John A. Moran Eye Center Focus 2021

John A. Moran Eye Center | University of Utah Health

FOCUS 2021

HOPE UNDERSTANDING

TREATMENT NOW MORE THAN EVER

 RESEARCH

 PAT IE N T C A R E

 OUTREACH

 E D U C AT IO N

CONTENTS

2

Chair Message

An Enduring Vision

Tribute

4

Honoring Alan S. Crandall, MD

Research

14 New Hope in the World’s First ‘Pathoconnectome’ Research

18 Reading the Language of the Eye Research

20 Preventing Blinding Disease in

Premature Babies

Research

Patient Care

21 Shedding New Light on Human

Color Vision 22 The Rise of Teleophthalmology

Official Publication of the John A. Moran Eye Center University of Utah Health, Salt Lake City, Utah 84132 John A. Moran Eye Center 65 Mario Capecchi Drive Salt Lake City, Utah 84132 801-581-2352

CO-EDITORS Anna Cekola, Communications Editor Elizabeth Neff, Director, PR, Communications, Marketing

EXTERNAL RELATIONS TEAM/CONTRIBUTORS Natalie Lam, Administrative Assistant Tawnja S. Martin, Development Officer Heidi G. Reid, Director of Development Dinny Thayne Trabert, Senior Major Gift Officer Lynn Ward, Executive Director, External Relations Thomas Whitworth, Development Officer

CONSULTANTS

PRINTING

Virginia Rainey, Writer/Editor Catherine Reese Newton, Copy Editor

Printers Inc., Salt Lake City, Utah

GRAPHIC DESIGN Spatafore Design

PHOTOGRAPHY Michael Schoenfeld, Major Portrait Photography James Gilman, CRA, FOPS Matthew Hepworth Toniee Lewis Scott Peterson

A special thanks to the many hard-working Moran Eye Center employees, management, health care workers, physicians, patients, and researchers who generously contributed their time and talent to make this publication possible.

Research work highlighted in this publication was supported by an Unrestricted Research Grant from Research to Prevent Blindness, New York, NY, to the Department of Ophthalmology & Visual Sciences, University of Utah. ©️2021 John A. Moran Eye Center. All rights reserved. The Moran Eye Center does not assume responsibility for any representation therein, nor the quality or deliverability of the product itself. Reproductions of articles or photographs, in whole or in part, contained herein are prohibited without the publisher’s express written consent, unless otherwise stated.

FOCUS

JOHN A. MORAN EYE CENTER

Patient Care

Patient Care

Donor Profile

24 When the World Paused, Moran Didn’t 26 Understanding and Help for Vision Loss 28 Dr. Ezekiel R. and Edna Wattis Dumke Foundation Outreach

30 There for Utah Outreach

32 Thinking Globally, Acting Locally

Outreach

34 Confronting the Growing Problem of Worldwide Blindness Education

35 Connecting Fellows to Advance Global Ophthalmology Education

38 Supporting Student Physician-Scientists

36 |

Residents and Fellows 2020-2021

39 |

Highlights: Awards and Honors

43 |

Ophthalmologists 2020-2021

49 |

Optometrists 2020-2021

50 |

Research Team 2020-2021

53 |

Adjunct Research Team and Volunteer Ophthalmologists

54 |

Donors Fiscal Year 2020

62 |

Moran Eye Center Profile

64 |

Last Look

65 |

Moran Eye Center Community Clinics and Services

MESSAGE FROM THE CHAIR

An Enduring Vision

When we created a vision statement many years ago, Alan S. Crandall, MD, and I knew our colleagues might view it as overly ambitious.

Unrealistic. Audacious.

Who were we, a little eye center in Utah, to say we intended to create a world where no one is left behind? That no one with a blinding condition, eye disease, or visual impairment should be without hope, understanding, or treatment?

But that statement was—and continues to be—a leap of faith.

It was the world as we imagined it could be and a guiding light for our efforts. It was one of many, many ways Alan shaped

2020-202 1 MOR AN

ADVISORY COUNCIL

the culture of Moran. Together, Alan and I vowed to embrace new technologies, to empower the people who worked for us, and to always hire the best person for the job.

Throughout his 39 years at Moran, Alan personified our vision and ideals. The past year challenged us all in new ways.

Yet we had Alan’s unwavering example to follow.

During the pandemic’s shutdown, we quickly implemented a battery of protocols to safely treat patients in danger of losing their sight without our care. We also ramped up telehealth to protect those most at risk.

When COVID-19 curbed our international outreach efforts, Alan and the program he created continued to provide care locally and expanded to form new community partnerships.

Toni Bloomberg La Jolla, California

Thomas “Tim” Dee III Salt Lake City, Utah

William “Bill” Child Salt Lake City, Utah

Christena Huntsman Durham Salt Lake City, Utah Spencer F. Eccles Salt Lake City, Utah

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We initiated a needs assessment to learn how we can better serve Utahns unable to access eye care. And a new endowed directorship funded by the Dr. Ezekiel R. and Edna Wattis Dumke Foundation will help take the program to new heights.

This issue of Focus acknowledges the profound loss of Alan’s unexpected passing in October 2020. His generous spirit and exceptional mind were the heartbeats of our institution.

But make no mistake: His death is not the end of our collective willpower but a rallying cry for those of us who remain to follow his example. It is up to us to continue his amazing legacy. Our calling could not be more apparent, and I am indescribably proud of the faculty and staff building on the foundation Alan created.

When the time is right, we’ll hold a real blowout to celebrate Alan’s life and legacy. It will be a party to remember, one that he certainly would have been the life of.

Alan, we dedicate so many of our past achievements and our bright future to you, dear friend. As you would often say, “Let’s get on with it.”

Sincerely,

Randall J Olson, MD Professor and Chair, Department of Ophthalmology and Visual Sciences CEO, John A. Moran Eye Center, University of Utah

Christine A. Fairclough Salt Lake City, Utah

John A. Moran Palm Beach, Florida

John E. Warnock, PhD Los Altos, California

Wayne A. Imbrescia John A. Moran Eye Center

Randall J Olson, MD John A. Moran Eye Center

Norm A. Zabriskie, MD John A. Moran Eye Center

Claudia S. Luttrell Salt Lake City, Utah

Lynn Ward John A. Moran Eye Center 3

ALAN S. CRANDALL, MD June 13, 1947 — ­ October 2, 2020

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Life —Well Lived

A GENEROUS

Alan S. Crandall, MD, embodied Moran’s vision to provide hope, understanding, and treatment.

The passing of our beloved friend and extraordinary colleague, Alan S. Crandall, MD, on October 2, 2020, left all of us here at the Moran Eye Center with heavy hearts.

As word spread, those feelings resonated the world over. Messages poured in from India, Ghana, Nepal, and beyond. Global outreach partners, former residents and fellows, donors, and professional ophthalmological societies offered moving tributes.

Patients whose lives were changed by his brilliant surgical skills sent touching memories and deepest thanks.

We are forever grateful to all who were touched by this giant of ophthalmology and humanity and took the time to let us know.

For nearly four decades, Crandall’s ever-present enthusiasm and consideration for his colleagues shaped a culture of family at Moran. He was equally passionate about his patients’ care, teaching, and humanitarian outreach. He excelled at it all, and each aspect of his life spawned more tales than we could ever tell.

As a renowned surgeon and teacher, the professional honors he accrued were legion, but so are the personal stories. Over and over, friends and colleagues describe him as the embodiment of kindness and as a joyful spirit who made you feel you were the most important person in the world.

Every little bit you can do to help can make a big difference in the long run.

I really believe that.

—AL AN S . CR AN DALL , M D

“Alan’s contributions to our field are absolutely immeasurable,” said Moran CEO Randall J Olson, MD. “Those he taught and influenced in deeply profound ways are numberless. He was revered as one of the greatest glaucoma, cataract, and anterior segment surgeons in our lifetime. Yet that’s not the most amazing thing about him.

He was also the kindest, most humble, unassuming person you could ever hope to know.”

Alan S. Crandall, MD, held the John E. and Marva M. Warnock Presidential Endowed Chair of Ophthalmology and Visual Sciences. He served as Moran’s senior vice chair, director of glaucoma and cataract, and senior medical director of the Global Outreach Division.

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A MASTER

Surgeon & Physician

When you go into the operating room, examine the patient and have a game plan.

But you’d better also have game plan A, B, C, and D, and you should be able to do all of them.

—ALAN S. CRANDALL, MD, IN TH E OPHTHALMOLO GIST Crandall grew up in Salt Lake City in a family dedicated to community service. As the son of one of Utah’s first ophthalmologists, he recalled accompanying his father to the original St. Mark’s Hospital, where some of his father’s patients paid him on the barter system. “It wasn’t unusual to receive a chicken instead of cash,” Crandall said. “My father’s philosophy was that he would treat

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everybody the same way. As far as I could tell, he had no prejudice against anything other than stark stupidity. He was true to his word—he worked hard and loved what he did.”

Crandall attended Salt Lake’s Judge Memorial High School, where he became a football hero despite his relatively small stature. He was also an expert skier and

loved to play basketball. He received his bachelor’s and medical degrees from the University of Utah and completed a surgery internship at Pennsylvania Medical Center and residency and a glaucoma fellowship at Scheie Eye Institute in Philadelphia.

A superb surgeon who made it his mission to learn new skills, Crandall was also a remarkable innovator. Long before it became the modern standard of care, he adopted the method of phacoemulsification for removing cataracts and taught it to others.

Alan Crandall with his father.

He led the way in adopting small-incision glaucoma surgery, known as MIGS. Wielding microscopic-sized equipment to make tiny incisions, his skilled hands helped avoid countless complications in daunting situations. His success with complicated anterior segment (front of the eye) surgery is legendary.

Crandall also invented several surgical techniques and participated in numerous research studies that improved his patients’ lives. Most recently, that had included translating surgical techniques developed for adults into pediatric cases to improve outcomes.

“Alan made it a core principle that we would never be close-minded about new surgical techniques and tools, that we would always be open to what was out there,” said Olson. “And, from early on, he wanted every surgery recorded. His analysis became part of our ‘continuous quality program’ where he would take the time to sit down and review each one. He would do a root-cause analysis for each complicated case, trying to understand what may have gone wrong. He just never quit, and he shared his experience on the national and international stage.”

Among the many honors bestowed throughout his career, Cataract and Refractive Surgery Today named Crandall as one of 50 international opinion leaders. The Ophthalmologist recognized him as one of the 100 most influential people in the ophthalmic industry. He was a past president of the American Society of Cataract and Refractive Surgery. Crandall also served as a diplomate of the National Board of Medical Examiners and the American Board of Ophthalmology.

“We are devastated. He did my surgeries 35 years ago. When I was little, I would see him down the hall and run to his outstretched arms.

Thirty-five years later, and we still ended the visit with a hug. He also saved my son’s vision. He’s a miracle worker. I always called him my second dad. He will be greatly missed.”

—Erin Merill Kirby, patient

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“He was my ophthalmologist, but more than that, he was my friend.”

—Glenn Clapp, patient

“We owe him so much. He loves looking at our unique eyes! He has operated on us both multiple times. … Dr. Crandall cares so much about everyone.”

—Dale and Chris McMillan, patients

“Dr. Crandall did his best to help me through and did everything he could to try to restore my vision years ago. Even though little headway was made, I gained a friend, and he still did what he could and was supportive of me as I adapted to it.”

—Taylor Cline, patient

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BOUNDLESS COMPASSION While his surgical talents reached legendary status and improved the lives of thousands of patients, Crandall’s innate ability to connect with patients placed him in a category of his own.

“His connection with his patients was a thing of beauty,” said Norm Zabriskie, MD, Moran’s vice chair, medical director of clinical service, and executive director of clinical operations. “He made sure he connected with each one of them at every visit. And I don’t mean just about fishing, or food, or travel, but I mean connected in the most important

way—one that said he was going to do everything he could to help them keep seeing and have the best outcome possible.”

Moran colleague Bradley J. Katz, MD, PhD, described Crandall’s unique blend of surgical and people skills: “I’ve learned so much from Alan. Not just surgery, where he’s saved my bacon more than once, but also how to be kind to patients, staff, and colleagues, giving of advice and assistance without any expectation of receiving anything in return, and helping those in need.”

Mary Elizabeth Hartnett, MD, who directs Moran’s Pediatric Retina Center, said she always thought of Crandall “whenever I performed a novel or challenging surgical procedure or task. I knew he would plug on and continue, so I could also. I will always remember his kindness, his support, and his strength and believe he would want us all to push ahead in gaining the knowledge to best serve our patients.”

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TIRELESS

Humanitarian “The work we do improves the life of the patient. We gain new friends; we always learn from other cultures. It keeps me humble and happy to know I’m helping to make a difference.”

—AL AN S . CR ANDALL , MD

The founder and senior medical director of Moran’s Global Outreach Division, Crandall began his now-legendary outreach work in Kumasi, Ghana, more than two decades ago. He traveled there in response to a request from a longtime patient who had family ties in that region.

She told Crandall about the lack of ophthalmologists and the dire need for eye care, including curable blindness from cataracts, and asked him to do what he could to help. True to his nature, he said, “OK, let’s do it.”

“Alan has dedicated his career to humanitarian service, and his loving, generous spirit permeates all that he 10

does,” said renowned cataract surgeon and American Society of Cataract and Refractive Surgery (ASCRS) Foundation Co-Chair David Chang, MD, in awarding Crandall the inaugural ASCRS Foundation Chang Humanitarian Award.

“The list of places where Dr. Crandall has given his time and skill is long and varied, including Ghana, Ethiopia, South Sudan, Nepal, India, China, Guatemala, Tonga, Haiti, Micronesia, and Cuba, as well as regular service on the Navajo Nation,” said Chang. “The nature of these outreach efforts is as impressive as the list itself.”

Alan and his wife Julie Crandall often volunteered together on international outreach trips.

The stories of Crandall working in makeshift operating rooms around the world, often in searing temperatures, and sometimes amid an array of tropical “visitors” in the form of bugs and bats, are seemingly endless and occasionally harrowing. Whatever the story, common threads emerge. Colleagues talk about his phenomenal stamina and enthusiasm. They recount how he always logged the highest number of procedures, hardly pausing, and never saying “no” to any challenge—whether it was continuing long past quitting time or dancing through the night. And all this despite screws in his neck, which he broke twice—the first time while skiing. The second came on a bumpy bus ride in Ghana when a 40-pound phaco machine dislodged from the luggage rack and hit the back of his neck. Later, he acquired two artificial knees and an artificial hip.

Though he was humble, Crandall wasn’t above the “humblebrag,” but always with a smile.

He was also known for his bolo ties, which he started wearing when he figured out he was “not the bow-tie type” while on the faculty at the University of Pennsylvania in the 1970s.

Crandall was the only person to receive four internationally recognized awards in ophthalmology for his outreach work: the American Glaucoma Society Humanitarian Award, the American Academy of Ophthalmology Humanitarian Award, the ASCRS Humanitarian Award, and the inaugural ASCRS Foundation Chang Humanitarian Award.

“In his too short, but amazingly full life, Alan held so many of our hands, brought joy to our journeys through life and helped us reach where we needed to go.”

—Geoff Tabin, MD, co-founder, Himalayan Cataract Project

“Alan Crandall was not only a world-famous cataract and glaucoma surgeon but a great humanitarian,” said R. Venketesh, chief medical officer of Aravind Eye Hospital in Pondicherry, India. “He is truly an inspirational human and physician.

For many of us at Aravind, he was a great friend, philosopher, and guide. He strongly believed that training doctors in resource-poor countries is the main solution for eradicating needless blindness.”

“Despite his celebrity status, Alan was approachable by all. He was warm, kind, selfless, and a man of total integrity.”

— Robert Osher, MD, director emeritus of the Cincinnati Eye Institute

“I had the honor of being Alan’s friend and a partner in his plan to change the world. He was my true north. I feel a bit lost, like all of us.

But I still hear him when I operate or push myself to be brave, and he is telling me to keep walking. Like most corneas, this fog is going to clear.”

—Susan MacDonald, MD, associate clinical professor, Tufts University School of Medicine; president, EyeCorps

David Chang, MD, left, and Alan S. Crandall, MD, at the ASCRS Foundation Chang Humanitarian Award ceremony.

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Lifelong Teacher An exacting teacher and mentor, Crandall aimed to produce the finest surgeons possible. He took special pride in seeing his students excel and become leaders in the field.

“To watch his quiet hands performing surgeries was to see a master at work.

If I see a surgical video anywhere in the world, I can tell if it’s someone who trained with Alan because of a few subtle things he taught,” said Jeff Pettey, MD, MBA, Moran’s vice chair of education.

John Berdahl, MD, of Vance Thompson Vision in Sioux Falls, North Dakota, and a Moran adjunct volunteer ophthalmologist, first learned of Crandall during residency at Duke University. He had heard of Crandall’s legendary skills—and that he had a reputation of sometimes intimidating his residents and fellows.

“Lower your hands.

You can’t cheat physics.

You can remove more than one molecule of lens at a time.

A surgery should be elegant and appear effortless.”

—AL AN S . CR ANDALL , MD , TR ADEMARK PHR AS ES TO RESIDENTS IN TR AINING

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“But I know he also made his Utah residents bulletproof,” he said. “Instead of feeling intimidated when I met him, I found he had a unique ability to inspire from afar and pull out the absolute best from those he was close to. His residents, including my colleague, Russell Swan, MD, a former Moran resident and current Moran adjunct volunteer, knew his admonitions came from a place of love and enabled them to hone skills they would carry with them for a lifetime.”

Colleagues worldwide praised Crandall’s way of clearly explaining complex surgical topics in ways that even non-surgical ophthalmologists could understand. Whenever physicians, technicians, or staff around him had questions or needed assistance, he stepped up to help.

“He understood that giving someone the confidence to handle challenging cases was just as important as training their hands to produce the proper movements,” said Roger Furlong, MD, Moran adjunct volunteer ophthalmologist and glaucoma specialist in Butte, Montana.

“He understood that being a good physician meant more than knowledge or technical skill.”

Said Moran colleague Nick Mamalis, MD, who traveled the world with Crandall: “What I think is important about Alan is that he has not only done

a tremendous amount of work internationally performing cataract surgeries, but also was involved in teaching others in the developing world and creating mechanisms to show other surgeons how to do these procedures and perform them elsewhere.

“It is one thing to fly in and fly out of remote locations, but it is another to set up the mechanisms to educate medical teams. It’s like the adage: Give a man a fish and you feed him for a day. Teach a man to fish and you feed him for a lifetime.”

HUMANITARIAN AWARD HONOR David Chang, MD, and the American Society of Cataract and Refractive Surgery Foundation in 2020 renamed their humanitarian award to bear Crandall’s name in honor of his exemplary life and commitment to charitable service: the 2021 ChangCrandall Humanitarian Award.

MORE PHOTO AND VIDEO TRIBUTES ONLINE bit.ly/AlanCrandall

“He was my one and only mentor.

I am who I am because of him, and any success I have is from his inspiration and guidance. It was a privilege to study under him as his fellow and continue to work together in surgery, clinic, research, conferences, and around the world.”

— Iqbal “Ike” Ahmed, MD, FRCSC, Kensington Eye Institute, University of Toronto, and former Moran fellow “Many of the most skilled anterior segment surgeons we know today owe their expertise to Alan’s efforts.”

—Robert Cionni, MD, Eye Institute of Utah “He was my teacher of towering proportions who inspired me and gave me courage and cautious confidence in approaching surgical glaucoma.”

—Abba Hydara, former ophthalmic trainee now a glaucoma specialist and health care leader in Gambia 13

 RESEARCH

NEW HOPE IN THE

World’s First ‘PATHOCONNECTOME’

A map of retinal disease generated by Moran’s Marclab for Connectomics offers a deeper understanding of a host of neurodegenerative diseases.

As Rebecca Pfeiffer, PhD, points to a 2-D image produced by a transmission electron microscope, her excitement is palpable.

“That’s one of the most gorgeous I’ve ever seen,” said Pfeiffer, a research associate in Moran’s Marclab for Connectomics directed by Bryan W. Jones, PhD. It’s a green blob and a blue blob with a tiny gap of space between them to the untrained onlooker. But Pfeiffer can explain it as a revelation three years in the making.

The blobs are neurons in the retina of the eye. The green one allows us to detect darkness—the blue one, light. And the gap of space between is actually a new connection formed between them.

The two types of neurons shouldn’t be able to communicate with each other, but in retinal disease they do. Data from 946 retinal tissue samples is clear: The rewiring is a previously unknown way a disease-stricken eye keeps trying to do its job.

A 2-D pathoconnectome image showing two retinal neurons (rod bipolar cell in blue, Aii amacrine cell in green). Yellow spots indicate locations of gap junctions. These junctions, shown at the arrow in the inset image, formed to allow electrical communication between the two neurons as the degenerating retina rewired itself during disease.

“There are several rules in the way neurons can connect, and these two didn’t have the right proteins to do that,” Pfeiffer said. “So seeing that these cells are making a whole new type of connection is really, really surprising.”

The discovery was one of many made as the Marclab in 2020 published the world’s first “pathoconnectome,” or map showing how the retina rewires itself in disease. The pathoconnectome was the next historic chapter for a lab that, in 2011, became the first to publish a connectome detailing the circuitry of a healthy retina.

A MODEL FOR MANY DISEASES The lab developed the pathoconnectome from a model of early-stage retinitis pigmentosa (RP), an inherited retinal disease that can lead to blindness. RP impacts 1 in 4,000 people, and symptoms begin as a person starts to have difficulty seeing at night. The change progresses to a loss of peripheral and daytime vision as more retina cells start to die.

Yet the promise of the pathoconnectome extends far beyond one rare eye disease.

It offers the potential to be used as a model to study a host of neurodegenerative diseases that attack the body’s central nervous system, such as Alzheimer’s, Parkinson’s, epilepsy, and amyotrophic lateral sclerosis (ALS).

Rebecca Pfeiffer, PhD, is a research associate in the Marclab for Connectomics who spearheaded the development of the first pathoconnectome.

“The components of neurodegeneration we see in the eye seem to mimic those we see in the brain,” explained Pfeiffer. “A pathoconnectome allows us to learn how neurodegenerative diseases alter neural networks in general. The ultimate goal is to identify how we might develop new therapies based on preventing or interfering with the network rewiring that happens during disease.”

The Marclab is now working to produce two more pathoconnectomes that will show how rewiring occurs in later stages of RP. “For our first pathoconnectome, we wanted to focus on the earliest stage of disease we could because there are real implications for being able to rescue eyesight if therapies are developed at that point,” said Jones. “We had data going back years suggesting changes start really early, so we deliberately picked an early timepoint with the hypothesis that rewiring changes were already happening.”

The hypothesis was proven: The team found far more extensive rewiring than expected— so much so that scientists had to identify, classify, and understand connections never seen before in the eye.

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Bryan W. Jones, PhD, with his lab’s second and newest transmission electron microscope, recently gifted by the Lawrence T. & Janet T. Dee Foundation.

A DATING GAME

CONTINUING THE WORK

Pfeiffer found that neurons are reaching out continually to seek new inputs and partners in the face of disease.

Since the first pathoconnectome has been completed, the second and third should be faster to construct. The lab could finish the second as soon as the end of 2021.

“One of the main things we were looking at is as these cells degenerate, what happens to their downstream partners in the eye,” said Pfeiffer. “What we find is they make new partners. But what are the rules for that? How do they make new partners, and what sorts of partners do they tend to try to find?”

For Pfeiffer’s curious mind, connectomics is the perfect research area, although she continues to work in metabolomics, or the study of small molecules.

“The world is a really, really big place, and I’m working on these tiny, tiny pieces of it that I just can’t put together yet,” she said. “I don’t think that anyone who works in connectomics for more than three months can walk away from it again because there is just more to know. It’s a really fun puzzle, and I want to put the next piece in.”

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Like its predecessor, the pathoconnectome data set has been open-sourced for use by other scientists around the world.

“There is so much data, no one lab could mine it all,” said Jones.

“We’re not so much interested in fame as we are in creating a body of knowledge that can be used for epiphany moments in several other fields, like electrophysiology or genetics. Connectomes are a discovery tool.”

Now, researchers around the world can use the data to begin to ask their own questions. In the myriad answers will be new hope.

ABOUT THE PATHOCONNECTOME STUDY In addition to Pfeiffer and Jones, 11 other Marclab researchers are authors on the new pathoconnectome publication, titled “A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration.”

They are James R. Anderson, PhD; Jeebika Dahal; Jessica C. Garcia; Jia-Hui Yang; Crystal L. Sigulinsky, PhD; Kevin Rapp; Daniel P. Emrich; Carl B. Watt, PhD; Hope AB Johnstun; Alexis R. Houser; and lab founder and professor emeritus Robert E. Marc, PhD. The pathoconnectome research was supported by NIH grants RO1 EY015128(BWJ), RO1 EY028927(BWJ), P30 EY014800(Core), T32 EY024234(RLP)], and an Unrestricted Research Grant from Research to Prevent Blindness, New York, NY, to the Department of Ophthalmology & Visual Sciences, University of Utah.

National Science Foundation Grant Extends Connectomics Bryan W. Jones, PhD, has joined one of four interdisciplinary teams receiving more than $50 million in grants over five years as part of the National Science Foundation (NSF) Next Generation Networks for Neuroscience program. A total of 70 researchers representing four countries will investigate aspects of how brains work and interact with their environment.

Collaborating with the laboratory of University of Utah Department of Biology Distinguished Professor Erik Jorgensen, PhD, and a team based at the University of Texas, Austin, Jones will examine the relationship between the weight, or strength, of synapses and their structural components. In the retina, synapses allow for the communication between neurons involved in detecting light and the processing of information associated with vision, such as contrast, color, and movement.

Jones will study how synapses are altered in retinal degenerative disease using transmission electron microscopes to reconstruct and analyze synapses.

“Our second and newest electron microscope, recently gifted by the Lawrence T. & Janet T. Dee Foundation, will be crucial to this effort,” said Jones. “It provides a sensitive camera and another transmission electron microscope that we will need to visualize synapses at multiple angles and to perform the work required for this grant.”

A 2-D pathoconnectome image shows rod bipolar cell dendrites and their synapse locations with rod (red), cone (blue), and indeterminate (yellow) photoreceptors. In a healthy retina, you would expect to see many red and green connections rather than the extensive rewiring pictured here.

WHAT IS A TRANSMISSION ELECTRON MICROSCOPE? The technology uses electrons, or subatomic particles, that carry electricity in solids.

Streaming a beam of electrons through a specimen to create an image, the microscope can magnify an object up to 2 million times.

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 RESEARCH

Reading the Eye

THE LANGUAGE

OF

The new Utah Retinal Reading Center at Moran plays a pivotal role in the development of therapies.

The top row of images shows changes detected in the eye of an early-stage AMD patient with mild visual symptoms. The bottom row shows the same eye four years later when advanced atrophy and tissue loss have caused a blind spot in the patient’s central vision.

In 1792, while teaching at Cambridge University, William Farish forever changed the academic world.

Paid by the number of students he could teach, Farish devised the A to F numeric grading system to measure student progress and ultimately increase class size. His system is now a universal yardstick, understood worldwide.

