LONE STAR SHOPPER FEBRUARY 2, 2022

FEBRUARY 2, 2022

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FEBRUARY 2, 2022

PAGE 2

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PAGE 4

FEBRUARY 2, 2022

NNew e wHope H ofor p Treating e f o r Neurodegenerative T r e a t i n g N Diseases eurod e g e nhave e rsearched ative Diseases (NAPS)—Scientists

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A The company S o l u works t i o nwith Dr. Ksenia Kastanenka of Massachusetts General Hospital—which has a long history of supporting cutting-edge research

With that all said, many people may be relieved to learn of a small Canadi.an-headquartered biotech start-up that offers new hope to tens of millions of sufferers of neurodegenerative diseases. With Phase 1 clinical trials a l r e a d y u n d e r w a y, NervGen Pharma b e l i e v e s i t ’s o n track to become a big break.through thanks to its blockbuster drug candidDr.aSilver, t e Ñrenowned N V G -spinal 2 9 1cord . injury N and V Gregenerative - 2 9 1 i smedicine a p ereptsearcher, i d e studies ( a snew m treatments a l l p rfor o. tMSe and i n )Alzheimer’s. that works by targeting the pandr oinnovation . t e i n in medical t y rresearch— osine pto hstudy o sNVG-291 p h a t in a sanimal e models s i gof Alzheimer’s disease. m a ( P T P. ) r e c e p t o r t hIt’as also t preparing b l o c tok enter s anPhase e r v1be

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repair f o l l o w. i n g i n j u r y, whether from trauma or con.ditions such as M S o r A l z h e i m e r ’s dis.ease. NervGen targets nerve cell repair, while promoting plasticity to create new neural pathways.

NVG 2 9online 1 posting is the Lead-in copy- for b r a i n c h i l d o f D r.

Jerry Silver, a renowned spinal cord injury and regenerative medicine researcher whose pioneering work addresses a diversity of conditions defined by a damaged central nervous system.

T h efeed s ecopyi n c l u d e d e Twitter generative dis. eases, spinal cord damage, stroke and traumatic brain inj u r y.

Researchers are currently conduct. ing trials in healthy volunteers.

This willtransition to Tag s twords udies for several of these medical

clinical trial for Alzheimer’s patients in 2022 following ongoing Phase 1 safety trials for the drug candidate.

An Expert’s Opinion According to NervGen’s CEO, Paul Brennan, “The multiple preclinical studies that we are conducting, as well as our planned Phase 1b study, are important milestones for our Alzheimer’s pro- Tweet This gram, which, if successful, will provide a meaningful benefit to patients and significant potential for NervGen. “What differentiates NVG-291 from other drugs in development is that it leverages multiple mechanisms for repairing nerve damage, while most others focus on a single approach. Alzheimer’s disease is a complex condition and likely caused Google Search Ad by multiple factors. We believe that a systems approach to treating the disease is an important distinction.”

Brennan adds, “All told, NVG-291’s ability to remyelinate and enhance plasticity is a one-two knockout punch for repairing a damaged central nervous system, which is the end result on a diversity of neurodegenerative diseases, as well as traumatic brain and spinal inju- Outbrain Native Ad ries. NVG-291 could herald a revolutionary new paradigm in treating all of these chronically debilitatingSage conditions. ” 105 West Street •Winnsboro, The company’s continued strides toward launching this new class of drugs offers renewed hope to millions.

Learn More For further facts on the research and clinical trials, go to www.nervgen.com.

aliments. In particular, the com. pany has stepped up its interest in NVG.291Õs ability to tackle AlzheimerÕs disease.

The company works with D r.

Kse.nia Kastanenka of Massachusetts Gen.eral HospitalÑwhich has a long history of supporting cutting-edge research and innovation in medical researchÑ to study NVG-291 in animal mode l s o f A l z h e i m e r ’s disease.

I t ’s a l s o p r e p a r i n g to enter a Phase 1b clinical trial for AlzheimerÕs patients in 2022 following ongoing Phase 1 safety trials for the drug candidate.

A n E x p e r t ’s O p i n ion According to NervGenÕs CEO, Paul Brennan, ÒThe multiple preclin-

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ical stud.ies that we are conducting, as well as our planned Phase 1b s t u d y, a r e i m p o r t ant milestones for our AlzheimerÕs pro.gram, which, if successful, will provide a meaningful benefit to patients and sig.nificant potential for NervGen. ÒWhat differentiates NVG-291 from other drugs in development is t h a t i t l e v e r. a g e s multiple mechanisms for repairing nerve damage, while most others focuson a single approach. AlzheimerÕs diseaseis a complex condition and likely caused by multiple fact o r s . We b e l i e v e that a sys.tems approach to treating the disease is animportant distinction.Ó Brennan adds, ÒAll told, NVG-

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291Õs ability to remyelinate and enhance plas.ticity is a one-two knockout punch for repairing a damaged central nervous sys.tem, which is the end r e s u l t o n a d i v e r. sity of neurodegenerative diseases, as well as traumatic brain and spinal inju.ries.

