1.
Top 10 Changes in 2008 Guidelines ICD recommendations collapsed into one list given overlap
2.
MADIT II indication Class I, changed from Class IIa.
3.
CRT indications clarified.
4.
CRT therapy is to be prescribed only when patients have been treated with optimal medical therapy.
5.
Primary prevention ICD indication made for nonischemic cardiomyopathy forthrightly addressed using SCD-HeFT for support.
6.
Conservative use of EF for primary prevention ICD indication, lower than ventricular arrhythmia guidelines, but based on entry criteria for trials on which recommendations are based.
7.
New section addressing device management at end of life.
8.
Risk assessment needed, with inclusion of the patient in the discussion.
9.
Brugada syndrome indication now Class IIa, changed from Class IIb.
ICD recommendations collapsed into one list given overlap between primary and secondary indications.
10. Indications for ICDs revised to recognize newly recognized diseases such as catecholaminergic polymorphic VT .
Most Significant Trials Used in 2008 Guidelines
CARE-HF
COMPANION
MADIT II
SCD-HeFT