Microbioz India CPHI edition of the magazine

30

38

42

16

44

20 Cover Story

16

The cover story of the month titled: Analysis of Food Ingredients by an Analytical Technique – HPLC authored bySrushti Sanghavi- Shah Nanghavi Chromatography Solutions the story features the food we consume today is more versatile and processed than ever before. Therefore, the quality of food is a major topic of concern for human health. To ensure the nutritional quality and safety of food many countries have implemented regulations that specify tolerable levels for individual chemical additives and contaminants in food product and list those ingredients with respect to their content.

Featured article

26

Added to this, the current edition has a special featured article titledLiquid Silicone Rubber (LSR) based products and its applications by Liquid Silicone Rubber (LSR)authored by Shrikant Dethe(Business Development)Ami Polymer Pvt. Ltd.

Product Launches

38

The edition also covers recent Pharma news articles and product launches collected from worldwide sources to update the readers with the current trends in the industry

Eppendorf presents first internally developed CO2 incubator

30

“Today´s cell culture requires more than technical solutions for optimized growth conditions and efficient contamination prevention.” says Eppendorf´s Business Manager for cell culture products Dr.Patrik Ferreira. “For several years, customers involved in Eppendorf´s development process have reported an increasing demand for devices that provide flexibility, supportwith increasing documentation demands and use natural resources sustainably.

KayPee Udyog’s TEMPSTAR - A Brand to Trust for Every Product Requirement

32

KayPee Udyog, an Ambala, India based organization knowing as a trusted name in the market of high-profile scientific instrument, manufacturing and supplying scientific instruments for the last 56 years with remarkable product quality and services. It came up with a brand name as “TEMPSTAR”, dealing in wide range of laboratory instruments.

Microbioz India, December 2018

12

ear friends and readers, I hope you would have enjoyed reading our previous issue. Once again, I am delighted to bring for you the annual edition of your favourite magazine Microbioz India. It is a “CPHI and P-mec India special edition” supported by the cover story titled ‘Analysis of Food Ingredients by an Analytical Technique – HPLC by Srushti Sanghavi- Shah Nanghavi Chromatography Solutions.

The story features the food we consume today is more versatile and processed than ever before. Therefore, the quality of food is a major topic of concern for human health. To ensure the nutritional quality and safety of food many countries have implemented regulations that specify tolerable levels for individual chemical additives and contaminants in food product and list those ingredients with respect to their content.

The current edition has also brought for you a featured article on “Liquid Silicone Rubber (LSR) based products and its applications by Liquid Silicone Rubber (LSR)” authored by Shrikant Dethe(Business Development)Ami Polymer Pvt. Ltd. We have the latest market research news and insightful product launches inside, collected from worldwide sources to keep you updated with what is going on in the industry.

Dear friends and readers, I hope you find some value in the magazine. Also, I would like to thanks you for being together in this beautiful journey so far. We would love to have your valuable feedback and suggestions as they help us to come up with better content each time. For any further valuable addition, please write to us at editor@microbiozindia.com.

Cover Story

Analysis of Food Ingredients by an Analytical Technique – HPLC he food we consume today is more versatile and processed than ever before. Therefore, the quality of food is a major topic of concern for human health. To ensure the nutritional quality and safety of food many countries have implemented regulations that specify tolerable levels for individual chemical additives and contaminants in food product and list those ingredients with respect to their content.

T

Our food contains quite a lot of extra ingredients such as colourants which help to Increase acceptability and appeal of the food, food preservatives and antioxidants to increase the life of the food product, natural and artificial sweatners and flavours – to improve the taste of food, natural and synthetic vitamins to increase the nutritive value of food. All these components are required in certain small quantities and can causes long term toxicity if consumed above the

set limits; which causes harmful effects. Therefore, there are regulatory bodiesthat look after this to ensure that these additives do not go beyond the prescribed levels which maybe toxic in higher quantities. Analytical methods have been developed for the qualitative and quantitative analysis of these food products, ingredients to ensure safety.

One such analytical technique widely used is the High Performance Liquid Chromatography (HPLC) is a chromatographic technique, widely used to separate a mixture of compounds for identifying, quantifying and purifying the individual components of the mixture. It is used in structure elucidation and quantitative determination of impurities and degradation products in bulk materials.Major applications cover mainly research and quality control studies in new drug development, pharmaceutical manufacturing, and even in studying stability of

Microbioz India, December 2018

16

Cover Story critical food ingredients. And one of its new areas of application is nutrition labelling.

As an example, during industrial poultry production such a chicken, to prevent the chicken to catch any diseases, the farmers feed them with antibiotics such as enoxacin. The food and drug authority has set a maximum limit of antibiotics that can be present in chicken meat and ensures that producers comply with those limits to ensure public safety.

This particular test has been suggested to be done on a HPLC machine. Attached is a example of the same. The manufacturer of that food product can check their product quality. These have to be standardised tests which the governing agencies can also check in their laboratories or from any certified public testing laboratory.

In the analysis of food samples, HPLC is widely used for the separation and detection of

contaminants and additives. It is a non-destructive detection technique, which enables the collection of fractions for further analysis.HPLC brings separation and identification at ambient temperature. Therefore Food and Drug Administration (FDA) has approved and recommended HPLC for the analysis of highly polar, non-volatile and thermally labile compounds. Nanghavi is in the business of manufacturing HPLC columns.

