Penn Dental Medicine Journal, Spring 2018 by Penn Dental Medicine

PDMJ PENN DENTAL MEDICINE JOURNAL | SPRING 2018

HISTORIC SPACE NOW STATE OF THE ART FORMER MAIN CLINIC TRANSFORMED THROUGHOUT TO THE ROBERT I. SCHATTNER CLINIC

FROM THE DEAN

Advancing on Many Fronts SINCE JANUARY OF THIS YEAR, I have been honored to serve as Interim Dean of Penn Dental Medicine. It has been a great pleasure working with the entire Penn Dental Medicine community to continue the excellence that has been achieved over the last several years. And starting in July, we are excited to welcome Dr. Mark Wolff as the new Morton Amsterdam Dean (see story, page 2); Dr. Wolff is coming to Penn Dental Medicine from the College of Dentistry at New York University, and we look forward to having him join the Penn Dental Medicine community. In the interim, I am pleased to report that Penn Dental Medicine is continuing to advance on many fronts. Within the area of clinical education and patient care, one of the School’s most iconic spaces — the former Main Clinic — opened in January as the Robert I. Schattner Clinic. This grand space has undergone a complete transformation and is now a state-of-the-art facility throughout (see story, page 10). Within the DMD academic program, we are enhancing our students’ experience in treating the youngest of patients — those children 5 years of age and under — thanks to a $1.53 million grant to our Divisions of Community Oral Health and Pediatrics (see story, page 20); and through faculty and alumni mentoring, we are working to support student wellness and engagement (see story, page 32). Additionally, in the area of research, Penn Dental Medicine continues to excel. In this issue, we highlight some of the School’s key research activities in 2017 — from high impact publications and grants activity to patent awards (see page 17).

Looking to the future, the University of Pennsylvania officially launched a new capital campaign — the Power of Penn — in April. The four-year campaign has a University-wide goal of $4.1 billion (see page 3). For its part, Penn Dental Medicine has a goal of raising an additional $20 million over the next four years to reach its overall $55 million campaign goal in support of research, scholarships, diversity, facilities, digital innovation, community programs, and general operations. The generosity of alumni, friends, corporate partners, and organizations has enabled the School to achieve so much over the past five years, when the quiet phase of this campaign began, and I’m confident their ongoing dedication to the School and its mission will continue as the campaign moves forward. Finally, as this academic year soon comes to a close, I want to extend my congratulations on behalf of the entire Penn Dental Medicine community to the Class of 2018. As these accomplished students graduate and move on to the next stage of their dental careers, they join a distinguished group of alumni. Congratulations to all!

Dana T. Graves, DDS, DMSc Interim Dean

INSIDE 10 2 9 16 17 24 29

Historic Space Now State of the Art

Former Main Clinic Transformed to the Robert I. Schattner Clinic

On Campus School News in Brief Faculty Perspective Views on Dental Topics & Trends Faculty Q&A Sharing Personal & Professional Paths Research Spotlight Translating Science to Practice Academic Update Department/Faculty News & Scholarship Alumni Highlights Profiles, Gatherings & Engagement

The First Five Years

An Innovative Grant Program Promotes a Holistic Approach to Treating Very Young Patients

Connecting, Advising

Faculty and Alumni Mentors Support Student Wellness and Academic Goals

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Class Notes News from Fellow Alumni

PENN DENTAL MEDICINE JOURNAL: Vol. 14, No. 2 University of Pennsylvania School of Dental Medicine www.dental.upenn.edu

In Memoriam Remembering Members of the Penn Dental Medicine Community

2018 Calendar Upcoming Events & Programs

Interim Dean: Dana T. Graves, DDS, DMSc Senior Associate Dean of Development and Alumni Relations: Elizabeth Ketterlinus Associate Dean for Leadership Giving: Maren Gaughan Director, Publications: Beth Adams Contributing Writers: Beth Adams, Amy Biemiller, Juliana Delany, Debbie Goldberg Design: Dyad Communications Photography: Mark Garvin, Halkin Mason Photography, Peter Olson Printing: The Pearl Group at CRW Graphics Office of Development and Alumni Relations: 215-898-8951

ON THE COVER: The School’s former Main Clinic has been renovated throughout; now the Robert I. Schattner Clinic, it features 74 operatories, outfitted with state-ofthe-art technology. Bathing the space in natural light is the wall of windows that line the north side of the clinic. (photo credit: Halkin Mason Photography courtesy of EwingCole)

Penn Dental Medicine Journal is published twice a year by the Office of Communications for the alumni and friends of the University of Pennsylvania School of Dental Medicine. ©2018 by the Trustees of the University of Pennsylvania. All rights reserved. The views expressed in this publication are not necessarily those of Penn Dental Medicine. We would like to get your feedback — address all correspondence to: Beth Adams, Director of Publications, Robert Schattner Center, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104–6030, adamsnb@upenn.edu.

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ONCAMPUS

SCHOOL NEWS IN BRIEF

Dr. Mark Wolff Named Next Dean of Penn Dental Medicine The University has named Dr. Mark Wolff as the next Morton Amsterdam Dean of Penn Dental Medicine; he will be assuming the new post July 1. The announcement was made in March by Penn President Amy Gutmann and Provost Wendell Pritchett. Dr. Wolff is a celebrated teacher, globally engaged scholar, and deeply experienced clinician. He is currently Professor and Chair of Cariology and Comprehensive Care at the College of Dentistry at New York University and also the College’s Senior Associate Dean for Development and Alumni Relations. “Mark’s career is notable for his commitment to superb clinical practice as well as excellence in scholarship, education, and community engagement,” President Gutmann said. “When we met Mark, he told us that he has always loved his work and believed in dental medicine because dentists help make people smile. We too are smiling at the prospect of Mark joining Penn and partnering with the incredible faculty, staff, students, alumni, and friends of Penn Dental Medicine to bring this storied school to even greater heights.” Since joining NYU in 2005, Dr. Wolff has brought bold and innovative thinking to the world’s largest dental school. As Chair of Comprehensive Care, he has led a diverse group of more than 400 faculty and staff with outstanding results; student pass rates on national boards are at near perfect levels and more than $20 million in research programs have been completed under his leadership. “Among Mark’s many successes,” Provost Pritchett said, “he has demonstrated the many ways in which integrating patient care, educational experiences, and research programs advance core strategic goals, strengthen faculty and student culture, and better link the mission of dental schools with local and global partners and communities.”

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Dr. Mark Wolff

At NYU, Dr. Wolff designed and implemented the world’s largest electronic dental-health record and fully digital imaging system. He has also increased interprofessional educational opportunities for NYU dental students by creating an integrated case seminar series that brings dental students together with students in dental hygiene, social work, nutrition science, and nursing. He led a school-wide initiative to emphasize duty, altruism, and community service as foundational components of the educational program. Also notable is Dr. Wolff’s commitment to local and global engagement. He developed a community-based educational program that assures each dental student an opportunity to work in underserved communities throughout New York and has also served the world’s most vulnerable patients with specially designed clinical programs for survivors of torture and other crimes against humanity.

As a faculty member at Stony Brook University for more than two decades before moving to NYU, Dr. Wolff revolutionized that institution’s dental-education program by pioneering a disease-based curriculum for firstyear students that focused on prevention and wellness alongside interventions and procedures. He also streamlined and strengthened patient care, including the design and adoption of the first 100 percent paperless clinical record at any dental school in the nation. A Fellow of the Academy of General Dentistry, Wolff has authored or co-authored 80 original articles as well as 20 books and chapters. Since beginning his career, he has also mentored more than 100 dental students in research who have presented 75 papers before the American Association and/or International Association of Dental Research. He has delivered invited lectures across the U.S. and the world and has received significant, long-term support for his scholarly activities, including from the National Institutes of Health, the Health Resources and Services Administration, and corporate and industry partners. He served as chair of the American Dental Education Association’s Council of Sections, as President of the American Association of Oral Biologists, and as both secretary and councilor of the American Association of Dental Schools’ Oral Biology and Cariology sections. The selection of Dr. Wolff concludes a global search to identify a successor to Interim Dean Dana Graves who has served in that role since January 1. “We express our great appreciation to Dana for his service in this vitally important role,” President Gutmann said. “Dana succeeded Denis Kinane whose dedicated leadership of Penn Dental Medicine from 2009 to 2017 contributed invaluably to the School’s eminence and sustainability in education, research, and clinical service.”

Power of Penn Capital Campaign Launches

The University of Pennsylvania officially launched a new capital campaign — the Power of Penn: Advancing Knowledge for Good — on April 12 with Penn President Amy Gutmann unveiling the goals and vision for the campaign to volunteer leadership at a special launch event. The four-year campaign, with a University-wide goal of $4.1 billion, will focus on raising resources to grow inclusion, spark innovation, and accelerate impact throughout Penn. All Penn schools and centers are part of the campaign. At Penn Dental Medicine, the Power of Penn Dental Medicine campaign will raise an additional $20 million of a $55 million campaign goal ($35 million raised in quiet phase) to support four key areas. They include building resources to: • propel breakthroughs in oral health and interdisciplinary discovery through fellowships and research support as well as professorships and other faculty needs;

• build unrestricted funds for vital operations within the School. Penn Dental Medicine’s campaign priorities received a boost during the campaign’s quiet phase, which extended from January of 2013 until December of 2017. During this period, more than $35 million was raised to complete the Thomas Evans Building transformation, expand scholarships, and secure the first of a fleet of four new PennSmiles buses. Leadership at the dental school will be working to raise the final $20 million to complete all projects by 2021. “We are grateful to the many alumni, friends, business partners, and organizations whose generosity has made it possible to invest in our students, faculty, and facilities,” says Senior Associate Dean for Development & Alumni Relations, Elizabeth Ketterlinus.

MOUs A memorandum of understanding (MOU), signed with other schools around the world, facilitates collaborative research and exchange with Penn Dental Medicine faculty and students.

MOUs ARE CURRENTLY ACTIVE WITH INTERNATIONAL SCHOOLS, INCLUDING:

22 MOUs with schools in Asia 11 MOUs with schools in Europe, 3 of which were new this academic year 4 MOUs with schools in South America 2 MOUs with schools in the Middle East, both new this academic year

GLOBAL SYMPOSIA

DENTAL MEDICINE

• produce the leaders of tomorrow through facilities improvements, digital innovation, scholarships, and funds to support diversity; • address unmet oral health needs of the community locally and globally and build support for additional community- and global-based programs;

Global Engagement: By the Numbers

GLOBAL SYMPOSIA WERE PRESENTED BY PENN DENTAL MEDICINE THIS ACADEMIC YEAR

in 5 different countries (Argentina, China, Mexico, Saudi Arabia, Taiwan) on the topics of biofilms/ microbiomes, endodontics, and periodontics.

The Power of Penn Dental Medicine CamADVANCING paign will KNOWLEDGE be led by Dr. William Cheung (D’81, FOR GD’82), Chair of the Penn Dental Medicine GOOD Board of Overseers, and Dr. David Shen (D’79), also on the Board. Dental Overseers Dr. Richard Copell (D’80) and Dr. David Tarica (D’83), who led fundraising during the campaign’s quiet phase, will continue as volunteer leaders for the new campaign. To learn more and to support the campaign, visit: www.dental.upenn. edu/powerofpenn. In addition, as part of the Power of Penn campaign, President Gutmann will be hosting regional events in the coming months to bring together alumni from all of Penn’s schools, including one in Washington, D.C. on June 12, in Boston on Oct. 2, in Los Angeles on Oct. 9, and in San Francisco on Oct. 11. For more on these, visit www.powerofpenn.upenn.edu

EXCHANGE STUDENTS International students spend two to four weeks at Penn Dental Medicine each year, attending selected classes and observing various clinical operations.

INTERNATIONAL STUDENTS VISITED THIS ACADEMIC YEAR

13 different universities and 9 countries (China, France, Japan, Peru, Spain, South Korea, Taiwan, Thailand, United Kingdom) were represented by the international students who visited this academic year.

INTERNATIONAL EXTERNSHIPS Fourth-year DMD students have the option of completing part of their hospital externships at sites across the globe.

STUDENTS DID INTERNATIONAL EXTERNSHIPS THIS ACADEMIC YEAR

9 different countries were included in this year’s extern sites (Botswana, China, England, France, Israel, South Korea, Taiwan, Thailand, Turkey)

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 3

ONCAMPUS

Dr. Uri Hangorsky Named Periodontics Interim Chair

Penn Dental Medicine has named Dr. Uri Hangorsky, Clinical Professor of Periodontics, Interim Chair of the Department of Periodontics. His appointment was effective in January 2018. A long-time member of the Penn Dental Medicine community, Dr. Hangorsky has been part of the School’s faculty since 1980, serving in a variety of teaching and administrative roles. Presently, he also serves as Associate Dean for Student Life, Admissions and the Program for Advanced Standing Students (PASS) — a post he will continue to hold along with his new appointment.

“With an extensive background in academics, his expertise in periodontics and respected leadership within Penn Dental Medicine, I am confident Dr. Hangorsky will successfully steer the Department of Periodontics through this time of transition,” says Interim Dean Dana Graves. Among the appointments Dr. Hangorsky has held at Penn Dental Medicine are Director of Predoctoral Periodontics, Associate Dean for Clinical Affairs, and Associate Dean for Academic Affairs. Recognized for his teaching, he was the recipient of Penn Dental Medicine’s Joseph L. T. Appleton Award for excellence in clinical teaching and the Graduate Periodontics Outstanding Teaching Award, and the University of Pennsylvania’s Provost Award for Distinguished Teaching. Dr. Hangorsky holds a DDS from Columbia University College of Dental Medicine and earned both an MSc and Certificate in Periodontics from Case Western Reserve University School of Dental Medicine. In addition to his academic career, Dr. Hangorsky also spent many years in private clinical practice limited to periodontics. Dr. Hangorsky will remain in the Interim Chair role until the search is complete for a permanent Chair.

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Schattner Pavilion Construction Nearing Completion

The legacy of the late Dr. Robert I. Schattner (D’48), one of Penn Dental Medicine’s most accomplished and devoted graduates, is continuing to move Penn Dental Medicine forward with the construction of the Schattner Pavilion on track for completion by mid-June. The Pavilion and the recent renovation of the School’s Main Clinic (now the Robert I. Schattner Clinic, see story, page 10) were both made possible through a $15 million gift from Dr. Schattner, made before his death last year. The Schattner Pavilion will build upon the unified Penn Dental Medicine campus achieved with the construction of the School’s Robert Schattner Center. When the Schattner Center opened in 2002, becoming the School’s main entrance, it linked the Thomas Evans Building and the Leon Levy Center for Oral Health Research. The Schattner Pavilion will enhance this connection, further joining all three buildings that make up Penn Dental Medicine and facilitating interaction among faculty, staff, and students within them. The 2,100-square-foot Pavilion will extend beyond the existing atrium of the Schattner Center and enclose a portion of the courtyard area behind it, creating a dynamic new space on two levels for public gatherings and interaction. The first floor space is intended to become a central meeting and reception area for faculty, staff, patients, and visitors to the Penn Dental Medicine campus. The second floor patient waiting area will improve wayfinding for patients being treated in the Schattner Clinic, situated on the second floor of the adjoining Evans Building. The second floor connection to the Leon Levy Center will provide a straight line of access from the Evans Building through the Schattner Center to Levy and open into a faculty collaboration space within Levy. The completion of the Schattner Pavilion is the culmination of a series of major facilities projects for Penn Dental Medicine since 2015, which in addition to the Robert I. Schattner Clinic that opened in January of this year, included the Evans Building Centennial Renaissance project that transformed all four levels of the School’s historic Thomas Evans Building.

On Board: Penn Dental Medicine Adds 5 Overseers Penn Dental Medicine is continuing to add to the depth and diversity of its Board of Overseers, welcoming five new members and bringing the Board’s total membership to 24. Their appointments to three-year renewable terms were officially approved by the University of Pennsylvania Board of Trustees this fall. Joining the Board are Dr. Joanne Chouinard-Luth (D’79); C. Mitchell Goldman (WG’75), Esq.; Larry L. Turner, Esq.; Ken Serota; and Sidney M. Bresler, Esq. A 1979 DMD graduate of Penn Dental Medicine, Dr. ChouinardLuth brings experience not only in dental practice but public health and nutrition as well, holding master’s degrees in each from the University of Illinois and Columbia University, respectively. In 2016, she also earned her chef certification from the Institute of Culinary Education in New York. Chouinard-Luth presently serves as CEO and Director of The John E. Luth and Joanne Chouinard-Luth Charitable Trust. Established by her and her husband, John Luth, the foundation is focusing its efforts on research and education of the public in issues of mitigation and prevention of chronic disease through exercise, diet, and improving local food environments. C. Mitchell Goldman brings extensive knowledge of health insurance and policy to the Board. A health care entrepreneur and health care transactional and reimbursement attorney, Goldman is currently CEO of Mid-Atlantic Dental Partners, a Philadelphia-area-based dental services organization. He has worked in wide ranging aspects of the health care industry including advising health care entrepreneurs in mobile health, accountable care organizations, dental support organizations, dental practice acquisitions, and dental supply companies. Goldman holds an MBA from Penn's Health Care Management program and a law degree from Temple University. Presently, he is also an adjunct professor of health care law at the Drexel University Thomas R. Kline School of Law.