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At the Moran Eye Center’s new Utah Retinal Reading Center (UREAD), which opened in early 2020, a talented team is developing universal grading systems of its own.

sophisticated image analysis software, UREAD is at the forefront of a rapidly evolving field in which scientists are striving to create a common language in the fight against blindness.

Analyzing thousands of images of the human retina in a process known as “grading,” the team is investigating imaging standards that will allow scientists around the world to monitor the progress of eye diseases and the impact of treatments. Supported by a cadre of human image readers and

“This is the work that ultimately decides key questions such as the right time to administer therapies and what data points we should be looking at to determine how effective those therapies are,” explained UREAD Director Steffen Schmitz-Valckenberg, MD.

MAKING THE GRADE Image graders at UREAD review up to 150 high-resolution image sets of the retina each day, answering unique sets of questions about each based on observations and measurements. They must work independently of each other, looking through up to 200 layers of images that constitute a complete retinal scan.

A majority of the work relates to the leading cause of blindness for adults over age 55: age-related macular degeneration (AMD). Schmitz-Valckenberg is a worldrenowned physician-scientist and AMD expert who has spent years developing universal standards as private companies and public institutions race to develop a cure for this devastating condition.

UREAD is assisting the Sharon Eccles Steele Center for Translational Medicine (SCTM) to begin clinical trials of a new therapy for AMD. The effort is now combing through more than 12,000 patient visit image sets, analyzing factors such as how different layers of the retina degenerate in various stages of AMD. For example, one layer might show the earliest changes in thickness, indicating imminent vision loss, or there may be other features present indicating protective effects against rapid disease progression.

THE BIG PICTURE UREAD stands as the only center of its kind in the Mountain West, and since its opening has grown rapidly to take on a variety of collaborations and projects.

Among them is an international effort to create a new classification system of early atrophy in AMD. Schmitz-Valckenberg and University of Melbourne Professor Robyn Guymer, MBBS, PhD, are coordinating data collection and analysis among six world-leading reading centers, including UREAD. Regardless of the goals of each project, Schmitz-Valckenberg sees the big picture: helping patients. A talented retinal physician and surgeon, Schmitz-Valckenberg stresses UREAD’s enormous potential to aid the development of therapeutics and to improve clinical care. Combining telemedicine with independent assessment of imaging data could improve the quality of care. In the world of clinical trials, he envisions reading centers in different time zones collaborating using common standards to speed up global studies—and new interventions.

Steffen Schmitz-Valckenberg, MD.

Schmitz-Valckenberg points out an unmet need to process increasing amounts of information produced by rapidly advancing retinal imaging technologies. That’s where reading centers and artificial intelligence strategies must come in.

“Reading centers have the infrastructure and resources to develop faster, more efficient ways to process patient information,” he said. “I’m confident reading centers will continue to expand their essential role in ophthalmology.”

LEARN MORE Find more information about UREAD online at uread.org.

19

 RESEARCH

Research Spotlight

Preventing Blinding Disease I

N PREMATURE BABIES

Leah A. Owen, MD, PhD, has received a prestigious career development award.

They are the smallest of patients—premature infants at risk of developing a potentially blinding eye disease called retinopathy of prematurity (ROP). While research on this leading cause of childhood blindness has often focused on treatments, Moran Eye Center pediatric surgeon-scientist Leah A. Owen, MD, PhD, is exploring how ROP might be prevented.

In 2020, Owen received a National Institutes of Health Mentored Clinical Scientist Research Career Development Award, a three-year, $500,000 grant that will boost her work. Owen’s lab is exploring how preeclampsia, a dangerous pregnancy complication, may protect preterm infants from developing ROP. She will investigate molecular and genetic factors in the mother, infant, and placenta, which contribute to this ROP protection.

“If we can learn how these babies are naturally ‘protected’ from ROP, then we can develop interventions to prevent rather than mitigate ROP,” Owen said.

As part of the award, Owen will work closely with three international experts:

Leah A. Owen, MD, PhD.

 Kathleen B. Digre, MD, Distinguished Professor of Neurology and Ophthalmology at Moran and an adjunct professor of Obstetrics and Gynecology who also serves as director for the Center of Excellence in Women’s Health at the University of Utah.  Michael W. Varner, MD, H.A. and Edna Benning Endowed Presidential Professor and vice-chair for research for the U’s Department of Obstetrics and Gynecology.  Margaret M. DeAngelis, PhD, Ira G. Ross and Elizabeth Olmsted Ross Endowed Chair at the Ira G. Ross Eye Institute in Buffalo, New York, and an adjunct professor of Ophthalmology and Visual Sciences at Moran.

Owen will also collaborate with a separate team representing expertise in each aspect of the project.

In ROP, abnormal blood vessels grow between the retina and the front of the eye, preventing a sufficient blood supply to the baby’s developing eyes. This can cause vision loss in even mild cases, and complete blindness in the worst.

“ROP is uniquely suited to prevention,” said Owen. “It is not present at the time of preterm birth, but instead develops four to eight weeks later. We want to change that.”

20

Research Spotlight

SHEDDING

New Light Color Vision ON HUMAN

The National Institutes of Health awarded Frans Vinberg, PhD, his first major federal Research Project Grant.

There are millions of them in our eye’s retina—special photoreceptor cells known as rods and cones that allow us to perceive a wide range of light intensities and colors.

Backed by a new five-year, $2 million National Eye Institute Research Project Grant, the lab of Moran’s Frans Vinberg, PhD, is seeking a deeper understanding of photoreceptors and how major blinding diseases, including age-related macular degeneration (AMD) and diabetic retinopathy, affect them.

“There is a critical need to better understand the biology of the photoreceptors in the human retina and macula in health and disease,” said Vinberg, who joined the Moran Eye Center in 2017. “This is particularly true of cone photoreceptors, compared to rods that have been more extensively studied.”

Cones are concentrated in the macula, the small but significant area in the center of the light-sensitive retina. Cones give us color vision and help us see fine details.

Frans Vinberg, PhD. Rods, which aid good vision in low light, concentrate in the outer areas of the retina and give us peripheral vision. The human retina has about 100 million rods and 5 million cones.

Vinberg’s research is unique because it will rely on donated human tissue accessed via collaborations with U.S. eye banks and organ donor societies.

Important past research into light and dark adaptation in the retina has used animal models lacking a macula.

“Very little is known about photoreceptor mechanisms in the human macula,” he continued. “The long-term goals of our project will seek to change this.

We want to generate new knowledge about healthy eyes and explore macular dystrophies to identify potential targets for new therapies that could improve vision or prevent vision loss in aging or diseased human eyes.”

In related research, Vinberg’s lab in 2020 collaborated in a groundbreaking study related to photoreceptors that provided insight on how people with retinal degenerative disease can maintain their night vision for a relatively long period.

Read the study at pubmed.ncbi.nlm.nih. gov/32960171/.

21

 PAT IE N T C A R E

The Rise of Teleophthalmology As the pandemic prompted new concerns for doctors and their patients, Moran’s ophthalmologists found ways to adapt.

Few medical exams require patients and doctors to sit face-to-face, inches apart, for a period of time. But it’s an everyday scenario when it comes to ophthalmology.

The COVID-19 pandemic, necessitating physical distancing and personal protective equipment, required Moran Eye Center physicians and their colleagues across the country to innovate and accelerate the use of telehealth.

Before 2020, teleophthalmology visits were mainly used for connecting eye centers with rural communities or in areas around the world, allowing specialists to help local physicians assess a patient’s condition.

2 1 6 5 4 8 7

While the technology doesn’t lend itself to such things as examining peripheral vision or checking eye pressure, it

22

has proven effective for specialties diagnosing apparent conditions such as droopy eyelids.

At Moran, telehealth efforts have taken various forms depending on circumstance.

ADAPTING TO TELEOPHTHALMOLOGY Kathleen B. Digre, MD, is a nationally renowned specialist in neuroophthalmology. In her words, she’s also “of a certain age.” So when COVID-19 changed the landscape of health care in March 2020, she had to pivot, almost overnight, to keep up with patients’ needs while keeping herself and her patients safe.

“My family was worried about exposure—to the point where they suggested I retire rather than keep working. I got it, but I have too much more to do,” she said. “I’ve adapted.”

15.0%

10.0%

5.0%

Nov–21

Oct–31

Oct–1

Sep–19

Aug–29

Aug–08

Jun–18

Jun–06

May–16

Apr–25

Apr–04

Mar–14

Feb–22

Feb–01

Jan–11

0.0%

TELEHEALTH TREND When pandemic restrictions in March 2020 temporarily halted in-person visits except for urgent conditions, Moran ramped up telehealth services for patients. At the height of the shutdown, video and telephone appointments represented 15% of clinical visits, more than 100 visits per week. Now, 50% of Moran providers offer telehealth options.

Kathleen B. Digre, MD, performs a video call with a patient from her office.

From her office at Moran, she monitors an iPad while fellows and residents mask up and evaluate patients in the clinic. They then present their findings to Digre—often accompanied by visual test results—via a secured video call. If she needs to examine eye movements or pupils or evaluate visual field tests or photos, she can do so virtually.

As much as the system is working, Digre admits she would much rather be in the room with her patients.

“There have been and will be times when I do absolutely need to see a patient in person,” she said. “In that case, I put on full protective gear with a mask and face shield.”

THE PATIENT EXPERIENCE Linda Bliss is retired and divides her time between Arizona and Wisconsin. For the past five years, she has experienced periodic episodes of light sensitivity and the sensation of “seeing a square box” in the middle of her vision. She consulted with several clinics in both of her home states but couldn’t find a doctor who understood her symptoms. Taking her search online, she found a video of Digre describing her exact symptoms and called Moran right away.

Bliss said she felt “completely comfortable” with a virtual visit.

“She sent me an eye exam sheet in advance,” explained Bliss. “Then, when we were online, she had me do some eye movements, asked some questions, and told me exactly what

was going on. It turns out what I was experiencing was an aura called a ‘cortical spreading depression,’ sort of like having a migraine, but without the headache. My experience with Dr. Digre was every bit as good as meeting her in person.”

OCULOPLASTIC CONSULTS THRIVING Although virtual consultations were new for Douglas P. Marx, MD, Moran’s division chief of oculoplastic and reconstructive surgery quickly embraced them.

“As soon as things shut down in March, I felt vulnerable because I knew so many of my patients were vulnerable,” said Marx. “The need was huge, and I didn’t want to leave anyone without help.”

Because almost everything Marx treats—from tear duct infections to orbital fractures and other traumas—starts with an external, visual assessment, he used virtual visits with ease, relying on them as an excellent screening tool. Marx was then able to view scans remotely to form treatment plans.

“We kept a lot of people from coming to a place where they could possibly be exposed to other people and found that most of the time they didn’t need an in-person visit,” said Marx. “The patient satisfaction level for these visits ranks consistently high.

I think it’s the future of medicine. I’m still doing a couple of telehealth visits a day.”

23

 PAT IE N T C A R E

When the World Paused, Moran Didn’t Amid the pandemic shutdown, Moran physicians found safe ways to continue providing urgent care and understanding for patients in danger of losing sight.

Every four weeks for the past decade, 80-year-old Kay Lipman has traveled from her home in Ogden to the Moran Eye Center’s University of Utah campus location to receive sight-preserving injections for her age-related macular degeneration (AMD).

When the COVID-19 pandemic hit, Lipman worried about her health. She was at a higher risk for COVID-19 due to her age, but she also knew AMD could rapidly blind her if left unchecked. Would her treatments be interrupted? If not, what types of safety precautions would the clinic be taking?

Her questions echoed those of millions of people nationwide facing progressive vision loss due to AMD, diabetic retinopathy, glaucoma, and other conditions requiring ongoing treatments but concerned about potential virus exposure. While the pandemic temporarily halted routine exams and surgeries, Moran Eye Center physicians let patients like Lipman know they were ready to continue providing essential, urgent treatments—with extra safety precautions.

“By restricting the number of patients and staff in the building at one time and by screening everyone for symptoms of COVID-19, including taking staff and patient temperatures, we were able to provide uninterrupted care for these patients and meet urgent eye care needs,” said Norm Zabriskie, MD, Moran’s director of clinical operations.

Lanny McLean, of Sun Valley, Idaho, continued driving to Moran every six to eight weeks in 2020 during the pandemic for critical treatment for his age-related macular degeneration.

24

The Moran Eye Center enacted immediate patient safety measures when COVID-19 emerged as a pandemic.

Those included:  Temperature checks and screening questions at entrances.  Mask requirement for everyone in the building.  Physical distancing in waiting rooms and lobby areas.  Hand sanitizer and masks available for patients.  Limited visitor policy.  Enhanced cleaning procedures for exam rooms and common areas.

SIGHT-SAVING TREATMENTS IN AN UNCERTAIN TIME

GOING THE DISTANCE FOR TREATMENT

As much as he relies on his regular treatments, McLean had reservations.

The most common cause of vision loss in people over 55, AMD can take away central vision and the ability to see color and fine detail when looking directly at an object. Researchers have yet to find a cure, but treatments to slow the progression of vision loss have helped Lipman maintain as much precious vision as possible.

Lanny McLean, 86, drives five hours from his Sun Valley, Idaho, home to Moran’s University location every six to eight weeks to see Mary Elizabeth Hartnett, MD.

“As far as the COVID-19 precautions, I was extremely concerned about going to Salt Lake and getting a hotel room. I live in Blaine County, one of the country’s hot spots,” said McLean. “But everything worked out. My experience was perfect—people were masked, it was all properly done. As for Dr. Hartnett, if you ask me, on a scale of one to 10, she is a 20. I am convinced she has saved my eyesight.”

During the COVID-19 pandemic, she and her specialist, Paul S. Bernstein, MD, PhD, remained on track.

“Lanny has bilateral AMD and needs injections in both eyes. Right now, his central vision in one eye is poor, but to preserve vision in both eyes, it is important for him to come in for imaging and regular injections,” said Hartnett.

“I’ve been giving Kay monthly injections in both eyes for AMD for more than ten years,” said Bernstein. “If she were to go too long between visits, her vision would deteriorate. Recently, she has also been receiving chemotherapy at the Huntsman Cancer Institute, so we now have very narrow windows when we can safely give her injections. We are fortunate to be still able to provide timely injections to preserve her visual acuity.”

Lipman’s first treatment during the COVID-19 crisis reassured her safety concerns.

“At the reception desk, they took my temperature, asked me some questions, and then I was the only person in the waiting room,” said Lipman. “It felt very safe.”

Moran retinal specialists, including Paul S. Bernstein, MD, PhD, continued urgent eye care during the COVID-19 pandemic.

25

 PAT IE N T C A R E

Understanding and Help

COVID-19 Physical Distancing Challenges for People with Vision Loss.

Long lines curving around buildings, markers every six feet, one-way arrows painted on floors. These and other safety steps have become part of everyday life during the COVID-19 pandemic.

While intended to keep us safe, such measures are designed for people who can see them.

Darran Zenger, MSW, is not one of those people. Zenger has Usher syndrome and describes his vision as “like looking through two straws, each smeared with Vaseline on the end.”

P le a s use theisdo not se at

Pleas use theisdo not seat

He expertly navigates the world with the help of a white cane and his guide dog, Lou. He cooks, uses a smartphone, takes public transportation, and considers himself adaptable to just about any situation.

But physical distancing has presented challenges never imagined by Zenger and others with visual impairments that cannot be corrected with standard eyeglasses, contact lenses, medication, or surgery.

“Social distancing obviously presents a radically different world for people with visual impairments,” explains Lisa Ord, PhD, LCSW, director of the Moran Eye Center Patient Support Program.

“Heightened tensions brought on by fear of the coronavirus make it more important than ever to be aware not everyone can see physical barriers or read signs,” Ord says. “And public spaces with blocked-off chairs are confusing to guide dogs who may be getting mixed signals—their owners might say one thing, but the barrier prevents the guide dog from moving.”

PLEASE WAIT HERE

O NE WAY SYSTEM

SOCIAL D

IS

TA N C I N G

THE INVISIBLE BARRIERS OF THE CORONAVIRUS CRISIS

PLEA

For Zenger, everyday shopping can be especially fraught with frustration.

VISION LOSS COMBINED WITH HEARING LOSS Rob Morrow has limited vision in some environments and no vision in bright sunlight. He is also profoundly deaf, and though a cochlear implant helps, he sometimes has trouble understanding words.

“My first outing after the coronavirus struck was to a busy Starbucks,” he says. “At the time, I was completely unaware of the required social distancing. I normally have a difficult time standing in line because it’s hard to determine where others might be in relation to me. I ended up getting too close to someone, and he yelled at me. Because of all the background noise, I couldn’t understand what he was saying, so I moved closer, and then he got louder and actually pushed me away. I finally understood what he was saying, but I was so embarrassed I left.”

Morrow shops alone and has encountered many challenges, from maintaining distance to navigating the invisible barriers.

SE

“I shop with a sighted person,” he says. “I also take my white cane, so it’s a signal that I may not be able to tell exactly what’s in front of me. My friend can tell me where the six-foot markers are, but what’s hardest for me are the transparent barriers between the checkers and myself.”

ST

AND HERE

ABOUT MORAN’S PATIENT SUPPORT PROGRAM Moran’s Patient Support Program offers a variety of professionally moderated support groups and vision rehabilitation services to help patients of all ages, together with their families and caregivers, find ways to understand, accept, and move past the limitations of vision loss. Visit healthcare. utah.edu/moran/vision-loss-supportprogram/ for information.

“It’s taken me weeks and several hard experiences to figure it out,” he says. “My anxiety level increases before I even venture out.”

HOW YOU CAN HELP

Tips from Moran Patient Support Program Director Lisa Ord, PhD, LCSW: · If someone with a white cane or a guide dog seems to be confused or struggling, please

don’t touch that person. Just speak up and ask if you can help.

· Describe the surroundings. If you’re waiting in a line, you can tell the person when the

line is moving and verbally guide them to the next marker.

· Describe any barriers—what and where they are—with as much precision as possible.

For instance, instead of “over there, to your left,” say “two feet to your left.”

· If the person is looking for an empty chair in a waiting area, tell them where it is. · Are there written signs? Let the person know and read the sign to them. · Remember that masks muffle voices, so speak clearly and slowly, but don’t raise your

voice unless necessary because of background noise.

· If you’re getting on an elevator and there’s a passenger limit, let the person know how

many people are allowed and if it’s OK to enter.

27

A Legacy of Giving

Dr. E.R. and Edna Wattis Dumke.

DR. EZEKIEL R. AND EDNA WATTIS DUMKE FOUNDATION The Dr. Ezekiel R. and Edna Wattis Dumke Foundation has given a transformative $1 million gift to support sight-saving outreach work in Utah and around the world by creating the Moran Eye Center Global Outreach Division’s first endowed directorship.

For decades, humanitarian work has been integral to the Moran Eye Center, which has a culture of connecting its physicians and staff, working on a volunteer basis, with those in need.

“This generous gift comes at a critical time,” said Randall J Olson, MD, Moran CEO and chair of the Department of Ophthalmology and Visual Sciences at the University of Utah. “It makes it possible for us to recruit an outstanding, visionary leader to guide our team as we work to expand the program and to meet increasing needs in Utah. The Dumke 28

family has always been there for us, and we could not be more grateful for their support and confidence in our program.”

Funded solely by donors, the outreach team partners with governments, academic institutions, and physicians in the developing world to create low-cost, high-volume ophthalmic surgical centers of excellence. In addition to conducting sight-restoring surgeries and ophthalmic training abroad, Moran’s outreach work is making a significant and growing impact in Utah.

In the greater Salt Lake area, Moran physicians and staff provide eye screenings and glasses regularly to the refugee, homeless, and uninsured populations.

They perform much-needed charity surgeries throughout the year, making it possible for patients to continue to work and care for their families.

In partnership with the Utah Navajo Health System, the outreach team has visited the Navajo Nation more than 40 times over the past five years to provide eye surgeries, vision screenings, and eyeglasses.

A LONG HISTORY OF SUPPORT The ability to see the need and make a difference by supporting health care and humanitarian causes in Utah runs long and deep in the Dumke family, starting with the philanthropy of Dr. E.R. and Edna Wattis Dumke in the 1950s. Their philanthropic work, carried on by their children and grandchildren today, has left its mark on countless lives and institutions.

Moran’s new endowed directorship came as part of a major donation by the Dr. Ezekiel R. and Edna Wattis Dumke Foundation to University of Utah

Health. It included $5 million to support Health Sciences’ Simulation and Experiential Learning and $500,000 for the School of Medicine’s Rural and Underserved Utah Training Experience.

The philanthropic relationship with Olson began in 2003 when Zeke Dumke Jr. realized that the rapidly growing Moran Eye Center needed a larger building. He made a gift of $100,000 so Olson could hire a surveyor and get started on what would become Moran’s current, 210,000-square-foot home. The architecturally stunning center opened in 2006 with two pavilions—one to provide clinical and surgical care, and the other to house Moran’s world-class research labs.

Martha Ann “Markey” Dumke Healy, Zeke’s sister, was also a major investor in the new building. She joined with younger brother Ed Dumke to name Moran’s clinical and surgical care wing the Dr. E.R. & Edna Wattis Dumke Clinical Pavilion.

Now, after 40 years of serving as foundation board members and continued giving to the health care and arts communities, Claire Dumke Ryberg, Nancy Healy Schwanfelder, and Andrea Dumke Manship are in the process of sunsetting the foundation in hopes of creating a lasting legacy.

“This final gift strengthens the legacy of Edna and Zeke and is a tribute to the longstanding relationship between Markey, Zeke Jr., Ed, and the Moran Eye Center,” said Olson. “We will make the most of it, honoring the Dumke name as we grow our outreach programs in Utah and around the world.”

Dr. E.R. and Edna Wattis Dumke with children, from left, Martha Ann, Zeke Jr., and Ed.

29

 OUTREACH

“We continue to assist members of our local community during the pandemic safely. We have precautions, protocols, and testing in place for ongoing outreach. The need for eyesight that allows people to keep their jobs, care for family members, and participate in the community is still there. We will be, too.”

—Jeff Pettey, MD, MBA, outreach division co-medical director

There for Utah While the COVID-19 pandemic temporarily halted the Moran Eye Center Global Outreach team’s international travel for 2020, physicians and volunteers continued their local outreach work, providing much-needed eye care to nearly 200 patients in addition to triaging dozens more in line to receive treatment.

Manuela Lechuga was one of those patients. A cloudy haze caused by a cataract was stealing her vision, preventing her from driving or cooking safely. Those difficulties presented formidable barriers to the 55-year-old. But she was thinking mainly of her daughter when she lamented her failing eyesight.

Lechuga serves as the primary caregiver for the 32-year-old woman, who has cerebral palsy and requires a physically intense care level.

But Lechuga couldn’t afford the out-of-pocket costs associated with cataract surgery. Without insurance, money was simply too tight.

Thanks to Moran’s Operation Sight Day in October 2020, she was able to undergo donor-funded surgery to restore her vision and her ability to care for her daughter.

Manuela Lechuga, below left, following her 2020 Operation Sight Day cataract surgery, and with her daughter.

30

Similar scenarios played out statewide, as volunteer physicians, staff, nurses, and technicians served patients from local free clinics to the Navajo Nation.

Operation Sight Day October 2020 Consuelo Mejia’s granddaughter escorted her to Operation Sight Day. The 87-year-old mother of nine and beloved grandmother was anxious to get back to her role in the family, knitting and cooking.

After her sight was restored, she said she felt like she had her “power” again.

Teddy Bear Clinic August 2020

The Moran outreach team pre-screened 420 children, conducted 20 exams, and made eyeglasses for eight children during the Teddy Bear Clinic. Utah Navajo Health System (UNHS) hosted the event in Blanding.

Pediatric specialist Robert Hoffman, MD, asked questions during the drive-through Teddy Bear Clinic to determine whether children were experiencing vision issues. If so, he gave them a thorough eye exam in the clinic.

Katherine Hu, MD, examines a child during the Teddy Bear Clinic.

31

 OUTREACH

Thinking Globally, Acting Locally Moran is partnering with local service organizations to identify eye care needs in underserved populations across the state.

The Moran Eye Center’s Global Outreach Division provides care to thousands of Utahns in need each year thanks to donors who provide funding for free or low-cost eye exams, surgeries, and eyeglasses at clinics around the state and on the Navajo Nation.

NEEDS ASSESSMENT NEXT STEPS The group is reviewing available data and conducting surveys and interviews to document local resources and service gaps. After interpreting the results, the team will set an agenda. Ideally, the plan will enable partners throughout the state to provide basic eye care and refer complex cases to Moran.

From left: Craig Chaya, MD; Sean Collon, MD; and Sharon Talboys, PhD, MPH.

32

This outreach work to preserve or restore eyesight strengthens local communities as those who receive care can find or hold jobs, read, drive, look after children, and engage in school. Yet the need for eye care in Utah and worldwide rapidly outpaces capacity and available resources.

A newly launched Community Eye Health Assessment aims to identify how current efforts can expand or improve to keep pace with changing needs. In partnership with the University of Utah’s Division of Public Health, the Moran Outreach Division is taking an innovative, detailed look at the health care needs of four of Utah’s underserved communities: Native Americans, those experiencing homelessness, resettled refugees, and the underinsured or uninsured.

“It has become apparent to us that we don’t have a clear picture of the visual health needs in our state,” said Global Outreach Division Co-Medical Director Craig Chaya, MD. “We need to understand the many factors, such as social determinants, that may affect eye health. This has led us to take a more comprehensive, scientific approach to understanding the multitude of issues our communities face.”

Moran resident Sean Collon, MD, proposed the idea of a local outreach assessment, which is expected to take 18 months to complete.

THE GOAL: EXPANDING LOCAL OUTREACH The needs assessment will provide a road map to expand local outreach initiatives. In a typical year, those efforts include:

      NORTHERN UTAH CLINICS

220 sight-restoring surgeries 1,200 eye exams 1,100 free pairs of eyeglasses 500 volunteers perform 25,000 service hours Northern Utah partnerships include three

community clinics in Salt Lake County and Park City, and regularly scheduled care at Moran’s

main campus and two satellite locations.

A partnership with the Utah Navajo Health System includes outreach events at several community health centers and schools.

Reaching Out to Community Partners Chaya and Division of Public Health Assistant Professor Sharon Talboys, PhD, MPH, hosted a virtual stakeholder kickoff event in September 2020. They explained their approach, learned more about myriad community providers, established new partnerships, and asked, “Who else needs to be at the table?”

More than 45 participants chimed in.

“Involving local stakeholders, such as Friends for Sight, the Urban Indian Center of Salt Lake, Volunteers of America, The Hope Alliance, numerous remote medical clinics, as well as talking to the populations we serve, will help us assess strengths already out there in the community, along with quantifying the needs,” said Talboys.

Added Collon: “The goal is to better understand the problems that the most vulnerable and underserved individuals are facing with regards to eye health, and then to use that knowledge to mount an organized and unified response.”

UTAH NAVAJO HEALTH SYSTEM CLINICS

33

 OUTREACH

Growing Problem OF Worldwide Blindness CONFRONTING THE

Researchers, including Moran’s Mary Elizabeth Hartnett, MD, are identifying the scope of the challenge and looking for solutions.

