns have changed, notes APL’s Tammy Parsons, the project manager for the alert-system work. “As connected mobile devices such as cell phones and PDAs become ever-present, and as the lessons of recent disasters take root, the government is rethinking the shape of the emergency alert system, and APL is playing an integral role in that effort,” she said. Under a 2006 executive order signed by then President George W. Bush, the Federal Emergency Management Agency began developing the Integrated Public Alert and Warning System, or IPAWS. “IPAWS is a major systems engineering challenge, as multiple systems—some existing and some still being defined— must be integrated to meet the needs of the president and all levels of government emergency managers,” said APL’s Wayne Buhrman, who did significant up-front work analyzing both the current system and commercially available options. IPAWS consists of several components, including the next generation of the EmerH O P K I N S

gency Alert System, providing voice, video and data messages in a standard digital format over Web-based networks; a 24-hour private telephone system at 2,200 sites across the country used to convey warnings to federal, state and local governments; and the Commercial Mobile Alert System, or CMAS, a mobile device alerting system created by the Warning, Alert and Response Network Act of 2006. Working with Homeland Security’s Directorate for Science and Technology and FEMA, APL is developing requirements and analyzing potential solutions for systems that will round out the IPAWS capabilities. Eventually, the president, as well as state, local and tribal emergency managers, will be able to address the public over multiple media: radio, cable television, pagers, cell phones, the Internet and as many other outlets as feasible. “Our current system relies largely on radio and television, but on average Americans only spend 12 percent of their day listening to the radio and 31 percent watching television,” Parsons said. “But 84 percent of Americans have cell phones.” CMAS, she added, will enable mobile service providers

to voluntarily transmit alert and warning information to their subscribers. APL is also working with the joint task force of the Alliance for Telecommunications Industry Solutions and Telecommunications Industry Association to define the requirements for the interface between the FEMAadministered CMAS entities and the equipment from mobile service providers. “The mutual agreement on interface requirements by the government and wireless industry is paramount to the systems’ success and has been largely successful to date,” said Gina Marshall-Johnson, who is working on a team developing security requirements for CMAS. Denis Gusty, the program manager for emergency alerts in the DHS Science and Technology Command, Control and Interoperability Division, said, “The work that we are doing with APL and FEMA is critical to the future of emergency alerting. [These evolving systems] are integral components in improving the capabilities of emergency alerting systems and ultimately keeping our nation safe.” This article appeared previously in APL News.

H I S T O R Y

The Camera Club victory By Ross Jones

Special to The Gazette

hen Johns Hopkins students decide something needs to be done, usually they find a way to do it, even if that might mean bribing a senior officer of the university. Consider the case of the Camera Club, a student-run group organized in the midThis is part of an occasional series of historical pieces by Ross Jones, vice president and secretary emeritus of the university. A 1953 graduate of Johns Hopkins, he returned in 1961 as assistant to president Milton S. Eisenhower and was a close aide to six of the university’s 13 presidents.

Controller Continued from page 1 that he was a favorite with Hopkins made his candidacy appealing.” Oler said that he is both excited and overwhelmed by his new job. “The size and complexity of Johns Hopkins, as well as the dedication and excellence of its employees, are staggering,” Oler said. “To be selected controller of such a fantastic and dynamic organization is an honor and a privilege.” Oler’s promotion comes as the university’s Office of Finance and Administration continues to reorganize in the wake of tight economic times. In addition to Oler’s promotion, Strine has assumed a new role as university treasurer. He takes over that position from Art Roos, who, in the nearly three years that he held the post, strengthened the capacity of the Treasurer’s Office and provided critical services in investing, banking, and debt and risk management, Strine said. Strine credits Roos with, among other things, affirming the university’s strong credit ratings and providing critical services in investing, banking, and debt and risk management. Roos recently left the university to pursue other projects. Strine said that streamlining the Finance and Administration Office will allow the university to continue to deliver high-quality services in a more effective and efficient way while maintaining service levels. Tahey, who agreed to take on the controller position for three years but stayed for nearly

1930s. The students enjoyed taking pictures, but they had no place for club meetings or, more important, no place for a darkroom where they could develop and print their photographs. They combed the Homewood campus and discovered that the Gatehouse, at the corner of Charles Street and Art Museum Drive, was empty. It had been used as a laboratory by “gas engineers” in the School of Engineering, but it was unlikely that they would use it again. (The small stone building, now the home of the undergraduate newspaper, The NewsLetter, was the gatehouse for the Wyman family’s Homewood Villa, an ornate Victorian residence that stood, until the late 1950s, just southwest of where Garland Hall is today.) The building was in poor condition. All the windows had been knocked out, and the

roof was described as “falling off.” But with modest renovations, it could become the perfect home for the Camera Club. What could the club do to get use of the building? First, Sara Elizabeth Freeman, the graduate-student secretary of the club, wrote to P. Stewart Macaulay, then secretary of the university and later provost and executive vice president. She noted that the building was not occupied and that eventually it would have to be repaired. Why not fix it now and make it available to the Camera Club? Five days later, on Nov. 18, 1937, Freeman sent another letter to Macaulay, this time to inform him that club members had unanimously voted to elect him “to honorary membership in the Johns Hopkins Photographic Society.” (Perhaps the university secretary would be more inclined to accept

membership from a society rather than a club?). Macaulay thanked the students and accepted their invitation. He added, “Obviously, none of the members has seen any of my photographic efforts.” Writing to President Isaiah Bowman about the Gatehouse on Nov. 26, in a letter now in the Hamburger Archives of the Eisenhower Library, Macaulay said, “It seems to me something should be done to make the place more presentable.” He said it would be a good site for the Camera Club, and he recommended an expenditure of $2,000 for repairs. He concluded, “The Camera Club is anxious to obtain quarters, and I have a selfish reason for wanting to help.” The students had made a wise choice in their selection of P. Stewart Macaulay as an honorary member.

