Perkins Eastman: Biotechnology & Life Science Brochure

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&BiotechnologyLifeScience

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DESIGN can have a direct, positive impact on people’s lives. We design places and spaces that put the user at the heart by employing best practices, sustainability, and a thorough understanding of our clients’ missions and operations. Our diverse teams partner with our clients globally to deliver next-generation projects that are uniquely suited to users who will live, work, play, learn, age, and heal within the environments we plan and design.

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4 PERKINS EASTMAN BIOTECHNOLOGY LABS Our staff has touched over countries We have won over awards for design excellence We have communities worldwide We speak over languages 24 8504140

Our diverse team is composed of a talented and creative group of architects, interior designers, planners, engineers, urban designers, landscape architects, graphic designers, construction specialists, economists, researchers, strategists, programmers, data analysts, environmental and resiliency experts, and many other professionals and practitioners which differentiates us as a firm. We are one community, and our collaborative culture allows us to work across disciplines to promote new ideas and dialogue to the design process.

Firm Profile

PERKINS EASTMAN IS A GLOBAL DESIGN, PLANNING, AND CONSULTING FIRM. OUR TEAM OF OVER 1,100 PROFESSIONALS IN 24 OFFICES ARE BOUND WITH THE VISION THAT DESIGN SHOULD HAVE A DIRECT AND POSITIVE IMPACT ON PEOPLE’S LIVES. Through each of our 20 core practice areas, we design for a sustainable and resilient future, and to enhance the human experience through the built environment.

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Our global presence enables us to leverage our firmwide expertise with local delivery through a collaborative design process. Shaping our environment for a more resilient future, we are designers of cities, schools, hotels, residential, offices, health and wellness centers, sports and exhibition venues, retail and entertainment venues, our convergence of expertise and creative process is what makes our firm unique.

20 Ashburton Place Floor Boston,8 MA 02108

Dallas

Philadelphia 1216 Arch Street Suite Philadelphia,800 PA 19107

Forbes Building, Floor 5 Charanjit Rai Marg, Fort, Mumbai, Maharashtra 400 001

Washington DC One Thomas Circle NW Suite Washington,200 DC 20005

Providence 225 Dyer Street Second Providence,FloorRI 02903

T. +1 215 563 3900

T. +1 512 200 7332

T. +1 919 351 6100

Costa Mesa

Los Angeles

Dubai Marina Plaza, Level 8 PO Box 212763, Dubai Marina, Dubai, UAE T. +97 143433632

T. +1 416 506 1500

3194 D Airport Loop Drive Costa Mesa, CA 92626

New York 115 Fifth Avenue New York, NY 10003

Boston

T.India+91 22 6903 9500

T. +86 2162521040

Guayaquil

Toronto 247 Spadina Avenue Suite Toronto,400ON M5T 3A8

The Rookery 209 South LaSalle Street Suite Chicago,400IL 60604

T. +1 714 427 0277

Charlotte

Raleigh 555 Fayetteville Street Suite Raleigh,300NC 27601

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Austin

T. +1 800 328 0566

98 San Jacinto Boulevard 4th Austin,FloorTX 78701

520 West Sixth Street Charlotte, NC 28202

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T. +1 310 829 2249

Vancouver 270-601 West Cordova Street Vancouver, BC V6B 1G1

T. +1 202 861 1325

T. +593 4 460 9852

Chicago

T. +1 412 456 0900

Singapore 7 Temasek Boulevard #37-01A Suntec Tower One Singapore 038987 Singapore

Pittsburgh 525 William Penn Place Suite Pittsburgh,2510 PA 15219

T. +1 415 926 7900

T. +1 312 755 1200

Oakland 1903 Franklin Street Suite Oakland,909CA 94612

San Francisco 100 Montgomery Street Suite 2300 San Francisco, CA 94104

Locations | Spread across 24 global studios, we work as one.

Seattle 1809 Seventh Avenue Suite Seattle,800WA 98101

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Geographic Reach

T. +1 212 353 7200

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Shanghai Huai Hai Plaza 1045 Huai Hai Middle Road Suite Shanghai3803200031 China

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Stamford 677 Washington Boulevard Suite Stamford,101 CT 06901

T. +1 214 224 4545

Mumbai

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T. +1 704 940 0501

T. +1 203 251 7400

T. +1 401 563 9066

10 PERKINS EASTMAN BIOTECHNOLOGY LABS 185,000SIZE sf (17,187 sm) Planning,SERVICES Architecture, Interior Design UniversityCLIENT of Southern California USC Harlyne J. Norris RelevantLOSResearchCancerTowerANGELES,CALIFORNIAExperience

