2012 CRS Annual Meeting & Exposition Program Book

CRS 2012 Program

39th Annual Meeting & Exposition of the Controlled Release Society July 15–18, 2012 Centre des congrès de Québec Québec City, Canada

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President’s Welcome to the Annual Meeting Dear Colleagues and Friends, It is my distinct pleasure to welcome you to the 39th Annual Meeting & Exposition of the Controlled Release Society. It is difficult to believe all the hard work put in over the past year will finally culminate in these few days at the meeting, with the opportunities to discover the latest research, build new relationships, and celebrate delivery science and technology.

The CRS Annual Meeting & Exposition is proud to bring together attendees and organizations from around the world. Abstract presenters alone represent 42 countries, and exhibitors will be traveling from Europe, Asia, and North America, creating a truly international gathering in this unique French-speaking province of Canada. As a scientific discipline, we rely strongly on each other’s findings, services, and technologies to advance delivery science and therefore the work each of us does. The CRS Annual Meeting & Exposition offers the perfect venue to mingle with a world’s worth of top scientists.

This year’s meeting features more than 600 posters, over 100 podium speakers, an exposition hall packed with 100+ exhibitors, and much more. Three outstanding plenary speakers will offer their insights into unique topics within delivery science. The meeting will also showcase five mini-symposia, 41 invited speakers, and more than 25 scientific sessions. The popular CRS Innovation Sunday has returned, this year looking at “Game-Changing Innovation” and featuring a panel of top professionals from industry. This is in addition to Soapbox Sessions and Releasing Technology Workshops, highlighting the top companies and products in delivery science. The Roundtable and Get Up! Get Educated! Sessions have also returned, giving you a careerimproving reason to wake up early and get to the meeting.

Martyn C. Davies President Controlled Release Society

I am always in awe of the scientific sessions each year, as they reflect how quickly our science is advancing. The bioactive sessions feature all the latest trends and advances, including DNA and RNAi delivery, biomaterials, nanomedicines, and active and passive targeting. The Consumer & Diversified Products program this year is exceptionally strong, with focuses on nanoparticle technology applications, hydrogel delivery, and smart textiles. As the Veterinary Division morphs into the more inclusive Preclinical Sciences & Animal Health Division, their programming also highlights the latest in that area, including protein and vaccine delivery and therapeutics for animal patients.

You can find the programming and much more on the CRS Annual Meeting Mobile App, available for download again this year and hopefully already on your mobile device! The improved mobile app has schedules, exhibition listing, a personal schedule and to-do list, and also includes CRS Connect. CRS Connect helps you make targeted connections with other meeting attendees through your mobile device and allows you to contact them and set up face-to-face meetings during the CRS Annual Meeting & Exposition.

While the mobile app and CRS Connect offer the latest in technology for networking, if you prefer to do it the “old-fashioned” way, I highly recommend any of the events designed just for that. Join us at the Welcome Reception to meet with your colleagues and find new discoveries with the exhibiting companies. Make new relationships at the Young Scientist Networking Evening, Women in Science Luncheon, C&DP Division Luncheon, or Preclinical Sciences & Animal Health Get-Together. The always entertaining Kinam Park will be the highlight of the evening at the President’s Banquet on Tuesday, a great opportunity to enjoy Québec’s finest cuisine while meeting top researchers.

It has been my pleasure to serve as President of the Controlled Release Society for the past year.

I am very proud of all we have accomplished as a society. I look forward to seeing you here in Québec!

Best Regards, Martyn C. Davies President, Controlled Release Society

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Table of Contents

2012 CRS Program Team Bioactive Materials Program Chairs Hamid Ghandehari University of Utah, U.S.A. Dusica Maysinger McGill University, Canada Consumer & Diversified Products Program Chairs Christopher McDaniel Fleet Laboratories, U.S.A. Teresa Virgallito Mircrotek Labs Inc., U.S.A. Veterinary Program Chairs Arlene McDowell University of Otago, New Zealand Thierry Vandamme University of Strasbourg, France

General Meeting Information ................................................................... 3 Centre des Congrés de Québec Floor Plans .............................................. 6 Schedule-at-a-Glance Saturday – Sunday ................................................................................ 9 Monday ............................................................................................. 10 Tuesday – Wednesday ........................................................................ 11 Daily Schedule Saturday ............................................................................................. 12 Sunday ............................................................................................... 14 Sunday Releasing Technology Workshops ........................................ 17 Sunday Soapbox Sessions .................................................................. 21 Monday ............................................................................................. 23 Tuesday .............................................................................................. 30 Wednesday ......................................................................................... 39 Posters ..................................................................................................... 42 Exposition ............................................................................................... 52 Sponsors .................................................................................................. 61 Acknowledgements ................................................................................. 66

Advertisers’ Index Aptalis Pharmaceutical Technologies ...................................................... 22 www.AptalisPharmaceuticalTechnologies.com Avanti Polar Lipids ........................................................ Inside Front Cover www.avantilipids.com Grünenthal GmbH ................................................................................. 19 www.grunenthal.com OctoPlus NV............................................................................................ 13 www.octoplus.nl Michelson Prize & Grants ...................................................................... 20 www.michelson.foundanimals.org Patheon...................................................................................... Back Cover www.patheon.com Texture Technologies Corp.............................................. Inside Back Cover www.texturetechnologies.com

©Shutterstock

Controlled Release Society CRS Central ............................................................................................ 19 CRS Chapters ......................................................................................... 60 CRS Foundation ..................................................................................... 68 CRS Headquarters & Staff ..................................................................... 25 Drug Delivery and Translational Research .............................................. 38 Job Center ......................................................................................... 15, 31 Membership ............................................................................................ 33 Mobile App ............................................................................................... 5 Publications ............................................................................................. 14 40th Annual Meeting & Exposition of the ............................................. 50 Controlled Release Society

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General Meeting Information The Centre des congrès de Québec is the headquarters for all workshops, sessions, the exposition, posters and the Welcome Reception. All meetings/events not being held at the Centre des congress de Québec are so noted in the Program Book. Please familiarize yourself with the location of the meetings/events you are registered to attend to reduce travel time to these off-site meetings/events.

Registration Desk

WiFi Access

The Registration Desk is located on Floor 4, Main Hall of the Centre des congrès de Québec. The desk will be open:

Co-sponsored by Texture Technologies Corp.

Saturday, July 14 Sunday, July 15 Monday, July 16 Tuesday, July 17 Wednesday, July 18

07:00 – 15:00 07:30 – 18:00 07:00 – 18:00 07:00 – 17:30 07:30 – 12:00

Access the Abstracts CRS Annual Meeting abstracts can be accessed in three ways.

The CRS Annual Meeting Mobile App provides access via your mobile device or laptop; simply click on the Posters icon to begin viewing, or view podium abstracts directly from the schedule. The abstracts are available on the CRS website for all registered attendees to view and search. Both the mobile app and the website can be accessed with WiFi available at the convention center. Attendees may also view and print abstract information at the Abstract Printing Stations located near CRS Central.

Visit CRS Central Be sure to stop at CRS Central this year to see what the CRS membership has accomplished! View the new books, journals, and webcasts, and learn about committees and divisions. Take your time and sign up for the job board or become a part of the new LATTE database. Located on the 4th Floor, Loggia, outside of the Exposition.

New for 2012—CRS Connect Make targeted connections with fellow meeting attendees via CRS Connect on the CRS Annual Meeting Mobile App. Sign into the mobile app using your email address, select the CRS Connect icon, and search through the database of meeting attendees. Once you identify an individual you wish to contact, click on their name to either send them a private message or request an appointment. All of this takes place through CRS Connect while maintaining full privacy, as personal contact information is never shared. CRS has designated an area in the Exposition Hall in which CRS Connect meetings can take place.

CRS 2012 Mobile App Sponsored by Aptalis Pharmaceutical Technologies Access the meeting with the 2012 CRS Annual Meeting Mobile App. Browse the schedule, explore abstracts, create your personal schedule and to-do list, receive announcements, view exhibiting companies, and network with fellow attendees via CRS Connect. Download the CRS 2012 Mobile App by searching for “CRS Meeting” in the iTunes Store or the Android App Store/Google Play.

Reach the mobile app from your Blackberry or laptop via the mobile app website mobileapp.controlledrelease.org.

CRS has contracted with the Centre des congrès de Québec to provide free WiFi service throughout the building during the annual meeting. Access will be available Saturday through Wednesday. Power up your laptop or mobile device to connect to the meeting abstracts, or utilize CRS Connect and the mobile app. Select the following to connect: Network: CRS Access code: AU21H Free WiFi access is also available without an access code at all designated Vidéotron Hot Spots within the Centre des congrès de Québec. See the floor plan on pages 6–8 for hot spot locations. Sessions are limited to 20 consecutive minutes but are renewable all day long. An Internet Café is located on level 3 and provides free access to the internet.

Exposition Hours and Location Exposition Hours and Location The Exposition is located on Floor 4, Hall 400A/B/C, and has dedicated hours when all exhibitors are present at their booths.

The scheduled Exposition activities are as follows: Set-Up Saturday, July 14 08:00 – 17:00

Sunday, July 15 08:00 – 14:00

Exposition Open Sunday, July 15 17:30 – 19:30 Exposition Opening and Welcome Reception Monday, July 16 09:30 – 10:30 Networking Opportunity and Refreshment Break – Redeem your ticket for a

complimentary beverage from the Café.

12:00 – 13:30 Lunch Break – Lunch and coffee available for purchase 16:30 – 17:30 New! Happy Hour and Networking Opportunity – Cash bar service Tuesday, July 17 09:30 – 10:30 Networking Opportunity and Refreshment Break – Redeem your ticket for a complimentary beverage from the Café.

12:00 – 13:30 Lunch Break – Lunch and coffee available for purchase 12:00 – 16:00 Exposition Open 15:00 – 16:00 Networking Opportunity and Refreshment Break – Redeem your ticket for a complimentary beverage from the Café.

Take-Down Tuesday, July 17 16:00 – 18:00 Exhibit Take-Down

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General Meeting Information continued

Poster Sessions

The posters are located in Hall 400A/B/C. All posters will be on display throughout the meeting during the designated hours.

Poster authors will be present during one of three prespecified time slots. All posters must be removed at the time indicated or they will be removed and discarded. The poster viewing area will be secured overnight. Photographing posters is not permitted.