four, was much more than the keeper of the books, according to Jim McGill, senior vice president for finance and administration. He was a major contributor to the implementation and stabilization of the SAP software system now used throughout Johns Hopkins, and he dealt with a number of changes in federal accounting rules as he worked to keep the university in compliance, McGill said. Both McGill and Strine praised Tahey and Roos for their service to the university. “We appreciate deeply their contributions to Hopkins,” McGill said. Looking ahead, Oler, in his new job, will

work with fellow university administration members to continue efforts to deliver quality in a more streamlined capacity. Oler already has a running start. Before joining the university 16 years ago, he was employed by the international professional services firm KPMG Peat Marwick in Baltimore, where he spent nine years working on the JHU audit, including a period of time as its director. Oler also worked with a venture capital–backed software firm and with Marriott International, both in Montgomery County, Md. Oler also brings to the table a successful relationship with the financial leaders in

each of the university’s divisions, a relationship that both McGill and Strine said they consider critical to the university’s financial health. “Nothing is more important to the controller’s success than maintaining relationships with those [the office] serves throughout the divisions, central administration, the health system, trustees and outside auditors,” Strine said. He added that his team’s highest priority will be to build on those relationships by listening to those entities’ needs and working to align the university and its priorities with the people it serves.” G

SPECTRUM 1-16 GAZETTE 8-08:Layout 2

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10 THE GAZETTE • August 31, 2009 P O S T I N G S

B U L L E T I N

Job Opportunities

English as a Second Language — ESL

The Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

Homewood

Office of Human Resources: Suite W600, Wyman Bldg., 410-516-8048 JOB#

POSITION

40216 40297 40319 40326 40396 40452 40455 40465 40467 40476 40498 40500 40542 40552 40557 40661

Tutor Training Specialist Financial Manager LAN Administrator III IT Manager Instructional Facilitator Organizational Facilitator Associate Registrar Registrar Language and Literary Tester Security Officer II Campus Police Officer LAN Administrator Instructional Facilitator HR Coordinator Financial Aid Administrator

Schools of Public H e a l t h a n d N u r s i n g Office of Human Resources: 2021 East Monument St., 410-955-3006 JOB#

POSITION

40416 40800 39780 39607 40472 40869 39424 40586 40400 40889 39387 38979 40334 40046 40192

Community Health Worker Teaching Assistant Sr. Technical Writer Sr. Research Program Coordinator II Financial Manager Community and Youth Coordinator Sr. Research Nurse Project Director, Research 2 Prevention Multi-Technical Supervisor Program Coordinator Administrator Research Specialist A/V Technician Research Aide Administrative Coordinator

School of Medicine

Office of Human Resources:

98 N. Broadway, 3rd floor, 410-955-2990 JOB#

POSITION

38035 35677 30501

Assistant Administrator Sr. Financial Analyst Nurse Midwife

at JHU, an English as a Second Language program for professionals, has extended registration for its fall evening classes at the Homewood campus. Scheduled to run from Sept. 1 to Dec. 7 are Intermediate and

40662 40666 40692 40699 40721 40726 40736 40738 40740 40814 40856 40859 40883 40904 40906 40907 40915 40930 40963

Academic Services Specialist Director, Development Lieutenant Administrative Services Software Engineer Campus Police Investigator Development Officer Academic Program Manager Custodian Sr. Technical Adviser Network Analyst Human Resources Services Supervisor Sr. Design and Construction Project Manager DE Instructor, CTY Sr. Administrative Manager Research Analyst Science Writer Academic Services Assistant Sr. Accountant Librarian II

40261 38762 38680 40665 37783 39308 40122 39306 39296 39507 40045 40275 39977 40758 40328 38840 40773 40772 39018 38886 40639 40706 39714 39063 40602

Office Clerk Resident Adviser Research Nurse Administrative Coordinator Nutrition Technician Software Engineer Research Data Coordinator Programmer Analyst Data Assistant Operations Manager Research Aide K4H Toolkit Coordinator Budget Analyst Physician Assistant YAC Co-Facilitator Communications Specialist Sr. Research Assistant Video Production Coordinator Research Program Assistant Research Assistant Web Programmer Health Educator II Dietitian Research Assistant Multimedia Technician

Nonsmoker wanted for furn’d BR and priv BA in 3BR house in Carney area, share w/M grad student. $600/mo incl utils. 443-850-3520 or 410-882-7937.

22150 38064 37442 37260 38008 36886 37890 37901

Physician Assistant Administrative Specialist Sr. Administrative Coordinator Sr. Administrative Coordinator Sponsored Project Specialist Program Administrator Sr. Research Program Coordinator Casting Technician

’95 Toyota Camry LE, white, 4-cyl, 1 owner, power everything, looks and runs great, $2,495; ’01 Toyota Corolla CE, silver, looks and runs great, 99K mi. $3,500. nagee786@yahoo.com.

This is a partial listing of jobs currently available. A complete list with descriptions can be found on the Web at jobs.jhu.edu.

Convenient.

Notices

Smart.

Classifieds

Classy and spacious meeting rooms, delicious menus, revitalizing breaks and deluxe accommodations for overnight attendees are just a few of the features we've put together for your event.

