KAIMRC Innovations Issue 9

Page 60

Sequencing immune system genes for stem cell transplant success Sequence data from immune system genes of nearly 29,000 Saudi stem cell donors will help match them to patients

A

n improvement in the Saudi Stem Cell Donor Registry (SSCDR) means that patients in need of stem cell transplants will have a lower risk of complications. The addition of sequence data from the immune genes of potential donors reduces the chance of a mismatch. SSCDR, launched in 2011 by King Abdullah International Medical Research Center(KAIMRC) and the Ministry of National Guard Health Affairs, lists more than 75,000 registered potential donors who are willing to donate their blood-forming hematopoietic stem cells (HSCs) to patients around the world with life-threatening diseases such as leukaemia. Transplanted HSCs can reboot the production of healthy blood cells, but they need to be compatible with the patients’ immune system.

60

June 2021


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DIVERSE DISORDERS FROM A SINGLE SOURCE

2min
page 65

PINNING DOWN A GENETIC CAUSE OF PROSTATE CANCER RISK

2min
page 64

SEQUENCING IMMUNE SYSTEM GENES FOR STEM-CELL TRANSPLANTS

2min
pages 60-61

A MOLECULAR LINK BETWEEN DIABETES, OBESITY, AND CELL AGEING

2min
pages 62-63

A KEY ROLE FOR MICROGLIA IN CHILDHOOD GLAUCOMA

2min
pages 58-59

INVESTIGATING THE FACTORS AFFECTING BURN PATIENT SURVIVAL

17min
pages 51-57

AI-SUPPORTED DECISION-MAKING IMPROVES SKIN CANCER DIAGNOSIS

2min
pages 48-49

REDUCING INFLAMMATION REJUVENATES BRAIN CELLS IN MICE

5min
pages 40-41

THE GENETIC ROOTS OF RARE DEVELOPMENTAL DISORDERS

6min
pages 44-45

HOW MELANOMA MANIPULATES ITS WAY TO METASTASIS

2min
pages 46-47

FAMILY SUPPORT HASTENS RECOVERY

2min
page 50

DEPRESSION LINKED TO PREMATURE BRAIN AGEING

5min
pages 42-43

TURNING SCIENTIFIC DISCOVERIES INTO COMMERCIAL SOLUTIONS

4min
pages 38-39

COVID-19 IMPACT DOES NOT END WITH HOSPITAL DISCHARGE

2min
pages 36-37

DNA SEQUENCING ACCELERATES INFECTION DIAGNOSIS

3min
pages 16-19

CHADOX1: MORE THAN A CORONAVIRUS VACCINE

5min
pages 32-34

COVID-19 INFECTION RATE WAS LOW AMONG HEALTHCARE WORKERS EARLY IN THE PANDEMIC

2min
page 27

OPTIMISING INFLUENZA VACCINES TO HARNESS PRE-EXISTING IMMUNITY

2min
pages 10-11

ANTIBIOTIC RESISTANCE IN CIRCULATING BACTERIAL STRAINS

2min
pages 14-15

BETTER ANIMAL MODELS FOR COVID-19 NEEDED

2min
page 35

FIGHTING THE PANDEMIC ON ALL FRONTS

5min
pages 8-9
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