Connections
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Targeting FSHD With Designed Antisense RNAs Written by Abbie Roth Facioscapulohumeral muscular dystrophy (FSHD) arises from genetic and epigenetic changes that result in expression of the DUX4 gene in muscle. Researchers have described small nuclear RNA antisense expression cassettes as a way to silence the DUX4 gene underlying facioscapulohumeral muscular dystrophy. PediatricsNationwide.org/FSHD-antisense-RNAs
Modifying NK Cells With CRISPR/Cas9 Written by Mary Bates, PhD In a new proof-of-concept study, researchers used CRISPR/Cas9 technology to genetically modify natural killer immune cells, which they then showed are able to address a recognized hurdle in immunotherapy of multiple myeloma. PediatricsNationwide.org/NKCells-CRISPRCas9
Investigating Youth Suicides Among Children Involved With the Welfare System Written by Natalie Wilson To better understand and prevent suicide in this at-risk group, researchers at conducted the first study to compare characteristics and health service utilization patterns of youth suicide decedents (those who died by suicide) and non-decedents who were involved with the child welfare system. PediatricsNationwide.org/Youth-Suicide-Welfare
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PediatricsNationwide.org | Spring/Summer 2021
