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Ursodeoxycholic acid (128-13-2) Specifications Product Name
Ursodeoxycholic acid powder
Chemical Name
(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy10,13-dimethylhexadecahydro-1H-cyclopenta[a]phena nthren-17-yl)pentanoic acid
Synonym
UDCA; Ursodiol; Tauroursodiol;Urosodeoxycholic Acid; Ursodeoxycholic acid(micronized); URSODEOXYCHOLIC ACID; URSODESOXYCHOLIC ACID; URSODEOXYCHOLOC ACID;
CAS Number
128-13-2
InChIKey
RUDATBOHQWOJDD-UZVSRGJWSA-N
Molecular Formula
C24H40O4
Molecular Weight
392.57
Monoisotopic Mass
392.29265975
Melting Point
203-204 °C (lit.)
Boiling Point
437.26°C (rough estimate)
Density
0.9985 (rough estimate)
Color
White - almost white
Solubility
ethanol: 50 mg/mL, clear
Storage Temperature
2-8°C
Application
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response.
Testing Report
Available
History Ursodeoxycholic acid (ursodiol) is a naturally occurring bile acid found in the bile of the Chinese black bear. Black bear bile has been used for many years by practitioners
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of Eastern medicine and has been commercially synthesized and available for use as a hepatoprotective agent in Japan since the 1930s. Since the 1970s ursodeoxycholic acid has been used in Western human medicine for dissolution of gallstones. More recently, it has been used in the management of chronic hepatic diseases in humans such as primary biliary cirrhosis, biliary disease secondary to cystic fibrosis, intrahepatic cholestasis of pregnancy, nonalcoholic steatohepatitis, idiopathic chronic hepatitis, autoimmune hepatitis, primary sclerosing cholangitis and alcoholic hepatitis. However, its therapeutic efficacy in some of these disorders has not been firmly established.
Ursodeoxycholic acid was approved for use in the United States in December 1987, and was designated an orphan drug. It is the only FDA approved drug to treat primary biliary cirrhosis.
Ursodeoxycholic acid goes by the trade names Actigall, Ursosan, Ursofalk, Urso, and Urso Forte. In Italy and Switzerland, it is marketed under the name Deursil. Ursodeoxycholic acid currently on the market mainly appears in the form of tablets, capsules, liquids and powders, and is also sold in the United States, China, Japan and some European countries.
What is Ursodeoxycholic Acid(UDCA) Powder? Ursodeoxycholic acid (UDCA), also known as ursdiol, is a secondary bile acid produced 2
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by gut bacteria in the human body and most other species. It is synthesized in the liver of certain species and was first found in bear bile. It is used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. It can be used as a general medicine.
As an epimer of chenodeoxycholic acid, the administration of ursodeoxycholic acid powder changes the composition of bile and may dissolve gallstones. It is used as a choleretic and choleretic.
Ursodeoxycholic acid powder is used to treat small gallstones in people who cannot have gallbladder surgery, and to prevent gallstones in overweight patients undergoing rapid weight loss.
Ursodeoxycholic Acid Powder Mechanism of Action Ursodeoxycholic acid powder is used in the liver through a variety of complex and 3
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complementary mechanisms, including altering the bile acid pool, acting as a cytoprotective agent, immunomodulatory substance, and choleretic agent. In addition, UDCA significantly reduces bile cholesterol saturation by inhibiting the absorption of cholesterol in the intestine and its secretion into bile, which can be demonstrated by the cholesterol partial reduction of bile lipids.
Choleretic effect Ursodeoxycholic acid reduces elevated liver enzyme levels by promoting bile flow through the liver and protecting liver cells. The main mechanism is anti-gallstone. Although the exact process of ursodiol's anti-gallstone effect is not fully understood, it is believed that the drug concentrates in bile and reduces bile cholesterol by inhibiting the synthesis and secretion of cholesterol by the liver and inhibiting its intestinal absorption. The reduced cholesterol saturation allows the cholesterol in gallstones to gradually dissolve, causing them to eventually dissolve.
Immunomodulatory effect Ursodeoxycholic acid powder has also been experimentally proven to inhibit immune response, such as immune cell phagocytosis. Long-term exposure and/or increased amounts of ursodeoxycholic acid throughout the body (whole body, not just the digestive system) may be toxic.
Anti-inflammatory effect 4
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Ursodeoxycholic acid has been shown to have anti-inflammatory and protective effects on human gastrointestinal epithelial cells. It has been linked to the regulation of the immune regulatory response through the regulation of cytokines, antimicrobial peptide defensins, and has taken an active role in increasing the return of wounds in the colon. In addition, the role of UDCA powder has been shown to work outside the epithelial cells. Although some bile acids are known to be colon tumor promoters (such as deoxycholic acid), others such as ursodeoxycholic acid are believed to have chemopreventive effects, possibly by inducing cell differentiation and/or cell senescence of colonic epithelial cells.
It should be noted that it has almost no effect on calcified gallstones or light-permeable gallstones, and the treatment is only effective for patients with functional gallbladder.
The Benefits & Effects of Ursodeoxycholic Acid Powder Ursodeoxycholic acid is currently the only confirmed drug for the treatment of chronic cholestatic liver disease, and it has been suggested to be an adequate treatment of bile reflux gastritis.