Sobering statistics released by the Global Burden of Disease study in 2020 found no significant reduction in the number of people with treatable sight loss worldwide since 2010 as public health services failed to meet World Health Organization (WHO) targets.

director of Women’s Eye Health, said the information paints a clearer picture of where efforts should be focused.

“We have made some strides in reducing blindness, but we really have work to do to address moderate to severe vision impairment,” said Hartnett. “It’s crucial that we fund research to focus efforts on improving outcomes and to examine the unequal burden of blindness for women, including the root causes for disparity, the potential barriers to accessing care, and potential biologic differences. Additional data on childhood blindness is also needed.”

Two studies examined rates of blindness and vision impairment worldwide in light of WHO goals to achieve a 25 percent reduction in avoidable sight loss in the decade leading up to 2020. Efforts fell short, failing to keep pace with population aging and growth. That puts global blindness and severe vision impairment on track to double by 2050.

With population growth estimated to be greatest in countries designated as least developed, many in sub-Saharan Africa, it’s important to train more eye doctors in these areas and to increase access to low-cost eyeglasses, said Hartnett.

Cataracts were the leading cause of blindness worldwide, accounting for 15 million people or around 45% of global blindness. Diabetic retinopathy was the only cause of blindness to show a global increase in age-standardized prevalence between 1990 and 2020, according to the research, and the global prevalence of nearly every major cause of blindness and vision loss is higher in women than men.

The study underscores the need for continued gender disparity research and two Moran Eye Center programs: the Global Outreach Division and Patient Support Program. The outreach team works to create sustainable eye care systems in lowresource nations and reach underserved populations in Utah.

The Patient Support Program offers professionally moderated support groups and vision rehabilitation services.

Moran Eye Center surgeon-scientist Mary Elizabeth Hartnett, MD, an author on the research who serves as a co-chair for the Presidential Commission on the Status of Women and

By 2050, researchers estimate the numbers of blind and visually impaired at:

50%

61 million blind 474 million with moderate and severe vision impairment



360 million with mild vision impairment



866 million with uncorrected presbyopia, or farsightedness due to age

40% P R E VA L E NCE

 

Prevalence of Blindness and Moderate and Severe Vision Impairment (MSVI)

30%

Blind <20/400 MSVI <20/63 20/400 presenting vision in the better eye

20% 10% 0%

0

10

30

40

50

60

70

80

90

AGE

Source: Vision Loss Expert Group

32

20

MSVI, male

MSVI, female

Blind, male

Blind, female

 E DUC AT ION

Connecting Fellows TO ADVANCE Global Ophthalmology In 2020, the Moran Eye Center co-hosted the first Global Ophthalmology Symposium to bring together fellowship trainees from across the nation.

One of the few academic eye centers in the U.S. to have a dedicated outreach division, the Moran Eye Center established the nation’s first global ophthalmology fellowship.

Now, six more programs offer a fellowship, and in 2020 Moran co-hosted the first annual Global Ophthalmology Symposium with Emory University. The virtual event created discussions and collaborations designed to push the field forward and strengthen an international mission of sustainable eye care. The symposium covered topics including the global burden of blindness, public eye health campaigns, cultural competence, ethics, and tackling medical and surgical approaches that differ in low-resource settings.

“The event was exciting,” said Ashlie Bernhisel, MD, Moran’s current global fellow. “We exchanged knowledge and experience and established a sense of camaraderie. That was especially welcome during the unique circumstances of the coronavirus pandemic.”

Fellows continue to connect digitally for journal clubs, guest speakers, and domestic outreach collaborations.

“Global ophthalmology is a burgeoning field with new fellowships coming online throughout the country,” said Moran Vice Chair for Education Jeff Pettey, MD, MBA. “As more academic departments establish fellowships, Moran’s experience allows for rich collaboration on topics such as public health, healthcare disparities, and unique surgical procedures used in global ophthalmology settings.”

Fellowships provide opportunities to deepen compassion and become a better physician, said Pettey. “We pride ourselves in allowing Moran global fellows to lead projects in their unique areas of interest and expertise.”

Bernhisel recently completed a master’s degree in Public Health in Eye Care. Currently, she is researching telehealth and participating in a major community eye care needs assessment at Moran.

Past Moran fellows have taken on projects including initiating glaucoma training for ophthalmologists in Tanzania; developing an open-access, interactive online ophthalmic curriculum for nurse training in Ghana; and coordinating efforts to produce critical personal protective equipment for outreach partners in Haiti, Tanzania, Ghana, and Nepal.

Ashlie Bernhisel, MD, Moran’s current global fellow, performs outreach care during a pre-2020 international trip.

MAKING CONNECTIONS

Seven U.S. institutions offer global fellowships and participated in the symposium:

      

Emory University University of Illinois-Chicago Thomas Jefferson University University of Michigan University of Oklahoma Stanford University University of Utah

35 33

Residents and Fellows

MOR A N E Y E CE N T E R

2 0 2 0 -2 0 2 1

Moran offers one of the nation’s top educational programs, providing excellent didactic training and extensive surgical experience. The latest Ophthalmology Times survey of chairpersons and residency program directors at eye centers across the country ranked Moran No. 9 in the nation for Best Residency Program. A 2020 survey by physician website Doximity placed Moran’s residency program at No. 9 in the country and No. 2 in the West.

A Unique Approach

Our residents leave the program exceptionally prepared for their next steps. Interns complete a combined ophthalmology and internal medicine program. They spend three months in ophthalmology, including one half-day a week at Moran’s Continuity Clinic, where they follow a patient’s care throughout their ophthalmology rotation. Interns may use additional elective time to improve their preparation for ophthalmology training.

Moran goes beyond the traditional model to teach residents and fellows how to provide patients with the best outcomes at the lowest cost. Residents and faculty recently collaborated to build a dynamic, interactive ophthalmology curriculum and launched a wellness program that includes protected academic time.

F E L L OW S HIP P R O G R A M 2 0 2 0 -2 0 2 1 RETINA

Hong-Gam Le, MD Nikko Ronquillo, MD, PhD

GLAUCOMA

Austin Nakatsuka, William W. MD Stoddard, MD

CORNEA

Brett M. Gudgel, MD

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Eric Weinlander, MD

R E S ID E N C Y P R O G R A M 2 0 2 0 -2 0 2 1 FIRST YEAR

UVEITIS

Joseph Simonett, MD

Wen Fan Hu, MD, PhD

Sean Collon, MD

SECOND YEAR

NEURO-OPHTHALMOLOGY

Amanda J. Redfern, MD

Srav Vegunta, MD

Katherine Hu, MD Marshall Huang, MD

Ariana Levin, MD

Michael Murri, MD

T H I R D Y E A R /C H I E F R E S I D E N T S

GLOBAL

Ashlie A. Bernhisel, MD

Abigail Jebaraj, MD Allie Simpson, MD Cole Swiston, MD

Christopher Bair, MD

Bradley Jacobsen, Theresa Long, MD MD

Rachel Patel, MD

MOR A N E Y E CE N T E R

Residents and Fellows

2 0 2 0 -2 0 2 1

IN T E R N S & O P H T H A L MI C PAT H O L O GY/R E S E A R C H F E L L OW S

INTERNS

Program Growth

The program continues to be in high demand, with 504 resident applications for four spots in 2020. Including interns, Moran trains 16 residents and 11 fellows in specialties like cornea and refractive surgery, glaucoma, neuro-ophthalmology, retina and vitreous surgery, uveitis, and global outreach.

High Surgical Volumes

Tyler Etheridge, MD

Brandon Kennedy, MD

Clinical faculty members perform more than 7,000 surgeries per year and see about 140,000 patients, ensuring residents and fellows have a full range of clinical and surgical experiences. In three years, one Moran resident, on average, performs about 740 surgeries and procedures. More than 300 are cataract surgeries—86 is the national requirement; 197 the national average. Board-certified attending faculty supervise all surgeries and procedures. A wet lab and surgical simulator give residents additional opportunities for hands-on experience.

Dedicated Research Time

Moran residents may receive up to one-half day of dedicated research time per week for projects during their training. We also provide funding opportunities such as the Achievement Rewards for College Scientists (ARCS) Foundation’s scholars program. Each year, at least one resident is awarded $15,000, and Moran matches funds for his or her second and third year.

Anthony Mai, MD

Lydia Sauer, MD

O C U L A R PAT H O L O G Y/ R E S E A R C H

Outreach Opportunities

Moran residents complete four-week international rotations during training, and many fellows travel with faculty to a number of countries in partnership with Moran’s Global Outreach Division.

Griffin Jardine, MD, Moran’s director of wellness, meets in early 2020 with resident Ariana Levin, MD, through the Mocha with a Mentor program.

Catherine Culp, MD

Phillip Qu, MD

MOCHA WITH A MENTOR Created by residents as part of a new medical student wellness initiative, Moran’s Mocha with a Mentor program bypasses formal pairing of mentors and residents. It instead empowers residents to seek out a faculty member they admire.

The team sends an email invitation on behalf of residents to faculty, indicating that a resident would like to meet and treat the faculty member (with a

department-issued $10 gift card) for oneon-one time. Residents can ask mentors about their careers, research, and ophthalmology in general—or anything else on their minds.

“It’s been a hit,” said Griffin Jardine, MD, Moran’s director of wellness. “Faculty are flattered, residents get their undivided attention, and it goes a long way in terms of making meaningful connections.”

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 E DUC AT ION

Supporting Student Physician-Scientists

Each year, the Achievement Rewards for College Scientists (ARCS) Foundation awards $15,000 to an incoming Moran Eye Center resident to support research.

This generous gift allows promising young scientists to pursue research during their residencies with the hope they will choose careers that continue their scientific investigations. Moran matches the award for the following two years of residency, providing a total of $45,000.

Moran’s 2020 ARCS Scholar, Lydia Sauer, MD, is an accomplished researcher who has already contributed to medical advances using new imaging technology to detect eye diseases earlier than ever before.

Sauer completed medical school at Friedrich Schiller University in Jena, Germany, where she also pursued a doctoral degree in the Department of Experimental Ophthalmology.

Her thesis focused on a new retinal imaging technology—fluorescence lifetime imaging ophthalmoscopy

Lydia Sauer, MD, left, performs a scan using fluorescence lifetime imaging ophthalmoscopy (FLIO).

(FLIO). She received a prestigious award for her work from the German Ophthalmological Society.

Sauer’s research in FLIO related to retinal carotenoids, which serve as antioxidants, connected her with Moran’s Paul S. Bernstein, MD, PhD. She accepted a visiting scholar position, helping establish Moran as the first FLIO imaging and research center in the U.S. From 2018 until 2020, Sauer worked as a postdoctoral researcher in Bernstein’s

HEED FELLOW AWARD

Uveitis fellow Wen Fan Hu, MD, PhD, is a 2020-2021 Heed Fellow awardee.

Hu completed her residency at Massachusetts Eye and Ear, and received her medical and doctorate degrees from Harvard University.

The Heed Ophthalmic Foundation gives about 20 awards yearly to talented young ophthalmologists pursuing postgraduate fellowship training. Each recipient receives a merit award of $10,000.

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lab, helping publish numerous FLIO studies that could revolutionize how clinicians diagnose diseases. She received the Heidelberg Engineering Xtreme Research Award in 2019.

As a resident, Sauer aims to continue establishing FLIO as a clinical diagnostic tool.

She is proud to receive the ARCS Foundation’s Mark and Kathie Miller Award, which was established in honor of Moran CEO Randall J Olson, MD.

INTERNATIONAL RESEARCH PRIZE Resident Bradley Jacobsen, MD, Moran’s 2017 ARCS Scholar, received a prize from the European Society of Retina Specialists (EURETINA) for research into retinal diseases in Africa.

Jacobsen’s presentation, “Characterization of ‘AMD-like’ phenotypes in two African populations from Tanzania and Ghana,” placed second for Best Free Papers as part of EURETINA 2020.

Awards& Honors

HIGHLIGHTS

NATIONAL RANKINGS

U.S. News & World Report ranked the Moran Eye Center No. 13 in the nation for providing excellent patient care.

The ranking, published as part of the magazine’s annual Best Hospitals for Ophthalmology report, is based on voting results asking ophthalmologists across the nation where they would send patients with the most complex eye conditions.

“I’m delighted our peers across the country realize the exceptional care the Moran Eye Center offers,” said Moran CEO Randall J Olson, MD. “Among patients, the Moran Eye Center may be one of the best-kept eye care secrets in the country, so I couldn’t be more pleased the word is out with this new ranking.”

In the annual Ophthalmology Times survey of chairpersons and residency program directors nationwide, the Moran Eye Center ranked among the top 12 programs in the nation in clinical care, research, and education.

THE LATEST OPHTHALMOLOGY TIMES RANKINGS:

 

No. 11 in the nation for Best Overall Program.

No. 12 in the nation for Best Research Program.

Alan S. Crandall, MD.

 

No. 9 in the nation for Best Residency Program.

No. 12 in the nation for Best Clinical Care Program.

Gregory S. Hageman, PhD.

Nick Mamalis, MD.

Randall J Olson, MD.

Liliana Werner, MD, PhD.

2020 POWER LIST

The Ophthalmologist magazine named five Moran faculty members among the most influential figures in ophthalmology internationally, placing them on its 2020 Power List. Those honored on the list: the late Alan S. Crandall, MD; Gregory S. Hageman, PhD; Nick Mamalis, MD; Randall J Olson, MD; and Liliana Werner, MD, PhD. The list celebrates individuals who have significantly impacted the field through ongoing commitments to innovation or philanthropic initiatives.

The Moran Eye Center ranked third-highest of any institution for its number of faculty represented on the list.

Also named to the Power List with ties to the Moran Eye Center:  Sharon Eccles Steele Center for Translational Medicine adjunct research professors Eugene de Juan, MD; and Anat Loewenstein, MD.



Moran adjunct ophthalmologists Iqbal “Ike” Ahmed, MD, FRCSC; John Berdahl, MD; Sanduk Ruit, MD; and Geoff Tabin, MD. 39

Awards& Honors

HIGHLIGHTS

Liliana Werner, MD, PhD, has been named Moran’s inaugural Vice-Chair for Equity, Diversity, and Inclusion (EDI). As a key part of Moran’s senior management team, Werner will lead a range of efforts, including a top goal of increasing diversity in faculty and student ranks.

“When I moved to Salt Lake City to join the Moran Eye Center faculty in 2002, feeling welcomed, appreciated, and respected in my identity as a woman, Latina, and Brazilian immigrant was vitally important to me,” Werner said. “We do not take for granted that all potential candidates and newly recruited faculty, staff, and trainees yearn for the same feeling, especially those from historically excluded communities.”

Werner co-directs the world-renowned Intermountain Ocular Research Center based at Moran, vetting new intraocular lens technology and conducting groundbreaking research on related complications. She lectures worldwide and recently became the new U.S. associate editor of the Journal of Cataract & Refractive Surgery.

As part of her new position, Werner will serve as chair of a Moran committee with faculty, staff, and student representatives to help guide EDI initiatives.

“Our goal is to be the model EDI program for the country with results our only signs of success,” Moran CEO Randall J Olson said in announcing the leadership position.

More about Moran’s EDI committee: healthcare.utah.edu/moran/equity-diversity-inclusion.php.

Kathleen B. Digre, MD, received the 2020 John R. Graham Lecture Award from the American Headache Society (AHS) for her preeminent work as a clinician and educator.

Digre, a neuro-ophthalmology specialist and past president of AHS, will use the $1,000 award to support her eye pain and photophobia research. As part of the award, Digre delivered a lecture during the AHS Annual Scientific Meeting.

A surgical education video produced by a team including the late Alan S. Crandall, MD, and Liliana Werner, MD, PhD, received awards during the American Academy of Ophthalmology (AAO) and American Society of Cataract and Refractive Surgery (ASCRS) virtual meetings in 2020.

The video, “New Pupil Expander Used for Capsular Bag Support,” received Best of Show honors at AAO and was named the winner in the Instruments & Devices/IOLs category at the 38th ASCRS Film Festival.

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Surgical View

Miyake-Apple View

A scene from “New Pupil Expander Used for Capsular Bag Support.”

Awards& Honors

HIGHLIGHTS

Nick Mamalis, MD, received the 2020 Distinguished Alumni Award from the University of Utah School of Medicine Alumni Association for excellence in clinical practice, academic activities, and research accomplishments.

Mamalis, director of the Ophthalmic Pathology Laboratory, is a noted physicianscientist who has led research into virtually every artificial intraocular lens (IOL) on the market at Moran’s Intermountain Ocular Research Center, where he serves as co-director. Among his many professional accomplishments, he is the immediate past president of the 8,000-member American Society of Cataract and Refractive Surgery and editor emeritus of the Journal of Cataract and Refractive Surgery.

Mark D. Mifflin, MD, was named an "unsung hero" by the American Academy of Ophthalmology, which shared stories in 2020 of physicians "quietly serving the underserved, mentoring the next generation and sharing their skills with the world."

"Dr. Mifflin quietly finds time to give back in his own community and overseas as a volunteer," wrote Jeff Pettey, MD, MBA, in nominating his colleague for the honor. "Dr. Mifflin lends his time as a volunteer for underserved Utahns. He has tirelessly worked to establish an eye bank in Bolivia. Dr. Mifflin, his fellows, and other surgical volunteers will continue to return to Bolivia to provide ongoing surgical and eye banking training."

Karen Curtin, PhD, MStat, and Barbara M. Wirostko, MD, FARVO, will serve as co-principal investigators for a two-year project funded by a BrightFocus Foundation National Glaucoma Research award of nearly $180,000. The research project, “Prognostic Factors and Predictive Markers of Progression to Exfoliation Glaucoma in Exfoliation Syndrome,” will include a multidisciplinary university team of experts.

BrightFocus has awarded nearly $35 million since 1978 to support research projects on the causes and potential prevention and treatment of glaucoma.

Curtin is associate director of the Utah Population Database and an adjunct professor of Ophthalmology and Visual Sciences at the Sharon Eccles Steele Center for Translational Medicine.

Wirostko specializes in treating glaucoma patients and researching drug development for glaucoma pharmaceutical therapies.

Barbara M. Wirostko, MD, FARVO.

Karen Curtin, PhD, MStat.

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Awards& Honors

HIGHLIGHTS

James Gilman, CRA, FOPS, contributed the cover photo, at right, for the August 2020 edition of Ophthalmology Retina. Gilman’s image, “Retinal Detachment,” received an Honorable Mention in the Color Fundus Ultra-Wide Angle category at the Ophthalmic Photographers’ Society (OPS) 2019 Scientific Exhibition. His image of lattice dystrophy, above, earned second place for slit lamp photography at the American Academy of Ophthalmology 2020 OPS Scientific Exhibit.

Mary Elizabeth Hartnett, MD, in 2020, took the helm of key initiatives, including women’s eye health education, diversity initiatives, and masking promotions during the pandemic.

As part of the nonprofit Women’s Eye Health organization, Hartnett spearheaded a relaunch of w-e-h.org. Women account for more than two-thirds of the world’s population of blind and visually impaired persons. The group’s website aims to provide the knowledge women need to understand their risk, protect their vision, improve their eyesight, and empower their families.

The site is produced in partnership with the National Eye Health Education Program and Women in Ophthalmology and features content written by women for women.

As co-chair of the Presidential Commission on the Status of Women, Hartnett was asked to serve on the University of Utah’s One U Thriving steering committee, an initiative launched

by Equity, Diversity, and Inclusion Vice President Mary Ann Villarreal. One U Thriving brings together four campus committees to examine policies that perpetuate racism and inequity at the University.

As the pandemic began to spread, Hartnett saw firsthand the critical need for educating younger people about the importance of wearing masks. She spurred the creation of an awareness campaign using videos and social media to help students speak to their peers and educate the community.

Hartnett also served as the 2020 chair-elect of the School of Medicine College Council and has continued as the 2021 chair.

As director of Moran’s Pediatric Retina Center, Hartnett is one of a few pediatric retina specialists trained to diagnose and treat pediatric retina disorders. She created the first-ever academic textbook on the subject, Pediatric Retina, recently released in its third edition, with contributions from experts worldwide. The textbook has proven to be an essential resource for residents and ophthalmologists internationally.

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Ophthalmologists

MOR A N E Y E CE N T E R

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CEO of the John A. Moran Eye Center Randall J Olson, MD, is the Chair of the Department of Ophthalmology and Visual Sciences and CEO of the John

A. Moran Eye Center. He specializes in research dealing with intraocular lens and cataract surgery. Dr. Olson is the author of more than 300 professional publications and has given many named lectures all over the U.S. and worldwide. He was selected to receive the 2016 Jan Worst Medal by the International Intra-Ocular Implant Club, the 2015 Lifetime Achievement Award by AAO, the 2014 Rosenblatt Prize for Excellence by the University of Utah, the 2014 Kelman Award by AAO, the 2012 Binkhorst Medal by ASCRS, and the 2019 Governor’s Medal for Science and Technology. Dr. Olson’s practice is limited to consultations and his long-term patients at this time.

SPECIALTY • Cataract Services and External Eye Diseases

Doctors in alphabetical order

Paul S. Bernstein, MD, PhD,

William Barlow, MD,

is a comprehensive ophthalmologist and ocular surgeon with a specific interest in cataracts, complex cataract surgery, pterygium removal, and refractive eye surgery such as LASIK and PRK. He provides medical and surgical care for these conditions as well as general ophthalmic concerns.

Dr. Barlow is a team ophthalmologist for the Utah Jazz.

is the Val A. and Edith D. Green Presidential Endowed Chair in Ophthalmology and Visual Sciences. He specializes in AMD with special emphasis on the role of nutrition and environment in its treatment and prevention; inherited retinal and macular dystrophies; and surgical treatment of vitreoretinal disorders such as diabetic retinopathy and retinal detachments.

SPECIALTIES • Vitreoretinal Diseases and Surgery • Retinal Biochemistry • Macular and Retinal Degeneration

Craig J. Chaya, MD,

is Co-Medical Director, Moran Global Outreach Division. He specializes in the medical and surgical management of adult and pediatric cataracts, glaucoma, and anterior segment surgery. He is actively involved in Moran’s resident and glaucoma fellow training programs and local and international outreach work. His research interests include the management of cataracts and glaucoma in the developing world and glaucoma surgical techniques and devices.

SPECIALTIES • Cataract Surgery • Glaucoma • Anterior Segment Surgery

Alison Crum, MD,

specializes in both oculoplastics and orbital surgery—the reconstruction of the bones around the eyes after traumas, correcting drooping eyelids, and aesthetic surgeries, such as eyelid lifts. She also practices neuro-ophthalmology and provides medical and surgical treatments for visual disorders. Her interests include treatment of Graves’ disease and papilledema.

SPECIALTIES • Neuro-Ophthalmology • Oculoplastics and Facial Plastic Surgery

SPECIALTIES • Comprehensive Ophthalmology • Cataract Services

James Beson, DO,

specializes in comprehensive ophthalmology with a focus on the medical management of routine and complex glaucoma.

SPECIALTIES • Comprehensive Ophthalmology • Glaucoma

Susan Chortkoff, MD,

focuses on the management and treatment of glaucoma and on comprehensive ophthalmology, and has a special interest in the management of dry eye syndrome.

SPECIALTIES • Comprehensive Ophthalmology • Glaucoma

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Ophthalmologists

MOR A N E Y E CE N T E R

Kathleen B. Digre, MD,

is the Distinguished Professor of Neurology and Ophthalmology.

She is past president of the American Headache Society and the North American Neuro-Ophthalmology Society. She specializes in neuro-ophthalmology and evaluates and treats complex visual complaints. Her clinical research focuses on gender differences in neuro-ophthalmic disorders, pseudotumor cerebri, photophobia, headaches, and eye pain. She has authored over 250 professional publications and five textbooks. She lectures nationally and internationally. She worked with the North American Neuro-Ophthalmology Society and the University of Utah Eccles Health Sciences Library to develop the Neuro-Ophthalmology Virtual Educational Library (NOVEL), novel.utah.edu. She chairs Moran’s Clinical Ophthalmology Resource for Education (CORE), morancore.utah.edu, and library committees. Honors include the Rosenblatt Prize, an honorary degree from the University of Zurich, and a Distinguished Alumna award from the University of Iowa.

SPECIALTY • Neuro-Ophthalmology

David C. Dries, MD,

provides medical and surgical care for eye diseases and visual impairments in children as well as the evaluation and management of strabismus in children and adults. His interests include amblyopia, esotropia, exotropia, retinopathy of prematurity, infant and childhood cataracts, and nasolacrimal duct obstruction.

SPECIALTIES • Pediatric Ophthalmology • Adult Strabismus • Complicated Adult and Child Strabismus • Craniofacial Disorders

specializes in treating tumors and cancers of the eye and medical and surgical diseases of the retina and vitreous. He is Director of Ocular Oncology at Moran, with clinical and research interests in intraocular tumors, such as uveal melanoma and retinoblastoma, as well as tumors of the surface of the eye. His clinical and surgical interests also include retinal detachments, diabetic retinopathy, epiretinal membranes and macular holes, and macular degeneration. Dr. Hansen is actively involved in local and international outreach work, with a focus on building capacity through education and systems development.

SPECIALTIES • Vitreoretinal Diseases and Surgery • Ocular Oncology

Monika Fleckenstein, MD,

specializes in degenerative retinal diseases, including AMD. Working with Moran’s Sharon Eccles Steele Center for Translational Medicine (SCTM), Dr. Fleckenstein is an international authority on the design, conduct, and analysis of clinical trials in retinal diseases. She oversees the SCTM’s DREAM1 Study, which will determine how a prevalent gene-driven form of AMD progresses in patients and the appropriate stage in the disease to administer therapy.

SPECIALTIES • Degenerative Retinal Diseases • Intravitreal Drug Delivery in Exudative Retinal Diseases

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Eric Hansen, MD,

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Mary Elizabeth Hartnett, MD,

is a Distinguished Professor and holds the Calvin S. and JeNeal N. Hatch Presidential Endowed Chair in Ophthal­mology and Visual Sciences. She is Director of Moran’s Pediatric Retina Center and one of a few retina specialists internationally trained to diagnose and treat pediatric retina disorders. As PI of an NIHfunded laboratory, she studies conditions including reti­nopathy of prematurity and AMD. Dr. Hartnett has authored over 198 peer-reviewed publications and 36 book chapters, and created the first academic textbook on the subject, Pediatric Retina. She has delivered numerous national and international invited lectures.

Her awards include the PhysicianScientist Award from Research to Prevent Blindness, the Honor­ary Lecture Award and Scientific Contribution Award from Women in Ophthalmology, the Macula Society’s Paul Henkind Award and Arnall Patz Medal, ARVO’s Weisenfeld Award, and the Paul Kayser/RRF Global Award. She is an ARVO Gold Fellow.

SPECIALTY • Pediatric and Adult Retinal Diseases and Surgery

Ophthalmologists

MOR A N E Y E CE N T E R

Robert O. Hoffman, MD,

is Chief of the Division of Pediatric Ophthalmology and Eye Muscle Disorders, and Co-Medical Director of the Moran Global Outreach Division. He has special interests in retinopathy of prematurity, ocular genetics, craniofacial disorders, pediatric cataracts, and complicated strabismus, as well as local, regional, and international pediatric ophthalmology outreach.