NVG-291 could herald a revolution.ary new paradigm in treating all of these chronically debilitating conditions.Ó The companyÕs continued strides toward launching this new class of drugs offers renewed hope to millions.

Learn More For further facts on the research and clinical trials, g o t o w w w. n e r v gen.com.

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How much dirt, and how much house?

Dear Dave, My wife and I own a small catering business. We have a few big corporations as clients, and our company has been very successful over the last two or three years. Now, we are planning to build a house. I was wondering what you think about how much should be spent on the land itself versus the construction of the actual house.

Lee Dear Lee, When the whole thing is done, the payment you end up with shouldn’t be more than

25% of your take-home pay on a 15-year, fixedrate loan. The ratio of land to house can vary, and that part’s up to you. If you’re buying a big piece of land, you’re probably going to have a higher ratio of land cost to home cost than if you bought a simple lot and put a really nice home there.

Generally, a standard subdivision lot is going to be around 20% of the total price. If you spend $100,000 on the lot, you’ll end up with a total project cost of about a half-million. Now, keep in mind that’s just

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a fairly standard ratio.

It’s not a rule.

The only rule here is my rule about mortgage payments. Again, no more than 25% of your take-home pay on a fixed-rate, 15-year note. Otherwise, you can end up house poor.

And when you’re house poor, it takes away your ability to save, build wealth, and give. \ Having a big house and a lot of land is cool if you can afford it, Lee. But it’s not worth it if it’s financially stressful and prevents you from living your best life!

— Dave * Dave Ramsey is a seven-time #1 national best-selling author,

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Controlling Seasonal Controlling Seasonal Diseases In Diseases InCattle Cattle

( N As P Ssomething I ) ” H e cattle r e ’s (NAPS)—Here’ ranchers s o m eknow: t h i Each n g season brings c a twith tle itrdifferent a n c hhealth e r schallenges k n o wfor: their E liveach stock, from respiratory diseases to eye and season brings with foot infections, to enteric and other sysi t infections. d i f f eButr ethere n t are solutions. health temic c h a l lWhat e n gThe e sVetfSays or their l iExplains v e s t Eric o c kMoore, , fDVM, r o m“To sucrecessfully s p i r keep a t ocattle r y healthy d i sand e aproductive ses to includes frequent monitoring and early eye and foot infectreatment. No matter what type of cattle or t i o n sis,involved, t o ethe n fundamentals t e r i c a nto d operation

other systemic infections. But there are solutions.

W h a t T h e Ve t S a y s Explains Eric Moore, DVM, “ To successfully keep cattle healthy and productive includes Early f r e qtreatment u e n t with m o nbroad-specitoring trum a n dantibiotics e a r l y helps t r ekeep a t mcattle ent. healthy year round.

No matter what type keeping cattle healthy are the same: good of cattle or operation herd management, frequent surveillance i searly, i naggressive v o l v etreatment. d , t h” e f u n and d Seasonal a m e n diseases t a l s can t o bek emore e p preing dictable c a t t land e manageable h e a l tfor h yproducers, are notes t h eDr.sMoore. a m e“Generally, : g o o dproducers herd and veterinarians will see more cases a nand a geye em e n t , in springf and reofmfoot problems q u e n and t pneumonia s u r v eini l fall l a nand ce summer spring, a n d fore aexample. r l y , But a g depending g r e s s ion ve conditions, t r e a t msome e n tother . ” systemic bacterial infections can happen almost any S e a s o n a l diseases time of year, which further complicates c a n herd b ehealth. m o” r e p r e d i c t overall a bTwo l e hard-to-prevent a n d m a ndiseases a g e acowble calf producers might see in warm weather are foot rot and pink eye. Left untreated, each can lead to more serious, chronic health problems. Fortunately, with a watchful eye and early treatment, these infections can be easily and cost-effectively managed by producers using oxytetracycline.

Two other bacterial cattle diseases that can occur are pneumonia (shipping fever) and enteritis (scours), which can be more devastating in younger cattle. When identified and treated promptly, both can be WASH WAX quickly and effectively managed.

“Bacterial diseases in cattle need to be DETAIL treated quickly and effectively with the best tools available and that are appropriate for the situation,” advises Dr. Moore.

For example, Noromycin® 300 LA from Norbrook® North America, is a fast-acting formulation of oxytetracycline that has been effectively used by ranchers for many years and is widely available through most farm and veterinary supply companies.

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for producers, notes D r . M Did o o rYou e . Know?

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Diseases In Cattle Tw o h a r d - t o - p r e v e n t d i sTwitter e a s efeed s copy c o w - c a l f producers might see aggressive i n w Early, arm w e a t h e r treatment are f o owith t r oa #broadspectrum t a n d p i n k #antibiotic eye.

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Tw o o t h e r b a c t e r i a l c a tTweet t l e Thisd i s e a s e s t h a t can occur are pneum o n i“Bacterial a ( s hdiseases i p p iinncattle g fneed e - to v e rbe) treated a nquickly d and e neffectively t e r i t i with s the best tools available and that are ( s cappropriate o u r s ) , forwtheh situation, i c h ”c advises an b e Eric mMoore, o r e DVM. devastating in younger cattle.