Larry Turner joins the Board from the law firm of Morgan Lewis where he is a partner in its Labor and Employment Practice, co-lead of the firm’s Unfair Competition Task Force, and one of the original members of the firm’s Diversity Committee. Turner’s practice focuses on employment litigation, including restrictive covenants and trade secrets, cases involving anti-discrimination and wrongful termination claims, as well as nationwide Fair Labor Standards Act collective actions. A frequent speaker on employment-related topics, including enforcing non-compete covenants, independent contractor issues, and avoiding risks associated with diversity programs, he also counsels employers on litigation avoidance and best practices for corporate diversity initiatives. Turner holds a JD from Georgetown University Law Center. Also joining the Board is Ken Serota, President of Hu-Friedy, the Chicago-based dental instrument manufacturer. Serota has been affiliated with Hu-Friedy since 2004, when he was a member of the company’s advisory board. He went on to serve as Executive Vice President and CFO prior to being appointed President in 2011. In this current leadership post, he has been instrumental in identifying global growth opportunities, guiding new product development, instilling operational excellence and placing emphasis on digital innovation and transformation. An attorney and CPA, Serota was previously President and CEO of Liberty Group Publishing, and has held various executive level positions with a focus on mergers and acquisitions, business process optimization, and overall financial management.

And continuing to represent the legacy of the late Dr. Robert Schattner (D’48), a long-time Board member and alumnus, is Sidney Bresler, who presently serves as President and CEO of the Robert I. Schattner Foundation. Bresler oversees the overall operations and financial management of the recently formed Foundation. He is responsible for shaping the vision and mission of the Foundation; allocating capital; and developing and managing projects, partnerships and granting vehicles. Bresler, who holds a law degree, has more than 35 years of experience in investment management and real estate development and is active in a variety of philanthropic causes. At Penn, Overseers provide long- and short-term advice to deans and directors regarding the achievement of strategic objectives and priorities. Overseer boards serve as bridges between Penn's schools and centers and the community beyond campus boundaries. Although Overseers do not have fiduciary responsibility, Penn’s President, Provost and Board of Trustees rely heavily on the boards to help inform the work of the University’s schools and centers.

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ONCAMPUS DEVELOPING PROFESSIONALLY

STUDENT PROFILE: ROOPALI KULKARNI (D’19)

Focused on Making a Difference in the Lives of Others WHEN SHE WAS ONLY 7 years old, Roopali Kulkarni (D’19) started on a six-year journey of extensive dental interventions and what felt like a never-ending sequence of being fitted for appliances. “I went for years feeling unhappy about my smile and my appearance,” says Roopali. “I still remember the day my braces were removed. I glided by tongue along my teeth and grinned from ear to ear. I finally felt confident in myself.” Roopali’s new-found confidence as a young teen blossomed into a career epiphany. If dental work could make such a difference in her life, could she learn to do the same for others? “I knew then that I wanted to instill that same confidence in others and pursue a career in dentistry,” she says.

FOCUSING ON DENTISTRY AND PUBLIC HEALTH Before starting at Penn Dental Medicine, Roopali took a gap year and worked as a research assistant on a health literacy study – an opportunity that broadened her career aspirations. She learned the power that health care providers have in influencing and empowering patients to take better care of themselves and just how important the oral-systemic health connection is. “During that project, I conducted interviews with study participants to learn how older adults understand their own health and

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well-being,” she explains. “That interaction proved to me that I needed to establish good relationships with my patients in order to communicate effectively with them about their health and make a difference in their lives.” To help her better develop those interpersonal skills, Roopali decided to combine her studies in dentistry with public health. As a dual-degree candidate for a DMD and a master’s in public health, she is focusing on how public health and dentistry align through oral medicine. Through an internship working at Living Independently for Elders in West Philadelphia, her work in a community honors program, and an independent study project, she has developed a fondness for working with seniors. “I not only want to practice dentistry but want to provide specialized care to a geriatric population and medically complex patients,” she says. The dual-degree program is helping her meet that goal. “In dentistry we tend to focus on the millimeter, while in public health we focus more on the landscape. This dichotomy has allowed me to grow throughout the past three years in school and shown me how I can make a bigger difference as a dental professional,” she says.

While Roopali was attracted to Penn because of its inspiring people, unique energy, and academic rigor, she also found it a great fit for her outgoing personality — particularly with the opportunities available in the school’s American Student Dental Association (ASDA) chapter. ASDA is a national student-run organization that protects and advances the rights, interests, and welfare of dental students. It introduces students to lifelong involvement in organized dentistry and provides services, information, education, representation, and advocacy. “I have found my community in this association. It has provided me with lifelong friends, professional development, leadership opportunities, and the chance to engage with dental students and professionals from across the country,” she says. Roopali, who has recently been elected as the national president of ASDA, has also served on the national Board of Trustees as the District 3 Trustee, where she represents Penn and other regional schools by helping to plan programming that helps members better manage the issues affecting dental students and professional life. She was also selected to represent ASDA to the American Dental Association Advisory Committee on Annual Meetings. She is helping to plan the Association’s annual conference in Honolulu this October. “This has been a huge honor, and I hope to continue staying involved with organized dentistry post-graduation,” she says. “Dentistry is stronger when we all stand together and it’s important for students and practicing dentists to be involved, to lend our voices to important issues.”

LOOKING TO THE FUTURE With her third year at Penn Dental Medicine nearing completion, Roopali is excitedly looking forward to achieving her dream in dentistry. “Dentistry combines the best of all of my interests, skills, and passions, and I’m excited for my future,” she says. That future may also include making time to stay involved in academia. “I have had great mentors who have demonstrated their willingness to help me achieve my goals — I’d like to do the same,” she says. “As part of my career vision, I would love to serve as a part-time faculty member at a dental school and help guide the next generation of dental professionals and leaders.”

AADR TRAVEL AWARDS ADVANCING STUDENT RESEARCH EXPERIENCE

Through the School’s AADR Travel Awards, Penn Dental Medicine students and junior researchers had the chance to showcase their research on an international stage at the AADR/CADR Annual Meeting & Exhibition, March 21-24, 2018 in Fort Lauderdale. This was the fourth year for the Penn Dental AADR Travel Awards with 16 recipients participating in this year’s meeting (see list below). The AADR Travel Award program was launched by Penn Dental Medicine in 2014 to advance student /junior research, providing funds toward their travel to the annual AADR meeting where awardees have the opportunity to present their work. Recipients are selected by a faculty panel of judges at Penn Dental Medicine’s annual Research Day (the 2018 AADR Travel Award grants will be presented at Research Day 2018, May 10). The AADR Travel Awards are funded through the School’s Research Incentive Fund Committee with additional support from Dentsply Sirona and Johnson & Johnson. PARTICIPATING DMD STUDENT AWARDEES

Student/Project Saro Atam (D’18): Bond Strength and Nanomechanical Properties of Ozone Treated Dentin

Preceptor Fusun Ozer, Div. of Restorative Dentistry

Justine Chiou (D’19): The ESCRT Machinery is Recruited in KSHV Assembly and Egress

PARTICIPATING GRADUATE DENTAL EDUCATION STUDENT AWARDEES

Yan Yuan, Dept. of Microbiology

Student/Project Ibrahim Alkanfari (GD’19): Naturally Occurring Missense Variants of MRGPRX2 and their Effect on Mast Cell Function

Preceptor Hydar Ali, Dept. of Pathology

Jerry Choi (D’19): IKK-BETA Deletion in Mesenchymal Stem Cells Improves TGF-b Expression in Diabetic Fractures

Dana T. Graves, Dept. of Periodontics

Ting-Han Chang, (GD’20): The Role of Lgr5+ Stem-like Cells in Pathogenesis of Ameloblastoma

Anh D. Le, Dept. of Oral & Maxillofacial Surgery

Lansara Jaruthien (D’19): Role of SOX2 as a Downstream Effector in ESRP1- Induced Cleft Lip and Palate Formation in Mice

Hyun-Duck Nah, Dept. of Orthodontics

Andrew Henry (D’12, M’15, GD’18): Orbital Floor Fracture Repair with Polymerized 85:15 Poly(L-lactide-coglycolide) Implants

Helen Giannakopoulos, Dept. of Oral & Maxillofacial Surgery

Priyanka A. Patel (D’19): Regulation of Antimicrobial Peptide-Induced Mast Cell Responses by MRGPRB2 and B-ARRESTIN2

Hydar Ali, Dept. of Pathology

Kenneth Kufta (M’19, GD’22): A PreRadiation Dental Treatment Protocol for Head and Neck Cancer Patients

Neeraj Panchal, Dept. of Oral & Maxillofacial Surgery

Abby L. Syverson (D’19): Lineage Specific NF-KB Inhibition in MSCS Resolves Lymphocyte Trafficking in Diabetic Fractures

Dana T. Graves, Dept. of Periodontics

Da-Yo Yuh (GD’19): DEL-1, A Coupling Factor which Promotes Bone Regeneration during Resolution of Periodontitis

George Hajishengallis, Dept. of Microbiology

Marianne B. Vazquez (D’19): Investigating a Novel Mediator of the DNA Damage Response

Faizan Alawi , Dept. of Pathology

Bassam Zidane (GD’19): Effects of HIV Anti-Retroviral Drugs on Oligodendrocyte Differentiation via SREBP1 Pathway

Kelly L. Jordan-Sciutto, Dept. of Pathology; Judith B. Grinspan, CHOP

Thomas H. Yoo (D’18): Dental CBCT Investigation of Reported Pixel Values and Comparison to CT Number

Mel Mupparapu, Dept. of Oral Medicine

EDITOR’S NOTE: Just prior to publication, we learned that another postdoctoral student presenting at the AADR/CADR meeting, Yuan Liu, a DScD candidate and pediatric dentistry resident, was one of two winners in the prestigious AADR Hatton Awards Competition in the postdoctoral category. In addition, Justine Chiou (D’19) was among the finalists in the junior category of the Hatton Competition, and postdoctoral research fellow Dongyeop Kim was among the eight finalists in the AADR/CADR Joseph Lister Award for New Investigators. Chiou and Saro Atam (D'18) also were awarded 2018 AADR Bloc Travel Grants. Chiou, Atam, and Liu will present at the IADR meeting in London this July.

PARTICIPATING JUNIOR RESEARCHER AWARDEES

Researcher/Project Dongyeop Kim: Streptococcus mutansDerived Exopolysaccharides Enhance Antifungal Tolerance in Cross-kingdom Oral Biofilms

Research Lab Hyun (Michel) Koo, Dept. of Orthodontics & Divs. of Community Health/Pediatrics

Zhi Ren: A Dual-Targeting Antibiofilm Approach for EPS Matrix Degradation and Enhanced Bacterial Killing

Hyun (Michel) Koo, Dept. of Orthodontics & Divs. of Community Health/Pediatrics

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ONCAMPUS Upcoming CDE Spotlight Esthetic Dentistry

In June, Penn Dental Medicine will present two continuing education programs spotlighting esthetic dentistry — Advanced Esthetics Week, June 13-16, will feature leading experts on current techniques and technologies within esthetic dentistry, and on June 22, there will be a hands-on day of learning with master clinician Dr. Brian LeSage from Beverly Hills, Calif. Both programs will be held at Penn Dental Medicine and are being developed by the School’s Department of Preventive & Restorative Sciences. “The field of esthetics continues to rapidly evolve with the use of digital technologies and new materials,” says Dr. Markus Blatz, Professor and Chair of the Department of Preventive & Restorative Sciences and Assistant Dean for Digital Innovation and Professional Development. “We are pleased to not only share the work of international leaders in this area, but to provide a forum that facilitates an exchange among clinicians and educators working in the field across the country and around the world.”

ADVANCED ESTHETICS WEEK June 13-16, 2018 This four-day program will cover a wide range of topics within esthetic dentistry and includes three days of lectures and a day of hands-on workshops. Among the lecture topics will be esthetic analysis and the esthetic parameters for successful treatment planning; dental photography; a ceramics update; bonding protocols; surgical to restorative implant therapies; chairside CAD/ CAM dentistry; and digital full-arch solutions. The hands-on workshops will address surgical techniques, digital impressions, shade determination and finishing, and the use of zirconia.

MASTER CLINICIAN HANDS-ON COURSE A Day Spent Bonding with Composites: Contour, Color and Creativity Dr. Brian LeSage June 22, 2018 This hands-on course will explore the 3-D concept of color and contour as it relates to composite restorations. Through lecture and workshop exercises, participants will learn new techniques to improve composite artistry skills and how to create the nuances of natural enamel and dentin. Participants will improve their ability to create seamless restorations while maintaining the appropriate polish. Dr. LeSage is director of The Beverly Hills Institute of Dental Esthetics and a member of both the American Academy of Cosmetic Dentistry and the American Academy of Esthetic Dentistry. Learn more and register for both programs at www.dental.upenn.edu/cde.

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— FALL 2018 —

CDE SYMPOSIA

Penn Dental Medicine will also present two continuing dental education symposia this coming fall on the topics of dental microscopy and temporomandibular joint disease in the growing patient.

AMED-PENN DENTAL MICROSCOPY MEETING 2018 & 17TH ANNUAL MEETING & SCIENTIFIC SESSION OF THE ACADEMY OF MICROSCOPE ENHANCED DENTISTRY Details Matter September 28-30, 2018 This joint program with the Academy of Microscope Enhanced Dentistry (AMED) will feature world class clinicians in all branches of dentistry sharing the latest diagnostic and clinical techniques of dental microscopy. Along with lectures and live surgery, the program will include handson courses on both the basics of microscopy and advanced procedures using the microscope. AMED is an international membership association serving the dental profession and the public through teaching and research in the art and science of microscope enhanced dentistry.

PENN CENTER FOR TMJ DISEASE 2ND BIENNIAL SYMPOSIUM TMJ Disease in the Growing Patient December 8–9, 2018 This symposium is designed to guide the practitioner in the initial evaluation, diagnosis, and treatment of the pediatric patient with temporomandibular joint disease. Topics will focus on the growing facial skeleton, preventing disease progression, and recognizing distinct pediatric conditions affecting the TMJ. Speakers will utilize evidence-based diagnosis, treatment, and decision-making approaches to commonly encountered conditions in the growing patient. A multidisciplinary approach to these patients will be emphasized with speakers from pediatric rheumatology, oral and maxillofacial surgery, radiology, oral medicine, and orthodontics. Visit www.dental.upenn.edu/cde for a complete listing of upcoming continuing dental education programs. Penn Dental Medicine alumni receive discounted registration fees on most programs.

FACULTYPERSPECTIVE VIEWS ON DENTAL TOPICS & TRENDS

Chairside CAD/CAM Technology at Penn Dental Medicine CHAIRSIDE CAD/CAM (Computer Aided Design/Computer Aided Manufacture) technology provides dentists the possibility of delivering ceramic restorations in a single appointment. Among the patients’ benefits are the reduction of visits, avoiding unpleasant conventional impressions, and eliminating the need for a temporary restoration. With the implementation of intraoral scanners, the information from the abutment tooth preparation, opposing dentition, and interoccusal record can be obtained in a few minutes. The possibility of reviewing the tooth preparation in relation to adjacent and opposing teeth and detecting undercuts or irregular margins and surfaces, gives the practitioner a better understanding of the clinical situation to optimize the quality of the final restoration. As a result, definitive ceramic restorations with proper material thickness and natural contours can be designed and milled following a simple workflow. This provides less invasive treatment while preserving more healthy tooth structure.

Scan and design of single all-ceramic crown.

Hybrid-ceramic block and milling preview.

Try-in of same-day definitive restoration.

Proper understanding of the ceramic material used and its respective bonding protocols are crucial for long-term clinical success. Today, we have the possibility of milling different types of materials, such as hybrid ceramics, silica-based ceramics, and even zirconia for same-day delivery. Optimized ceramic furnaces for clinical use provide shorter crystallization and sintering times. With the implementation of longer and specific implant solution blocks, fixed dental prosthesis (FDP’s) and monolithic screw-retained implant-supported restorations as well as customized implant abutments bonded to titanium inserts can also be milled chairside. Clinicians who do not want to get involved in restoration design, milling, and finishing can also incorporate intraoral scanners into their practices and use the connectivity options to send their cases to a laboratory of choice. This digital option speeds up the elaboration process compared to traditional analogue methods and enhances communication between the clinician and laboratory technician, one of the most important aspects in restorative dentistry. When facing more demanding treatments, intraoral scanners are an excellent tool to capture and record patients’ initial conditions. In combination with a CBCT image, the patient’s Digital Clone can be evaluated and exported to an implant planning or surgical software. In-house fabrication of surgical guides is also a great benefit of this technology. Patients are delighted by the opportunity to receive their final ceramic crown, inlay, or onlay in one appointment. The frequent updates in CAD/CAM technologies, materials, and software requires constant training of our students, residents, and faculty to stay at the forefront and benefit from these innovations.

Contributed By: Dr. Julian Conejo Clinical CAD/CAM Director, Department of Preventive & Restorative Sciences As part of Penn Dental Medicine’s Digital Innovation Initiative, chair-side CAD/CAM technologies have been greatly accepted by faculty members and students. A focused teaching approach and newly developed “Train the Trainer’s programs” for faculty members and residents have been quite successful. Most important, however, the combination of traditional restorative concepts with the latest digital technologies provides our students with the best tools for their dental career.

Visit www.dental.upenn.edu/powerofpenn to learn more about digital dentistry initiatives that are part of the Power of Penn Dental Medicine campaign.