Rachael Jacoby, MD,

specializes in diseases of the retina and vitreous. Her clinical and surgical interests include retinal detachments, diabetic retinopathy, and macular and retinal degeneration.

SPECIALTIES • Retinal Diseases and Surgery • Macular, Retinal Degeneration

SPECIALTIES • Pediatric Ophthalmology • Adult Strabismus

Marissa Larochelle, MD,

specializes in cataract surgery and the diagnosis and management of patients with infectious and inflammatory eye conditions.

She collaborates with rheumatologists, pediatricians, and internists to ensure uveitis patients receive optimum care.

SPECIALTIES • Uveitis and Ocular Immunology • Comprehensive Ophthalmology • Cataract Surgery

Griffin Jardine, MD,

Eileen Hwang, MD, PhD,

specializes in the medical and surgical treatment of children and adults with retina conditions such as AMD, diabetic retinopathy, diabetic macular edema, retinal vein occlusions, myopic degeneration, macular hole, epiretinal membrane, retinal tears, retinal detachment, retinopathy of prematurity, Stickler syndrome, Coats disease, familial exudative vitreoretinopathy, and traumatic eye injury. She participates in the University of Utah Vice President’s Clinical & Translational Research Scholars Program.

SPECIALTIES • Adult and Pediatric Retina Conditions and Surgery

specializes in pediatric eye diseases and adult strabismus.

He offers medical and surgical treatment for amblyopia, strabismus, pediatric glaucoma, anterior segment disorders, pediatric cataracts, retinopathy of prematurity, and nasolacrimal duct obstruction.

SPECIALTIES • Pediatric Ophthalmology • Adult Strabismus

Amy Lin, MD,

specializes in the medical and surgical treatment of corneal and anterior segment diseases.

She is Medical Director of the Utah Lions Eye Bank. Her interests include corneal transplantation, anterior segment reconstruction, cataract surgery, refractive surgery, and teaching residents and fellows.

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Nick Mamalis, MD,

is Director of the Ophthalmic Pathology Laboratory. He focuses his clinical practice on comprehensive ophthalmology, including cataract and other anterior ocular surgeries. Dr. Mamalis is immediate past president of the 8,000-member American Society of Cataract and Refractive Surgery (ASCRS). He is the editor emeritus of the Journal of Cataract and Refractive Surgery and is the author of over 200 peer-reviewed publications, one textbook, and 45 book chapters.

He is also Co-Director of the Intermountain Ocular Research Center and is performing research involving intraocular lenses and postoperative inflammation. Dr. Mamalis lectures throughout the world and was selected by Cataract and Refractive Surgery Today as one of 50 international opinion leaders.

His awards include the 2015 Life Achievement Honor Award from AAO and the 2013 Binkhorst Medal from ASCRS. SPECIALTIES • Cataract Services • Ophthalmic Pathology • Comprehensive Ophthalmology

SPECIALTIES • Corneal Transplantation • Cataract Surgery • Vision Correction Surgery (LASIK, PRK, Phakic Intraocular Lenses) • Ocular Surface Disease/Dry Eye Syndrome

Bradley J. Katz, MD, PhD,

specializes in neuro-ophthalmology, cataract services, and comprehensive ophthalmology.

He evaluates patients with diseases that affect the optic nerve and diseases of the brain that affect vision and eye movements.

SPECIALTIES • Cataract Services • Neuro-Ophthalmology • Comprehensive Ophthalmology

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Ophthalmologists

MOR A N E Y E CE N T E R

Douglas Marx, MD,

specializes in pediatric and adult oculoplastic and reconstructive surgery, particularly pediatric and adult orbital tumors, eyelid and orbital reconstruction, and congenital defects. His research interests include congenital ptosis; eyelid and orbital defects; thyroid disease; orbital inflammation; neoplasms; and reconstruction.

SPECIALTIES • Eyelid Reconstruction • Ptosis, Brow Ptosis • Ectropion and Entropion • Nasolacrimal Diseases • Orbital Tumors, Fractures • Pediatric Eyelid, Eye Socket, Tear Duct Abnormalities

Leah Owen, MD, PhD,

specializes in the medical and surgical treatment of pediatric eye disease, including cataract, nasolacrimal duct obstruction, amblyopia, retinopathy of prematurity, and strabismus. She also specializes in the surgical treatment of adult strabismus.

SPECIALTIES • Pediatric Ophthalmology • Adult Strabismus

Jeff Pettey, MD, MBA,

is Moran’s Vice Chair of Education; Residency Program Director; and Co-Medical Director, Moran Global Outreach Division. Dr. Pettey specializes in post-traumatic and complex cataract surgery.

His international work focuses on building training capacity through education and academic development. He was recognized by the American Academy of Ophthalmology for his ongoing local and international outreach work.

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Meagan Seay, DO,

specializes in neuro-ophthal­ mology and treats patients with neurological disorders that cause decreased vision or double vision, including abnormalities of the brain, optic nerve, and eye movements.

SPECIALTY • Neuro-Ophthalmology

SPECIALTIES • Complex Cataract Surgery • Complex Anterior Segment Surgery • Post-Traumatic Eye Injury

Akbar Shakoor, MD, Bhupendra C. K. Patel, MD, FRCS,

Mark D. Mifflin, MD,

is the Director of Cornea and Refractive Division, Chief of Surgical Services at Moran, and Associate Medical Director of the Utah Lions Eye Bank. He specializes in the medical and surgical treatment of corneal and anterior segment eye diseases, including expertise in all types of corneal transplantation, cataract surgery, and vision correction using lasers and intraocular lenses. Dr. Mifflin also directs Moran’s prestigious Cornea Fellowship Program.

SPECIALTIES • Cornea Transplant Surgery (Penetrating Keratoplasty, Lamellar Keratoplasty, Stem Cell Transplantation, and Eye Banking) • Cataract Surgery (Premium Intraocular Lenses, Monovision) • Vision Correction Surgery (LASIK, PRK, Phakic Intraocular Lenses)

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is a general surgeon, plastic surgeon, and ophthalmic surgeon, with training in the United Kingdom and the United States.

He has advanced fellowships in cosmetic and reconstructive head and neck surgery and also in ophthalmic plastic surgery, including orbital surgery, lacrimal surgery, socket surgery, and eyelid surgery. He has published three textbooks, including the 2020 edition of Orbital Tumors.

He has developed and published many new surgical techniques and designed surgical instruments used worldwide. He has an international practice and sees new patients as well as patients seeking second and third opinions. He regularly operates in Africa, Asia, and Europe. He is recognized as an expert in the management of thyroid orbitopathy, facial fractures, orbital tumors, blepharospasm, lacrimal surgery, and facial and eyelid tumors.

SPECIALTY • Oculoplastic and Facial Plastic Surgery

Steffen Schmitz-Valckenberg, MD,

is a Jon M. Huntsman Presidential Chair at the University of Utah.

He specializes in clinical and surgical treatment of macular and retinal diseases, including AMD, and is an expert in highresolution retinal imaging. He is Director of the Utah Retinal Imaging Reading Center (UREAD) at Moran, which has a key role in the SCTM’s drive to take a new therapy for a prevalent form of AMD into clinical trials.

SPECIALTIES • Macular and Vitreoretinal Diseases and Surgery

specializes in diseases of the retina and vitreous as well as uveitis and other infectious and inflammatory eye conditions.

His clinical and surgical interests include retinal detachments, diabetic retinopathy, epiretinal membranes and macular holes, macular and retinal degeneration, and the medical and surgical treatment of ocular inflammatory diseases such as uveitis. He is Director of the Uveitis Fellowship Program.

SPECIALTIES • Retinal Diseases and Surgery • Uveitis and Ocular Immunology

Ophthalmologists

MOR A N E Y E CE N T E R

Rachel G. Simpson, MD,

is Associate Program Director of Education. She specializes in the medical and surgical treatment of glaucoma and cataracts and in advanced anterior segment surgeries.

SPECIALTIES • Glaucoma • Cataract Surgery • Anterior Segment Surgery

Jean Tabin, MD,

provides urgent vision care and comprehensive ophthalmology services at Moran’s Triage Clinic. There, she treats patients for any emergency or urgent concerns regarding their vision or eyes while often teaching medical students and residents interested in learning more about ophthalmology.

SPECIALTY • Comprehensive Ophthalmology

Albert T. Vitale, MD,

is Director of Moran’s Uveitis Division and a member of the Vitreoretinal Division. He specializes in complex ocular inflammatory and infectious conditions, as well as diseases of the retina and vitreous. His research interests include ocular mani­festations of systemic diseases, novel therapeutic agents, new drug delivery systems in the treatment of ocular inflammatory disease, uveitic macular edema retinal vascular disease, and the pharmacotherapy of AMD. Dr. Vitale is co-author of the definitive text, with Dr. C. Stephen Foster, titled Diagnosis and Treatment of Uveitis.

SPECIALTIES • Uveitis and Ocular Immunology • Vitreoretinal Diseases

Brian C. Stagg, MD,

specializes in the diagnosis and treatment of glaucoma. He also performs cataract surgery and has a special interest in geriatric ophthalmology. During his residency at the University of Michigan, he practiced as a comprehensive ophthalmologist and was a national clinician scholar research fellow studying population health. He participates in the University of Utah Vice President’s Clinical & Translational Research Scholars Program.

Kim Taylor, MD,

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Barbara M. Wirostko, MD, FARVO,

is Resident Research Director and Adjunct Professor in Ophthalmology, with specialized fellowship training in glaucoma.

She treats glaucoma and comprehensive ophthalmology patients and specializes in clinical research. As a serial entrepreneur, she has large and small pharmaceutical company expertise and focuses on drug development for glaucoma pharmaceutical therapies. Her research interest is in sustained delivery of therapeutics for ocular pathologies and in better understanding the genetics and associated systemic diseases of exfoliative syndrome, a common cause of open-angle glaucoma.

SPECIALTIES • Comprehensive Ophthalmology • Glaucoma

practices comprehensive ophthalmology and has extensive experience in fitting contact lenses. He has many years of experience in diagnosing and treating eye diseases of all kinds.

SPECIALTY • Comprehensive Ophthalmology

SPECIALTIES • Glaucoma • Comprehensive Ophthalmology • Cataract Services • Geriatric Ophthalmology

Michael P. Teske, MD,

is Director of Vitreoretinal Diseases and Surgery. Dr. Teske specializes in medical and surgical diseases of the retina and vitreous. His primary surgical interests include retinal detachment, proliferative vitreoretinopathy, diabetic retinopathy, macular degeneration, epiretinal membranes, macular holes, and posterior segment trauma.

SPECIALTY • Retinal Diseases and Surgery

Judith E. A. Warner, MD,

is Chief of Neuro-Ophthalmology.

She evaluates complex visual complaints, which can be due to optic nerve or brain disease, and provides treatment for these disorders. Her interests include diplopia, giant cell arteritis, papilledema, optic neuritis, episodic vision loss, idiopathic intracranial hypertension, ischemic optic neuropathy, and unexplained vision loss.

SPECIALTY • Neuro-Ophthalmology

Marielle Young, MD,

provides medical and surgical care for children with eye disease as well as adults and children with strabismus. Her clinical expertise includes the evaluation and treatment of amblyopia, strabismus, infantile and developmental cataracts, and nasolacrimal duct obstruction.

SPECIALTIES • Pediatric Ophthalmology • Adult Strabismus

47

Ophthalmologists

MOR A N E Y E CE N T E R

Ophthalmologists continued

O T H E R S P E C I A LT I E S

Norm A. Zabriskie, MD,

Patrick G. Bakke, MD,

SPECIALTIES • Glaucoma Services • Cataract Services

SPECIALTY • General Anesthesiology

is Professor, Vice Chair, Medical Director of Clinical Service, Executive Director of Clinical Operations, and Director of Glaucoma. He specializes in the medical and surgical treatment of glaucoma and cataracts and has a research interest in the genetics of glaucoma.

is the Medical Director of Anesthesia Services at Moran.

Dr. Bakke provides and directs anesthesia care for ophthalmic patients before, during, and after surgery. His clinical interests also include anesthesia for labor and delivery, neurosurgery, and liver transplant, as well as the general practice of anesthesia.

Donnell J. Creel, PhD,

is Director of the Electrophysiology Service at Moran. The Electrophysiology Service provides examinations, including visually evoked potentials, full-field electroretinograms, auditory brainstem responses, electrooculograms, multifocal electroretinograms, and multifocal visually evoked potentials. These tests quantitate retinal, optic pathway, visual cortical, and brainstem auditory pathway function. Dr. Creel has written some of the most-read online chapters on these tests.

SPECIALTY • Electrophysiology

Brian E. Zaugg, MD,

specializes in the medical and surgical treatment of corneal and anterior segment eye diseases, including expertise in all types of corneal transplantation, routine and complex cataract surgery, anterior segment reconstruction, pterygium removal, and refractive surgery, including LASIK, PRK, phakic intraocular lens, and clear lens extraction. His research interests focus on improving efficiency and safety in cataract surgery as well as refractive surgery outcomes. Dr. Zaugg is a team ophthalmologist for the Utah Jazz and Real Salt Lake.

SPECIALTIES • Cornea Transplant Surgery • Ocular Surface Reconstruction (Pterygium Excision) • Cataract Surgery (Premium Intraocular Lenses, Laser Assisted Cataract Surgery, Monovision) • Vision Correction Surgery (LASIK, PRK, Phakic Intraocular Lenses, Clear Lens Extraction)

48

2 0 2 0 -2 0 2 1

Robert M. Christiansen, MD, FACS,

provides comprehensive vision rehabilitation services through Moran’s ophthalmology-based Patient Support Program. A nationally known expert in low-vision rehabilitation, he has been recognized by AAO with the Achievement Award and the Senior Achievement Award and by other organizations for his work with the partially sighted.

SPECIALTY • Vision Rehabilitation

Roger P. Harrie, MD,

directs the Ophthalmic Ultrasound Department at Moran.

He has been the senior instructor in the ocular ultrasound course at the annual AAO meetings and has published numerous articles, book chapters, and two textbooks. Dr. Harrie has made more than 50 humanitarian trips, mostly training doctors in developing countries in diagnostic and therapeutic techniques.

He directs the outreach program in examining and giving glasses to residents of the Salt Lake Valley Youth Detention Center.

SPECIALTY • Ophthalmic Ultrasound

Lisa Ord, PhD, LCSW,

is Director of the ophthalmology-based Patient Support Program for people with visual impairment and their families.

Services include counseling, support and education groups, vision rehabilitation, occupational therapy, information and referral services, and the Orientation to Vision Loss Program.

SPECIALTY • Psychosocial and Functional Issues Related to Vision Loss

Optometrists

MOR A N E Y E CE N T E R

2 0 2 0 -2 0 2 1

Robert H. Corry, OD,

Brandon J. Dahl, OD, FAAO,

Timothy L. Gibbons, OD,

Mark A. McKay, OD,

David Meyer, OD, FAAO,

Alan Morgan, OD,

Spencer D. Mortensen, OD, FAAO,

Dix H. Pettey, OD, MS,

Craig M. Smith, OD,

Bryan H. Vincent, OD,

specializes in ocular pathology, pediatric and general optometry, and contact lenses.

Redwood Health Center South Jordan Health Center

OPTOMETRISTS

is the Director of Contact Lens Services. He specializes in fitting contact lenses, primarily focusing on keratoconus, post-surgical corneas, pediatrics, irregular or high astigmatism, and fitting traumatized eyes. He also provides comprehensive eye care for glasses and soft contacts.

John A. Moran Eye Center Midvalley Health Center

specializes in comprehensive optometry, pediatrics, disease management with special emphasis on anterior segment disease, and contact lenses.

Parkway Health Center Westridge Health Center

practices comprehensive optometric eye care with special interest in contact lenses and dry eye management.

Farmington Health Center

Colleen S. Schubach, OD,

offers full-scope optometric eye care and contact lens services for all ages, with an emphasis on children and sports vision.

Redstone Health Center

specializes in comprehensive eye care with special interest in contact lenses, pediatrics, and ocular disease.

Stansbury Health Center Westridge Health Center Redwood Health Center

specializes in contact lenses, sports vision, and general optometry.

Westridge Health Center

specializes in children’s vision, sports vision, contact lenses, and general optometry.

Midvalley Health Center

specializes in full-scope optometric care, including adult and pediatric care, contact lenses, and job- or hobby-related visual needs.

John A. Moran Eye Center Redwood Health Center

specializes in fitting contact lenses for keratoconus, pediatrics, post-surgical, and eyes with severe or irregular astigmatism. He also provides comprehensive eye care for glasses and soft contacts.

Midvalley Health Center John A. Moran Eye Center

specializes in ocular pathology and contact lenses.

Midvalley Health Center John A. Moran Eye Center

49

Research Team

RESE ARCH

MOR A N E Y E CE N T E R

Alessandra Angelucci, MD, PhD

Wolfgang B. Baehr, PhD

Paul S. Bernstein, MD, PhD

Professor, Ophthalmology and Visual Sciences; Mary H. Boesche Endowed Professor of Ophthalmology and Visual Sciences

Professor, Ophthalmology and Visual Sciences; Ralph and Mary Tuck Presidential Endowed Chair of Ophthalmology and Visual Sciences

Professor and Director of Clinical and Basic Research; Val A. and Edith D. Green Presidential Endowed Chair of Ophthalmology and Visual Sciences

SPECIALTIES Visual Cortex Circuitry and Function

SPECIALTIES Phototransduction, the Retinoid Cycle, Membrane Protein Transport in Photoreceptors; Photoreceptor Biochemistry; and Molecular and Cell Biology

SPECIALTIES Vitreoretinal Diseases and Surgery; Retinal Biochemistry; Macular and Retinal Degeneration

Lara Carroll, PhD

Donnell J. Creel, PhD

Monika Fleckenstein, MD

Jeanne M. Frederick, PhD

Research Assistant Professor, Ophthalmology and Visual Sciences

Research Professor, Ophthalmology and Visual Sciences; Neurobiology and Anatomy; Neuroscience

Professor, Ophthalmology and Visual Sciences

Research Associate Professor, Ophthalmology and Visual Sciences

SPECIALTIES Corneal and Retinal Neovascular Diseases

50

2 0 2 0 -2 0 2 1

SPECIALTY Electrophysiology

SPECIALTIES Degenerative Retinal Diseases; High-Resolution Imaging; Identification of Prognostic Biomarkers for Disease Progression; Validation of Clinical Endpoints for Interventional Trials

SPECIALTY Retinal Cell and Molecular Biology

Gregory S. Hageman, PhD

Mary Elizabeth Hartnett, MD

Eileen Hwang, MD, PhD

Bryan W. Jones, PhD

John A. Moran Presidential Endowed Chair of Ophthalmology and Visual Sciences; Executive Director, Sharon Eccles Steele Center for Translational Medicine

Professor, Ophthalmology and Visual Sciences; Calvin S. and JeNeal N. Hatch Presidential Endowed Chair of Ophthalmology and Visual Sciences

Assistant Professor, Ophthalmology and Visual Sciences

Associate Professor, Ophthalmology and Visual Sciences; Direc­tor, Marclab for Connectomics

SPECIALTIES Genetics and Assessment of Pathways Involved in AMD Etiology; AMD Target Identification and Therapeutic Development

SPECIALTIES Retinal Angiogenesis Relating to ROP and AMD

SPECIALTIES Vitreous; Collagen; Extracellular Matrix; Aging; Protein Aggregation

SPECIALTIES Retinal Degeneration Disorders; Retinal Neurotransmission and Neurocircuitry; Metabolomics

BUILDING BRIDGES FROM RESEARCH TO PATIENT CARE

Bradley J. Katz, MD, PhD

Helga E. T. Kolb, PhD

David Krizaj, PhD

Professor, Ophthalmology and Visual Sciences SPECIALTIES Photophobia (abnormal light sensitivity); Migraine: its effects on visual quality of life; Ischemic Optic Neuropathy

Professor (Emerita), Ophthalmology and Visual Sciences, University of Utah; Doctor Honoris Causa, Universidad Miguel Hernandez de Elche, Spain; Editor, webvision.med.utah.edu

Professor and Deputy Director of Research; krizajlab.vision.utah.edu; John Frederick Carter Endowed Professor of Ophthalmology and Visual Sciences

Binxing Li, PhD

Nick Mamalis, MD

Robert E. Marc, PhD

Neda Nategh, PhD

Research Assistant Professor, Ophthalmology and Visual Sciences

Professor, Ophthalmology and Visual Sciences; Co-Director, Intermountain Ocular Research Center

Distinguished Professor (Emeritus), Ophthalmology and Visual Sciences

Assistant Professor, Electrical and Computer Engineering; Research Assistant Professor, Ophthalmology and Visual Sciences

SPECIALTIES Biochemistry and Biophysics of Macular Carotenoids; Mouse Models of Retinal Disease; Raman Imaging of Nutrients in the Retina

SPECIALTY Retinal Anatomy

SPECIALTIES Ocular Pathology; Comprehensive Ophthalmology; Intraocular Lens Research; Postoperative Inflammation

SPECIALTIES Retinal Neurobiology; Calcium Regulation; Glaucoma

SPECIALTIES Retinal Neurotransmission and Networks; Retinal Degenerations; Metabolomics

SPECIALTIES Visual Processing and Computations; Neuro-Inspired Computer Vision

Richard A. Normann, PhD

Behrad Noudoost, MD, PhD

Leah Owen, MD, PhD

Jeff Pettey, MD, MBA

Professor (Emeritus), Ophthalmology and Visual Sciences; Distinguished Professor of Bioengineering, University of Utah; Doctor Honoris Causa, Universidad Miguel Hernandez de Elche, Spain

Associate Professor, Ophthalmology and Visual Sciences

Assistant Professor, Ophthalmology and Visual Sciences

Associate Professor, Ophthalmology and Visual Sciences

SPECIALTIES Cognitive Neuroscience; Visual Processing

SPECIALTIES Analysis of Genetic and Genomic Contribution to the Pathophysiology of Complex Pediatric Eye Disease including Strabismus, Myopia, ROP, and Amblyopia

SPECIALTIES Cataract Surgery; Surgical Education

SPECIALTIES Artificial Vision/Neural Prosthetics

51

Research Team

MOR A N E Y E CE N T E R

2 0 2 0 -2 0 2 1

Steffen Schmitz-Valckenberg, MD

Brian C. Stagg, MD

Ning Tian, PhD

Frans Vinberg, PhD

Professor, Ophthalmology and Visual Sciences; Jon M. Huntsman Presidential Chair; Director, Utah Retinal Reading Center, uread.org

Assistant Professor, Ophthalmology and Visual Sciences

Professor, Ophthalmology and Visual Sciences; Adjunct Professor, Neurobiology

Assistant Professor, Ophthalmology and Visual Sciences

SPECIALTIES Population Health; Glaucoma; Personalized Medicine

SPECIALTY Retinal Neurobiology

SPECIALTIES Biomedical Engineering; Biophysics; Photoreceptor Physiology

SPECIALTIES AMD; Retinal Imaging; Fundus Autofluorescence; StructuralFunctional Correlation

Haibo Wang, MD, PhD

Liliana Werner, MD, PhD

Larry A. Wheeler, PhD

Jun Yang, PhD

Research Associate Professor, Ophthalmology and Visual Sciences

Professor, Ophthalmology and Visual Sciences; Co-Director, Intermountain Ocular Research Center

Research Professor, Ophthalmology and Visual Sciences

Professor, Ophthalmology and Visual Sciences

SPECIALTIES Ophthalmic Drug Discovery and Development; AMD; Pharmacology of Glaucoma; Dry Eye and Neuroprotection

SPECIALTIES Cell Biology of Photoreceptors; Retinal Diseases

SPECIALTIES Vascular Biology: abnormal vessel growth implicated in pathological neovascularization in AMD, ROP, and Diabetic Retinopathy

SPECIALTIES Ocular Biodevices Research; Different Intraocular Lens Designs; Materials and Surface Modifications; Interactions between Ocular Implants and Ocular Tissues

Oleg Yarishkin, PhD

Guoxin Ying, PhD

Moussa A. Zouache, PhD

Research Assistant Professor, Ophthalmology and Visual Sciences

Research Assistant Professor, Ophthalmology and Visual Sciences

Research Assistant Professor, Ophthalmology and Visual Sciences

SPECIALTIES Ion Channels; Mechanoelectrical Transduction; Neurodegenerative Diseases; Glia-Neuron Interactions

SPECIALTIES Retinal Degeneration Diseases; Neuroscience; Gene Therapy

SPECIALTIES Engineering; Mathematical Modeling; Data Analysis; Ophthalmic Drug Development; AMD

52

2020-2021

MORAN EYE CENTER ADJUNCT RESEARCH TEAM INTERNAL University of Utah

EXTERNAL

Paul Bressloff, PhD

Ferhina Ali, MD

Tiarnan Keenan, MD, PhD

Brittany Coats, PhD

Catherine Bowes Rickman, PhD

Edward Levine, PhD

Karen Curtin, PhD, MStat

Carter Cornwall, PhD

Anat Loewenstein, MD

Michael Deans, PhD

Margaret DeAngelis, PhD

Kristen Kwan, PhD

Eugene de Juan, MD

Philip Luthert, MBBS, FRCP, FRCPath, FRCOphth

Maureen A. Murtaugh, PhD

Eduardo Fernandez, MD, PhD

Jason Shepherd, PhD

Yingbin Fu, PhD

Monica Vetter, PhD

Sabine Fuhrmann, PhD

Barbara M. Wirostko, MD, FARVO

Werner Gellermann, PhD

Debra Schaumberg, ScD, OD, MPH Barry Willardson, PhD Lloyd Williams, MD, PhD

Li Jiang, MD, PhD

ADJUNCT VOLUNTEER OPHTHALMOLOGISTS

2020-2021

Adjunct volunteer faculty collaborate on research projects, participate in clinical studies, attend teaching opportunities, and assist on our outreach medical missions.

