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of extracting these saponins, cycloastragenol and astragaloside IV, is usually difficult due to the high level of purification required. While both cycloastragenol and astragaloside IV are derived from astragalus herb, cycloastragenol can also be obtained from astragaloside IV through hydrolysis process. These two compounds have a similar chemical structure, however, cycloastragenol is lighter in molecular weight than astragaloside IV and is also more bioavailable.
The Mechanism of Action of Cycloastragenol i. Telomerase activation Telomeres are nucleotide repeats at the ends of linear chromosomes and are bound by a certain set of proteins. Telomeres naturally shortens with every cell division. Telomerase, a ribonucleoprotein complex consisting of catalytic reverse transcriptase enzymes (TERT) and a telomerase RNA component (TERC) lengthens telomeres. Since the key role of telomeres is to protect chromosomes from fusion and degradation, cells usually recognize extremely short telomeres as damaged DNA.
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