2012 Poster Schedule Sunday, July 15 08:00 – 14:00 Exhibit and Poster Set-Up 17:30 – 19:30 Poster Viewing Hours Monday, July 16 09:30 – 10:30 Poster Session #1 (authors present) 09:30 – 17:30 Poster Viewing Hours 16:30 – 17:30 New! Poster Viewing and Exposition

Happy Hour Tuesday, July 17 07:00 – 16:00 Poster Viewing Hours 09:30 – 10:30 Poster Session #2 (authors present) 15:00 – 16:00 Poster Session #3 (authors present) 16:00 – 17:00 Poster Take-Down

New for 2012—Poster Snapshots Poster Snapshots are three-minute audio recordings that provide a summary preview of poster content. Attendees can listen to a recording prior to attending the poster sessions and while standing in front of a poster. Poster snapshots are submitted by poster presenters and are available through the CRS Annual Meeting Mobile App.

Speaker Preparation Room

Committee Meetings

CRS committees (and others) are invited to schedule meetings by reserving a meeting room at the Registration Desk. A limited number of meeting rooms are available for use Sunday through Wednesday.

Meeting Schedule (as of May 31, 2012) Monday, July 16 Young Scientist Committee/ Mentor-Protégé Subcommittee Finance Committee Marketing Committee

09:30 – 11:00 304B 15:00 – 16:00 304B 17:30 – 18:30 304B

Tuesday, July 17 DDTR Editorial Board 07:00 – 08:00 Chapter Committee 09:30 – 11:30 JCR Editorial Board 12:00 – 14:00

Consumer & Diversified Products Division 16:00 – 17:00 Emerging Issues and Trends Advisory Committee 16:00 – 17:30 Wednesday, July 18 Books Committee Foundation Board

304B 203 Hilton Québec – Courville/ Montmorency 203 304B

07:00 – 08:00 304B 09:00 – 12:00 304B

Photography Photography is not permitted in the session rooms, exhibit hall or poster sessions. Contact CRS staff at the Registration Desk for further clarification.

Room 201A/B

Photo Release

The Speaker Preparation Room is available for PowerPoint previewing and downloading presentation materials. Speakers are to upload presentations one day prior to their presentation date, i.e., if you speak on Monday, July 16, you will upload your presentation on Sunday, July 15. Presenters are not allowed to use their own laptops.

Many photographs will be taken throughout the CRS Annual Meeting & Exposition and are used in CRS electronic and printed promotional materials during the meeting and after it has concluded. By virtue of your attendance, you agree to the Controlled Release Society’s use of your likeness in said promotional media.

The Speaker Preparation Room will be staffed and open as follows: Saturday, July 14 07:00 – 17:00 Sunday speakers upload presentations Sunday, July 15 07:00 – 17:30 Monday speakers upload presentations Monday, July 16 07:00 – 17:30 Tuesday speakers upload presentations Tuesday, July 17 07:00 – 17:30 Wednesday speakers

upload presentations

Electronic Devices

Awards

Meeting and Future Event Literature

CRS will be honoring several awardees throughout the meeting. Awards will be given out at the Monday Opening Session/Award Ceremony and during the three plenary sessions. See daily highlights and the Awards & Recognition Brochure for more information.

Space for the display of promotional materials for future educational meetings is available in CRS Central. Organizers of educational meetings and events may display their materials in this reserved location. Any literature that is left in areas other than the designated location or that does not promote educational meetings will be discarded.

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As a courtesy to other meeting attendees, electronic devices that ring or beep must be operated in silent/vibrate mode during all educational sessions.

Message Board For your convenience, a message board is located in CRS Central. Post a message to a colleague who is at the meeting.

Job openings/resumes may also be posted.

Access the Meeting The 2012 CRS Annual Meeting & Exposition Mobile App Browse the schedule, explore abstracts, create your personal schedule and to-do list, receive announcements, view exhibiting companies, and network with fellow attendees via CRS Connect.

Download the CRS 2012 Mobile App by searching for “CRS Meeting” in the iTunes Store or the Android App Store/Google Play. Reach the mobile app from your Blackberry or laptop via the mobile app website mobileapp.controlledrelease.org.

Sponsored by Aptalis Pharmaceutical Technologies WiFi is available in the Centre des congrès de Québec for all CRS annual meeting attendees.

Use this service free of charge on your mobile device or laptop and access all of the innovative science and networking opportunities of the CRS annual meeting via the mobile app.

Centre des congrès de QuÊbec

On this level: CRS Central CRS Registration Desk Exposition Hall

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Centre des congrès de QuÊbec

On this level: Meetings Plenary Sessions Scientific Sessions Workshops

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Centre des congrès de QuÊbec

On this level: Meetings Scientific Sessions Workshops

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Schedule-at-a-Glance Saturday, July 14 07:00 – 15:00 CRS Registration Open 07:00 – 17:00 Speaker Preparation Room Open 08:00 – 12:00 Educational Workshop: Formulation and Process

Considerations in the Development/Scale Up of Osmotic Dosage Forms* 08:00 – 17:00 Exhibit Set-Up 08:00 – 17:00 Educational Workshop: Critical Appraisal of EPR

Effect and Intratumoral Distribution of Nanomedicine* 08:00 – 17:00 Young Scientist Workshop #1: Mucosal Drug and Gene

Delivery: Barriers and Opportunities 12:00 – 14:00 Leadership Forum

13:00 – 17:00 Educational Workshop: Setting Release Specifications for In Vitro Testing of Controlled Release Dosage Forms*

Floor 4, Main Hall 201A/B 206A Hall 400A/B/C 205A/B 302A/B Hilton Québec Ste. Foy/Portneuf 208A/B

Sunday, July 15 – CRS Innovation Sunday 07:00 – 17:30 07:30 – 18:00 08:00 – 12:00

08:00 – 14:00 09:00 – 10:00 09:00 – 10:00 09:00 – 10:00 10:15 – 11:15 10:15 – 11:15 10:15 – 11:15 10:30 – 12:30 11:30 – 12:30 11:30 – 12:30 11:30 – 12:30 10:00 – 12:00 11:30 – 12:30 12:30 – 14:00

12:30 – 17:30

13:00 – 15:10 13:00 – 17:30 15:30 – 17:30

17:30 – 19:30 17:30 – 19:30

Speaker Preparation Room Open CRS Registration Open Young Scientist Workshop #2: Professional and Self Development for Young Scientists and Protégés—Time Management Exhibit and Poster Set-Up Releasing Technology Workshop: Gattefossé SAS Releasing Technology Workshop: SOTAX Corporation Releasing Technology Workshop: Team Consulting Ltd. Releasing Technology Workshop: Agilent Technologies Releasing Technology Workshop: Catalent Pharma Solutions Releasing Technology Workshop: EMD Millipore Releasing Technology Workshop: OctoPlus and Mirna Therapeutics Releasing Technology Workshop: Ashland Releasing Technology Workshop: Grünenthal GmbH Releasing Technology Workshop: MedinCell SA 2013 Exhibit Selection, Group A First Timers’ Meeting Young Scientist Roundtable: Entrepreneurship: A Journey from Conception to Commercialization Educational Workshop: Preserving and Enhancing Vision via Ophthalmic Drug Delivery* Soapbox Sessions CRS Central Open Industry Roundtable: Game-Changing Innovation Co-Sponsored by Pfizer Exposition Grand Opening and Welcome Reception Poster Viewing Hours

201A/B Floor 4, Main Hall 302A/B Hall 400A/B/C 202 205C 303A 303A 202 205C 303B 205C 202 303A 203 204A/B 302A/B 205A/B 301A/B Floor 4, Loggia 301A/B Hall 400A/B/C Hall 400A/B/C

*Additional registration, payment, and ticket required. **Additional registration and ticket required.

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Schedule-at-a-Glance Monday, July 16 07:00 – 08:00 07:00 – 17:30 07:00 – 18:00 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:00

09:30 – 17:00 09:30 – 17:30 10:30 – 12:00

Get Up! Get Educated! Interface of Biomaterials Elucidated Speaker Preparation Room Open CRS Registration Open CRS Opening Session Poster Session #1 (authors present) Exposition Open Young Scientist Committee/Mentor-Protégé Subcommittee Meeting CRS Central Open Poster Viewing Hours Scientific Sessions

• Bioactive Materials: Biomaterials

• Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization

• C&DP: Fragrances and Flavors

• Veterinary: Protein and Peptide Therapeutics for Animal Patients • Mini-Symposium: Active Targeting vs. Passive Targeting

11:30 – 13:30 Mentor-Protégé Meet and Greet 12:00 – 13:30 Exposition Open 13:30 – 14:45 Plenary Session: Donald A. Tomalia 14:30 – 16:30 2013 Exhibit Selection, Group B 15:00 – 16:00 Finance Committee Meeting 15:00 – 16:30 Scientific Sessions

• Bioactive Materials: Nanomedicines

• Bioactive Materials: Oral Controlled Release

• Bioactive Materials/Veterinary: Protein and Vaccine Delivery

• C&DP: Hydrogel Delivery Systems in Consumer Products

• Mini-Symposium: Recombinant Polymers— Macromolecules from Microbes 16:30 – 17:30 Poster Viewing and Exposition Happy Hour 17:30 – 18:30 Marketing Committee Meeting 17:30 – 18:30 Preclinical Sciences & Animal Health Get-Together** 21:00 – 22:30 Young Scientist Networking Evening*

205A/B 201A/B Floor 4, Main Hall 303A/B Hall 400A/B/C Hall 400A/B/C 304B Floor 4, Loggia Hall 400A/B/C 303A/B 301A/B 202 205A/B 302A/B 204A/B Hall 400A/B/C 303A/B TBD 304B 303A/B 301A/B 205A/B 202 302A/B Hall 400A/B/C 304B Hilton Québec, Les Plaines Room L’Astral Restaurant, Loews Hôtel Le Concorde

*Additional registration, payment, and ticket required. **Additional registration and ticket required.

Looking for the Abstracts?

Annual Meeting attendees have three convenient ways to access the abstracts.

1. Search and print abstracts for both podium presentations and posters at the Abstract Printing Station located near CRS Central.

