Mustela press file general 2015

of innovations In 1950, Paul Berthomé – father of Laboratoires Expanscience’s current CEO – joined forces with the pharmacist Claude Guillon to create the first cleansing milk for babies to be sold exclusively in pharmacies.

He called it Mustela® – the Latin word for “stoat” – the small animal whose coat goes completely white in winter. A reference to the gentleness and purity at the very heart of the product’s formula. When the first cleansing milk was developed, there was nothing quite like it on the market, but with its instantly recognisable fragrance, it quickly became very popular among mothers. The Mustela® revolution was under way – and it continues to this day.

60 YEARS

OF INNOVATION AND EXPERTISE

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of innovations

KEY EVENTS IN THE HISTORY OF MUSTELA® 1950 The Mustela® brand was created.

The first cleansing milk was launched, for exclusive sale in pharmacies.

1953

The first Cold Cream face skin care product for babies was launched.

1960

The first range of sun protection products for babies was created.

1979 Mustela® Femme – the first range of products for young and expectant mothers – was created.

1987

The first 2-in-1 hair and body wash was launched.

1994 Mustela® 9 months, the first complete range of products designed to take care of women’s skin throughout pregnancy was launched.

Mustela® Bébé Dermo-Cleanser was launched: a very gentle cleansing gel that is ideal for babies starting from birth and which is now the most commonly used in maternity units in France.

1999 Mustela®’s Dermo-Pediatrics line of products was launched, incorporating the Stelatopia range for atopic skin types.

Physiobébé was launched: the 1st leading no-rinse cleansing water for babies.

2013 Global innovation. Following a research programme lasting more than 10 years focusing on babies’ skin, Mustela® rejuvenated its Mustela® Bébé and suncare lines with a range of new generation protection products: Avocado Perseose®, a patented natural ingredient which helps protect the skin, strengthening its cutaneous barrier and preserving its wealth of cells. New formulas which are increasingly natural and which now contain 92% natural ingredients on average.

2014 Mustela® 123 Vitamin Barrier Cream was launched: a new generation of nappy change cream that has resulted in 12 patents. It is the only product that guarantees three-fold preventive, soothing and curative efficacy while being high-tolerance and uniquely enjoyable to use at every nappy change on a daily basis. Preservative-free. 98% ingredients of natural origin.

2015 The Mustela® 9 months range became Mustela® Maternité. Reformulated to factor in the latest discoveries in the field of dermatology, it now provides solutions for all of the changes that women’s skin undergoes during and after pregnancy, safely for mother and baby.

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of skins

4

RANGES OF

SKIN CARE

AND HYGIENE

PRODUCTS

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Comprising four lines of care and hygiene products, Mustela® is the only brand to feature a complete range that meets all the skin requirements of babies and children from birth on – as well as those of new and expectant mothers throughout their experience of motherhood.

All Mustela® products are the results of the very latest research breakthroughs and are designed in accordance with the principles of sustainable development. They meet a selection of unique requirements in terms of quality, efficacy, safety and pleasure of use and have been tested under dermatological and pediatric control.

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of skins

THE 4 MUSTELA® RANGES MUSTELA® BÉBÉ A complete range for cleansing your baby, bathing them, looking after their hygiene and changing them, designed for the fragile and delicate skin of newborns, babies and children. Products which combine efficacy and tolerance with all the pleasure of a unique fragrance.

A COMPLETE RANGE for: • daily hygiene (cleansing milk, no-rinse Physiobébé cleansing water)

• bath time (Dermo-Cleanser cleansing gel, 2-in-1 hair and body wash, multi-sensory bubble bath) • diaper care (1>2>3 Vitamin Barrier Cream) • day-to-day care (Hydra Bébé face cream and body lotion) • well-being (Massage oil, Musti eau de soin)

MUSTELA® DERMO-PEDIATRICS A complete line of fragrance-free hygiene and care, products for specific skincare concerns in newborns, babies and children: Stelatopia for extremely dry and eczemaprone skin, Stelaprotect for intolerant reactive skin, Stelatria for dry and irritated areas, Stelaker for cradle caps.