4 W E S T U N I V E R S I T Y P K W Y • B A L T I M O R E , M A R Y L A N D • 4 10 . 2 35 . 5 4 0 0 W W W. C O L O N N A D E B A L T I M O R E . C O M

sleigh glider rocker and ottoman, white, $75. 410-825-0851.

Continued from page 11 Rm at JHMI campus, walk to any bldg/shopping/transportation, free W/D and Internet, share w/JHU students, safe. $375/mo + 1/5 utils (based on 1-yr lease) or add $50 for month-tomonth lease. happyhut4u@yahoo.com.

Sofa, tan/green plaid, 3-seater, $100; recliner, $50; loveseat, white, $100; entertainment center, $100; card table w/chairs, $30; dining rm set, dishes for 8, Farberware pots, pyrex dishes, cooking utensils. Mark or Linda, 410-484-4015, 410-456-6435 or teabeary10@comcast.net.

Two rms avail in 4BR house nr Homewood campus, 2 full BAs. 443-742-4465. Rms avail in new TH, no smoking/no pets, walking distance to JHMC. $500/mo + 1/3 utils. 301-717-4217 or xiaoningzhao@gmail.com. Rm avail in 3BR Owings Mills TH, 2 mi to metro. $550/mo incl utils. jsethi33@yahoo.com.

Share 3BR, 2.5BA penthouse apt in Hampden, off the Avenue, W/D, CAC, lg kitchen, deck. $770/mo + utils + sec dep ($765). 443-9041651 or janineers19@yahoo.com. Furn’d BR/BA in 3BR Carney house, laundry on premises, share w/young M prof’l, Verizon Fios cable/Internet, short-term only. $550/mo + sec dep. Teresa, 443-850-3520 or teresatufano@ gmail.com. Share single-family house w/busy prof’l, lg yd, cable, Internet, W/D, prkng, nr JHU shuttle/ YMCA/shopping, dogs OK. $650/mo incl utils. 410-952-2153. F wanted to share peaceful, furn’d 3BR, 2BA house, short-term lease OK. $550/mo incl wireless, utils and prkng. skbzok@verizon.net.

CARS FOR SALE

’96 Saturn SL2, automatic, gray, 4-dr, wellmaintained, new tires, reliable, runs great, 106K mi. $2,000. 410-499-3163 or stu_merkel@ yahoo.com.

Beach chairs (2), digital piano, reciprocating saw, 3-step ladder, stool, chair, computer, printer, microwave. 410-455-5858 or iricse.its@ verizon.net. Pavilion seats (4) for Jimmy Buffet show, September 3 at Nissan Pavilion. $149/ea (less than face value). kgerontakos@hotmail.com. Hoover Wind Tunnel 2 vacuum cleaner w/bags, rated #1 by Consumer Reports. 410-467-5636 or chazmeyers47@hotmail.com. Timbernest loft twin bed, high-quality, 2 yrs old, needs mattress, buyer must pick up (bed will be disassembled). $150. Carol, 443-3868477 or geedle@verizon.net.

SERVICES/ITEMS OFFERED OR WANTED F in need of housing for spring 2010, nr E Baltimore or Bayview campuses. 334-559-0085 or flemike@auburn.edu. Stay-at-home mom will care for 10- to 26-moold children, FT/PT, Mon-Fri, nr Homewood, 8 yrs’ classroom experience. 410-371-8185. Nanny avail for FT work, 10 yrs’+ experience caring for Hopkins physicians’ children, refs avail on request. 410-523-1226. Horse boarding in Worthington Valley, beautiful trails from farm, 20 mins from JHU. $500/ mo (stall board) or $250/mo (field board). argye.hillis@gmail.com. Wanted: Tutor to help me prepare to take GMATs. John, 607-592-3444. Virus trouble? Slow computer? Forget the Geek Squad, get Microsoft certified assistance. $30/ half-hr. matthewchin@gmail.com. PT care for elderly or disabled, lt housework and errands, wknds/eves, Baltimore and Harford counties. 410-299-3973.

’94 Honda Civic DX, dk pink, never any trouble. $1,200/best offer. 410-889-2830 or dr.kkamaraj@gmail.com.

Afterschool care needed for 4.5-yr-old boy who attends Wolfe St Academy, Mon-Fri, 2:305:30pm. natalia.lapshina@gmail.com.

’03 PT Cruiser, AC, CD player, power windows, Md insp’d, beautiful cond, 58K mi. 443350-2192.

Current JHU grad student looking for language exchange/tutoring from native Thai speaker. travelbug637@gmail.com (for details).

’85 Westfalia pop-top camper van, great body and interior, needs head gasket, pics avail. $2,000/best offer. sullivan235@comcast .net.

Key’s Cleaning Services, great rates, discounts, trustworthy, honest and reliable, the key to all your cleaning needs. kyn_jones@yahoo.com. Need a website? Need your site maintained? pizzaL@comcast.net.

ITEMS FOR SALE Moving sale: “The First Year” bottle warmer, new, used a few times, w/box and manual. $15. 443-722-9066 or caroline.redheuil@gmail.com. Alto sax, mint cond. $650/best offer. 410-4881886. Ikea “Sultan” queen bed and mattress, $200; Ikea “Varnamo” sofa, brown, $200; Sharp 32” flatscreen LCD HDTV w/stand, $350. 612208-5035 or ranganathan_balu@yahoo.com. Moving sale: all household items and furniture; good stuff, everything must go. 443-528-3637.