2. Explore abstracts on your mobile device through the CRS 2012 mobile app.

3. Locate abstracts on the CRS annual meeting website by logging in with your username and password.

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Schedule-at-a-Glance Tuesday, July 17 07:00 – 08:00

07:00 – 08:00 07:00 – 16:00 07:00 – 17:30 07:00 – 17:30 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:30 09:30 – 15:30 10:30 – 12:00

12:00 – 13:30 12:00 – 13:30 12:00 – 14:00 12:00 – 16:00 13:30 – 15:00

15:00 – 16:00 16:00 – 17:00 16:00 – 17:00 16:00 – 17:30 16:00 – 17:30

16:00 – 18:00 18:30 – 22:00

Get Up! Get Educated! How to Get Published in JCR— 205A/B Editor’s and Publisher’s Views DDTR Editorial Board Meeting 304B Poster Viewing Hours Hall 400A/B/C CRS Registration Open Floor 4, Main Hall Speaker Preparation Room Open 201A/B Plenary Session: Molly Shoichet 303A/B Poster Session #2 (authors present) Hall 400A/B/C Exposition Open Hall 400A/B/C Chapter Committee Meeting 203 CRS Central Open Floor 4, Loggia Scientific Sessions • Bioactive Materials: Intracellular Processes 205A/B • Bioactive Materials: DNA and RNAi Delivery 301A/B • Bioactive Materials: Drug Delivery to the Brain 303A/B • C&DP: Consumer and Industrial Applications of 202 Nanoparticle Technology • Mini-Symposium: Morphologies and Cell Responses 302A/B Women in Science Luncheon* Hilton Québec, Beauport Room C&DP Division Luncheon* Hilton Québec, Ste. Foy/Portneuf JCR Editorial Board Meeting Hilton Québec, Courville/Montmorency Exposition Open Hall 400A/B/C Scientific Sessions: • Bioactive Materials: Inorganic Nanosystems 205A/B • Bioactive Materials: Oncology and Tumor Targeting 301A/B • Bioactive Materials: Transdermal Drug Delivery 303A/B • C&DP: Nutraceuticals and Functional Foods 202 • Mini-Symposium: Smart Textiles 302A/B Poster Session #3 (authors present) Hall 400A/B/C C&DP Committee Meeting 203 Poster Take-Down Hall 400A/B/C Emerging Issues and Trends Advisory Committee Meeting 304B Roundtables and Focus Groups • Nanomedicine 302A/B • Ocular Drug Delivery 301A/B • Oral Drug Delivery 303A/B Exhibit Take-Down Hall 400A/B/C CRS President’s Banquet* Hilton Québec Ballroom

Wednesday, July 18 07:00 – 08:00 07:30 – 12:00 08:00 – 11:30 08:00 – 09:30

09:45 – 11:00 12:00 – 16:00

Books Committee Meeting CRS Registration Open CRS Central Open Scientific Sessions • Bioactive Materials: Stem Cell and Regenerative Medicines • Bioactive Materials: Theranostics and Cancer Nanotechnologies • Bioactive Materials: Translational Nanomedicine • Bioactive Materials/C&DP: Nanofibers/Nanoparticles • Mini-Symposium: New Chemistries—Click It, Fit It, Test It Plenary Session: Vladimir P. Torchilin Educational Workshop: Considerations for Future Regulatory Submissions of Transdermal Products*

304B Floor 4, Main Hall Floor 4, Loggia 303A/B 301A/B 205A/B 202 302A/B 303A/B 205A/B

*Additional registration, payment, and ticket required. **Additional registration and ticket required.

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Daily Schedule Saturday, July 14

Saturday

07:00 – 15:00 CRS Registration Open 07:00 – 17:00 Speaker Preparation Room Open 08:00 – 12:00 Educational Workshop: Formulation and Process

Considerations in the Development/Scale Up of Osmotic

Dosage Forms* 08:00 – 17:00 Exhibit Set-Up 08:00 – 17:00 Educational Workshop: Critical Appraisal of EPR

Effect and Intratumoral Distribution of Nanomedicine* 08:00 – 17:00 Young Scientist Workshop #1: Mucosal Drug and Gene

Delivery: Barriers and Opportunities 12:00 – 14:00 Leadership Forum 13:00 – 17:00 Educational Workshop: Setting Release Specifications for In Vitro Testing of Controlled Release Dosage Forms*

Floor 4, Main Hall 201A/B 206A Hall 400A/B/C 205A/B 302A/B Hilton Québec Ste. Foy/Portneuf 208A/B

Saturday Program Highlights Educational Workshops*

Young Scientist Workshop #I

Critical Appraisal of EPR Effect and Intratumoral Distribution of Nanomedicine

Mucosal Drug and Gene Delivery: Barriers and Opportunities

08:00 – 17:00 • 205A/B

08:00 – 17:00 • 302A/B

Formulation and Process Considerations in the Development/Scale Up of Osmotic Dosage Forms

Speakers: Padma Devarajan, Institute of Chemical Technology, India; Camilla Foged, University of Copenhagen, Denmark; Justin Hanes, Johns Hopkins University, U.S.A.; Edith Mathiowitz, Brown University, U.S.A.; Michael Rathbone, International Medical University, Malaysia; Joshua Reineke, Wayne State University, U.S.A.; Kim Woodrow, University of Washington, U.S.A.; and Jaime Yanez, Alcon, U.S.A.

Chaired by: Khaled Gerish, University of Otago, New Zealand, and You Han Bae, University of Utah, U.S.A.

08:00 – 12:00 • 206A

Chaired by: Don Barbieri, Patheon, U.S.A., and Karen Coppens, Dow Wolff Cellulosics, U.S.A. Setting Release Specifications for In Vitro Testing of Controlled Release Dosage Forms 13:00 – 17:00 • 208A/B

Chaired by: Bob Stagner, Patheon, U.S.A.

*Additional registration, payment, and ticket required.

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Chairs: Emmanuel Ho, University of Manitoba, Canada; Olivia Merkel, Wayne State University, U.S.A.; and Joshua Reineke, Wayne State University, U.S.A.

This is a workshop not to be missed by young scientists. Local drug and gene delivery offers various advantages; however, many local administration routes involve delivery to the dynamic and complex mucosa. The mucosal layer and underlying membrane are involved in the absorption and secretion of molecules and are important targets for vaccine development and treatment of diseases. In this workshop, all relevant barriers will be discussed, and successful approaches for various administration routes will be presented.

Delivery Science and Technology is a Beautiful Thing!

The new technologies, the microscopic views, the unique findings— everything is conveyed better in pictures.

If you have an enviable photo or full collection, CRS would love to feature it in a prominent position on the CRS homepage. A new photo is featured on the CRS homepage every few weeks, with a link to a page with a full description of the photo along with your photo credit.

By sharing your images, you are explaining to delivery scientists worldwide what you are doing in your area of delivery science and technology and demonstrating just how breathtaking our science can be.

Share Your Images Stop by CRS Central or visit www.controlledreleasesociety.org/publications/imageresources/Pages/Contribute.aspx The Intellicap (schematic) courtesy of Jeff Shimizu. Corglaes courtesy of Jason King.

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Daily Schedule Sunday, July 15 Speaker Preparation Room Open CRS Registration Open Young Scientist Workshop #2: Professional and Self Development for Young Scientists and Protégés—Time Management Exhibit and Poster Set-Up Releasing Technology Workshop: Gattefossé SAS Releasing Technology Workshop: SOTAX Corporation Releasing Technology Workshop: Team Consulting Ltd. Releasing Technology Workshop: Agilent Technologies Releasing Technology Workshop: Catalent Pharma Solutions Releasing Technology Workshop: EMD Millipore Releasing Technology Workshop: OctoPlus and Mirna Therapeutics Releasing Technology Workshop: Ashland Releasing Technology Workshop: Grünenthal GmbH Releasing Technology Workshop: MedinCell SA 2013 Exhibit Selection, Group A First Timers’ Meeting Young Scientist Roundtable: Entrepreneurship: A Journey from Conception to Commercialization Educational Workshop #5: Preserving and Enhancing Vision via Ophthalmic Drug Delivery* Soapbox Sessions CRS Central Open Industry Roundtable: Game-Changing Innovation Exposition Grand Opening and Welcome Reception Poster Viewing Hours

201A/B Floor 4, Main Hall 302A/B Hall 400A/B/C 202 205C 303A 303A 202 205C 303B 205C 202 303A 203 204A/B 302A/B 205A/B 301A/B Floor 4, Loggia 301A/B Hall 400A/B/C Hall 400A/B/C

*Additional registration, payment, and ticket required.

CRS—Your Delivery Science and Technology Library

CRS members % save on all purchases.

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Watch for more titles in the Advances in Delivery Science and Technology series coming soon!

Visit CRS Central and Booth #126 for More Information.

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#8638probkfill-5/2012

Sunday

07:00 – 17:30 07:30 – 18:00 08:00 – 12:00

08:00 – 14:00 09:00 – 10:00 09:00 – 10:00 09:00 – 10:00 10:15 – 11:15 10:15 – 11:15 10:15 – 11:15 10:30 – 12:30 11:30 – 12:30 11:30 – 12:30 11:30 – 12:30 10:00 – 12:00 11:30 – 12:30 12:30 – 14:00

12:30 – 17:30

13:00 – 15:10 13:00 – 17:30 15:30 – 17:30 17:30 – 19:30 17:30 – 19:30

Sunday Program Highlights CRS Innovation Sunday

Industry Roundtable: Game-Changing Innovation

Cosponsored by Pfizer

15:30 – 17:30 • 301A/B

Releasing Technology Workshops These complimentary workshops are open to all registered attendees, offering in-depth coverage of controlled release technologies and services, hosted by the following companies: 09:00 – 10:00 09:00 – 10:00 09:00 – 10:00 10:15 – 11:15 10:15 – 11:15 10:15 – 11:15 10:30 – 12:30 11:30 – 12:30 11:30 – 12:30 11:30 – 12:30

Gattefossé SAS SOTAX Corporation Team Consulting Ltd. Agilent Technologies Catalent Pharma Solutions EMD Millipore OctoPlus and Mirna Therapeutics Ashland Grünenthal GmbH MedinCell SA

202 205C 303A 303A 202 205C 303B 205C 202 303A

See pages 17 and 18 for details.

Soapbox Sessions Cosponsored by Catalent Pharma Solutions Cochairs: Eyal S. Ron, MADASH LLC, U.S.A.; and Michael J. Valazza, Catalent Pharma Solutions 13:00 – 15:10 • 301A/B

Identify new opportunities and potential collaborations in these fast-paced presentations where technology-driven, emerging, and established businesses present their products, services, and technologies. Session breaks allow time to network with presenters at their designated tables. See page 21 for scheduled presentations of these participating companies.

Agilent Technologies Andros Pharmaceuticals Co. Ltd. Critical Pharmaceuticals EMD Millipore, a division of Merck KGaA Entrega, Inc., Enlight Biosciences Enzon Pharmaceuticals, Inc. Fresenius Kabi Deutschland GmbH Giltech Glatfelter Grünenthal GmbH Harvard Medical School/Massachusetts Eye and Ear Infirmary, Ophthalmology Medimetrics Nanocopoeia, Inc. Novozymes Biopharma Phosphorex, Inc. Precision NanoSystems Starpharma Pty. Ltd. Verdex Technologies, Inc.

Moderator: Baruch Harris, Vice President, Strategy & Operations, Enlight Biosciences, U.S.A. Speakers: Julia Rashba-Step, Sr. Director, Novel Delivery Technologies, BioTx Pharmaceutical Sciences, Pfizer, U.S.A.; and Ronald L. Smith, Executive Director, Pharmaceutical Sciences, Product Value Enhancement, Merck Research Laboratories, Merck & Co., Inc., U.S.A. From Incremental to Exponential Innovation: Game Changing!

