XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com1 WhatarethebenefitsofSpermine? Reproducefrom: https://www.phcoker.com/ourproducts/spermine/ Spermineandpolyamines....................................................................................2 WhatisSpermine?...............................................................................................2 Whatissperminetetrahydrochloridepowder?....................................................3 SpermineMechanismofaction:Howdoesitwork?............................................3 Sperminebenefits-Whatisspermineusedfor?..................................................4 SpermineandSpermidine....................................................................................6 Sperminetetrahydrochloridepowderapplication................................................7 WheretobuySperminebulk?..............................................................................7 FAQ 8
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com2 Spermineandpolyamines Sowhatarepolyamines?Andwhyaretheysoimportantintheroleofaging?Polyaminesare presenteverywhereinlivingcellsandtissues.Theyareknownasbiogenicamineswhichare compoundswithmorethantwoaminogroups.Polyaminesoccurnaturallyinourbodiesand unfortunately,asweagetheselevelsdecrease. Polyaminesplayarolein: Celldivisionanddifferentiation Cellproliferation DNAandproteinsynthesis Homeostasis(thebody’sabilitytoadjustandmaintainastablestate) Andgeneexpression(thecodeofageneusedtodirectproteinsynthesis) Lookingatallthefunctionsofpolyamines,wecanseewhyweshouldbeconcernedifagingcauses ourlevelstodrop.Theseessentialcompoundsseemtobeveryinvolvedintheprocessesofcell growthandmaintaininggeneticstabilityThey,therefore,helpslowtheprocessofgrowingolder andimproveourlifespanandourhealthspan(ourqualityoflife).Thedropinourlevelsof polyaminesisthereforedenyingussomerichtherapeuticbenefits Themainpolyaminesfoundinmammaliancellsandevenplantsarespermidine,spermine,and putrescine.Humansandplantshavemanythingsincommon,oneofthosethingsisthatwebothdo allthatwecantoensureweliveaslongaspossible.Oneofthewayswecanachievethatisthrough theintakeofpolyaminesandpolyaminesynthesisThisprocesspromotesautophagy,whichisour body’sprocessofreplacingdamagedcellswithnew,rejuvenatedcells.Asyoucanimagine,this processcanhelpuslivealonger,happier,healthierlifeSpermineisanexampleofapolyaminethat canhelppromoteautophagy. WhatisSpermine? Spermineisanaturallyoccuringpolyaminethatoccursinalleukaryotes,butisrarein prokaryotes.Itisessentialforcellgrowthinbothnormalandneoplastictissue. Spermineisformedthroughtheadditionofaaminopropylgrouptospermidineby sperminesynthase.Spermineisstronglybasicincharacter,andinaqueoussolutionat
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com3 physiologicalpH,allofitsaminogroupswillbefoundasapolycation. Sperminemaybeusedinawidevarietyofbiologicalapplicationsasasupplementor regulatoryagent.UsedascomatrixwithDHBforMALDIMSofsialylatedglycansin negativeionmode. Whatissperminetetrahydrochloridepowder? Sperminetetrahydrochlorideisapolyaminewhichproducesavarietyofmodulatory effectsontheNMDAreceptorchannel,actingthroughaspecificsiteonthecomplex whichcancausebothagonistandantagonisteffects.Sperminetetrahydrochloride powderisthetetrahydrochlorideformofSpermine.Sperminetetrahydrochloride powderiswhitepowderformwhileSperminefreebaseisinliquidform.Spermine tetrahydrochloridepowderbenefitsaresamewithSperminebenefits. SpermineMechanismofaction:Howdoesitwork? Spermineisderivedfromspermidinebysperminesynthase.Spermineisapolyamine, asmallorganiccationsthatisabsolutelyrequiredforeukaryoticcellgrowth. Spermine,isnormallyfoundinmillimolarconcentrationsinthenucleus.Spermine functionsdirectlyasafreeradicalscavenger,andformsavarietyofadductsthat preventoxidativedamagetoDNA.OxidativedamagetoDNAbyreactiveoxygen speciesisacontinualproblemthatcellsmustguardagainsttosurvive.Hence, spermineisamajornaturalintracellularcompoundcapableofprotectingDNAfrom
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com4 freeradicalattack.Spermineisalsoimplicatedintheregulationofgeneexpression, thestabilizationofchromatin,andthepreventionofendonucleasemediatedDNA fragmentation. Sperminebenefits-Whatisspermineusedfor? Spermineisanendogenouspolyaminebearingmultipleaminogroups.Ithasbeen foundtoplayimportantrolesincellularmetabolisminalleukaryoticcells.Spermine, anaturallyoccurringpolyamine,hasrecentlyemergedasexhibitingantiaging properties.SperminesupplementsmadebySperminetetrahydrochloridepowder increaseslifespanandresistancetostress,anddecreasestheoccurrenceof agerelatedpathologyandlossoflocomotorability. Spermineamelioratememoryretentionloss. AfterthetreatmentofSpermine,theabilityofmemoryretentionwasgreatly improvedinSAMP8mice.Sperminetetrahydrochloridepowdersignificantly improvedthetimedurationofexploringthenovelobject. Sperminealleviatesoxidativestressinthebrainofmice. WeevaluatedtheeffectofpolyamineandrapamycinonoxidativestressSpermine decreasedthelevelsofMDAinthebrainofSAMP8miceTheactivityofSODwas particularlyincreasedinthegroupofspermine.TheseresultsindicatedthatSpermine
group Spermineinduceautophagy
Theexpressionofneurotrophicfactorsandsynapticproteinsweredetectedin sperminegroup.Nervegrowthfactor(NGF),brainderivedneurotrophicfactor (BDNF),postsynapticdensityandpostsynapticdensitywasobviouslyimprovedinthe groupofspermine.