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 9

HISTORIC SPACE NOW STATE OF THE ART

FORMER MAIN CLINIC TRANSFORMED TO THE ROBERT I. SCHATTNER CLINIC ON JANUARY 2, 2018, the doors opened on a new era for Penn Dental Medicine’s storied Main Clinic when students, faculty, and staff welcomed patients to what is now the Robert I. Schattner Clinic and a state-of-the-art facility throughout. This 11,170-square-foot space has been the hub of clinical instruction and patient care since the School’s Thomas Evans Building opened in 1915 — heralded, at that time, for its advanced features and dramatic architectural elements, today, it can be as well. From the incorporation of computer-assisted design and manufacturing (CAD/CAM) technology and custom-designed operatories to the dramatic wall of windows, the space is designed for optimal educational and patient care experiences. “Within our Restorative Department, this facility is the stunning centerpiece of our comprehensive care clinics,” says Dr. Markus Blatz, Professor and Chair of the Department of Preventive and Restorative Sciences. “It is equipped to educate students and treat patients with the absolutely latest techniques and technologies, geared toward extensive integration of digital technologies, and readied to accommodate future developments.” The clinic renovation, completed over the past year, was made possible in large part through the generosity of the late Dr. Robert Schattner (D’48), an alumnus who contributed $15 million to this project and the new Schattner Pavilion that will be completed in June (see story, page 4). They culminate a series of major facilities projects for Penn Dental Medicine since 2015 as part of the Evans Building Centennial Renaissance project that transformed all four levels of the School’s historic Thomas Evans Building. “The Schattner Clinic truly is the crown jewel of the Evans Building renaissance,” says Dr. Mark Koup (D’04), Associate Professor of Clinical Restorative Dentistry and Director of Comprehensive Care Clinics; he and Dr. Patrice Ierardi (MT’80, D’84), Clinical Assistant Professor of Restorative Dentistry and Assistant Director of Comprehensive Care Clinics, oversee faculty, students, and the delivery of care in this clinic and the Edward & Shirley Shils Clinic, which opened in September 2016. Renovated by the Philadelphia-based architectural firm of EwingCole, the Schattner Clinic includes 74 operatories (four devoted to radiography), CAD/ CAM and wet laboratories off the west end, a faculty meeting area on the east end, a streamlined dispensing area on the south side, and a centrally located work station for clinic staff that provides a welcoming entryway for patients. “The Schattner Clinic has been universally well received and will have a positive impact on multiple levels related to the education of our students and patient care,” adds Dr. Najeed Saleh, Associate Dean for Clinical Affairs. “The modernized equipment will allow us to continue providing state-of-theart, patient-centered care with lower levels of patient anxiety due to the more soothing, welcoming nature of the clinic.”

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THOUGHTFUL DESIGN Creating a space that functions well for both teaching dentistry and treating patients was a top priority, and care was taken throughout the design process to achieve that goal. “This clinic was planned over several years with a vast amount of information and experiences from prior clinic renovations and other dental schools taken into consideration,” says Dr. Blatz, “including a great amount of input from our faculty and students.” Before final decisions were made on equipment and layout, Dr. Blatz explains that sample operatories were set up in the former Main Clinic so faculty and students could evaluate the ergonomics and share their preferences. A-dec equipment was ultimately selected, and among design qualities incorporated are the following.

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Ample room for 4-handed dentistry. The operatories are sized and equipment placed so students assisting, students providing care, and observing faculty can all work comfortably within the space. “The rearhand delivery system will allow for more effective four-handed dentistry and will enhance the experience during dental assisting,” says Dr. Saleh. Patient privacy & open site lines. The individual operatories provide patient privacy, yet were designed with glass panels on the upper portion to create open site lines that ease faculty supervision and student/faculty interaction.

Custom cabinetry. “We consulted with faculty and then worked with the vendor to custom design cabinets that would function well in our teaching environment,” says Dr. Koup. They feature two retractable shelves that can be repositioned in a variety of ways, a mount for the computer monitor that moves fully from one side to the other for flexibility in positioning, extra storage, and even a clock built into the front door. Within the operatories, the cabinets are positioned to allow for a comfortable amount of room behind the chair when providing care, while also being easy to access. “The cabinets also have outlets galore and USB ports,” notes Dr. Koup. “We added to the power capacity with an eye to accommodating equipment we may acquire in the future. It’s a forward thinking space designed for today and tomorrow.”

SCHATTNERCLINIC WELCOMING ENVIRONMENT ENHANCING PATIENT CARE A room with a view. Perhaps the most striking aspect of the Schattner Clinic is the abundance of windows, and thus, natural light. With a nod to the original architecture of the historic Evans Building, there are eight, 17 ½-foot windows on the north side of the clinic in the same footprint as the building’s original windows. In addition, original windows at the top of the south wall and a large bay window on the east end of the space were also revealed. Faculty, students, and patients alike agree the dramatic wall of

windows and bounty of natural light make it a positive environment for patient care. “The patients love coming here and that is the most important thing. They love all the light and the view out the windows,” says fourth-year student Frank Shannon (D’18). “I think it calms them, and if they are comfortable, it is much easier to work with them and provide care.” Dr. Koup also notes that the natural light is a benefit for shade matching and making decisions on restoration colors.

Peace and quiet. Another noticeable quality that makes the space welcoming is the low noise level. A major factor in creating a quieter environment is the switch to all electric dental handpieces. However, acoustic solutions were also incorporated into the design, including acoustic ceiling tiles to absorb high frequency sounds and 1,300 square feet of absorptive wall panels installed on the south side of the clinic to offset the hard surfaces of the large windows across the entire north wall of the clinic. (photo credit: pages 10–12 and bottom right by Halkin Mason Photography courtesy of EwingCole)

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SCHATTNERCLINIC

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SUPPORTING DIGITAL INNOVATIONS In terms of clinical instruction and stateof-the-art patient care, the Schattner Clinic is advancing the application of the latest technologies in digital dentistry. “The rapid advancement of digital dental technologies is changing restorative dentistry and prosthodontics like never before,” says Dr. Blatz, “and it is important that we expose our students to these technologies as early as possible.” The ABOVE: Dr. Mark Koup (D’04), Director of Comprehensive Care Clinics, and Dr. Patrice Ierardi (MT’80, D’84), Assistant Director of Comprehensive Care Clinics, consult with a student reviewing an intraoral scan taken with the mobile scanning units now used by DMD students in the new comprehensive care clinics. LEFT: (bottom right) The new CAD/CAM lab off the west end of the Schattner Clinic is outfitted with a chairside CAD/CAM milling machine and speed-fire furnace. (top right) Adding to patient services is a mobile checkout/payment station within the clinic.

resources within the Schattner Clinic are supporting that goal and the digital innovation initiative being implemented schoolwide. As part of Penn Dental Medicine’s progressive incorporation of digital workflow that includes digital radiography and digital patient records, all DMD students are now gaining exposure to intraoral scanning and chairside CAD/CAM technology. Mobile intraoral scanning units are available for chairside use within the Schattner Clinic and the CAD/ CAM lab on the west side of the clinic enables fabrication of same-day, milled restorations. The laboratory is outfitted with a chairside CAD/CAM milling machine capable of milling a wide array of restorative materials as well as a speed-fire furnace. “This is a new kind of furnace that enables us to use even the most current restorative materials, like zirconia, and mill and fire smaller restorations like crowns and onlays within hours,”

says Dr. Blatz. “So this lab is a convenient extension of our CAD/CAM Ceramic Center, which is geared toward fabricating larger and more complex dental restorations in a true laboratory setting.” “Having this CAD/CAM laboratory adjacent to the Schattner Clinic and in close proximity to the Shils Clinic enables us to practice this kind of dentistry more readily and conveniently, so it is a huge advantage,” adds Dr. Koup. “It is expanding our students’ exposure to this modality that they didn’t have before, so the clinic is changing the way our students are able to learn.” Third-year student Bret Lesavoy (D’19) agrees. “The clinic is awesome,” he says. “For us to see where we came from and where we are right now, it is exciting to see the school is placing so much emphasis on our clinical care experience.” — By Beth Adams

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FACULTYQ&A

SHARING PERSONAL & PROFESSIONAL PATHS

WHILE THE PENN DENTAL Medicine community may know the School’s faculty by the courses they teach, this Q&A faculty spotlight aims to get a bit more personal glimpse of them as individuals. For this issue, we talked with Michael Bergler, Director of the CAD/CAM Ceramic Center. He has been part of the School’s faculty since 2013.

technology. I got to know software developers and established contacts in the CAD/CAM industry for research and testing the latest digital equipment and my involvement with modern CAD/CAM technology just continued to grow. I love every aspect — software development, milling, digital workflow, material research, and of course, applying it all to patient care.

What have you found most rewarding about being a member of Penn faculty? First of all, I feel privileged to work in a profession that has been changing so dramatically. While CAD/CAM technology has been around for many years, the developments over the last five years have really affected the way we think in dentistry. Almost every month new materials, new software features, and new production technologies like 3D printing get introduced to the market. It’s rewarding as part of the faculty to be exposed to all these new developments and be on the cutting edge of digital technology. Sharing ideas with other faculty members and utilizing the latest digital tools with students to develop new treatment protocols gives unlimited opportunities for growth.

for Penn Dental. Being able to bring the latest technologies and concepts in digital technology to the School and being part of testing and developing new software applications and digital treatment concepts with different departments has been extremely rewarding.

What do you view as your greatest professional accomplishment? That is a difficult question. When I started as a dental technician in Germany, I was very proud of earning my master’s degree in dental technology at 24, as I was considered one of the youngest students to do so at that time. At 26, I gave my first lecture to the German Association in Implantology, and from that point on, got invited to other meetings first in Germany and then other parts of the world. Personally, it wasn’t about the speaking engagements, but rather realizing at a certain point that I could impact future generations in dental technology and be part of shaping a profession. Since coming to the U.S. in 2008, one of my greatest accomplishments has been being part of building and directing the CAD/CAM Ceramic Center

What drew your interest to your particular field and what do you enjoy most about it? There are many aspects of dental technology what drew my interest. When I first started, I was very focused on creating esthetic ceramic restorations. Since I worked at the University in Germany, I was also exposed to material research and implantology from the very beginning, and I realized how many interesting facets this profession has to offer. Implantology caught my interest; I was fascinated by the complexity and the many different options in designing an implant restoration. I was part of a highly specialized laboratory for implant restorations in Freiburg, Germany, but began to miss the research aspect and returned to the University of Erlangen, Germany in 2001. There I started to gain exposure to CAD/CAM

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Q&A with Michael Bergler

Director, CAD/CAM Ceramic Center

What advice from a mentor have you carried with you in your career? My first mentor, Prof. M. Hofmann, chairman of the restorative department of University of Erlangen, Germany, always told me: “Never stop questioning yourself and others” and “Theoretically gained results can never replace practical experience in restorative dentistry”. I still carry this advice and it has served me very well throughout my career. Schools/degrees? CDT, certified dental technician, University of Erlangen, Germany; MDT, master dental technician, Master School Freiburg, Germany; bachelor's and master's degrees, Germany. If you could have dinner with anyone who would it be? And why? As a guitar and rock enthusiast, I would have dinner with Slash, guitarist from the band Guns’n Roses. Actually, I would like to have dinner with the whole band. They all had to overcome all kinds of struggles; I think they’d have interesting stories to share. Hobbies? Playing guitar, live music, car racing, traveling, horseback riding, and since I came to the states, I’ve become a huge wine enthusiast. I recently finished the first wine courses to become a sommelier.

RESEARCHSPOTLIGHT TRANSLATING SCIENCE TO PRACTICE

Translating New Knowledge Scholarly Impact Across Disciplines The Penn Dental Medicine research enterprise spans scientific disciplines to translate new knowledge into clinical therapies that are expanding our understanding of disease and advancing patient care. In 2017, faculty and laboratory staff throughout our basic science and clinical departments continued to advance research and scholarship across their respective fields and beyond. Their commitment and passion for discovery are building on the School’s reputation as a leader in research and innovation. Here, we are pleased to highlight some of these research and scholarly activities for 2017.

The impact of faculty publications measured by the h index* is presented for a selection of research and clinical track faculty for the past five years. Career h-indexes are also included. RESEARCH TRACK FACULTY (Tenure/Tenure Track/Research Track) FACULTY

SCOPUS LIFETIME H-INDEX

SCOPUS 5 YR. H-INDEX

Dr. George Hajishengallis, Microbiology

Dr. Songtao Shi, Anatomy & Cell Biology

Dr. Henry Daniell, Biochemistry

Dr. Hyun (Michel) Koo, Orthodontics/COH/Pediatrics 43

Dr. Dana Graves, Periodontics

Dr. Claire Mitchell, Anatomy & Cell Biology

The top 10 funded Penn Dental Medicine researchers in fiscal year 2017 based on research grant activity.

Dr. Geelsu Hwang, Orthodontics

Dr. Gary Cohen, Microbiology

FACULTY/DEPARTMENT

FY17 TOTAL

Dr. Anh Le, Oral Surgery/Pharmacology

Dr. Kelly Jordan-Sciutto Pathology

$1,803,152

Dr. Shuying (Sherri) Yang, Anatomy & Cell Biology

Highly Funded Researchers

Dr. George Hajishengallis Microbiology Dr. Henry Daniell Biochemistry Dr. Michel (Hyun) Koo Orthodontics/COH/Pediatrics Dr. Dana Graves Periodontics

$1,411,120 $1,369,458 $1,117,107 $1,024,892

Dr. Kathleen Boesze-Battaglia Biochemistry

$947,362

D. Shuying (Sherri) Yang Anatomy & Cell Biology

$882,265

Dr. Gary Cohen Microbiology

$805,573

Dr. Claire Mitchell Anatomy & Cell Biology

$717,085

Dr. Hydar Ali Pathology

$676,135

CLINICAL TRACK FACULTY (Clinician-Educator/Academic-Clinician Track/Academic Support Staff) FACULTY

SCOPUS LIFETIME H-INDEX

SCOPUS 5 YR. H-INDEX

Dr. Markus Blatz, Preventive & Restorative Science

Dr. Betty Hajishengallis, Pediatrics

Dr. Fusun Ozer, Preventive & Restorative Science

Dr. Bekir Karabucak, Endodontics

Dr. Eric Stoopler, Oral Medicine

Dr. Frank Setzer, Endodontics

Dr. Thomas Sollecito, Oral Medicine

Dr. Jonathan Korostoff, Periodontics

Dr. Arthur Kuperstein, Oral Medicine

Dr. Rabie Shanti, Oral Surgery/Pharmacology

* The h-index was developed by J.E. Hirsch, Department of Physics, UCSD and attempts to measure the impact of an individual’s publications. As an example, an h-index of 20 means there are 20 publications that have 20 citations or more each in journals covered by the Scopus database.

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 17

RESEARCHSPOTLIGHT 2017 High Impact Original Articles: Clinical Sciences Within the School’s clinical departments, the following selection of original research articles with Penn Dental Medicine faculty as first or senior authors were published in 2017 in journals with high impact factors.* AUTHORS

ARTICLES

JOURNAL

IMPACT FACTOR

DEPARTMENT

Xiao E, Mattos M, Vieira GHA, Chen S, Corrêa JD, Wu Y, Albiero ML, Bittinger K, Graves DT

Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity.

Cell Host & Microbe

14.9

Periodontics

Corrêa JD, Calderaro DC, Ferreira GA, Mendonça SMS, Fernandes GR, Xiao E, Teixeira AL, Leys EJ, Graves DT*, Silva TA* (*co-senior authors)

Subgingival microbiota dysbiosis in systemic lupus erythematosus: Association with periodontal status

Microbiome

8.5

Periodontics

Hwang G, Koltisko B, Jin X, Koo H

Nonleachable Imidazolium-Incorporated Composite for Disruption of Bacterial Clustering, Exopolysaccharide-Matrix Assembly, and Enhanced Biofilm Removal.

ACS Applied Materials & Interfaces

7.5

Orthodontics/ COH/Pediatrics

Hwang G, Liu Y, Kim D, Li Y, Krysan DJ, Koo H

Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo.

PLoS Pathogens

6.6

Orthodontics/ COH/Pediatrics

Stoopler ET, Ojeda D, Alawi F

Asymptomatic Pigmented Lesions of the Gingiva.

JAMA Dermatology

5.8

Oral Medicine, Pathology

2017 High Impact Original Articles: Basic Sciences

Within the School’s basic science departments, the following selection of original research articles with Penn Dental Medicine faculty as first or senior authors were published in 2017 in journals with high impact factors.* AUTHORS

ARTICLES

JOURNAL

IMPACT FACTOR

DEPARTMENT

Chen C, Wang D, Moshaverinia A, Liu D, Kou X, Yu W, Yang R, Sun L, Shi S

Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis.

Cell Research

15.6

Anatomy & Cell Biology

Li Q, Xu K, Du T, Zhu P, Verma A, Kulkarni M, Prasad T, Daniell H

Oral Delivery of Angiotensin-(1-7) Bioencapsulated in Plant Cells Protect against Diabetes-Induced Tissue Damage and Retinopathy

Diabetes

8.7

Biochemistry

Jin SX, Singh ND, Li LB, Zhang XL, Daniell H

Engineered chloroplast dsRNA silences cytochrome p450 monooxygenase, V-ATPase and chitin synthase genes in the insect gut and disrupts Helicoverpa armigera larval development and pupation.

