Kansas Angus News - July/August 2011 by LivestockDirect

Not in Kansas Any More Summer Fun Jr. Angus Style Carcass Data Project sets 71% CAB Pace

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US 3686/1 F-30510615 USA067796IN v

ÂŽ Estrumate (cloprostenol sodium) Prostaglandin Analogue for Cattle Equivalent to 250 mcg cloprostenol/mL EstrumateÂŽ (cloprostenol sodium) is a synthetic prostaglandin analogue structurally related to prostaglandin F2 Îą (pGF2 Îą). Each mL of the colorless aqueous solution contains 263 mcg of cloprostenol sodium (equivalent to 250 mcg of cloprostenol) in a sodium citrate, anhydrous citric acid and sodium chloride buffer containing 0.1% w/v chlorocresol BP as a bactericide. pH is adjusted, as necessary, with sodium hydroxide or citric acid.

ACTION: Estrumate causes functional and morphological regression of the corpus luteum (luteolysis) in cattle. In normal, nonpregnant cycling animals, this effect on the life span of the corpus luteum usually results in estrus 2 to 5 days after treatment. In animals with prolonged luteal function (pyometra, mummified fetus, and luteal cysts), the induced luteolysis usually results in resolution of the condition and return to cyclicity. Pregnant animals may abort depending on the stage of gestation.

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INDICATIONS: For intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of Estrumate can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.

REQUIREMENTS FOR CONTROLLED BREEDING PROGRAMS: A variety of programs can be designed to best meet the needs of individual management systems. A controlled breeding program should be selected which is appropriate for the existing circumstances and management practices. Before a controlled breeding program is planned, the producerâ&#x20AC;&#x2122;s objectives must be examined and he must be made aware of the projected results and limitations. The producer and his consulting veterinarian should review the operationâ&#x20AC;&#x2122;s breeding history, herd health, and nutritional status and agree that a controlled breeding program is practical in the producerâ&#x20AC;&#x2122;s specific situation. For any successful controlled breeding program: t DPXT BOE IFJGFST NVTU CF OPSNBM OPOQSFHOBOU BOE DZDMJOH SFDUBM QBMQBUJPO TIPVME be performed); t DBUUMF NVTU CF JO B ĂśU BOE UISJGUZ CSFFEJOH DPOEJUJPO BOE PO BO BEFRVBUF PS JODSFBTJOH QMBOF of nutrition; t QSPQFS QSPHSBN QMBOOJOH BOE SFDPSE LFFQJOH BSF FTTFOUJBM t JG BSUJĂśDJBM JOTFNJOBUJPO JT VTFE JU NVTU CF QFSGPSNFE CZ DPNQFUFOU JOTFNJOBUPST VTJOH high-quality semen. It is important to understand that Estrumate is effective only in animals with a mature corpus luteum (ovulation must have occurred at least 5 days prior to treatment). This must be considered when breeding is intended following a single Estrumate injection.

SAFETY AND TOXICITY: At 50 and 100 times the recommended dose, mild side effects may be detected in some cattle. These JODMVEF JODSFBTFE VOFBTJOFTT TMJHIU GSPUIJOH BOE NJML MFU EPXO

CONTRAINDICATIONS: Estrumate should not be administered to a pregnant animal whose calf is not to be aborted.

PRECAUTIONS:

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There is no effect on fertility following the single or double dosage regimen when breeding occurs at induced estrus or at 72 and 96 hours posttreatment. Conception rates may be lower than expected in those fixed time breeding programs which omit the second insemination (ie, the insemination at or near 96 hours). This is especially true if a fixed time insemination is used following a single Estrumate injection. As with all parenteral products, careful aseptic techniques should be employed to decrease the possibility of postinjection bacterial infection. Antibiotic therapy should be employed at the first sign of infection.

DOSAGE AND ADMINISTRATION: Two mL of Estrumate (500 mcg of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for all indications in both beef and dairy cattle. Do not puncture stopper more than 10 times.

WARNINGS For veterinary use only. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, XPNFO NBZ CF VOBXBSF PG UIFJS QSFHOBODJFT &TUSVNBUF JT SFBEJMZ BCTPSCFE UISPVHI UIF TLJO BOE NBZ DBVTF BCPSUJPO BOE PS CSPODIJPTQBTNT EJSFDU DPOUBDU XJUI UIF TLJO TIPVME UIFSFGPSF CF BWPJEFE "DDJEFOUBM TQJMMBHF PO UIF TLJO TIPVME CF XBTIFE PĂ˛ JNNFEJBUFMZ XJUI TPBQ BOE XBUFS

STORAGE CONDITIONS: 1. Protect from light. 2. Store in container. 3. Store at controlled room temperature 59Â°-86Â° F. (15Â°-30Â° c).

HOW SUPPLIED: 20mL and 100mL multidose vials

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

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US 3686/1 B-30510615 USA067796IN v

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The luteolytic action of Estrumate can be utilized to manipulate the estrous cycle to better ďŹ t certain management practices, terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.

Cloprostenol sodium, the active ingredient in Estrumate, is the only prostaglandin approved for controlled breeding in lactating dairy cows. Ask your veterinarian about Estrumate today. At 50 and 100 times the recommended dose, mild side effects may be detected in some cattle; these include increased uneasiness, slight frothing, and milk let-down. For complete information on use, withdrawal period, contraindication, adverse reactions, refer to product package insert on adjacent page.

.PSSJT "WFOVF t 4VNNJU /+ t NFSDL BOJNBM IFBMUI VTB DPN t t #7 &45 MERCK is a trademark of Merck Sharp & Dohme Corp. Merck Sharp & Dohme Corp., Intervet International B.V., and Intervet Inc. are subsidiaries of Merck & Co., Inc., Whitehouse Station, NJ, USA. Copyright 2011 Intervet Inc., a subsidiary of Merck & Co., Inc. All rights reserved

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