2011 BME Newsletter

Department of Biomedical Engineering 2011 Newsletter Welcome to the 2011 newsletter from Tulane’s Department of Biomedical Engineering. I’m very proud to bring you up to date on the status of our department. We’ve completely rebounded from the interruption that Katrina caused us, thanks in large part to the eight new faculty members who have come on board in the past five years.

Our newsletter, edited by Cedric Walker and the External Constituency Committee , focuses on three themes: People, Research and Outreach.

2011 Events Our website bmen.tulane.edu has more information, and we’d love to hear from you. If come to New Orleans, please feel free to come by, otherwise drop me a note at dpg@tulane.edu.

With best wishes, Donald Gaver Alden J. “Doc” Laborde Professor and Department Chair

January 29th - Senior Research Day

February 26th - Team Design Show (see page 2)

March 17th - Suhren Lecture, Dr. George Truskey, Engineering Endothelial Progenitor Cells for Vascular Repair

April 20th - Annual BME Awards Ceremony

May 11th - Annual Order of the Engineer Induction

May 12th - 2011 Commencement BME will be awarding 15 BS degrees to our senior class, 4 MS degrees and 2 Ph.D. degrees.

October 9 - 11th Come visit our Tulane BME booth at the BMES Conference in Harford, CT.

Research Shevkoplyas Receives Prestigious Grant to Study Red Blood Cell Deterioration Dr. Sergey Shevkoplyas, Assistant Professor of Biomedical Engineering, has been awarded a $74,900 grant by the National Blood Foundation. The Foundation awarded only 8 new grants this year. Shevkoplyas is one of 3 engineers among the 8 recipients. Priority is given to new investigators and innovative projects with the potential to have a practical impact on transfusion recipients and blood donors.

The quality of red blood cells (RBCs) during storage deteriorates as the cells lose certain functional abilities and accumulate oxidative damage over time. This “storage lesion” decreases the ability of RBCs to deliver oxygen effectively in the transfusion patient. With the NBF grant “The Relationship between the Ability of Stored Red Blood Cells to Perfuse Microvascular Networks and their 24-hr Post-Transfusion Recovery in vivo”, Shevkoplyas and colleagues will assess the ability of artificial microvascular networks, or AMVNs, to detect the deterioration in red blood cells that takes place over time.

The researchers are taking advantage of an ongoing clinical study in which RBCs will be collected from volunteers, stored and re-infused back into participants at two-week intervals to determine their 24-hour in vivo recovery. They will measure the AMVN perfusion parameters for these same samples and see whether those parameters correlate with the clinical findings of the study. Shevkoplyas hopes eventually AMVNs such as the ones produced in his lab can be used to screen every RBC unit before transfusion to test the cells’ viability. He said this work brings together his two main research interests – blood banking/transfusion and the use of microfabrication technology to study the properties of RBCs at microscale – which he has studied since he was a doctoral student at Boston University.

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Department of Biomedical Engineering

People Current Students

Gary Catig

Brad Smith

Gary is a 2nd year PhD candidate in Dr. Michael Moore’s lab, studying the diffusive properties of hydrogels and creating controllable gradients of soluble biomolecules.

Gary comes to Tulane from NYU, where he received his Master’s in Biomaterials Science and Johns Hopkins University where he received his Bachelor’s in Materials Science and Engineering.

Brad is a senior PhD candidate in Dr. Donald Gaver’s lab, whose project will lead to saving premature babies from the ravages of respiratory distress syndrome. Brad received both his BSE and MS degrees at Tulane working on a benchtop model of pulmonary airway reopening, and a computational model of damaging mechanical stress during pulsatile airway reopening, respectively.

Gary and his labmates work on the study of diffusive properties of hydrogels and creating controllable gradients of soluble biomolecules within the hydrogels because cells respond more towards gradients of biomolecules rather than their mere presence. By introducing controllable gradients within hydrogel tissue scaffolds, he hopes to influence axon growth for guided neural regeneration. Why is this important?

The lab is creating a “lab on a chip” which is a construct that acts like real tissues on which other researchers can test drugs or devices before using up valuable (and hard to get) real tissues. This saves all of us from being poked, prodded, drugged and just generally bothered unnecessarily by medical research.