If most innovation is incremental and game changers spark exponential innovation, how do you find a game changer?

How do you identify one, or a dozen, game changers for your organization? Who has the skills to put the new rules into play?

How do you recognize, integrate, and fully benefit from a game changer arriving from an entirely different discipline? Through panels, presentations, and audience participation, gain insight for game-changing strategies, nontraditional partners, and relationships.

Game Changer Definition: A visionary. A person or idea that transforms the accepted rules, processes, strategies, and management of business functions.

Exposition Grand Opening and Welcome Reception 17:30 – 19:30 • Hall 400 A/B/C

A day dedicated to innovation ends in the Exposition Hall with the Grand Opening of the Exposition and Welcome Reception.

Join more than 100 exhibiting companies as they showcase their products, services, and still-to-be-developed innovations.

Discuss your needs one-on-one with exhibitors while enjoying delicious food and beverages.

15

Sunday

Build your networks for success at the third annual CRS Innovation Sunday! Designed to connect you with people, research, companies, and novel technologies that address challenges in delivery, come to Sunday’s interactive program open to asking questions and finding answers.

Sunday Program Highlights Educational Workshop

First Timers’ Meeting

Preserving and Enhancing Vision via Ophthalmic Drug Delivery*

11:30 – 12:30 • 204A/B

12:30 – 17:30 • 205A/B

Chaired by: Charles Doillon, Laval University, Canada, and Todd Hoare, McMaster University, Canada

If this is your first CRS Annual Meeting & Exposition, or even if you are a seasoned veteran, learn how to get the most from the annual meeting program by attending this welcome and question-and-answer session presented by the CRS Board of Directors.

Sunday

Young Scientist Workshop #2:

Exposition Grand Opening and Welcome Reception

Professional and Self Development for Young Scientists and Protégés—Time Management

17:30 – 19:30 • Hall 400A/B/C

Cosponsored by Vision Processing 08:00 – 12:00 • 302A/B

Chaired by: Padma V. Devarajan, Institute of Chemical Technology, India; and Teresa Virgallito, Microtek Laboratories, Inc., U.S.A. Trainers: Buket Aksu, Santa Farma Ilac San AS, Turkey; and Teresa Virgallito, Microtek Labs Inc., U.S.A. Managing time effectively is extremely important for young scientists to enable them to cope with busy schedules, meeting deadlines, and so on. This workshop will cover time management skills that are needed to plan and execute projects and demonstrate how to complete project work successfully within a designated timeframe. Emphasis will be on the techniques of time management and utilization of these skills to function effectively, even under intense pressure.

By applying the time-management tips and skills presented in this workshop, young scientists will learn to optimize their efforts to ensure maximum benefits. More importantly, they will understand and appreciate the value of time, with a much clearer understanding of how to use time to its greatest effect.

Young Scientist Roundtable Entrepreneurship: A Journey from Conception to Commercialization 12:30 – 14:00 • 302A/B

Chairs/Moderators: David Chen, Pfizer, U.S.A.; and Sara Yazdi, Millennium: The Takeda Oncology Company, U.S.A. Speakers: Debra Bingham, Valeo Partners, U.S.A.; Justin Hanes, Johns Hopkins University, U.S.A.; Hardik Shah, Alkermes, Ireland; and Clive Wilson, University of Strathclyde, United Kingdom This roundtable discussion brings together leaders in drug delivery to share their personal stories of the journey from conception to commercialization of an innovation and to discuss how young scientists can recognize and seize the opportunities for starting a drug delivery business venture.

*Additional registration, payment, and ticket required.

16

A day dedicated to innovation ends in the Exposition Hall with the Grand Opening of the Exposition and Welcome Reception.

Join more than 100 exhibiting companies as they showcase their products, services, and still-to-be-developed innovations.

Discuss your needs one-on-one with exhibitors while enjoying delicious food and beverages.

EMPLOYERS

Find the Right Employee in 3 Steps CRS Job Center 1. Post Your Job Description Share your job description and qualifications with skilled candidates

2. Search for Candidates Look for your new employee in our online bank of resumes

3. Contact Your Perfect Choice Once you have identified your ideal

applicant, contact them via the Job Center

Finding qualified candidates in the area of delivery science and technology has never been more targeted. Post your job today!

Special Meeting Savings Post Your Job Through August 3 and Save 20%! www.controlledreleasesociety.org/careers

Releasing Technology Workshops These complimentary workshops are open to all registered attendees, offering in-depth coverage of controlled release technologies and services, hosted by the following companies:

09:00 – 10:00 Workshops

10:15 – 11:15 Workshops

Drug Release Testing for Combination Products Lipid Excipients: Born to Be Extruded Room 202

Presenter: Delphine Marchaud and Guest Speakers

Product life-cycle management and an overcrowded patent arena are driving interest in specialty excipients and processes.

Lipid excipients have interesting functionality in oral controlled release systems and in drug solubility/bioavailability enhancement. This workshop will explain their utility in hotmelt extrusion to modulate drug dissolution, solubility, and improve processability.

Release Rate Testing of Injectable Formulations Using USP Apparatus 4—Flow-Through Dissolution Room 205C

Presenter: Samir Haddouchi, Director, SPS Pharma Services

This workshop will discuss the successful development of a dissolution method to demonstrate the release rate from an injectable formulation using USP Apparatus 4. Injectable formulations can be used for the long-term administration of fragile molecules such as proteins. A case study will be presented.

Room 303A

Presenter: Bryan Crist, Scientific Affairs Manager

As the pharmaceutical market continues to expand for low-dose combination products, analytical challenges for dependable drug release testing must keep pace. This presentation will highlight several novel products and how researchers have overcome hurdles to test medicated contact lens, drug eluting stents and balloons, catheters, vaginal rings, and implants.

Recent Advances in Oral Granules and Bi-Layer Tablet Technologies, Solubility Enhancement Solutions, and Oral Disintegrating Tablet Applications Room 202

Presenter: Michael J. Valazza, Vice President, Global Modified Release Technologies This workshop will focus on new advancements in modified controlled release technologies, including novel OSDrC® OPTIDOSE™ optimized dose delivery technology, solubility enhancement with OptiMelt™ hot-melt extrusion, and case studies of Zydis® fast-dissolve applications.

Parenteral Delivery: The Emerging Device Landscape and Potential

Drug Delivery Compounds for Parenteral Applications

Room 303A

Room 205C

Presenter: Andy Fry, Founder

Growth in biologics, reliant upon parenteral delivery, has stimulated demand for better delivery devices for a range of applications, formulations, and users. Regulators, patients, and clinicians demand devices with higher standards of safety and usability. This workshop explores these and other drivers, their interrelationships, and potential scenarios for the future.

Presenters: Mr. Robert Kriftner, Manager Drug Delivery Compounds, Global Marketing; and Dr. Adela Kalivoda, Technical Marketing Manager Delivery Systems

In its center of excellence for the development of specialty-grade lipids and activated PEGs for protein conjugation, EMD Millipore manufactures compounds in small and large quantities under cGMP in order to cover the growing demands in parenterally administered medicinal products and PEG-based hydrogels for medical devices related to surgery.

17

10:30 – 12:30 Workshop

11:30 – 12:30 Workshops

Liposomes: From Manufacturing to (Pre)Clinical Trials

Newly Launched Intermediate Hypromellose (HPMC) Grades

Industrial Application: Selection Process of Optimal Systemic Delivery Technology for Double-Stranded miRNA Mimics

Room 205C

Room 303B

Presenters: Ms. Marie-Andree Yessine, Scientist, OctoPlus; and Mr. Neil Leatherbury, Associate Director of Pharmaceutical Development, Mirna Therapeutics OctoPlus will share the challenges associated with scale up and manufacturing of liposomes, emphasizing lipid/siRNA delivery systems, followed by industrial applications of a liposome formulation. A systematic review and assessment of different systemic delivery technologies for Mirna’s proprietary miRNA mimic will be presented. Factors included, amongst others, efficiency of delivery, immune-stimulatory effects, PK and PD parameters, and overall safety and tolerability in an orthotopic mouse model of aggressive liver cancer. The current product development plan for MRX34, the company’s lead therapeutic candidate in cancer, will be highlighted, including next steps and timeline for entering into first clinical trial.

Presenter: Divya Tewari, Manager

Newly created intermediate molecular weight grades of HPMC provide solutions for controlled release applications with difficult-to-solubilize drugs that need a specific release profile.

The new grades provide predictable and robust profiles even under stressed conditions where other excipients and blends fail.

Innovative Tamper Resistant Formulation (TRF) Technology—Protecting Intended Drug Action Room 202

Presenter: Prof. Dr. Johannes Bartholomaeus

Find an update on the pandemic problem of prescription drug abuse in the United States. Learn about how opioid prescription drugs are abused. How can the hurdle to these routes of abuse be raised? INTAC™—innovative tamper resistant formulation (TRF) technology—protecting intended drug action.

MedinGel: A Controlled Release Delivery Platform for Global Markets Room 303A

Presenter: Dr. Georges Gaudriault, CSO

MedinCell’s controlled release delivery platform offers wideranging durations—from several days up to one year—for many small molecules and biologics, and it requires no API modification. Current commercial partnerships aim to address delivery hurdles across arthritis, oncology, contraception, and HIV, and our low-cost manufacturing enables partners to target fast-growing emerging markets.

18

CRS: By Members, For Members Stop by CRS Central this year to see what the CRS membership has accomplished! With the success of new books, journals, webcasts, committees, and divisions, our CRS members truly are the “stars.” Take your time and sign up for the job board or become a part of the new LATTE database, two important member initiatives.

Not a member? Or want to know how to get involved?

You can do that there too!

CRS Central • Floor 4, Loggia Sunday 13:00 – 17:30 09:30 – 17:00 Monday Tuesday 09:30 – 15:30 Wednesday 08:00 – 11:30

Stronger!

Innovative formulation technology protecting intended drug action

The Benefits of INTAC™ Confers outstanding crush resistance Raises hurdles against prescription drug abuse

Tailor-made release properties Established at commercial manufacturing scale Featured in FDA-approved products

Dramatization!

Patient-friendly formulation; no aversive additives needed

Please see us in booth

#128

and join our workshop

For more information: info@intac.grunenthal.com Grünenthal, 52099 Aachen, Germany

DR_RZ_2150_GRUEN_0017_AZ_Intac 1

18.05.12 15:40

Soapbox Sessions Cosponsored by Catalent Pharma Solutions 13:00 – 15:10 • 301A/B

Comoderators: Eyal S. Ron, MADASH LLC, U.S.A.; and Michael J. Valazza, Catalent Pharma Solutions CRS Soapbox Sessions introduce the latest, most novel technologies, products, and services for delivery science. Identify new ideas and potential collaborations in these fast-paced presentations as well as during the one-on-one networking breaks following the presentations.