Jason Ahee, MD St. George, Utah

David A. Crandall, MD West Bloomfield, Michigan

Zachary Joos, MD Renton, Washington

Marcos Reyes, MD St. George, Utah

James Tweeten, MD Boise, Idaho

Iqbal “Ike” Ahmed, MD, FRCSC Mississauga, Ontario, Canada

Sonya Dhar, MD New York, New York

Khizer Khaderi, MD Sacramento, California

Trent Richards, MD Layton, Utah

Albert Ungricht, MD Salt Lake City, Utah

Jane Durcan, MD Salt Lake City, Utah

Krista Kinard, MD Spokane, Washington

Christopher Ricks, MD Provo, Utah

Jeremy Valentine, MD Provo, Utah

Jayson David Edwards, MD St. George, Utah

Victoria Knudsen, MD Murray, Utah

Sanduk Ruit, MD Kathmandu, Nepal

Aaron N. Waite, MD Lehi, Utah

David Faber, MD Salt Lake City, Utah

Elliott Kulakowski, MD Park City, Utah

Derek J. Sakata Salt Lake City, Utah

Gary Wallace, MD Idaho Falls, Idaho

William J. Fishkind, MD Tucson, Arizona

Robert C. Kwun, MD Murray, Utah

Joshua Schliesser, MD St. George, Utah

Matthew S. Ward, MD Provo, Utah

Roger C. Furlong, MD Butte, Montana

David P. Lewis, MD Brigham City, Utah

Loren S. Seery, MD Kennewick, Washington

Charles H. Weber, MD Oregon City, Oregon

Mitchell J. Goff, MD Salt Lake City, Utah

Majid Moshirfar, MD Draper, Utah

Avni Shah, MD Santa Rosa, California

Robert C. Welch, MD Twin Falls, Idaho

Reeta Gurung, MD Kathmandu, Nepal

Valliammai Muthappan, MD Sewickley, Pennsylvania

D. Snow Slade, MD St. George, Utah

Brice J. Williams, MD, PhD Ogden, Utah

Anna Gushchin, MD Hines, Illinois

Anastasia Neufeld, MD Vancouver, British Columbia, Canada

Robert E. Smith, MD West Valley City, Utah

Darcy Wolsey, MD Salt Lake City, Utah

R. Doyle Stulting, MD, PhD Atlanta, Georgia

Gilbert C. Wong, MD West Jordan, Utah

Russell Swan, MD Sioux Falls, South Dakota

DonRaphael Wynn, MD Boise, Idaho

Scott O. Sykes, MD Ogden, Utah

Zachary J. Zavodni, MD Salt Lake City, Utah

Arwa Alsamarae, MD Santa Rosa, California Lisa Arbisser, MD Sarasota, Florida Nicholas Behunin, MD St. George, Utah John Berdahl, MD Sioux Falls, South Dakota Ronnie Bhola, MBBS St. Augustine, Trinidad Eric Brinton, MD Salt Lake City, Utah Gregory Brinton, MD Murray, Utah Michael Burrow, MD Salt Lake City, Utah Kristin O. Chapman, MD Salt Lake City, Utah Joseph Chen, MD Ventura, California Robert J. Cionni, MD Salt Lake City, Utah Richard P. Corey, MD Salt Lake City, Utah

Bradley Hansen, MD Idaho Falls, Idaho Matheson A. Harris, MD Salt Lake City, Utah Joseph L. Hatch, MD Salt Lake City, Utah James G. Howard, MD Murray, Utah Todd Jackson, MD Las Vegas, Nevada

Tom Oberg, MD Salt Lake City, Utah Samuel F. Passi, MD Salt Lake City, Utah Hreem Patel, MD Stickley, Illinois David B. Petersen, MD Salt Lake City, Utah

Geoff Tabin, MD Palo Alto, California Robert L. Treft, MD Layton, Utah

53

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

The following individuals and organizations contributed to the Moran Eye Center from July 1, 2019, to June 30, 2020.

DONORS F IS CA L Y E A R 2 02 0

gifts of

$1,000,000 a n d

above

Dr. Ezekiel R. and Edna Wattis Dumke Foundation Olson-Huntsman Vision Foundation

gifts of

$100,000 a n d

above

Anonymous | Alcon Research Ltd. Eveline Bruenger* | Lawrence T. and Janet T. Dee Foundation Thomas and Candace Dee Family Foundation | Christine A. and Fred W. Fairclough Foundation Fighting Blindness | Hoya Medical Singapore, Pte., Ltd. The Huntsman Foundation International Retinal Research Foundation, Inc. | Knights Templar Eye Foundation, Inc. Lowy Medical Research Institute | John A. and Carole O. Moran Ruth L. and Randall J Olson, MD | Research to Prevent Blindness, Inc. Sharon Steele-McGee | Steinbeis Transfer GmbH | Bart and Elizabeth Warner

gifts of

$50,000 a n d

above

Anonymous | Atia Medical | Toni F. Bloomberg Val A. Browning Foundation | Everett P. and Mary Kay Davis Val A. and Edith D. Green Foundation, Inc. | Harvard University The Mitchell & June Morris Foundation | Onpoint Vision Joseph & Kathleen Sorenson Legacy Foundation | The Sorenson Legacy Foundation

54

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

gifts of

$25,000

and above

William H. and Patricia W. Child The Chrisman Foundation Katherine W. & Ezekiel R. Dumke, Jr., Foundation Willard L. and Ruth P. Eccles Foundation Willard L. Eccles Charitable Foundation David Kelby Johnson Memorial Foundation Ruth M. Lieder* Constantine S. Macricostas The Mark and Kathie Miller Foundation George and Pauline Mulligan The Olch Family Alaskan Trust Pan-American Ophthalmological Foundation

Rodney H. and Carolyn H. Brady Foundation

Utah Lions Foundation

The Jeffrey and Helen Cardon Foundation

James W. and Jeanne J. Welch

David L. and Kerry E. Carlson

gifts of

Cristalens Industrie

Anonymous

Stephen G. and Susan E. Denkers Family Foundation

Associated Properties, LC

Errol P. and Sonja Chesley EerNisse William and Fern England Foundation Eye Corps, Inc.

Teri and Dean Flanders Foundation Foster and Lynn Friess Grandeur Peak Global Advisors, LLC

Retina Research Foundation Hazel M. Robertson*

Stephen and Lynda Jacobsen Foundation

Noel* and Florence C. Rothman Family

Judelson Family Foundation

SpyGlass Ophthalmics, Inc.

Klintworth Family Foundation

Story Garschina Foundation

Dennis and Laurel Lallman

Marva M. and John E. Warnock, PhD

Lindsey and Jon Little James M. and Alison R. Luckman Thomas O. and Diane J. Might

Anonymous

Elahe A. Mostaghel, MD, PhD

Altabank

Keith and Ginger Myers

ARCS Foundation Inc., Utah Chapter

National Christian Foundation

Bamberger-Allen Health and Education Foundation

Dave and Donna Newberry

Brent and Bonnie Jean Beesley Foundation

Byron B. and Deborah K. Barkley David W. Bernolfo Kurt Bestor

Burningham Foundation

Drue B. Huish

William J. and Sara S. Barrett

Fred and Linda Babcock

Thomas H. and Carolyn L. Fey Family Foundation, Inc.

Refocus Group, Inc.

and above

and above

Brickwork Offices

Margaret D. Hicks

$10,000

$5,000

Joan and Tim Fenton Family Foundation

Perfect Lens, LLC

gifts of

Wattis Dumke Foundation

Q10 Bonneville Real Estate Capital Susan O. Taylor Haru H. Toimoto

Steven Brouillette Irrevocable Trust The Castle Foundation Howard S. and Betty B. Clark Kirsten Merinda Cobabe Frank H. and Susan L. Countner E. Steve and Sukie Crandall G. Frank and Pamela M. Joklik Alan S. and Leslie P. Layton Kay W. Lipman Vincent P. and Janet Mancini Larry H. Miller Charities My Brother’s Keeper Foundation Linda Rankin, PhD William K. and Julia D. Reagan Helene H. Richer Richard A. and Carmen Rogers Katherine G. Schlein Alvin V. and Sally Shoemaker James M. Steele and Linda L. Wolcott Naoma Tate W. James and Elizabeth F. Tozer Mikel Trapp 55

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Nicholas J. and Nancy W. Ward

The Dorsey & Whitney Foundation

William and Suzelle McCullough

James R. and Linda R. Wilson

Jane Durcan, MD, and John Hoffman, MD

Philip M. and Susan L. McLaughlin

Eide Bailly, LLP

Vicki B. Merchant David J. Miller

Anonymous

Henry W. & Leslie M. Eskuche Foundation

George M. Ahn

Rex E. Falkenrath and Amy S. Paul

Balamurali K. Ambati, MD

Jack M. and Marianne Ferraro

Barry J. and Catherine F. Angstman

John H. and Carol W. Firmage

Karen S. and David R. Bachman

John H. and Joan B. Firmage

Georgia Ball

Dan and MJ Forman

Flora V. Barrus

Cecelia H. Foxley, PhD

Bonnie Barry

David W. and Luella B. Freed

Bhupendra B.K. Patel, MD, FRCS, and Anne M. Kennedy, MD

Janette H. Beckham

Eugene* and Claire Freedman

Dinesh and Kalpana Patel Foundation

Maryam R. Beigi, MD

Richard K. Frerichs and Jean Zancanella

Gretchen and Jeff Pettey, MD, MBA

Lisa and William M. Wirthlin gifts of

$1,000

and above

Joseph C. and Gainor L. Bennett William F. and Victoria F. Bennion Ann P. and Paul S. Bernstein, MD, PhD BCWM Carolyn H. Brady Howard R. and Victoria S. Brady Michael J. and Patricia Brill Robert S. Carter Foundation Irene G. Casper and Ruth A. Morey Chic & Disheveled Jeffrey K. and Jane Cobabe The Honorable Suzanne B. Conlon Richard L. and Janice M. Corbin Julie and Alan* S. Crandall, MD F. Anthony and Joyce G. Crandall Robert W. and Carol N. Culver Karen P. Curtin, PhD, and William B. Wegesser, PA-C Margaret DeAngelis, PhD, and Michael Feehan, PhD

56

David P. and Sheila S. Gardner Nathaniel Goodman

Esther R. Medina

Moreton Family Foundation J. Bill and Judith E.C. Moschetti Reza K. Nejad, MD NG Foundation Inc. O.C. Tanner Company Suzanne E. Oelman

Brent and Tina Price Charlotte A. Quinn Residuary Trust

Elizabeth Gray

Frederick Quinn and Carolyn Tanner Irish

Mark H. and Mildred M. Hafey

S.J. & Jessie E. Quinney Foundation

Albert Halprin and Janice Obuchowski

David P. and Suzanne J. Razor

C. Charles and Elise Hetzel

Ronald Reaveley

Carolyn S. and Robert O. Hoffman, MD

Don B. Reddish

Anne C. and John T. Hopkin, MD

Marjorie Riches Gunn

John C. Jarman

Derek J. Sakata, MD, and Cindy Sumarauw, DDS

Cameron and Jill Jensen

David E. and Lois P. Salisbury

Mildred M. Jensen*

Susan B. Schulman

Simone E. Kent

Shiebler Family Foundation

KMS Financial Services

Snowbird Ski & Summer Resort

Mel and Wendy Lavitt

Sole Fitness

Robert B. Lence, Jr.

Howard S. Spurrier, DDS

James L. Macfarlane

John R. and Helen B. Stone

Mercy and Nick Mamalis, MD

Lisa Stout, MD

Nick and Jen Markosian

Kent P. and Dana L. Strazza

Milo S. and Karen J. Marsden

R. Anthony Sweet

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Lary J. and Judy W. Talbot

Randall and Arlene C. Bartholomew

Beverly L. Chandler

Virginia S. and Verl H. Talbot, MD

James H. and Donna Bath

VonDel and Becky Chapman

John Cramer Terrill

Thomas and Margaret Bath

Kristin O. Chapman, MD

Trolley Art & Antique

James C. Beardall

Kathleen Chatelain

United Jewish Community Endowment Trust

L. Steven and Melody Beck

Michelle and Craig J. Chaya, MD

David W. Becker, Jr., MD, JD

Cheesecake Factory

Joseph S. and Margaret P. Viland

John E. Bendixen

Qing Chong

Albert T. Vitale, MD, and Patricia Vitale, MD

Scott Bergeson

Paul R. Christenson

Kurt and Betsy Bernhisel

Kurt Christiansen

Cynthia A. and Gary W. Wallace, MD

Betty Bianchi

James A. and Margaretha Church

WCF Mutual Insurance Company

John A. and Dee Bianucci

Joann Coyte Cissel

Larry A. Wheeler, PhD

William E. and Alice S. Bierer

Dave and Ann G. Cline

Dolph A. and Becky E. Woods

BJK Investments of Wyoming, LLC

Phillip W. and Susan D. Clinger

Robert C. and Patience Ziebarth

Bonnie B. Blanchard

Sherman W. and Susan Clow

Elmen D. and Monika Bloedel

John and Patricia H. Cofer

Arlyn R. and Norma J. Bodily

Brad D. and Jolie Coleman Hardy

Anonymous

Sheri A. Bodily

Linda Kay Chipman Coleman

Hans G. Ahrens

Vi Braden

Marian A. Connelly-Jones

Alcohol Servers Training of Utah, LLC

Lyman and Jane Brothers

Drury W. Cooper, III

James A. and Carol A. Anderson

Lewis J. Brown, MD

Craig R. and Jan A. Crockett

Milton M. and Dianne K. Anderson

J. Steven* and Susan J. Brown

Dorothy B. Cromer Family Trust

Neal R. Anderson

Jean and William Buhl

Paul B. Crookston

Ronald I. Apfelbaum, MD, and Kathleen A. Murray

David C. Burke

Charles H. Culp

Burt Brothers Tire & Service, Inc.

Mary L. Daines

Busath Photography

Michael K. Damron

Darryl P. and Ann L. Butt

Helen De La Cruz

Raymon A. Bybee

Nancy DeCamp

Cactus & Tropicals, LLC Linda J. Campbell

Michael Deininger, MD, and Jutta Deininger, APRN

James D. Caras

Lynn and Dixie Denney

Randall C. Carlisle

T. Jerald and Carol D. Diana

John and Shirley Carmack

Cameron and Rachel Diehl

Mike and Argie A. Carmichael

Kathleen B. Digre, MD, and Michael W. Varner, MD

gifts of

$ 10 0

and above

Asart Design Alan C. and Karen Ashton Pamela J. Atkinson Ekhlas A. Attia Robert K. Avery and C. Frances Gillmor Leah A. Baker* Brock K. Bakewell, MD Ballet West Allen P. and Kathy J. Barber Margaret D. and Bryce G. Barker, MD Fern E. Bartholomew

John D. Carnahan Keith E. Carson Living Trust F. Burton Cassity

Vera Caren Dixon Wilma F. Dolowitz 57

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Keith Downey

Nancy H. Hajek

Allison B. Jacobsen

Elwin and Lois Dutson

Ronald C. Hamblen

Stanley Clyde Jardine

John S. and Evelyn B. Edwards

Cliff Hammer

Eileen G. Jenkins

Karen Ehresman

Connie Hancock

Jensen Charitable Foundation

Elsie Erickson

Jim and Gloria J. Hannon

Linda H. Jensen

Dennis D. and Carma B. Ewing

Sandra Coggle Hanseen

Norman S. and Gail R. Jensen

Richard “Reese” Feist, Jr., MD, and Stephanie Schick

Heather B. Hansen

Marie C. Johnson

Jacki Hansen

Amy Jones

Theresa Ferraro

Kim R. Hansen

Marika and Dean Jones

Bruce R. and Carole E. Fishburn, MD

Lynda Hansen

Robert G. Jones

Fishkind, Bakewell, Maltzman, Hunter & Associates Eye Care and Surgery Center

Phillip and Mary Lou Hansen

Ryan C. and Jaime L. Jones

Gareld D. Hanson Helga Hardin

Kamas Valley Lions Club Service Project

Douglas Hattery

Stephen C. and Uta I. Kappler

James V. and Gail Hawkins

Mary M. Katsanevas

Vanessa Hendricks

Richard A. Kennedy

R. Jeff Higgins

Paul and Geraldine Kilpatrick

Highmark Enterprises, LLC

Judith Kittleson

Daniel Hill

Julia J. Kleinschmidt, PhD

Einar B. and Madora I. Hoff

Gregory F. Klomp, MD

Carol Holding

JoAnn Koberg

Andy Hollenbeck

Barbara Brittain Korous

Home Source Realty, Inc.

Layne A. and Sandra Kresser

Clair R. Hopkins Jr., DMD, PC

La Caille

Jeanne M. Howerton

Roger O. Ladle

John J. Huebner

Nelson V. Laird

Edward L. Hughes and Roberta L. Anner-Hughes

Darrell R. and Julie Larsen

Daniel C. and Gloria J. Hurlbutt

Byron D. and Marjean B. Larson

Thelma P. Iker

Marilee C. Latta

Albert Imesch

Paul H. Laver

Harry F. Immerman

Harriet T. Lawrence

Indian Wells Tennis Garden

Frank and Barbara Layden

Pamela J. Irwin

Timothy G.* and Suellen R. Lee

Allen L. and Kathleen A. Isaac

Jeremy LeFevre

Bentley L. Isom

Amy Lin, MD

Russell F. and Barbara C. Fjeldsted Frank W. and Elaine T. Fox Michelle France Bernard I. and Margery G. Friedlander Brian L. and B.J. Fullmer William L. and Juanita C. Furlong G.S. and Kay Gallacher D. Jay Gamble, JD Richard B. and Anne W. Gappmayer Paul E. Garland, MD Kevin P. Gates Caroline Gaudy Dietrich K. and LaDon M. Gehmlich Nicholas and Courtney Gibbs Takashi and Tamara Gibo William A. and Claudia M. Gislason Stephen V. and Leslie Goddard Marrdella Goehring Robert M. Graham, JD The Grand America Hotel Bernard I. Grosser, MD, and Karen J. McArthur Ruiling Guo James R. Haisley and Barbara E. Bean 58

Suzanne W. and Gary F. Larsen, MD

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Thurman and Barbara Locke

Jeanette Nice

Dana D. Pollock

Carol and Samuel D. Loftin

Jay B. and Deanna L. Nielsen

Herbert H. Pollock

Loveland Living Planet Aquarium

Brent T. Nilsen

Donald R. and Joyce M. Polster

Dr. Denis R. and Diane Robards Lyman

Van B. and Maude E. Norman

Teresa A. Polychronis

James K. Lyon and Dorothy Burton Lyon

Vincent Novack

Elaine Pomeranz

Dr. Ruth L. Novak

David J. and Vicki MacKay

Margie Novich

John and Marcia Price Family Foundation

David and Marilyn Maher

Oasis Cafe–Golden Braid Books

Prodigious Entertainment

Chris and Sharon C. Mancini

Richard T. and Edith H. O’Brien

John R. Prokos and Melinda R. Baas

Market Street Grill/New Yorker

Joan J. Odd

Jacqueline Kim Pullos

Collette Marthia

Richard B. and Linda M. Odemar

Scott and Karin Pynes

Tawnja Stout Martin

Trevor W. and Channing J. Olch

Virginia H. Quinn

Kurt Matzen

Stephen and Barbara Olchek

Arthur B. and Susan M. Ralph

Willard Z. and Rona Lee Maughan

Lisa Marie Ord, PhD, LCSW

Vandana Raman, MD

Les E. and Therese M. Mayes

Eugene Overfelt

Diana L. Ramirez

Robert A. and Lee Anne McConnell

Ted and Kay Packard

Jerry W. and Pamela I. Rankin

Lori Leeann McCoy

Brent Palfreyman

V. Raman and Elizabeth D. Rao

Marshall Wade McEntire

Douglas D. and Joan B. Palmer

Patrick and Gwen Reddish

Marvin and Renee Melville

James R. and Patricia Patton

Barbara G. Reese

Lloyd R. and Marjorie R. Merrill

Stephen C. Paul, DDS

Jeff and Heidi Reid

Betsy J. Minden

Andrew Pendleton

Ronald L. Rencher, JD

Ruth S. Moesser

Jess N. and Lisa A. Peters Revocable Family Trust

Burt T. Richards, PhD

Montana Academy of Ophthalmology, Inc.

Mary and Arnold Richer

Elaine Peterson

Ed Robinson

Casey E. and Daysha Moore

Gary G. and Lynn Peterson

Janie L. Rogers

James R. Moore and Kathryn Lindquist

Raymond R. Peterson

Tonya Rogers

Tony and Mary Ann Morgan

University of Utah– College of Pharmacy

Rowland Associates

Mountain Property Services, Inc.

Tamara Phillips

Gary and Lisa Mulcock

Kent S. Sakashita

Warren S. Phillips

Margaret K. Mumford

Salt Lake Swimming & Tennis Club

Robert D. and Lyddia Pierce

Anna Marie Naylor

Mary Ann Scott

Marilyn H. Neilson

Roy W. and Elizabeth E. Simmons Pioneer Memorial Theatre

Richard A. Shriver

Marie W. Nelson

Martha A. Pittard

Russell A. and Dianne C. Nelson

Howard and Sharon Poch

Newpark Resort

Keith G. and Beverly J. Polinoski

Sylvia C. Newton

Pollock Enterprises, LLC

Leonard H. and Alene M. Russon

David K. Sias Roger and Kristine L. Sjoblom Jonathan and Liz Slager Vicki Ann Slotte 59

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Richard and Jenny Smartt

Vivian Dowsett Interiors

Colleen H. Bowman

Marynell Snow

Rourke H. Bowman

South Salt Lake Lions Club

I. J. & Jeanne Wagner Jewish Community Center

Roy A. Spjut

Ann T. Wagstaff

LaRee Page Brown

Sports Den

Verdon R. and Laurene S. Walker

Laura J. Springhetti

M. Walker and Sue R. Wallace

Bill Buhl

Stanza Italian Bistro & Wine Bar

W. Jeffrey and Mona Walters

Michael H. Stevens, MD

Haibo Wang, PhD

David and Londa Stout

Matthew and Lynn W. Ward

Lamont and Yvonne Stuart

Adam M. and Judith A. Warden

Zelda K. Svilar

Gary H. and Garda L. Wardle

Thomas and Marsha Swegle

Charles Weber, MD, and Lana Smith Weber, MD

Takashi Barbara L. Tanner* William W. and Elizabeth F. Tanner William R. Tanner and Susan D. Heath Sally A. Taylor R. Burke Teichert Gretchen and Michael P. Teske, MD Thanksgiving Point Daniel M. and Carol C. Thomas John R. Thomas and Jennifer C. Lawton Marva Thomas Michael A. and Dinny T. Trabert Tracy Aviary Roger L. Tucker Timothy J. and Patricia K. Tulon Jim and Candy Turnbull Randy and Susan Turpin Ingrid and Stephen Tyler Douglas Unger Utah Jazz Utah Olympic Park Deane Van Wagenen L. Craig and Margaret B. Vernon Milan Vinich 60

Bart L. and Marlene G. Wheelwright Alice L. Whitacre Pauline Wiessner, PhD Wild Rooster Artworks Joleen Willey Brandi Williams, PhD Stephen P. and Nancy Z. Williams Willow Creek Country Club

Lauren Elyse Bradley

Lyman Buhler Dorothy B. Burton Kent M. Campbell Willa Dean Cocorinis Bianca Coppa Ruth Haglund Craig Helen Daly Uhalde Edmund W. Dumke Ernest Earl Joachim Enge Charlene Evans Allen W. Knox Fitzpatrick, Jr., MD Burton L. Gordon Ruth A. Hensel Belva B. Higgins

Kathryn C. Wilson

Lois F. Horne

Kurt Wimberg

Kim A. Howes

Pamela and Robert W. Wing, MD

Alan E. Huish

Judy Wolfe

Norman C. Jensen

William A. and Hope H. Worner

William M. Kleinschmidt

Mary Ann Wortley

Ray Larsen

Taylor M. and Sherrie Wray

Margaret Weber Martinez

Jeffrey and Vanessa Wright

Paul R. Martinez Gayland Mason

IN M E M O R Y O F Those in whose memory gifts were made to the Moran Eye Center from July 1, 2019 through June 30, 2020.

Phillip J. Mataya

Curtis E. Ackerlind, Jr.

Delmer O’Connell

Martha S. Ahrens

Ted H. Olsen

Teresa Kay Beardall

Julie C. Palfreyman

Barnie P. Bobbitt

Judith C. Peterson

Nassim A. Mostaghel Steven J. Nichols

Donor Report for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Lynda Rae Peterson

Rick Hannon

Donald Cathcart

Darlene M. Phillips

Mary Elizabeth Hartnett, MD

Tim and Candace Dee

Charlene Polychronis

Billie Jo Jones

Richard A. and Carol M. Fay

Hazel M. Robertson

Curt Jones

Daniel Forman, MD

Ruby M. Slotte

Gracie Jones

Frank and Elaine Fox

James R. Svilar

Travis Jones

Lester L. Thomas

David R. Lewis, PhD

Bernard Grosser, MD, and Karen McAthur

Richard Dick Tomlin

Amy Lin, MD

William B. Hale*

Warren Jensen Walters

Allie M. Mecham

Cliff Hammer

Lillis Wood Woodall

Mark D. Mifflin, MD

Joseph Hatch, MD

Paul J. Zabolotney

Moran Eye Center External Relations

Claudia and Jerry Howells

Lillian Zancanella

Randy Moseman

Curtis and Lynne Kennedy

Majid Moshirfar, MD

Thomas and Wendy Lacy

Randall J Olson, MD

John and Carole Moran

Senator Rand Paul, MD

Sylvia E. Prahl-Brodbeck

Jeff Pettey, MD, MBA

Ruth L. and Randall J Olson, MD

David W. Bernolfo

Joyce Phillips

Linda Rankin

Gayle Brooks

Pat Phillips

Don Reddish

Ryan Colby Campbell

Charles Pieper

Janet Schaap

F. Burton Cassity

Marion Raish

Edward Skinner

Craig J. Chaya, MD

Chris Reddish

Daniel Soulia

Richard O. Christiansen

Jonathan Tanner Reddish

Sharon Steele-McGee

Kim Corbin-Lewis, MD

Patrick M. Reddish

Susan O. Taylor

Alan S. Crandall, MD*

Akbar Shakoor, MD

Mary E. Thompson

David Alan Crandall, MD

Dinny Trabert

Haru Toimoto

Julie T. Crandall

Norm A. Zabriskie, MD

IN H O N O R O F Those in whose honor gifts were made to the Moran Eye Center from July 1, 2019 through June 30, 2020.

Lisa Z. Crandall

Fred W. Fairclough, Jr.

P L A N N E D G IF T S Those who have planned gifts in place to the Moran Eye Center as of June 30, 2020

Luella B. Freed

Joanne Ambrose

Heidi L. Furlong

Neal R. Anderson

Roger C. Furlong, MD

Karen S. and David R. Bachman

Sergio Gor

Bonnie Barry

Gloria J. Hannon

Elmen D. Bloedel

Jim Hannon

Irene G. Casper and Ruth A. Morey

LaVerne A. Diehl Christine A. Fairclough

The Moran Eye Center is grateful for the contributions made to support our mission and goals. We have made every effort to ensure that this July 1, 2019 through June 30, 2020, Donor Report is as accurate as possible. Should you find an error or wish to change your listing, please contact us at 801-585-9700. *Deceased

61

MOR A N E Y E CE N T E R

At a Glance

JULY 1, 2019-JUNE 30, 2020

Oculoplastic: 538

$8,616,674

GRANTS AND CONTRACTS

Other: 423

94

CLINICAL TRIALS/STUDIES

180

PUBLICATIONS

S UR GE R IE S P E R FOR ME D

Retina: 647

7,031

Pediatric: 1,435 Anterior Segment: Glaucoma, Cataract, and Cornea: 3,988

View a complete listing of grants, clinical trials, publications, and more at bit.ly/MoranAnnualReports.