When he’s not saving people from being human test dummies, Gary likes dancing, listening to music, and watching sports. He’s originally from Valencia, California but is growing to like New Orleans and Mardi Gras!

He has helped to computationally model airway reopening to explore the stresses at the airway wall which are responsible for cell death (published in the Journal of Fluid Mechanics). To further explore this phenomenon, the Gaver Lab uses micro particle image velocimetry to experimentally measure fluid velocity (with a laser) and bubble shape in a model of airway reopening (published in Measurement Science and Technology, Experiments in Fluids). The computer-controlled translating microscope stage that Brad designed and milled on the CNC for this portion of the project was critical to obtaining experimental results.

When he’s not saving babies, Brad likes traveling by motorcycle, rock and ice climbing, camping, hunting and fishing. Brad is planning to marry a fellow graduate student, Kate Hamlington, this May. After graduation this summer, Brad will start a post-doctoral position in the Vermont Lung Center at the University of Vermont working with Prof. Jason Bates.

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Team Design On February 26, 2011 four teams of BME Seniors presented their design projects to their clients, the public, and a panel of judges. The judges were drawn from a pool of healthcare professionals, faculty, alumni, and former clients. The team earning the highest judge scores was SoundByte. Their objective was to develop a system that would enable a below-the-elbow amputee to play a violin. Team members John Pitre ‘11, Joan Lien ‘11, and Hudson Chien ’11 will receive the Kenneth H. Kuhn, Sr. Memorial Award at a ceremony on April 20th.

Donald Gaver announced that “this was the best show ever,” a fact confirmed by Dave Rice, course leader, who noted that the projects had the highest average judge scores so far.

Each team began working with its client last fall and plans to deliver their finished product this coming April. A list of teams and their projects, along with photographs from the show, are shown by http:// www.tulane.edu/~rice/tdp/2011/ team11.htm .

A historical note: Senior team design shows began in 1980, three years after the founding of the department in 1977. They have been held annually since. Beginning in the 1988-1989 academic year, all teams focused on developing assistive technology for clients who have disabilities.

Department of Biomedical Engineering

People Alumni temper it all with the theatrical stage and you get Nancy Freeman. Nancy graduated in the class of 1979 and was one of only three members of her class who chose not to pursue an MD. Instead, Nancy began her career in Medical Instrumentation working for DuPont in the Medical Products Division.

Her engineering skills were used to provide technical service on hospital instrumentation. From there, however, Nancy found a niche in Our profiled alumna is Nancy technical training and she Freeman Mikkelsen (BME’ 79). began a Masters in Education program while living in Chicago. She was transTake a big shot of New Orleans ferred to Delaware and beflavor, simmer in some engineer- gan dividing her time being classes for 4 years, and then tween technical training and

working on new system development teams. Her work with DuPont was recognized with many corporate awards and recognition.

From DuPont Nancy moved to Pennsylvania and began working for Lutron Electronics. She began revitalizing the customer training programs that for their lighting control customers. The electronics courses she took at Tulane came in handy there!

Then Nancy moved into college recruiting as Director of Education, working with a professional association for nine years while creating and delivering their education programming and running an annual conference.

Opportunities to use what was learned at Tulane. When asked – as she frequently is - what her engineering degree did for her, she responds, “While I have never perhaps been a biomedical engineer in the traditional sense, my engineering education at Tulane is used every day. Engineering education creates thinkers who learn how to creatively solve problems. I firmly believe what Dan Pink espouses on how right brain thinking is what the world needs and my engineering education gave those skills to me. I would not trade it for anything!”

Today, Nancy is exploring her entrepreneurial dreams by work-

People Alumni news Most of these updates are published on the Tulane Biomedical Engineering Students and Alumni group on LinkedIn http:// linkd.in/fVhDZp

Justin Cooper (BSE ’07, MS ’09) reports that he’s working in Honduras and Ghana right now to train biomedical equipment technicians for Join LinkedIn and sign up to be a Engineering World Health part of this community today! (ewh.org/bmet). www.linkedin.com/secure/ register Jonathan Stroud (BSE ’04) reports that he’s in law David Bourn (Ph.D. ’06) reports school at U. of American that he has left Medtronic to join Washington College of Law, Cardiac Concepts, a small and was awarded a Gillettstartup developing a device to Mussey Fellowship for the treat central sleep apnea.

