Clinical Anti-Aging Study with Lubex anti-age® day and Lubex anti-age® night Single-centre clinical study over three months in women between 45 and 60 years of age with moderately photoaged facial and neckline skin. Dermatological Clinic, Hôpital Saint Jacques, Besançon (Prof. Philippe Humbert, MD) 2008 Application in the morning:
Lubex anti-age cleansing milk (for cleansing) Lubex anti-age day
Application in the evening:
Lubex anti-age cleansing milk (for cleansing) Lubex anti-age night
– physiological measurements of the skin with reviscometer, corneometer, echography, visioscan – photographic documentation and evaluation by dermatologists in a double-blind procedure – auto-evaluation
1. PHYSIOLOGICAL MEASUREMENTS OF THE SKIN a) Global anti-aging index (reviscometer, corneometer, echography, visioscan) Neckline
average standard error standard deviation
Total score
Total score
Face
n = 30 Start
Conclusion:
Start
after 3 months
after 3 months
After 3 months of treatment with Lubex anti-age day and Lubex anti-age night the anti-aging global index in the face and the neckline has significantly improved (p <0.001).
b) Skin tightening (reviscometer)
average standard deviation
n = 30
Start
Conclusion:
6W
12 W
Reviscometer units
Neckline
Reviscometer units
Face
Start
6W
12 W
After 3 months of treatment with Lubex anti-age day and Lubex anti-age night the skin in the face (p 0.05) and in the neckline (p 0.006) has significantly become tighter.
c) Hydration (corneometer)
n = 30 Start
Conclusion:
6W
12 W
Corneometer units
Neckline
Corneometer units
Face
Start
6W
12 W
Although the skin in the face and the neckline was well hydrated at the beginning of the study (approx. 51 corneometer units) a significant increase in hydration in the face (p <0.01) and the neckline (p <0.01) was observed after 3 months.
2. SKIN TOLERANCE The skin tolerance of Lubex anti-age day, Lubex anti-age night and Lubex anti-age cleansing milk was excellent in all study participants. There were no hypersensitivity reactions.
3. PHOTOGRAPHIC DOCUMENTATION
Conclusion:
After 3 months of treatment the severity of both the nasolabial wrinkle depth as well as around the eyes has been greatly reduced. This was assessed by dermatologists in a objectified double-blind procedure.
Beginning of the study
After 3 months
4. AUTO-EVALUATION Anti-aging effect of Lubex anti-age day + Lubex anti-age night
Face
3%
7% very good good mediocre bad
40% 53%
Neckline
40% 57%
n = 30
Conclusion: The anti-aging effect in the face was judged as good to very good in 93% of the cases and the anti-aging effect in the neckline in 97% of cases.
Skin penetration capacity Lubex anti-age day
Texture
Lubex anti-age night
7%
Lubex anti-age day 10%
3% 37%
Lubex anti-age night
37%
40% 57%
56%
57%
63%
33%
very good good mediocre bad
very pleasant pleasant mediocre bad
n = 30
n = 30
Conclusion: The skin penetration capacity
Conclusion: 90% of the study participants
was observed as good or very good in 93% of the cases for Lubex anti-age day and in 97% of the cases for Lubex anti-age night.
judged the texture of Lubex antiage day to be pleasant or very pleasant. For Lubex anti-age night the study participants estimated this to be even 100%.
Perfume Lubex anti-age day
Satisfaction
Lubex anti-age night
Lubex anti-age day
7%
10%
7% 23%
37% 70% 56% very pleasant pleasant mediocre bad
n = 30
Conclusion: The perfume of Lubex anti-age day and Lubex anti-age night was judged by 93% of the women as pleasant or very pleasant.
Lubex anti-age night 3%
63% 27%
27%
70%
very good good mediocre bad
n = 30
Conclusion: Satisfaction for Lubex anti-age day was in 90% and for Lubex anti-age night in 97% of the cases good or very good.
Skin tightening Neckline
Face
Start
Hydration
after 3 months
Start
after 3 months
Conclusion: Already after 3 months the skin of both the face and the neckline has become visibly tighter.
Start
after 3 months
Start
after 3 months
Skin wrinkles Face
Neckline
after 3 months
Start
Conclusion: The increase in skin moisture in the face as well as in the neckline after 3 months is highly significant.
Skin smoothing Face
Neckline
Face
Start
Start
after 3 months
Conclusion: After 3 months the skin in the face and neckline has become significantly smoother.
Neckline
after 3 months
Start
after 3 months
Conclusion: Skin wrinkles in the face and neckline were reduced significantly after 3 months.
Radiant complexion Neckline
Face
Start
after 3 months
Start
after 3 months
Conclusion: The skin in the face and the neckline has become more radiant after 3 months.
5. OVERALL STUDY CONCLUSION FOR LUBEX ANTI-AGE DAY AND LUBEX ANTI-AGE NIGHT
The physiological measurements of the skin showed a significant improvement of the anti-aging global index, of the tightening and hydration of the skin. After 3 months of treatment the severity of both the nasolabial wrinkle depth as well as around the eyes has been greatly reduced. This was assessed by dermatologists in a double-blind procedure. Lubex anti-age day and Lubex anti-age night proved to be effective anti-aging products: In 93–97% of all cases the anti-aging effect in the face and neckline was judged as good or very good.
After 3 months of treatment the skin in the face and the neckline has become significantly smoother, tighter, better hydrated and more radiant. Skin wrinkles were greatly reduced. 90–97% of all study participants judged Lubex anti-age day und Lubex anti-age night to be good or very good. The skin tolerance was described by all participants as being excellent.
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