PAT IE N T V ISI T S

175 Low Vision Neuro4,176 Ophthalmogy

135,825

4,415 5,588 10,735 14,205 14,943 16,130 17,032

23,403 25,023

62

Uveitis Oculoplastic Other Glaucoma Pediatric Retina

Cornea/Refractive Optometry Comprehensive Ophthalmology

At a Glance

MOR A N E Y E CE N T E R

U.S. NEWS & WORLD REPORT

JULY 1, 2019-JUNE 30, 2020

DOXIMITY

No. 9 Nationwide No. 2 in the West for Residency Education

13th Nationwide Best Hospitals for Ophthalmology

VIZIENT

University of Utah Health ranks No. 1 Nationwide for Inpatient Quality No. 2 for Ambulatory Quality

E X P E R T S ON E X P E R T S

We’re proud and honored to share the news that a panel of our peers—chairpersons and directors of academic programs across the country—voted the John A. Moran Eye Center at the University of Utah No. 11 in the nation—and that’s not all.

Ophthalmology Times

3

4 5

6

WILMER EYE INSTITUTE Johns Hopkins University; BASCOM PALMER EYE INSTITUTE University of Miami MASSACHUSETTS EYE AND EAR Harvard University W.K. KELLOGG EYE CENTER University of Michigan WILLS EYE HOSPITAL Thomas Jefferson University DUKE UNIVERSITY EYE CENTER Duke University Hospital

OF IOWA 7 UNIVERSITY Carver College of Medicine & DOHENY EYE INSTITUTE 8 STEIN University of California, Los Angeles EYE INSTITUTE 9 CASEY University of Oregon COLE EYE INSTITUTE 10 Cleveland Clinic MORAN EYE CENTER 11 University of Utah BYERS EYE 12 STANFORD UNIVERSITY

RESIDENCY PROGRAM

RESEARCH PROGRAM

OVERALL PROGRAM 1

2020 Survey Results

1

WILMER EYE INSTITUTE Johns Hopkins University

2

MASSACHUSETTS EYE AND EAR Harvard University

3

4 5

6

W.K. KELLOGG EYE CENTER University of Michigan BASCOM PALMER EYE INSTITUTE University of Miami DUKE UNIVERSITY EYE CENTER Duke University Hospital STEIN & DOHENY EYE INSTITUTE University of California, Los Angeles

EYE INSTITUTE 7 CASEY University of Oregon EYE INSTITUTE 8 COLE Cleveland Clinic EYE 9 BYERS Stanford University UNIVERSITY OF IOWA 10 Carver College of Medicine WILLS EYE HOSPITAL 11 Thomas Jefferson University MORAN EYE CENTER 12 University of Utah

1

2

3

4

BASCOM PALMER EYE INSTITUTE University of Miami MASSACHUSETTS EYE AND EAR Harvard University WILMER EYE INSTITUTE Johns Hopkins University WILLS EYE HOSPITAL Thomas Jefferson University

KELLOGG EYE CENTER 5 W.K. University of Michigan OF IOWA 6 UNIVERSITY Carver College of Medicine UNIVERSITY EYE CENTER 7 DUKE Duke University Hospital EYE INSTITUTE 8 CASEY University of Oregon MORAN EYE CENTER 9 University of UtahCarolina STEIN & DOHENY EYE INSTITUTE 10 University of California, Los Angeles COLE EYE INSTITUTE 11 Cleveland Clinic ROCKY MOUNTAIN LIONS EYE 12 University of Colorado

CLINICAL PROGRAM 1

BASCOM PALMER EYE INSTITUTE University of Miami

2

WILMER EYE INSTITUTE Johns Hopkins University

3

4 5

6

WILLS EYE HOSPITAL Thomas Jefferson University MASSACHUSETTS EYE AND EAR Harvard University UNIVERSITY OF IOWA Carver College of Medicine W.K. KELLOGG EYE CENTER University of Michigan

UNIVERSITY EYE CENTER 7 DUKE Duke University Hospital EYE INSTITUTE 8 COLE Cleveland Clinic EYE INSTITUTE 9 CASEY University of Oregon STEIN & DOHENY EYE INSTITUTE 10 University of California, Los Angeles EMORY EYE CARE CENTER 11 Emory University MORAN EYE CENTER 12 University of Utah

Last Look

REFLECTIONS

By Michael Schoenfeld, November 24, 2020 64

Community Clinics

MOR A N E Y E CE N T E R

2 0 2 0 -2 0 2 1

Layton Farmington Farmington Health Center 165 North University Ave. University of Utah Hospital

Primary Children’s Hospital

Moran Eye Center 65 Mario Capecchi Drive

215

Park City

100 South

80

Redstone Health Center 1743 West Redstone Center Drive Suite 115

500 South

Salt Lake City 700 East

Tooele

Dr

State Street

15

hill

Redwood Road

400 South

t Foo

Stansbury Health Center 220 Millpond Road Suite 100

80

2100 South

Redwood Health Center 1525 West 2100 South

3500 South

West Valley City

South Salt Lake State Street

215

15

Murray

Midvalley Health Center 215 243 East 6100 South

Redwood Road

Bangerter Highway

4700 South

Westridge Health Center 3730 West 4700 South

West Jordan

3300 South

Sandy South Jordan Health Center 5126 West Daybreak Parkway

10600 South

South Jordan 11400 South

Draper

12600 South

Riverton Moran Eye Center Clinic at Intermountain Riverton Hospital 3773 West 12600 South Suite 301

15

The John A. Moran Eye Center at the University of Utah is the largest ophthalmology clinical care and research facility in the Intermountain West, with more than 60 faculty members, 10 satellite clinics, and 15 research labs.

Parkway Health Center 145 West University Parkway

Orem

Physicians provide comprehensive care in all ophthalmic subspecialties, making Moran a major referral center for complex cases. Services include:

Cataracts Cornea & External Eye Disease Electrophysiology Emergency Care Glaucoma LASIK and Vision Correction Surgery

Neuro-ophthalmology Oculoplastic and Facial Plastic Surgery Ocular Oncology Optometry Patient Support Program for Patients with Vision Loss

Pediatric Ophthalmology Pediatric Retina Retinal Diseases Strabismus Ultrasound Uveitis

63

Research Grants for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

RESEARCH GRANTS NIH AWARDS

Mary Elizabeth Hartnett, MD

Alessandra Angelucci, MD, PhD Parallel Pathways in Visual Cortex: Functional Connectivity of Output Pathways from Area V1 to Area V2

$394,976

Endothelial Transmigration in Neovascular Age-Related Macular Degeneration

$381,250

Medical Student Research Program in Eye Health and Disease

$25,473

$378,125

Anatomical and Functional Organization of Inter-Areal Feedback Circuits in the Visual Cortex, and Their Impact on Neuronal Responses

$389,942

Role of Top-Down Feedback in Visual Perception

$106,064

Wolfgang B. Baehr, PhD

Bryan W. Jones, PhD Retinal Remodeling

$399,904

Retinal Circuitry

$726,748

David Krizaj, PhD

Photoreceptor Ciliopathies: Unc119 Paralogs and Nphp10/Nphp5

$372,500

Core Vision Research Grant

$707,139

Vision Research Training Grant

$155,277

Molecular Mechanisms of Mechanotransduction in the Aqueous Outflow Pathway

$381,250

Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects $228,750

$381,250

Neda Nategh, PhD Extrastriate Mechanisms of Visuospatial Perception During Eye Movements

Paul S. Bernstein, MD, PhD Biochemistry & Pharmacology of the Macular Carotenoids

Mechanisms of Angiogenesis in ROP

$381,250

Behrad Noudoost, MD, PhD Understanding the Prefrontal Mechanisms Involved in the Enhancement and Maintenance of Visual Signals

$380,000

Sensory Recruitment by Working Memory: Neuronal Basis and Neural Circuitry

$350,750

Understanding the Neural Basis for Recruitment of Visual Areas by Working Memory

$190,625

Research Grants for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

RESEARCH GRANTS Frans Vinberg, PhD

Mary Elizabeth Hartnett, MD

Assessment of Retinal Function in Health and Disease from Mouse to Human

Knights Templar

$63,226

$240,537

Bryan W. Jones, PhD Research to Prevent Blindness

Jun Yang, PhD Function of C8ORF37 In Photoreceptors Understanding the Functions of USH2A and ADGRV1 in Photoreceptors by Identifying Their Interacting Proteins

$75,000

$581,250

Eileen Hwang, MD, PhD Thrasher Research Foundation

$13,571

$228,750

Randall J Olson, MD

OTHER FEDER AL AWARDS

Research to Prevent Blindness

Alessandra Angelucci, MD, PhD

Frans Vinberg, PhD

$115,000

International Retinal Research Foundation

$99,750

Research to Prevent Blindness

$75,000

F O U N DAT I O N AWA R D S

Diabetes Research Connection

$60,000

Wolfgang B. Baehr, PhD

Jun Yang, PhD

National Science Foundation— Optogenetic Investigation

$100,000

Knights Templar

$65,000

Retina Research Foundation

$33,000

Paul S. Bernstein, MD, PhD Lowy Medical Research Institute

$270,317

Knights Templar

$65,000

Foundation Fighting Blindness

$100,000

International Retinal Research Foundation

$100,000

Published Research for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

PUBLISHED RESEARCH A sample of more than 175 published materials by Moran faculty in Fiscal Year 2020.

Advances in Experimental Medicine and Biology Pfeiffer RL, Anderson JR, Emrich DP, Dahal J, Sigulinsky CL, Morrison HAB, Yang JH, Watt CB, Rapp KD, Kondo M, Terasaki H, Garcia JC, Marc RE, Jones BW. Pathoconnectome Analysis of Müller Cells in Early Retinal Remodeling.

Adv Exp Med Biol. 2019;1185:365-370.

Zou J, Li R, Wang Z, Yang J. Studies of the Periciliary Membrane Complex in the Syrian Hamster Photoreceptor. Adv Exp Med Biol.

2019;1185:543-547.

American Journal of Ophthalmology Sibony PA, Biousse V, Bursztyn L, Costello F, Digre K, Fraser JA, Fraser CL, Huna-Baron R, Katz B, Lawlor M, Malmqvist L, Newman NJ, Peragallo J, Petzold A, Subramanian PS, Warner J, Wegener M, Wong S, Hamann S; ODDS Consortium. Comment on: Morphologic Features of Buried Optic Disc Drusen on En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography. Am J Ophthalmol.

2020 Nov;219:369-370.

Hartnett ME. Retinopathy of Prematurity: Evolving Treatment with Anti-Vascular Endothelial Growth Factor. Am J Ophthalmol.

2020 Oct;218:208-213.

Hamann S, Malmqvist L, Wegener M, Fard MA, Biousse V, Bursztyn L, Citirak G, Costello F, Crum AV, Digre K, Fraser JA, Huna-Baron R, Katz B, Lawlor M, Newman NJ, Peragallo JH, Petzold A, Sibony PA, Subramanian PS, Warner J, Wong SH, Fraser CL. Optic Disc Drusen Studies Consortium. Young Adults with Anterior Ischemic Optic Neuropathy: A Multicenter Optic Disc Drusen Study. Am J Ophthalmol. 2020 Sep;217:174-181.

Pfau M, von der Emde L, Dysli C, Möller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S. Determinants of Cone and Rod Functions in Geographic Atrophy: AI-Based Structure-Function Correlation. Am J Ophthalmol. 2020 Sep;217:162-173.

Tong J, Phu J, Khuu SK, Yoshioka N, Choi AY, Nivison-Smith L, Marc RE, Jones BW, Pfeiffer RL, Kalloniatis M, Zangerl B. Development of a Spatial Model of Age-Related Change in the Macular Ganglion Cell Layer to Predict Function from Structural Changes. Am J Ophthalmol.

2019 Dec;208:166-177.

American Journal of Physiology-Cell Physiology Shahidullah M, Mandal A, Mathias RT, Gao J, Križaj D, Redmon S, Delamere NA. TRPV1 Activation Stimulates NKCC1 and Increases Hydrostatic Pressure in the Mouse Lens. Am J Physiol Cell Physiol. 2020 May 1;318(5):C969-C980.

Bretz CA, Simmons AB, Kunz E, Ramshekar A, Kennedy C, Cardenas I, Hartnett ME. Erythropoietin Receptor Signaling Supports Retinal Function after Vascular Injury. Am J Pathol. 2020 Mar;190(3):630-641.

Annual Review of Nutrition Sauer L, Li B, Bernstein PS. Ocular Carotenoid Status in Health and Disease. Annu Rev Nutr.

2019 Aug 21;39:95-120.

Biochemical Journal Frederick J, Hanke-Gogokhia C, Ying G, Baehr W. Diffuse or Hitch a Ride: How Photoreceptor Lipidated Proteins get from Here to There.

Biol Chem. 2020 Apr 28;401(5):573-584.

Biochimica et Biophysica Acta — Molecular and Cell Biology of Lipids Arunkumar R, Gorusupudi A, Bernstein PS. The Macular Carotenoids: A Biochemical Overview.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158617.

bioRxiv Young B, Ramakrishnan C, Ganjawala T, Li Y, Kim S, Wang P, Chen R, Deisseroth K, Tian N. A Unique and Evolutionarily Conserved Retinal Interneuron Relays Rod and Cone Input to the Inner Plexiform Layer. bioRxiv. 2020 May.

BMC Ophthalmology Conrady CD, Feist RM Jr, Vitale AT, Shakoor A. Long-Term Visual Outcomes of Endophthalmitis and the Role of Systemic

21

Steroids in Addition to Intravitreal Dexamethasone. BMC Ophthalmol. 2020 May 6;20(1):181.

Rai BB, Morley MG, Bernstein PS, Maddess T. Pattern of Vitreo-Retinal Diseases at the National Referral Hospital in Bhutan: A Retrospective, Hospital-Based Study. BMC Ophthalmol. 2020 Feb 13;20(1):51.

BMJ Open Ophthalmology Patel BCK. Management of IgG4-Related Orbital Disease: When Not in Doubt, Cut it Out? BMJ Open Ophthalmol. 2019 Oct 18;4(1):e000401.

Canadian Journal of Ophthalmology Nakatsuka AS, Lin A. Ocular Management of Acute Stevens-Johnson Syndrome in a 14-Month-Old Child. Can J Ophthalmol. 2020 Jun 24:S0008-4182(20)30603-7.

Kabbara SW, Heczko J, Ta B, Bernhisel A, Barlow W, Zaugg B, Olson RJ, Pettey J. Impact of Torsional Micropulse on Phacoemulsification Efficiency and Chatter. Can J Ophthalmol. 2019 Oct;54(5):560-564.

Case Reports Ophthalmology Berkowitz E, River Y, Digre K, Tiosano B, Kesler A. Visual Snow: A Case Series from Israel. Case Rep Ophthalmol. 2020 Jun 9;11(2):205-211.

Cell Death & Differentiation Hutto RA, Bisbach CM, Abbas F, Brock DC, Cleghorn WM, Parker ED, Bauer BH, Ge W, Vinberg F, Hurley JB, Brockerhoff SE. Increasing Ca(2+) in Photoreceptor Mitochondria Alters Metabolites, Accelerates Photoresponse Recovery, and Reveals Adaptations to Mitochondrial Stress. Cell Death Differ. 2020 Mar;27(3):1067-1085.

Cells Yang N, Young BK, Wang P, Tian N. The Susceptibility of Retinal Ganglion Cells to Optic Nerve Injury is Type Specific. Cells. 2020 Mar 10;9(3):677.

Published Research for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R Cerebral Cortex Vanni S, Hokkanen H, Werner F, Angelucci A. Anatomy and Physiology of Macaque Visual Cortical Areas V1, V2, and V5/ MT: Bases for Biologically Realistic Models. Cerebral Cortex, Volume 30, Issue 6. June 2020, Pages 3483–3517.

Current Topics in Behavioral Neurosciences Bahmani Z, Clark K, Merrikhi Y, Mueller A, Pettine W, Isabel Vanegas M, Moore T, Noudoost B. Prefrontal Contributions to Attention and Working Memory. Curr Top Behav Neurosci. 2019;41:129-153.

Channels

Development

Yarishkin O, Baumann JM, Krizaj D. MechanoElectrical Transduction in Trabecular Meshwork Involves Parallel Activation of TRPV4 and TREK-1 Channels. Channels (Austin).

2019 Dec;13(1):168-171.

Bryan CD, Casey MA, Pfeiffer RL, Jones BW, Kwan KM. Optic Cup Morphogenesis Requires Neural Crest-Mediated Basement Membrane Assembly. Development. 2020 Feb 21;147(4):dev181420.

Clinical Neurophysiology

European Journal of Ophthalmology

Ayton LN, Barnes N, Dagnelie G, Fujikado T, Goetz G, Hornig R, Jones BW, Muqit MMK, Rathbun DL, Stingl K, Weiland JD, Petoe MA. An Update on Retinal Prostheses. Clin Neurophysiol. 2020 Jun;131(6):1383-1398.

Clinical Ophthalmology Ripa M, Betts B, Dhaliwal S, Wang K, Pouly S, Chen D, Mifflin M. Survey of Postoperative Pain in Photorefractive Keratectomy Using Topical versus Oral Nonsteroidal Anti-Inflammatory Drugs. Clin Ophthalmol. 2020 May 27;14:14591466.

Computational and Structural Biotechnology Journal Yu D, Zou J, Chen Q, Zhu T, Sui R, Yang J. Structural Modeling, Mutation Analysis, and In Vitro Expression of Usherin, a Major Protein in Inherited Retinal Degeneration and Hearing Loss. Comput Struct Biotechnol J. 2020 Jun 10;18:1363-1382.

Current Eye Research Dalvin LA, Hartnett ME, Bretz CA, Hann CR, Cui RZ, Marmorstein AD, Sheikh-Hamad D, Fautsch MP, Roddy GW. Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity. Curr Eye Res. 2020 Jan;45(1):46-51.

Current Opinion in Ophthalmology Bernhisel A, Pettey J. Manual Small Incision Cataract Surgery. Curr Opin Ophthalmol. 2020 Jan;31(1):74-79.

Current Practices in Ophthalmology Conrady C, Hassman L, Shakoor A. Surgery in Uveitis. Current Practices in Ophthalmology.

2020 Nov. Springer, Singapore.

Costa JF, Bompastor-Ramos P, Marques M, Henriques J, Póvoa J, Lobo C, Alió JL, Werner L, Murta J. Large-Scale Opacification of a Hydrophilic/Hydrophobic Intraocular Lens.

Eur J Ophthalmol. 2020 Mar;30(2):307-314.

Exploration of Medicine Carroll L, Owen L. Current Evidence and Outcomes for Retinopathy of Prematurity Prevention: Insight into Novel Maternal and Placental Contributions. Explor Med. 2020;1:4-26.

Eye Rajamani M, Ramamurthy C, Ramamurthy S, Chaya C, Puthuran G, Kumar S, Nayaka A. Outcome of a Low-Cost Glaucoma Drainage Device with Posterior Chamber/Pars Plana Insertion of the Tube. Eye (Lond). 2020 May 28.

Fluorescence Lifetime Ophthalmoscopy Miura Y, Bernstein PS, Dysli C, Sauer L, Zinkernagel M. Fluorophores in the Eye. Fluorescence Lifetime Ophthalmoscopy. 2019 July. Springer, Cham.

Frontiers in Neurology Olds JJ, Hills WL, Warner J, Falardeau J, Alasantro LH, Moster ML, Egan RA, Cornblath WT, Lee AG, Frishberg BM, Turbin RE, Katz DM, Charley JA, Pelak VS. Posterior Cortical Atrophy: Characteristics from a Clinical Data Registry.

Front Neurol. 2020 Jun 3;11:358.

Genetics in Medicine Williams LB, Javed A, Sabri A, Morgan DJ, Huff CD, Grigg JR, Heng XT, Khng AJ, Hollink IHIM, Morrison MA, Owen LA, Anderson K, Kinard K, Greenlees R, Novacic D, Nida Sen H, Zein WM, Rodgers GM, Vitale AT, Haider NB, Hillmer AM, Ng PC, Shankaracharya, Cheng A, Zheng L, Gillies MC, van Slegtenhorst M, van Hagen PM, Missotten TOAR, Farley GL, Polo M, Malatack J, Curtin J, Martin F, Arbuckle S,

Alexander SI, Chircop M, Davila S, Digre K, Jamieson RV, DeAngelis MM. ALPK1 Missense Pathogenic Variant in Five Families Leads to ROSAH Syndrome, an Ocular Multisystem Autosomal Dominant Disorder. Genet Med. 2019 Sep;21(9):2103-2115.

Headache Ozudogru S, Neufeld A, Katz B, Baggaley S, Pippitt K, Zhang Y, Digre K. Reduced Visual Quality of Life Associated with Migraine is Most Closely Correlated with Symptoms of Dry Eye. Headache. 2019 Nov;59(10):1714-1721.

High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics Bernstein PS, Dysli C, Fischer J, Hammer M, Katayama Y, Sauer L, Zinkernagel MS. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). In J. F. Bille (Ed.), High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics. (pp. 213–235). Springer.

Hypertension in Pregnancy Curtin K, Theilen LH, Fraser A, Smith KR, Varner MW, Hageman GS. Hypertensive Disorders of Pregnancy Increase the Risk of Developing Neovascular Age-Related Macular Degeneration in Later Life. Hypertens Pregnancy. 2019 Aug;38(3):141-148.

Investigative Ophthalmology & Visual Science Deng WT, Li J, Zhu P, Freedman B, Smith WC, Baehr W, Hauswirth WW. Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):36443651.

Rochfort KD, Carroll LS, Barabas P, Curtis TM, Ambati BK, Barron N, Cummins PM. COMPAng1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):35473555.

Sauer L, Komanski CB, Vitale AS, Hansen ED, Bernstein PS. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Eyes with Pigment Epithelial Detachments Due to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3054-3063.

Ranganathan A, Gorusupudi A, Li B, Blount D, Chang F, Bernstein PS. Zeaxanthin Effectively Reduces A2E and Iso-A2E Formation in the Retinal Pigment Epithelium of ABCA4 (- / -)/ BCO2 (- / -) Double KO Mice. Invest. Ophthalmol.

Vis. Sci. 2020;61(7):1509.

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JOHN A . MOR A N E Y E CE N T E R

Murri M, Shah A, Jacobson B, McFadden M, Alsamarae A, Alonzo B, Shakoor A, Pettey J. Prevalence of Glaucoma in an East African Population in Mwanza, Tanzania. Invest.

Ophthalmol. Vis. Sci. 2020;61(7):70.

Sauer L, Vitale A, Modersitzki N, Bernstein PS. Changes in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) over time in patients with Macular Telangiectasia Type 2 (MacTel).

Invest. Ophthalmol. Vis. Sci. 2020;61(7):4328.

Sauer L, Vitale A, Modersitzki N, Bernstein PS. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Patients with Diabetes and Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1852.

Jacobsen B, Zouache M, DeAngelis M, Bernstein PS. A Multi-Generational Family Affected

by Cavitary Optic Disc Anomaly. Invest.

Ophthalmol. Vis. Sci. 2020;61(7):2696.

Gross A, Boitet E, Reish N, Benefield D, Ying G, Wolfgang B, Rowe, G, Hubbard M. NUDC is Critical for Regulation of Photoreceptor Cytoskeletal Network. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1121.

Vitale A, Sauer L, Bernstein PS. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Patients with Choroideremia. Invest.

Ophthalmol. Vis. Sci. 2020; 61(7):3052.

Bernhisel A, Hekzco J, Stagg B, Pettey J, Vitale A. Comparing Eye Care at a Tertiary Eye Care Clinic to a Free Homeless Clinic. Invest. Ophthalmol.

Vis. Sci. 2019; 60(9):4460.

Bernstein PS, Calvo C, Henrie N, Vitale A, Miliken C, Sauer L. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Shows Early Toxicity of Hydroxychloroquine. Invest. Ophthalmol. Vis. Sci. 2019; 60(9):1576.

Krizaj D, Toft-Bertelsen L, Goruspudi A, Macaulay N, Bernstein PS, Lakk M. Cholesterol Regulates TRPV4-Dependent Signaling in the Trabecular Meshwork. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):3424.

Owen L, Hicks P, Morgan D, Ahn J, Silvestri G, Miller J, Park K, Kotoula M, Kim I, Farrer L, Haider N, DeAngelis M. HTRA1 Gene Interaction Network Informs Age-Related Macular Degeneration (AMD) Risk. Invest. Ophthalmol.

Vis. Sci. 2019; 60(9):4895.

Lapajne L, Lakk M, Yarishkin O, Gubeljak L, Hawllina M, Krizaj D. Polymodal Sensory Transduction in Mouse Corneal Epithelial Cells.

Invest. Ophthalmol. Vis. Sci. 2020; 61(4):2.

Reed M, Takemaru K, Baehr W. Retina-and Rod-Specific Knockout of Centrosomal Protein

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Published Research for Fiscal Year 2020 CEP164. Invest. Ophthalmol. Vis. Sci. June 2020, Vol.61, 3779.

Modersitzki N, Sauer L, Vitale A, Milliken C, Bernstein PS. The Impact of Cataracts on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). Invest. Ophthalmol. Vis. Sci. 2020;61(7):5281.

Bretz C, Kunz E, Hartnett ME. E-selectin is Associated with the Development of Neovascularization in the Rat Model of Oxygen Induced Retinopathy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5410.

Deng WT, Zhu P, Dahl T, Baehr W, Hauswirth W. Rescue of Cone Structure and Function in Opn1mw/sw Double Knockout Mice. Invest.

Ophthalmol. Vis. Sci. 2020; 61(7):2456.

Cheng X, Liang Q, Owen L, Shakoor A, Vitale A, Kim I, Morgan D, Li Y, DeAngelis M, Chen R. Single-Nuclei RNA-Seq Provides Comprehensive Transcriptomic Classification of Human Retinal Cell Types. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1956.

Gregerson C, Annis T, Murri M, Shumway C, Pettey J, Shah A. Usability of a Portable Virtual Reality Device for Visual Field Screening in Outreach Settings. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):3892.

Ramshekar A, Bretz C, Hartnett ME. RNA-Seq Analysis of VEGF-Induced STAT3 in Human Retinal Microvascular Cells. Invest. Ophthalmol.

Vis. Sci. 2020; 61(7):5412.

Pfau M, Alexander von der Emde L, Sisternes L, Hallak J, Leng T, Schmitz-Valckenberg S, Holz F, Fleckenstein M, Rubin D. Multilayer Atrophy Progression in Eyes with Geographic Atrophy Secondary to Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):1839.

Hicks P, Haaland B, Feehan M, Crandall A, Pettey J, Vitale A, Hartnett ME, Bernstein PS, Shakoor A, Sieminski S, Shulman J, Kim I, Own L, Murtaugh M, Noyes A, De Angelis M. Retinal and Systemic Disease of Native Americans in the Intermountain West. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):3340.

Li B, Chang F, Gorusupudi A, Ranaganathan A, Rognon G, Shi L, Blout D, Frederick J, Bernstein PS. High-Density Lipoprotein (HDL) Can Transport Carotenoids to the Mouse Retina.

Invest. Ophthalmol. Vis. Sci. 2020; 61(7):1123.

Hartnett ME, Sauer L, Vitale A, Modersitzki N, Bernstein PS. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Patients with Stargardt and Stargardt-Like Macular Dystrophies. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):5282.