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The Harlyne J. Norris Research Tower (HNRT) is a ten-story biomedical research facility for the University of Southern California School of Medicine. The research laboratory is located adjacent to the USC Norris Comprehensive Cancer Center in the heart of USC’s Health Sciences Campus east of downtown Los Angeles. The building is linked to two existing research laboratories, and that linkage gives form to the massing of the facility. The primary function of the building is to provide “incubator laboratory” space, which creates opportunities for collaboration between the University and private industry in the development of new treatment therapies and modalities, while shortening the “bench to bedside” interval. The building houses a variety of wet bench research programs, dry bench research programs, shared core laboratories, administrative spaces and a conference center. The individual research laboratory modules were designed to provide maximum flexibility due to the frequent changes that occur year to year in research programs, investigative focus and grant funding.

12 PERKINS EASTMAN BIOTECHNOLOGY LABS 52,000SIZE sf (4,800 sm) Planning,SERVICES Architecture, Interior Design UniversityCLIENT of California Davis Medical Center Telemedicine & Rural-Prime Center at UC Davis SACRAMENTO, RelevantCALIFORNIAExperience

13 Perkins Eastman designed the Telemedicine Resource Center and Rural-PRIME Facility, a four-story building located in the center of the UC Davis Medical Center campus. The facility’s innovative use of telecommunications tools aid the delivery of clinical services. This increases access to health care and helps advance healthcare delivery. This is important for areas of California where physician shortages are a persistent problem. The Center is comprised of three primary program elements: the Telemedicine Learning Center (TLC), the Center for Health and Technology (CHT), and the Center for Virtual Care (CVC). These Centers are equipped with state-of-the-art research laboratories, audio visual laboratories and clinical simulation laboratories.

14 PERKINS EASTMAN BIOTECHNOLOGY LABS 675,000SIZE sf (62,709 sm) BostonCLIENTArchitectureSERVICESProperties Relevant Experience Dock 72 Office / Lab Building BROOKLYN, NEW YORK

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Dock 72 sets the tone for 21st century manufacturing in the digital age – a laboratory for the production of ideas and innovation for TAMI (technology, advertising, media and information) start ups and businesses. Dock 72 is a mixed-use building located on the shoreline of Wallabout Bay in the Brooklyn Navy Yard. The building provides labs and office space catering to the rapidly emerging technology and creative industries in Brooklyn, and is one of the largest New York City commercial buildings to be built outside of Manhattan in decades. It has a state-of-the-art labs and Class A office infrastructure with 14’ floor-to-floor heights and 8’ of vision glass with unobstructed views of Manhattan and Brooklyn while providing light and space throughout the building. Amenities totaling 35,000 sf include first floor specialty food and beverage service, a second-floor fitness center with health and wellness programming, a rooftop conference center with sun deck, and outdoor recreation facilities including a basketball court and lawn.

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Relevant Experience

Dock 72 Office / Lab Building

BROOKLYN, NEW YORK

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18 PERKINS EASTMAN BIOTECHNOLOGY LABS 120,000SIZE sf (11,148 sm) ConceptualSERVICES Design CLIENT Confidential Relevant ConfidentialExperienceLab / Office Building SACRAMENTO, CALIFORNIA

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The four-story, 120,000 gross square foot lab and office building is designed as a flexible, mission critical and productive facility. Township 9 brings together laboratories, offices, and a conference area to encourage innovation, collaboration and discovery. The building is flooded with natural light, just one of its clever design features to reduce its energy usage. Generous floor plates allow not only the equipment and mechanical systems to be fully integrated and coordinated, but also permits potential tenants to organize their labs and offices in as many configurations as possible and to optimize critical adjacencies. Large mechanical shafts, strategically distributed, likewise provide flexibility for lab/office locations.

20 PERKINS EASTMAN BIOTECHNOLOGY LABS 240,000SIZE sf (22.300 sm) Planning,SERVICES Architecture, Interior Design GrubbCLIENTProperties 150 East Rosemary St. Lab / Office Building CHAPEL HILL, NORTH RelevantCAROLINAExperience

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This flex lab/office building in the heart of downtown Chapel Hill is the culmination of the revitalization of East Rosemary Street, which includes a new municipal parking deck and the renovation of the former NCNB office building. It is designed with floor loading, column bays, and mechanical infrastructure to create highly flexible lab and office space for a wide range of tenancy. The exterior architecture will be a modern expression that is sensitively articulated in its scale and detailing within the context of a historic college town. The development includes a significant upgrade to the public realm surrounding the site, including streetscape and green space. Once completed, this development will create necessary lab and office space for both university and private research initiatives in close proximity to the University of North Carolina campus. It will establish downtown Chapel Hill as a vibrant center of research and innovation.