To know more about HPLC testing on food ingredients pertaining to ingredients identification and safety levels, or further enquiries and technical details contact: info@nanghavi.com Author: Srushti Sanghavi- Shah Nanghavi Chromatography Solutions

Microbioz India, December 2018

18

Pre Event

The 3rd edition of the India Pharma Week gears up for a grand debut in Delhi-NCR A week full of avant-garde events alongside the 12th edition of CPhI & P-MEC India to take place at the India Expo Mart, Greater Noida    

South Asia’s largest Pharma event CPhI and P-MEC India to be held for the first time at the India Expo Mart - Greater Noida, with all its attendant facilities from 12-14 December Over 1600 exhibitors from above 42 countries More than 7 eclectic engagements will form a part of the IPW

Delhi-NCR, November 26th , 2018: UBM India, India's leading B2B exhibition organizer, is all set to bring in the third edition of the widely appreciated India Pharma Week, a week-long celebration packed with avant-garde events from 9th – 14th December, alongside the 12th edition of its flagship expo CPhI and P-MEC India. South Asia’s largest Pharma event will be held for the first time at the world class venue of the India Expo Centre, Greater Noida, with all its attendant facilities, moving away from the commercial

capital of Mumbai. This will enable all the key stakeholders and professionals of the pharma industry the convenience to congregate at the marquee show, network and celebrate the industry under one giant umbrella for an entire week.

Commemorating the 12 years of the CPhI & PMEC India expo, the India Pharma Week will organize more than 7 events and activities pertaining to the streams of business, knowledge, leadership, innovation, recognition and networking in the field of Pharma. As a tribute to Microbioz India, December 2018

20

Pre Event the city in which it was born and reared, the India Pharma Week will tee off with a Pharma Leaders Golf in Mumbai. The scene of action will then shift to Greater Noida where the IPW will be packed with a series of dynamic engagements such as Pharma Connect Congress, Women in Pharma, India Pharma Awards, Networking Evening, the CPhI & P-MEC India Exhibition and a closeddoor CEO Roundtable, among others. The shift to the Delhi-NCR region will help the magnum opus further develop and nurture a complete

the medley of captivating events, key discussion areas will include ‘Growth of Indian Pharmaceutical industry: Vision 2020’, ‘Transforming the Pharma industry architecture through collaborations’, and ‘Strategies to strengthen regulatory policies in India’ among many others, for the community to ruminate and act upon,”.

“With an estimated spend of over US$ 200 billion on medical infrastructure in the next decade; India is keen to make drugs affordable as well as available in all corners of the country. What is also equally required to make India a global leader in end to end pharma manufacturing, as

pharma ecosystem in the sectoral pockets of the North, also keeping in mind its power corridors.

Originally Incepted in 2006, the CPhI & P-MEC India exhibition has grown remarkably larger over the years with exhibitors and visitors from Indian and overseas engaging over significant levels of business. It has been approved and comprehensively assisted in its endeavors by governing bodies such as Pharmexcil, CIPI and IDMA. This year's edition will witness participation from more than 1,600 exhibitors from over 42 countries. Special pavilions by Pharmexcil, CCCMHPI & CCPIT will form an intrinsic part of the expo.

The India Pharma Week with its mélange of events was launched in 2016 to celebrate CPhI & P-MEC’s ten years of existence. Onsite, several innovative engagement platforms such as Supplier Finder, CPhI TV, Live Streaming, Mobile Apps, Tech Walls, Matchmaking - Live Pharma Connect, Exhibitor Showcase, and Innovation Gallery among others are sure to make the visitor experience an engaging and memorable one.

encapsulated by The ‘Pharma Vision 2020' is a heightened appreciation and awareness about compliance requirements and investment in R&D. These factors seem to have been comprehended by the pharma community with around 9 per cent of sales by organisations being re-invested in R&D and 46 mergers having been affected in 2017-18.

These will, no doubt, go a long way in leading the country on to further innovation, discovery and patents to maintain its stronghold over the sector,” he further added

Speaking on IPW 2018, Mr. Yogesh Mudras, Managing Director, UBM India said, “I am delighted to announce the third edition of the weeklong India Pharma Week -- an unrivalled offering to the world of exhibitions -along with the CPhI & P-MEC India, UBM’s flagship engagement platform, and the world’s leading Pharmaceutical networking event in the Delhi-NCR region at a world class venue that an elite congress such as the one at IPW richly deserve. The shift to the region, in close geographical proximity to the Centre, policy makers, consulates and government bodies will enhance our community building efforts. Apart from the business, and

Events under IPW: Pharma Leaders Golf: Scheduled for 9th December, this off-the-beaten track event will have leaders from top pharmaceutical companies getting together over a game of Golf. Around 25 chiefs will tee off under the balmy winter sun for a fun and networking day. Innumerable business opportunities and contacts will be built over a friendly round of golf – a perfect way to warm-up a few days before the grand CPhI & P-MEC India exhibition begins.

CPhI & P-MEC: As the pharma industry is increasingly looking towards India for high quality, low cost pharma solutions, CPhI & P-MEC India is the perfect event for companies to pick up on the latest trends and innovations the market has to offer. The event is scheduled for 12th – 14th December, and enables attendees to meet the movers and shakers in India’s pharma machinery, technology and ingredients industry for a competitive advantage that will help grow your business.

India Pharma Awards and Networking Night: The grand stage of India Pharma Awards is back in its

Microbioz India, December 2018

22

Pre Event 6th year to celebrate the advances & achievements of the Indian Pharmaceutical Industry on 12th December 2018. A part of the Recognition & will bring together industry Networking stream, India Pharma Awards 2018 champions, stalwarts & visionaries from around the world. The journey for the awards has proved to be interesting with increased number of nominations, partnerships and audience footfalls year-on-year. India Pharma Awards is not only a platform for the pharma companies in the country but also a platform that honours individual achievements within those companies, hence, serving as the best platform for the universe of pharma. India Pharma Awards, one of the most transparent & process driven awards are conducted professionally as well as methodically to draw out the best in the industry, and it stands as an opportunity to position your brand with the best in the Pharmaceutical space.