'10 school year. He is also Rochelle W e i c h m a n working full time at the (Engineering ’75 and MS United States Patent and ‘78) reports that she has been Trademark Office in prosthetics. promoted to Associate Dean for Executive Education at MIT Jon also reports that Jess Sloan School of Management Tyra (BSE ’04) married Rob r e s p o n s i b l e f o r d e g r e e d Lunsford (also ‘04).

that produces medical and commercial devices for pediatrics / children. They have 3 global license deals on 7 patents (2 that are issued) and their next product line will hit stores internationally in March 2011. In the US it will at Babies’R’Us. Additionally, full time, he is the Director of Engineering at Portaero, a venture backed emphysema therapy Please support the Departcompany. ment of Biomedical Engineerwww.twinnovationsllc.com

(masters) and non-degreed Josh Weisman (BSE ’05, (certificates) Executive Educa- MS ‘06) reports that he started a biotech company tion.

Kindly visit the SSE's Alumni Support page http:// tulane.edu/sse/alumni/ donations-support.cfm.

ing.

Donations are a great way to show supports for the department, and are tax-deductible.

All donations will be directed to the BMEN Endowment fund and will be used to provide opportunities to our students that would not otherwise be available.

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Research

Department of Biomedical Engineering

Cellular Biomechanics and Biotransport Laboratory In the Cellular Biomechanics and Biotransport Laboratory, Professor Damir Khismatullin is currently leading a team consisting of one post-doc, three PhD students and one MS student. The laboratory focuses on understanding the mechanical behavior of biological systems at cellular and tissue levels. Using both computational and experimental approaches, they investigate the interactions of blood cells (leukocytes, platelets) and tumor cells with vascular endothelium under pathophysiological conditions such as inflammation, atherosclerosis, and cancer metastasis. Another aspect of their research is liver tumor ablation with high-intensity focused ultrasound (HIFU) where they study the mechanical destruction of tumor tissue by ultrasound-produced cavitation bubbles. They also develop novel rheological methods for the characterization of living cells and tissues and use state-ofthe-art computational fluid dynamics models to predict the growth and rupture of intracranial aneurysms. The ultimate goal is to develop novel, optimized approaches for the treatment of cardiovascular disease and cancer.

neers, and clinicians from leading research institutes and hospitals. Damir has collaborated with many Tulane faculty members including Lee Murfee, Michael Moore, and Sergey Shevkoplyas in BME; Daniel De Kee, Kyriakos Papadopoulos, Kim O’Connor, and Vijay John in the Chemical and Biomolecular Engineering; Ricardo Cortez and Lisa Fauci in Math, and Wayne Reed in the Physics Department. His outside collaborators span the country.

Postdoctoral Fellow to develop mathematical models for bubble dynamics in living tissue.

His next stop (from 2001 to 2003) was in the Department of Mathematics at Virginia Tech, where his work lead to a collaboration with Profs. Robert Hochmuth and George Truskey at Duke University. His third stop was in Dr. Truskey’s laboratory, where he spent almost three years in the laboratory conducting numerical studies of leukocyte-endothelial cell adhesion and corresponding in vitro experiments. Before coming to Tulane, his last stop (2006-2008) was again at Boston University, where he was a Research Assistant Professor and an Associate Director of Biomedical EngiProf. Khismatullin’s career path took him neering Computational Simulation Facility. to three American universities before he came to Tulane two years ago. He Damir is very proud of his team members at earned his M.S. degree in Physics and Tulane for having several interesting findings the Ph.D. (in Russia, it’s called and some of them have been already pre“Candidate of Science”) in Physics & sented at the meetings of the Biomedical EngiMathematics from Bashkir State Univer- neering Society (BMES) and the Society of sity, in Ufa, the capital of the Republic of Rheology. Biomedical engineering research is Bashkortostan. Damir’s research inter- interdisciplinary; one cannot imagine modern ests were shifted to the field of Biomedi- science without collaborative work. Damir’s lab cal Engineering in 2000 when he came has active collaborations with scientists, engito Boston University as a NSF-NATO

Damir thinks that it would be difficult to describe what exactly each collaborator brings to the lab. He believes that if you have something on the table, it should not be a problem to establish collaboration.