MUSTELA® SUNCARE High-tolerance skin care specifically formulated to protect babies’ and children’s skin that is particularly vulnerable to sunlight. An exclusive organo-mineral photoprotective system that combines high-protection 50+ UVA UVB filters and a patented natural active ingredient – Avocado Perseose® – which guarantees increased cellular protection and which has been clinically proven.

MUSTELA® MATERNITÉ A complete line of products specially developed to care for women’s skin as it evolves during pregnancy and then once they have given birth: stretchmarks, dryness and itching, firmness, heavy legs, etc.

Clinically-proven efficacy under dermatological control.

Guaranteed safety both for mother and baby: formulas that are compatible with breastfeeding.

All the pleasure of textures that have been specially formulated and a light fragrance to create a unique sensory experience.

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of a laboratory Mustela ® is a brand owned by Laboratoires Expanscience, an independent French pharmaceutical and demo-cosmetics laboratory which generated revenues of €269.8 billion in 2014 – 46.1% through international sales – and which employs 967 people throughout the world.

Over more than 60 years, the company has built up a solid international reputation as an innovator and as a specialist in skin and the treatment of osteoarthritis. Its products, which include two leading brands – Piasclédine 300 and Mustela® – are sold in over 98 countries (84 distributor countries and 14 subsidiaries). Expanscience also develops and markets active ingredients of natural origin for the French and international cosmetics industry.

LABORATOIRES EXPANSCIENCE

The whole value chain is integrated into the company, from research through production and distribution.

2014 TURNOVER:

Its CSR policy, which was introduced 10 years ago, was recognised as exemplary by AFAQ 26000 assessments in 2013 and 2014.

€269.8 M 98 COUNTRIES

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of a laboratory

60 YEARS OF DERMATOLOGICAL RESEARCH AT THE CUTTING EDGE OF INNOVATION A CUTTING-EDGE R&D CENTRE T he research and development centre, located at the Épernon site in France’s Eure-et-Loir region, is the scientific and technical hub of Laboratoires Expanscience.

N early 60 researchers and experts (in plant chemistry, biology and dermatology) work there.

EXPERTISE IN PLANT-BASED ACTIVE INGREDIENTS FOR COSMETICS For more than 30 years, Expanscience has been developing innovative natural active ingredients that are safe and effective thanks to its control over the supply chains and its expertise in plant extraction.

UNIQUE DERMATOLOGICAL EXPERTISE A complete understanding of the physiology of skin at cellular level from the cutaneous barrier right down to the lowest-lying layers of the epidermis.

Innovative investigative technologies: • Models of human skin exclusively reconstructed in laboratories – a world first • Breakthrough non-invasive imaging techniques

INTERNATIONAL SCIENTIFIC RECOGNITION Discoveries that have led to numerous publications in leading scientific journals.

432

SCIENTIFIC POSTERS

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69

CONFERENCES AT INTERNATIONAL CONFERENCES AND SYMPOSIUMS

52

PUBLICATIONS

723

PATENTS FILED WORLDWIDE

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of dermatological expertise Mustela® researchers from Laboratoires Expanscience conducted a unique 11 years world scientific programme, designed to bring about a better understanding of the physiology of babies’ skin.

They have discovered that babies’ skin has an unsuspected wealth at birth: a stock of stem cells that remain unique throughout life. These cells enable the skin to keep regenerating… but they are extremely vulnerable until the age of two, the period during which the cutaneous barrier is being formed.

EXPERT

In order to protect this precious resource, Expanscience has designed and patented an exclusive active ingredient – Avocado Perseose®, that can provide these precious cells with protection against external stresses.

IN BABIES’ SKIN FROM BIRTH ON

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of dermatological expertise

OUR LATEST DISCOVERIES ON BABIES’ SKIN FROM BIRTH ON EV.E.I.L.S, A WORLD FIRST

A WORLD FIRST: 10 YEARS OF RESEARCH TO REVOLUTIONISE SKINCARE PRODUCTS FOR BABIES The EV.E.I.L.S (EValuation of the Early Infant Life: the Skin) programme – a unique fundamental research programme – has resulted in a better understanding of babies’ skin from the first days of life, so as to better address its specific requirements.