This is done with a neutral Jury Panel representing various segments of the industry.

Pharma Connect Congress: India’s pharma market is set to outperform the global industry. To boost the sector further, with the theme of ‘Ideate.

Innovate. Integrate’, the Pharma Connect Congress will work cohesively towards achieving the Pharma Vision of making India the next major hub of end-to-end drug discovery. The event is scheduled for 12th December 2018 and the topics of discussion will include ‘Transforming the Pharma Industry Architect Through Collaborations’, ‘Strategies to Strengthen Regulatory Policies in India’, ‘Role of Digitalization in Transforming the Pharmaceutical Sector’ and ‘Leveraging Latest Innovations in Technology’ amongst others.

CEO Roundtable: For the last 2 years, this has been known as the one of the marquee events of IPW. In the 3rd edition, which is scheduled for 12th December, the exclusive, closed door CEO Roundtable has been eminently successful as a strategic gathering of CEOs of leading pharma companies who will deep dive into thoughtprovoking discussions.

Women Leaders in Pharma: This summit celebrates the does and the doing – an initiative aimed at acknowledging and celebrating the significant and continued contribution of women to the pharma industry. Scheduled for 13th December, it will bring women luminaries from

around the world on a common platform to share their success stories, experiences and knowledge.

Revolving on 3 core pillars; leadership, entrepreneurship and gender diversity, the 3rd edition of Women in Pharma will feature scintillating discussions like ‘Can Women have it all? Balancing Life and Work’ and ‘Strategies to Make our Organizations More Diverse and Adopting Inclusive Leadership’ amongst many more.

About the CPhI & P-MEC expo: Originating from CPhI Worldwide – CPhI India has become South Asia’s leading Pharma meeting place covering every step of the supply chain from drug discovery to finished dosage, encompassing CROs, CMOs and manufacturers of API, Generics, Excipients and Drug formulation, Fine chemicals, Biosimilars, Finished Formulations, Lab chemicals and Biotechnology.

P-MEC, on the other hand, includes manufacturers of Pharma Machinery and Equipment, Analytical Equipment, Automation & Robotics, Packaging Equipment & Supplies, Plant / Facility Equipment, Automation & Controls, Processing Equipment, RFID, Tableting / Capsule fillers, Clean room equipment, Filling equipment and Laboratory products.

About India Pharma Week: The 3rd edition of India Pharma Week will be organised by UBM, which in October 2018 combined with Informa PLC to become a leading B2B information services group and the largest B2B Events organiser in the world. Please visit www.cphi.com/india/pharma-week for more information on India Pharma Week and www.ubm.com/global-reach/ubm-asia for our presence in Asia.

About UBM Asia: UBM Asia recently became part of Informa PLC, a leading B2B information services group and the largest B2B Events organiser in the world. Please visit www.ubm.com/asia for more information about our presence in Asia.

For any media queries please contact: UBM India Roshni Mitra / roshni.mitra@ubm.com Mili Lalwani/ mili.lalwani@ubm.com +91-22-61727000

Microbioz India, December 2018

24

Featured Article

Liquid Silicone Rubber (LSR) based products and its applications Introduction Liquid Silicone Rubber (LSR) has come into existence since the late 1970s. Initially it was developed as two part systems cured by hydrosilylation reaction. These two part system includes: Part A= vinyl-end capped PolyDiMethylSilioxane (PDMS), platinum catalyst, inhibitor and Part B= PolyMethylHydroSiloxane (PMHS).

These two parts are kept separately before curing to avoid any partial crosslinking during storage. This reaction is exothermic in nature. Finished LSR products are naturally transparent butmay be easily colored by use of nonhazardous pigments. Liquid silicone rubbers do not contain any plasticizers, stabilizers, or promoters.

Their exceptional flex characteristics are due to their unique chemistry.

Img 1: Reaction involved in the making of Liquid Silicone Rubber

Advantages of LSR over other solid silicone rubbers?

Solid silicone rubbersare processed in the same way as common organic rubbers.Liquid silicone rubbers (LSR) have the same structure as solid silicone rubbers but the chain length of the polydimethylsiloxane used for LSR is lower by a factor of about 6. Other major factors which distinguishes LSR from other solid silicone rubbers includes the following: Molding cycle time:Major factor where LSR leads is because of faster cycles involved in product generation Complex geometries: Because of flow property in LSR, the liquid fits in the complex shape of mold Contamination:Due to the closed process involved in the production of LSR products, it results in low contamination Labor: Due to presence of automation and less stages

involved, LSR injection equipment requires minimal labor Uniform material preparation:LSRs require no materialpreparation which removes the uncertainty of uniform mixing Cavity surface finish:LSR duplicates exactly the surface of the cavity using molds made from polished steel or plated chrome

High Temperature Vulcanization (HTV) silicone rubbers come in two different physical states: liquid and solid.

These are respectively Liquid Silicone Rubbers (LSR) and High Cure Rubbers (HCR) -aka solid silicone rubbers.

Microbioz India, December 2018

26

Featured Article Scrap generation: LSR generates zero scrap as liquid is uniformly filled in the mold which results to brilliant finishing Biocompatibility: Under extensive testing, LSR has demonstrated superior compatibility with human tissue and body fluids.

Transparency: LSR possesses a natural transparency which is an added benefit.