13:00 – 13:10

Introduction and Welcome Eyal S. Ron, MADASH LLC, and Michael J. Valazza, Catalent Pharma Solutions

14:05 – 14:10

13:10 – 13:15

Critical Technologies for Drug Delivery Clare Upton, Critical Pharmaceuticals

HESylation®—An Innovative Drug Delivery Technology for Proteins and Small Molecule Drugs Peter Vorstheim, Fresenius Kabi Deutschland GmbH

13:15 – 13:20

New Manufacturing of Microcapsules Lars Petersen, Glatfelter

14:15 – 14:20

Mechanical Qualification for Dissolution Apparatus: Saving Time and Money Bryan Crist, Agilent Technologies

14:10 – 14:15

13:20 – 13:25

IntelliCap—Electronic Capsule for In Vivo Studies Jeff Shimizu, Medimetrics

ElectroNanospray™ a One-Step Process for Producing Therapeutic Nanoparticles for Drug Delivery and Bioactive Medical Device Coatings Jane Nichols, Nanocopoeia, Inc.

13:25 – 13:30

A Novel Lipid-Based Carrier for the Topical Delivery of Local Anesthetics Ae-June Wang, Andros Pharmaceuticals Co. Ltd.

14:20 – 14:30

Networking Break

Session I

13:30 – 13:35

Intac™—An Innovative Formulation Technology Protecting Intended Drug Action Johannes Bartholomaeus, Grünenthal GmbH

Controlled, Sustained Release of Metal Ions from Soluble Phosphate Polymers Jason King, Giltech

13:40 – 13:50

Networking Break

13:35 – 13:40

13:55 – 14:00

14:00 – 14:05

14:30 – 14:35

14:35 – 14:40

14:40 – 14:45

14:45 – 14:50

Session II 13:50 – 13:55

Session III

New Inorganic Carrier for Solubility Enhancement Leonhard Ohrem, EMD-Millipore, a division of Merck KGaA Improving the Efficacy of Cytotoxics Through Dendrimer Technology Pauline Stanislawski, Starpharma Pty. Ltd. Contact Lens Drug Delivery Joseph Ciolino, Harvard Medical School/ Massachusetts Eye and Ear Infirmary, Ophthalmology

14:50 – 14:55

Engineering Albumin to Tailor Serum Half-Life and Improve Drug Efficacy Hans Ole Klingenberg, Novozymes Biopharma Drug Delivery—From Proof of Concept to Clinical Trials Bin Wu, Phosphorex, Inc. Microfluidic-Mediated Manufacture of “Limit-Size” Lipid Nanoparticles (lsLNP) for Drug Delivery Applications Euan Ramsay, Precision NanoSystems Bioresorbable Nanofibrous Materials with Controlled Delivery Functionalizations Larry R. Marshall, Verdex Technologies, Inc. Simple Oral Delivery of Poorly Bioavailable Molecules Baruch Harris, Entrega, Inc., Enlight Biosciences

Controlled Release of Proteins Through Releasable PEGylation Hong Zhao, Enzon Pharmaceuticals, Inc.

15:00 – 15:10

Networking Break

14:55 – 15:00

21

Daily Schedule Monday, July 16 Get Up! Get Educated! Interface of Biomaterials Elucidated Speaker Preparation Room Open CRS Registration Open CRS Opening Session Poster Session #1 (authors present) Exposition Open (redeem café beverage ticket) Young Scientist Committee/Mentor-Protégé Subcommittee Meeting CRS Central Open Poster Viewing Hours Scientific Sessions

• Bioactive Materials: Biomaterials

• Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization

• C&DP: Fragrances and Flavors

• Veterinary: Protein and Peptide Therapeutics for Animal Patients

Cosponsored by Merial

• Mini-Symposium: Active Targeting vs. Passive Targeting 11:30 – 13:30 Mentor-Protégé Meet and Greet Exposition Open (lunch available for purchase) 12:00 – 13:30 13:30 – 14:45 Plenary Session: Donald A. Tomalia 2013 Exhibit Selection, Group B 14:30 – 16:30 15:00 – 16:00 Finance Committee Meeting Scientific Sessions 15:00 – 16:30

• Bioactive Materials: Nanomedicines

• Bioactive Materials: Oral Controlled Release

• Bioactive Materials/Veterinary: Protein and Vaccine Delivery • C&DP: Hydrogel Delivery Systems in Consumer Products

• Mini-Symposium: Recombinant Polymers— Macromolecules

from Microbes 16:30 – 17:30 Poster Viewing and Exposition Happy Hour 17:30 – 18:30 Marketing Committee Meeting Preclinical Sciences & Animal Health Get-Together 17:30 – 18:30

21:00 – 22:30 Young Scientist Networking Evening*

205A/B 201A/B Floor 4, Main Hall 303A/B Hall 400A/B/C Hall 400A/B/C 304B Floor 4, Loggia Hall 400A/B/C 303A/B 301A/B

Monday

07:00 – 08:00 07:00 – 17:30 07:00 – 18:00 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:00

09:30 – 17:00 09:30 – 17:30 10:30 – 12:00

202 205A/B 302A/B 204A/B Hall 400A/B/C 303A/B 203 304B 303A/B 301A/B 205A/B 202 302A/B Hall 400A/B/C 304B Hilton Québec, Les Plaines Room L’Astral Restaurant, Loews Hôtel Le Concorde

*Additional registration, payment, and ticket required.

23

Monday Program Highlights Get Up! Get Educated!

New Format for 2012—Poster Session

Interface of Biomaterials Elucidated

Cosponsored by AstraZeneca

07:00 – 08:00 • 205A/B

Chair: Joshua Reineke, Wayne State University, U.S.A. Speaker: Vincent Rotello, University of Massachusetts Amherst, U.S.A.

Monday

Are protein adsorption, cellular adhesions, immune responses, or inflammatory reactions fogging the surface of your biomaterials? Wake up to this session illuminating the interactions of biomaterial surfaces with the complex biological milieu. This session will cover interactions and forces at the interface of materials with proteins, cellular membranes, organelles, and DNA. Learn how these interactions can determine the fate of biomaterials and of novel approaches to circumvent or advantageously utilize these interactions.

Opening Session

All scientific posters will be on display throughout the meeting.

Poster authors have been designated into one of three sessions.

On Monday, authors will be present at posters during the time specified below. Please use the information in the back of the program book to determine which poster authors will be present during Monday’s session. Poster information can also be found in the mobile app, CRS website, and abstract printing station.

Poster Session #1: 09:30 – 10:30

Redeem your ticket for a complimentary beverage from the Café.

Mentor-Protégé Meet and Greet Chairs: Padma V. Devarajan, Institute of Chemical Technology, India; and Mike Rathbone, International Medical University, Malaysia.

08:00 – 09:30 • 303A/B

11:30 – 13:30 • 204A/B

The Opening Session will feature a welcome by President Martyn Davies, who will provide a brief update on what your association is doing to further delivery science and technology during the annual business meeting portion of the meeting. This session will also be a time to honor the 2012 CRS Distinguished Service awardee and Fellows awardees, along with the CRS T. Nagai Postdoctoral Research Achievement Award and talks from our Founders Award winner, Chezy Barenholz, and Young Investigator Award winner, Cory Berkland. Two new members of the College of Fellows will also be inducted.

Lunch will not be provided; however, attendees are invited to bring their own lunch. Lunch will be available for purchase in the exhibit hall.

This is a must-attend session for anyone enrolling in the 2011– 2012 CRS Young Scientist Mentor-Protégé Program. You will be introduced to your mentor and be given the opportunity to meet face-to-face to discuss how you are going to interact with your mentor over the next 12 months, what your career ambitions are, and what you want out of the program. Attend this meeting and gain your first CRS mentorship experience.

Plenary Speaker

Thirsty for Information?

Try LATTE—Linking Academic Technologies and Techniques to Everyone—a searchable database designed to help you identify experts in specific areas of CRS-related technologies and techniques.

CRS Members—You are invited to create your LATTE profile to offer your expertise to the membership and search LATTE to find the experts you are looking for.  Sign up in CRS Central or online at www.controlledreleasesociety.org/ community/Pages/LATTE.aspx

LATTE 24

Dendrimer-Based Nanomedicine—The Present and Future 13:30 – 14:45 • 303A/B

Moderator: Susan Cady, Merial Ltd., U.S.A.

Donald A. Tomalia, CEO/Founder, NanoSynthons, LLC, National Dendrimer and Nanotechnology Center, U.S.A.

Prior to the plenary, the 2012 Sung Wan Kim Postdoctoral Fellowship, will be given to Tram Dang, recent PhD graduate of Massachusetts Institute of Technology. Also, the 2011 fellowship awardee, Soo Hyeon Lee, will present research from her fellowship year at ETH Zurich.

Poster Viewing and Exposition Happy Hour 16:30 – 17:30 • Hall 400A/B/C

New for 2012! Relax after a day of sessions—meet with exhibitors, view the 600+ posters, and chat with colleagues.

Beverages available for purchase.

Cosponsored by Pfizer Animal Health

17:30 – 18:30 • Hilton Québec, Les Plaines Room

Organizers: Marilyn Martinez, FDA Center for Vet Medicine, U.S.A.; Arlene McDowell, University of Otago, New Zealand; Mike Rathbone, International Medical University, Malaysia; and Thierry Vandamme, University of Strasbourg, France The new Preclinical Sciences & Animal Health Division has been established to further develop and expand the Veterinary Division. Its goal is to foster the opportunity for collaboration between CRS members interested in animal and human health.

If you are interested in preclinical sciences or the science and technology of animal health products, then attend the GetTogether, mingle with like-minded people, make new contacts, and discover new opportunities for multifaceted collaborations with fellow CRS members.

The Get-Together promises to be a memorable occasion. An overview of the new division will be given. The highlight of the night will be a Pub Quiz on animal health and controlled release, after which a committee will be formed to run the new division.

Volunteer to be a part of this committee and take part in CRS history!

There is no cost to attend the Preclinical Sciences & Animal Health Get-Together, although preregistration is required.

Young Scientist Networking Evening Organizers: David Chen, Pfizer, U.S.A.; Sarah Eccleston, Encap Drug Delivery, Scotland; Amrita Mehta, Pfizer, U.S.A.; and Joshua Reineke, Wayne State University, U.S.A. 21:00 – 22:30 • L’Astral Restaurant, Loews Hôtel Le Concorde Sponsored by Upsher-Smith Labs

Enjoy an evening of interacting with colleagues when you attend the Young Scientist networking evening and dessert reception at the only revolving rooftop restaurant in Québec City, L’Astral Restaurant at Loews Hôtel Le Concorde. Enjoy French Canadian desserts, crepes, coffee, and tea. One drink ticket is included when you register for this event. Cash bar available.