•O ur researchers have studied the physiology of babies’ skin from the cutaneous barrier right down to the lowest-lying layers of the epidermis.

10

YEARS OF RESEARCH

•F or their research, they used innovative non-invasive imaging technologies and succeeded – for the first time ever – in recreating the skin of newborn babies in a laboratory environment, providing them with the opportunity to explore it at the cellular level.

3 MAJOR DERMATOLOGICAL DISCOVERIES The cutaneous barrier is not fully developed at birth and only starts to reach maturity when the child is around two years old. A child’s skin is therefore very vulnerable to everyday stresses.

10

PATENTS

It is not yet able to retain the moisture it needs for its cells to function properly.

R ight from birth, babies’ skin is richer than anyone could possibly have imagined: a stock of stem cells which remain unique throughout life, and which are at their maximum strength at birth, make up the skin’s life force and enable it to regenerate throughout life.

These discoveries have resulted in a whole new generation of Mustela® bébé products formulated with Avocado Perseose®, a patented active ingredient that protects babies’ skin and supports it as it develops.

22

SCIENTIFIC PUBLICATIONS including 2 in the British Journal of Dermatology

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The EV.E.I.L.S research programme: more than 10 years of research – world first – into babies’ skin, from birth on, has resulted in 10 patents and 22 scientific publications, including 2 in the prestigious British Journal of Dermatology.

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of plant-based active ingredients Mustela® has always looked to the plant world to source the main active ingredients that make up its products. Using their unique expertise in plant extraction, Laboratoires Expanscience’s researchers have selected the avocado from among dozens of other possible plants and have succeeded in identifying molecules inside it that are extremely rare in nature.

AVOCADO

These molecules have been extracted, purified and concentrated and have yielded a natural active ingredient: Avocado Perseose®, designed and patented by our researchers in order to protect the skin’s wealth of cells and used in all new Mustela® bébé formulas.

USED IN ALL

MUSTELA® FORMULAS

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of plant-based active ingredients

AVOCADO PERSEOSE®, A PATENTED NATURAL ACTIVE INGREDIENT AT THE HEART OF ALL OUR PRODUCTS BIOMIMETIC ACTIVE INGREDIENT Avocado Perseose® is one of a new generation of biomimetic active ingredients: natural active ingredients that are able to act in perfect harmony with a baby’s skin, thus combining maximum tolerance with targeted efficacy.

TARGETED ACTION ON THE CUTANEOUS BARRIER AND THE SKIN’S CELL RESERVES Avocado Perseose® is the perfect ally for babies’ skin and functions like a shield to protect it from outside attacks. It actively aids the development of the cutaneous barrier, helps maintain skin hydration level while protecting the skin’s cell reserves against everyday stresses.

UNIQUE AND PATENTED EXTRACTION PROCESSES Thanks to our expertise in plant biology and the knowledge we have of the chemicals found in avocados, a unique and patented process has been used to extract Avocado Perseose® from the plant. Avocado Perseose® is an extremely rare molecule and given that it is found in concentrations of less than 1% in fresh avocado, it was a real technological challenge to purify, preserve and concentrate it.

AN ACTIVE INGREDIENT SOURCED FROM A RESPONSIBLE SUPPLY CHAIN Supply lines that are sustainable and properly controlled, supervised by the UEBT (Union for Ethical Bio Trade). The avocados that Mustela® uses are grown in compliance with good environmental practices and come with traceability guarantees.

100% OF AVOCAD

O

RECOVE RE

D

AVOCADO LIFE CYCLE Cakes

Raw oil REFINING

Refined avocado oil

GRINDING

Exfoliating avocado powder

ESTERIFICATION

5α Avocuta® EXTRACTION

SLICING AND DRYING

Avocado sugars (C7)

Concentrated avocado oil

ENZYMATIC HYDROLYSIS

Avocado peptides

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MOLECULAR DISTILLATION (MD)

MD+EXTRACTION

Free fatty acids

Unsaponifiable avocado oil

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of efficacy Thanks to its unique knowledge of the physiology of skin in children and babies starting from birth, Laboratoires Expanscience has been able to join forces with researchers and dermatologists and develop targeted solutions to specific skin problems in mothers and babies.