Stagg B, Mariottoni E, Berchuck S, Jammal A, Hess R, Kawamoto K, Haaland B, Medeiros F. The Association Between Race and Longitudinal Visual Field Variability. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):4045.

Birch D, Bernstein PS, MacDonald I, Stout T, Liao D, Locke K, Zhai Y, Miller A, Holt J, Leung A, Honarmand S, Jorda P, Luhmann U, Kirn D, Francis P. The Natural History of Choroideremia; Progressive Loss of Visual Function and Retinal Structure. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):1908.

Rohrer B, Nicholson C, Annamalai B, Stephenson S, Atkinson C, Jones BW. Induction of Antibodies Against Oxidized Elastin Exacerbates Structural and Functional Damage in Mouse Models of Age-Related Macular Degeneration. Invest.

Ophthalmol. Vis. Sci. 2020; 61(7):1115.

Abbas F, Becker S, Jones BW, Hanneken A, Vinberg F. Restoration of Light-Evoked Electrical Signals in the Postmortem Mouse and Human Retina. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):3987.

Pham N, Leinonen H, Boyd T, Santoso J, Palczewski K, Vinberg F. Maintained Scotopic Contrast Sensitivity is Associated with Increased Rod-to-Rod Bipolar Cell Signal Transmission in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):4513.

Becker S, Vinberg F. Diabetes Does Not Irreversibly Impair Photoreceptor and ONBipolar Cell Function. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):3993.

Schmitz-Valckenberg S, Braun M, Thiele S, Gao S, Chen H, Steffen V, Dai J, Honigberg L, Ferrar D, Holz F, Sassmannshausen M. Development of Geographic Atrophy Assessed by Multimodal Imaging in Intermediate Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):2353.

Hwang E, Kraker J, Koller E. Progression of Partial Posterior Vitreous Detachment Over Time. Invest. Ophthalmol. Vis. Sci. 2020; 61(7):4821.

Künzel SH, Möller PT, Lindner M, Goerdt L, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M, Pfau M. Determinants of Quality of Life in Geographic Atrophy Secondary to Age- Related Macular Degeneration. Invest.

Ophthalmol. Vis. Sci. 2020 May 11;61(5):63.

JOHN A . MOR A N E Y E CE N T E R JAMA Oncology Global Retinoblastoma Study Group, Hartnett ME, et al. Global Retinoblastoma Presentation and Analysis by National Income Level. JAMA Oncol. 2020 May 1;6(5):685-695.

JAMA Ophthalmology Wallace DK, Kraker RT, Freedman SF, Crouch ER, Bhatt AR, Hartnett ME, Yang MB, Rogers DL, Hutchinson AK, VanderVeen DK, Haider KM, Siatkowski RM, Dean TW, Beck RW, Repka MX, Smith LE, Good WV, Kong L, Cotter SA, Holmes JM; Pediatric Eye Disease Investigator Group (PEDIG). Short-term Outcomes after Very Low-Dose Intravitreous Bevacizumab for Retinopathy of Prematurity. JAMA Ophthalmol.

2020 Jun 1;138(6):698-701.

Bernstein PS. Does Dark Chocolate Enhance Visual Function? JAMA Ophthalmol. 2019 Sep 26.

Strauss RW, Kong X, Ho A, Jha A, West S, Ip M, Bernstein PS, Birch DG, Cideciyan AV, Michaelides M, Sahel JA, Sunness JS, Traboulsi EI, Zrenner E, Pitetta S, Jenkins D, Hariri AH, Sadda S, Scholl HPN; ProgStar Study Group. Progression of Stargardt Disease as Determined by Fundus Autofluorescence over a 12-Month Period: ProgStar Report No. 11. JAMA Ophthalmol. 2019 Aug 1;137(10):1134-45.

Gong D, Winn BJ, Beal CJ, Blomquist PH, Chen RW, Culican SM, Dagi Glass LR, Domeracki GF, Goshe JM, Jones JK, Khouri AS, Legault GL, Martin TJ, Mitchell KT, Naseri A, Oetting TA, Olson JH, Pettey JH, Reinoso MA, Reynolds AL, Siatkowski RM, SooHoo JR, Sun G, Syed MF, Tao JP, Taravati P, WuDunn D, Al-Aswad LA. Gender Differences in Case Volume Among Ophthalmology Residents. JAMA Ophthalmol.

2019 Jul 18;137(9):1015-20.

Japanese Journal of Ophthalmology Obana A, Gohto Y, Sasano H, Gellermann W, Sharifzadeh M, Seto T, Bernstein PS. Spatial Distribution of Macular Pigment Estimated

by Autofluorescence Imaging in Elderly Japanese Individuals. Jpn J Ophthalmol. 2020 Mar;64(2):160-170.

Journal of Biological Chemistry Toft-Bertelsen TL, Yarishkin O, Redmon S, Phuong TTT, Krizaj D, MacAulay N. Volume Sensing in the Transient Receptor Potential Vanilloid 4 Ion Channel is Cell Type-Specific and Mediated by an N-Terminal VolumeSensing Domain. J Biol Chem. 2019 Nov 29;294(48):18421-18434.

Published Research for Fiscal Year 2020 Journal of Cataract & Refractive Surgery Trindade BLC, Trindade FC, Werner L, Trindade CLC. Long-Term Safety of In-The-Bag Implantation of a Supplementary Intraocular Pinhole. J Cataract Refract Surg. 2020 Jun;46(6):888-892.

Bohner A, Peterson JS, Wright AJ, Mamalis C, Bernhisel A, Zaugg B, Barlow WR Jr, Olson RJ, Pettey JH. Effects on Phacoemulsification Efficiency and Chatter at Variable Longitudinal Ultrasound Settings when Combined with Constant Torsional Energy. J Cataract Refract Surg. 2020 May;46(5):774-777.

Balendiran V, Werner L, Ellis N, Shumway C, Jiang B, Kamae K, Mamalis N. Uveal and Capsular Biocompatibility of a New Hydrophobic Acrylic Microincision Intraocular Lens. J Cataract Refract Surg. 2020 Mar;46(3):459-464.

Sorenson AL, Holland S, Tran K, Evans DJ, Lin MC, Mamalis N, Chang DF. Diffuse Lamellar Keratitis Associated with Tabletop Autoclave Biofilms: Case Series and Review. J Cataract Refract Surg.

2020 Mar;46(3):340-349.

Ellis N, Werner L, Balendiran V, Shumway C, Jiang B, Mamalis N. Posterior Capsule Opacification Prevention by An Intraocular Lens Incorporating a Micropatterned Membrane on the Posterior Surface. J Cataract Refract Surg. 2020 Jan;46(1):102-107.

Filipe HP, Bozukova D, Pimenta A, Vieira AP, Oliveira AS, Galante R, Topete A, Masson M, Alves P, Coimbra P, Gil MH, Guiomar AJ, Mata J, Colaço R, Saramago B, Werner L, Mamalis N, Serro AP. Moxifloxacin-Loaded Acrylic Intraocular Lenses: In Vitro and In Vivo Performance. J Cataract Refract Surg. 2019 Dec;45(12):1808-1817.

Balendiran V, MacLean K, Mamalis N, Tetz M, Werner L. Localized Calcification of Hydrophilic Acrylic Intraocular Lenses after Posterior Segment Procedures. J Cataract Refract Surg.

2019 Dec;45(12):1801-1807.

Bernhisel AA, Cahoon JM, Sella R, Zaugg B, Barlow WR, Stagg B, Afshari NA, Olson RJ, Pettey JH. Optimum On-Time and Off-Time Combinations for Micropulse Phacoemulsification in Venturi Vacuum Mode.

J Cataract Refract Surg. 2019 Dec;45(12): 1797-1800.

Shumway C, Ellis N, Heczko J, Jiang B, Werner L, Mamalis N. Evaluation of the Capsular Safety of a New Hybrid Phacoemulsification Tip in a Cadaver Eye Model. J Cataract Refract Surg. 2019 Nov;45(11):1660-1664.

MA. Evaluation of Clarity Characteristics in a New Hydrophobic Acrylic IOL in Comparison to Commercially Available IOLs. J Cataract Refract Surg. 2019 Oct;45(10):1490-1497.

Werner L, Wallace JK, Balendiran V, Shumway C, Ellis N, Mamalis N. Surface Deposits Mimicking Calcification on a Hydrophobic Acrylic Intraocular Lens. J Cataract Refract Surg. 2019 Jul;45(7):1036-1039.

Kohnen T, Mamalis N, Dupps WJ Jr, Srinivasan S. Lots of New This Year. J Cataract Refract Surg.

2020 Jan;46(1):1.

Journal of Cataract & Refractive Surgery Case Reports Larochelle M, Werner L. Explantation of a Glistening-Free, Hydrophobic Acrylic Intraocular Lens with Cosmetic Imperfections on the Lens Surface. J Cataract Refract Surg Online Case Reports. 2020 April, 8(2):e00011.

Journal of Glaucoma Mathew S, Harris A, Ridenour CM, Wirostko B, Burgett KM, Scripture MD, Siesky B. Response to: Management of Glaucoma in Pregnancy. J Glaucoma. 2020 Apr;29(4):e27.

Mathew S, Harris A, Ridenour CM, Wirostko B, Burgett KM, Scripture MD, Siesky B. Response.

J Glaucoma. 2020 Jan 27.

Mathew S, Harris A, Ridenour CM, Wirostko B, Burgett KM, Scripture MD, Siesky B. Management of Glaucoma in Pregnancy. J Glaucoma. 2019 Oct;28(10):937-944.

Journal of Neuro-Ophthalmology Patel RC, Vitale AT, Creel DJ, Digre K. Not All That Flickers is Snow. J Neuroophthalmol. 2020 Mar 24.

Seay M. American Academy of Ophthalmology and Neuro-Ophthalmology Subspecialty Day 2019 Summary. J Neuroophthalmol. 2020 Mar;40(1):e1-e2.

Seay M, Digre K. The 45th Annual Meeting of the North American Neuro-Ophthalmology Society in Las Vegas, Nevada.

J Neuroophthalmol. 2019 Sep;39(3):e10-e12.

Seay M, Fortin E, Digre K. Great Conversations: Dr. Barrett Katz. J Neuroophthalmol. 2019 Sep;39(3):e13-e14.

Journal of Neuroscience Yarch J, Larsen H, Chen M, Angelucci A. Morphological Cell Types Projecting from V1 Layer 4B to V2 Thick and Thin Stripes. J Neurosci.

2019 Sep 18;39(38):7501-7512.

Werner L, Thatthamla I, Ong M, Schatz H, GarciaGonzalez M, Gros-Otero J, Cañones-Zafra R, Teus

24

Published Research for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R Journal of Ocular Pharmacology and Therapeutics

Neurology Neuroimmunology & Neuroinflammation

Wirostko B, Mann B, Stirland D. Re: “CrossLinked Hyaluronic Acid as Tear Film Substitute”

by Posarelli et al. (J Ocul Pharmacol Ther 2019;35(7):381-387). J Ocul Pharmacol Ther. 2020 May;36(4):205.

Piquet AL, Khan M, Warner J, Wicklund MP, Bennett JL, Leehey MA, Seeberger L, Schreiner TL, Paz Soldan MM, Clardy SL. Novel Clinical Features of Glycine Receptor Antibody Syndrome: A Series of 17 Cases. Neurol Neuroimmunol Neuroinflamm. 2019 Jul 1;6(5):e592.

Perez VL, Wirostko B, Korenfeld M, From S, Raizman M. Ophthalmic Drug Delivery Using Iontophoresis: Recent Clinical Applications.

J Ocul Pharmacol Ther. 2020 Mar;36(2):75-87.

Kuppermann BD, Bernstein PS, Mones J, Do DV, Neumann R, Rosenfeld PJ. ISOPT Clinical Hot Topic Panel Discussion on Medical Treatment of Retinal Diseases. J Ocul Pharmacol Ther. 2019 Oct;35(8):424-432.

Journal of Visualized Experiments Vanegas MI, Hubbard KR, Esfandyarpour R, Noudoost B. Microinjectrode System for Combined Drug Infusion and Electrophysiology.

J Vis Exp. 2019 Nov 13;(153):10.3791/60365.

Klinische Monatsblätter für Augenheilkunde Fleckenstein M, Thiele S, Pfau M, SchmitzValckenberg S, Holz FG. Dry Age-Related Macular Degeneration—Epidemiology and Classification. Klin Monbl Augenheilkd. 2019 Sep;236(9):1068-1075.

Neuroscience

Ocular Immunology and Inflammation

Ophthalmologe

Kutluturk I, Agarwal A, Shulman S, Vitale A, Parodi MB, Conrady CD, Hurtikova K, Cunha Souza E, Rodriguez EC, Chhablani J, Tappeiner C, Gerding H, Zinkernagel MS, Tucker W, Munk MR. The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies. Ocul Immunol Inflamm. 2020 Feb 20:1-8.

Schmitz-Valckenberg S, Brasse K, Hoerauf H. Vitreous Floaters. Ophthalmologe. 2020 May;117(5):485-496.

Rifkin LM, Vadboncoeur J, Minkus CC, Dunn EN, Moorthy RS, Bhatt N, Sen HN, Taggart MG, Vitale AT, Goldstein DA. The Utility of Lyme Testing in the Workup of Ocular Inflammation. Ocul Immunol Inflamm. 2019 Oct 2:1-5.

Moshirfar M, Buckner B, Rosen DB, Heiland MB, Ronquillo YC, Skanchy DF, Liu HY, Melton T, Werner L, Hoopes PCJ. Visual Prognosis after Explantation of a Corneal Shape-Changing Hydrogel Inlay in Presbyopic Eyes. Med Hypothesis Discov Innov Ophthalmol. 2019 Fall;8(3):139-144.

Kutluturk I, Agarwal A, Shulman S, Vitale A, Parodi MB, Conrady CD, Hurtikova K, Cunha Souza E, Rodriguez EC, Chhablani J, Tappeiner C, Gerding H, Zinkernagel MS, Tucker W, Munk MR. The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies. Ocul Immunol Inflamm. 2020 Feb 20:1-8.

Molecular Nutrition & Food Research

Rifkin LM, Vadboncoeur J, Minkus CC, Dunn EN, Moorthy RS, Bhatt N, Sen HN, Taggart MG, Vitale AT, Goldstein DA. The Utility of Lyme Testing in the Workup of Ocular Inflammation.

Ocul Immunol Inflamm. 2019 Oct 2:1-5.

Liang Q, Dharmat R, Owen L, Shakoor A, Li Y, Kim S, Vitale A, Kim I, Morgan D, Liang S, Wu N, Chen K, DeAngelis M, Chen R. Single-Nuclei RNA-Seq on Human Retinal Tissue Provides Improved Transcriptome Profiling. Nat Commun. 2019 Dec 17;10(1):5743.

25

Ophthalmic Surgery, Lasers and Imaging Retina Jacobsen B, Shah A, Aggarwal S, Mwanansao C, McFadden M, Zouache M, Shakoor A. Prevalence of Retinal Diseases and Associated Risk Factors in an African Population from Mwanza, Tanzania. Ophthalmic Surg Lasers Imaging Retina.

2020 May 1;51(5):S17-S25.

Medical Hypothesis, Discovery & Innovation in Ophthalmology

Nature Communications

Suwal B, Bajimaya S, Bernstein PS. Bietti’s Crystalline Dystrophy in Nepalese Patients: When Genetic Analysis Supports Clinical Diagnosis. Ophthalmic Genet. 2019 Aug;40(4):390-392.

Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 Sep 15;416:100-108.

Conrady CD, Shakoor A. Rituximab-Associated Retinal Occlusive Vasculopathy: A Case Report and Literature Review. Ocul Immunol Inflamm.

2020 May 18;28(4):622-625.

Gorusupudi A, Chang FY, Nelson K, Hageman GS, Bernstein PS. n-3 PUFA Supplementation Alters Retinal Very-Long-Chain-PUFA Levels and Ratios in Diabetic Animal Models. Mol Nutr Food Res. 2019 Aug;63(15):e1801058.

Ophthalmic Genetics

Conrady CD, Shakoor A. Rituximab-Associated Retinal Occlusive Vasculopathy: A Case Report and Literature Review. Ocul Immunol Inflamm.

2020 May 18;28(4):622-625.

Merrill PT, Vitale A, Zierhut M, Goto H, Kron M, Song AP, Pathai S, Fortin E. Efficacy of Adalimumab in Non-Infectious Uveitis Across Different Etiologies: A Post Hoc Analysis of the VISUAL I and VISUAL II Trials. Ocul Immunol Inflamm. 2020 May 29:1-7.

Eter N, Pauleikhoff D, Agostini H, Fleckenstein M, Ziemssen F. Value and Formats of Quality Assurance: Ophthalmology and Intravitreal Therapy Between Reality and Wishful Thinking.

Ophthalmologe. 2020 Apr;117(4):298-306.

Schmitz-Valckenberg S, Kühlewein L, Waldstein SM, Spital G, Ziemssen F, Liakopoulos S. Second Opinion in Retinal Imaging. Ophthalmologe. 2020 Apr;117(4):326-330.

Ophthalmologica von der Emde L, Thiele S, Pfau M, Nadal J, Meyer J, Möller PT, Schmid M, Fleckenstein M, Holz FG, Schmitz-Valckenberg S. Assessment of Exudative Activity of Choroidal Neovascularization in Age-Related Macular Degeneration by OCT Angiography. Ophthalmologica. 2020;243(2):120128.

Ophthalmology Werner L. Intraocular Lenses: Overview of Designs, Materials, and Pathophysiologic Features. Ophthalmology. 2020 Jun 30:S01616420(20)30626-6.

Ophthalmology Retina Hamad AE, Moinuddin O, Blair MP, Schechet SA, Shapiro MJ, Quiram PA, Mammo DA, Berrocal AM, Prakhunhungsit S, Cernichiaro-Espinosa LA, Mukai S, Yonekawa Y, Ung C, Holz ER, Harper CA 3rd, Young RC, Besirli CG, Nagiel A, Lee TC, Gupta MP, Walsh MK, Khawly JA, Campbell JP, Kychenthal A, Nudleman ED, Robinson JE, Hartnett ME, Calvo CM, Chang EY. Late-Onset Retinal Findings and Complications in Untreated

Published Research for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

Retinopathy of Prematurity. Ophthalmol Retina.

2020 Jun;4(6):602-612.

Pfau M, Möller PT, Künzel SH, von der Emde L, Lindner M, Thiele S, Dysli C, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M. Type 1 Choroidal Neovascularization Is Associated with Reduced Localized Progression of Atrophy in Age-Related Macular Degeneration. Ophthalmol Retina. 2020 Mar;4(3):238-248.

Sauer L, Calvo CM, Vitale AS, Henrie N, Milliken CM, Bernstein PS. Imaging of Hydroxychloroquine Toxicity with Fluorescence Lifetime Imaging Ophthalmoscopy. Ophthalmol Retina. 2019 Oct;3(10):814-825.

Orbit Bernhisel AA, Zaugg B, Mamalis N, Dutton JJ, Patel BCK. An Unusual Case of Idiopathic Calcinosis of the Eyelid. Orbit. 2019 Dec;38(6):500-502.

Pediatric Neurology Kohli AA, Vossough A, Mallery RM, Woo JH, Sheldon CA, Paley GL, Digre K, Friedman DI, Farrar JT, McCormack SE, Liu GT, Szperka CL. Magnetic Resonance Imaging Findings in Pediatric Pseudotumor Cerebri Syndrome.

Pediatr Neurol. 2019 Oct;99:31-39.

PLOS Computational Biology Niknam K, Akbarian A, Clark K, Zamani Y, Noudoost B, Nategh N. Characterizing and Dissociating Multiple Time-Varying Modulatory Computations Influencing Neuronal Activity.

PLoS Comput Biol. 2019 Sep 12;15(9):e1007275.

Proceedings of the National Academy of Sciences of the United States of America Li B, George EW, Rognon GT, Gorusupudi A, Ranganathan A, Chang FY, Shi L, Frederick JM, Bernstein PS. Imaging Lutein and Zeaxanthin in the Human Retina with Confocal Resonance Raman Microscopy. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12352-12358.

Progress in Retinal and Eye Research

Retina

StatPearls

Sauer L, Vitale AS, Andersen KM, Hart B, Bernstein PS. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Patterns in Clinically Unaffected Children Of Macular Telangiectasia Type 2 (MacTel) Patients. Retina. 2020 Apr;40(4):695-704.

Moshirfar M, Hastings J, Ronquillo Y, Patel BC. Palytoxin Keratitis. StatPearls. 2020 May 4.

Ronquillo CC, Sauer L, Morgan D, Heckzo JB, Creel DJ, Mamalis N, DeAngelis MM, Hagemann GS, Bernstein PS. Absence Of Macular Degeneration in a Patient with Aceruloplasminemia. Retina. 2019 Sep;39(9):1824-1828.

Retinal Cases & Brief Reports Conrady CD, Feistmann JA, Roller AB, Boldt HC, Shakoor A. Hemorrhagic Vasculitis and Retinopathy Heralding as an Early Sign of Bacterial Endophthalmitis after Intravitreal Injection. Retin Cases Brief Rep. 2019 Fall;13(4):329-332.

Choi RY, Shakoor A, Bohnsack J, Vitale AT. Intermediate Uveitis Associated with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome. Retin Cases Brief Rep. 2019 Fall;13(4):367-370.

Choi RY, Jacoby R, Shakoor A. Multimodality Ocular Imaging in a Case Report of Hyperviscosity Syndrome Associated with lymphoplasmacytic Leukemia: The Images Tell the Story. Retin Cases Brief Rep. 2019 Summer;13(3):238-240.

Science Mure LS, Vinberg F, Hanneken A, Panda S. Functional Diversity of Human Intrinsically Photosensitive Retinal Ganglion Cells. Science.

2019 Dec 6;366(6470):1251-1255.

Science Reports Obana A, Gohto Y, Nakazawa R, Moriyama T, Gellermann W, Bernstein PS. Effect of an Antioxidant Supplement Containing High Dose Lutein and Zeaxanthin on Macular Pigment and Skin Carotenoid Levels. Sci Rep. 2020 Jun 24;10(1):10262.

Pfeiffer RL, Marc RE, Jones BW. Persistent Remodeling and Neurodegeneration in LateStage Retinal Degeneration. Prog Retin Eye Res. 2020 Jan;74:100771.

Wang H, Kunz E, Stoddard GJ, Hauswirth WW, Hartnett ME. Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-Driven Active Rap1a in the RPE. Sci Rep. 2019 Oct 31;9(1):15732.

Baehr W, Hanke-Gogokhia C, Sharif A, Reed M, Dahl T, Frederick J, Ying G. Insights into Photoreceptor Ciliogenesis Revealed by Animal Models. Prog Retin Eye Res. 2019 Jul;71:26-56.

Choi AYJ, Nivison-Smith L, Phu J, Zangerl B, Khuu SK, Jones BW, Pfeiffer RL, Marc RE, Kalloniatis M. Contrast Sensitivity Isocontours of the Central Visual Field. Sci Rep. 2019 Aug 12;9(1):11603.

Moshirfar M, Somani SN, Patel BC. Small Incision Lenticule Extraction. StatPearls. 2020 Jun 26.

Somani SN, Moshirfar M, Patel BC. Photorefractive Keratectomy. StatPearls. 2020 Jun 26.

Vegunta S, Patel BC. Optic Nerve Cysts.

StatPearls. 2020 Jun 30.

Vegunta S, Patel BC. Optic Nerve Coloboma.

StatPearls. 2020 Jun 30.

Nehring SM, Goyal A, Bansal P, Patel BC. C Reactive Protein. StatPearls. 2020 Jun 5.

Ronquillo Y, Patel BC. Nonspecific Orbital Inflammation. StatPearls. 2020 Jun 30.

Patel R, Patel BC. Dacryoadenitis. StatPearls.

2020 Jun 23.

Koka K, Patel BC. Capillary Infantile Hemangiomas. StatPearls. 2020 Jun 4.

Patel DR, Patel BC. Ocular Melanoma. StatPearls.

2020 May 24.

Butt S, Patel BC. Exophthalmos. StatPearls. 2020 Jun 30.

Ahmad B, Patel BC. Trachoma. StatPearls. 2020 Jun 4.

Patel J, Levin A, Patel BC. Epiphora Clinical Testing. StatPearls. 2020 May 4.

Huang M, Patel J, Patel BC. Optic Nerve Glioma.

StatPearls. 2020 May 4.

Adesina OO, Patel BC. Optic Nerve Decompression. StatPearls. 2020 Jun 28.

Patel BC, Malhotra R. Cilia Incarnata. StatPearls.

2020 Jun 23.

Kanukollu VM, Patel BC. Herpes Simplex Ophthalmicus. StatPearls. 2020 Jun 21.

Sharma AN, Patel BC. Laser Fitzpatrick Skin Type Recommendations. StatPearls. 2020 May 4.

Shah A, Patel BC. Superior Ophthalmic Vein Cannulation for Carotid Cavernous Fistula.

StatPearls. 2020 May 18.

Raggio BS, Patel BC. Deep Plane Facelift.

StatPearls. 2020 May 13.

Moshirfar M, Milner D, Patel BC. Cataract Surgery. StatPearls. 2020 Jun 26.

Moshirfar M, Hastings J, Ronquillo Y, Patel BC. Keratoendotheliitis Fugax Hereditaria.

StatPearls. 2020 May 4

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JOHN A . MOR A N E Y E CE N T E R Survey of Ophthalmology Boulter T, Bernhisel A, Mamalis C, Zaugg B, Barlow WR, Olson RJ, Pettey JH. Phacoemulsification in Review: Optimization of Cataract Removal in an In Vitro Setting. Surv Ophthalmol. 2019 Nov-Dec;64(6):868-875.

Telemedicine Journal and e-Health Gan K, Liu Y, Stagg B, Rathi S, Pasquale LR, Damji K. Telemedicine for Glaucoma: Guidelines and Recommendations. Telemed J E Health. 2020 Apr;26(4):551-555.

The FASEB Journal Du H, Zou L, Ren R, Li N, Li J, Wang Y, Sun J, Yang J, Xiong W, Xu Z. Lack of PDZD7 Long Isoform Disrupts Ankle-Link Complex and Causes Hearing Loss in Mice. FASEB J. 2020 Jan;34(1):1136-1149.

Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific Modulation of Dimeric Rhodopsin. FASEB J. 2019 Aug;33(8):9526-9539.

Published Research for Fiscal Year 2020 Translational Vision Science & Technology Meyer JH, Marx J, Strack C, Holz FG, SchmitzValckenberg S. Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model. Transl Vis Sci Technol. 2020 Jun 25;9(7):29.

Zhai Y, Xu M, Dimopoulos IS, Birch DG, Bernstein PS, Holt J, Kirn D, Francis P, MacDonald IM. Quantification of RPE Changes in Choroideremia Using a Photoshop-Based Method. Transl Vis Sci Technol. 2020 Jun 18;9(7):21.

Zouache MA, Silvestri G, Amoaku WM, Silvestri V, Hubbard WC, Pappas C, Akafo S, Lartey S, Mastey RR, Carroll J, Hageman GS. Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations. Transl Vis Sci Technol. 2020 Apr 28;9(5):24.