A DoubleTree Hotel

Advanced Oral Communication, Monday and Wednesday, 6 to 7:30 p.m.; Intermediate Academic and Professional Writing, Tuesday, 6 to 9 p.m.; and Advanced Academic and Professional Writing, Thursday, 6 to 9 p.m. The fall term begins with placement testing from 6 to 8 p.m. on Tuesday, Sept. 1. Classes begin Wednesday, Sept. 2. For more information or to register, go to www.ltc.jhu.edu/esl, e-mail esl@jhu.edu or call 410-516-5431.

Solar attic fan. $400. jodytom@yahoo.com or http://solaratticfansource.com/product_info .php?cPath=1&products_id=23 (for example).

Affordable

Meet with success.

B O A R D

Wood/steel dining table w/4 chairs, $90; desk chair, $30; microwave, $30; custom-fit infant gate, $55. Julia, 443-824-0190. Pottery Barn-style dresser, solid wood, $80;

Guitar lessons w/experienced teacher, beginner through advanced, many styles taught; will travel. Joe, 410-215-0693. T’ai chi beginner classes, start Wed, Sept 23, in Charles Village (7:45-8:45pm) or Tues, Sept 22, in Towson (6:45-7:45pm). 410-296-4944. PT nanny, infant-qualified, experienced w/all ages, CPR/first-aid training, refs avail. 443-4690972 or chessline.solomons@gmail.com. Affordable landscaper/certified horticulturist can maintain existing gardens, also design, plantings, masonry; free consultations. 410683-7373 or grogan.family@hotmail.com. Tutor avail: all subjects/levels; remedial, gifted and talented; also college counseling, speech and essay writing, editing, proofreading. 410337-9877 or i1__@hotmail.com.

August 31, 2009 â&#x20AC;˘ THE GAZETTE

Classifieds

M A R K E T P L A C E

Gulf Coast (Holiday, Florida), 2BR, 2BA single-family waterfront house, sleeps 6, pet- and smoke-free. 410-446-1904 (general questions), 410-446-1903 (for reservations) or go to www .wittpiersstarisland.com.

APARTMENTS/HOUSES FOR RENT

W/D, AC units, fp, hdwd flrs, yd, prkng. $1,350/mo + utils. szieman1@hotmail.com.

Lauraville, spacious 2BR, 1BA apt, 2nd flr, renovâ&#x20AC;&#x2122;d kitchen, new paint, W/D, mins to JHH, access to yd and garage. $725/mo. 410236-4236.

Baltimore Co (Middlesex), lg 3BR, 1.5BA TH, CAC, finâ&#x20AC;&#x2122;d bsmt, must have very good credit. $1,100/mo + sec dep. 443-528-5024.

Charles Village, 4BR house, completely furnâ&#x20AC;&#x2122;d, remodeled kitchen, 3 decks, close to everything. $2,500/mo. Christopher, 410-336-2172.

Mt Vernon, 2BR apt, 3rd flr, living rm, dining rm, AC, W/D, prkng, nr JHU shuttle/MTA, avail 9/1. $1,150/mo. 410-591-2611.

Bayview area, 2BR apt, 1st flr, W/D, no pets; rent + sec dep + utils. Elaine, 410-633-4750.

Charles Village (University One), 2BR, 2BA condo, spacious, clean, sunny, balcony, exercise rm, pool in bldg, JHU shuttle right outside, all utils inclâ&#x20AC;&#x2122;d. uni1condo@hotmail.com.

Mt Washington, 2BR, 2BA apt, 2nd flr, W/D, assigned prkng, pool. $1,150/mo + utils. Julia, 410-336-3966 or jtchoi@gmail.com.

Berlin, Germany, spacious 2BR apt in multicultural neighborhood, living rm, full kitchen and BA, well connected to shopping/public transport. 760 euros/mo incl utils. 410-2438113. Butchers Hill RH, 1BR + office, fully furnâ&#x20AC;&#x2122;d, all appls, wireless, satellite TV, sec sys, conv to JHMI, academic or 1-yr lease. $1,150/mo. dsscc2009@yahoo.com.

Charles Village, 1BR and studio w/hdwd flrs, lots of light, W/D, on shuttle route. 410-383-2876. Sublet: 1BR, 1BA in St Paul Court Apts, living rm, dining rm, kitchen, across from Bank America/Eddieâ&#x20AC;&#x2122;s, avail Sept-Jan. $695/mo. 701388-4319 or abakjalpan@gmail.com.

Canton, 2BR, 1BA RH, 3-story w/loft, stainless steel appls, patio, rooftop, 1.5 blks off Square. 303-909-4958.

Cross Keys Village, 1BR condo w/hdwd flrs, CAC/heat, 24-hr security, swimming pool, free prkng. $900/mo (or option to buy). 646-2842279 or tamrirev@yahoo.com.

Canton (Lighthouse Point), 2BR, 2BA waterfront condo w/garage. $1,995/mo. sres1@ comcast.net.

Ednor Gardens, historic 3BR, 2BA house. $1,300/mo. 443-845-4613 or matthew.dagostino @gmail.com.

Cedarcroft, 3BR, 1.5BA TH, W/D, dw, fenced yd w/deck. $1,250/mo + utils. 410-378-2393.

Ednor Gardens, 3BR house, close to JHU/ YMCA/Giant, perfect for grad students and postdocs. $1,200/mo. stu_merkel@yahoo.com.

Cedarcroft, 2BR, 1.5BA Victorian, furnâ&#x20AC;&#x2122;d/ unfurnâ&#x20AC;&#x2122;d, living rm, dining rm, den, office,

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Roland Park

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Call 410-366-7441

$2100 mo. - 3 Lvl, 4 BD, 3.5BA, large open DR/LR, 2 dens, CAC, FP, carpet, W/D, fully equipped kit., large LL finished walkout. $1,900 mo. - 3BD, 2.5BA, DR, LR, den, CAC, FP, carpet, W/D, fully equipped kit. Lg. unfinished walk-out LL.