For example, a lot of researchers in Biomedical Engineering know his studies in 3-D computational modeling of leukocyteendothelial cell interactions. He has a unique model that can test the predictions of experimental work to be done in the collaborating laboratory. When asked how to have effective collaboration, Damir advises “Be realistic about your research.

You cannot do everything, and you need to remember that there are researchers who know something better than you. If you find such a person, explain your research project (with your achievements, of course) and how his/her complementary expertise would benefit the project.”

To learn more about the laboratory, please visit the lab’s website at http:// www.tulane.edu/~damir/

Vision

Mission Statement

The Department of Biomedical Engineering is committed to being a global leader in biomedical engineering scholarship. Our faculty, staff, and students are all important parts of the team that provide distinctive and creative interdisciplinary solutions to biomedical engineering research and design problems. We aim for: excellence in undergraduate and graduate education, meaningful and innovative research, and service dedicated to advancing the field of Biomedical Engineering.

Our mission is to inspire and work with students as we develop and apply engineering methods to confront health science challenges.

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Department of Biomedical Engineering

Outreach Kids Get 'Behind the Scenes' Tour of Biomedical Engineering Engaging in interactive demonstrations varying from regenerative medicine to assistive technology that helps disabled persons, 86 students from 16 New Orleansarea middle schools discovered the world of biomedical engineering with a visit to Tulane University.

The middle school students are members of FIRST Lego League robotics teams.

FIRST (For Inspiration and Recognition of Science and Technology) embraces a grand challenge for its annual competition.

In the 2010 Body Forward challenge, 9 - 14 -year-old students from more than 17,000 teams in 50 countries selected a body part, system or function; identified a problem and an expert in the field; proposed a solution; and shared it with their community.

To provide these young students with a jump-start on their research, Tulane faculty and students from the biomedical engineering and chemical and biomolecular engineering departments recently gave 20-

minute interactive demonstrations to the young students, sharing their research and passion for their fields.

Tulane students participate in FIRST Lego League through two servicelearning courses offered in conjunction with the Tulane Center for Public Service by Annette Oertling, Professor of the Practice and Assistant Dean for K12 Outreach in the School of Science and Engineering. The middle school program involves mentoring a team at one of the eight schools partnering with Tulane in this project.

This upper-tier course fosters leadership, with Tulane students serving as team leaders or technical experts for multiple schools.

Donald Gaver, right, professor and chair of biomedical engineering, explains lung function to Emma Benson and Kaitlyn Calabresi of St. Paul’s Episcopal School.

(Photo by Cindy Stewart)

After their Tulane visit, “my students unanimously agreed that science really is cool,” writes Theresa Saacks, a teacher at St. tant lesson, and they believe they are winDominic School. “FIRST Lego League pro- ners because of this experience [at Tumotes that discovery is more important than lane].” winning. My students learned this impor-

Outreach Research collaborations Collaborations between BME faculty and their counterparts in the School of Medicien are again on the upswing, with more students and faculty going between Uptown and Downtown. One the newest BME faculty members, Associate Professor Dr. Yu-Ping Wang, is getting very familiar with Claiborne Avenue as he frequently goes between the two campuses. Dr. Wang is unique in the BME department in that he has two faculty offices:

one in Lindy Boggs and one in the Tidewater building on Canal Street, 3½ miles apart. Dr. Wang came to Tulane in 2010 from University of Missouri - Kansas City, as part of an 8 faculty / 30 person consortium to create the Center for Bioinformatics and Genomics, directed by Dr. Hong-Wen Deng, who is also an adjunct faculty member of Biomedical Engineering. The Center focuses on such complex diseases as osteoporosis, sarcopenia and obesity and it utilizes an approach that investigates multiple factors, such as the environment, genetics, and epigenetics.

As a result, exciting science is done at both the molecular level and with patients.

In addition to his participation in the Center, Dr. Wang adds a new area of science to the BME department.

His research focus is on

medical image processing and biological data integration.

Included within his goals are improvements in chromosomal imaging to make that technology more readily available, by improving quality while decreasing time and cost. In support of his research, Dr. Wang has both NIH and NSF funding, focused on multiscale genomic imaging informatics.