22 PERKINS EASTMAN BIOTECHNOLOGY LABS 150 East Rosemary St. Lab / Office Building CHAPEL HILL, NORTH RelevantCAROLINAExperience

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24 PERKINS EASTMAN BIOTECHNOLOGY LABS The Wheeler: Biotech Incubator Building BROOKLYN, NEW YORK SIZE 980,000 sf (91,044 sm) SERVICES Planning, Architecture CLIENT Confidential Relevant Experience

This restoration and overbuild project In the heart of Downtown Brooklyn brings a new creative office work and bioscience research environment to the center of a revitalized mixed-use downtown. Consisting of three existing buildings build over the past 140+ years, the scope includes the demolition of approximately 180,000 gsf leaving roughly 680,000 gsf of existing building to remain. Another 270,000 gsf of new floor area is to be constructed in either new ground-up construction or overbuild on the existing structures. Macy’s will consolidate their uses in the existing building within the first-fourth floors as well as the three levels below grade. The developer’s laboratory / office tenants will occupy an estimated 512,000 gsf with the majority on fifth-fourteenth floors. This will be divided as roughly 300,000 gsf in renovated space and 200,000 gsf in the new portions of the building. Green roofs put “science on display” and are accessible for researchers to utilize the attention-restoring capacity of nature.

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26 PERKINS EASTMAN BIOTECHNOLOGY LABS 650,000SIZE sf (60,387sm) DynamicCLIENTUrbanArchitecture,MasterSERVICESPlanning,DesignStar,LLC The Life Science Building RelevantTHEFordhamatLandingBRONX,NEWYORKExperience

The Life Science Center at Fordham Landing represents New York City’s opportunity to become the preeminent location for regenerative medicine, advanced therapy and other similar life science companies. The17-story, 650,000 sf Life Science Center will include research labs, offices, basic science (traditional) labs, Cell and Gene Manufacturing Facility (cGMP) and conference space with attendant retail. Unique to the Life Science Center is the 85,100 square foot state of the art conference center designed to host and broadcast important scientific, biotechnology and related society events.

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Life Science Building Section

The Life Science Center is an important component of this urban renewal project. Perkins Eastman is providing full master planning services for Fordham Landing, the “Gateway to the Bronx” to create an accessible and attractive place for the people who live and work there.

28 PERKINS EASTMAN BIOTECHNOLOGY LABS The Life Science Building RelevantTHEFordhamatLandingBRONX,NEWYORKExperience

Typical Floor Plan

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30 PERKINS EASTMAN BIOTECHNOLOGY LABS 157,000SIZE sf (14,586 sm) LabSERVICESPlanning and Concept Design DuneCLIENTReal Estate Partners LP Park BioscienceSixty & Research Building NEW YORK, NEW RelevantYORK Experience

The Park Sixty is a conversion of a 15-story modern office building (1962) into a 157,000 sf medical and research facility with a retail / commercial space on the first two floors. The organization of each floor is based upon a functional laboratory module. Typical concept floor plans organizing lab, lab support, administration, and building support were developed based upon the lab planning principles. The open, contiguous lab plan provides for the flow of staff and specimens throughout the lab without having to move outside the protected environment of the laboratory space. Lab support is contiguous with the lab area it serves, minimizing redundant circulation and maximizing usable bench space. In addition to the functional advantages provided by this planning approach, the open lab will foster collaboration and communication among section personnel that might otherwise be “siloed” in a more sub-divided layout. The typical plan is developed to maximize transparency between lab & computational areas and to provide natural daylight in the maximum amount of floor area.

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Bioscience & Research Building Section

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Bioscience & Research Building Section

Relevant Experience

NEW YORK, NEW YORK

Park BioscienceSixty & Research Building

Typical Floor Plan

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Concept Plan

34 PERKINS EASTMAN BIOTECHNOLOGY LABS 7SIZEacres (3 hectares) SchoolNewCLIENTUrbanMasterSERVICESPlanning,DesignYorkUniversityofMedicine

NEW YORK, NEW RelevantYORK Experience

Alexandria Center for Life Sciences at East River Science Park

Biotechnology has emerged as one of the key industries of the new century. Despite New York City’s plethora of world-class medical talent, the industry has been constrained by the city’s limited space for commercial research. Perkins Eastman provided a design for the East River Science Park that made a significant contribution toward ensuring New York City’s role in the future of biomedical research. Located between Bellevue Hospital and NYU School of Medicine, the new 6.7-acre campus accommodates 1.5 million sf (139,356 sm) of state-of-the art research laboratories. The plan is focused on a new campus commons that provides addresses for three new lab buildings and follows the East Side’s tradition of great open spaces. It also creates strong pedestrian links with the surrounding neighborhood, and between Bellevue and NYU’s Tisch Hospital, to establish the new development as the true heart of the East Side’s biomedical corridor.