Rent In Historic 1891 Elevator Secured Bldg. Central to all Baltimore Johns Hopkins Locations! Brand New Units: Only 4 left! $1250-$1400 2 BD 2 Full BA All with full size W/D, D/W, micro., carpet, CAC, Free off-street parking. 2300 N. Calvert St. 410 .764.7776 www.BrooksManagementCompany.com

Fells Point, gorgeous 2BR, 2BA apt, 1,100 sq ft, stainless steel kitchen, dw, fp, secure entry, water view, 5-min drive to JHH, serious inquiries only, 1 secure prkng space avail at reduced fee, credit check/sec dep reqâ&#x20AC;&#x2122;d, will consider pets for additional sec dep. 703-307-4273. Glen Burnie waterfront, furnâ&#x20AC;&#x2122;d 2BR house, lg decks, pier, boat lift avail. $1,795/mo (discounted). 410-980-0686. Hampden, 1.5BR, 2BA TH w/finâ&#x20AC;&#x2122;d bsmt, W/D, CAC, walk to JHU. $1,000/mo. 410-790-1670 or ghefter@hotmail.com. Hampden, clean 3BR, 1.5BA TH, W/D, AC, storage, deck, yd, lease for 13 mos (August free). $1,400/mo. dfconsultingllc@gmail.com.

The Smith Group presents Hampden Homes! 701 West 33rd St - $237,500 3BR/2BA Det., Porch Frt, lg rms,

arch details, gas FP, rear patio. New windows. 609 West 33rd St- $229,900 - 3BR/2BA Brick, Porch Frt , wd flrs, club room. New windows/updated kitchen. 3544 Buena Vista Ave- $222,500 - 2BR/1.5BA Bow-front THS, CAC, rear deck. New windows/updated kitchen. 815 Wellington St- $219,900 - 3BR/1BA Bow-front THS, wd flrs, 4yr-roof, tiered dk. New windows/updated kitchen. 1406 Dellwood Ave- $204,000 -3BR/1.5BA semi-det. PorchFrt. wd flrs, updated electric, new windows/updated kitchen, off-st.Pkg..

Alex Smith 410-446-1180 Paul DiBari 443-610-8633 www.mysmithgroup.com, Coldwell Banker EHO

Condo Sale by Owner - 2BD/2BA, Charles Vllg/steps from JHU, shops, restaurants. Pre-war, Georgian interiors, orig. hwd flrs, molding, brick FP, euro/modern kitchen, ceramic tile floors, Zodiaq countertops/SS app., renov.BAâ&#x20AC;&#x2122;s & bonus sunroom, DR w/ french doors, foyer, new Energy windows & AC. 1 park space, security system. Call Elena: 201-213-5354 See more online:

http://web.me.com/Imsergio/ BALTIMORE SALE/Welcome .html

Mt Washington, furnâ&#x20AC;&#x2122;d 1BR, 1BA bsmt apt, sep entry, W/D, free prkng, cable/Internet, short-term OK. $850/mo + sec dep ($425). jillinyc@hotmail.com. Patterson Park, 2BR, 1.5BA house, hdwd flrs, crpt upstairs, stainless steel appls, skylight, exposâ&#x20AC;&#x2122;d brick, 1.25 mi to JHMI. $1,100/mo. 443-286-4883. Perry Hall, 3BR, 2.5BA EOG TH, CAC, all appls, hdwd flrs, master BR/BA + walk-in closet, fenced yd, patio, shed, nr 95/695, in quiet community. $1,600/mo + utils. 443-8011699 or kheld4@gmail.com. Pikesville, 1BR, 1BA apt, 1,100 sq ft, W/D, CAC/heat, dw, w/w crpt, walk-in closet, storage rm, cable- and phone-ready, gym/pool access, prkng, nr groceries/restaurants/medical and dental clinics, nr metro. $1,039/mo or 443-870-3481 or alcuasay@yahoo.com.

410-889-4157

www.baltimoreanapartments.com

Johns Hopkins / Hampden WYMAN COURT APTS. (BEECH AVE.) Effic from $570, 1 BD Apt. from $675, 2 BD from $775 HICKORY HEIGHTS APTS. (HICKORY AVE.) 2 BD units from $750 Shown by Appointment 410-764-7776 www.brooksmanagementcompany.com

Lg 3BR, 2.5BA TH close to JHH/Fells Point/ Patterson Park, CAC, W/D, dw, new crpt. $1,450/mo. 410-241-5273.

HOUSES FOR SALE Butchers Hill/Canton, newly rehabbed 2BR, 1BA TH, stainless steel appls, granite, hdwd flrs, conv to JHH. $154,900. Tracy, 443-829-5038. Hampden, totally renovâ&#x20AC;&#x2122;d 3BR, 2.5BA house w/ screened porch, fenced yd, priv prkng, walk to Homewood/shops/restaurants/grocers/theater. $310,000. 919-607-5860 or 410-962-5417. Harborview, single-family house, nr all amenities, 15 mins to E Balto campus, 5 mins to Bayview, 20 mins to Homewood campus. $168,500. 443-604-2797. Lake Walker (MSL# BA7014995), 3BR, 2BA single-family house, open flr plan, newly renovâ&#x20AC;&#x2122;d, nr Belvedere Square and Towson. $239,900. Pam, 410-532-3055. Roland Park, gorgeous 2BR co-op next to Homewood campus, short walk to JHMI shuttle. $148,000. 443-615-5190. Roland Park (â&#x20AC;&#x153;Alonsovilleâ&#x20AC;?), 6BR, 3.5BA colonial w/gourmet kitchen, CAC, huge rms, sunrm, finâ&#x20AC;&#x2122;d bsmt, in Roland Park school zone, walk to JHU. $599,000. 410-366-2166 or 429wingate.blogspot.com.

