Is Palmitoylethanolamide Really Effective In Treating Pain?

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Is Palmitoylethanolamide Really Effective In Treating Pain?

What is Palmitoylethanolamide(PEA)?

Palmitoylethanolamide powder (544-31-0) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. Palmitoylethanolamide (PEA) is produced in the body to combat pain and inflammation. Many animals and plants also produce PEA. The highest amounts can be found in soy lecithin, soybeans, egg yolk, peanuts, and alfalfa. This fatty acid can safely boost your natural cannabinoids and protect the nerves throughout your body. Its benefits are encouraging for a wide range of difficult-to-treat disorders.

Palmitoylethanolamide has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-α). However, the presence of Palmitoylethanolamide (and other structurally related N-acylethanolamines) has been known to enhance anandamide activity by a so-called “entourage effect”. Raw Palmitoylethanolamide has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties.

As a supplement, PEA is available in tablet, capsule, and powder form. In Italy and Spain, PEA is marketed as a food for special medical purposes.

Palmitoylethanolamide powder Mechanism of Action 1

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Palmitoylethanolamide activates the energy-boosting, fat-burning, and anti-inflammatory PPAR alpha. By activating this key protein, PEA stops the activity of pro-inflammatory genes and the production of many inflammatory substances.

Palmitoylethanolamide reduces the activity of the bliss gene FAAH that breaks down natural cannabinoid anandamide. This increases the levels of calming anandamide in your body, helping to combat pain and increase relaxation. It may also activate cannabinoid receptors (CB2 and CB1).

Palmitoylethanolamide contains the palmitic acid in its structure. The starting point for making PEA in the body is precisely this saturated fatty acid.

However, simply increasing your intake of palmitic acid or other dietary fats will not affect Palmitoylethanolamide production in the body. This is because your body will use PEA only when it needs to compensate for inflammation or pain, and its levels will also normally vary throughout the day. The best way to get the benefits of PEA are standardized supplements, or alternatively PEA-rich foods.

The use/application of Palmitoylethanolamide ▪ Pain management ▪ Anti-inflammatory ▪ Anti-nociceptive ▪ Neuroprotective ▪ Anticonvulsant properties.

How do we take Palmitoylethanolamide?

More clinical studies would be beneficial but there are still enough data to say that Palmitoylethanolamide is an exceptionally safe supplement. Even long-term PEA supplementation is not linked to any adverse effects.

Palmitoylethanolamide was used in doses of 300 mg to 1.8 g/day in clinical studies.

▪ At least 600 mg/day may be needed to relieve nerve pain, while doses of 1.2 g/day were used for diabetic nerve pain.

▪ PEA up to 1.8 g/day was used for reducing damage to eye nerves in people with glaucoma or diabetes.

▪ For fighting the common cold, 1.2 g/day was the standard dosage.

▪ The total dose can be split up into two during the day. We recommend starting out with the standard dosage of 1.2 g/day divided into 600 mg in the morning and 600 mg in the afternoon. Track your response and gradually increase the dosage after 1 month if needed.

Micronized Palmitoylethanolamide supplements were used in most studies are superior to other forms. Micronized Palmitoylethanolamide is a fine powder that is better absorbed and more effective. Palmitoylethanolamide

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combined with luteolin was also used in clinical trials and will be exceptionally beneficial for brain health.

Some potential benefits of Palmitoylethanolamide Since its discovery in the 1950s, researchers have been fascinated with Palmitoylethanolamide. As a strong and safe natural painkiller and anti-inflammatory, Palmitoylethanolamide offers hope for a lot of people suffering from chronic and neuropathic pain. Except this benefit, Palmitoylethanolamide powder may offer potential benefits for your personal health. There are some benefits for reference: ♦ PEA Reduces Pain and Inflammation ♦ Enhances Brain Health and Regeneration ♦ Good for Your Eyes ♦ May Protect Your Heart ♦ Reduces Gut Inflammation ♦ May Reduce Depression Symptoms. ♦ Reduces Symptoms of Multiple Sclerosis ♦ May Fight the Common Cold ♦ Reduces Histamine Release New benefits of Palmitoylethanolamide continue to be discovered, leaving some scientists perplexed. It turns out that Palmitoylethanolamide can also activate the cannabinoid receptors, improve mood, reduce allergies.

Where can we get the best quality Palmitoylethanolamide?

Palmitoylethanolamide Powder wholesale trades are much more common than retail sales as it is usually purchased in bulk directly from the PEA Powder manufacturer factory. Generally, medications of such private nature are commonly bought online as it provides patients with discretion and privacy that they need. The medication is available in almost all of the local and online pharmacies.

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