Best tropoflavin powder | 7,8-DHF manufacturer Wholesale

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7,8-dihydroxyflavone (38183-03-8) Specifications Product Name

7,8-dihydroxyflavone

Chemical Name

Tropoflavin; 7,8-dihydroxy-2-phenylchromen-4-one ;

Synonyms

7,8-dihydroxy-2-phenyl-4H-chromen-4-one; 7,8-dihydroxyflavone hydrate 7,8-DHF; 4H-1-Benzopyran-4-one; 7,8-Dihydroxy-flavone; 7,8-Dihydroxy-2-phenyl-chromen-4-one; 7,8-Dihydroxy-2-phenyl-4-benzopyrone;

CAS Number

38183-03-8

InChIKey

COCYGNDCWFKTMF-UHFFFAOYSA-N

Molecular Formula

C15H10O4

Molecular Weight

254.24

Monoisotopic Mass

254.05790880

Melting point

243-246°C

Boiling point

494.4±45.0 °C(Predicted)

Color

Yellow powder

Form

Solid

Solubility

DMSO: soluble24mg/mL

Storage Temperature

Inert atmosphere,Room Temperature

Application

7,8-dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

Testing Document

Available

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The research about plants, animals, and chemicals is still now ongoing to cure disease and improve human health. Examples of chemicals that are now under thorough research are the tropoflavin powder that contains chemical tropoflavin, a plant-derived molecule that is said to be a solution for curing different diseases or brain illnesses.

Tropoflavin,the chemical name for 7,8-dihydroxyflavone, also known as 7,8-DHF. 7,8-DHF was found to be an effective mimic of BDNF and can act on TrkB in a similar way. This means that 7,8-DHF can theoretically produce similar effects to BDNF in the brain, and is theoretically more useful for treatment due to its better absorption and ability to cross the blood-brain barrier.

There some proper noun is hard to understand, to better understand this article, you can check more information in the FAQs.

7,8-dihydroxyflavone powder - What is 7,8-dhf?

7,8-dihydroxyflavone powder, or 7,8-DHF, which is a naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia. In animal models, 7,8-DHF has shown efficacy against several diseases of the nervous system, including Alzheimer's, 2

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Parkinson's, and Huntington's. It has a role as a plant metabolite, a tropomyosin-related kinase B receptor agonist, an antidepressant, an antioxidant and an antineoplastic agent.

As a mimic of the agonist of tropomyosin receptor kinase B (TrkB) affecting brain-derived neurotrophic factor (BDNF), after 7,8-dihydroxyflavone binds to the TrkB receptor, the signaling cascade is initiated, Can promote neuron survival and regeneration.

7,8-DHF also has a protective effect on cell apoptosis. It can cross the blood-brain barrier and directly act on the brain TrkB receptors; this cannot be achieved by peripheral injection of BDNF. Therefore, it is a very promising natural compound with cognitive functions.

In addition, 7, 8-DHF has oral biological activity, and exerts its neurotrophic activity in the central nervous system by penetrating the brain blood barrier (BBB).

7,8-dihydroxyflavone supplements are also known by a few different names, including:

38183-03-8 7, 8 - Dihydroxyflavone 3

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7,8-dihydroxy-2-phenyl-4H-chromen-4-one Tropoflavin 7, 8-Dihydroxyflavone hydrate 7,8- Dihydroxy-flavone 7, 8 - DHF 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl7,8-diOH-Flavone

7,8-dihydroxyflavone (7,8-dhf) Mechanism Of Action 7,8-DHF mimics the effects of brain-derived neurotrophic factor (BDNF) in brain cells by activating tropomyosin-related kinase B (TrkB) receptors, the typical target of BDNF.

The therapeutic potential of BDNF is restricted due to its short half-life (less than 10 minutes) and its inability to cross the blood-brain barrier because of its large size.

Unlike BDNF 7,8-DHF is able to penetrate the blood-brain barrier and enter the central nervous system (CNS).

7,8-DHF also increases the production of Nrf2. Nrf2 increases antioxidants enzymes such as heme oxygenase 1 (HO-1) and also enzymes that repair DNA (8-oxoguanine DNA glycosylase-1 – OGG1).

