CannaScience - Caryophyllene

The World of Cannabinoids &Terpenes

Caryophyllene is known as the spicy terpene with plenty of medicinal effects. As our research into the cannabis plant continues for this collum, we are discovering more about the many compounds that it contains, including over 100 different terpenes. One of the most intriguing and valuable terpenes found in cannabis is Caryophyllene.

Caryophyllene is a larger molecule compared to other terpenes like Limonene, which were featured in previous months. It is well-known for its spicy aroma and is often associated with the peppery note found in some cultivars of cannabis. Caryophyllene can also be found in black pepper, cinnamon, cloves, hops, and spices such as oregano, basil, and rosemary.

One of the most interesting things about Caryophyllene is that it is the first non-cannabinoid compound found to bind directly to neuroprotective cannabinoid receptors. Specifically, it binds to CB2 receptors, which makes it an ingredient in anti-inflammatory topicals and creams. Unlike other terpenes, Caryophyllene can activate CB2 receptors throughout the body.Caryophyllene has numerous potential health benefits, including relieving full-body pain, treating skin diseases, providing neuroprotective properties, reducing inflammation, and acting as an analgesic. Additionally, Caryophyllene has been shown to protect the cells that line the digestive tract, making it a potential ingredient in digestive health products.

One of the most promising areas of research for Caryophyllene is its potential use in alcoholism rehabilitation. Studies conducted on mice have found that this terpene can reduce voluntary intake of alcohol and may even be effective in treating alcohol withdrawal symptoms. In another study, researchers found that Caryophyllene caused multiple behavioral changes relevant to anxiety and depression in mice.

In conclusion, Caryophyllene is a powerful and valuable terpene found in cannabis and numerous other plants. Its unique ability to bind directly to endocannabinoid receptors makes it an essential ingredient in anti-inflammatory products, and its potential as a treatment for alcoholism and anxiety/depression is exciting. As research into the cannabis plant continues, we will likely discover even more about the many compounds it contains and the potential health benefits it may provide.

Caryophyllene Effects and Benefits:

Relieves full-body pain

Skin diseases

Neuroprotective

Anti-inflammatory issues

Analgesic

Protection of cells (the line of the digestive tract)

Anxiety and Depression

List of the high Caryophellen-rich cultivars:

Bubba Kush - This indica-dominant cultivar is known for its relaxing and sedative effects. It has a peppery aroma with hints of sweetness and earthiness.

Girl Scout Cookies - This hybrid cultivar has become incredibly popular in recent years due to its potent effects and sweet, earthy aroma. It is known to be high in Caryophyllene as well as other terpenes like Limonene and Linalool.

Sour Diesel - This sativa-dominant cultivar is famous for its energizing effects and diesel-like aroma. It is also high in Caryophyllene, which helps to provide anti-inflammatory and analgesic properties.

OG Kush - This classic cultivar has been around for decades and is known for its potent, relaxing effects. It has a unique aroma that is often described as earthy, woody, and spicy, which is due in part to its high Caryophyllene content.

Blueberry - This indica-dominant cultivar has a sweet, fruity aroma with notes of blueberry and earthiness. It is also high in Caryophyllene, which helps to provide its anti-inflammatory and analgesic effects.

Skywalker OG - This hybrid cultivar is a cross between Skywalker and OG Kush, resulting in a potent and relaxing experience. Thanks to its high Caryophyllene content, it has a spicy, earthy aroma with hints of sweetness.

Cherry Pie - This hybrid cultivar has a sweet, cherry-like aroma with earthy undertones. It is known to be high in Caryophyllene as well as other terpenes like Limonene and Myrcene, which provide a range of therapeutic benefits.

NOTE: the exact terpene profile of a cultivar can vary depending on the specific, farming practices, growing mediums & conditions as well as the genetics, so it's always a good idea to check with a reputable source such as the COA for specific information on a cultivars terpene content.

All information in this article is for educational purposes only. The information I've shared is derived from research gathered from external sources. Please check with your Cannabis Educated Primary Health Care Physician or Educated & Trained Cannabis Therapy Consultant before beginning any new diet or lifestyle change.

Written by Dr. Pepper Hernandez ND, Ph.D., CTC, CNHP in ECS & Naturopathic Medicine, Cannabis Therapy Consultant, The Founder and Education Director of the Cannabis Holistic Institute. To find out more about her Telemedicine Consultations, Educational Programs, YouTube videos, and other creative content, you can find her on the massive inter-webs on all platforms or at drpepperhernandez.com. Go forth, Go Cannabis..