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ear friends first of all I would like to say you all deeply
thanks for being here either as a our readers or supporter or our audience and how we can forget your great support for continuous launching of Microbioz India magazine. Dear friends Microbioz India going to launch anniversary edition of magazine featured with most interesting cover story for our audience entitled: “10 interesting facts of Zika� written and covered by Microbioz India editorial office. The cover story of this month will boost awareness and more as suggest few interesting on Zika virus updates and disease transmission. Dear friends apart from cover story magazine have an interesting featured article named 5 Bacterial mysteries uncovered: 2016 one of interesting uncovered over few bacterial mystery. Dear friends Microbioz India magazine from since last one year dedicated to build huge academic audiences and as we know our team members ,authors always tried to win heart of each audience for expel out quality cover story and maintain magazine contents in each edition and we ensure you all for doing same in near future. Collect lot of open scholarship position for pursuing higher education in the field of Microbiology, Biotechnology and Medical Sciences from reputed Universities of across the globe. In last phase of this magazine how we can forget to announce the names of winners of our March 2016 edition of crossword, Dear friends we request you to all for earlier submission of your answers and other feedbacks about magazine editions.
Thanks
Jeetendra Kumaar
08 Cover Story: 10 interesting facts on ZIKA 15 5 Bacterial mysteries Uncovered: 2016 18
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Gut microbiota transfer affects brain dysfunction and nerve fiber insulation
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Researcher finds new mechanism responsible for cancer approach
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Bacterial feeding over fish gills, 20 type of new symbiosis: Recent study Tax over sugary drinks would 21 reduce annual health expenditure by $29 million as well as reduce obesity cases 25
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High fatty diet may trigger day time sleeping New molecular structure of antibiotic for fighting with all types of bacterial strain
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28 Great initiative takes by Tata trust 29 Microbioz positions 37
India:
Scholarship
Microbioz India Crossword: April 2016
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Zika is virus of family Flaviviridae and known to one of well known infectious disease spread through bite of day time mosquito named Aedes aegypti. As history suggest name Zika came from forest Uganda. The infection known to be Zika fever similar to Dengue fever. In 2015 to Mexico, Central America, the Caribbean, and South America, where the Zika outbreak has reached pandemic levels. Zika is most sensitive to pregnant women and infect new born baby
Characterized with brain problem named Microcephaly. There are number of effective vaccine available for treatment of other Virus in Flaviviridae family. WHO experts have suggested that the priority should be to develop inactivated vaccines and other non-live vaccines, which are safe to use in pregnant women and those of childbearing age. Here in Microbioz India April 2016 edition of magazine we share one of fantastic cover story explains 10 interesting facts about Zika virus.
Gut microbiota transfer affects brain dysfunction and nerve fiber insulation: Recent study Multiple sclerosis is type of an autoimmune disease led by damage in myelin, the insulating sheath around the axons of nerve cells that allows for faster electrical impulse conduction. Myelination is critical for everyday brain function and damaged myelin results in number of brain dysfunction which includes altered synaptic transmission and clinical symptoms. The researcher from The Mount Sinai Hospital / Mount Sinai School of Medicine recently suggest targeting intestinal bacteria, or their metabolites, could be one way to treat debilitating psychiatric disorders and demyelinating diseases, like multiple sclerosis. The concern research recently appears in medical journal eLife.
We are hopeful these metabolites can be targeted for potential future therapies."In an effort to define the mechanism of gut-brain communication, researchers identified bacterial communities associated with increased levels of cresol, a substance that has the ability to pass the blood-brain barrier. This current study led by Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomics, and Neurology, and Chief of the Center of Excellence for Myelin Repair, and post-doctoral fellow Mar Gacias, PhD, identifies bacteria-derived gut metabolites that can affect myelin content in the brains of mice and induce depression-like symptoms. Note: The above story is for information purposes for more information go through original story source.
According to researcher, "Our findings will help in the understanding of microbiota in modulating multiple sclerosis," says Dr. Casaccia. "The study provides a proof of principle that gut metabolites have the ability to affect myelin content irrespective of the genetic makeup of mice.