Asresultshown,theexpressionofproteinsrelatedtomitochondrionweregreatly improvedinsperminegroup.Spermineobviouslyinducedthephosphorylationof DRP1.TheconcentrationofATPwaslowerinSAMP8micegroupthaninspermine
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AfterthetreatmentofSperminetetrahydrochloridepowder,thelevelof phosphorylationofAMPKwaselevated.Thelevelofproteinsrelatedtoautophagy
Spermineredressmitochondrialdysfunction
includingwassignificantlyincreasedinsperminegroup.
tetrahydrochloridepowdergreatlyameliorateoxidativestressinSAMP8. Spermineincreasesynapticplasticityandneurotrophicfactors
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com6 Spermineameliorateapoptosis Spermineattenuateinflammation Asresultshown,Afterthetreatmentofspermine,theexpressionofinflammatory proteinsweredecreasedsharply.sperminesupplementsmakebySpermine tetrahydrochloridepowdercoulddepressinflammationinthebrain. SpermineandSpermidine Thecontentofspermidineandspermineinmammaliancellshasimportantrolesin proteinandnucleicacidsynthesisandstructure,protectionfromoxidativedamage, activityofionchannels,cellproliferation,differentiation,andapoptosis. Spermineisanothertypeofpolyamine.Bothcompoundsarerelatedtoeachother. SpermineisderivedfromSpermidineandiscrucialforcellmetabolisminhuman beingsandplants.Takingspermidinesupplementsensuresthatyougetspermine benefitstoo.
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com7 Sperminetetrahydrochloridepowderapplication SperminetetrahydrochloridepowderwasusedtoprecipitateDNAforflowcytometric analysisfromfreshfrozenbreastcancertissue,archivaltissueofsalivarygland,renal andthyroidtumors2andredbloodcellsofchicken.NowSpermine tetrahydrochloridepowderhasusedinanti-agingsupplements.BuySpermine tetrahydrochloridepowderonline. WheretobuySperminebulk? Inthemodernworld,youcanbuySperminesupplementsmakebySpermine tetrahydrochloridepowderatthecomfortofyourhomeonlineHowever,youwill havetocheckwidelyforhighqualitySperminetetrahydrochloridepowdersuppliers CustomerreviewsareonewaytoguaranteetheSperminetetrahydrochloridepowder benefitsandalsogatherinformationonpossiblesperminesideeffects. Therearemanysperminetetrahydrochloridepowderforsaleinthemarket.Phcoker asamanufacturingfactoryofferswholesalequantitysperminetetrahydrochloride powder.Thebestsperminesupplementpowderiswithhighpurityandbioavailability. Sperminetetrahydrochloridepowderwholesalebuywillgetgoodprice.
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com8 FAQ IsSpermineAntiaging? Apaperpublishedin1992hypothesizedthatspermineandspermidineprotectDNA againstfree-radicaloxidativedamage.OurSperminelevelsdropasweage,whichis notgoodnewstousaswemaylosethoseanti-agingandhealthbenefits.Inone experiment,transgenicmicethatcouldnotproducespermineandspermidinelost theirhair,gainedwrinklyskin,anddiedyoungerthannormalmice,butnothing appearedpathologicallyawryinanyoftheorgans Isspermineanantioxidant? Accordingtosomeresearchs,spermineadministrationcanincreasetheantioxidant capacityintheliverandspleenandcanenhancetheantioxidantstatusinthespleen andliverunderoxidativestress.Sperminehasbeenidentifiedasapotentantioxidant andanantiinflammatoryagent.Thecompoundispresentinallorganismsandall organs. Whatdoessperminedoinsperm? Sinceprecisetimingofcapacitationandtheacrosomereactionarecriticalfor successfulfertilization,itissuggestedthattheroleofseminalspermineistoprevent prematurecapacitationandtheacrosomereaction.