As an experienced academic, Dr. Wang has quickly settled into Tulane University. His laboratory, which is on the Downtown campus, is up and running with three postdoctoral fellows and two graduate students. “The collaboration of his laboratory with medical center has already begun to bear fruit. Recently, his laboratory was awarded a $35k grant by the Ladies Leukemia League (LLL) with additional $15k matching fund provided

by Tulane Cancer Center (TCC) to develop bioinformatic 5

techniques for accurate subtyping of myelodysplastic syndrome (MDS)”.

However, Dr. Wang spends at least half the week on the Uptown campus. He is currently teaching BMEN3820 Mathematical Modeling of Biological Systems, and in coming semesters he plans to offer a course in Biological Imaging and Image Analysis.

We are excited to have Dr. Wang and his area of research in the department. His direct connection to the School of Public Health and Tropical Medicine and School of Medicine is one of the many steps that the BME department is taking to increase our focus on translating basic biomedical engineering research into the clinic.

Department of Biomedical Engineering Lindy Boggs Center Suite 500 New Orleans, LA 70118 Phone: 504-865-5897 Fax: 504-862-8779 bmen.tulane.edu

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www.bmen.tulane.edu

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Appendix 2010 Annual Report Department of Biomedical Engineering Faculty Nicholas J. Altiero, Professor and Dean of the School of Science and Engineering Taby Ahsan, Assistant Professor Ronald C. Anderson, Associate Professor Ravi K. Birla, Paul and Donna Flower Assistant Professor (as of July 1, 2010) Michael Dancisak, Senior Professor of the Practice and Director of the Center for Anatomical and Movement Science (as of October 1, 2010) Donald P. Gaver, Alden J. ‘Doc’ Laborde Professor and Department Chair Damir Khismatullin, Associate Professor Michael J. Moore, Assistant Professor.

Walter Lee Murfee III, Assistant Professor David A. Rice P.E., Associate Professor and Director of Undergraduate Studies Sergey S. Shevkoplyas, Assistant Professor Cedric F. Walker P.E., Professor Yu-Ping Wang, Associate Professor (as of July 1, 2010) Emeritus Faculty Paul L. Nunez, Professor Emeritus William C. Van Buskirk P.E., Professor and Chair Emeritus of Biomedical Engineering, Dean Emeritus of Engineering Affiliated Faculty San Aung, Professor of the Practice Annette Oertling P.E., Professor of the Practice and Assistant Dean

Archival Publications in 2010 Taby Ahsan, Assistant Professor Ahsan T, Nerem RM: Fluid shear stress promotes an endothelial phenotype during the early differentiation of embryonic stem cells Tissue Eng Part A. Tissue Eng Part A. Nov 2010;16(11):354753.

Duffy GP, D’Arcy S, Ahsan T, Nerem RM, O’Brien T, Barry F. Mesenchymal Stem Cells Overexpressing Ephrin-B2 Rapidly Adopt an Early Endothelial Phenotype with Simultaneous Reduction of Osteogenic Potential. Tissue Eng Part A. Sep 2010;16(9):2755-68.

Gauvin R, Ahsan T, Larouche D, Levesque P, Dube J, Auger FA, Nerem RM, Germain L. A Novel SingleStep Self-Assembly Approach for the Fabrication of Tissue-Engineered Vascular Constructs. Tissue Eng Part A. May 2010;16(5):1737-47.

Duffy GP, Ahsan T*, O'Brien T, Barry F, Nerem RM. Bone marrow-derived mesenchymal stem cells promote angiogenic processes in a time- and dose-dependent manner in vitro. Tissue Eng Part A. Sep 2009;15(9):2459-2470. *co-first author

Ronald C. Anderson, Associate Professor Anderson, R. C. In Enderle, Hallowell (Ed.), Chapter 12: Tulane University NSF: Engineering Senior Design Projects To Aid Persons With Disabilities. Mansfield Center, Connecticut: Creative Learning Press.

Archival Publications in 2010

Ravi K. Birla, Paul and Donna Flower Assistant Professor Sondergaard CS, Hodonsky CJ, Khait L, Shaw J, Sarkar B, Birla RK, Bove E, Nolta J, Si MS, “Human Thymus Mesenchymal Stromal Cells Augment Force Production in Self-Organized Cardiac Tissue”.

Ann Thorac Surg, 90(3):796-804, 2010.