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Why do people use 7,8-Dihydroxyflavone?

People who self-experiment with 7,8-Dihydroxyflavone powder often state they use it to improve their:

 Memory  Mood  Energy  Learning

There is a lack of scientific evidence for the effectiveness of 7,8-DHF for any of these purposes, especially in healthy humans

7,8-dihydroxyflavone benefits - What does 7,8-dihydroxyflavone do?

Let's move on to why you started researching 7,8-dihydroxyflavone powder in the first place - the benefits.

Studies in animals show that 7,8-dihydroxyflavone benefits with brain repair, long-term memory, depression, and neurodegenerative diseases. However, studies in humans have not yet begun.

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Here are the 7,8-dihydroxyflavone benefits:

It imitates BNDF (Brain-derived neurotic factor)- BNDF is responsible for replenishing brain cells and maintaining good functioning of the brain nerves.

Protects brain cells- Tropoflavin is believed to be a good solution to make healthy brain cells that will improve memory and make you smarter.

Memory support – It provides memory support by blocking harmful chemicals in the brain, it makes the brain stronger.

Balanced mood- chemicals that affect hormones secreted in the brain that have something to do with the way we feel, commonly known as mood. It improves mood and keeps the mind positive.

Preserve brain function – the more we use our brain, the more it became stronger.

The use of Tropoflavin powder keeps our mental capacity intact and makes our minds healthy and functioning well.

Safe- According to researchers, 7,8-dihydroxyflavone is safe and they say it has mild side effects that are just not threatening to humans.

Alzheimer’s Disease - 7,8-dihydroxyflavone powder is believed to be a solution for this disease since it reduces stress in the brain, prevents cognitive dysfunction and memory deficit, it also prevents synapses from being ruptured, and reduced amyloid plaque formation.

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How to take 7,8-dihydroxyflavone supplement?| How much tropoflavin powder should I take 7,8-dihydroxyflavone Dosage 7,8-dihydroxyflavone supplement can be purchased as capsules/pills, or powder. For 7,8-dihydroxyflavone powder form, if you want to get the best 7,8-dihydroxyflavone powder, we advise you source the supplier from China.

There are some user experiences on Reddit and Amazon store regarding the effects of 7,8-dihydroxyflavone. Take a look at some of the 7,8-dihydroxyflavone reviews, you will find that the most common dosage in commercially available supplements is 25mg per day. Every 25mg of this supplement 1-2 times a day will surely make for better brain health. It appears to be subject to extensive first-pass metabolism in the liver. Due to improved bioavailability, sublingual administration (under the tongue) may be preferred.

7,8-dihydroxyflavone side effects Even currently there are no human studies on 7,8 - DHF, many supplement companies added 7,8 dihydroxyflavone to their productline. They buy 7,8 dihydroxyflavone powder wholesale from Chinese manufacturer to produce dietary supplements. Users have anecdotally reported it may cause mild and rare side effects such as dizziness, 7

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insomnia and nausea.

7,8-dihydroxyflavone risks You should always consider the risks of a nootropic before you use it

7,8-dihydroxyflavone food sources - How to supplement 7,8-dihydroxyflavone naturally?

7,8-dihydroxyflavone is a member of a family of antioxidant compounds naturally found in foods ranging from cherries to soybeans. Researchers have identified a compound that mimics one of the brain's own growth factors and can protect brain cells against damage in several animal models of neurological disease

Why buy tropoflavin for better brain health When compared closely to BDNF, 7,8-dihydroxyflavone (7,8-dhf) actually performs much better. It is shown to penetrate the blood-brain barrier easier and demonstrates higher oral bioavailability.

7,8-dihydroxyflavone powder and similar

synthetic derivatives are undergoing continued research for their potential cognitive benefits.

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Best tropoflavin powder manufacturer | Where to buy 7,8-dihydroxyflavone powder bulk?

In the modern world, you can buy 7,8-dihydroxyflavone powder at the comfort of your home online. However, you will have to check widely for high quality 7,8-dihydroxyflavone powder suppliers.

Customer reviews are one way to guarantee the 7,8-dihydroxyflavone benefits and also gather information on possible side effects. Alternatively, you can source ,8-dihydroxyflavone powder from suppliers authorized to sell these supplements.