Icon Images for above mentioned bold points:

Manufacturing process  Two Components (A and B) are supplied at a regular ratio by dosing pumps.  Part A and B are then mixed together in a mixing block and a static mixer.  If any color paste is necessary, it is then mixedwith thecompound  The platens and pistons which align and close the mold have settings for temperature, pressure, injection rate and cycle time  Combination of heat and pressure is applied to the LSRwhichcures the material until it solidifies.  Upon completion of the cycle, the mold opens and the part and flashing can be removed automatically or by a worker  Cured product comes of the mold and the process is repe

Medical: needle less injection sites, menstrual cups, infusion pumps and tips, caps and stoppers, membrane pumps, ultrasonic blades, metal over molding, skin contact products, implantable products

Industrial: T/C gaskets, O-rings, check valves, outdoor applications

Automotive: spark plug boots, bellows, T/C gaskets, O-rings, interior complex components

Applications Food and household appliances= Baby products (nipple), Cake molds, Kitchen wares

Electronics =Keypads, Parts for electronic devices

Microbioz India, December 2018

28

Featured Article

By: Shrikant Dethe (Business Development) Ami Polymer Pvt. Ltd. Mob: +91 9152032304 Email ID; shrikant@amipolymer.com

Lenses LED lighting

Market News

Eppendorf presents first internally developedCO2 incubator Chennai, December04, 2018 – “Today´s cell culture requires more than technical solutions for optimizedgrowth conditions and efficient contamination prevention.” says Eppendorf´s Business Manager for cell culture products Dr.Patrik Ferreira. “For severalyears, customers involved in Eppendorf´s development process havereported an increasing demand for devices that provide flexibility, supportwith increasing documentation demands and use natural resourcessustainably. We also noticed more questions regarding a future ‘connected lab’ environment during customer contacts in the last two years.”

After acquisition of New Brunswick Scientific including its well-knownGalaxy® CO2 incubators in 2007 and decades of market experience,Eppendorf now presents its own inhouse development to fulfill the abovedemands.

Produced in Hamburg, Germany, the new CellXpert® CO2 incubatorfamily adopted several established features like a fanless design and a deepdrawnchamber. In addition, it incorporates several innovations like multipleintegrated temperature sensors, a smart gas control and a

magnetic doorclosing concept for enhanced ergonomics. The CellXpert also includes Eppendorf’s VisioNize® system for remote monitoring.

Information about Eppendorf´s new CellXpert CO2 incubator is available atwww.eppendorf.com/cellxpert.

About Eppendorf: Eppendorf is a leading life science company that develops and sells instruments, consumables, and services for liquid handling, sample handling, and cell handling in laboratories worldwide. Its product range includes pipettes and automated pipetting systems, dispensers, centrifuges, mixers, spectrometers, and DNA amplification equipment as well as ultra-low temperature freezers, fermentors, bioreactors, CO2 incubators, shakers, and cell manipulation systems. Consumables such as pipette tips, test tubes, microtiter plates, and single-use bioreactor vessels complement the range of highest-quality premium products.

Eppendorf products are most broadly used in academic and commercial research laboratories, e.g., in companies from the pharmaceutical and biotechnological as well as the chemical and food industries. They are also aimed at clinical and environmental analysis laboratories, forensics, and at industrial laboratories performing process analysis, production, and quality assurance.

Eppendorf was founded in Hamburg, Germany in 1945 and has more than 3,100 employees worldwide. The company has subsidiaries in 26 countries and is represented in all other markets by distributors.

Press Contact: M. Anthoni Jai Kumar Eppendorf India Limited Tel: +91 44 663 12 222 anthoni.jk@eppendorf.co.in www.eppendorf.co.in

Microbioz India, December 2018

30

Market News

KayPee Udyog’s TEMPSTAR - A Brand to Trust for Every Product Requirement KayPee Udyog, an Ambala, India based organization knowing as a trusted name in the market of highprofile scientific instrument, manufacturing and supplying scientific instruments for the last 56 years with remarkable product quality and services. It came up with a brand name as “TEMPSTAR”, dealing in wide range of laboratory instruments.

KayPee Udyog is providing laboratory instrument’s in various range’s & sizes as per the requirement of the customer, currently we deals in every type of Ovens &Driers, Incubators, Blood Bank Refrigerator, Oven and Incubator Combined , Humidity Chambers, Muffle Furnace, Portable Autoclave, Water Still, Serological Water Bath, Shakers and Stirrers, Magnet Stirrers, Tissue Homogeniser, Hot Plates, Slide Warming Table, Heating Mantle, Flash Point Apparatus, Vacuum Pump, Soxhlet Extraction , Kjeldhal Distillation & Digestion, Moisture Meters, Laminar, Fume Hoods, Cabinets, Projectors & Screens, We also have multiple product related to the Pharmacy Lab Equipments such as Electronic Instruments PH Meters, TDS & Salinity Meter,

D.O.Meter, Potentiometer, Colorimeter &Homeo Globin Meter, Water & Soil Testing Kit, Microscopes, and many more other excellent products resolving your product issues with long term quality serving.

We are also certified as an ISO 9001:2015, 13485:2016, EN-12469:2000, IEC61010-1:2010 & WHO-GMP, CE Certified Company. Takes part in multiple events of laboratory and pharma to ensure that our products are reaching to multiple locations.

Whatever is your requirement we have our team every small as well as big products which are required in Laboratory and Pharma section.

For more information Mr. Rajat Jain Mob:+91-9896124839 Email ID:inquiry.kaypeeudyog@gmail.com KAY PEE UDYOG,101, INDUSTRIAL ESTATE, AMBALA CANTT, Haryana, India, Pin code- 133001

Microbioz India, December 2018

32

Business News

Chinese drugmaker pours $145M into plant with plan to produce innovative biologics A Chinese maker of heparin, APIs and some finished drugs is launching the second phase of its manufacturing plant, investing nearly $150 million as it moves into producing innovative biologic drugs for the Chinese market.