Donald P. Gaver, Alden J. ‘Doc’ Laborde Professor and Department Chair Smith, B.J., E. Yamaguchi and D.P. Gaver. A translating stage system for micro-PIV measurements surrounding the tip of a migrating semi-infinite bubble. Measurement Science and Technology, 21(1): 015401 (13pp), January 2010.

Smith, B.J., and D.P. Gaver. Agent-based computational simulations of droplet dynamics in a two-branch microfluidic network. Lab on Chip, DOI: 10.1039/b916380h, 2010 Zamir, M., J. E. Moore Jr., H. Fujioka, and D. P. Gaver, Biofluid mechanics of special organs and the issue of system control. Annals of Biomedical Engineering, 38(3): 1204-1215, March 2010.

Damir Khismatullin, Associate Professor Wang, W., Zhu, H., De Kee, D. C., Khismatullin, D. B. Numerical Investigation of the reduction of wall slip effects for yield stress fluids in a double concentric cylinder rheometer with slotted rotor Journal of Rheology. 54, 1267-1283.

Walter Lee Murfee III, Assistant Professor Robichaux JL, Tanno E, Rappleye JW, Ceballos M, Stallcup WB, Schmid-Schönbein GW, Murfee WL. (2010) Lymphatic/Blood Endothelial Cell Connections at the Capillary Level in Adult Rat Mesentery.

Anatomical Record. 293: 1629-1638. (Cover Illustration)

Sergey S. Shevkoplyas, Assistant Professor Glodek, A., Mircev, R., Golan, D. E., Khoory, J. A., Burns, J. M., Shevkoplyas, S. S., Nicholson-Weller, A., Ghiran, I. C. (2010). Ligation of complement receptor 1 increases erythrocyte membrane deformability. Blood, 116(26), 6063-71.

Yoshida, T., Shevkoplyas, S. S. (2010). Anaerobic storage of red blood cells. Blood Transfusion, 8(4), 220-36.

Hulme, S. E., Shevkoplyas, S. S., McGuigan, A. P., Apfeld, J., Fontana, W., Whitesides, G. M. (2010).

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans. Lab on a Chip, 10(5), 589-97.

Yu-Ping Wang, Associate Professor J. Chen, Ayten Yiğiter,Y.-P. Wang, and H.-W. Deng, A Bayesian Analysis for Identifying DNA Copy Number Variations Using a Compound Poisson Process, J. Bioinformatics and Systems Biology, Vol. 2010 (2010).

Active Funding in 2010

Co-PIs: Title: Source: Total direct cost Period:

Donald Gaver and Ronald Anderson Innovating Biomedical Design in Undergraduate Engineering Education 2009 HP Innovations in Education $260,000.00 May 1, 2010 - April 30, 2012

PI: Title: Source: Total direct cost Period:

Ravi Birla Fabrication of 3D Cardiac Patches for Myocardial Regeneration National Institute of Health, R01-EB011516 $1.0M 04/01/10- 03/31/14

P.I.s: Title: Source: Direct Costs: Duration:

Donald P. Gaver and Lisa Fauci Biocomputing: Integrating Molecular/Organ-Level Function National Institutes of Health Pre- National Program of Excellence in Biomedical Computing (1 P20 EB001432-01) $851,944+$162,886 (sup)=$1,014,830 5/1/03-4/30/08

P.I.s: Title: Source Direct Costs: Duration:

Donald P. Gaver Engineering Ventilation Waveforms to Reduce Atelectrauma National Institutes of Health Individual Investigator Award (R01-HL81266) $1,100,000 6/1/06-5/30/10

P.I. Co-P.I. Title: Source: Period: Amount:

Seidel, E. Perdew, J. P., Levy, L. S., Gaver, D. P., Cortez, R. LONI Institute: Advancing Biology, Materials, and Computational Sciences Louisiana Board of Regents July 1, 2007 - June 30, 2012 $1,371,609.00

P.I. Co-P.I. Title Source: Period: Amount:

Cortez, R. Gaver, D. P. Research Infrastructure Improvement NSF EPSCoR October 1, 2007 - September 30, 2010 $1,913,373.00

P.I. Title: Source: Period: Amount:

Khismatullin, D. B. Mathematical modeling of bubble cluster dynamics in a spherical resonator Department of Defense /Impulse Devices, Inc/ Boston University January 1, 2010 - June 30, 2010 $50,000.00

