CLINICAL REPORT
CLINICAL MANAGEMENT OF EXOCRINE PANCREATIC INSUFFICIENCY IN A GERMAN SHEPHERD DOG V. Dhanesh 1, Usha Narayana pillai 2 ,S.Yogeshpriya 3, 4 5 Roshna Rasheed Kutty and S.Ajith Kumar Department of Clinical Veterinary Medicine, College of Veterinary and Animal Sciences , Mannuthy INTRODUCTION: Exocrine pancreatic insufficiency is the inability to digest food properly due to the lack of digestive enzyme made by the pancreas. animal will show clinical sign if there is greater than 85 percent loss of the pancreatic acinar which has ability to secrete digestive enzyme and it is clinically characterized by loss of weight , pica, coprophagia, poor quality hair coat etc. Consistency of the faces becomes oily, smooth, and soft. Perineal region will be oily stained because of steatorrhea.
J. Ind. Vet. Assoc., Kerala. 10 (1)
CASE HISTOY AND CLINICAL INVESTIGATION A three year old GSD was presented in the university hospital Mannuthy with a history of foul smelling diarrhea of three month duration. The animal was treated with anthelmintics and Sulfa TMP combination (Septran) by local veterinarian. Owner reported that there is considerable weight loss even though the animal was take normal quantity of food. On examination, physiological parameters like temperature((103 0 F) , heart rate (108 beats / min), pulse rate (107/min) and mucous membrane (pale roseate) were found to be normal consistency of the fecal sample was found to be oily and semisolid standard parasitological examination was done and no ova of parasitic important could be detected. But large number fat globules were present in the sample. No change could be detected in Haemogram. Fecal sample was positive for X- ray film test. Based on X1. 3, 4- P.G Scholar, 2. Associate Professor , 5.Professor and Head
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ray film test and history the case was clinically diagnosed as exocrine pancreatic insufficiency.
TREATMENT AND DISCUSSION Treatment was carried out with Tab. Enzar forte, 1 tab twice daily along with this Tab. Flagyl 400 mg, 1 tab twice daily and Tab. Rantac 150 mg, ½ tab twice daily. Advised the owner to review the case after 10 days. Owner reported that animal is showing much improvement in the condition. Consistency of the feces becomes normal without any foul smell. In dog Exocrine pancreatic insufficiency is mainly due to pancreatic acinar atrophy and in cat it is due to destruction of the acinar tissue associated with subclinical or chronic pancreatitis. (Nelson et. al 2003). Pancreatic enzyme had a antibacterial property and in Exocrine pancreatic insufficiency lead to over growth of different type of bacteria in small intestine. Over growth of the bacteria will lead to changes in the small intestine like villous atrophy, alteration in the mucosal enzymatic activity etc. Bacterial count in the small intestine will be more
CLINICAL REPORT
than 10 6 colony forming unit / gram of intestinal content which is much higher than the normal value (Regan, 1977). So to avoid these, oral antibiotics like Metronidazole at dose rate of 7.5-15 mg/kg BW twice daily or Tylosin at a dose rate of 20-30 mg/kg BW / day for 6 week were advocated. Fresh raw pancreas of beef can be advisable for animals which are suffering from exocrine pancreatic insufficiency. Porcine pancreas is not preferable because there is a chance of Aujezk's disease. (Khan et al 2005). Confirmatory test for the exocrine pancreatic insufficiency is estimation of the serum trypsin like immunoreactive (TLI) protein. In normal range for the TLI are 5- 32 micro g / L. If the concentration is less than 2 micro g/ L, it is considered as the animal is suffering from the exocrine pancreatic insufficiency (Westermarck, 2003). In most of the case animal need a lifelong treatment.
REFERRENCE: Khan, C.M 2005: the Merck Veterinary Manual, ninth edn, Merks & Co., INC, Whitehouse station, U.S. 2712pp Nelson, R.W., Couto, C.G. 2003: Small Internal Medicine, Third edn, Mosby, Missouri, U.S. 1362pp Westermarck, E., Wiberg, M. 2003: Exocrine pancreatic insufficiency in dogs, Vet Clin North Am Small Anim Pract. 33: 11651179pp Regan, P.T., Malagelada, J.R., Dimango, E.P., Glanzman S.L., and Vay, L.W. 1977: C o m p a r a t i v e E ff e c t o f A n t a c i d s , Cimetidine and Enteric Coating on the Therapeutic Response to Oral Enzyme In Severe Pancreatic Insufficiency. N Engl J Med. 297: 854-858pp
INDEXING AND ARCHIVING IN CAB ABSTRACTS JOURNAL OF INDIAN VETERINARY ASSOCIATION, KERALA From Subject To Date
: Uma Sabapathy Allen <u.allen@cabi.org> : Indexing and archiving in CAB Abstracts - Journal of Indian Veterinary Association, Kerala : "vijikumaran@yahoo.com" <vijikumaran@yahoo.com> : Tuesday, 28 February, 2012, 21:34
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JIVA Vol. 10
Chief Editor, Journal of Indian Veterinary Association, Kerala (ISSN 0975-5195) I am writing on behalf of CAB International regarding the Journal of Indian Veterinary Association, Kerala. We recently evaluated the journal according to our internal selection criteria of potential yield, scientific value and geographic origin and judged its content to be both novel and important, and deemed to be very relevant to the CAB Abstracts database produced by CABI. We would therefore like to request permission not just to abstract and index the title but also to archive the journal's full-text content in the CABI Full-Text Repository. For the latter we would only require non-exclusive internet publishing rights; copyright remains with the publisher/author, allowing them to publish the material through any internet site/publication. I understand the JIVA is an open access publication. By including the JIVA and as many publications as possible in the full-text repository, we hope to ensure that they are preserved and easily located by researchers and professionals throughout the world, both now and in the future. This would also be a valuable way of promoting the publications amongst the global users of CAB Abstracts. A list of documents currently available in the repository can be viewed at http://www.cabi.org/fulltext Please let me know if you require further information to support this request.
Issue 1 April 2012
Dr. K.Vijaya Kumar
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