All MustelaÂŽ products undergo systematic clinical tests under dermatological or pediatric control in order to evaluate them.

These tests are conducted in real-life situations in order to guarantee scientifically proven efficacy and high tolerance, from birth on.

CLINICALLY

PROVEN EFFICACY

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of efficacy

CLINICALLY PROVEN EFFICACY, UNDER MEDICAL CONTROL MUSTELA® BÉBÉ Numerous tests are carried out to guarantee the efficacy of Mustela® products, using unique and patented processes: Proven efficacy tested in vitro on STELASKIN®, a reconstructed baby’s epidermis – a world exclusive for Mustela® Efficacy in real-life conditions on babies starting from birth: • Observational tests under dermatological and pediatric control, in real-life conditions • Evaluation from birth onwards systematically including a group of babies under one month old

1>2>3 VITAMIN BARRIER CREAM Its three-fold preventive, soothing and repairing efficacy has been clinically proven in real-life conditions on 120 babies over a 4-week period under dermatological control.

A major world innovation: researchers have developed the first in vitro epidermis model that mimics diaper rash. By reproducing the stressed epidermises of 12-month-old babies – the age when diapesr rash reaches its peak – our researchers have been able to test in extreme conditions a wide selection of active ingredients and have succeeded in developing a unique cocktail that has proven completely effective on irritations and nappy rash.

STELATOPIA The Stelatopia range, specially formulated to relieve itching and dryness in atopic-prone skin, has been clinically tested on more than 600 babies and children aged two months and older.

MUSTELA® MATERNITÉ A n unprecedented system for assessing the efficacy of the new range of Mustela® Maternité products: 330 young and expectant mothers took part in clinical trials under dermatological control.

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of safety Mustela® is committed to safeguarding the health and well-being of both children right from birth and of mothers as soon as they become pregnant with products that guarantee scientifically proven efficacy and safety.

Its strict formulation charter – supervised by an independent expert toxicologist – goes way beyond current conventional cosmetics standards. It gives priority to ingredients of natural origin and is underpinned by practices that involve selecting rigorously ingredients that meet all requirements in terms of safety and efficacy.

Each and every Mustela® formula undergoes rigorous testing under dermatological and/or pediatric control in maximizing cutaneous sensibility conditions. All Mustela® products are hypoallergenic(1), hig h tole ra nce fr om bi r t h on ( 2 ) and ar e fr ee of p arabe n , phenoxyethanol, phtalate.

(1) Formulated to minimize risks of allergic reaction.

(2) Including newborns out of NICU.

million Mustela products ®

sold in more than

90 in 2014 countries

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Mustela® product purchased every

SECOND

around the world

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of safety

THE NEED FOR SECURITY AND SAFETY, RIGHT FROM BIRTH ASSESSED AND CLINICALLY PROVEN SAFETY Hypoallergenic (formulated in order to minimise the risk of allergic reaction) and high-tolerance formulas.

Clinically tested formulas under dermatological or pediatric control.

A STRICT AND SPECIFIC FORMULATION CHARTER Ingredients that are rigorously selected using a strict set of specifications approved by a committee of scientific experts and an independent expert toxicologist who certifies that Mustela® products are completely safe.

Exclusion of controversial ingredients – beyond those which are prohibited by current standards in the cosmetics and perfume industries: Parabens, Phenoxyethanol, Phthalates, EDTA, Sodium Laureth Sulfate (SLS), Chlorphenesin, halogenated derivatives, Silicones, Bisphenols A and S, caffeine, ethylic alcohol, Méthylisothiazolinone (MIT), essential oils, extracts of genetically modified plants, etc., to answer parents’ expectations.