Plant Biotechnology Journal

7.4

Biochemistry

Fontana J, Atanasiu D, Saw WT, Gallagher JR, Cox RG, Whitbeck JC, Brown LM, Eisenberg RJ, Cohen GH

The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane.

MBio

7.0

Microbiology

Cairns TM, Ditto NT, Lou H, Brooks BD, Atanasiu D, Eisenberg RJ, Cohen GH

Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging.

PLoS Pathogens

6.6

Microbiology

*The Impact Factor identifies the frequency with which an average article from a journal is cited in a particular year. This number can be used to evaluate or compare a journal’s relative importance to others in the same field. Journal impact factors are reported in Clarivate Analytics InCites™ Journal Citation Reports®. The JCR, 2016, was used for these figures.

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2017 High Impact Review Articles

The following selection of review articles with Penn Dental Medicine faculty as first or senior authors were published in 2017 in journals with high impact factors.* AUTHORS

ARTICLES

JOURNAL

IMPACT FACTOR

DEPARTMENT

Hajishengallis G, Reis ES, Mastellos DC, Ricklin D, Lambris JD

Novel mechanisms and functions of complement.

Nature Immunology

21.5

Microbiology

Bowen WH, Burne RA, Wu H, Koo H

Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.

Trends in Microbiology

11.0

Orthodontics/ COH/Pediatrics

Zhang B, Shanmugaraj B, Daniell H

Expression and functional evaluation of biopharmaceuticals made in plant chloroplasts.

Current Opinion 7.9 in Chemical Biology

Biochemistry

Kwon K-C, Sherman A, Chang W-J, Kamesh A, Biswas M, Herzog RW, Daniell H

Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in hemophilia A mice.

Plant Biotechnology Journal

7.4

Biochemistry

Paula AJ, Koo H

Nanosized Building Blocks for Customizing Novel Antibiofilm Approaches.

J Dent Res

4.8

Orthodontics/ COH/Pediatrics

2017 New Grant Awards

FY17 Patent Awards

In 2017, the following new grants of $50,000 or more were awarded to Penn Dental Medicine.

The following patents were awarded to Penn Dental Medicine faculty in fiscal year 2017 as part of their research activities.

CLINICAL DEPARTMENTS Expanding Pediatric Training in Predoctoral Dental Education (See related story, p. 20) Principal Investigator: Dr. Joan Gluch, Professor and Division Chief, Division of Community Oral Health (Bureau of Health Professions/HRSA/DHHS; $1,528,175; 7/2017-6/2022) The Role of NF-kB in Mesenchymal Stem Cells During Diabetic Wound Healing Principal Investigator: Dr. Kang Ko from the lab of Dr. Dana Graves, Professor, Dept. of Periodontics (NIDCR/NIH/DHHS; $500,535; 7/2017-6/2022) Defining mechanical injury, hypoxia, and disease progression in TMJ OA and pain Principal Investigator: Dr. Eric Granquist, Assistant Professor of Oral & Maxillofacial (Oral and Maxillofacial Surgery Foundation; $75,000; 1/2017-12/2017) Stromal Cell-Derived IL-6 Promotes Stem-Like Cell Generation by Inducing Epithelial-Mesenchymal Transition in Ameloblastoma Principal Investigator: Dr. Qunzhou Zhang from the lab of Dr. Anh Le, Professor and Chair, Dept. of Oral Surgery/Pharmacology (Oral and Maxillofacial Surgery Foundation; $75,000; 1/2017-12/2017)

Expression of the Human IGF-1 Transgenic Plastids Inventor: Dr. Henry Daniell, Biochemistry Expression of human interferon in transgenic chloroplasts Inventor: Dr. Henry Daniell, Biochemistry Therapeutic Compositions for Bone Repair Inventor: Dr. Joseph Fiorellini, Periodontics Therapeutic Compositions for Bone Repair Inventor: Dr. Dana Graves, Periodontics Methods of Treating or Preventing Periodontitis Wound Diseases Associated with Periodontitis Inventor: Dr. George Hajishengallis, Microbiology

BASIC SCIENCE DEPARTMENTS Targeted Cultivation of New Periodontal Pathogens Principal Investigator: Dr. Flavia Teles, Associate Professor, Dept. of Microbiology (NIDCR/NIH/DHHS; $694,505; 9/2017-12/2018) Predicting Epitopes in Vaccine and Therapeutic Antibody Research Principal Investigator: Dr. Gary Cohen, Professor, Dept. of Microbiology (Carterra Inc.; $50,000; 2/2017-6/2018)

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“We are leading a new generation of dental health educators in treating the whole patient, not just their teeth.” — DR. JOAN GLUCH

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THE FIRST FIVE YEARS

AN INNOVATIVE GRANT PROGRAM PROMOTES A HOLISTIC APPROACH TO TREATING VERY YOUNG PATIENTS

THANKS TO A $1.53 MILLION GRANT from the U.S. Health Resources and Services Administration (HRSA), Penn Dental Medicine has announced a new focus on an important area of pediatric dentistry — care for children under the age of five. The grant includes supplemental funding for training in childhood obesity prevention, another area of critical need for American kids.

OPPOSITE: Dr. Joan Gluch (center) is the project director of the “first five” grant in conjunction with Dr. Betty Hajishegallis and Dr. Maria Velasco (to her left and right) of the Division of Pediatric Dentistry, who are helping to develop new educational modules and who supervise students working with children in the pediatric clinic.

Until now, Penn Dental Medicine students have had limited opportunities to care for children in this age group, who present some of the biggest behavioral challenges in pediatric dentistry. “There’s an old joke among dentists: If a two-year-old walks into a dentist’s office, who’s more afraid — the child or the dentist?” says Dr. Joan Gluch, Chief, Division of Community Oral Health and Project Director of the grant. “The reality is that most general dentists have not had a lot of training in dealing with very young patients, and yet all dentists will need to treat them at some point. Through this grant, all of our predoctoral students will now have clinical experience with children in their first five years of life.”

Penn Dental Medicine was one of 11 dental schools nationwide to receive the “firstfive” HRSA grant. By targeting the dental health of very young children as well as childhood obesity, the new curriculum promotes a holistic approach to pediatric dentistry. “We’re very proud that Penn Dental Medicine is at the forefront of this movement toward holistic dental care,” says Dr. Gluch, who applied for the grant in early 2017 in conjunction with the School’s Division of Pediatric Dentistry, led by Division Chief Dr. Betty Hajishengallis. “We are leading a new generation of dental health educators in treating the whole patient, not just their teeth.”

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FIRSTFIVEYEARS A SHORTAGE OF PEDIATRIC DENTISTS The dental schools that received the HRSA grant are mostly in urban and rural areas, which are less likely to have pediatric dentists, says Deanne Wallaert, a public health dental hygienist and educator who is helping to implement the program. In these areas, pediatric dental care usually falls to general dentists. “There are 67 counties in Pennsylvania, and 39 of them — about 60 percent — are without a pediatric dentist. Therefore, general dentists need to feel comfortable and confident in treating kids at all stages of development,” she says.

NEW LEARNING MODULES To bring about this goal, Penn Dental Medicine is instituting a two-pronged program consisting of new classroom learning modules and added rotations in the pediatric clinic and at community sites. The didactic, or classroom, portion of the curriculum includes eight new pediatric dentistry and public health learning modules for second- and third-year students that will address cultural competency, health literacy, social determinants of health, behavior management, oral health prevention, and restorative dental care. (A new module on childhood obesity prevention will be added in fall 2018.)

The lessons on cultural competency and social determinants of health are especially relevant to students working in a community as culturally and economically diverse as West Philadelphia. “Cultural competency” and “cultural humility” are two phrases health care leaders use to describe the importance of understanding and respecting a patient’s ethnic background and how it may affect health care expectations and decisions. In the case of young children, family values and attitudes are an important piece of the puzzle. Another key is the understanding of behavioral management in babies and toddlers, says Dr. Maria Velasco (D’10, GED’10), Assistant Professor of Clinical Pediatric Dentistry, who is helping to develop the new educational modules and supervises DMD students rotating through the pediatric clinic in conjunction with Dr. Hajishengallis. “An infant, a two-year-old, and a fouryear-old all present very different behavioral challenges to a dentist,” Dr. Velasco says. “An infant is usually examined on the parent’s lap, and students must earn to do a lap exam safely and effectively. A two-year-old might not want to sit still for treatment, whereas a four-year-old may have more fears. It’s important for the students to understand pediatric behavior at every age.”

EXPERIENCE IN THE CLINIC & COMMUNITY Case studies and treatment plans introduced in the classroom will come to life in the School’s pediatric clinic, where second-, third-, and fourth-year students will assist Penn Dental Medicine pediatric residents and attendings in examining “first-five” patients. Penn Dental Medicine will add about 1,000 advanced practice appointments to its pediatric clinical schedule for the 2018–19 school year, vastly expanding pediatric clinical opportunities for students. As always at Penn Dental Medicine, community outreach will be a cornerstone of the expanded pediatric curriculum. Second-year students will double their rotations at Penn-affiliated community health care sites, including Philadelphia FIGHT, Sayre Health Center, Homeless Health Initiative of the Children’s Hospital of Philadelphia, and Puentes de Salud. Through these clinical experiences, students will learn how to treat all kinds of young patients, including those with special physical, mental, or social needs, who may require a referral. “If a child has a cardiac condition and needs to have cavities filled, it may be imperative that he or she is referred to a specialist,” says Dr. Velasco. “Our students will learn when a referral is necessary for the safety and well-being of a patient.”

A KID-FRIENDLY APPROACH “It takes patience, flexibility, and persistence to treat young children,” says Wallaert. “It’s intimidating to try to brush someone’s teeth who is crying and screaming.” Through the new curriculum, students are learning to use games and role playing to make the process fun and help children relax. “Animal puppets with teeth and largescale toothbrushes are tools that can alleviate fears about going to the dentist, allow small children to feel more in control of their dental care, and educate them about their own teeth,” says Wallaert. “Letting a child count a puppet’s teeth is a natural segue into asking the patient to open wide so his or her own teeth can be counted.”

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mentals in the classroom and put them to use in the clinic and community setting. Penn Dental Medicine plans to make height and weight measurements a permanent part of each’s child’s dental chart and share guidelines on obesity with families at the dental visit. Students will also learn best educational practices in providing families with resources for healthy eating, exercise, and nutrition to encourage healthy behaviors. A child’s weight may be a sensitive subject, especially for low-income families who may have a hard time affording fresh foods and providing a safe outdoor exercise space, Wallaert says. “Again, we will be teaching students to understand the cultural and social determinants of health, and to have empathy for each family and their circumstances.”

EARLIER CARE PREVENTS CAVITIES Until fairly recently, parents were advised to schedule a child’s first dental appointment in preschool, but in recent years, dentists have seen the effectiveness of starting earlier. Normally, a child’s first tooth erupts between six months and a year, a great time for dentist and parent to discuss the need for brushing the new teeth after feedings and avoiding sugary foods and drinks to prevent cavities. “Early childhood caries is a huge problem in pediatric dentistry,” says Dr. Velasco. “Studies show that if a child receives five fluoride treatments by age three, the chance of tooth decay can be greatly reduced.” Early dental appointments often include what Dr. Velasco calls “anticipatory guidance” on a child’s future dental needs. “Is fluoride needed, and how much? What are the issues surrounding thumb sucking and pacifiers? Is drooling normal? We can discuss these questions with parents so they know what to expect as their child grows,” Dr. Velasco says. OPPOSITE: Hygienist Deanne Wallaert, who is helping to implement the program, with DMD students at a community site, where they worked with children in a Head Start program. (photos by Health Federation of Philadelphia) ABOVE: Dr. Maria Velasco, Assistant Professor of Clinical Pediatric Dentistry, (left) and a DMD student working with a young patient in the pediatric clinic.

“The reality is that most general dentists have not had a lot of training in dealing with very young patients...Through this grant, all of our predoctoral students will now have clinical experience with children in their first five years of life.” — DR. JOAN GLUCH

OBESITY PREVENTION: TREATING THE WHOLE PATIENT Late last year, Penn Dental Medicine received supplemental funding to include childhood obesity prevention as part of the educational and clinical activities in this project. In West Philadelphia, where as many as 45 percent of children are obese, the need for prevention training among all health care providers is great. In partnership with Dr. Terri Lipman and Amani Abdullah of Penn’s School of Nursing, Penn Dental Medicine is creating educational modules on obesity prevention training for predoctoral students to be introduced this fall. Nursing faculty will also work with Penn Dental Medicine faculty to design and implement clinical guidelines and educational programs regarding childhood obesity to be used with families in the pediatric dental clinic. Once again, students will learn funda-

PATIENTS AS PEOPLE As students embrace new opportunities for working with young children, Dr. Gluch and her colleagues are thrilled to deliver an expanded level of learning and experience in pediatric dentistry. Dr. Gluch plans to track the outcomes of the new instruction, which she believes will be sustainable far beyond the five years of HRSA funding. “Understanding our patients as people and learning how to tailor treatment to their specific needs,” she says, “is really what this new initiative is all about.” — By Juliana Delany

Visit www.dental.upenn.edu/powerofpenn to learn more about community initiatives that are part of the Power of Penn Dental Medicine campaign.

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 23

ACADEMICUPDATE

DEPARTMENT/FACULTY NEWS & SCHOLARSHIP

ANATOMY & CELL BIOLOGY

ENDODONTICS

MICROBIOLOGY

NEWS/ACHIEVEMENTS The 2018 Journal of Endodontics Award for the best clinical research publication in 2017 was presented to the following Department publication: Schloss T, Sonntag D, Kohli MR, Setzer FC. A Comparison of Two- and Three-dimensional Healing Assessment after Endodontic Surgery using CBCT Volumes or Periapical Radiographs. J. Endod. 2017. DOI:10.1016/j.joen.2017.02.007

SELECTED PUBLICATIONS

SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Gomez NM, Lu W, Lim JC, Kiselyov K, Campagno KE, Grishchuk Y, Slaugenhaupt SA, Pfeffer BA, Fliesler SJ, Mitchell CH. Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. Faseb J. 2017. Epub 2017/10/17. DOI: 10.1096/fj.201700220RR. Liu Z, Yuan X, Liu M, Fernandes G, Zhang Y, Yang S, Ionita CN, Yang S. Antimicrobial Peptide Combined with BMP2-Modified Mesenchymal Stem Cells Promotes Calvarial Repair in an Osteolytic Model. Mol Ther. 2018;26(1):199–207. DOI: 10.1016/j.ymthe.2017.09.011. Ota MS, Kondo K, Li Y, Iseki S, Yamashita A, Gibson CW, Kondo T. Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6. Biochem Biophys Res Commun. 2018. DOI: 10.1016/j.bbrc.2018.01.073.

ACCELERATED HEALING

Stem cell therapy shows promise for treating a variety of conditions but to optimize its use, researchers need to understand precisely how it works. Research from the lab of Dr. Songtao Shi, Professor and Chair of Anatomy & Cell Biology, has taken steps to nailing down how stem cells derived from gum tissue can speed wound healing. See the following article: Kou X, Xu X, Chen C, Sanmillan LM, Cai T, Zhou Y, Giraudo C, Le A, Shi S. The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing. Sci Transl Med. 2018 March 14. DOI:10.1126/ scitranslmed.aai8524

BIOCHEMISTRY SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Daniell H. PBJ publishes high-impact original plant biotechnology research with free global access. Plant Biotechnol J. 2018;16(1):3. Epub 2018/01/27. DOI: 10.1111/pbi.12877. Kwon KC, Sherman A, Chang WJ, Kamesh A, Biswas M, Herzog RW, Daniell H. Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in haemophilia A mice. Plant Biotechnol J. 2017. Epub 2017/11/07. DOI: 10.1111/pbi.12859.

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The Department presented a Penn Endodontic Global Symposium April 4–7, 2018, in Jeddah, Saudi Arabia, and will present another May 24–26, 2018, in Buenos Aries, Argentina.

SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Ahn SY, Kim NH, Kim S, Karabucak B, Kim E. Computer-aided Design/Computer-aided Manufacturing-guided Endodontic Surgery: Guided Osteotomy and Apex Localization in a Mandibular Molar with a Thick Buccal Bone Plate. J Endod. 2018. DOI: 10.1016/j.joen.2017.12.009. Burns LE, Visbal LD, Kohli MR, Karabucak B, Setzer FC. Long-term Evaluation of Treatment Planning Decisions for Nonhealing Endodontic Cases by Different Groups of Practitioners. J Endod. 2017. DOI: 10.1016/j.joen.2017.09.004. Kattan S, Lee SM, Kohli MR, Setzer FC, Karabucak B. Methodological Quality Assessment of Meta-analyses in Endodontics. J Endod. 2018;44(1):22–31. DOI: 10.1016/j.joen.2017.07.019.