Phcoker offers bulk or wholesale of 7,8-DHF Powder. Phcoker’s 7,8 Dihydroxyflavone powder has been lab-tested and verified for both product purity and identity.

Consider buying 7,8-dihydroxyflavone powder wholesale quantities to enjoy the discounts there-in.

FAQs What are BDNF levels?

In healthy volunteers, mean plasma BDNF level was found to be ∼ 92.5 pg/ml (8.0–927.0 pg/ml). It was higher in women, and decreased with advancing age in 9

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both genders [54]. BDNF is widely distributed in various regions of the brain, and aids in survival, support and function of neurons.

What increases BDNF the most?

Exercise is the fastest and most effective way to boost BDNF levels, and improve learning, memory and mood. In just 5 weeks, mild-intensity exercise significantly increased BDNF levels and reversed cognitive decline in old rats What increases BDNF in the brain?

BDNF is considered the most susceptible to regulation by exercise of any of the neurotrophic factors. Physical exercise has been consistently shown to increase levels of BDNF mRNA and protein expression in the hypothalamus, striatum and other cortical areas.

What is BDNF and why is it important?

The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.

How can I raise my BDNF? Control Stress and Inflammation Levels. ...

Exercise Regularly. ...

Prioritize Your Social Connections. ...

Breath Fresh Air and Get Naked in the Sun. ...

Drink Coffee and Take Coffee Berry Supplements. ...

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Consume a High-Protein Diet. ...

Restrict Carbohydrate Intake (Sometimes) ...

Fast Correctly.

What stimulates BDNF release?

Neuropeptides known to be present in enteric neurons innervating the longitudinal layer increase the expression of BDNF mRNA and protein in smooth muscle cells and stimulate the release of BDNF. What drugs increase BDNF? Antidepressant drugs, e.g. SSRIs, increase BDNF in the hippocampus and PFC. Ketamine rapidly increases BDNF protein levels in the hippocampus. Ketamine elicits hippocampal potentiation dependent on BDNF expression. BDNF is required for the antidepressant effects of traditional antidepressant drugs and ketamine.

Does exercise increase BDNF in humans?

It was recently demonstrated that physical exercise can increase plasma and/or serum BDNF concentration in humans. It was also reported that physical exercise or electrical stimulation can increase the BDNF expression in the skeletal muscles.

What is the role of BDNF in the brain?

The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells.

What does TrkB stand for?

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Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).

Where are TrkB receptors found?

TrkB is expressed in both the central (CNS) and peripheral nervous systems (PNS). In the CNS, a high TrkB expression is observed in cerebral cortex, hippocampus, thalamus, choroid plexus, and granular layer of the cerebellum, brain stem, retina and the spinal cord What is p75 neurotrophin receptor? p75 neurotrophin receptor (p75NTR), also known as CD271, is the low-affinity receptor that, together with the tyrosine kinase receptor tropomyosin-receptor kinase (Trk), mediate neurotrophin (NT) functions.

Reference: [1] Johnson RA, Lam M, Punzo AM, Li H, Lin BR, Ye K, Mitchell GS, Chang Q (2012).

"7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome". J. Application Fizol . 112(5): 704–10. doi: 10.1152/japplphysicol.01361.2011 . PMC 3643819 . PMID 22194327 .

[2] Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q (2012). "7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats". J. Neurochem. 122 12

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(4): 800–11. doi: 10.1111/j.1471-4159.2012.07830.x . PMID 22694088.

[3] Zeng Y, Wang X, Wang Q, Liu S, Hu X, McClintock SM (2013). "Small molecules activating the TrkB receptor for the treatment of various CNS disorders". CNS Neurone Disorder Drug Targets . 12 (7): 1066–77. doi: 10.2174/18715273113129990089 . PMID 23844685.

[4] Latha Devi & Masuo Ohno. 7,8-dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease. Neuropsychopharmacology volume 37, pages434–444 (2012).2011;9:7.

[5] Chaoyang Liu, Chi Bun Chan, and Keqiang Ye. 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Transl Neurodegener. 2016; 5: 2. doi: 10.1186/s40035-015-0048-7.

PMCID: PMC4702337

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