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36 PERKINS EASTMAN BIOTECHNOLOGY LABS 870,000SIZE sf (80, 825 sm) UrbanArchitecture,SERVICESDesign CLIENT Alexandria Real Estate Equities Alexandria Center for Life Sciences at East River Science Park NEW YORK, NEW RelevantYORK Experience

Steven Gifford acted as Principal in Charge for this project prior to joining Perkins Eastman. The Alexandria Center for Science & Technology at East River Science Park is an 870,000-square-foot center for commercial bioscience on Manhattan’s East Side. The Center aims to boost New York City’s biotech industry and create a thriving intellectual and social space with spectacular views of the East River waterfront. The design reflects the idea that some of the most successful working environments are characterized by collaboration, the active exchange of ideas and respect for their surroundings. The interconnectivity of public and private is a key component of this striking design. A variety of spaces, some busy and active, others ideal for quiet introspection are all designed to encourage scientific breakthroughs. The Winter Garden—a crystalline pavilion connecting the two primary biotech facilities—acts as the conduit between the East River Science Park and Bellevue Hospital and functions as a display space.

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24SIZEacres of land and 50 acres of riparian rights; 3.2 million sf of new residential, hotel, lab/ office, restaurant, retail and cultural space

WaterfrontHoffman-MadisonCLIENTDesign,Architecture,MasterSERVICESPlanning,UrbanInteriorDesignLLC

The BROOKLYN,DevelopmentCommercialWharfNEWYORK

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Relevant Experience

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The design for The Wharf restores the connections between the city and its waterfront by integrating land and water functions, creating an enduring place that turns into a highly sought-after destination for residents and tourists throughout the Washington Metropolitan Area. In order to create a lively urban destination, Perkins Eastman emphasized placemaking in the design of the site’s master plan. A variety of outdoor spaces create attractive places that provide the community and its visitors an enjoyable and enriching experience. The design of the site’s structures focuses on the pedestrian’s perspective, creating a family of buildings along the Wharf, each with its own identity, resulting in a captivating street-level environment.

40 PERKINS EASTMAN BIOTECHNOLOGY LABS 240,000SIZE sf (22,298 sm) Architecture,SERVICES Urban Design, Interior Design WaterfrontHoffman-MadisonCLIENTLLC 800 Maine Avenue Office/Lab Building at The Wharf WASHINGTON, RelevantDC Experience

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800 Maine Avenue is a 240,000sf, 11-story office building, located on a parcel being half the depth from Maine Avenue to the water. The Class A commercial mixed-use building features a compact core, retail on the ground level, a large third floor balcony, and penthouse level amenity space. The penthouse level includes a 2,000sf event space, kitchen and storage support spaces, and an adjacent pre-function area.

42 PERKINS EASTMAN BIOTECHNOLOGY LABS 730,000SIZE sf (67,819 sm) Planning,SERVICES Architecture, Interior Design MemorialCLIENT Sloan-Kettering Cancer Center Rapid Response Lab at the MSK David Koch Center for Cancer Care NEW YORK, NEW RelevantYORK Experience

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The new Memorial Sloan-Kettering David Koch Center for Cancer Care features a “Rapid Response Laboratory” which serves as a “STAT” lab for quick turn-around clinical testing, as well as the staging and shipping of patient specimens for routine testing at the main hospital campus. The facility includes a Blood Bank Depot & Cell Product Depot for the receipt, staging and internal distribution of blood & cell product for patient infusion. Planned as an open contiguous laboratory using a standardized lab bench module for both open lab & support areas, the design minimizes extraneous circulation and yields optimal usable testing bench and equipment space. With the use of a flexible, mobile casework system and overhead “plug & play” utilities connections, this design affords enormous flexibility and adaptability to changes in equipment and allows for easy reconfiguration of the space in response to the changing needs of Laboratory Medicine. The project includes Dermatopatholgy, Hematopathology & Cytopathology Laboratories for receipt of specimens, processing & microscopic evaluation of skin biopsies, blood smears & bone marrow aspiration biopsies, and fine needle aspiration biopsies.