A selection of recently published work by department researchers (indicated in bold). Belibasakis GN, Curtis MA, Hajishengallis G, Zaura E. Meeting report: The 12th European oral microbiology workshop (EOMW) in Stockholm, Sweden. Virulence. 2017:1–6. DOI: 10.1080/21505594.2017.1376147. Hajishengallis G, Lamont RJ. Metabolic nuclear receptors in periodontal host-microbe interactions and inflammation. Mol Oral Microbiol. 2017. Epub 2017/10/07. DOI: 10.1111/omi.12198. Hajishengallis G, Reis ES, Mastellos DC, Ricklin D, Lambris JD. Novel mechanisms and functions of complement. Nat Immunol. 2017;18(12):1288–98. DOI: 10.1038/ni.3858. Kajikawa T, Briones RA, Resuello RRG, Tuplano JV, Reis ES, Hajishengallis E, Garcia CAG, Yancopoulou D, Lambris JD, Hajishengallis G. Safety and Efficacy of the Complement Inhibitor AMY–101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017;6:207–15. DOI: 10.1016/j. omtm.2017.08.001. (Co-author from the Division of Pediatric Dentistry) Li Y, Zhong C, Liu D, Yu W, Chen W, Wang Y, Shi S, Yuan Y. Evidence for Kaposi sarcoma originating from mesenchymal stem cell through KSHV-induced mesenchymal-to-endothelial transition. Cancer Res. 2018;78(1):230–45. DOI: 10.1158/0008–5472.CAN–17–1961. (Co-author from the Department of Anatomy & Cell Biology) Liu D, Wang Y, Yuan Y. Kaposi's Sarcoma-Associated Herpesvirus K8 Is an RNA Binding Protein That Regulates Viral DNA Replication in Coordination with a Noncoding RNA. J Virol. 2018. Epub 2018/01/13. DOI: 10.1128/jvi.02177–17.

Chen LS, Kourtzelis I, Singh RP, Grossklaus S, Wielockx B, Hajishengallis G, Chavakis T, Mitroulis I. Endothelial Cell-Specific Overexpression of Del-1 Drives Expansion of Haematopoietic Progenitor Cells in the Bone Marrow. Thromb Haemost. 2018 Feb 7. doi: 10.1055/s0038–1624582. [Epub ahead of print]

TRAINING THE INNATE IMMUNE SYSTEM

The lab of Dr. George Hajishengallis in the Dept. of Microbiology collaborated with an international team to show how the innate immune system can be trained by altering bone marrow. See the following article: Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018;172(1–2):147–61.e12. DOI: 10.1016/j.cell.2017.11.034.

Liu SN, Hu J, Tan SH, Wang Q, Xu J, Wang Y, Yuan Y, Gu Q. Ent -Rosane diterpenoids from Euphorbia milii showing an Epstein-Barr virus lytic replication assay. RSC Adv. 2017;7(74):46938–47. DOI: 10.1039/c7ra08877a.DOI: 10.1189/ jlb.3MR0117–024R Teles FRF. The Microbiome of Periimplantitis: Is It Unique? Compendium of continuing education in dentistry (Jamesburg, NJ : 1995). 2017;38(8 Suppl):22–5. Epub 2017/12/12. Zhang T, Wu J, Ungvijanpunya N, Jackson-Weaver O, Gou Y, Feng J, Ho TV, Shen Y, Liu J, Richard S, Jin J, Hajishengallis G, Chai Y, Xu J. Smad6 Methylation Represses NFĸB Activation and Periodontal Inflammation. J Dent Res. 2018 Feb 1:22034518755688. doi: 10.1177/0022034518755688. [Epub ahead of print]PMID:29420098

Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G. Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88. Front Cell Infect Microbiol. 2017 Aug 8;7:359. doi: 10.3389/fcimb.2017.00359. eCollection 2017. PMID:28848717

RECENT GRANT AWARDS Targeted Cultivation of New Periodontal Pathogens The overall objective of this proposal is to recover and domesticate uncultured taxa associated with periodontal disease. Our central hypothesis is that their growth results from interactions with community members and the habitat, which have not yet been reproduced in vitro. Our rationale is that targeted systematic cultivation of relevant taxa in ex vivo biofilms is a cost-effective approach to isolate new periodontal pathogens. Funding Source: NIDCR/NIH/DHHS Principal Investigator: Dr. Flavia Teles, Associate Professor Predicting Epitopes in Vaccine and Therapeutic Antibody Research All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens; consequently, detailed characterization of antibody/ antigen binding can provide invaluable information to understand and guide development. Unfortunately, due to the time and expense required, atomic resolution structure determination is typically used sparingly, late in a development process or for a small number of different antibodies or antigen variants. We seek to enable earlier and larger-scale, but still detailed, characterization and modeling of antibody/antigen binding. Ultimately, the approaches developed here will allow researchers to leverage extensive epitope characterization data generated with Wasatch’s SPR instrument in order to broadly and deeply characterize the basis for antibody/antigen recognition in wide-ranging vaccine and therapeutic antibody discovery and development programs. Funding Source: Carterra Inc./NIH Principal Investigator: Dr. Gary Cohen, Professor

SELECTED PUBLICATIONS

ORAL MEDICINE

A selection of recently published work by department researchers (indicated in bold).

NEWS/ACHIEVEMENTS Dr. Eric Stoopler (D’99, GD’02), Associate Professor, was installed as President of the American Academy of Oral Medicine at the 72nd Annual Meeting of the American Academy of Oral Medicine, held in San Antonio, April 2018. He was also named to the 2018 cohort of Penn Fellows, which provides leadership development to select Penn faculty in mid-career. Dr. Stoopler and Dr. Thomas Sollecito (D'89, GD'91), Professor and Chair, served as editors of the January 2018 edition of Dental Clinics of North America focused on oral cancer. Other oral medicine, oral surgery, and pathology faculty from Penn Dental Medicine contributed.

Ahn PH, Finlay JC, Gallagher-Colombo SM, Quon H, O'Malley BW, Jr., Weinstein GS, Chalian A, Malloy K, Sollecito T, Greenberg M, Simone CB, II, McNulty S, Lin A, Zhu TC, Livolsi V, Feldman M, Mick R, Cengel KA, Busch TM. Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy. Photodiagn Photodyn Ther. 2018;21:28-35. DOI: 10.1016/j.pdpdt.2017.10.015. France K, Stoopler ET. The American Academy of Oral Medicine Clinical Practice Statement: Oromandibular dystonia. Oral Surg Oral Med Oral Pathol Oral Radiol. DOI: https://doi.org/10.1016/j. oooo.2018.01.023 Lingen MW, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D'Souza G, Gurenlian J, Kalmar JR, Kerr AR, Lambert PM, Patton LL, Sollecito TP, Truelove E, Tampi MP, Urquhart O, Banfield L, Carrasco-Labra A. Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity: A report of the American Dental Association. J Am Dent Assoc. 2017;148(10):712–27. e10. Epub 2017/09/30. DOI: 10.1016/j. adaj.2017.07.032.

Dr. Sollecito was honored by the Pennsylvania Dental Association (PDA) with its 2018 PDA Recognition Award. The award recognizes Dr. Sollecito’s clinical care, research, and teaching in the areas of oral mucosal diseases, head and neck tumors/cancer, TMD, and HIV dental treatment. Dr. Sollecito, Dr. Stoopler, and Dr. Martin Greenberg, Professor Emeritus, served on the Steering Committee for the 2017 World Workshop of Oral Medicine, held in, Glasgow, Sweden, this past fall. Dr. Farideh M. Madani (GD’78, GD’80, D’84), former Clinical Professor, who retired last year after more than 40 years of service, will receive the 2018 Penn Dental Medicine Alumni Award of Merit (see story, page 29).

Magill D, Beckmann N, Felice MA, Yoo T, Luo M, Mupparapu M. Investigation of dental cone-beam CT pixel data and a modified method for conversion to Hounsfield unit (HU). Dento maxillo facial radiology. 2018;47(2):20170321. Epub 2017/10/28. DOI: 10.1259/ dmfr.20170321. Mupparapu M, Creanga AG, Singer SR. Interpretation of cone beam computed tomography volumetric data: How to report findings? Quintessence Int. 2017;48(9):733–41. DOI: 10.3290/j. qi.a38906. Sadrameli M, Mupparapu M. Oral and Maxillofacial Anatomy. Radiol Clin North Am. 2018;56(1):13–29. DOI: 10.1016/j. rcl.2017.08.002. Stoopler ET, Aloyouny A, Greenberg MS. Uremic Leontiasis Ossea. Am J Med Sci. 2017 Nov;354(5):527. doi: 10.1016/j.amjms.2017.07.004.

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 25

ACADEMICUPDATE NEW RECENT GRANT AWARDS

ORAL CANCER DIAGNOSIS

Dr. Thomas Sollecito, Professor and Chair of Oral Medicine, was part of an expert panel charged with reviewing and updating the American Dental Association’s guidelines regarding oral cancer diagnostics. Biopsy remains the gold standard. See the following article: Lingen MW, Tampi MP, Urquhart O, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D'Souza G, Gurenlian J, Kalmar JR, Kerr AR, Lambert PM, Patton LL, Sollecito TP, Truelove E, Banfield L, CarrascoLabra A. Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association. J Am Dent Assoc. 2017;148(11):797–813. e52. Epub 2017/10/31. DOI: 10.1016/j. adaj.2017.08.045.

Stoopler ET, France K, Ojeda D, Sollecito TP. Benign Migratory Glossitis. J Emerg Med. 2018;54(1):e9–e10. DOI: 10.1016/j.jemermed.2017.09.035. Villa A, Akintoye SO. Dental Management of Patients Who Have Undergone Oral Cancer Therapy. Dent Clin North Am. 2018;62(1):131–42. DOI: 10.1016/j. cden.2017.08.010. Stoopler ET, Sollecito TP. Oral Cancer. Dent Clin North Am. 2018;62(1):ix–x. DOI: 10.1016/j.cden.2017.09.002.

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Outpatient Early Intervention Service with Respect to HIV Disease- Part C Oral health is an integral component of comprehensive HIV primary care. Access to oral health care remains an important aspect of overall health for HIV-infected individuals. Ryan White Part C-supported dental care services at Penn Dental Medicine are designed to be accessible to all adults with HIV/ AIDS, with particular focus on underand uninsured individuals. Funding Source: Drexel University/ DHHS/HRSA Principal Investigator: Dr. Thomas Sollecito, Professor

ORAL SURGERY/ PHARMACOLOGY NEWS/ACHIEVEMENTS Dr. Steven Wang (D’09, M’12, GD’15), Instructor, received the Student Research Training Award from the Oral & Maxillofacial Surgery Foundation. Chief Resident Dr. Andrew Henry (D’12, M’15, GD18) was awarded the OsteoScience Foundation Clinical Observership program with Dr. Michael Block and has also been accepted to an orthognathics/TMJ fellowship at the Carolinas Center for Oral and Facial Surgery with Dr. Brian Farrell after graduation. Resident Dr. Kenneth Kufta (M’19, GD’22) was re-elected as District II Representative for the resident organization of the American Association of Oral and Maxillofacial Surgeons.

SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Chung EL, Alawi F, Le AD, Shanti RM. Case Report: Virtual Surgical Planning and Piezoelectric Surgery in Tumor Extirpative Surgery Aimed at Inferior Alveolar Nerve Preservation. Case Reports in Surgery. vol. 2017, Article ID 4397178, 6 pages, 2017. doi:10.1155/2017/4397178. (Co-author from Dept. of Pathology)

Granquist EJ Treatment of the Temporomandibular Joint in a Child with Juvenile Idiopathic Arthritis. Oral Maxillofac Surg Clin North Am. 2018;30(1):97–107. DOI: 10.1016/j.coms.2017.08.002.

Mupparapu M, Shanti RM. Evaluation and Staging of Oral Cancer. Dent Clin North Am. 2018;62(1):47–58. DOI: 10.1016/j.cden.2017.08.003. (Co-author from the Dept. of Oral Medicine)

Kang S, Kufta K, Sollecito TP, Panchal N. A treatment algorithm for the management of intraoral burns: A narrative review. Burns. 2017. DOI: 10.1016/j. burns.2017.09.006. (Co-author from the Dept. of Oral Medicine)

Riegel R, Sweeney K, Inverso G, Quinn PD, Granquist EJ. Microbiology Alloplastic Total Joint Infections: A 20-Year Retrospective Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2018;76(2):28893. Epub 2017/11/28. DOI: 10.1016/j. joms.2017.10.027.

Kufta K, Forman M, Swisher-McClure S, Sollecito TP, Panchal N. Pre-Radiation dental considerations and management for head and neck cancer patients. Oral Oncol. 2018;76:42–51. DOI: 10.1016/j. oraloncology.2017.11.023. (Co-author from the Dept. of Oral Medicine) Kufta K, Saraghi M, Giannakopoulos H. Cardiovascular considerations for the dental practitioner. 2. Management of cardiac emergencies. Gen Dent. 2018;66(1):49– 53. Epub 2018/01/06.

Saraghi M, Golden LR, Hersh EV. Anesthetic considerations for patients on antidepressant therapy-part I. Anesth Prog. 2017;64(4):253-61. DOI: 10.2344/ anpr–64–04–14. Shanti RM, O'Malley BW, Jr. Surgical Management of Oral Cancer. Dent Clin North Am. 2018;62(1):77–86. DOI: 10.1016/j.cden.2017.08.005.

LOOKING AHEAD:

FALL 2018 SYMPOSIA AMED-Penn Dental Microscopy Meeting 2018 & 17th Annual Meeting & Scientific Session of the Academy of Microscope Enhanced Dentistry

Details Matter

SEPTEMBER 28-30, 2018 Penn Dental Medicine

Penn Center for TMJ Disease 2nd Biennial Symposium

TMJ Disease in the Growing Patient DECEMBER 8-9, 2018

Henry A. Jordan Medical Education Center Penn Center for Advanced Medicine Visit www.dental.upenn.edu/cde for a complete listing of upcoming continuing dental education programs. Penn Dental Medicine alumni receive discounted registration fees on most programs.

Thomas WW, Brant J, Chen J, Coblens O, Fischer JP, Newman JG, Chalian AA, Shanti RM, Cannady SB. Clinical Factors Associated With Reoperation and Prolonged Length of Stay in Free Tissue Transfer to Oncologic Head and Neck Defects. JAMA facial plastic surgery. 2017. Epub 2017/12/02. DOI: 10.1001/ jamafacial.2017.1771. Wang S, Giannakopoulos H, Lowstetter J, Kaye L, Lee C, Secreto S, Ho V, Hutcheson MC, Farrar JT, Wang P, Doyle G, Cooper SA, Hersh EV. Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa. Clin Ther. 2017;39(10):2103–8. DOI: 10.1016/j.clinthera.2017.08.017. Workman AD, Granquist EJ, Adappa ND. Odontogenic sinusitis: developments in diagnosis, microbiology, and treatment. Curr Opin Otolaryngol Head Neck Surg. 2018;26(1):27–33. Epub 2017/10/31. DOI: 10.1097/ moo.0000000000000430. Zhang Q, Nguyen PD, Shi S, Burrell JC, Xu Q, Cullen KD, Le AD. Neural Crest Stem-Like Cells Non-genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats. Mol Neurobiol. 2018:1–19. DOI: 10.1007/s12035–018– 0913–3.

NEW RECENT GRANT AWARDS Defining Mechanical Injury, Hypoxia, and Disease Progression in TMJ OA and Pain This research proposal lays the foundation to evaluate biomarkers of chronic TMJ disease and pain, as well as to define the early cellular mechanisms in the joint and nervous system associated with the development and maintenance of chronic orofacial pain. Funding Source: Oral and Maxillofacial Surgery Foundation Principal Investigator: Dr. Eric Granquist, Assistant Professor Stromal Cell-derived IL-6 Promotes Stem-Like Cell Generation by Inducing Epithelial-Mesenchymal Transition in Ameloblastoma Cancer stem cells constitute a unique subpopulation of cells within a tumor that may play a critical role in recurrence, relapse, and metastasis of malignancies. Epithelial-to-mesenchymal transition (EMT) is a fundamental process during development in multicellular organisms and also constitutes a

crucial step in the aggressive invasion and metastatic spread of a variety of epithelial tumors. This study will delineate the role of stromal cell-derived IL-6 in the regulation of EMT process and acquisition of stem-like cell properties in ameloblastoma epithelial cells and the underlying signaling mechanisms. The anticipated findings will substantially expand current knowledge regarding the EMT process and tumor stem-like formation in the pathogenesis of benign odontogenic tumors, thus potentially contribute to novel immunotherapeutic approaches for the treatment of malignant and benign tumors that are currently resistant to conventional therapies. Funding Source: Oral and Maxillofacial Surgery Foundation Principal Investigator: Dr. Qunzhou Zhang, Senior Investigator

ORTHODONTICS SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Bowen WH, Burne RA, Wu H, Koo H. Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments. Trends Microbiol. 2017. DOI: 10.1016/j.tim.2017.09.008. Chung C-H, Tadlock LP, Barone N, Pangrazio-Kulbersh V, Sabott DG, Foley PF, Trulove TS, Park JH, Dugoni SA. American Board of Orthodontics: Time for change. Am J Orthod Dentofacial Orthop. 2018;153:321–323. Cormode DP, Gao L, Koo H. Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials. Trends Biotechnol. 2018;36(1):15–29. DOI: 10.1016/j. tibtech.2017.09.006. Hwang G, Koltisko B, Jin X, Koo H. Nonleachable Imidazolium-Incorporated Composite for Disruption of Bacterial Clustering, Exopolysaccharide-Matrix Assembly, and Enhanced Biofilm Removal. ACS Appl Mater Interfaces. 2017;9(44):38270–80. DOI: 10.1021/ acsami.7b11558. Koo H, Allan RN, Howlin RP, Stoodley P, Hall-Stoodley L. Targeting microbial biofilms: Current and prospective therapeutic strategies. Nat Rev Microbiol. 2017;15(12):740–55. DOI: 10.1038/nrmicro.2017.99.

