Fall 2022 Anthony Jewett Student pharmacist Anabolic Steroids

History Slang

The first anabolic steroids were synthesized in Germany 1935 to treat hypogonadism. They were later discovered to be used in Soviet powerlifting competitions, and were subsequently banned by the International Olympic Committee in 1975. The Anabolic Steroids Control Act of 1990 placed anabolic steroids as a schedule III drug.

Pharmacology

• Arnolds

• Gym Candy

• Juice

• Pumpers

• Roids

• Stackers

• Weight Trainers

Anabolic steroids are drugs which mimic naturally occurring male sex hormones testosterone and dihydrotestosterone.

These drugs bind to and activate androgen receptors in the body. Anabolic steroid use results in increased protein synthesis and buildup of cellular tissue, especially within muscles.

Drug Interactions and Toxicology

Long-term use and misuse of anabolic steroids causes hepatoxicity, cardiovascular complications, and endocrine system damage.

Anabolic steroids interact with warfarin and increases the risk of bleeding when used in combination. Also, steroid use in addition to cyclosporine is not recommended due to increased risk of hepatotoxicity.