LITTLE ROCK,

RelevantARKANSAS Experience

Donald for at University of

Geriatric Research

W. Reynolds Institute

Arkansas

44 PERKINS EASTMAN BIOTECHNOLOGY LABS 154,000SIZE sf (14,307 sm) Planning,SERVICES Architecture, Interior Design UniversityCLIENT of Arkansas

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Intended to accelerate and disseminate patient-oriented research, the Institute pioneers integrated therapeutics in the care of the aging. Researchers and staff provide educational programs on aging for healthcare professionals and the public, and coordinate nationally with officials in an effort to influence public policy on aging issues. The Institute houses a primary care and physical rehabilitation clinic; four floors of clinical and basic science research laboratories (including a satellite animal facility); office and administrative areas, library, as well as classrooms and a lecture hall equipped for video conferencing and distance learning. Controlled natural daylighting enhances the building environment—improving productivity, comfort, and energy efficiency

46 PERKINS EASTMAN BIOTECHNOLOGY LABS 34,000SIZE sf (3,158 sm) StonybrookCLIENTArchitectureProgramming,SERVICESUniversity Simons Center for Geometry & Physics at RelevantSTONYBROOK,UniversityStonybrookNEWYORKExperience

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The Simons Center is a world-class sustainable mathematics research and physical sciences facility representing the convergence of cutting-edge ideas between geometry and physics. Its main goals are to create a dynamic environment for interaction, academic study, and collaboration between the two schools of thought. Unlike adjacent buildings, the new Center is used primarily for faculty members, post-doctoral, and graduate students and focuses on faculty offices and discussion spaces more than instructional space. The design took cues from prominent research institutions and innovative companies that share similar functions in interdisciplinary thinking, collaboration, and research. Programmatic elements include a 250-person lecture hall/auditorium, office space, seminar rooms, a multi-story atrium, a wide-variety of small group study spaces, and open discussion areas. As the nexus for the school’s programs, the building itself is a prominent, technologically sophisticated gateway on the campus that employs sustainable strategies that achieve LEED Gold certification.

48 PERKINS EASTMAN BIOTECHNOLOGY LABS 68,300SIZE sf (6,345 sm) Programming,SERVICES Planning, Architecture, Interior UniversityCLIENTDesign of Chicago University of Chicago Albert Michelson Center for Physics CHICAGO, RelevantILLINOIS Experience

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The renovation and addition of the Michelson Center for Physics provides theoretical and experimental physicists a collaborative, future-forward facility on the University of Chicago campus. Originally completed in 1964, the rigorously symmetrical structure could not accommodate the programmatic needs of the University’s multidisciplinary physics research. In response, Perkins Eastman completed a two-story expansion, comprehensive gut renovation, and a complete new enclosure to transform the monolithic building into an inviting new institute.

To achieve the balance of individual focus and group work necessary to the learning process, Perkins Eastman incorporated a variety of collaboration areas as well as flexible experimental labs and workspaces within the building. The design encourages connectivity and strengthens intellectual discourse between the two branches of physicists, who are co-located at the university for the first time in decades.

50 PERKINS EASTMAN BIOTECHNOLOGY LABS 95,000SIZE sf (8,825 sm) Programming,SERVICES Architecture, Interior Design NYUCLIENTLangone Health (formerly Winthrop University) NYU HealthLangoneResearch & Academic Center LONG ISLAND, NEW RelevantYORK Experience

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This new translational research and academic facility fosters state-of-the art research in the treatment and prevention of pediatric and adult diabetes in collaboration with patient care and community education. To encourage this interaction, open, flexible laboratories connect to the clinical research and patient care environments through communal spaces. In addition, a large open circulation stair, populated with small conversation zones, encourages interaction between the ground-floor education and community outreach functions and the upper floors, visibly promoting the interactive and health-oriented mission of the translational environment. Specific program features include classrooms; a 350-seat amphitheater for school and community lectures; and an entire floor for future bench research, providing wet laboratory space, animal research, laboratory support functions, and administrative area.

NYU HealthLangoneResearch & Academic Center

LONG ISLAND, RelevantYORK

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Experience

NEW

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54 PERKINS EASTMAN BIOTECHNOLOGY LABS Stockton University New STOCKTONScienceGatewayComplexUNIVERSITY|GALLOWAY,NJ 55,746SIZE sf (5,179 sm) Planning,SERVICES Architecture, Interior Design StocktonCLIENT University Relevant Experience

The new 108,000 sf, three-story Unified Science Center and Health Sciences Center houses state of-the-art teaching and research labs for various disciplines in the sciences—for example, applied physics, biochemistry/ molecular biology, marine science, sustainability, organic chemistry, anatomy and physiology.

The new facilities will provide Stockton students research opportunities that far exceeds any other experience they may receive at another university. The research collaboration that Stockton students receive prepares them for graduate school or their field of study. The Physics research facility holds a new Atomic Force Microscope (AFM). The AFM provides research students and cross-curriculum faculty the ability to create images of atoms and map the surface structure of materials. The greenhouse contains three temperature zones and four sections: tropical, desert, main collection and research/class.

