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Sulforaphane Supplements: Defination, Benefits, Side Effects & Food Source
1. What is sulforaphane? Sulforaphane (SFN) is a compound rich in sulfur that is found in cruciferous vegetables such as cabbage, broccoli, and bok choy. Sulforaphane products have been proved to offer you powerful health positive effects. In these foods, sulforaphane is found in an inactive form called glucoraphanin which belongs to the plant family of glucosinolate compounds.
Sulforaphane and glucoraphanin Sulforaphane (SFN) is activated when glucoraphanin gets into contact with myrosinase. Myrosinase is a family of enzymes that play a major role in the plant’s defence response. These enzymes are only
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produced and stimulated when a crop is damaged. As a result, cruciferous vegetables should be chopped, cut, or chewed in order to release myrosinase and stimulate sulforaphane.
Sulforaphane and glutathione Sulforaphane blocks Primary Human T-Cell’s inflammatory responses by depleting Glutathione and Increasing ROS. That’s basically how sulforaphane and glutathione relate. The function and action of T-cells are influenced by the extra- and intracellular redox milieu. In a study to investigate how sulforaphane affected the health of the liver, Sulforaphane and glutathione were seen to interact to cause positive effects in the liver health of rats. Broccoli sprouts were seen to activate glutathione production and detoxification, boosting GST while lowering ALT and AST in the livers of rats.
2. How does sulforaphane work? Sulforaphane has been shown to cause cancer prevention effects by stimulating a transcription factor known as Nrf2 (nuclear factor (erythroid-derived 2)-like 2). Nrf2 regulates the balance of oxidation by reducing oxidation in your body cells, and by improving the anti-oxidation ability of your body. Nrf2 when stimulated also increases the ability of your body to detoxify chemical compounds taken into your body. It is known that a reduction in the balance of oxidation due to obesity and hyper nutrition may lead to several diseases. Sulforaphane works to enhance the balance of oxidation and also downregulates obesity and hyper nutrition. By so doing, sulforaphane is able to protect the body against several other diseases.
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3. Sulforaphane benefits? Sulforaphane benefits results from the ability of sulforaphane to regulate the balance of oxidation. It does so by decreasing oxidation in the cells, and by increasing the anti-oxidation ability of your body. Sulforaphane benefits therefore include;
Aiding Weight Loss
Fighting Cancer Cells
Kills Toxins
Improves the Health of The Heart
Have Powerful Antiviral Activities
Fights Diabetes
Improves the Brain Function
May Lower Constipation
Decreases Symptoms of Autism
Improves the Functioning Of the Liver
Improves the Health of the Eyes
Improves Brain Function
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Now let’s discuss the above functions in details;
I. Weight loss A diet rich in vegetables is one of the most obvious suggestions for weight loss. Vegetables are generally high in nutrients and low in calories and are considered crucial to a healthy lifestyle. Sulforaphane contributes to weight loss by reducing the amount of visceral fat. Sulforaphane supplements also increases browning of adipose tissue stimulating burning of more fat. SNF also lowers the level of cholesterol, liver triglyceride, and improves glucose tolerance and insulin resistance. In simpler terms, sulforaphane fights obesity by changing your body’s energy consumption and by improving gut flora.
II. Sulforaphane Fights cancer cells It is important to know that brassica vegetables assist in protection against cancer. Eating just three to five servings per week lowers risk of cancer by 30 to 40 percent. This great decrease in the risk of cancer is the main reason why you need to take these vegetables daily. However, there are many other cancer-protective advantages as well. Sulforaphane fights cancer cells while strengthening healthy mitochondria at the same time. Also, sulforaphane powder detoxifies carcinogens and destroys cancer cells. SFN also prevents against the growth of tumour. Research has shown that sulforaphane assists in destroying cancer in men, too. The results of sulforaphane powder in cancer treatment are so highly promising that drug companies are testing Sulforadex drug, for its use in the treatment of cancer. Sulforadex drug is a synthetic form of sulforaphane.