Liu Y, Palmer SR, Chang H, Combs AN, Burne RA, Koo H. Differential oxidative stress tolerance of Streptococcus mutans isolates affects competition in an ecological mixed-species biofilm model. Env Microbiol Rep. 2017. DOI: 10.1111/1758– 2229.12600.

Manorak W, Idahosa C, Gupta K, Roy S, Panettieri R, Jr., Ali H. Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1. Respir Res. 2018;19(1). DOI: 10.1186/s12931–017–0698–3.

Liu Y, Ren Z, Hwang G, Koo H. Therapeutic Strategies Targeting Cariogenic Biofilm Microenvironment. Advances in dental research. 2018;29(1):86– 92. Epub 2018/01/23. DOI: 10.1177/0022034517736497.

Rom S, Zuluaga-Ramirez V, Reichenbach NL, Erickson MA, Winfield M, Gajghate S, Christofidou-Solomidou M, Jordan-Sciutto KL, Persidsky Y. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: Implications for neuroinflammation. J Neuroinflamm. 2018;15(1). DOI: 10.1186/ s12974–018–1065–0.

Silvestre J, Basta MN, Fischer JP, Lowe KM, Mayro R, Jackson O. Minority and public insurance status: Is there a delay to alveolar bone grafting surgery? Cleft Palate-Craniofac J. 2017;54(1):e1–e6. DOI: 10.1597/15–173. Wen ZT, Liao S, Bitoun JP, De A, Jorgensen A, Feng S, Xu X, Chain PSG, Caufield PW, Koo H, Li Y. Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium. Front Cell Infect Microbiol. 2017;7:524. Epub 2018/01/13. DOI: 10.3389/fcimb.2017.00524. Xiao J, Huang X, Alkhers N, Alzamil H, Alzoubi S, Wu TT, Castillo DA, Campbell F, Davis J, Herzog K, Billings R, Kopycka-Kedzierawski DT, Hajishengallis E, Koo H. Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis. Caries Res. 2017:102-12. DOI: 10.1159/000481833. (Co-author from the Div. of Pediatric Dentistry)

Stern AL, Lee RN, Panvelker N, Li J, Harowitz J, Jordan-Sciutto KL, Akay-Espinoza C. Differential Effects of Antiretroviral Drugs on Neurons In Vitro: Roles for Oxidative Stress and Integrated Stress Response. J Neuroimmune Pharmacol. 2017:1–13. DOI: 10.1007/s11481–017–9761–6. Tanaka TI, Alawi F. Human Papillomavirus and Oropharyngeal Cancer. Dent Clin North Am. 2018;62(1):111–20. DOI: 10.1016/j.cden.2017.08.008. (Co-author from the Dept. of Oral Medicine)

PERIODONTICS NEWS/ACHIEVEMENTS Dr. Uri Hangorsky, Clinical Professor, and Associate Dean for Student Life, Admissions and the Program for Advanced Standing Students, has been named Interim Chair of the Department of Periodontics (see story, page 4)

Note: Koo H also has appointments in the Divs. of Community Oral Health and Pediatric Dentistry.

PATHOLOGY SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Boesze-Battaglia K, Walker LP, Dhingra A, Kandror K, Tang HY, Shenker BJ. Internalization of the active subunit of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon cellugyrin (synaptogyrin 2), a host cell non-neuronal paralog of the synaptic vesicle protein, synaptogyrin 1. Front Cell Infect Microbiol. 2017;7(NOV). DOI: 10.3389/fcimb.2017.00469. (Co-author from the Dept. of Biochemistry)

Effective October 2017, Dr. Howard Fraiman (GD’93, GD’94), Clinical Associate Professor, was named Director of Penn Dental Medicine’s Postdoctoral Periodontal Prosthesis Program. Dr. Stephen Hudis, Clinical Associate Professor, was appointed Vice President of the American College of Prosthodontists.

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ACADEMICUPDATE SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Chung JR, Choi JW, Fiorellini JP, Hwang KG, Park CJ. Effects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration. J Dent Anesth Pain Med. 2017;17(3):191–8. Epub 2017/11/02. DOI: 10.17245/ jdapm.2017.17.3.191. Dong G, Song L, Tian C, Wang Y, Miao F, Zheng J, Lu C, Alsadun S, Graves DT. FOXO1 regulates bacteria–induced neutrophil activity. Front Immunol. 2017;8(SEP). DOI: 10.3389/fimmu.2017.01088. Graves DT, Alshabab A, Albiero ML, Mattos M, Corrêa JD, Chen S, Yang Y. Osteocytes play an important role in experimental periodontitis in healthy and diabetic mice through expression of RANKL. J Clin Periodontol. 2018. DOI: 10.1111/jcpe.12851. Kinane DF, Stathopoulou PG, Papapanou PN. Predictive diagnostic tests in periodontal diseases. Nat Rev Disease Prim. 2017;3. DOI: 10.1038/nrdp.2017.70. Song L, Dong G, Guo L, Graves DT. The function of dendritic cells in modulating the host response. Mol Oral Microbiol. 2018;33(1):13–21. DOI: 10.1111/ omi.12195. Zhang C, Lim J, Jeon HH, Xu F, Tian C, Miao F, Hameedaldeen A, Graves DT. FOXO1 deletion in keratinocytes improves diabetic wound healing through MMP9 regulation. Sci Rep. 2017;7(1). DOI: 10.1038/s41598–017–10999–3. (Co-author from the Dept. of Orthodontics)

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PREVENTIVE & RESTORATIVE SCIENCES NEWS/ACHIEVEMENTS The Dept. of Preventive & Restorative Sciences will present Advanced Esthetics Week, June 13–16, 2018, at Penn Dental Medicine. This four-day program will cover a wide range of topics within esthetic dentistry (see story, page 8). Learn more at www.dental.upenn.edu/ advancedesthetics2018.

ADVANCED

ESTHETICS WEEK JUNE 13-16, 2018 SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Blatz MB. The 2nd Biennial IAAD Meeting. J Adhes Dent 2017;19(4):365–6. Conejo J, Kobayashi T, Anadioti E, Blatz MB. Performance of CAD/CAM monolithic ceramic Implant-supported restorations bonded to titanium inserts: A systematic review. Eur J Oral Implantol 2017;10:139–46. Conejo J, Nueesch R, Vonderheide M, Blatz MB. Clinical Performance of all-ceramic restorations. Current Oral Health Reports 2017;4(2):112–123.

RESIN BONDING & HIGHSTRENGTH CERAMICS: A CRITICAL REVIEW

The rise of computer-aided design (CAD)/computer-aided manufacturing (CAM) in clinical dentistry has also accelerated the use and popularity of high-strength ceramic materials — namely alumina and zirconia — for fabricating both tooth and implant-supported restorations. For successful clinical outcomes, the use of these materials has also raised questions about proper cementation and resin bonding protocols. In a recently published work in the Journal of Dental Research, Dr. Markus Blatz, Professor and Chair of the Dept. of Preventive & Restorative Sciences, and Dr. Julian Conejo, Clinical CAD/CAM Director, presented a literature review and discussion of the research evidence on resin bonding related to the clinical success of high-strength ceramic restorations, which has been a focus of Dr. Blatz’s research over the past 20 years. Among their conclusions, they note that while the studies showed high survival rates of porcelain-veneered alumina and zirconia fullcoverage crowns and fixed prostheses when inserted with conventional cements, most studies recommend resin bonding with composite resins or self-adhesive resin cements, particularly for implant-supported restorations, noting pretreatment and primers are needed. For the full review and discussion, see: Blatz MB, Vonderheide M, Conejo J. The Effect of Resin Bonding on LongTerm Success of High-Strength Ceramics. J Dent Res. 2018;97(2):132–9. DOI: 10.1177/0022034517729134.

Goodacre CJ, Blatz MB. Guest Editorial. Eur J Oral Implantol 2017;10 Suppl 1:3.

Irmak Ö, Yaman BC, Orhan EO, Ozer F, Blatz MB. Effect of rubbing force magnitude on bond strength of universal adhesives applied in self-etch mode. Dent Mater J 2018;37(1):139–45. Epub 2017/10/31. DOI: 10.4012/dmj.2017-018.

Division of Pediatric Dentistry Benadof D, Hajishengallis E, Cole A, Vidal C. Oral literacy demand in the pediatric dental clinic: a pilot study. Int J Paediatr Dent. 2017;27(5):326–33. DOI: 10.1111/ipd.12265.

Honda J, Komine F, Kamio S, Taguchi K, Blatz MB, Matsumura H. Fracture resistance of implant-supported screw-retained zirconia-based molar restorations. Clin Oral Implants Res 2017;28(9):1119–26.

Ozer F, Naden A, Turp V, Mante F, Sen D, Blatz MB. Effect of thickness and surface modifications on flexural strength of monolithic zirconia. J Prosthet Dent 2017. DOI: 10.1016/j.prosdent.2017.08.007.

Lindemeyer RG. Treating Bruxism in Children. Decisions in Dentistry, 4(2):53-56, 2018.

Irmak Ö, Yaman BC, Lee DY, Orhan EO, Mante FK, Ozer F. Flexural strength of fiber reinforced posts after mechanical aging by simulated chewing forces. J Mech Behav Biomed Mater 2018;77:135–9. DOI: 10.1016/j.jmbbm.2017.09.001.

Division of Community Oral Health Gluch, JI, Hexem, K. Effectiveness of Disease Prevention in Community Health Center Dental Programs. Current Oral Health Reports (2017) 4 (3): 169–175.

ALUMNIHIGHLIGHTS

PROFILES, GATHERINGS & ENGAGEMENT

2018 Alumni Awards The Penn Dental Medicine Alumni Society will once again recognize the accomplishments and dedication of alumni with its annual awards presentation. This year, the Thomas Evans Achievement Award, the highest alumni award; the Alumni Awards of Merit; and the Honorary Alumnus/ae Awards will be presented as part of Alumni Weekend 2018 at a special reception, May 11 at 4 pm. The following recipients will be honored.

THOMAS EVANS AWARD

The Thomas Evans Achievement Award is Penn Dental Medicine Alumni Society’s highest award of recognition, honoring alumni who have shown innovation, excellence, and leadership in the profession of oral health care nationally and internationally. This year’s recipient is: Dr. David Garber, GD’78, D’81 Dr. Garber, who earned both a DMD and postdoctoral certificates in periodontics and periodontal prosthetics at Penn Dental Medicine, is one of the managing partners of Goldstein, Garber and Salama dental practice in Atlanta, Ga., and presently is a Clinical Professor in both the Department of Periodontics and the Department of Oral Rehabilitation at the Medical College of Georgia School of Dentistry. He is also a Visiting Professor in the Department of Prosthodontics at Louisiana State University. Dr. Garber lectures extensively throughout the U.S., Europe, and Asia on multi-disciplinary approaches to optimizing esthetics. A past editor of the Journal of Esthetic Dentistry, he has published widely in the field and is currently completing a text on integrated therapy in advanced esthetics and the "esthetic implant.” Dr. Garber is a past president of the American Academy of Esthetic Dentistry (AAED) and a current board member of both the AAED and the American Academy of Fixed Prosthodontics.

ALUMNI AWARD OF MERIT

The Alumni Award of Merit recognizes love for and loyalty to Penn Dental Medicine, excellence in the profession of dentistry, and community involvement. The award acknowledges graduates who have maintained their ties with the School through their support of alumni activities, demonstrated leadership in the dental profession, and fostered and maintained the ideals of the School. This year’s recipients include:

Dr. Lee Carrasco, GD’02

Dr. Heywood Kotch, D’77

Dr. Farideh Madani, GD’78, GD’80, D’84

Dr. Margrit Maggio, D’87

HONORARY ALUMNUS/AE AWARD

The honorary alumnus/ae awards are presented to individuals who are not graduates of Penn Dental Medicine, but have demonstrated a strong commitment to Penn Dental Medicine through their service to and involvement with the School. This year’s recipients include:

Dr. Joan Gluch, PhD, RDH, PHDHP

Dr. Denis F. Kinane, BDS, PhD

Dr. Irving M. Shapiro, BDS, PhD

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ALUMNIHIGHLIGHTS

Alumni profile: Alan Atlas, D’86

Inspired to Deliver and Teach Exceptional Dentistry FOR A MAN ACCUSTOMED to international recognition, a recent handwritten letter has become a treasured reminder for Dr. Alan Atlas (D’86) that all the time, effort, and passion he puts in to inspire others in dentistry is well worth the sacrifice. The letter was from a veteran dentist of more than 40 years who attended one of Dr. Atlas’ lectures. It was addressed to Dr. Atlas’ family, thanking them for their sacrifices that allowed Dr. Atlas to share his message that each patient’s best interest is every dentist’s first priority. “The opportunity to affect the lives of my patients, my students, my colleagues, and their patients is not something I take lightly. My career has gone way beyond my expectations and I realize that it is because I have chosen to make exceptional patient care and service a huge part of my personal mission,” he says. Putting patients first has been a lifelong focus for Dr. Atlas. That focus has helped establish him as a trusted expert with patients, students, and colleagues. His private practice in comprehensive restorative and esthetic dentistry has helped thousands of people live healthier, more confident lives. As Clinical Professor of Preventive & Restorative

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Sciences and Endodontics with joint appointments in the Department of Preventive & Restorative Sciences and the Department of Endodontics at Penn Dental Medicine, he has inspired countless students in the practice of dentistry. And as an in-demand lecturer at professional meetings and conferences, he has enhanced the knowledge and acumen of colleagues nationwide. “Truthfully, I love what I do, and that has been my recipe for happiness and meaningful fulfillment and the reason I dedicate much of my time to teaching and lecturing,” he says.

INSPIRED BY HIS TIME LEARNING AT PENN DENTAL MEDICINE Sharing his passion for dentistry has deep roots in Dr. Atlas’ days as a student at Penn Dental Medicine. “As a dental student, I remember the day I obtained unexpected encouragement from one of my most demanding teachers — Dr. Bal Goyal. He demanded so much from all of us and drove home the imperative that details are important. The day that sticks in my mind is when he let me know that I had the clinical and communicative skills to make an impact on people’s lives through this profession,” he says.

That defining moment was brought to mind the first time he saw one of his students light up when they realized they could make that same impact. “Students absorb so much. It’s a true pleasure to work with them and help motivate them to be the very best they can be. That’s one of the reasons I teach,” he says. “When the knowledge dawns on them that they can make a true difference to each patient they work with, it’s energizing.” Lately, Dr. Atlas has seen a lot of those aha moments for students in the Endodontic-Restorative Microscopy and Technology Clinic, where he is co-director. This new clinical instruction initiative was recently launched to provide DMD students experience in using the dental microscope as a precision tool in restorative care along with digital technologies. “This is truly a unique training initiative that our students have enthusiastically embraced,” he says. Key to using technology for better patient outcomes are what Dr. Atlas calls his three pillars for success: doing dentistry well, motivating patients to higher levels of health, and using the right materials and equipment. “Easier and faster is not always better. It’s all in the detail and the precision of the practice,” Dr. Atlas says.

“Students absorb so much. It’s a true pleasure to work with them and help motivate them to be the very best they can be. That’s one of the reasons I teach.” — DR. ALAN ATLAS (D’86)

LOOKING AHEAD TO A NEW ERA IN DENTISTRY Since graduating from Penn Dental Medicine, Dr. Atlas (the 2006 Alumni Award of Merit winner) has witnessed a vast change in the practice of dentistry.

improve their ability to diagnose, plan treatment, and deliver optimal care. “Penn Dental Medicine is highly involved in ushering in this new era, with many leaders coming from and teaching at Penn,” he says. “I’m proud to be among these

“Penn Dental Medicine is highly involved in ushering in this new era [digital dentistry] with many leaders coming from and teaching at Penn.” “I graduated at the start of a tremendous renaissance in dentistry.” he explains. “At that time, adhesive, esthetic, and implant dentistry became a global phenomenon, with tremendous research that initiated a major shift in treatment planning and delivery of dental care.” Today, new digital technologies are bringing forward another era in dentistry, with exciting potential to help practitioners

outstanding colleagues and am continuously inspired by those who are fully committed to teaching the next generation of dentists.” Dr. Atlas hopes to connect with other alumni when he’ll be speaking at the 2018 American Dental Association annual session, as well as the Yankee Dental Conference, the Hinman Dental Meeting, and Chicago Mid-Winter meeting, all in 2019.

RETIRED FROM DENTAL PRACTICE? WHAT ARE YOU UP TO NOW? We would love to hear what you are up to after retirement from dental practice. Teaching? Mentoring? A second career? Share a bit of your story with us so we can share it with fellow alumni in future Penn Dental Medicine publications. Write to us at alumni@dental.upenn.edu.

The Right Asset Can Make Your Giving Better! Nurturing a great school like Penn Dental Medicine is a partnership between the School and the alumni who support it. Identifying the right asset can make the benefits of charitable giving even better. Retirement plan assets make some of the best charitable gifts because they may be highly taxed when left to a non-spouse, non-charitable beneficiary. But Penn Dental Medicine can receive these gifts free of taxes—and put more of your hard-earned dollars to work to advance excellence in dental education, research, and clinical care.