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56 PERKINS EASTMAN BIOTECHNOLOGY LABS Rutgers University New Science & Nursing Building RUTGERS UNIVERSITY | CAMDEN, NJ SIZE 101,000 sf (9,383 sm) SERVICES Lab Planning, Architecture CLIENT Rutgers University Relevant Experience

Perkins Eastman’s design bridges academic programs with the clinical experience and expands Rutgers’ ability to prepare for a new generation of science and nursing leaders. The primary interior circulation parallels the city grid and is repeated on all four levels of the building. Along the southwest façade this “student street” provides access to major learning spaces, opportunities for collaboration and socializing, and views overlooking a park. The biology and physics laboratories provide both research and teaching spaces. Places for quiet individual study drive the design and create environments for small groups to collaborate on assignments and for large gatherings to celebrate accomplishments and share information. A combination of open stairs and two-story volumes reinforce the visual and physical connections within the building. The design reveals the vitality and content of the academic programs and promotes community among the users. The building was designed to LEED Silver standards.

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58 PERKINS EASTMAN BIOTECHNOLOGY LABS TherapeuticsVolastra at the Mink Building NEW YORK, NEW YORK SIZE 150,000 sf (13,935 sm) / 10,000 sf for Volastra Therapeutics SERVICES Planning, Architecture,Programming,InteriorDesign CLIENT Janus Property Development Relevant Experience

59 Perkins Eastman is designing and outfitting the new headquarters of Volastra Therapeutics, a New York City based biotechnology company dedicated to developing therapies that focus on endoplasmic reticulum (ER) stress pathways in multiple diseases, such as cancer. The 10,000 square feet state-of-the-art space will contain dedicated wet labs, dry labs, and conference rooms, collaborative research spaces with minimal distraction or “huddle rooms” and administrative spaces. A central “write-up” room is accessible by researchers and scientists for analyzing data, writing up experimental reports, summaries and preparing for presentations. With open views and sunlight, the location allows for data and progress in drug discovery research and development to be communicated frequently to teams and departments to function effectively. The new headquarters of Volastra in the Mink Building is designed for growth, flexibility and transparency with the capacity to accommodate over 50 employees over a 5-year period.

60 PERKINS EASTMAN BIOTECHNOLOGY LABS 322,000SIZE sf (29,914 sm) Planning,SERVICES Architecture, Interior Design DormitoryCLIENT Authority of the State of New York NYC Office of the Chief BiologyExaminer:MedicalDNAForensics Lab NEW YORK, NEW RelevantYORK Experience

The Office of the Chief Medical Examiner in New York City performs more DNA analyses than any other public laboratory in the country. Anticipating the full use of DNA testing not only in solving crimes but for supporting law enforcement in general, the Medical Examiner determined that a new standalone DNA Forensic Biology Laboratory was necessary. The state-of-the-art DNA facility houses numerous forensic laboratories of various complexities, such as: a casework analysis lab to identify perpetrators; an exemplar lab to process both people known to be at the crime scene and paternity samples; a high-sensitivity lab for property crimes; an in-situ lab for ascertaining if genetic defects causing death have been transmitted within a family, and a mitochondrial lab for body identification and missing persons cases. The facility also houses a scanning electron microscope, biochemistry and immunohistochemistry labs, quality control/quality assurance labs, training labs, and research and development labs, in addition to support space comprising office, archive storage, evidence holding areas, conference center, and subterranean parking.

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62 PERKINS EASTMAN BIOTECHNOLOGY LABS Kolb NEWCenterUniversityLabsResearchatColumbiaMedicalYORK,NEWYORK SIZE 33,000 sf (3,066 sm) SERVICES Planning, Architecture Interior Design CLIENT NYS Office of General Services Relevant Experience

The scope of the project covers several floors of small, outdated and enclosed laboratories for a combined 33,000 sf multi-level rehabilitation and conversion of core laboratory, research facilities as well as teaching and administrative facilities. An existing floor space of approximately 10,969 gsf was converted to a wet lab, accommodating simultaneous and separate ventilation and utility connections at individual lab modules to ensure the reliability and accuracy of results as well as occupant safety throughout the space. The 4th floor rehabilitation at 11,000 sf includes an open research wet lab dedicated to performing neuroscience research; faculty and administrative offices, staff work areas, and support spaces. Laboratory spaces comprise animal testing, two photon microscopy, tissue culture, equipment and storage support rooms, a break room, and an accessible toilet with shower. Finally, the 8th floor (11,000 sf) rehabilitation houses a new independent vivarium with equipment and appropriate support space.