Remington, charming, furnâ&#x20AC;&#x2122;d 3BR, 1.5BA house, W/D, deck, alarm, yd, nr JHU/JHMI shuttle, no pets, avail November 1. $1,500/mo. meza.gina@gmail.com.

Wyman Park (JHU/BMA area), fully renovâ&#x20AC;&#x2122;d 3BR, 2BA TH w/hdwd flrs, CAC/heat, 2-car garage. $299,900. 410-581-4939 or syakov@ yahoo.com.

Rodgers Forge, 3BR TH w/2 full BAs, CAC, W/D, community park and gazebo, nr Baltimore County schools. $1,640/mo. dickgeorge@ comcast.net.

ROOMMATES WANTED

Towson area, 3BR, 2BA TH, CAC, W/D in finâ&#x20AC;&#x2122;d bsmt, all new windows, fenced yd, short commute to JHU/JHH, 1 min to beltway. $1,050/mo + utils. Pat or Adrienne, 410-3081291.

Share 2BR, 2BA Mt Washington apt, own BA, furnâ&#x20AC;&#x2122;d common area, CAC, W/D, free prkng. $458/mo + utils. 443-854-2303.

Upper Fells Point, updated 2BR, 2.5BA TH, 3-story, W/D, storage, huge yd, walk to JHH/ Fells Point/Patterson Park, avail September 1, 1-yr lease. $1,695/mo. Jana, 707-315-6450 or Allison, 203-500-4338. West Hampden, 3BR, 1.5BA house on quiet street, W/D, dw, CAC, hdwd flrs, front porch, ample prkng, fenced yd, pet-friendly. $1,300/ mo + sec dep. 410-340-8402.

F wanted for furnâ&#x20AC;&#x2122;d rm in bsmt of 2BR, 1BA Canton RH. $400/mo. olapshin@gmail.com.

F nonsmoker wanted for 1BR in 2BR apt on W University Pkwy, share w/F grad student, AC, heat, hot water, gas inclâ&#x20AC;&#x2122;d, no pets, 5 mins to campus, start September. $515/mo + 1/2 elec. gwxts5@gmail.com. Living or dining rm in Carlyle Apts avail, share w/2 easygoing M grad students, rent negotiable. 410-340-8327 or qianbox@gmail.com.

Furnâ&#x20AC;&#x2122;d BR w/priv BA, walk-in closet, easy access to shopping/795/695/metro station, rent incls utils, high-speed Internet. 908-487-8816.

Furnâ&#x20AC;&#x2122;d 1BR w/own BA in 3BR Fells Point apt, W/D, free Internet access, safe street, 15-min walk to SoM, compensation for monthly bus pass avail for student and postdoc. $400/mo + utils. xzhan45@gmail.com.

Lg 1BR apt in secure bldg, nr JHU and shuttle, optional prkng ($80/mo). $1,000/mo incl all utils. 443-956-2616.

F wanted to share 2BR apt in Timonium, hdwd flrs, dw, AC, walk-in closet and half-BA. $550/ mo + utils. snorfldorf@aol.com.

Fully finâ&#x20AC;&#x2122;d level w/furnâ&#x20AC;&#x2122;d BR (queen bed, nightstand, dresser, mirror, 32â&#x20AC;? TV, computer desk), 2 blks to JHH. $675/mo (incl cable, gas, electric, sec sys, water) + sec dep ($350). 404808-7990 or pritteeyez@aol.com.

Lg rm avail in Patterson Park RH, renovâ&#x20AC;&#x2122;d kitchen and BA, avail 9/1, nr JHH. $600/mo incl utils. 410-563-7558.

Highlandtown 6BD-4BA THS

Loft avail in renovâ&#x20AC;&#x2122;d Mt Vernon house, share w/2 JHU med students, great location, nr monument, easy access to JHMI shuttle/MICA/ Peabody/downtown. $500/mo. 217-898-0833 or rwsamuels@gmail.com.

Great kitchen, HWD floors, yard w/privacy fence. wired for catv, internet, phone, hook up for W/D. $1,995. 443-506-2644

Furnâ&#x20AC;&#x2122;d rm in 3BR, 2.5BA RH, 2 blks to JHH, shuttle stops in front. $500/mo incl all utils, high-speed Internet. 703-944-8782.

3917 Mt. Pleasant Ave, New RENO!

trish@cbfbrokerage.com

The Baltimorean Apartments Studio Apts. available from $800 per month including gas, water, heat and optional furniture for an 8-12 month lease term.

Historic apt, 2,000+ sq ft, newly updated, partly furnâ&#x20AC;&#x2122;d, W/D, hdwd flrs, garage, off-street prkng, walk to park, nr shops/bus/metro/I-83. $1,300/ mo + utils. Brian, 443-326-3300.

Continued on page 10

PLACING ADS Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines: â&#x20AC;˘ One ad per person per week. A new request must be submitted for each issue. â&#x20AC;˘ Ads are limited to 20 words, including phone, fax and e-mail.

â&#x20AC;˘ We cannot use Johns Hopkins business phone numbers or e-mail addresses. â&#x20AC;˘ Submissions will be condensed at the editorâ&#x20AC;&#x2122;s discretion. â&#x20AC;˘ Deadline is at noon Monday, one week prior to the edition in which the ad is to be run. â&#x20AC;˘ Real estate listings may be offered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.) Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attachments) to gazads@jhu.edu; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Baltimore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.