P.I. Title: Source: Period: Amount:

Moore, M. J. Engineered Tissue Culture Microenvironments for Studies in Axon Regeneration Louisiana Board of Regents June 1, 2009 - June 30, 2011 $159,676.00

P.I. Title: Source: Period:

Moore, M. J. Localized Immobilization of Ephrin-B2 for Neurite Guidance in 3D Culture National Institutes of Health June 1, 2009 - May 31, 2011

Active Funding in 2010

Amount:

$327,900.00

Investigator: PI: Title: Source: Amount: Duration:

Murfee, W. L. L. Gabriel Navar Tulane COBRE in Hypertension and Renal Biology NIH Centers of Biomedical Research Excellence COBRE $55,607 (direct costs for subproject) 07/10 - 06/11 (for subproject)

PI: Title: Source: Amount: Duration:

Murfee WL Identification of Lymphatic Vessel Structure and Function in Adult Microvascular Networks Louisiana Board of Regents $163,254 06/09 - 06/12

PIs: Co-PIs: Title: Source: Duration: Amount:

Gaver DP, Han Y, Moore MJ, Murfee WL, Overby DO Phinney D, Chiu E, Scandurro A The Development of a Functional Imaging Resource Tulane REF 01/08 - 01/10 $87,500

PI: Title: Source: Duration: Amount:

Rice, D. A. Senior Projects: Designs for People With Disabilities NSF July 2005 - June 2010 $75,000.00

PI: Title: Source: Duration: Amount:

Rice, D. A. Diabetic Foot Ulcer Transdermal Oxygen Delivery System NCIIA October 1, 2010 - April 30, 2011 $500.00

Co-PI PI: Title: Source:

Shevkoplyas, S. S. George M. Whitesides Zero-Cost Diagnostics Subcontract under award #51308 from The Bill & Melinda Gates Foundation to Harvard University November 1, 2008 - October 31, 2013 $482,251.00

Period: Amount: PI Title: Source: Period: Amount:

Shevkoplyas, S. S. The relationship between the ability of stored red blood cells to perfuse microvascular networks and their 24-hr post-transfusion recovery in vivo National Blood Foundation July 1, 2010 - June 30, 2011 $74,990.00

PI Title: Source: Period: Amount:

Shevkoplyas, S. S. Automated blood component separator Subcontract from Antek Inc., DoD STTR Phase I, U.S. Army -- USAMRAA November 1, 2010 - April 24, 2011 $32,000.00

Active Funding in 2010

PI: Title: Source: Period: Amount:

Wang, Yu-Ping Accurate detection of chromosomal abnormalities with multi-color image processing, NIH 1R15GM088802-01 09/21/2009-8/20/2012 $241,341.

PI: Title: Source: Period: Amount:

Wang, Yu-Ping A New Paradigm for Integrated Analysis of Multiscale Genomic Imaging Datasets NIH 1R21LM010042-01 07/01/2009-06/30/2011 $404,459

PI: Title: Source: Period: Amount:

Wang, Yu-Ping Multiscale Genomic Imaging Informatics NSF, DBI 0849932 12/01/2009-11/30/2012 $536,175.

Theses and Dissertations completed in 2010

Student

Degree

Advisor

Dissertation / Thesis title

Yang, Hongli

PhD

Don Gaver, co-chair with Claude Burgoyne

Cigan, Alexander D.

MS

Ron Anderson, co-chair

Smith, Bradford J.

MS

Donald Gaver, chair

Wiesman, Joshua P.

MS

Donald Gaver, chair

Winter, William R.

MS

Paul Nunez, Chair

Zwolak, Nicholas R.

MS

Kirk Bundy, Chair

Optic Nerve Head Biomechanics of Normal and Glaucomatous Monkeys: An Experimental and Computational study The role of doublecortin in mobility of articular chondrocytes The pulsatile propagation of a finger of air through a fluid-occluded cylindrical tube.

Energy-depleting fluid-flow disturbances associated with small pressure change: relevance to obstructed total cavopulmonary connections Spatial Effects in EEG and MEG Coherence Investigation into the optimization and mechanisms of action of urease-based biosensors.

One student (Robbie Whitman) completed the requirements for the non-thesis MS in 2010.