Changzhou Qianhong Bio-pharma, Tuesday announced it has started construction of the ¥1 billion ($145 million) project in the Changzhou National Hi-Tech District. It says when complete, the facility will add 200 million tablets and 60 million injections to its production, as well as making molecular diagnosis reagents.

The company said the ¥1.2 billion ($175 million) first phase produced about $155,000 in revenue in 2017.

Founded in 1971, the company says it is a major manufacturer of pancreatic kininogenase, heparin sodium and low molecular weight heparin, as well as compound digestive enzyme preparations and asparaginase used in treating some leukemia. It says some of its products are approved in the U.S., Europe and Japan.

With the second phase of its production site, Qianhong will focus on R&D of innovative and first-of-its-class biologics for China, targeting cancers and cardiovascular and cerebrovascular diseases.

Some Chinese companies are stepping up their game as they find themselves increasingly competing with western drugmakers which are producing more meds in China after the country eased rules to allow data from trials that were not done in China.

In August, China put out a target list of 48 treatments that are approved abroad, including some of the industry's biggest names, in hopes of getting drugmakers to apply for Chinese approval based on foreign trial data. The list includes drugs like Roche and Chugai’s ALK cancer drug Alecensa, psoriasis therapies Taltz by Eli Lilly, Cosentyx from Novartis and GlaxoSmithKline’s shingles vaccine Shingrix.

The news credit/source: Fiercepharma by Eric Palmer

GSK wraps up promised Horlicks sell-off in £3.1B deal with Unilever After weighing options and offers for its Horlicks drinks brand in India for several months, GlaxoSmithKline signed off on a £3.1 billion sale to Unilever. The cash will help GSK cover the cost of its Novartis consumer buy and plow more money into its newly refocused pipeline.

For the deal, worth about $3.94 billion, the companies will merge GSK Consumer Healthcare Limited with Unilever’s Indian subsidiary. GlaxoSmithKline will own part of the combined company, but plans to sell down that stake in tranches over time.

From that portion of the deal, GSK expects to pocket an eventual total of £2.4 billion. The company is eyeing another £566 million in upfront cash from Unilever in exchange for an 82% stake in GlaxoSmithKline Bangladesh Limited and other products. The companies expect the transaction to close by the end of the year. All told, the deal is expected to be worth £3.1 billion.

After weighing options and offers for its Horlicks drinks brand in India for several months, GlaxoSmithKline signed off on a £3.1 billion sale to Unilever. The cash will help GSK cover the cost of its Novartis consumer buy and plow more money into its newly refocused pipeline.

For the deal, worth about $3.94 billion, the companies will merge GSK Consumer Healthcare Limited with Unilever’s Indian subsidiary. GlaxoSmithKline will own part of the combined company, but plans to sell down that stake in tranches over time.

From that portion of the deal, GSK expects to pocket an eventual total of £2.4 billion. The company is eyeing another £566 million in upfront cash from Unilever in exchange for an 82% stake in GlaxoSmithKline Bangladesh Limited and other products. The companies expect the transaction to close by the end of the year. All told, the deal is expected to be worth £3.1 billion.

In a statement, GSK CEO Emma Walmsley said Horlicks has been an important part of the drugmaker’s business for decades, and that “Unilever is well placed to maximize its future potential.” The proceeds will go toward paying down debt and investing in GSK’s pharma pipeline, which Walmsley recently rejigged, partly to refocus on oncology. The company said Monday it would pay $5.1 billion for the cancerspecialized biotech Tesaro, which will bring along the

Microbioz India, December 2018

34

Business News PARP inhibitor Zejula, three pipeline assets and some commercial operations to support Zejula marketing.

GlaxoSmithKline started a review of the Indian consumer business in March when it agreed to purchase Novartis’ stake in the companies’ consumer health joint venture for $13 billion. During the review, potential buyers such as food company Danone, private equity firm KKR, PepsiCo and others showed interest in the Indian brands, according to various reports.

Last week, Reuters and the Financial Times reported Unilever had emerged as the lead bidder. Even as GSK offloads certain consumer brands in India, the company plans to stay involved in the Indian market.

The company plans to keep investing in OTC drugs and oral health brands in the country; Unilever will distribute those products for five years under the deal.

The news credit/source: Fiercepharma by Eric Sagonowsky

Product launch

Porvair Introduce Reservoir Troughs for Multi-Channel Pipetting

Porvair Sciences has introduced new 8- and 12-channel reservoir troughs to help improve multichannel pipetting convenience and productivity in highthroughput laboratories.

The reservoir troughs are designed to hold liquid reagents in precise rows that align with 8-channel and 12-channel pipettes allowing researchers to simultaneously aspirate or dispense fluids in all channels. These reservoir troughs help laboratories improve productivity by increasing the speed and precision that technicians are able to perform serial dilutions or dispense different reagents usinmultichannel pipettors.

Manufactured from high quality white Polystyrene or clear Polyethylene Terephthalate (PETG) the troughs are durable ensuring long-term reliable performance. The PETG reservoir troughs are autoclavable and a clear cover is available for both the 8- and 12-channel reservoirs.

The design of the new Reservoir troughs incorporates a v-shaped bottom with a residual volume of 200µL, reducing dead volume and minimizing waste. For benchtop stability, the reservoir troughs are designed to fit snugly on top of Porvair’s 96-Well Multi-Tier Base Plate. The 8channel reservoir trough has a total capacity of 56mL, with a 1mL to 7mL capacity per channel.