Story source: The Mount Sinai Hospital / Mount Sinai School of Medicine Journal References: Mar Gacias, Sevasti Gaspari, Patricia Mae-Santos, Sabrina Tamburini, Monica Andrade, Fan Zang, Nan Shen, Vladimir Tolstikov, Michael A Kiebish, Jeffrey L Dupree, Venetia Zachariou, Jose C Clemente, Patrizia Casaccia. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. eLife, 2016; 5 DOI: 10.7554/eLife.13442
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Researcher finds new mechanism responsible for cancer approach: New hope for pancreatic cancer treatment As we all know pancreatic cancer is one of most serious cancer type and few report suggest pancreatic cancer is one leading cancer cause death by 2020.Researcher from Thomas Jefferson University recently finds new mechanism that could be responsible for the cancer's resistance to at least one targeted approach. If the results hold true in animal models and eventually clinical trials, the approach could help researchers develop more effective combination therapies and breathe new life into forgotten and failed cancer drugs. The study recently appeared in journal Molecular Cancer Research, Dr. Brody and colleagues showed that a protein called HuR (Hu antigen R) is a hub for cancer cell survival and drug resistance, especially when pancreatic cancer cells are treated with TRAIL. According to researcher, "We've teased out one mechanism behind pancreatic cancer cells' resistance to certain drugs," says Jonathan Brody, Ph.D., a researcher at the Sidney Kimmel Cancer Center at Thomas Jefferson University and
Director of Surgical Research at Thomas Jefferson University. "Knocking out this resistance mechanism could make pancreatic cancer vulnerable to therapies that had great promise in the past. While there's more work to be done to confirm the results in pre-clinical models and then humans, we are encouraged by these preliminary results." Note: The above story is for information purposes for more information go through original story source. Story source: Thomas Jefferson University Journal References: C. Romeo, M. C. Weber, M. Zarei, D. DeCicco, S. N. Chand, A. D. Lobo, J. M. Winter, J. A. Sawicki, J. N. Sachs, N. MeisnerKober, C. J. Yeo, R. Vadigepalli, M. L. Tykocinski, J. R. Brody. HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expressions in Pancreatic Cancer Cells. Molecular Cancer Research, 2016; DOI: 10.1158/1541-7786.MCR-150448
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Now intake of antibodies and other drugs two to three times in a day is replaced by engineered pills Researcher from Massachusetts Institute of Technology designed engineered pills that releases drug for long term if once swallowed while attaching with inner lining of gastrointestinal tract. Pills engineered in such a way that one side attach with tissue and other side repels foods and liquids. The concern research appears in April 6 issue of the journal Advanced Healthcare Materials. According to senior author of research, "This could be adapted to many drugs. Any drug that is dosed frequently could be amenable to this kind of system," says Giovanni Traverso, a research affiliate at MIT's Koch Institute for Integrative Cancer Research, a gastroenterologist at Brigham and Women's Hospital. The research one of senior author is Robert Langer, the David H. Koch Institute Professor and a member of the Koch Institute and Young-Ah Lucy Lee is leading author of paper. Make note that since last few years Langer laboratory developed number of drugs adhere with intestinal lining for long term drug release, they did this brilliant job by using compound named, “Mucoadhesives� which attaches drug with inner linings of GI tract.
As a sample testing researcher uses pigs intestinal tissue to test the adherence of pills they used three type of drug while experimenting named, dual-sided Mucoadhesives tablet, a dual-sided omniphobic tablet, and the Janus version, with one Mucoadhesives side and one omniphobic side. At the results find dual-sided Mucoadhesives tablets only adheres 7 seconds of time while dual-sided omniphobic tablet adheres less than one seconds in turns Janus version adheres up to 10 minutes."There are certain medications that are known to get stuck, particularly in the esophagus. It causes this massive amount of inflammation because it gets stuck and it causes irritation," Traverso says. Note: The above story is for information purposes for more information go through original story source. Story source: Massachusetts Institute of Technology Journal References: Young-Ah Lucy Lee, Shiyi Zhang, Jiaqi Lin, Robert Langer and Giovanni Traverso. A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention. Advanced Healthcare Materials, April 2016 DOI: 10.1002/adhm.201501036
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