The Journal of Neuroscience

Green-Gomez M, Bernstein PS, Curcio CA, Moran R, Roche W, Nolan JM. Standardizing the Assessment of Macular Pigment Using a DualWavelength Autofluorescence Technique. Transl Vis Sci Technol. 2019 Dec 18;8(6):41.

Sigulinsky CL, Anderson JR, Kerzner E, Rapp CN, Pfeiffer RL, Rodman TM, Emrich DP, Rapp KD, Nelson NT, Lauritzen JS, Meyer M, Marc RE, Jones BW. Network Architecture of Gap Junctional Coupling among Parallel Processing Channels in the Mammalian Retina. J Neurosci.

2020 Jun 3;40(23):4483-4511.

Valiente-Soriano FJ, Ortín-Martínez A, Di Pierdomenico J, García-Ayuso D, Gallego-Ortega A, Miralles de Imperial-Ollero JA, Jiménez-López M, Villegas-Pérez MP, Wheeler L, Vidal-Sanz M. Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity.

Transl Vis Sci Technol. 2019 Dec 16;8(6):36.

The New England Journal of Medicine

Trends in Endocrinology & Metabolism

Gantner ML, Eade K, Wallace M, Handzlik MK, Fallon R, Trombley J, Bonelli R, Giles S, HarkinsPerry S, Heeren TFC, Sauer L, Ideguchi Y, Baldini M, Scheppke L, Dorrell MI, Kitano M, Hart BJ, Cai C, Nagasaki T, Badur MG, Okada M, Woods SM, Egan C, Gillies M, Guymer R, Eichler F, Bahlo M, Fruttiger M, Allikmets R, Bernstein PS, Metallo CM, Friedlander M. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.

N Engl J Med. 2019 Oct 10;381(15):1422-1433.

Pfeiffer RL, Marc RE, Jones BW. Müller Cell Metabolic Signatures: Evolutionary Conservation and Disruption in Disease.

Trends Endocrinol Metab. 2020 Apr;31(4):320-329.

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JOHN A . MOR A N E Y E CE N T E R

Clinical Trials/Studies for Fiscal Year 2020

CLINICAL TRIALS/STUDIES More than 90 clinical research trials and studies are underway at the Moran Eye Center.

CATARACT Clinical Study of the ARTISAN Aphakia Lens for the Correction of Aphakia in Adults PI: Craig J. Chaya, MD

A Phase I/II Randomized, Double-Masked, Placebo-Controlled Study for Determining the Safety of Processed Amniotic Fluid (PAF) Drops after Photorefractive Keratectomy PI: Mark D. Mifflin, MD

Clinical Study of the ARTISAN Aphakia Lens for the Correction of Aphakia in Children PI: Craig J. Chaya, MD

Incidence of Chronic Dry Eye Following Photorefractive Keratectomy and Laser in Situ Keratomileusis PI: Mark D. Mifflin, MD

Expanded Access/Compassionate Use of the Ophtec ARTISAN Aphakia Lens for the Correction of Aphakia PI: Craig J. Chaya, MD

Causes of Death and Co-Morbidities among Individuals with Keratoconus PI: Randall J Olson, MD

Relationship Between Geriatric Patient Age and Refractive Outcomes in Cataract Surgery PI: Jeff Pettey, MD, MBA Survey of Ophthalmology Residency Programs to Determine Training Frequencies of Extracapsular Cataract Surgery and Small Incision Cataract Surgery PI: Jeff Pettey, MD, MBA Pediatric Cataract Surgery Outcomes Registry PI: Marielle Young, MD

CORNEA CIRB: Zoster Eye Disease Study (ZEDS)—A multicenter, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stroma PI: Amy Lin, MD Minimally Invasive Glaucoma Procedures and Corneal Transplants PI: Amy Lin, MD Prevention of Exposure Keratopathy in the Medical Intensive Care Unit PI: Amy Lin, MD INTACS for Treatment of Keratoconic Patients PI: Mark D. Mifflin, MD Survey of Post-Operative Pain in Photorefractive Keratectomy When Using Topical Versus Oral Non-Steroidal Anti-Inflammatory Drugs PI: Mark D. Mifflin, MD Outcomes of Topography-Guided Laser-Assisted in Situ Keratomileusis (LASIK) and Photorefractive Keratectomy (PRK) Compared to Wavefront Optimized LASIK and PRK PI: Mark D. Mifflin, MD

GLAUCOMA Multicenter GATT Retrospective Review PI: Craig J. Chaya, MD Effect of Dermatological Pulsed Dye Laser Therapy on Intraocular Pressure in Children with Facial Port Wine Stains PI: Craig J. Chaya, MD Glaucoma Surgery in Patients with Uveitis PI: Craig J. Chaya, MD Outcomes of Ab-Externo XEN 45 Placement—a New Delivery—in Patients with Glaucoma: EXPAND Study PI: Craig J. Chaya, MD Open-Angle Glaucoma after Vitrectomy: A retrospective review PI: TBA Virtual Reality Functional Testing to Screen for Early-Stage Glaucoma PI: Randall J Olson, MD Pseudoexfoliation and Co-Morbidities PI: Barbara M. Wirostko, MD

NEURO-OPHTHALMOLOGY The Use of Color Duplex Sonography in the Evaluation of Giant Cell Arteritis PI: Alison Crum, MD Identification of Bacteria in Tissue Specimens from Patients with Giant Cell Arteritis PI: Bradley J. Katz, MD, PhD Advanced Imaging Techniques for Better Detection of MLF Lesions Using Multidirection DTI PI: Meagan Seay, DO Outcomes after Acute Central Retinal Artery Occlusion PI: Meagan Seay, DO

JOHN A . MOR A N E Y E CE N T E R

Clinical Trials/Studies for Fiscal Year 2020

Virtual Visual Field Retrospective Analysis PI: Meagan Seay, DO Genetic Initiative in Neuro-Ophthalmic Conditions (GINOC)—Idiopathic Intracranial Hypertension (IIH) PI: Judith E.A. Warner, MD Documenting Sharp Edge Eye Syndrome (SEES): Clinical and phenotype presentations PI: Judith E.A. Warner, MD Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) in Patients Age 50-years or Less PI: Judith E.A. Warner, MD

OCULOPLASTICS Patient Satisfaction in Ocular Related Micrographic and Reconstructive Surgery PI: Douglas Marx, MD

OTHER

The Interest and Needs of Eye Care Providers in Clinical Decision Support PI: Brian C. Stagg, MD Comparison of the Demographic and Ocular Clinical Profile of Homeless and Non-Homeless Patients in Salt Lake City, Utah PI: Albert T. Vitale, MD Reporting Methods, Documentation, and Rates of Intra-Operative Surgery Complications at the John A. Moran Eye Center PI: Judith E.A. Warner, MD

PEDIATRIC OPHTHALMOLOGY Collaborative Retrospective Reviews of Rare Pediatric Ophthalmology Diseases PI: Mary Elizabeth Hartnett, MD Postnatal Growth and Retinopathy of Prematurity Model Development Study G-ROP-1 PI: Robert O. Hoffman, MD

Patterns of Blindness in the Navajo Nation: A Retrospective Study PI: Craig J. Chaya, MD

Growth and Retinopathy of Prematurity Registry (G-ROP Registry) PI: Robert O. Hoffman, MD

Visual Impairment among School-Aged Children in Federated States of Micronesia PI: Craig J. Chaya, MD

Analysis of Genetic Variant and Treatment Based Variations in Infants at Risk for Retinopathy of Prematurity (ROP) PI: Leah Owen, MD, PhD

Evaluation of a Double-Flipped, On-line Ophthalmology Elective PI: Griffin Jardine, MD

Clinical and Molecular Relationship between Maternal Pre-eclampsia and Retinopathy of Prematurity PI: Leah Owen, MD, PhD

Multivariate Analysis of Variables Affecting Resident Performed Cataract Surgery Complication Rates PI: Jeff Pettey, MD, MBA

Clinical Phenotypes of Inherited Retinal Disease PI: Marielle Young, MD

Assessing a Professionalism Mentor in Academic Medical Departments PI: Jeff Pettey, MD, MBA Tracking Outcomes in Moran Outreach Programs PI: Jeff Pettey, MD, MBA Prevalence of Ophthalmic Disease in a Salt Lake City Homeless Population PI: Jeff Pettey, MD, MBA Job Description, Goals and Responsibilities of a Vice Chair of Education within the Department of Ophthalmology PI: Jeff Pettey, MD, MBA Sight Outcomes Research (SOURCE) Multicenter Ophthalmology EHR Repository PI: Brian C. Stagg, MD Exemption Umbrella: Secondary Analysis of Electronic Medical Record Data to Improve Eyecare PI: Brian C. Stagg, MD

Building Capacity for Pediatric Eye Care in the Navajo Nation PI: Marielle Young, MD

PEDIATRIC RETINA Genetic Associations in Preterm Infants at Risk of Retinopathy of Prematurity PI: Mary Elizabeth Hartnett, MD Retrospective Review of Retinopathy of Prematurity and Associated Conditions PI: Mary Elizabeth Hartnett, MD ROP1—Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity PI: Mary Elizabeth Hartnett, MD ROP2Y—Two-Year Follow-Up after Treatment of 6 Severe Retinopathy of Prematurity with Low-7 Dose Bevacizumab PI: Mary Elizabeth Hartnett, MD Vgfte-ROP-1920— Randomized, Controlled, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoagulation in Patients with Retinopathy of Prematurity PI: Mary Elizabeth Hartnett, MD

JOHN A . MOR A N E Y E CE N T E R

Clinical Trials/Studies for Fiscal Year 2020

DIGIROP2— Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Longitudinal Data PI: Mary Elizabeth Hartnett, MD

RETINA National Ophthalmic Genotyping Network, Stage 1—Creation of Repository for Inherited Ophthalmic Diseases PI: Paul S. Bernstein, MD, PhD Natural History Observation and Registry Study of Macular Telangiectasia Type 2: The MacTel Study PI: Paul S. Bernstein, MD, PhD Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD PI: Paul S. Bernstein, MD, PhD Utah Center for MacTel Genetics: A Study of Subjects Enrolled in “The Macular Telangiectasia Project” at the University of Utah PI: Paul S. Bernstein, MD, PhD Macular Pigment Measurements in Eye and Other Tissues PI: Paul S. Bernstein, MD, PhD 4D Molecular Therapeutics Protocol Number: 4D-CHM-001-NH0001—A Multicenter Prospective Observational “Natural History” Study in Patients with Choroideremia PI: Paul S. Bernstein, MD, PhD

XOLARIS— Natural History of the Progression of X-Linked Retinitis Pigmentosa PI: Paul S. Bernstein, MD, PhD Lutein and Zeaxanthin in Pregnancy (L-ZIP)— Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects PI: Paul S. Bernstein, MD, PhD SeaSTAR: A Phase 3 Multicenter, Randomized, Double-Masked Study Comparing the Efficacy and Safety of Emixustat Hydrochloride with Placebo for the Treatment of Macular Atrophy Secondary to Stargardt Disease PI: Paul S. Bernstein, MD, PhD Phase 1 Open-Label, Dose-Escalation Study of the Safety, Tolerability and Preliminary Efficacy of Intravitreal 4D-110 in Patients with Choroideremia PI: Paul S.Bernstein, MD, PhD NTMT-03 FLIO Sub-Study PI: Paul S. Bernstein, MD, PhD ISEE2008 —A Phase 3 Multicenter, Randomized, Double Masked, Sham-Controlled Clinical Trial to Assess the Safety and Efficacy of Intravitreal Administration of Zimura (Complement C5 Inhibitor) in Patients with Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration PI: Paul S. Bernstein, MD, PhD

Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) (CIRB) PI: Paul S. Bernstein, MD, PhD

4D-125-C001— An Open-label, Phase 1/2 Trial of Gene Therapy 4D-125 in Males with X-linked Retinitis Pigmentosa (XLRP) Caused

by Mutations in the RPGR Gene PI: Paul S. Bernstein, MD, PhD

NTMT-03: A Phase III Multicenter Randomized, Sham Controlled, Study to Determine the Safety and Efficacy of Renexus in Macular Telangiectasia Type 2 PI: Paul S. Bernstein, MD, PhD

Multimodal Retinal Imaging in Pentosan Polysulfate Associated Maculopathy PI: Paul S. Bernstein, MD, PhD

OPH2005— A Phase 2b Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Zimura (Complement C5 Inhibitor) Compared to Sham in Subjects with Autosomal Recessive Stargardt Disease PI: Paul S. Bernstein, MD, PhD Detection of Hydroxychloroquine Levels Using Fluorescence Lifetime Imaging PI: Paul S. Bernstein, MD, PhD My Retina Tracker Genetic Testing Sub-Study: Feasibility of Enhancing the Data Value of the Patient-Driven Registry My Retina Tracker Through the Provision of Clinical Genetic Testing Services PI: Paul S. Bernstein, MD, PhD OAKS-APL2-304— A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degenerations PI: Paul S. Bernstein, MD, PhD

The Effect of NMN Supplementation on the FLIO Patterns of Patients with Early Macular Degeneration PI: Paul S. Bernstein, MD, PhD Spectral Domain Optical Coherence Tomography Imaging of Eyes: A Practical Diagnostic Tool and Methodology PI: Mary Elizabeth Hartnett, MD Growth Factors in Vitreoretinal Diseases PI: Mary Elizabeth Hartnett, MD Re-Opening Genetic Analysis of Coats’ Disease Patients (and Family) and Correlation of Patient Phenotypic and Imaging Data PI: Mary Elizabeth Hartnett, MD Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy (HIE) in Infants PI: Mary Elizabeth Hartnett, MD Retrospective Review of Complications of X-Linked Retinoschisis Especially Causes of Vitreous Hemorrhage PI: Mary Elizabeth Hartnett, MD

JOHN A . MOR A N E Y E CE N T E R

Clinical Trials/Studies for Fiscal Year 2020

Assessing Efforts to Raise Awareness on OCT: Use of Focus Groups PI: Mary Elizabeth Hartnett, MD YOSEMITE —A PHASE III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety Ofro6867461 in Patients with Diabetic Macular Edema PI: Rachael Jacoby, MD RHONE-X GR41987—A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Patients with Diabetic Macular Edema PI: Rachael Jacoby, MD Vitreous Biopsy Analysis PI: Akbar Shakoor, MD Machine Learning Algorithm for Electroretinography Sorting PI: Akbar Shakoor, MD OCT Findings in Patients with Ocular Syphilis PI: Akbar Shakoor, MD

UVEITIS Oral Steroids in the Treatment of Bacterial Endophthalmitis PI: Akbar Shakoor, MD Macular Edema Ranibizumab vs. Intravitreal Anti-Inflammatory Therapy (MERIT) Trial PI: Albert T. Vitale, MD Adalimumab vs. Conventional Immunosuppression for Uveitis (ADVISE) Trial PI: Albert T. Vitale, MD CIRB: Adalimumab in Juvenile Idiopathic Arthritis-Associated Uveitis Stopping Trial (ADJUST) PI: Albert T. Vitale, MD Phacoemulsification Combined with Pars Plana Vitrectomy in Intermediate Uveitis PI: Albert T. Vitale, MD

Grand Rounds for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

GRAND ROUNDS D AT E

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July 17, 2019

Kathleen Digre, MD, Faculty, Moderator

Eccles Health Sciences Library Resources & Moran CORE Update

Nancy Lombardo and Christy Jarvis, Eccles Health Sciences Library, University of Utah

July 31, 2019

Karl Andersen, MSIV, Geisinger Commonwealth School of Medicine

Proliferative Retinopathy in Hemoglobin C Trait

Kathryn Lewis, MSIV, University of California, Riverside

Aniridia: More than Meets the Iris

Rami Gabriel, MSIV, Machine Learning and its Applicability in OCT University of California, Irvine Angiography

Austin Bohner, MSIV, University of Utah

A Case Presentation

August 14, 2019

Jeff Pettey, MD, Faculty, Moderator

Morbidity & Mortality Series

August 21, 2019

Andrew Nelson, MSIV, Diagnosis and Management of Choroidal USC Metastases

Samaeh Dadashazar, MSIV, Texas Tech

Ectropion Uvea and Secondary Glaucoma

Celestine Gregerson, MSIV, University of Utah

Case Presentation: Reversible Cataracts

Braedon Murdock, MSIV, George Washington

Punctate Inner Choroidopathy (PIC)

Brian Bird, MSIV, University of Nevada

A Case of Axenfeld Anomaly

Samuel Whittier, MSIV, University of Utah

A Case Presentation

August 28, 2019 Mark Mifflin, MD

Update on Cornea Collagen Crosslinking and Keratoconus

Austin Nakatsuka, MD, Cornea Fellow

Glad We Caught That

Maddie Rippa, MD, Cornea Fellow

Recurrent Keratitis

September 4, 2019 Sneha Bontu, MD,

Ocular Pathology & Research Fellow

Sean Kennedy, MD,

Ocular Pathology & Research Fellow

Posterior Capsule Opacification Prevention by an Intraocular Lens Incorporating a Micropatterned Membrane on the Posterior Surface

September 11, 2019

Michael A. Dyer, PhD, St. Jude Children’s Research Hospital

Translational Research for Retinoblastoma

September 25, 2019

Lisa Ord, PhD, LCSW, Moderator

Patient Support Program

Corinna Trujillo Tanner, PhD, RN, MSN, ANP

Reframing Expectations of Life Potential of Older Adults with Vision Impairment

Robert M. Christiansen, MD, FACS

Vision Rehabilitation at the Moran Eye Center

Uveal and Capsular Biocompatibility of a New Hydrophobic Acrylic Microincision IOL

Grand Rounds for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

GRAND ROUNDS D AT E

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October 2, 2019

Amy B. Locke, MD, FAAFP, Co-Director, University of Utah Resiliency Center

In Pursuit of Professional Fulfillment: Moving Beyond Burnout

October 9, 2019

Lydia Sauer, MD, University of Utah

Clinical Advances in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO)

Ariana Levin, MD, Resident

Rethinking the Preoperative H&P Requirement Prior to Cataract Surgery

Michael Murri, MD, Resident

Unilateral Blurry Vision and Headache

October 16, 2019

Wai T. Wong, MD, PhD, National Eye Institute

Geographic Atrophy in AMD: Clinical Features and Interventional Trials

October 23, 2019

Brian Zaugg, MD, Faculty, Moderator

Morbidity & Mortality Series

October 30, 2019

Judith Warner, MD, Faculty, Moderator

Neuro-Ophthalmology

Judith Warner, MD, Faculty

Update on Studies

Bradley Katz, MD, PhD, Faculty

Update on Studies

Shanna Swartwood, MD, Pediatric Neurology Resident

Case Presentation: Bilateral Ptosis

Samantha Colby, MD, Neurosurgery Resident

Ophthalmoplegia and Whooshing

November 13, 2019

Joyce Liao, MD, PhD, Stanford University School of Medicine

Hot Topics in Eye-Brain Diseases

November 20, 2019

Rachel Simpson, MD, Faculty, Moderator

Glaucoma

Brian Stagg, MD, Faculty

Glaucoma Update

Arezu Haghighi, MD, Glaucoma Fellow

Bleeding Love

Tina Mamalis, MD, Resident

A Unique Case of UGH Syndrome

December 4, 2019

Rachel Patel, MD, Resident; Srav Vegunta, MD, Resident

Theory, Lore, and Intuition

December 11, 2019

Chris Bair, MD, Resident

The Ocular Hazards of Trumpet Playing

Marshall Huang, MD, Resident

Passing on Cypass

December 18, 2019

Robert Hoffman, MD, Faculty, Moderator

Pediatric Ophthalmology

David Dries, MD, Faculty

Brown Syndrome: Superior Oblique Tendon Lengthening

Griffin Jardine, MD, Faculty

Sudden-Onset Strabismus: To Image or Not to Image?

Rachel Patel, MD, Resident

Peculiar Pediatric Papilledema

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Grand Rounds for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

GRAND ROUNDS D AT E

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January 8, 2020

Bradley Jacobsen, MD, Resident Resident

O Captain! My Captain!

Katherine Hu, MD, Resident

20 Years Later... My Captain Was Wrong

Jeffrey L. Nadel, MD, MS, Neurosurgery Resident

Surgical Management of Idiopathic Intracranial Hypertension

January 15, 2020

Roxana A. Radu, MD, UCLA Stein Eye Institute

Complement Dysregulation: A Link for Stargardt Disease & Age-Related Macular Degeneration

January 22, 2020

Christina Mamalis, MD, Resident

You’ll Shoot Your Eye Out, Kid

Michael Burrow, MD, Resident

Brain Attack!

Doni Widyandana, MD, International Observer

Pesticide Exposure and Ocular Disorders in Ngablak Village, Central Java, Indonesia

January 29, 2020

Albert Vitale, MD, Faculty, Moderator

Retina Ophthalmology

Nikko Ronquillo, MD, PhD; Chris Komanski, MD; Eric Hansen, MD, Retina Fellows

Advancements in Gene Therapy: Exploring the What, Why, and How

February 12, 2020

Brian Zaugg, MD, Faculty, Moderator

Morbidity & Mortality Series

February 19, 2020

Yvonne Ou, MD, University of California, San Francisco

From Clinic to Lab to Clinic Again: Improving Glaucoma Diagnostics

February 26, 2020

Mark Mifflin, MD, Faculty, Moderator

Cornea, Cataract, Refractive SX

Brian Zaugg, MD, Faculty

The Preoperative Cataract Surgery Cornea Eval

Austin Nakatsuka, MD, Cornea Fellow

Should I Be Scared, Doc?

Maddie Ripa, MD, Cornea Fellow

March 4, 2020

Monika Fleckenstein, MD, Faculty

The Other Faces of AMD

Steffen Schmitz-Valckenberg, MD, Faculty

Drusen and Function

April 8 2020

Nancy J. Newman, MD, Emory University School of Medicine

Neuro-Ophthalmology Update

April 15 2020

Ariana Levin, MD Resident; Theresa Long, MD, Resident

COVID-19 Masks: Review of the Latest Science, Sustainable Innovations, and Practical Use

April 22, 2020

Albert Vitale, MD, Faculty, Moderator

Uveitis

Akbar Shakoor, MD

Long-Acting Steroid Implants for Uveitis

Inna Stroh, MD, Uveitis Fellow; Marshall Huang, MD, Resident

MERIT Trial Cases

Cataract Surgery and Management of Astigmatism

Grand Rounds for Fiscal Year 2020

JOHN A . MOR A N E Y E CE N T E R

GRAND ROUNDS D AT E

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T I T L E

April 29, 2020

Jay A. Jacobson, MD, University of Utah School of Medicine; Richard E. Nelson, PhD, University of Utah School of Medicine

COVID-19 Lessons Learned: Infections, Epidemics, Economics

May 13, 2020

Brian Zaugg, MD, Faculty, Moderator

Morbidity & Mortality Series

May 20, 2020

Marshall Huang, Resident; Ariana Levin, Resident; Katherine Hu, Resident; and Mike Murri, Resident

Resident Research Projects

May 27, 2020 Austin Nakatsuka, MD,

Cornea Fellow

Update on the Acute Ocular Management of Stevens-Johnson Syndrome: A Modified Surgical Technique

Alan Crandall, MD, Faculty

Phaco Efficiency Study/ASCRS

June 3, 2020

Chris Bair, MD, Resident

Underrepresented Minorities in Ophthalmology: A Moran Update

Brad Jacobsen, MD, Resident

Cavitary Optic Disc Anomaly in a Family: In Search for a New Genetic Mutation

Rachel Patel, MD,

Resident

Implementation of a CPRS-Based Electronic Medical Record at the SLC VA Ophthalmology Clinic

Theresa Long, MD,

Resident

Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Patients with X-Linked and Other Foveal Schisis

June 10, 2020

Sophia Fang, MD, Global Fellow, Moderator

Global Outreach

Craig Chaya, MD, Faculty; Sanduk Ruit, MD, Tilganga Institute of Ophthalmology; Dan Neely, MD, Orbis International

Sustainability in Global Ophthalmology Outreach

20

JOHN A . MOR A N E Y E CE N T E R

Technology Commercialization and Intellectual Property/Patents for Fiscal Year 2020

TECHNOLOGY COMMERCIALIZATION AND INTELLECTUAL PROPERTY/PATENTS Patents, Patents Pending, Industry & Technology, Technological, and Other Scientific Innovations.

Bradley J. Katz, MD, PhD,

Gregory S. Hageman, PhD,

founder and CEO of Axon Optics, axonoptics.com, joined with Tecport Optics to develop a ground-breaking optical interference filter coating process for plastic spectacle lenses.

The process blocks the specific wavelengths of light that have been implicated as the cause of photophobic symptoms, particularly those associated with triggering and exacerbating debilitating migraine headaches. The University of Utah has registered the existing proprietary property.

is the John A. Moran Presidential Endowed Chair of Ophthalmology and Visual Sciences; executive director, Sharon Eccles Steele Center for Translational Medicine, specializing in the genetics and assessment of pathways involved in the etiology of age-related macular degeneration and retinal cell biology.

Methods, systems, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles, Bradley J. Katz, Patent pending: China, Vol. 36, No. 2001, 2018800621910, Patent pending: Australia, 2018314216, 2018314216, Patent pending: India, 12/2020, 202017005351, Patent pending: European Patent Office (EPO), 3664745, 18843639.8, Patent pending: Republic of Korea, 10-2020-7003867, Patent pending: Canada, 3,072,541, Patent pending: South Africa, 2020/00810, Patent issued: United States, US-2017-0336545-A1, 15/673,26416/800,951, Patent pending: Singapore, 11202000912S, Patent pending: Japan, 2020-507060.

Methods, systems, and apparatus for modulating circadian cycles, Bradley J. Katz, Patent issued: United States, 16/445,085.

Nanoparticle light filtering method and apparatus, Bradley J. Katz, Patent pending: United States, US16/251,510, US20190154894A1, Patent pending: World Intellectual Property Organization (WIPO), WO2015073933A1, PCT/ US2014/065848.

Methods of predicting the development of complementmediated disease, Gregory S. Hageman, Patent pending: United States, US-2020-0239958-A1, 16/734,168.

Methods of diagnosing and treating vascular associated maculopathy and systems thereof, Gregory S. Hageman, Patent pending: United States, 16/806,887.

Methods of predicting the development of AMD based upon chromosome 1 and chromosome 10, Gregory S. Hageman, Patent pending: United States, 16/806,906.

HTRA1 modulation for treatment of AMD, Gregory S. Hageman, Patent pending: World Intellectual Property Organization (WIPO), WO/2020/210724, PCT/ US2020/027802.

Gene therapy for macular degeneration and other chromosome 1-directed diseases, Gregory S. Hageman, Patent pending: World Intellectual Property Organization (WIPO), WO 2020/019002A1, PCT/US2019/042891.

Haibo Wang, MD, PhD, and Mary Elizabeth Hartnett, MD, specialize in the mechanisms of normal and aberrant angiogenesis, particularly related to diabetic retinopathy, retinopathy of prematurity, and AMD. Methods and compositions for the expression of constitutively active RAP1A from a VMD2 promoter, Haibo Wang and Mary Elizabeth Hartnett, Patent pending: United States, 62/905,880.

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