The 12-channel reservoir trough has a 36mL total capacity with a channel capacity of 1mL to 3mL. Steve Knight, Marketing Director of Porvair Sciences commented “Labs will find our new Reservoir Trays handy tools for adding samples, standards or reagents in high-throughput applications that involve use of multichannel pipettes”. He added “They can also be used for invitro incubation, drug-to-drug interaction and caco-2 cell applications”.

News Source and Credit : Porvair Sciences

Tomocube adds 3D Fluorescence Imaging to HolotomographyMicroscopy for World First

HT-2 microscope facilitates three-dimensional fluorescence and optical diffraction tomography of live cells with minimal stress on cells The HT-2 from Tomocube is the world’s first microscope to combine both holotomography and 3D fluorescence imaging into one unit. Capable of simultaneously capturing high resolution 3D optical diffraction tomography and 3D fluorescence images, the new microscope enables long-term tracking of specific targets in live cells while minimising stress.

The capability to easily deliver holotomography and fluorescence correlative analysis in 2D, 3D and 4D will enable researchers and clinicians to open new frontiers in bioscience and better understand, diagnose, and treat disease.

“Research and diagnosis in the life sciences depends on the information that can be found using cellular analysis,” says Aubrey Lambert, Tomocube’s Chief Marketing Officer. “Current microscopy techniques limit the quantity and quality of information available to researchers and clinicians and harm the living cells during long-term studies, but the HT-2 is set to overcome these limitations.”

The new microscope builds on the novel holotomographic technology first shown in the Tomocube HT-1, providing morphological, chemical and mechanical properties of cells through the 3D refractive index (RI) tomograms but adding molecular specificity information through the fluorescence imaging capability. The highly detailed fluorescence images show the position of specific target organelles or structures in living cells, while consecutive measurements of time-lapse 3-D RI

Microbioz India, December 2018

38

Product launch tomography enables the monitoring of cells and their structures with minimal stress.

The HT-2 incorporates a customisable three-channel LED light source (385, 470 and 570 nm) and a motorized Z-drive with a step resolution of 150 nm to generate highly detailed Z-stack images. The TomoStudio software suite controls all the functionality of the HT-2 and provides fast imaging capability and 2D/3D/4D visualization of the cellular images based on 3D RI distributions of the cells and tissues. At its core is the same patented complex digital micromirror device (DMD) optical light shaper used in the Tomocube HT-1. Consisting of several hundred thousand micromirrors arranged in a rectangular array, the DMD eliminates the need for moving parts in the lightpath and delivers stable performance during long-term studies.

Benefits Correlative microscopy in one instrument - HT-2 provides high-quality 3D images of both holotomography and 3D fluorescence for each sample.

Quantitative data marked with fluorescence - HT-2 provides morphological (volume, surface area, projection area, sphericity and ellipticity), chemical (dry mass, concentration) and mechanical (cell deformability) properties of cells with 3D refractive index (RI) tomogram. Moreover, fluorescence image provides information about molecular specificity.

Live cell molecular and holographic imaging with minimal stress on cells - Simultaneous measurement capability of time-lapse 3-D RI tomography and fluorescence image allows long-time tracking of specific targets in live cells. The fluorescence image provides the position of specific target organelles or structures in live cell, and consecutive measurements of time-lapse 3-D RI tomography enables the monitoring of cells and their structures with minimal stress.

News source / Credit: Tomocube

Syngene Introduces Next Generation G:BOX Imaging Systems

Featuring a Super-sensitive Lens for Quick, Accurate Imaging of all Gels and Blots Syngene, a world-leading manufacturer of image analysis solutions, is delighted to announce its new generation G:BOX Chemi XX6/XX9 multiapplication imaging systems are now available.

Featuring the latest, ultra-sensitive, fast capture lens, these systems ensure scientists can have total confidence that their gel and blot results are accurate and publication-ready.

Utilising a state-of-the-art wide aperture f0.8 lens, the camera in the next generation G:BOX Chemi XX6/XX9 systems can capture more light, which means scientists can use shorter excitation times when imaging IR and R,G,B fluorescence blots and gels, thus reducing photobleaching and generating more accurate results. The high-performance lens also speeds up chemiluminescent imaging and lowers reagent costs by reducing the amount of expensive antibodies needed to visualise bands.

The super-sensitive lens combined with unique motorised stage in the G:BOX Chemi XX6/XX9 systems also captures sharp, true to life images allowing researchers to resolve close chemi and fluorescent bands and visualise bright and faint bands on the same image. Since the results are optical and not just digitally enhanced, scientists can be certain the bands they detect are real, making these systems ideal for precisely quantifying DNA and proteins down to the femtogram level on a range of gels and blots.

Designed to be future-proof, the new G:BOX Chemi XX6 and XX9 systems have a clever gantry which can be fitted with Syngene’s R,G,B and IR HiIntensity lighting options (up to 200 times brighter than standard LEDs) and new lighting options as they become available. This allows scientists the flexibility to add their choice of illumination and excitation to detect multiple fluorescent channels on multiplex gels and blots, as well as image close bands or spots on complex 2D gels.

Microbioz India, December 2018

40

Product launch Complete with GeneSys image capture and GeneTools image analysis software, the G:BOX Chemi XX6/XX9 systems include a total protein normalisation feature, ensuring scientists can confidently generate publication-compliant images of chemi, multiplex fluorescence blots, DNA and stain-free protein gels every time.

“The feedback we have had from talking to scientists worldwide is that they want easy to use equipment which has fast IR fluorescence and chemi image capture times, yet produces true to life images,” says Dr Martin Biggs, Sales Manager at Syngene “We’ve responded by integrating one of the world’s best in class lens into our G:BOX XX6/XX9 systems and now, without having to become an imaging expert, any researcher using this technology will get great imaging performance with results they can trust.”