THE POWER OF PENN DENTAL MEDICINE

To learn more, contact: Elizabeth Ketterlinus Sr. Associate Dean Development & Alumni Relations Penn Dental Medicine 240 S. 40th Street Philadelphia, PA 19104 215.898.3328 ekett@upenn.edu www.powerofpenn.upenn.edu/gift-planning

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CONNECTING,

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ADVISING

FACULTY AND ALUMNI MENTORS SUPPORT STUDENT WELLNESS, ACADEMIC GOALS THIS YEAR FOR THE FIRST TIME, all first-year students at Penn Dental Medicine met one-on-one with Dr. Uri Hangorsky, Associate Dean for Student Life, Admissions and PASS, to go over their career options and plans, the opportunities and resources available at the school, and to discuss whether they would like to be matched with a faculty or alumni mentor. Although mentors previously have been available to students, this year there has been a renewed focus on encouraging students to connect with a mentor who can help provide advice, guidance, and support on a variety of academic, professional, and personal issues. It’s part of a broader effort, both at Penn Dental Medicine and the University of Pennsylvania, to focus on student wellness initiatives (see box on the right). “This school is a big place, and it’s helpful for students to have a faculty member or alumnus focused on their needs,” Dr. Hangorsky says. It’s also a way for students to interact more closely with specialists and practicing dentists and start to think about their career options. The need can vary by student. “Some students are children of dentists, their families are local and they have a large support system,” Dr. Hangorsky notes. “But many are far away from home, and the opportunity to interact with another individual in the same field, who they can talk to confidentially and ask for advice, is a huge boost. A mentor can be an advocate for the student.” The interactions between student and mentor will vary, but can include work shadowing, academic and career advising, social activities, research opportunities, professional networking and, often, a friendly and supportive person to talk to. OPPOSITE: (top left) Alumni mentor Dr. Shari Leavitt (D’87) with mentees Kristen Leong (D’21), seated, and Sujeong Lee (D’21). (bottom left) Dr. Uri Hangorsky talking with students. (bottom right) Faculty mentor Dr. Neeraj Panchal with mentees Jonathan Griffin (D’20) and Sarina Dodhia (D’20).

There has been a high level of interest this year in connecting with a mentor. Over the past three years, approximately 150 students in the DMD program have been assigned mentors, notes Sue Schwartz, Assistant Dean for Student Life. And while some students initially don’t seek out a mentor, they hear about positive experiences some of their classmates are having and come in later to request one. To facilitate a good match, students are asked if they prefer a faculty or alumni mentor and what their interests are, including career objectives, research, community service, honors programs or other areas. If they know where they want to live and work, students can be assigned alumni mentors who are working throughout the country or they can be matched with someone right here in the Philadelphia area. And while particular focus is on assigning mentors for freshmen, Dr. Hangorsky says students can come in any time during their studies to request a mentor. “Sometimes second- or third-year students may struggle, either didactically, clinically or emotionally, and we assign a mentor and that often turns things around.” For Sarina Dodhia (D’20), who has sought out mentors for school, dance, and sports in the past, requesting a mentor at Penn Dental Medicine didn’t give her a moment’s pause. “I have gained so much from this experience,” says Dodhia, who was paired with faculty mentor Dr. Neeraj Panchal her freshman year. “Guidance from an individual who has walked our path is invaluable and something we cannot obtain from a textbook or lecture.” The success of the mentoring program depends greatly on the faculty and alumni mentors, from a variety of specialties and geographic locations, who volunteer to help guide and support the students. Following are the experiences of two mentors and some of the students they have advised.

Student Wellness Programs/Resources With student wellness a critically important issue at Penn Dental Medicine and throughout the University of Pennsylvania, Penn Dental Medicine is continuing to develop a variety of resources and programming to promote student wellness. In addition to faculty and alumni mentoring, some of these resources include:

WELLNESS COURSES: Starting this year, students are required to take at least one wellness selective course of the five total selective credits required for traditional DMD students and the four credits required for PASS students. STUDENT CLUBS: Several student clubs offer wellness programs, including a wellness week sponsored by ASDA (American Student Dental Association). And the Office of Student Life organized a wellness event in April 2018 in collaboration with Penn’s Counseling and Psychological Services. FRESHMAN ORIENTATION INITIATIVES: An increased emphasis on wellness as part of freshman orientation was introduced for the 2016-2017 academic year, with additional programming added this year. FACE-TO-FACE MEETINGS with administrators where students can share concerns and learn about support resources: Morning coffee with the Dean: Initiated this March, students are invited to meet with Interim Dean Dana Graves for coffee and open-ended conversations Lunchtime Open Hours: The Office of Academic Affairs and Student Life has initiated a monthly lunchtime open hour for students to mingle and speak with staff. Monthly Town Hall Meetings: The Offices of Academic Affairs and Student Life host monthly meetings, open to all DMD students, as a forum for sharing concerns and facilitating discussions. COUNSELING AND PSYCHOLOGICAL SERVICES: A University counselor is available to meet with Penn Dental Medicine students three evenings a week, up from two evenings last year. UNIVERSITY-WIDE INITIATIVES INCLUDE: Wellness at Penn: This recently launched website provides a central spot for support, resources and practical tools on eight kinds of wellness at Penn, including emotional, physical, social, mental, sexual, spiritual, financial and occupational: www.wellnessatpenn.com. Take Your Professor/Mentor to Lunch & Faculty Hosted Dinner: To foster stronger professor/mentorstudent bonds, students can invite professors, teaching assistants, advisors or staff members for a free lunch at the University Club. And faculty members can host a class dinner in their home and be reimbursed per student by Penn.

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CONNECTINGADVISING

FACULTY MENTOR: DR. NEERAJ PANCHAL

r. Neeraj Panchal, Instructor, Department of Oral Surgery/Pharmacology, credits many of his own “amazing” mentors with motivating him to pursue a career in academic dentistry and oral surgery. Thus, he had no hesitation about paying this forward when asked if he was interested in mentoring Penn Dental Medicine students. In fact, in an abundance of enthusiasm, — JONATHAN GRIFFIN (D'20) he is currently mentoring nine first- and second-year Penn Dental Medicine students, taking time to meet them for dinner, providDodhia views Dr. Panchal as a mentor, ing insights into dental school and oral and academic and career advisor, and genermaxillofacial surgery, offering opportunities al sounding board on a variety of issues. to shadow in the clinic and operating room, “Knowing I have a mentor who is willing to as well as work on research projects. go above and beyond for me has positively “My goals for the program are quite simimpacted my well-being during these stressple, and that is to encourage our students to ful years in dental school,” she said. In terms have well-balanced personal and professional of career development, she says Dr. Panchal lives,” says Dr. Panchal, also Section Chief of provided an opportunity for her to write and Oral Maxillofacial Surgery for Penn Presbyterpresent two research papers on oral and maxian Medical Center. “We want to make sure our illofacial surgery and network with residents. students do well in all aspects of their lives.” Dr. Panchal, who also meets with several His dedication is apparent to his additional students each month who are mentees. When Sarina Dodhia (D’20) had interested in oral surgery careers, says in questions about whether to apply for the Readdition to providing educational and career search Honors Program last year, she texted guidance he tries to provide a comfortable Dr. Panchal on his cell phone, and just a few place for students to discuss their aspirations minutes later she received a call from him to and concerns and, sometimes, just vent. discuss the issue.

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“It was not too long ago that I went through the same hurdles that they are going through,” he says. “I know what it’s like to manage multiple classes, exams, clinical work, research, volunteer work and shadowing — besides all the other things in their lives.” He’s introduced mentees to private practitioners to gain insights and connected several students to colleagues serving as oral maxillofacial surgeons in the military. “I have a couple of students interested in military service, and their dedication and willingness to serve our country is an inspiration to me,” he notes. “Mentoring with Dr. Panchal has been a great experience,” says Jonathan Griffin (D’20), noting that every semester Dr. Panchal takes his mentees to dinner to catch up, talk about the ups and downs of school, and get to know each other on a personal level. Academically, Griffin is working with Dr. Panchal on a case report manuscript with the

“The insight and knowledge gained from Dr. Panchal has has helped me grow as a student both personally and professionally. Throughout the stresses of school, it is incredibly reassuring to know you have someone in your corner."

goal of having it published, and also hopes to shadow him on surgical procedures. “The insight and knowledge gained from Dr. Panchal has helped me grow as a student both personally and professionally,” Griffin says. “Throughout the stresses of school, it is incredibly reassuring to know you have someone in your corner.” And the benefits go both ways. “Mentorship is my favorite part of being in academic oral and maxillofacial surgery,” Dr. Panchal says. “The ability to develop relationships with trainees and help them pursue their dreams is a major reason why I am in academics.”

hen a Penn undergraduate interested in dentistry asked to shadow her back in 2011, Penn Dental Medicine alumna Dr. Shari Leavitt, (D ’87), didn’t hesitate. “It was so enjoyable,” she recalls. “She looked through my textbooks, came into the operatory with me to view fillings and extractions and learned about running a dental practice.” That student was Shin Young Ahn (D’16), who is now a full-time dentist in Dr. Leavitt’s practice, University Square Dental Associates, in West Philadelphia. “I wasn’t looking for an associate at that time,” Dr. Leavitt says, but has since found the addition of another dentist to her staff to be “life changing.” That positive experience has made Dr. Leavitt into somewhat of a “super mentor” among Penn Dental Medicine alumni. She estimates she has mentored more than 50 undergraduate and dental students since Dr. Ahn first reached out to her, many of them connecting through word of mouth or referred by the Penn Dental Medicine alumni office. The students have gone on to dental schools in New York, Boston, and San Francisco, among other places, including two currently enrolled in Penn Dental Medicine. Some of the students have worked as paid employees during gap years between college and dental school, while others have come for shorter periods of time to learn,

ALUMNI MENTOR: DR. SHARI LEAVITT (D ’87) for a year before starting at Penn Dental Medicine last fall. Besides providing experience in dentistry, Dr. Leavitt helped guide her through the dental school admissions process. It was the start of an ongoing and rewarding relationship. “She is not only a great career mentor, she is a great life coach as well,” Lee says. “I can talk to her about my personal struggles. I also feel that she genuinely believes in me

“She is not only a great career mentor, she is a great life coach as well. I can talk to her about my personal struggles. I also feel that she genuinely believes in me and that really motivates me to do my best."

Kristen Leong (D’21) started shadowing Dr. Leavitt as a Penn undergraduate, spending four hours a week at her office. “It gave me a lot of context for the things I’m learning.” In addition, she says Dr. Leavitt has helped her keep her perspective while in a challenging program, encouraging her to make time for relaxation and to take advantage of living in Philadelphia. For her part, Dr. Leavitt says she hopes to provide an honest accounting of what it’s like to be a dentist. “Dental school is not easy, practicing is not easy,” she notes, and says it gives her a good feeling to help guide and support the students. “I also enjoy their enthusiasm,” she says. “It brings me back to how excited I was to be in dental school.” — By Debbie Goldberg

— SUJEONG LEE (D'21) observe, and see if they are on the right career path. “I ask, ‘Can you foresee doing what I’m doing?’” says Dr. Leavitt, who exposes the mentees to dental care and procedures, explains basic restorative and dental terminology, and teaches them to read x-rays. “As much as they’re willing to absorb,” she says. Sujeong Lee (D’21) reached out to Dr. Leavitt as an undergraduate at Drexel University and ended up working in her office

and that really motivates me to do my best.” Technology can make it easy to stay in touch. Lee texts Dr. Leavitt if she has concerns or questions, and has sent photos of her first laboratory preparations. Dr. Leavitt says she’s been sent photos from students excited when they received their dental supplies, or showing her an amalgam they’ve done.

BECOME A MENTOR Interested in mentoring? Please contact Lindsay Murphy in the Office of Development and Alumni Relations at 215-8988023 or alumni@dental.upenn.edu and we’ll add you to the list of alumni we share with DMD and pre-dental students looking for a mentor. In the coming year, we are looking to evolve the program and find new ways to engage our alumni mentors.

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ALUMNIEVENTS ADA 2017 Penn Dental Medicine Alumni Reception at the ADA in Atlanta.

NETWORKING EVENT In October, the School held the 8th annual Alumni-Student Networking Event at the Ritz-Carlton Philadelphia. Over 160 alumni and students enjoyed making the connection at the annual fall event.

PENN DENTAL IN FLORIDA In February, Penn Dental Medicine hit the road in Florida making stops with Dr. Evans in Miami, Naples, and Tampa.

GREATER NEW YORK 2017 Annual Penn Dental Medicine Alumni Reception at the Penn Club of New York.

YANKEE DENTAL 2018 Penn Dental Medicine Alumni Reception at the annual Yankee Dental Conference in Boston.

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CLASSNOTES

NEWS FROM FELLOW ALUMNI

1940s Cynthia White Hamilton (DH’47) is the proud great-grandmother of three boys, who all live nearby. She is holding up well for 90 years old.

1950s

with the Veterans Administration in Northampton, Mass., but retired in 2011. Now, he and his wife enjoy traveling, spending time with family, and seeing old friends. Frederick Krochmal (D’68) recently celebrated 50 years of marriage. He is happily retired with four wonderful grandchildren.

Myron Schaffer (D’58) enjoys spending his winters in West Palm Beach, Fla., and summers in Syracuse, N.Y.

Matthew Mandel (D’68) just retired from an endodontic practice, and is spending his winters in Scottsdale, Ariz.

Evans “Bo” Guequierre (D’59) passed away April 3, 2017. He is survived by his loving wife, Verna Knowles Guequierre, and his brother, Jacques C. Guequierre. Bo practiced Orthodontics for 28 years at the University of Geneva Clinic, where he taught and rose to the professorial position of Chef de Traveau, or “Head of All Works.” Bo was loved by all who knew him, and he is sorely missed.

James McKelvey (D’68) is a guest lecturer to dental hygiene and other allied health students at Delaware Technical Community College, on the topic of “Skillful and Compassionate Communication in Health Care and in Life.”

1960s Fred Bergamo (D’64) retired after 50 years in practice. He had a wonderful and rewarding career, and would like to thank Penn Dental Medicine. Joseph ‘Buz’ Hanley (D’67, GD’69) and his wife Pat had two children while at Penn Dental Medicine, Chip and Michael. Dr. Hanley completed an oral surgery residency, and then served in the U.S. Army Dental Corps. Private practice in Hyattsville, Md., and Bristol, Conn., followed, and as an active reservist, he was recalled to active duty in 1991. After the military, he and Pat moved to the Berkshires. Dr. Hanley was on the teaching staff of the Berkshire Medical Center dental residency program for several years. He then took a part-time position as the oral surgeon

1970s The Lenape Regional High School District Board of Education honored William J. Bisignano, Jr (D’70) for serving on its board for 20 years. His dedication and hard work has led the district to great success. Dr. Bisignano still completely enjoys dentistry as a profession, and continues to serve as a full-time clinician in his Medford, N.J. practice. Steve Moriconi (D’78, GD’83) has been in private practice as an oral and maxillofacial surgeon since 1983. He has worked at Abington Jefferson Health since 1987, and serves as the Chief of the Dental Division and Program Director of the Abington GPR Program. He will soon be an official PDA lecturer for licensure CE on the opioid epidemic. Dr. Moriconi also runs a non-profit organization called “Men Anpil” for Haitian medical and dental students. He is happily married with six children and three lovely grandchildren!

Cary Limberakis (C’73, D’78) and his wife, Alexis, recently celebrated their 40th anniversary and couldn't be more proud of their four children. Over the last three years, Dr. Limberakis has experienced the joy of working alongside his son, Jonathan, in his practice in the Philadelphia suburbs. He has also enjoyed the camaraderie that comes with being involved in the ADA, at all its tripartite levels. He is currently serving on the Council on Dental Practice.

1980s After 34 plus years as a healthcare professional, a self-employed businessman, a vineyard operator (Pagoda Hill Vineyards, LLC), and many years of civic involvement on the Municipal Redevelopment and Parking Authorities, Gary Wegman (D’83) has decided to take the skills he’s learned and run for the 16th Congressional District House of Representatives seat in Pennsylvania in 2018. He thanks everyone who helped bring him to where he is today, and sincerely appreciates the support for his efforts on behalf of dentistry, his constituents, and the hope of creating a better tomorrow.

In addition to maintaining a private practice in dental implants and periodontics in Philadelphia, Robert A. Levine’s (GD ’84) busy 2017 included a whirlwind 29 lectures, with full-day courses at six dental schools and 14 full-day courses at national and international dental implant congresses and world symposiums. Evidence-based topics at venues like the International American Academy of Periodontology and International Academy of Periodontal Plastic Surgeons focused on several of Dr. Levine’s more recent publications including “10 Keys for Successful Esthetic Zone Single Immediate Implants” (Compendium, April 2017) and “Team Approach in a Full-Mouth Pro Arch Hybrid Reconstruction Using the Indirect Method for Provisionalization” (Compendium, May 2017). In addition, in January, Dr. Levine and his wife, Dr. Sheryl Radin, became the proud grandparents of Noah Ryan Levine. The baby’s parents are Dr. Ross Levine, a pediatric dentist at Growing Smiles in Yardley, Pa., and Abby (Perschon) Levine.

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 37

CLASSNOTES David P. Pitman (C’81, D’86) was Chair of the New York Section of the American College of Dentists, and completed a two-year term as a Trustee of the Northeastern Society of Periodontists in 2016. In the same year, he was named President of the South Orange New Jersey Board of Health after serving on the Board for 15 years. He is the former President of both the Columbia Dental and Periodontal Alumni Associations. This May marks the 30th anniversary of his graduation from the periodontics postgraduate program at Columbia University and 30 continuous years on the periodontics faculty. Most recently, Dr. Pitman was named President of the New York Academy of Dentistry, effective April 2018. Jeffrey Ganeles (GD’87) was appointed to Supply Clinic’s Advisory Board in October. Supply Clinic is an online marketplace for dental supplies founded by Scott Drucker (C’10, D’13) and his brother, Jacob. James Patrick Murphy (D’88) is proud to say that two of his eight children currently attend the University of Pennsylvania. Richard is a junior Biology major and Mary Rose is a freshman Electrical Engineering major.