III. Sulforaphane antioxidant kills toxins Phytochemicals such as sulforaphane are powerful antioxidants. Sulforaphane antioxidant is very effective in destroying free radicals. Free radicals are small particles that damage and weaken healthy cells. They normally form in our bodies because of various factors. This factors include pollution, food
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additives, UV rays, and preservatives. Free radicals may also form through natural processes such as digestion.
IV. Sulforaphane improves the health of the Heart Sulforaphane may improve the health of your heart in several ways. For example, sulforaphane may help improve the health of your heart by lowering inflammation. Inflammation can cause narrowing of arteries which is one of the major causes of heart disease. Sulforaphane broccoli powder may also lower high blood pressure. Reducing high blood pressure may prevent you from heart diseases.
V. Sulforaphane Shows Powerful Antiviral Activities Sulforaphane broccoli powder has shown powerful antiviral activities when cells which are infected are directly exposed. However, there is no enough evidence currently to support its application in people with viral infections. Sulforaphane broccoli powder lowers influenza viral load. Taking sulforaphane products also improves the antiviral action of immune cells in human beings.
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VI. Sulforaphane Shows Diabetes Fighting Effects Type II diabetes is one of the most common chronic diseases affecting many people worldwide. People with type II diabetes cannot transport sugar from their blood effectively to their cells. This makes it extremely hard to maintain a healthy blood sugar level. Sulforaphane lowers the levels of fasting blood sugar effectively by 6.5 per cent. The positive effects are specifically stronger in people who are overweight. Sulforaphane benefits on the control of blood sugar levels are also supported by several animal studies.
VII. Sulforaphane Improves Our Brain Function Sulforaphane is also excellent for the brain. It is one of the most popular a nootropic because it can cross the blood-brain barrier. Sulforaphane powder has been seen to help the brain in animals in several ways. To start with, the intake of glucoraphanin myrosinase during the adolescent and juvenile periods prevented against the start of cognitive deficits in adulthood.
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Glucoraphanin blocked brain swelling in mice, reducing pro-inflammatory cytokines levels. Glucoraphanin myrosinase also prevented against impairment of memory in diabetic mice. Glucoraphanin myrosinase provided protection against brain damage caused by acute CO poisoning in mice. In cell research, Sulforaphane powder also provided protection to neurons from humans against prion-mediated neurotoxicity.
VIII. Sulforaphane Improves The Health of Our Eyes Excessive light exposure may lead to oxidative stress which can cause several human retinal disorders by increasing the death of photoreceptor cells. A photoreceptor is a cell that receives light and translates it into a nerve impulse. Sulforaphane protects human retinal cells against induced damage by UVA light. Treatment by Sulforaphane significantly lowered ischemia (lowered blood and oxygen flow.) This condition causes loss of retinal functionality in humans. Sulforaphane protected lens cells in humans against oxidative stress. Furthermore, Sulforaphane may assist in prevention against complications after cataract surgery.
IX. Sulforaphane Improves the Functioning of the Liver In humans with fatty liver, sulforaphane products enhances the functioning of the liver and lowered γ-GTP, ALP, and ALT. In animals, glucoraphanin protected against a broad variety of liver illnesses caused by high-calorie diets, toxic chemicals, alcohol, and drugs. Several drugs such as sodium valproate may cause toxicity in the liver. In mice, glucoraphanin myrosinase significantly enhanced the functioning of the liver lowered ALP, ALT, and AST. This compound also improved valproate-induced damage of the liver.
X. Sulforaphane Supplements Decreases symptoms of autism
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Placebo-controlled, double-blind research in men with autism found that SFN supplements lowered autism symptoms. These symptoms include hyperactivity, lethargy, stereotypy, and irritability. Participants consumed the equivalent of several servings of broccoli per day. This amount worked well for them.
XI. Sulforaphane May Lower Constipation Taking 20 grams of broccoli sprouts per day lowers the symptoms of constipation in people suffering from the same.