News Source and credit : Syngene

Next Generation FTIR Spectrometer Features Newly Engineered Optical System

Thermo Scientific Nicolet iS20 FTIR spectrometer enables analytical scientists to experience advanced performance and data analysis.

Analytical scientists and laboratory managers seeking high-performing, multi-functional instruments with low cost of ownership can now benefit from a new FTIR spectrometer designed to analyze complex samples quickly and deliver fast, accurate results.

The Thermo Scientific Nicolet iS20 FTIR spectrometer, which is an upgrade over the wellestablished Thermo Scientific Nicolet iS10 FTIR

spectrometer, features new LightDrive Optical Engine technology. The redesigned optical system consists of four critical components – an infrared source, interferometer, laser and detector – to deliver exceptional instrument performance and reliability.

The new instrument enables analytical scientists in pharmaceutical, polymer, chemical and forensics labs to identify unknown compounds, verify incoming materials, conduct failure analysis and conduct root cause studies by easily collecting and interpreting FTIR data. It is the only spectrometer on the market that features a touch panel with a multi-colored LED scan bar; the touch panel is designed to assist data collection from even the most challenging samples and help users understand their instrument status at a glance.

"With our newest FTIR spectrometer, busy laboratories facing tight budgets can improve their analytical capabilities while remaining on a familiar and comfortable instrument platform," said Matt Gundlach, product manager, FTIR spectrometers for Thermo Fisher Scientific. "The Nicolet iS20 spectrometer allows scientists to decrease the time from analysis to result, providing an improved user experience over previous-generation Thermo Scientific instruments."

Additional benefits of the Thermo Scientific Nicolet iS20 FTIR spectrometer include:  Cloud-based spectroscopy software with improved functionality that allows students and scientists to analyze their data anytime and anywhere.  The ability to interface easily with external modules, including the Thermo Scientific Nicolet iN5 and Continuµm infrared microscopes.  A 10-year warranty on three critical optical components (laser, interferometer, and source).

News Source / Credit : Thermofisher Scientific

Applied Photophysics Signs Distribution Agreement with Particular Sciences to Expand Coverage in Europe Distributor will supply Chirascan circular dichroism spectrometers and SX stopped-flow spectrometers to Ireland and Northern Ireland Applied Photophysics, a leading provider of systems for biophysical characterization of biomolecules, has announced that it has signed a distribution

Microbioz India, December 2018

42

Product launch agreement with material characterisation specialist, Particular Sciences. The distributor will supply industry and researchers in both Ireland and Northern Ireland with Applied Photophysics’ Chirascan™ circular dichroism (CD) systems and SX-range of stopped-flow spectrometers. This latest agreement further expands the Company’s presence throughout the EU market, after recently signing with similarly well-established and experienced scientific equipment distributors in Italy, Portugal and Spain.

Applied Photophysics’ current product portfolio includes the Chirascan platform, which uses CD to reveal changes in the higher order structure and stability of proteins - essential in cutting-edge research and during the development of innovator drugs and biosimilars, and the SX-range of stoppedflow spectrometers, used to monitor changes in absorbance and fluorescence for gold-standard kinetic studies of fast biological reactions.

Louise Madden, CEO, Applied Photophysics, said: “The agreement to extend the distribution of our CD and stopped-flow instrumentation to Ireland and Northern Ireland ensures that our customers receive support closer to home, whilst further demonstrating our significant growth plans in order to scale-up operations and coverage as a company.”

Sean Quilty, Founder and Director, Particular Sciences, said: “For 29 years, Particular Sciences’ mission has been to maintain excellence in material characterisation technologies, and to deliver the highest quality technical support to our customers in Ireland and Northern Ireland. Now serving over 250 companies, and representing a select group of specialist companies, we are proud to provide our customers the latest characterisation technologies, such as Applied Photophysics’ new generation of Chirascan CD systems.”

News source and Credit: Applied Photophysics

New Electronic pipette controller

The new generation pipette controller Profiller™ electro 447 is ideal for working with glass or plastic

pipettes. Its compact shape fits any hand in a very comfortable way enabling trouble free work within laminar flow or microbiological safety cabinet.

Liquid aspiration and dispensing are performed through two ergonomically positioned finger triggers, requiring minimum activation effort. One switch enables instant selection of working speeds.

The slow activation is needed when handling volumes below 10 mL. For large volumes, even over 100 mL, the efficient fast speed greatly shorten handling time.

Each working mode is clearly indicated on the digital display, providing compatibility with both “to deliver” and “blow-out” pipette types.

Battery charge level is visible anytime on instrument display. For maximal working flexibility, recharging batteries is possible either in storage position (plug connected to bench stand) or during use (plug connected to instrument).

News Source and credit: Socorex Isba S.A.

New circulating cooler with CO2 refrigerant

Environmentally friendly cooling with carbon dioxide With the new Unichiller 250w CO2, Huber Kältemaschinenbau presents another milestone in environmentally friendly refrigeration technology.

The new chiller uses CO2 as a refrigerant. CO2 or carbon dioxide (also known as R744) is a natural component of air and has been proven in refrigeration since the 19th century.

The colorless gas liquefied under pressure, has no ozone depletion potential (ODP = 0), and has a negligible greenhouse gas potential with a GWP = 1.

If, for example, 1 kg of CO2 enters the atmosphere through a leak in the refrigerating circuit, this is 3780 times less damaging than with the conventional refrigerant R404A. In addition, CO2 is a so-called natural refrigerant which occurs in very large quantities in nature, i.e. it does not have to be generated with great energy expenditure. In addition, CO2 is non-flammable, non-toxic and chemically inert.