Loews will be offering a dinner special for those who wish to dine at L’Astral Restaurant before the networking event.

Preregistration, payment, and ticket required.

CRS Headquarters & Staff 3340 Pilot Knob Road, St. Paul, MN 55121 U.S.A. Telephone +1.651.454.7250 • Facsimile +1.651.454.0766 www.controlledreleasesociety.org

Administration Steven C. Nelson, Executive Vice President +1.651.994.3832 snelson@scisoc.org Amy Hope, Vice President of Operations +1.651.994.3827 ahope@scisoc.org Barbara Mock, Vice President of Finance +1.651.994.3829 bmock@scisoc.org Susan Kohn, Executive Director +1.651.994.3812 skohn@scisoc.org Megan Pagel, Program Manager +1.651.994.3854 mpagel@scisoc.org

Meetings Meeting Planning Leah Barna, Meeting Manager +1.651.994.3867 lbarna@scisoc.org

News Capsule Megan Pagel, Program Manager +1.651.994.3854 mpagel@scisoc.org Awards Linda Schmitt, Program Supervisor +1.651.994.3828 lschmitt@scisoc.org Chapters Megan Pagel, Chapter Coordinator +1.651.994.3854 mpagel@scisoc.org Foundation Debby Woodard, Director of Development +1.651.994.3817 dwoodard@scisoc.org Marketing Karen Deuschle, Marketing Manager +1.651.994.3804 kdeuschle@scisoc.org

Publications

Linda Schmitt, Program Supervisor +1.651.994.3828 lschmitt@scisoc.org

CRS Website and Webcasts Brian Simdars, Webmaster +1.651.994.3849 bsimdars@scisoc.org

Registration, Abstracts Sue Casey, Meeting Coordinator +1.651.994.3846 scasey@scisoc.org

Journal Liaison Greg Grahek, Publications Director +1.651.994.3841 ggrahek@scisoc.org

Exhibits, Sponsorship Debby Woodard, Director of Development +1.651.994.3817 dwoodard@scisoc.org

CRS Newsletter Carol Duling, Technical Editor +1.651.994.3869 cduling@scisoc.org

Membership and Communications

Advertising Sales Debby Woodard, Director of Development +1.651.994.3817 dwoodard@scisoc.org

Member Service Cheryl Kruchten, Member Relations Specialist +1.651.994.3801 ckruchten@scisoc.org

Monday

Preclinical Sciences & Animal Health Get-Together

25

Podium • Monday Morning 301A/B

303A/B

Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization

Bioactive Materials: Biomaterials

J Meiners, R Walker

10:30

1

Invited Speaker: Imaging Techniques for the Characterisation of Advanced Delivery Systems and Biomedical Systems M Davies University of Nottingham, UNITED KINGDOM

A Chilkoti, P Ferruti

6

Invited Speaker: Self-assembled polysaccharide nanogels with chaperon function for protein delivery K Akiyoshi Kyoto University, JAPAN

202

C&DP: Fragrances and Flavors

J McKinney, C Ortiz

Monday

11 Invited Speaker: Microencapsulation Using Fluid Bed System and Prilling Techniques, concepts to realities, factors associated with process development L Lee, B Patel Vision Processing Technologies LLC, U.S.A.

10:45

122 Relating the influence of temperature 7 and humidity on the surface characteristics of a spray-dried polymeric matrix consisting of poly(lactic-co-glycolic acid) and polyvinylpyrrolidone to the thermal characteristics of these polymers J Meeus, D J Scurr, X Chen, V Ciarnelli, M C Davies, C J Roberts, G Van den Mooter KU Leuven, BELGIUM 3 Confocal Raman microscopy as a 8 novel approach for development and chemically resolved characterization of a drug permeation model B Kann, S Gantzsch, U F Schaefer, C Lehr, M Windbergs Saarland University, GERMANY

Curcumin-loaded triblock poly(212 Micromanipulation and Finite Element methyl-2-oxazoline-b-tétrahydrofuraneAnalysis to Determine the Mechanical b-2-methyl-2-oxazoline) copolymer Strength of Perfume Microcapsules restores a functional ∆F508-CFTR in R Mercadé-Prieto, R Allen, Z Zhang the plasma membrane of ∆F508-CFTR University of Birmingham, UNITED cells KINGDOM P Midoux, C Gonçalves, J Gomez, B Rasolonjatovo, T Le Gal, T Montier, P Lehn, C Pichon, P Guégan, H Cheradame CNRS UPR4301, FRANCE Control of Transcription Factors by Redox Nanoparticle for Novel Antitumor Nanotherapy Y Nagasaki, Y Ozaki, T Yoshitomi University of Tsukuba, JAPAN

13 Niosome as a carrier for oral delivery of Ginkgo biloba Extract Y Jin, L Teng, W Zhang, D Liu, J Wen School of Pharmacy, University of Auckland, NEW ZEALAND

11:30

4

The Studies of Newly Synthesized Polymer-Coated SPION in SpragueDawley Rats S Hwang, J Ahn, H Kang, J Park, W Cho, B Sun Yonsei University, KOREA

9

A guanidine-substituted polyamidoamine with outstanding antiviral activity against Herpes Simplex Virus, Papilloma Virus, Cytomegalovirus and probably other DNA viruses P Ferruti, D Lembo, M Donalisio, E Ranucci, A Manfredi, R Cavalli Università di Milano, ITALY

14 Thermoplastic Shaping for Pharmaceuticals: Coupling Hot Melt Extrusion with Injection Moulding B H Liepold, M Pauli Abbott GmbH & Co KG, GERMANY

11:45

5

An Electrospun Triple-Layered PCLPEVA-PCL Nanofibre Matrix Controlled Release Drug Delivery System N Alhusein, P De Bank, I S Blagbrough University of Bath, UNITED KINGDOM

134 Biodegradable hydrophilic SynBiosys Pro monospheres for long-term parenteral delivery of proteins C Hiemstra, M Staal, A Lathuile, G J Veldhuis, R Steendam InnoCore Pharmaceuticals, NETHERLANDS

15 Compritol® 888 ATO Lipid Matrices for Sustained Release Processed by HotMelt Extrusion D Douroumis, M Maniruzzaman, K Vithani, S Mostafa, Y Cuppok University of Greenwich, UNITED KINGDOM

End of Session

End of Session

11:00

11:15

12:00

26

End of Session

Podium 302A/B

205A/B

Mini Symposia: Active Targeting vs.

Passive Targeting

Veterinary: Protein and Peptide Therapeutics for Animal Patients

10:30

16 Invited Speaker: Active vs Passive Targeting of Drug Delivery Systems: Opportunities and Pitfalls T M Allen University of Alberta, CANADA

10:45

17 (10:50) Invited Speaker: Design and Biorecognition of Water-Soluble Macromolecular Therapeutics J Kopecek, J Yang Universityof Utah, U.S.A.

T Vandamme, M Rathbone

20 Invited Speaker: A Spoonful of Lipid Helps the Medicine go Down.LiporaleTm- an Oral Delivery System for Mucosal Vaccination F E Aldwell Immune Solutions Ltd, NEW ZEALAND

Monday

T Lammers, R Satchi-Fainaro

11:00

11:15

18 (11:10) Invited Speaker: Ligand21 Polymeric nanoparticles for delivery of directed therapy and molecular therapeutic compounds to wild imaging based on invivo phage display animals technology A McDowell, A P Kafka, J Z Chiu, B J R Pasqualini, W Arap McLeod, T Rades University of Texas MD Anderson Cancer University of Otago, NEW ZEALAND Center, U.S.A.

11:30

19 Invited Speaker: Drug Targeting to Tumors: To Actively Target, or Not to Actively Target?

G Storm, T Lammers, r schiffelers University of Utrecht, NETHERLANDS

11:45

12:00

22 Evaluating the Role of Dosage Size and Feeding on Gastric Retention in the Dog E L Mcconnell, A Lalloo, L Jin, R Elkes, H Wu Merck Sharpe & Dohme, UNITED KINGDOM

23 Quantitation of sustained release of triptorelin in beagle dog plasma by liquid chromatography-tandem mass spectrometry W Liu Yantai University, PRC PEOPLES REP OF CHINA

End of Session

End of Session

Cosponsored by Merial

27

Podium • Monday Afternoon 205A/B

303A/B

301A/B

Bioactive Materials/Veterinary: Protein and Vaccine Delivery

Bioactive Materials: Nanomedicines

Bioactive Materials: Oral Controlled Release

S Senel, A McDowell 15:00

C Allen, M Janat-Amsbury

D Brayden, F Dorkoosh

Monday

24 Invited Speaker: Uniform PLGA Microspheres Sustain NSAID Blood Levels With Zero-Order Kinetics Q Shang, X Wang, D W Dumbauld, M Singh, M Apley, B Kukanich, C Berkland University of Kansas and Orbis Biosciences, U.S.A.

29 Invited Speaker: Nanomedicines for Hyperactive Glia D Maysinger, A R McKinney McGill University, CANADA

34 Invited Speaker: Exploiting the Biology of Microbial Toxins for Protein Delivery R Mrsny University of Bath, UNITED KINGDOM

15:30

25 Engineered Pathogen-like Particle Subunit Vaccines Induce Robust, TH1Biased Immunity J Rosenthal, C Huang, A Doody, M DeLisa, S Mendez, D Putnam Cornell University, U.S.A.

30 Induction and Targeting of the Heat Shock Response in Prostate Cancer N Larson, A J Gormley, S Sadekar, R Robinson, A Ray, H Ghandehari University of Utah, U.S.A.

35 Oral disposition of G3.5 PAMAM dendrimer across mice intestinal epithelia and anticancer activity of its drug conjugate G Thiagarajan, A Ray, L Götz, D A Hubbard, S Sadekar, R A Price, H Ghandehari University of Utah, U.S.A.

15:45

26 PTHrP to Prevent Curve Progression in 31 NanostructuredThin Film Devices for a Novel Murine Model of Early Onset Delivery of Protein Therapeutics to the Scoliosis Eye M B Sullivan, A Esmaeel, M Kneifel, J A D A Bernards, K D Lance, N A Ciaccio, E Ouellet, N Saran, J E Henderson Chan, S Rofagha, R B Bhisitkul, T A McGill University, CANADA Desai University of California, San Francisco, U.S.A.