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64 PERKINS EASTMAN BIOTECHNOLOGY LABS Relevant NEWUniversityat&TransfusionExperienceMedicineCellTherapyUnitNYPH-ColumbiaYORK,NEWYORK SIZE 4,350 sf (404 sm) SERVICES Planning, Architecture Interior Design CLIENT New York Presbyterian Hospital (NYPH)

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This mission-critical project required an update to the Transfusion Medicine Department, a new Apheresis center, new Cell Therapy laboratory space designed to current Good Manufacturing Practice (cGMP) Standards, Blood Bank renovations, and office and support spaces. The efficiently organized 1,250 sf Apheresis center consists of 4 patient bays, including one with a door for added privacy, a blood draw station, physician and nursing work areas, soiled utility, clean supply rooms, one office, reception, and patient waiting area. Thoughtfully considered finishes provide for patient comfort and staff conveniences. The cGMP laboratory will consist of a standard Bio Safety Level 2 (BSL2) central support lab between two cGMP classified and Isolation class 7 cell therapy laboratories. Within the area of renovation, the adjacent blood bank will be mildly updated and increased by 150 square feet to incorporate new equipment, and new support functions for the GMP laboratory will include office space, maintenance / storage, and CO2 tank closet.

66 PERKINS EASTMAN BIOTECHNOLOGY LABS 47,000SIZE sf (4,366 Programming,SERVICESsm) Planning, InteriorArchitecture,Design CLIENT Smith & Nephew Smith+Nephew: Robotics R+D RelevantPITTSBURGH,HeadquartersPENNSYLVANIAExperience

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Smith+Nephew, relocated to the heart of “Robotics Row,” an innovation epicenter for robotics, technology, and artificial intelligence within the historic Strip District neighborhood. The new headquarters supports groundbreaking research and development of robotic surgical systems, and provides areas to facilitate enhanced training of healthcare professionals now and into the future. The project encompasses three floors connected by a distinctive wood and glass staircase to encourage team circulation and collaboration. Additional spaces include reception area, secure high-bay makerspace, cadaver and prototyping labs, collaboration zones, enclosed offices, small nooks, and lounges. Industrial-grade garage doors on the ground floor open to an exterior courtyard, providing valuable connection to the community, and encouraging an active, healthy work environment.

68 PERKINS EASTMAN BIOTECHNOLOGY LABS 11,500SIZE sf (1,068 TechnologiesPhilipsCLIENTInteriorPlanning,SERVICESsm)Programming,Architecture,DesignHealthcareLtd. Philips Respironics New InnovationDigitalHub PITTSBURGH,RelevantPENNSYLVANIA Experience

69 Philips Respironics, a global leader in the development of innovative sleep and respiratory solutions, required a new space that i based on the principles of shared space, flexibility, mobility, and sustainability. The new dynamic Digital Hub workplace serves as the new prototype for its operations. It provides a creative environment for new product development, product research, marketing, and cocreation with outside companies and the local institutional community. The space promotes connectivity and collaboration by providing free-address, desk sharing, and alternative work settings—crucial requirements to attract and retain top employees. A cue from Philips’ expertise in the respiratory market is reflected in the ceiling and partitions, which is designed to appear as though it is “breathing”—a metaphor for the type of important product development occurring in the new workplace.

70 PERKINS EASTMAN BIOTECHNOLOGY LABS 4,200,000SIZE sf land area (390,192 sm) ConceptualPlanning,SERVICES Design ResearchCLIENT FoundationTriangle Research Triangle Park Center RESEARCH TRIANGLE PARK, NORTH CAROLINA Relevant Experience

The Research Triangle Park Center (Park Center) is a bold new vision that repositions the Research Triangle Park (RTP) as the “campus and workplace of the future.” This urban center for the RTP is an exciting new live-learn-work-research-shop-play environment that is more sustainable and attractive to a new generation of workforce. It combines residential and retail space with an office workplace in a compact and walkable setting. Nature has always been a significant part of the landscape dominated, quiet, clean, suburban office park environment at RTP, but now it is no longer just a backdrop. At Park Center, nature and landscape become a central theme. A new urban park at the center of the proposed new development becomes the gateway to a regional park system that runs through all 7,000 acres of RTP, connecting all the RTP companies via trails and bikeways. While being sustainable, market-driven, and implementable, it is the focus on a shared public realm that makes Park Center an attractive new destination at RTP that supports growth and collaboration amongst all the institutes and companies of RTP.