Microbioz India, December 2018

44

Product launch The new Unichiller CO2 is therefore a 100% environmentally friendly alternative to refrigerators with conventional synthetic refrigerants. The Unichiller is designed for working temperatures from -20 to +100°C, and offers a cooling capacity of 25 kW and a heating capacity of 12 kW. The circulation pump achieves a delivery rate of 220 l/min and 4.7 bar pressure. The cooler is equipped with the Pilot ONE touch-screen controller and therefore has numerous professional functions for

Silicone Diaphragms by Ami Polymer Pvt. Ltd.

demanding temperature control tasks.

Advantages:  Proven Unichiller technology  Environmentally friendly refrigeration technology  Ozone depletion potential equal to zero (ODP = 0)  Global warming potential negligible (GWP = 1)  Very good energy efficiency  Refrigerant non-flammable, non-toxic  High operational safety  Whisper-quiet operation (just 60 dB)  Future-proof investment (not affected by the F-gas regulation) News source and Credit: Huber

Medical-grade, platinum cured silicone is widely accepted in pharmaceutical and biotech applications and is often used throughout the plant. Like all of our diaphragm materials, silicone diaphragms meet USP Class VI and FDA 21 CFR 177.2600 standards.

It is suitable for Biomedical/Pharma application. All diaphragms meet the standards for quality, purity, lack of toxicity, strength & consistency Ami Polymer Pvt. Ltd. 319, Mahesh Industrial Estate, Opp. Silver Park, MiraBhayander Road, Mira Road (E), Thane - 401104, Maharashtra. INDIA Tel.: +91 22 28555 107 / 631 / 914 | Cell: +91 86910 13935 Email: mktg@amipolymer.com | Web: www.amipolymer.com

Sponsored Post

Skytech Systems India Pvt Your trusted partner in delivering complete instrumentation solution for Analytical labs /Process Development & Safety /Spectroscopy /Validation...

Skytech Systems India Pvt Ltd is the leading Instrument Distribution Company since 25 years of experience in this field. Our technologies & services have become our important asset. We guarantee our customersto serve them right product&services for all their needs.

We have been the distributors of Kaye validation& TOC Analyserfor more than decades.

Through these long years of experience, we understood the application needs of the customers for instruments small accessoriesrequirements & reference material which make instrument robust.

So we are promoting below accessories.

Note: BI options are available only for sizes greater than 1.0 inch

Biological Indicators

Spore Trap Gasket

Smart Gaskets Type Smart Gaskets

colour

Silicone EPDM

Black

Teflon (PTFE)

White

Viton (Flourel)

Temperature

Available Size

-58 to 446°F (-50 to 230°C).

0.5”,0.75”,1.0”, 1.5”.2.0”

-65 to 212°F (-54 to 100°C).

-450 to 550°F (-268 to 288°C).

0.5”,0.75”,1.0”,1.

5”.2.0” 0.5”,0.75”,1.0”,1.

5”.2.0”

Smart Gasket/Ported Gasket

PTFE Orifice Gasket

Ports 1,2,3,4

Biological Indicator Option Stripe ,vials Stripe ,vials

-25 to 400°F (-32 to 204°C).

Sanitary Clamps

Vials Capping for Validation Study

Skytech offers a variety of clamps for any application.

Whether it is a single pin sanitary hinge clamp or a slotted clamp for a spore trap, all of your clamp needs are covered here.

Placement of the Sensors in thermal validation in sterile process plays a critical role because the thermocouple should be placed exactly at cold spot to get the lowest lethality in penetration study. Even in the container mapping also the sensors need to be placed at different altitudes inside the same vial.

Microbioz India, December 2018

47

Sponsored Post Understanding the criticality Skytech system introduced different kinds of fittings to suit your requirement of sensor placement, this ensure the Sensor kept at particular position &remains in the same position throughout the study. Based on the sensor diameter, vial neck dimension the suitable vial caps can be chosen. Based on the application MOC of the Vial Cap can opted either SS or Teflon.

Altus Science Limited-UK

TOC-Certified Reference Material& Consumables CRM/Consumables focus on Total Organic Carbon &conductivity. Our CRM were successfully assessed by UKAS and audited to both ISO 170235 & ISO Guide 34 & it is ready to use vials with liquid volumes ranging from 30ml to 50 ml.

TEL-022-41533342,FAX-022-41533388,Emailmarketing@skytechindia.com,Websitewww.skytechindia.com

Nextgen Breakthrough Polymer: FFKM Rubber parts Unispares® perfluoroelastomer (FFKM) parts withstand attack from more than 1,500 chemicals, solvents and plasmas. Unispares® product range delivers outstanding performance in aggressive process conditions and operating parameters.

Whether it’s resistance to acids, amines, plasma, ultrapure de-ionized water or strong bases, by

selecting the Unispares® product that is best suited to a specific application, manufacturers can improve seal performance in their operating environment.

Unispares® Application engineer can help users select the preferred product for temperature and chemical resistance. Unispares® perfluoroelastomer (FFKM) parts have proven to be breakthrough in areas where traditional Polyrub compounds fail to operate.

FFKM Rubber Parts improve the productivity and performance in application areas there by having a lasting impact in overall engineering and production operations.

Range of our FFKM products include: Unispares® FFKM O Rings Unispares® FFKM Gaskets and Washers Unispares® FFKM Tubings Unispares® FFKM Customised Equipment parts

Feel free to contact our area representative.

Thanks, Arihant Jain | +91-9490934575 CEO-Director | PGDM IIT Madras Unispares Polymer Industries Pvt. Ltd.

Microbioz India, December 2018

49

RNI NUMBER: UPENG/2017/73675