36 Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus y huang Sichuan University, PRC PEOPLES REP OF CHINA

16:00

27 CapsInjectTM: LBL Coating Technology for Controlled Delivery of Biologicals O Sakr, M Grabo, L Cuellar, G Borchard, R Mueller Freie University, GERMANY

32 Flt1 Peptide – Hyaluronic Acid Conjugate Micelle-Like NanoparticlesEncapsulating Genistein for the Treatment of Occular Neovascularization H Kim, J Choi, K Kim, J Yang, C Joo, S Hahn POSTECH, KOREA

37 Tailored Controlled Release by Printing of Drug Substances and Polymer Layers N Genina, D Fors, H Vakili, P Ihalainen, J Peltonen, N Sandler Abo Akademi University, FINLAND

16:15

28 Optimising transcutaneous immunization using microneedles and a colloidal carrier T Rattanapak, J Birchall, I Meglinski, T Rades, S Hook University of Otago, NEW ZEALAND

33 Recombinant Cell Penetrating Peptide Construct for Targeting Mildly Acidic pH L Fei, J L Zaro, W Shen University of Southern California, U.S.A.

38 Foam Hot Melt Extrusion of an Eudragit - Nifedipine Matrix Formulation using Supercritical CO2 T Listro, T Kane, A Adegoke, A Sarode, P Wang Foster Corporation, U.S.A.

16:30

End of Session

15:15

Cosponsored by Merial

28

End of Session

End of Session

Podium 202

302A/B

C&DP: Hydrogel Delivery Systems in Consumer Products

Mini Symposia: Recombinant Polymers - Macromolecules from Microbes

15:00

39 Invited Speaker: Contact Lenses for Delivery of Drugs to the Front and Back of the Eye H Sheardown, L Liu, L Subbaraman, G Guidi, A Hui McMaster University, CANADA

15:15

J Kopecek, C Wang 44 Invited Speaker: Protein Polymers and Their Design and Production for Medical Applications J Cappello University of Utah, U.S.A.

Monday

C Barbe, F Zeng

45 (15:20) Invited Speaker: Design of Elastin-like Polypeptides for Drug Delivery A Chilkoti Duke University, U.S.A.

15:30

40 Extended Release of DMPC from Silicone Hydrogel Contact Lenses W G Pitt, Y Zhao, K X Perez, D R Jack, J Lee, J L Nelson, J D Pruitt Brigham Young University, U.S.A.

15:45

41 Hydrogels with Enhanced Mechanical Properties Using End-Group Modified Pluronic F127 Blend System S Lee, J Kim, C Ahn Seoul National University, KOREA

46 (15:40) Invited Speaker: Silk Protein Stabilization and Delivery Systems D L Kaplan Tufts University, U.S.A.

16:00

42 Increased release time of diclofenac loaded into a cross-linked hyaluronic acid hydrogel M J Maltesen, M Larsen, F Longin, O Dall Novozymes Biopharma DK, DENMARK

47 Invited Speaker: Formulation Development for the Production of Efficient PEGylated-Targeted Nanoparticles A Hatefi, Z Karjoo, H McCarthy Rutgers University, U.S.A.

16:15

663 Effect of Probe Loading on Diffusive Behavior of Proteins in Polyacrylamide Gels S S Jena, S Khandai, R A Siegel National Institute of Technology, INDIA

16:30

End of Session

End of Session

29

Daily Schedule Tuesday, July 17 07:00 – 08:00

07:00 – 08:00 07:00 – 16:00 07:00 – 17:30 07:00 – 17:30 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:30 09:30 – 15:30 10:30 – 12:00

Tuesday

Get Up! Get Educated! How to Get Published in JCR—Editor’s and Publisher’s Views DDTR Editorial Board Meeting Poster Viewing Hours CRS Registration Open Speaker Preparation Room Open Plenary Session: Molly Shoichet Poster Session #2 (authors present) Exposition Open (redeem café beverage ticket) Chapter Committee Meeting CRS Central Open Scientific Sessions

• Bioactive Materials: DNA and RNAi Delivery

• Bioactive Materials: Drug Delivery to the Brain

• Bioactive Materials: Intracellular Processes

• C&DP: Consumer and Industrial Applications of Nanoparticle Technology Cosponsored by Coating Place Inc.

• Mini-Symposium: Morphologies and Cell Responses 12:00 – 13:30 Women in Science Luncheon* 12:00 – 13:30 C&DP Division Luncheon* 12:00 – 14:00 JCR Editorial Board Meeting 12:00 – 16:00 Exposition Open (lunch available for purchase) 13:30 – 15:00 Scientific Sessions:

• Bioactive Materials: Inorganic Nanosystems

• Bioactive Materials: Oncology and Tumor Targeting

• Bioactive Materials: Transdermal Drug Delivery Cosponsored by Mylan Technologies Inc.

• C&DP: Nutraceuticals and Functional Foods

• Mini-Symposium: Smart Textiles 15:00 – 16:00 Poster Session #3 (authors present, redeem café beverage ticket) 16:00 – 17:00 C&DP Committee Meeting Poster Take-Down 16:00 – 17:00 16:00 – 17:30 Emerging Issues and Trends Advisory Board Meeting 16:00 – 17:30 Roundtables and Focus Groups

• Nanomedicine

• Ocular Drug Delivery

• Oral Drug Delivery 16:00 – 18:00 Exhibit Take-Down 18:30 – 22:00 CRS President’s Banquet* *Additional registration, payment, and ticket required.

30

205A/B 304B Hall 400A/B/C Floor 4, Main Hall 201A/B 303A/B Hall 400A/B/C Hall 400A/B/C 203 Floor 4, Loggia 301A/B 303A/B 205A/B 202 302A/B Hilton Québec, Beauport Room Hilton Québec, Ste. Foy/Portneuf Hilton Québec, Courville/Montmorency Hall 400A/B/C 205A/B 301A/B 303A/B 202 302A/B Hall 400A/B/C 203 Hall 400A/B/C 304B 302A/B 301A/B 303A/B Hall 400A/B/C Hilton Québec, Ballroom

Tuesday Program Highlights Get Up! Get Educated!

Women in Science Luncheon

How to Get Published in JCR—Editor’s and Publisher’s Views

12:00 – 13:30 • Hilton Québec, Beauport Room

07:00 – 08:00 • 205A/B

Getting your work published in any highly ranked journal is a matter of presenting good research. Each manuscript needs to be tailor-made for a specific journal. In this workshop, the editor-in-chief and publisher of JCR will explain and give opportunity for discussion on the editorial decision-making process of JCR, including main reasons for acceptance and author–editor–reviewer communication. Get up! Get educated!

Get more successfully published!

Plenary Speaker Drug and Cell Delivery Strategies to the Central Nervous System 08:00 – 09:30 • 303A/B

Moderator: Mike Rathbone, International Medical University, Malaysia

Sponsored by Gattefosse

Moderator: Diane Burgess, University of Connecticut This popular event provides an insightful and informative presentation relevant to women in science and includes ample time networking time to meet with your fellow women scientists in Québec City. *Additional registration, payment, and ticket required.

C&DP Division Luncheon 12:00 – 13:30 • Hilton Québec, Ste. Foy/Portneuf

Sponsored by Coating Place, Fleet Laboratories, and Ronald T. Dodge Co. Join your fellow Consumer & Diversified Products Division members for this networking luncheon. Relax over lunch while discussing the day’s C&DP programming or connect with fellow attendees who specialize in this area. All attendees interested in C&DP are welcome to join. *Additional registration, payment, and ticket required.

Molly Shoichet, Professor of Chemical Engineering and Applied Chemistry, Chemistry and Biomaterials, and Biomedical Engineering, University of Toronto, Canada

Awards presented prior to the plenary will include CRS Jorge Heller Journal of Controlled Release Outstanding Paper Award to Christine Allen and David Jaffray of the University of Toronto, DDTR Outstanding Paper Award to Tamara Minko of Rutgers University, and CRS Outstanding Chapter Awards to the United Kingdom-Ireland Local Chapter and the Connecticut Student Chapter.

New Format for 2012—Poster Sessions Cosponsored by AstraZeneca

All scientific posters will be on display throughout the meeting.

Poster authors have been designated into one of three sessions.

On Tuesday, authors will be present at posters during the times specified below. Please use the information in the back of the program book to determine which posters have authors present during Tuesday’s sessions. Poster information can also be found in the mobile app, CRS website, and abstract printing stations.

Poster Session #2: 09:30 – 10:30 Poster Session #3: 15:00 – 16:00 Redeem your ticket for a complimentary beverage from the Café during these sessions.

continued on page 32

JOB SEEKERS

Find the Right Job in 3 Steps CRS Job Center 1. Post Your Resume Share your resume so employers in delivery science can find you

2. Search for Jobs Find your new position by searching through a bank of relevant niche jobs

3. Set Up Job Alerts Receive openings matching your specific

criteria—sent right to your e-mail

Finding a job in the area of delivery science and technology has never been easier. Start by posting your resume today!

Stop by the Job Board in CRS Central at the meeting to see what’s available now! www.controlledreleasesociety.org/careers 31

Tuesday

Chair: Jaap van Harten, Elsevier, Netherlands Speakers: Kinam Park, Purdue University, U.S.A. and Jaap von Harten, Elsevier, Netherlands

Tuesday Program Highlights (continued) Roundtables and Focus Groups

Oral Drug Delivery Roundtable and Focus Group

Nanomedicine Roundtable and Focus Group

Solubility Enhancement in Oral Drug Delivery—A Breakthrough or a New Hurdle?

16:00 – 17:30 • 303A/B Chairs: Sarah Eccleston, Encap Drug Delivery, United Kingdom; and Ali Rajabi-Siahboomi, Colorcon, U.S.A.

Enhanced Permeability and Retention Effect: Opportunities and Challenges 16:00 – 17:30 • 302A/B Chairs: Hamid Ghandehari, University of Utah, U.S.A.; and Dusica Maysinger, McGill University, Canada More than 25 years have passed since the discovery of the enhanced permeability and retention (EPR) effect. This discovery has paved the way for the utility of nanosystems in clinical settings. In this roundtable, the opportunities and challenges that EPR effect presents will be discussed, followed by an open panel discussion.

Tuesday

Speakers: You Han Bae, University of Utah, U.S.A. EPR Effect: Is It Homogeneous and Predictable for Solid Tumors in Clinics?

Hiroshi Maeda, Sojo University, Japan The EPR Effect and Its Augmentation for Enhanced Tumor Drug Delivery and Imaging

Ocular Drug Delivery Roundtable and Focus Group Protein Therapeutics for the Treatment of Retinal Diseases 16:00 – 17:30 • 301A/B Chairs: Ruiwen Shi, Allergan Inc., U.S.A.; and Clive Wilson, University of Strathclyde, United Kingdom A number of retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DP), are marked by abnormal blood-vessel growth and increased vascular permeability. This roundtable discussion will focus on the challenges, opportunities, and strategies in targeted protein delivery to the posterior segment of the eye. The session will feature two invited presentations and a panel discussion following the presentations.