12 THE GAZETTE • August 31, 2009

Tales of Poe

A U G .

S E P T .

of Prior Research in Reports of Trials,” an Epidemiology thesis defense seminar with Karen Robinson. W2008 SPH. EB

Calendar F I L M / V I D EO

Poe in Motion is offered as part of Baltimore’s Nevermore 2009 Edgar Allan Poe celebration. Tickets (which include museum admission) are $6, $3 children and students, free for members. They are available in advance at www.missiontix.com or at the gate (cash only).

Milk safe, even encouraged for some kids after allergy treatment ome children with a history of severe milk allergy can safely drink milk and consume other dairy products every day, according to research led by the Johns Hopkins Children’s Center and published in the Aug. 10 online edition of the Journal of Allergy and Clinical Immunology. Investigators followed up with a subset of children who were part of an earlier Hopkins Children’s–led study published in 2008 in which patients allergic to milk were given increasingly higher doses of milk over time. For many of the children, continuous exposure to milk allergens—the proteins that trigger bad reactions—slowly and gradually retrained their immune systems to better tolerate the very food that once sent those systems into overdrive. The follow-up of 18 children ages 6 to 16 whose severe milk allergies had eased or disappeared found that all of them were able to safely consume milk at home and that reactions, while common, were generally mild and grew milder over time. The follow-up period varied from three to 17 months, depending on how long it took patients to increase their milk intake. These findings also suggest that regular use of milk and dairy foods may be needed for children to maintain their tolerance. “We now have evidence from other studies that some children once successfully treated remain allergy-free even without daily exposure, while in others the allergies return once they stop regular daily exposure to milk,” said the study’s senior investigator, Robert Wood, a professor of pediatric immunology in the School of Medicine and director of Allergy and Immunology at Hopkins Children’s. “This may mean that some patients are truly cured of their allergy, while in others the immune system adapts to regular daily exposure to milk and may, in fact, need the exposure to continue to tolerate it,” he said. After up to 17 months of at-home consumption, 13 of the 18 children who could tolerate increasingly higher doses of milk were asked to return to the clinic for tests. Of the 13, six showed no reaction after drinking 16,000 mg (16 ounces) of milk, twice the highest tolerated dose during the initial study, and seven had reactions at doses ranging from 3,000 mg to 16,000 mg. The reactions ranged from oral itch to hives, to sneezing, to mild abdominal pain, but none was serious. One child developed a cough requiring medications. Investigators also continued to follow

–

Tues., Sept. 1, 1:30 p.m. “The Citation

he elegant exterior of Evergreen’s Gilded Age mansion will take on the gloomy characteristics common in Edgar Allan Poe’s Gothic fiction at an outdoor screening on Friday, Sept. 4, of two tales from the original master of horror: The Tell-Tale Heart (1953), an Oscar-nominated animated short, and The Raven (1963), with Peter Lorre, Vincent Price and Boris Karloff as three aging wizards. Evergreen Museum & Library and its grounds will open at 5:30 p.m., and the screenings begin at 7:30 p.m. (rain location: Carriage House). Filmgoers are encouraged to arrive early and view the museum’s first-floor rooms, rare illustrated editions of Poe from the Garrett Library and Modernism at Evergreen: Erno Fabry (1906–1984), the museum’s current exhibition. Classic movie fare will be available for purchase, and picnics, beach chairs and blankets are welcome, but visitors are asked to leave dogs at home. Parents are advised to consider the subject matter of films when bringing young children.

3 1

three children who could not tolerate doses higher than 2,540 mg (2.5 ounces)—the cutoff set by the investigators at the beginning of the follow-up—which made them ineligible to continue the at-home part of the study. All three continued to drink milk daily with minimal reactions, and two of them were eventually able to increase their consumption beyond 2,540 mg. Sensitivity to milk was also measured with traditional skin prick testing, which showed gradual decreases in reactions over time. Seven children had no reactions at eight to 15 months of follow-up. Blood levels of milk IgE antibodies slowly decreased over time, too, another sign of better tolerance to milk. At the same time, a different type of antibody, IgG4—one that signals immunity to a particular allergen—went up over time, a marker of improved tolerance. Children and their parents kept daily logs of milk and dairy consumption and recorded symptoms, such as hives, abdominal pain, sneezing and cough. During the first three months, consumption of milk triggered reactions 49 percent of the time, with some children experiencing as few as two reactions for every 100 doses of milk consumed. The figure dropped to 23 percent in the subsequent three months, and some children had no reactions at all. Milk allergy is the most common type of food allergy and is experienced by 3 million children in the United States, according to the Centers for Disease Control and Prevention. Co-investigators in the study are Satya Narisety, Robert Hamilton and Elizabeth Matsui, all of Johns Hopkins; Justin Skripak, of the Mt. Sinai School of Medicine; and Pamela Steele and A. Wesley Burks, both of Duke University. The research was funded by the National Institutes of Health. Wood receives funding support from Genentech, manufacturer of Xolair, a medication for the treatment of allergic asthma. He serves on the advisory board of the Food Allergy and Anaphylaxis Network. —Katerina Pesheva

Related Web sites Robert Wood:

www.hopkinschildrens.org/ staffDetail.aspx?id=3152&terms= %40lastname_8+wood

Fri., Sept. 4, 7:30 p.m. “Poe in Motion: Cinema Under the Stars,” outdoor screening of The Tell-Tale Heart and The Raven. (See related story, this page.) $6 general admission, $3 for children and students; free for members. Grounds open for picnicking at 5:30 p.m. (Rain location: Evergreen Carriage House.) Sponsored by JHU Museums. Evergreen