XuchangshangkeChemicalCo.,Ltd Phcoker wwwphcokercom Email:info@phcoker.com9 Whereissperminefound? Spermineisapolyamine,asmallorganiccationsthatisabsolutelyrequiredfor eukaryoticcellgrowth.Spermine,isnormallyfoundinmillimolarconcentrationsin thenucleus.Sperminefunctionsdirectlyasafreeradicalscavenger,andformsa varietyofadductsthatpreventoxidativedamagetoDNA. Isspermineaprotein? Althoughspermidinehasanessentialanduniqueroleastheprecursorofhypusinea posttranslationalmodificationoftheelongationfactoreIF5A,whichisnecessaryfor thisproteintofunctioninproteinsynthesis,nouniqueroleforsperminehasbeen identifiedunequivocally. Howdoyoustoresperminesolution? Storeat28°CSolutionsofsperminefreebasearereadilyoxidizedSolutionsare moststableifpreparedindegassedwaterandstoredinfrozenaliquots,underargon ornitrogengas.sperminetetrahydrochloridepowderismorestableformofspermine freebase. Wheredoessperminecomefrom? Spermineispresentinmanyorganismsincludinganimals,plants,somefungi,some archaea,andsomebacteria.Itissynthesizedbysperminesynthase,ahighlyspecific
ToconfirmthatsperminewasbiologicallyactiveatpH7.4wetesteditseffectson
aminopropyltransferase.Spermineisderivedfromspermidinebysperminesynthase. WhatisthepHofspermine? heterologouslyexpressedglutamatereceptors(GluR3) Isspermgoodforskin? Infact,thereisn'tanyscientificevidencetobackuptheideaofputtingsemenon yourskin.Asidefromdoinglittletohelpyourcomplexion,itcanalsoresultinallergic reactionsandsexuallytransmittedinfections(STIs).
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1.Oneoftheclaimsofthebenefitsofspermforfacialskinisthetreatmentofacne. Thebenefitsofspermforbeautyarebelievedtocomefromthesubstancespermine. Spermineisaderivativeofthesubstancespermidineinmalesemen,whichis believedtoactasan antioxidantandantiinflammatoryagent.Inadditiontomalesperm,sperminecan alsobefoundinthecellsofthehumanbody.Spermineisbelievedtotreatacneand fightacnescars. Unfortunately,therearenoscientificresearchresultsthatcanprovethebenefitsof spermforacne-proneskin.
2.ClaimsThebenefitsofspermforbeautyaretopreventtheappearanceofsignsof prematureaging,suchaswrinklesorfinelines.Onceagain,theclaimofthebenefits ofspermforthefaceofwomenarisesbecausespermcontainspermine.Spermineis believedtobeanantioxidantcapableofdisguisingthesignsofaging,suchaswrinkles andfinelines,makingtheskinlookyounger.AstudypublishedinthejournalNature CellBiologysaysthatspermineisabletoslowdowntheagingprocesswhenusedby injectingitdirectlyintohumanskincells. However,thebenefitsofspermfortheface,whichisusedbyapplyingitdirectlyto theskinsurface,arestillnotproven.Thatis,thebenefitsofspermforthefaceof womeninthepreventionofprematureagingarejustamyth.
Reference: 1.TingTingXu,HanLi,ZhaoDai,GeorgeK.Lau,BenYueLi,WenLiZhu,XiaoQiLiu, HaoFeiLiu,WeiWuCai,ShuiQingHuang,QiWang,ShiJieZhang.“Spermidineand sperminedelaybrainagingbyinducingautophagyinSAMP8mice”Published:April8, 2020.https://doi.org/10.18632/aging.103035 2.Galluzzietal(2017)Pharmacologicalmodulationofautophagy:therapeutic
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5.TseRT,WongCY,ChiuPK,NgCF.“ThePotentialRoleofSpermineandIts AcetylatedDerivativeinHumanMalignancies.IntJMolSci.2022Jan23;23(3):1258. doi:10.3390/ijms23031258.PMID:35163181
6.Sadeghi-KajiS,ShareghiB,SabouryAA,FarhadianS.“Spermineasaporcine pancreaticelastaseactivator:spectroscopicandmolecularsimulationstudies.”J BiomolStructDyn2020Jan;38(1):7888doi:101080/0739110220191568306 Epub2019Feb27PMID:30810494
3.HasanMM,SkalickyM,JahanMS,HossainMN,AnwarZ,NieZF,AlabdallahNM, BresticM,HejnakV,FangXW.“Spermine:ItsEmergingRoleinRegulatingDrought StressResponsesinPlants.”Cells.2021Jan28;10(2):261.doi:10.3390/cells10020261.
4.GrancaraS,MartinisP,ManenteS,GarcíaArgáezAN,TemperaG,BragadinM, DallaViaL,AgostinelliE,ToninelloA.“Bidirectionalfluxesofspermineacrossthe mitochondrialmembrane.”AminoAcids.2014Mar;46(3):6719.doi: 10.1007/s0072601315910.Epub2013Sep17.PMID:24043461
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potentialandpersistingobstacles.Nat.Rev.Drug.Discov.PMID:28529316