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72 PERKINS EASTMAN BIOTECHNOLOGY LABS 107SIZE acres (43 hectares) SanUniversityCLIENTStakeholderDesignRealmSiteProgramming,SiteMasterSERVICESplanning,planning,Analysis,PublicDesignGuidelinesoutreachofCaliforniaFrancisco UCSF Comprehensive Parnassus Heights Plan SAN FRANCISCO, RelevantCALIFORNIAExperience

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The master plan will help to “future-proof” the campus and enable its mission as a top tier research, clinical, and educational institution while enhancing the public realm and connections at the ground plane, improving public access to the campus. Perkins Eastman will create new spaces for collaboration across multiple disciplines and plan and accommodate growth in clinical, research, educational, administrative and support spaces, as well as new campus amenities and housing. The plan will present and facilitate ongoing discussions and synthesize feedback from faculty, administration, the public, and staff while also incorporating considerable sustainability goals.

Belward Research Campus at Johns Hopkins University

COUNTY, MARYLAND Relevant Experience

MONTGOMERY

74 PERKINS EASTMAN BIOTECHNOLOGY LABS 108SIZE acres (43.7 hectares) JohnsUrbanMasterSERVICESPlanning,DesignCLIENTHopkinsRealEstate

75 Perkins Eastman developed a concept plan for the future of the Johns Hopkins Belward Research Campus and surrounding greater Shady Grove Life Science Center as part of the Vision 2030 for the Shady Grove Sector. The planning and urban design process resulted in a conceptual plan that offers a new vision for the development of state-of-the-art applied research in a thriving, mixed-use community. The new vision for the community addresses land use; transit-oriented development opportunities; parks and open spaces; traffic and transportation; and issues of livability and mixed use development. The success of this campus depends not only on the creation of new research facilities, but also on a commitment to smart growth and sustainability and on the creation of a new “place” within Montgomery County. The Montgomery County Council approved the plan. The First Phase includes 500,000 gsf facilities for the National Cancer Institute.

76 PERKINS EASTMAN BIOTECHNOLOGY LABS 12,000,000SIZE sf (1,114,836 sm) CenterDestinationCLIENTMasterSERVICESPlanningMedicalEDA Mayo RelevantROCHESTER,MedicalDestinationClinicCenterMINNESOTAExperience

At the heart of DMC is Discovery Square, key milestone and the first-of-its kind urban bioresearch campus bringing together scientists, researchers, clinicians, medical professionals and entrepreneurs in a state-of-the-art collaborative environment.

77

Destination Medical Center (DMC) is a long-term economic development initiative designed to position Minnesota as a global center for excellent medical care and a scalable engine for employment and business in Rochester. It is the largest in the largest public-private partnership in Minnesota. Perkins Eastman devised an ambitious and achievable master plan for the Mayo Clinic Destination Medical Center (DMC) that transforms the downtown skyline and streetscape, and makes Rochester a true destination city. By creating a 20-year multi-phase plan that is market driven and flexible, the design has positioned DMC to incrementally embrace and leverage the evolving characteristics, demographics, and development opportunities that its hometown has to offer.

78 PERKINS EASTMAN BIOTECHNOLOGY LABS

Science & Technology Team

Previous Work 1 2 4 5

79 1. Genzyme Life Science Research Facility Beijing, China 2. Dow Corning / Rohm & Haas R&D Center Shanghai, China 3. Columbia University Audubon Biotechnology Center New York, New York 4. Duke University French Family Science Center Durham, North Carolina 5. National University of Singapore Yong Loo Lin School of Medicine Singapore 6. Duke University / National University of Singapore Graduate Medical School Singapore Notable projects of Steven Gifford and members of the Science & Technology Practice Area prior to joining Perkins Eastman. 63

80 PERKINS EASTMAN BIOTECHNOLOGY LABS 1 2 4 5

Previous Work

Science & Technology Team

81 1. Novartis Research & Development Center East Hanover, New Jersey 2. L’Oreal R&D Facility Clark, New Jersey 3. Pfizer B500 Campus Gateway Sandwich, UK 4. Glaxo Smith Kline Discovery Research Automation Upper Providence, Pennsylvania 5. Boehringer Ingelheim: Cytotoxic & Non Cytotoxic Development Facility Roxane, Ohio 6. Eli Lilly Surrey, UK Notable projects of Steven Gifford and members of the Science & Technology Practice Area prior to joining Perkins Eastman. 63

www.perkinseastman.com STEVENCONTACTGIFFORD AIA, NCARB Principal | Practice Area Leader Science and s.gifford@perkinseastman.comTechnology SHEFALI RAICHAUDHURI AIA, LEED AP Associate s.raichaudhuri@perkinseastman.comPrincipal

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