L E C TURE S Tues., Sept. 1, 5:30 p.m. “Japan’s Historical General Election: Implications for U.S.-Japan Relations,” a Reischauer Center for East Asian Studies lecture by Kent Calder, SAIS; and Rust Deming, SAIS. For more information and to RSVP, call 202-663-5812 or e-mail reischauer@jhu .edu. 806 Rome Bldg. SAIS

O N G O I N G E V E N T S Saturdays, Aug. 29 through Nov. 7, 1 p.m. and 2 p.m. Historic Home-

wood Artwalk, a fun and informative 45-minute guided walking tour covering historic and artistic sites. Departs from Homewood Museum at 1 p.m., and from the Baltimore Museum of Art at 2 p.m. Admission is free, but registration is requested; e-mail homewoodmuseum@ jhu.edu or call 410-516-5589. HW OR I E N TAT I O N Tues., Sept. 1, 8:30 a.m. to 1 p.m.

TA Orientation 2009, a half-day program for all graduate and undergraduate students in KSAS or WSE who have teaching assignments for fall 2009 and/or spring 2010. Participants attend workshops directing them to available resources and introducing them to the challenges of classroom instruction. Workshops are conducted by faculty, university staff and experienced TAs. Sponsored by the TA Training Institute/Center for Educational Resources. Hodson Hall. HW

Wed., Sept. 2, 8:30 a.m. “Trials of Diet and Lifestyle Modifications: Food Fights and Other Battles,” a Center for Clinical Trials seminar with Lawrence Appel, SoM. W2030 SPH. EB Wed., Sept. 2, noon. “Predictors and Safety of Hormonal Contraceptive Use in HIV-Infected Women in Rakai, Uganda,” a Population, Family and Reproductive Health thesis defense seminar with Chelsea Polis. E4611 SPH. EB

“Mental Health Issues and Treatment of Trafficked Girls in Cambodia,” a Mental Health seminar with Judy Bass, SPH. B14B Hampton House. EB

Wed., Sept. 2, noon.

Thurs., Sept. 3, 5:15 p.m. “Religion and Science in Early Modern European Literature,” a three-part seminar series with Joachim Kupper, Freie Universitat Berlin. Open to graduate students and advanced undergrads. Sponsored by German and Romance Languages and Literatures, the Singleton Center for the Study of Premodern Europe, the Jewish Studies Program, and Evolution, Cognition and Culture. 101A Dell House. HW Fri., Sept. 4, 12:15 p.m. “Meiotic Prophase Arrest and Resumption Mouse Oocytes: A Tale of Two Pathways,” a Carnegie Institution Embryology seminar with Rachael Norris, University of Connecticut Health Center. Rose Auditorium, 3520 San Martin Drive. HW

“On the Experiential, Symbolic and Structural Forms of HIV/AIDS Related Stigma: An Exploratory Study Among Multiple Youth Populations in Delhi, India,” a Health, Behavior and Society thesis defense seminar with Devaki Nambiar. 744 Hampton House. EB

Tues., Sept. 8, 1 p.m.

SPECIAL EVENTS Fri., Sept. 4, 11 a.m. to 3 p.m. Student Job Fair, a chance to meet campus employers from Homewood, SoM and other campuses as well as area businesses. Free refreshments and great door prizes. Participants must come prepared by creating a student job application and bringing with them at least 10 copies. For more information, go to www.jhu.edu/stujob and click on the “Student Handbook” link. Sponsored by Student Employment Services. Glass Pavilion, Levering. HW

Diversity Welcome Gathering for Graduate Students. For information, contact Rita Banz (banz@ jhu.edu), call 410-516-8477 or go to www .grad.jhu.edu/student-life/orientation. A light dinner will be served. Sponsored by Homewood Graduate Affairs and Admissions Office, Black Graduate Students Association, Mentoring to Inspire Diversity in Science and Women of Whiting. Sherwood Room, Levering. HW

Fri., Sept. 4, 5 p.m.

S E M I N AR S

“Inhibition of Isopeptidase T by UBB+1,” a Biochemistry and Molecular Biology thesis defense seminar with Matthew Steele. W1214 SPH (Sheldon Hall). EB

Mon., Aug. 31, 10 a.m.

“Community Heroes Preventing Homicides in East Baltimore Using a Public Health Model,” a Graduate Seminar in Injury Research and Policy with Daniel Webster, Youth Violence Prevention Center. A Community Hero Award will be presented posthumously to Leon Faruq, director of the Safe Streets Program. His widow Noni Faruq, acting director, Safe Streets Program, will accept the award. Reception follows. Part of the series Injury and Violence Prevention: Innovative Community Research and Practice. Sponsored by Health Policy and Management. W1030 SPH. EB

Mon., August 31, 12:10 p.m.

“The Role of Lipoylation in Plasmodium falciparum Survival,” a Biochemistry and Molecular Biology thesis defense seminar with Maroya Spalding. W1214 SPH (Sheldon Hall). EB Tues., Sept. 1, 1 p.m.

W OR K S HO P S Tues., Sept. 8, 10 a.m. to noon. “Getting Started with WebCT,” introduction and overview of the application’s capabilities. Open to faculty only. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW

Calendar

Key

EB HW PCTB SoM SoN SPH WBSB

(Events are free and open to the public except where indicated.)

East Baltimore Homewood Preclinical Teaching Building

School of Medicine School of Nursing School of Public Health Wood Basic Science Building