4. Sulforaphane side effects Sulforaphane side effects are clearly not one of the most important concerns that you should consider before taking SFN. Taking sulforaphane dosage in amounts equal to what is present in cruciferous vegetables is safe. Such an amount shows very few if any sulforaphane side effects. Also, sulforaphane powder bulk amounts are available for sale at various websites and health food stores as supplements or for use in research and drug development. These sulforaphane products are also considered safe. These sulforaphane supplements are always extracted from broccoli sprout and are always concentrated, meaning that they contain more SFN than what is found in food naturally. Glucoraphanin which is the precursor to SFN is also available in the form of supplements combined with myrosinase for activation. Glucoraphanin myrosinase is marketed as a way of boosting production of sulforaphane in the body. This combination doesn’t show any serious side effects too. While we have no sulforaphane dosage clinical recommendations, most supplement brands recommend taking around 400 mcg daily. This typically equals to one to two capsules. However, mild sulforaphane side effects have been seen. They include:
Diarrhea
Constipation
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Increase in gas
5. Where can you find sulforaphane? Broccoli and other cruciferous vegetables are very rich in sulforaphane. SFN is very effective when broccoli is sprouting before maturing into the plant you normally see in your grocery shop. Activated Sulforaphane Supplements are also rich in SNF. In summary, listed below are the food sources of sulforaphane:
Activated Sulforaphane Supplements
Broccoli Sprouts
Cauliflower
Kales
Other Brassicas such as Brussels sprouts and cabbages
6. Sulforaphane Supplements If you don’t have the time to get your sulforaphane dosage from natural foods, SFN supplements are an easy and quick way to acquire your daily dose of this important phytochemical. Sulforaphane 9
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Supplements are usually extracted from broccoli sprouts and are usually concentrated to ensure they have more SFN phytochemical than what you can get from food naturally. The estimated Sulforaphane Supplement dosage in humans is:
11 to 57 mg for a person weighing 250 lb
9 to 45 mg for a person weighing 200 lb
7 to 34 mg for a person weighing 150 lb
To make sure you get your quick sulforaphane dosage, you can look for sulforaphane supplements in online sellers, health food stores, or from our website.
7. Where to buy sulforaphane powder? If you are looking to buy sulforaphane powder, look for a certified manufacturer who has the knowledge, expertise and the high-end equipment needed in the production of high-quality phytochemical compounds. You should make sure that you’re sourcing sulforaphane powder from a trustworthy and reputable seller to avoid buying a low-quality product. You can also order sulforaphane powder from us for your research or supplement production. We have the ability to process sulforaphane powder bulk orders quickly and deliver to the U.S., Europe, Asia, and several other parts of the globe.
8. Sulforaphane VS glucoraphanin Glucoraphanin is basically defined as the precursor to sulforaphane. Sulforaphane, on the other hand, is an effective natural inducer of Phase II detoxification enzymes, which destroys several types of environmental pollutants, free radicals, and trigger continuous antioxidant actions. Myrosinase enzyme is needed to aid in the conversion of glucoraphanin to sulforaphane. Also, there’s scientific evidence that supports sulforaphane production from glucoraphanin by gut microflora, New research from Johns Hopkins University School of Medicine shows that sulforaphane bioavailability from commercial glucoraphanin supplement is equal to that seen in broccoli sprouts,
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References [1]Atwell LL, Zhang Z, Mori M, Farris PE, Vetto JT, Naik AM, et al. Sulforaphane bioavailability and chemopreventive activity in women scheduled for breast biopsy. Cancer Prevent Res. (2015) 8:1184–91 [2]Houghton, C. A.; Fassett, R. G.; Coombes, J. S. (2013). “Sulforaphane: Translational research from the laboratory bench to clinic”. Nutrition Reviews. 71 (11): 709–26. [3]Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, et al. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J Biol Chem. (2004) 279:25813–22. [4]Manish Kumar Tiwari, Nihar Ranjan Jena, Phool Chand Mishra. Mechanisms of scavenging superoxide, hydroxyl, nitrogen dioxide and methoxy radicals by allicin: catalytic role of superoxide dismutase in scavenging superoxide radical. Journal of Chemical Sciences 2018, 130
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