Safe and delicate fragrances that meet strictly defined specifications, and which do not contain 26 potentially allergenic substances (1).

PRIORITY GIVEN TO INGREDIENTS OF NATURAL ORIGIN 92% ingredients of natural origin on average in Mustela® bébé products, while Mustela® Maternité products contain 85%.

GUARANTEED TOLERANCE FROM BIRTH ON Each Mustela® formula undergoes tolerance testing both in vitro and in vivo using unique and patented processes: • on models of reconstructed baby and child epidermises – a world first that has been patented by Laboratoires Expanscience.

• in real-life conditions under dermatological and pediatric control on groups of babies which always include babies under four weeks old.

(1) European guidelines 2003/15.

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of sensory experience Skin is not simply a protective envelope around us and an essential organ. It is also a vector via which we experience emotion and the outside world; it is connected to all of our senses. This is why it has been the focus of all our efforts more than 60 years.

Mustela® therefore takes special care to ensure that the products it develops have pleasant textures and delicate fragrances.

Mustela® Bébé products are highly sensorial and enhance those intimate moments between a mother, a father and their child, thus contributing to feelings of well-being while gently stimulating their senses.

SKIN

THE FOCUS OF ALL OUR

EFFORTS

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of sensory experience

SKIN, A VECTOR FOR STIMULUS AND EMOTION MUSTELA®, A UNIQUE VISION OF SKIN One of the body’s vital organs, skin is a protective envelope and it needs to be taken care of right from the first few days of life.

It is also connected to all of our senses and serves as a vector via which we experience emotion. The very first way that a baby interacts with the people around them is via their skin – by being touched, by being exposed to fragrances.

S ince skin has a dual protective and sensory role, it is the focus of Mustela’s investigations and unique expertise.

FOR UNRIVALLED SENSORY PLEASURE Drawing on sophisticated work in sensory analysis, Mustela® goes to special efforts to develop pleasant textures and delicate fragrances.

The result is that Mustela® products provide unique comfort and enjoyment while turning every aspect of your baby’s skin care routine into a moment of well-being as their senses gently develop.

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of responsibility For more than 10 years, Mustela® has been incorporating a responsible approach in relation to people and the environment into its brand strategy. This has involved 2 major commitments: Sustainable development, implementing initiatives to limit the social and environmental impact that our business has – starting from when our raw materials are sourced right up until our products’ end of life.

Support for new and expectant mothers, providing them with expert and reliable advice on practical issues and routines that will help their child get used to the product in question so that mother and baby can fully enjoy these moments of shared closeness.

A RESPONSIBLE

BRAND

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of responsibility

A RESPONSIBLE APPROACH THAT RESPECTS PEOPLE AND ENVIRONMENT PROTECTING THE ENVIRONMENT

100% OF PRODUCTS IN THE MUSTELA® BÉBÉ* RANGE HAVE BEEN ECO-DESIGNED PACKAGING:

SOURCING:

Reduction in the weight of bottles: 72 tonnes of plastic saved in 2014.

The cardboard used for packaging is made from sustainably-managed forests and plant-based inks.

PRODUCTION:

PRODUCT END-OF-LIFE: 100% of bottles and boxes are recyclable .

(1)

100% of foaming cleansing formulas are biodegradable (2).

Commitment to reducing energy consumption (3).

25.9%

less water

13.7%

less electricity

27.5%

less gas

USE: Products that are intelligently designed so as to keep the amount of packaging required to a minimum.

Consumer awareness-raising of selective sorting.

TRANSPORT/DISTRIBUTION: Lower pollution: 11% reduction in greenhouse gas emissions between 2008 and 2011.

Expanscience data

( 1) According to french recyclability criteria. (2) OECD 302B. (3) End of 2014, at Epernon plant, for 100 units produced.

*70% of total volumes of Mustela® products sold throughout the world

Taking care of young children also means protecting their environment, which is why all Mustela® care products are designed to minimise their impact on the planet.

SUPPORT FOR YOUNG AND EXPECTANT PARENTS The brand has created a wide range of information and support tools.