1990s Luis J. Fujimoto (D’90, GD’93) is the president-elect for the American Association of Dental Boards (AADB) and vice-president for the New York County Dental Society (NYCDS). He is in the private practice of Comprehensive Dentistry with Advanced Services in Implants and Oral Rehabilitation in New York City.

2000s Elizabeth Prada (D’06) was promoted from Clinical Director to Executive Director of the Lancaster Cleft Palate Clinic. Dr. Prada was instrumental in founding the clinic’s Lime Street Pediatric Dentistry practice.

Bernard J. Costello (D’94, M’97, GD’00) has been named Dean of the School of Dental Medicine at the University of Pittsburgh, effective April 1, where he had been serving as Interim Dean since February of this year. He has been of the faculty at Pittsburgh since 2001 within the Department of Oral and Maxillofacial Surgery. He holds a secondary appointment as Professor in the medical school’s Department of Otolaryngology. Dr. Costello directed the residency program in oral and maxillofacial surgery until 2016, and he remains the fellowship director for pediatric craniomaxillofacial surgery. He has been Chief of the Division of Craniofacial and Cleft Surgery at the School and Chief of the Division of Pediatric Oral and Maxillofacial Surgery at Children’s Hospital of Pittsburgh of UPMC (CHP). Until 2016, he served as Director of Translational Research, and in that year, he was appointed to the position of Associate Dean for Faculty Affairs, followed by an appointment as Senior Associate Dean in 2017.

Share Your News Submit a Class Note to www.dental.upenn.edu/classnotes Or, you can send your submissions to: Robert Schattner Center Penn Dental Medicine Office of Development and Alumni Relations 240 South 40th Street Philadelphia, PA 19104–6030

38 WWW.DENTAL.UPENN.EDU

Elizabeth “Ellie” Baker (D’07) was sorry to miss her 10th reunion, but the past year has been very busy. She was honored to receive her recent FAGD award, but was even more proud to celebrate her 10 years of marriage to her husband Jon with her wonderful daughters, Eowyn and McKenna. Dana Romano (D‘08, GD‘13) married Joseph DiGerolamo on March 16, 2018 at St. Joseph’s Church in Hammonton, N.J. Dana practices as an associate pediatric dentist in Hamilton Square, N.J. Joseph is an animator/editor for Ogilvy and Mather in New York, N.Y. Jessica Bowen (D’08) was a member of the bridal party. The following Penn Dental Medicine alumni attended as guests: Lisa Shoff (D’08), Susan Kasper (D’08), Lisa Nguyen Hoang (D’08), Yolanda Madison (D’08), Banafsheh Vahid (D’08) Lucas Mantilla (D’09), Maria Velasco (D’10) and Pappy Chinna (D’10).

Julie Bharucha (D’13) was married on September 9, 2017.

Hector Sarmiento (GD’14) and Ana Kovacevic welcomed baby Luka Leonardo Sarmiento, 8lb , on March 10, 2018.

2010s Alex Volchonok (D’12) was recently recognized as a Fellow of the largest dental implant association in the world, the International Congress of Oral Implantologists. In addition to this prestigious honor, he also serves as a member and Diplomate on the American Board of Periodontology. Dr. Volchonok recently started his own New Yorkbased practice, AVPeriodontics, where he is dedicated to providing the highest level of periodontal care and patient experience.

Stephen Howarth (D’16) and his wife, Nicole, welcomed their first child, Stephen Howarth III, on September 17, 2017. Proud grandfather, Stephen Howarth (D’81) greeted the future Penn Dental Medicine graduate upon arrival.

INMEMORIAM

REMEMBERING MEMBERS OF THE PENN DENTAL MEDICINE COMMUNITY

Dr. Ricardo Teles The Penn Dental Medicine community warmly remembers Dr. Ricardo Teles, former Professor and Chair of the Department of Periodontics, who passed away in December. Having joined Penn Dental Medicine in August 2017, he quickly became a deeply valued member of the faculty and was highly regarded by students, colleagues, and alumni. Prior to coming to Penn, Dr. Teles was the OraPharma Distinguished Professor in the Department of Periodontology from 2014-2017 at the University of North Carolina School of Dentistry and Vice Chair of the Department from 2015-2017. He was also Senior Research Investigator in the Department of Applied Oral Sciences within the Center for Periodontology at The Forsyth Institute from 2014–2017 and Director of the Center from 2009–2010. An accomplished researcher, his work focused on the cause and treatment of periodontal diseases, and he was the principal investigator and co-investigator on many NIH-funded clinical trials focusing on the etiology and pathogenesis of periodontal diseases and the clinical and biological effects of periodontal therapies. Dr. Teles, a native of Brazil, earned a Doctor of Dental Surgery from the Federal University of Rio de Janeiro in 1988, as well as a Doctor of Medical Science and a Certificate in Periodontology from Harvard School of Dental Medicine in 1996. “Dr. Teles was an exceptional individual with a great passion for research and education,” says Interim Dean Dana Graves. “He was a widely respected colleague and educator, whose loss has impacted so many.” A tribute celebrating his life and contributions to the dental field was held at Penn Dental Medicine on April 23, 2018. His wife, Dr. Flavia Teles, is Associate Professor in the Department of Microbiology at Penn Dental Medicine.

Irving M. Rothstein (C’38, D’41) Rockville, MD; December 31, 2017

Philip L. Maloney (GD’59) Quincy, MA; November 16, 2017

Edward L. Sleeper (D’42, GD’51) Boston, MA; February 10, 2018

Peter H. Strife II (D’59) New York, NY; August 22, 2017

Lewis M. Pagano (C’41, D’43) East Brunswick, NJ; October 22, 2017

John E. Salem (GD’60) Ligonier, PA; October 11, 2017

William W. Flanagan, Jr. (D’51) Milford, DE; June 25, 2017

David S. Topazian (GD’60) Valencia, Venezuela; December 29, 2017

Anthony L. Checchio (GD’54) Philadelphia, PA; January 18, 2018 Ann Nelson Wilkins (DH’54) Basking Ridge, NJ; July 30, 2017

Ada Block Alpern (DH’62) Port Charlotte, FL; July 21, 2017 Robert H. Graeme (D’64) Allentown, PA; December 5, 2017

Cynthia D. Bornhuetter (DH’55) Blue Bell, PA; September 7, 2017

Anthony J. Pagano (D’65) Bryn Mawr, PA; November 28, 2017

Robert A. Greene, Jr. (D’55) Williamsburg, VA; November 21, 2017 Stanford E. Kane (C’53, D’56) Aventura, FL; January 14, 2018

Andre U. Buchs (D’66) Winter Park, FL; August 25, 2017 Charles G. Deutermann (D’70) Marathon, FL; September 29, 2017

Irving R. Spector (D’56) Valley Stream, NY; November 8, 2017 Francis Petruccelli (D’57) Schwenksville, PA; October 29, 2017 Irving Shuman (D’57) Coral Springs, FL; July 23, 2017

Kenneth W. Olsen (D’72) Hanover, NH; September 8, 2017 Thomas C. Leonard (D’73) Philadelphia, PA; October 23, 2017 Mark R. Eisner (D’77) Allentown, PA; January 6, 2018

Marilyn D. Shurilla (DH’57) Schnecksville, PA; November 6, 2017 John S. Eppolito (D’58) Clayton, NY; February 18, 2018

Scott R. Hall (GD’78) Tulsa, OK; August 26, 2017 James P. Herbert (D’82) Auburn, ME; February 9, 2018

Arnold Katz (C’55, D’58) East Rockaway, NY; December 22, 2017

Yi Zuo (D’00, GD’01) Philadelphia, PA; September 1, 2017

Evans C. Guequierre (D’59) Vero Beach, FL; April 3, 2017

Han Kyun Ko (D’07) Duluth, GA; January 1, 2018

William E. Holt (GD’59) Raleigh, NC; October 5, 2017

PENN DENTAL MEDICINE JOURNAL | SPRING 2018 39

2018CALENDAR

UPCOMING EVENTS & PROGRAMS

MAY

AUGUST

OCTOBER

NOVEMBER

MAY 8, 2018

AUGUST 13, 2018

OCTOBER 11, 2018

NOVEMBER 9–11, 2018

Senior Farewell The Bellevue, Philadelphia, PA

Class of 2022 White Coat Ceremony Annenberg Center for the Performing Arts

American Association of Oral and Maxillofacial Surgeons (AAOMS) Alumni Reception Chicago, IL

Homecoming Weekend University of Pennsylvania

MAY 10, 2018 Research Day 2018 Penn Dental Medicine MAY 11–12, 2018 Alumni Weekend 2018 Penn Dental Medicine

SEPTEMBER SEPTEMBER 18, 2018 Alumni Lecture Series CDE: Evidence Based Analgesia - Alternatives to Opioids Penn Dental Medicine

MAY 14, 2018 Commencement Irvine Auditorium

SEPTEMBER 28–30, 2018 CDE: AMED-PENN Dental Microscopy Meeting Penn Dental Medicine

JUNE JUNE 12, 2018

OCTOBER

Regional Campaign Celebration Washington, DC

OCTOBER 2, 2018

JUNE 13–16, 2018

Regional Campaign Celebration Boston, MA

CDE: Advanced Esthetics Week Penn Dental Medicine

OCTOBER 5, 2018

JUNE 22, 2018

CDE: Ortho Alumni Day Union League of Philadelphia

CDE Master Clinician Hands-on Course: A Day Spent Bonding with Composites – Contour, Color, and Creativity Penn Dental Medicine

OCTOBER 9, 2018 Regional Campaign Celebration San Francisco, CA OCTOBER 11, 2018 Regional Campaign Celebration Los Angeles, CA

40 WWW.DENTAL.UPENN.EDU

OCTOBER 18, 2018 Alumni Student Networking Event Ritz-Carlton Philadelphia OCTOBER 29, 2018 American Academy of Periodontology (AAP) Alumni Reception Vancouver, BC

NOVEMBER 16–17, 2018 CDE: Nitrous Oxide Certification Penn Dental Medicine NOVEMBER 26, 2018 Greater NY Alumni Reception The Penn Club, New York, NY NOVEMBER 26, 2018 Greater NY Young Alumni After Party Stout Flagship, New York, NY

Learn More... Visit www.dental.upenn.edu/events or call 215–898–8951 for information on alumni events. Visit www.dental.upenn.edu/cde or call 215–573–6841 for information on continuing dental education programs.

PENN DENTAL MEDICINE ALUMNI SOCIETY 2017–2018 EXECUTIVE COMMITTEE Eric Spieler, D’84 President Robert E. Weiner, C’72, D’79 Vice-President Members-at-Large Pam Alberto, D’80 Seyar Baqi, D’14 Judith Zack Bendit, DH’81 Hope Berman, C’77, D’83 Larry Chacker, D’85 Stefani L. Cheung, C’08, D’11 Gail Spiegel Cohen, C’76, D’80 Keith Dunoff, D’84 Lee B. Durst-Roisman, D’83 Wesam El Shafee, D’12 Charlene Fenster, DH’75 Marshall J. Goldin, C’60, D’64 Alyssa Marlin Greenberger, D’02 Mark Guevarra, D’16, GD’18 Wendy Halpern, D’99, GD’02, GD’03 JV Kracke, D’17, GD’19 Daniel Kubikian, D’01, GD’04, GD’05 Bernard Kurek, D’73, WMP’03 Rachel Levarek, D’11 Jeff Li, D’12 Helen Mo, D’16 Mana Mozaffarian, D’06 Ronald Pross, D’74 Michael B. Rulnick, D’74, GD’76 Trevan Samp, D’14 Matt Sones, D’12 Joseph Spina, D’02 Ann Eshenaur Spolarich, DH’82 Steven Ureles, D’83 Gary Wegman, D’83 Michael Yasner, C’79, D’83, GD’84, GD’86 Former Dean D. Walter Cohen, C’47, D’50 Ex Officio Member Dr. Jaclyn M. Gleber, DH’74

BOARD OF OVERSEERS

PDMJ ADVISORY COMMITTEE

William W. M. Cheung, D’81, GD’82, Chair, Power of Penn Dental Medicine Campaign Co-Chair Nancy Baker, Esq. Stanley M. Bergman, PAR’02 Sidney M. Bresler, Esq. Dirk Brunner Julie Charlestein Joanne Chouinard-Luth, D'79 Richard Copell, D’80 Matthew J. Doyle, PhD Patrik Eriksson C. Mitchell Goldman, WG'75, Esq. Anne E. Klamar, MD Anne L. Koch, D’77, GD’93 Madeline Monaco, PHD, MS, Med Haruo Morita Vincent Mosimann Lewis E. Proffitt, D’73, WG’80 Ken Serota Alfred L. Spencer, Jr. David Tai-Man Shen, D’79, GD’81, Power of Penn Dental Medicine Campaign Co-Chair David S. Tarica, D’83 Larry L. Turner, Esq. Umit Yigit, C’81, D’86 Robert Zou, WG’94

Beth Adams Director of Publications

Ex Officio Members Martin D. Levin, D’72, GD’74, Chair, Dean’s Council Eric Spieler, D’84, President, Alumni Society

DEAN’S COUNCIL Martin D. Levin, D’72, GD’74, Chair Robert Brody, C’80, D’84 Joseph Fiorellini, DMD, DMSc Howard P. Fraiman, D’91, GD’93, GD’94 Joseph E. Gian-Grasso, C’67, D’71 Elliot Hersh, DMD, MS, PhD Ronald T. Hwang, D’81 Brian Lee, D’00, GD’04 Saul M. Pressner, D’79 Howard Rosa, D’82 Louis Rossman, D’75, GD’77 Tony Saito, D’95 Gail E. Schupak, D’83 Tara Sexton, D’88 Robert M. Stern, D’87 Susan Stern, C’77, D’81 David Silver, D’85, GD’86, GD’88

Dr. Faizan Alawi Associate Professor of Pathology Associate Dean for Academic Affairs Dr. Markus Blatz Professor of Restorative Dentistry Chair, Department of Preventive & Restorative Sciences Corky Cacas Director of Admissions Sarah Burton Flynn Director of Alumni Relations & Annual Giving Maren Gaughan Associate Dean for Leadership Giving Dr. Joan Gluch Division Chief and Professor of Clinical Community Oral Health, Associate Dean for Academic Policies Dr. Dana Graves Professor, Department of Periodontics Vice Dean for Research and Scholarship Elizabeth Ketterlinus Senior Associate Dean of Development & Alumni Relations Dr. Robert Ricciardi Professor, Department of Microbiology Chair, Department of Microbiology Susan Schwartz Assistant Dean for Academic Services and Student Life Dr. Thomas Sollecito Professor of Oral Medicine Chair, Department of Oral Medicine

DEVELOPMENT & ALUMNI RELATIONS Elizabeth Ketterlinus, ekett@upenn.edu Senior Associate Dean of Development & Alumni Relations Maren Gaughan, gaughan@upenn.edu Associate Dean for Leadership Giving Sarah Burton Flynn sburton@upenn.edu Director of Annual Giving & Alumni Relations Lindsay Murphy, lhonzak@upenn.edu Assistant Director of Annual Giving Megan Connolly, megcon@upenn.edu Development Assistant Beth Adams, adamsnb@upenn.edu Director of Publications Office of Development & Alumni Relations 215–898–8951 Office of Continuing Education 215–573–6841

The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status or any other legally protected class status in the administration of its admissions, financial aid, educational or athletic programs, or other University-administered programs or in its employment practices. Questions or complaints regarding this policy should be directed to the Executive Director of the Office of Affirmative Action and Equal Opportunity Programs, Sansom Place East, 3600 Chestnut Street, Suite 228, Philadelphia, PA 19104–6106; or (215) 898–6993 (Voice) or (215) 898–7803 (TDD).

Non-Profit Org. U.S. Postage PA ID Permit No. 2563 Philadelphia, PA

Robert Schattner Center University of Pennsylvania School of Dental Medicine 240 South 40th Street Philadelphia, PA 19104–6030

LOOKING AHEAD:

ADVANCED

FALL 2018 SYMPOSIA

ESTHETICS WEEK

AMED-Penn Dental Microscopy Meeting 2018 & 17th Annual Meeting & Scientific Session of the Academy of Microscope Enhanced Dentistry

Details Matter

SEPTEMBER 28-30, 2018 Penn Dental Medicine

SAVE THE DATE JUNE 13-16, 2018

Penn Center for TMJ Disease 2nd Biennial Symposium

TMJ Disease in the Growing Patient DECEMBER 8-9, 2018

University of Pennsylvania | Philadelphia USA

Henry A. Jordan Medical Education Center Penn Center for Advanced Medicine COURSE DIRECTOR Markus B. Blatz FEATURED SPEAKERS Michael Bergler | Markus B. Blatz | Julián Conejo Enrique Díaz Guzmán | Sean Han | Arturo Llobell

Connect with us online!

Visit www.dental.upenn.edu/cde for a complete listing of upcoming continuing dental education programs. Penn Dental Medicine alumni receive discounted registration fees on most programs.