UDCA has cell protection, anti-apoptosis, membrane stabilization, anti-oxidation and immune regulation effects. It is also effective for primary sclerosing cholangitis, 5
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primary biliary cholangitis, intrahepatic cholestasis of pregnancy, liver disease related to cystic fibrosis, chronic graft versus host disease, total parenteral nutrition-related cholestasis, and various pediatric cholestasis Sexual liver disease has beneficial effects.
In addition, ursodeoxycholic acid dissolves or prevents cholesterol gallstones by preventing the production of cholesterol in the liver and reducing bile cholesterol. It also has the effects of improving the bile flow of newborns with impaired blood flow, anti-inflammatory and immune regulation.
UDCA has also been in effective in non-alcoholic fatty liver disease, in liver bile duct-paucity syndromes. However, it is contraindicated in obstruction of biliary tracts such as biliary atresia. It's not effective in liver allograft rejection, and in Graft-versus-host disease involving the liver.
Drug Interactions of Ursodeoxycholic Acid Powder Although Ursodeoxycholic acid is effective in treating or preventing many liver or bile duct diseases, it may be a interaction with other drugs (including prescription and over-the-counter drugs, vitamins and herbal products) when used together. Such as: -Aluminum-containing cholestyramine,
antacids,
clofibrate,
contraceptives,
colestipol),
and
cholesterol estrogen
may
drugs
(such
combine
as with
ursodeoxycholic acid to reduce its efficacy. 6
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-Ursodeoxycholic acid dissolves faster in bile and pancreatic juice; therefore, taking it with food can improve absorption and is recommended.
In addition, you should also pay attention to the use of cholesterol lowering medicines, absorbents, Cyclosporin, Ciprofloxacin and dapsone.
The above is just a short list of drugs. Therefore, it is best to check with your/your child’s doctor or pharmacist before giving any prescription medicine.
The Side effects of Ursodeoxycholic Acid Powder In addition to its desired effects, ursodeoxycholic acid may cause some adverse effects. Although not all of these side effects can occur, if they do occur, they may require medical attention.
If any of the following side effects occur, consult your doctor immediately: - Headache, dizziness; - Mild stomach pain or discomfort; - Nausea, vomiting, diarrhea, constipation; - Cough, fever, sore throat, runny nose or other signs of infection - Hair loss; - Back pain, muscle pain; - Joint swelling, pain or stiffness; 7
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- Mild itching or rash;
Tell your doctor right away if any of these unlikely but serious side effects occur: - Weakness - Swelling of the ankles/feet - Increased thirst/urination - Signs of infection (e.g., fever, persistent sore throat) - Easy bleeding/bruising
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention
if
you
notice
any
symptoms
of
a
serious
allergic
reaction,
including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Where is Ursodeoxycholic Acid Powder Sold? Ursodeoxycholic acid powder wholesale trades are much more common than retail sales as it is usually purchased in bulk directly from the ursodeoxycholic acid powder manufacturer . Generally, medications of such private nature are commonly bought 8
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online as it provides patients with discretion and privacy that they need. And maybe you can find it at your local pharmacy, usually in tablet and capsule form. But whether you buy it online or pharmacy, you should take care to take the appropriate dose as recommended by your supplier or doctor, and should not be missed or overdose.
More Information Ursodeoxycholic acid has been found that it can reduce cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want to replace surgery from previous studies. However, this drug is very expensive, and if the patient stops taking it, the gallstones will recur if the conditions that caused the formation of gallstones have not changed. For these reasons, it does not replace the surgical treatment of cholecystectomy. But it is currently the only drug approved by the FDA for the treatment of primary biliary cirrhosis. In addition, ursodeoxycholic acid has also been studied in veterinary medicine, which has been used to treat dogs with chronic hepatitis and cats with lymphocytic plasma cell cholangitis. Although its efficacy in veterinary patients has not been determined, it is considered to be most beneficial for diseases where bile toxicity plays an important role in ongoing pathology.
Reference: [1] "2020 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 23 9
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February 2021. Retrieved 25 September 2021. [2] Ursodiol: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 25 September 2021. [3] McCabe ME, Dilly CK (September 2018). "New Causes for the Old Problem of Bile Reflux Gastritis". Clinical Gastroenterology and Hepatology. 16 (9): 1389–1392. doi:10.1016/j.cgh.2018.02.034. hdl:1805/15771. PMID 29505908. [4] Guarino MP, Cocca S, Altomare A, Emerenziani S, Cicala M. Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed. World J Gastroenterol. 2013 Aug 21;19(31):5029-34. [5] Roma MG, Toledo FD, Boaglio AC, Basiglio CL, Crocenzi FA, Sánchez Pozzi EJ. Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications. Clin Sci (Lond). 2011 Dec;121(12):523-44. [6] D Kumar, R K Tandon. Use of ursodeoxycholic acid in liver diseases. Gastroenterol Hepatol. 2001 Jan;16(1):3-14. doi: 10.1046/j.1440-1746.2001.02376.x. [7] Beuers UBJ, Paumgartner G. Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications. Hepatology. 1998;28:1449–53. [8] Paumgartner GBU. Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology. 2002;36: 525–31.
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