W hGoogle e n Search i d e nAd tified and treated p r o m p t l y, b o t h broad c a nspectrum b e antibiotic, q u i c k lcattle, y a n dranchers, e f f eherds, c t i vdisease, e l y veterinarians, manoxytetracycline, pneumonia, shipping a g efever, d . ”enteritis, scours, foot rot, pink “B a seasons cterial diseases eye, in cattle need to be t r e Outbrain a t e d Native q u i Ad ckly and effectively with the b e s t Controlling t o o l s seasonal a v a i ldiseases a b l e in / www.norbrook.com / www. a n dcattle t h a t a r e a p p romynewstouse.com priate for the situa t i o n , ” a d v i s e s D r.

Moore.”

For exmple, Noromycin® 300 LA from Norbrook® North America, is a fast-acting formulation of oxytetracycline that has been effectively used by ranchers for many years and is widely available through most farm and veterinary supply companies.

For more informat i o n v i s i t w w w. n o r brook.com.

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The Role Of Engine Air Filters

An engine filter is not the only filter in a vehicle.

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Ve h i c l e e n g i n e s i n clude complex parts that work in concert to ensure that the car functions p r o p e r l y.

When servicing their cars and trucks, vehicle owners may look to many parts of the engine yet overlook a relatively mundane, albeit important, component: t h e a i r f i l t e r.

All cars come equipped with air filters, which are essential to optimum engine operation.

The engine air filter is the first line of defense against outside air that is being brought in to the car engine to be burned along with fuel to produce combustion. The filter will capture particulate matter that would normally enter a veh i c l e ’s e n g i n e a n d leave sediment. The automotive resource It Still Runs says dirty air can reduce engine efficiency and cause damage over time.

Dirty air can compromise the air/fuel mixture that is involved in combustion. Any debris that enters portals in fuel injection systems can compromise that system. In addition, debris can cause fuel to burn less effic i e n t l y, r e s u l t i n g i n p o o r f u e l e c o n o m y.

There is no simple answer as to how often an engine air filter should be changed.

It largely depends on miles driven and the environment in which the

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5 Reasons to Eat More Tart Cherries

FAMILY FEATURES

I

f you want to add superfoods to your diet in the new year, Montmorency tart cherries may be perfect for you.

Montmorency is the variety of tart cherries grown in America, primarily on small family farms. Compared to sweet cherries that are typically eaten fresh during the summer season, tart cherries are available year-round as dried, frozen, canned, juice and juice concentrate.

Decades of scientific research has shown Montmorency tart cherries are deserving of their superfood reputation. Here are five reasons to enjoy them more often: n n n

n n

Sleep: Tart cherries are one of the few food sources of melatonin and have been the focus of multiple sleep studies.

Exercise recovery: Tart cherry juice has become a popular exercise recovery drink for athletes.

Arthritis and gout: Studies have explored the impact of Montmorency tart cherry juice consumption on gout attacks and arthritis symptoms.

Heart health: Montmorency tart cherry research has examined blood pressure and blood lipids.

Versatility: Although they remain perfect for pie, tart cherries can easily transition from sweet to savory, adding complex flavors to oatmeal, smoothies, salads, granola bars, trail mix and grain bowls.

Look for dried U.S.-grown tart cherries at the store and online for enjoyment at the start of your day and at night in recipes like Tart Cherry Overnight Oats and Tart Cherry Bedtime Bites.

Find more recipes and scientific research at ChooseCherries.com.

Tart Cherry Bedtime Bites

Tart Cherry Overnight Oats

Recipe courtesy of the Cherry Industry Administrative Board Servings: 2 1 cup dried tart cherries, plus additional for topping (optional) 1 cup old-fashioned oats 1 cup almond milk 1/2 cup slivered almonds, plus additional for topping (optional) 2 tablespoons tart cherry concentrate 2 tablespoons chia seeds 1/2 teaspoon cinnamon honey, for topping (optional) In large jar or container, mix cherries, oats, milk, almonds, cherry concentrate, chia seeds and cinnamon. Cover and refrigerate overnight.

Spoon into bowls and enjoy cold or warmed up. Drizzle with honey or sprinkle with extra dried tart cherries and almonds, if desired.

Tart Cherry Overnight Oats

Tart Cherry Bedtime Bites

Recipe courtesy of the Cherry Industry Administrative Board Yield: 12 bites 6 medjool dates, pitted 1/2 cup dried tart cherries 1/2 cup finely shredded coconut flakes 3/4 cup unsalted cashews 1 teaspoon almond extract 1 pinch fine sea salt In food processor, process dates until broken into peasized bits. Add dried tart cherries, coconut flakes, cashews, almond extract and sea salt; process until combined. Form into 12 balls and chill 2 hours.

A Dark, Colorful Clue The deep red color is your clue to the science-based benefits of Montmorency tart cherries. The vibrant hue is due to the concentration of anthocyanins, a type of polyphenol in the flavonoids family that has been widely studied.

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