Numerous information guides and brochures, and educational videos presenting the main baby care rituals (toilet, bath, diaper care, hydration, massage), designed in partnership with healthcare professionals are available to allow the young parents to take advantage of moments of complicity share with their baby.

The digital programme “Mustela® and me”, wich offers expert advice and testimonials from other mothers, is dedicated to future and new mothers, to accompany them throughout their pregnancy and beyond, to help them experience a fulfilling motherhood.

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of professionals Underpinned by more than 60 years of research and expertise in pediatric dermatology, Mustela® is a leading brand for healthcare professionals: recommended by pharmacists prescribed by doctors: pediatricians and dermatologists recommended by midwives Well-established partnerships with world-renowned healthcare professionals for designing and testing products and carrying out wide-ranging research programmes.

Mustela® has always invested a great deal of time in healthcare professionals, keeping them informed, providing them with training and sharing information about the very latest scientific breakthroughs with them by attending international symposiums and conferences.

PARTNER

OF HEALTH PROFESSIONALS

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of professionals

MUSTELA®, PARTNER OF HEALTHCARE PROFESSIONALS DERMATOLOGISTS AND PEDIATRICIANS Close collaboration with world-renowned dermatology researchers in developing formulations and conducting clinical trials.

I nternational symposiums and conferences (JDP Paris, WCPD Madrid, CILAD Rio de Janeiro, etc.) at which our research is presented and which are attended by huge numbers of healthcare professionals from all over the world.

A wide range of information and training tools to extend their knowledge and help them benefit from the latest scientific breakthroughs.

MATERNITY WARDS / MIDWIVES The leading brand in maternity wards in France*, the brand is used in more than 2000 maternity units throughout the world.

O ur products are recommended by midwives who provide young and expectant mothers with support and who listen to their needs so that they can provide them with their expert advice.

Mustela® therefore plays a major role in training programmes delivered to teams of care providers, particularly for when women are preparing to give birth.

PHARMACISTS C hemists – Europe’s well-established distribution channel: Mustela® has chosen selective distribution which places the emphasis on advice and service.

Constant rigour when it comes to quality and safety for giving suitable advice: provide dermo-cosmetics products that meet parents’ expectations and which meet the requirements of prescribers. *Internal source: More than 360 partner maternity units in France

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of commitment

in support of early childhood The Mustela Foundation was created in 1982 by Paul Berthomé, chairman of Laboratoires Expanscience, “to encourage research and projects on child development and parenting all over the world”.

Working under the auspices of the Fondation de France, it has remained true to its initial intention – working for children’s well-being – whilst updating its working methods.

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of commitment

THE MUSTELA FOUNDATION RESEARCH Today, as it has for 32 years, the Mustela Foundation supports research by awarding university grants to both students and experienced researchers. To date, it has supported a total of around 100 projects in the fields of psychology, sociology, psychiatry, pediatrics and, since 2012, maieutic.

IN THE FIELD The Mustela Foundation is also highly committed to work in the field, through the award of the annual Social Pediatrics Prize and the backing it offers to associations that support children.

PREVENTION Since 1986, the Mustela Foundation has also been working to promote prevention and awareness-raising in public health, by producing and distributing literature on childcare, obstetrics and pediatrics and publishing guides and, more recently, educational interactive modules on the internet developed with health professionals.

INTERNATIONAL Finally, the Mustela Foundation has expanded its field of action to other countries rather than restricting its commitments to France. First and foremost, it provides long-term support to a humanitarian partner abroad with a commitment to the mother-child relationship.

This is supplemented by local actions in countries where Laboratoires Expanscience has a subsidiary.

www.fondationmustela.com 33 YEARS

OF ACTIVITY IN FRANCE:

112

RESEARCH GRANTS since 1982

22

PUBLICATIONS

68 000 copies of information and awareness materials distributed

12 000 EUROS:

research grants

INTERNATIONAL

10 000

10 000

maieutic prizes

Social Paediatrics Award

EUROS:

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EUROS:

54 500 EUROS:

actions in the field and partnership

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