Speakers: Ann Daugherty, Genentech Inc., U.S.A. Sustained Delivery of Biotherapeutics to the Back of the Eye Clive Wilson, University of Strathclyde, United Kingdom The Place of Anti-VEGF Therapy in Treating Retinal Diseases

This session will review the significance of drug solubility on absorption and design it into an oral delivery system. Reports show that as high as 40–50% of new active chemical entities suffer from poor water solubility. Case studies will be provided to illustrate some of these challenges and potential approaches to overcome them. Please join us to hear from industry leaders on this hot topic and share your experiences during the roundtable discussion.

Speakers: Kevin Edgar, Virginia Tech, U.S.A. Polysaccharides for Amorphous Solid Dispersions—What Can They Achieve, and How? Sherry Ku, TWi (Anchen) Pharmaceuticals Inc. and TWi Biotechnology, U.S.A. Is Solubility Enhancement Really Required? Interplay Between Solubility and Permeability in the GI with Food Effect Navnit Shah, Hoffmann La-Roche, Inc., U.S.A. Challenges and Opportunities of Oral Delivery of Poorly Soluble Drugs

CRS President’s Banquet Politicians, Athletes, Scientists, and iCRS

18:30 – 22:00 • Hilton Québec, Ballroom

Speaker: Kinam Park, Showalter Distinguished Professor of Biomedical Engineering & Professor of Pharmaceutics, Purdue University, U.S.A. Don’t miss this rare opportunity to be entertained and educated by one of CRS’ most distinguished members during his presentation “Politicians, Athletes, Scientists, and iCRS.” Join your colleagues for an elegant evening showcasing French Canadian cuisine and culture at the Hilton Quebec.

Entertainment will be provided by Abysse Quartet; professional musicians from Les Violons du Roy and the Québec Symphony Orchestra. One drink ticket is included with your dinner. Cash bar available.

*Additional registration, payment, and ticket required. Advance banquet ticket purchase is strongly recommended.

Availability of onsite banquet tickets cannot be guaranteed.

32

Your CRS Membership: Your Access to the Future of Delivery Science and Technology Your membership is your all-access pass to leading research and the delivery science community.

Innovative Research From the research presented in the journals Drug Delivery and Translational Research and the Journal of Controlled Release, to the science presented at the CRS Annual Meeting & Exposition, to books and online webcasts, CRS is your source for the best delivery science and technology research.

Targeted Networking The CRS Annual Meeting & Exposition is just the beginning of the great opportunities to connect with delivery scientists. Utilize the online community through the website, find experts through the LATTE database, join a committee, connect on LinkedIn, or join your local chapter, and access one of the most valuable resources – each other.

Career Advancement

Test tubes and shampoo images courtesy of istock.com. Eye drops courtesy of Comstock.

Advance your professional skills through volunteering, participating in the mentor-protégé program, and more. CRS offers fellowship programs and recognition through awards. The new online career center is one more chance to develop your career in delivery science.

Take advantage of everything CRS membership has to offer now. Not a member? Learn more and join today in CRS Central. www.controlledreleasesociety.org

Podium • Tuesday Morning 301A/B

303A/B

205A/B

Bioactive Materials: DNA and RNAi Delivery

Bioactive Materials: Drug Delivery to the Brain

Bioactive Materials: Intracellular Processes

A Hatefi, H Harashima 10:30

S Boridy, J Kreuter

R Mrsny, A Kim

Tuesday

48 Invited Speaker: Development of 53 Invited Speaker: The blood-brain biodegradable peptide-based polymers barrier, a bridge too far? for nucleic acid delivery to the CNS L Lecanu D Chu, J G Schellinger, J Shi, H Wei, D McGill University, CANADA Sellers, P Horner, S H Pun University of Washington, U.S.A.

58 Invited Speaker: Sub-Cellular Transport of Drug Delivery Systems: an Intricate Road S Muro University of Maryland, U.S.A.

11:00

49 Development and In Vivo Expression of PEGylated Polyacridine Polyplexes K G Rice, K Kizzire, S Khargharia University of Iowa, U.S.A.

54 PET-based approaches to studying the size-dependence of leptomeningeal drug clearance E Belova, L Vallance, V Belov, M Gagne, C Gillooly, M Papisov Massachusetts General Hospital, U.S.A.

59 PLGA micro or nanoparticles differently induce inflammatory response in murine macrophages R Nicolete, D F dos Santos, L H Faccioli Oswaldo Cruz Foundation, BRAZIL

11:15

50 Local Delivery of Anti-Apoptotic BNIP3 siRNA by BioreduciblePolymers Retains Heart Function after Myocardial Infarction in Rats A N McGinn, D A Bull, S Kim University of Utah, U.S.A.

55 Enhanced brain delivery of liposomal 314 New insight of microbubbles-cell methylprednisolone is beneficial for interactions during sonoporation the treatment of neuroinflammation in process an animal model of multiple sclerosis L PIGEON, A Delalande, S Kotopoulis, M C C Appeldoorn, P J Gaillard, J Rip, R Postema, P Midoux, C PICHON Dorland, S van der Pol, G Kooij, H E de Centre de Biophysique Moléculaire UPR Vries, A Reijerkerk 4301 CNRS, FRANCE to-BBB technologies BV, NETHERLANDS

11:30

51 Generation of protective immune response against the P815 tumor by DNA electrotransfer G Vandermeulen, C Uyttenhove, E De Plaen, B Van den Eynde, V Preat Univ Catholique de Louvain, BELGIUM

56 Delivery of enzyme replacement 61 Optimization of quantitative tools to therapeutics to CNS in rats and study Polymer Conjugate cell monkeysas seen and measured by PET trafficking M I Papisov, V Belov, A Fischman, J A Armiñán, M Vicent, C Deladriere, M Titus, M Gagne, P Calias, T McCauley, M Palomino, A Pineda Heartlein Polymer Therapeutics Lab, SPAIN Massachusetts General Hospital and Harvard Medical School, U.S.A.

11:45

52 High-content screening of peptide57 Zero-order Release of A Novel based non-viral gene delivery systems Antipsychotic from PLGA-based M de Raad, E A Teunissen, D Lelieveld, D Microsphere A Egan, E Mastrobattista L WANG, X ZHAO, X LIU, D WANG, Z University of Utrecht, NETHERLANDS SU, F SUN, Y LI Jilin University, PRC PEOPLES REP OF CHINA

10:45

12:00

34

End of Session

End of Session

62 Intercellular transfer of nano and micro-particles in endothelial cells.

S Ferrati, A C Mack, N Sirisaengtaksin, J Schmulen, H D Summers, P Rees, X Liu, A J Bean, M Ferrari The Methodist Hospital Research Institute, U.S.A.

End of Session

Podium 202

302A/B

C&DP: Consumer and Industrial Applications of Nanoparticle Technology

Mini Symposia: Morphologies and Cell Responses

R Schmid, J Oxley

63 Invited Speaker: Advances of Submicron Particle Technologies for Consumer and Industrial Applications F Zeng The Dow Chemical Co, U.S.A.

10:45

68 Invited Speaker: The role of nanoparticle design in mediating blood and cellular interactions, and tumor targeting W Chan Toronto University, CANADA

69 (10:50) Invited Speaker: Toxicity, Cellular Uptake, and Biodistribution of Inorganic Nanomaterials: Does Shape Matter?

H Ghandehari, T Yu, H L Herd, A Gormley, A Ray University of Utah, U.S.A.

11:00

64 Mild drying and encapsulation by electrospinning R H Tromp NIZO Food Research, NETHERLANDS

11:15

65 ART nanocrystals - a novel simple method for the production of nanocrystals in industrial scale R Chen, Ö Kumanova, C M Keck, R H Müller Free University of Berlin, GERMANY

70 (11:10) Invited Speaker: Engineering Morphology of Drug Carriers for Controlling Biological and Therapeutic Outcomes S Mitragotri University of California, U.S.A.

11:30

66 Improvement of In Vitro Efficacy of Ascorbyl Glucoside by Encapsulation in QD Compliant Cationic Liposome F Durieux, I Bonnet, N Godard, E Nappi, B Vogelgesang, V André-Frei BASF Beauty Care Solutions, FRANCE

71 Invited Speaker: Three-Dimensional DNA Structures: Loading and Selective Release of Cargo and Enhanced Cellular Uptake H Sleiman McGill University, CANADA

11:45

67 Encapsulated liquid lubricants for production of self-lubricating surfaces R Schmid, S Armada, S Equey, H Johnsen, N Espallargas SINTEF Materials and Chemistry, NORWAY

12:00

End of Session

Tuesday

10:30

W Hennink, T Minko

End of Session

Cosponsored by Coating Place Inc.

35

Podium • Tuesday Afternoon 205A/B

Bioactive Materials: Inorganic Nanosystems W Chan, C Caramella 13:30

301A/B

Bioactive Materials: Oncology and Tumor Targeting K Greish, G Kwon

303A/B

Bioactive Materials: Transdermal Drug Delivery S Mitragotri, M Prausnitz

Tuesday

72 Invited Speaker: Gold Nanoparticles for Drug, Gene and Protein Delivery V M Rotello University of Massachusetts, Amherst, U.S.A.

76 Invited Speaker: Design of a produg of mitomycin C for liposomal delivery: From bench to bedside A Gabizon, Y Amitay, H Shmeeda Shaare Zedek Medical Center and Hebrew University, ISRAEL

81 Invited Speaker: Improving the Bioavailability of Topically and Transdermally Delivered Drugs R H Guy University of Bath, UNITED KINGDOM

14:00

73 Comparison of mesoporous silicon micro- and nanoparticles for subcutaneous peptide delivery J Mönkäre, M Kovalainen, E Mäkilä, M Kaasalainen, K Herzig, V Lehto, J Salonen, K Järvinen University of Eastern Finland, FINLAND

77 Uncovering tumor-host molecular and cellular interactions involved in tumor dormancy using polymer therapeutics G Tiram, E Segal, R Shreberk, G Bachar, P Ofek, L Edry, N Shomron, H Pan, P Kopečková, J Kopeček, T Udagawa, R Satchi-Fainaro Tel Aviv University, ISRAEL

82 Imaging Topically Applied Particles to Porated Skin with Coherent Raman Scattering and Two Photon Fluorescence Microscopy N A Belsey, L Contreras-Rojas, G J Price, N L Garrett, J Moger, R H Guy University of Bath, UNITED KINGDOM

14:15

74 Target Specific Systemic Delivery of siRNA and Interferon a Using Gold Nanoparticles for the Treatment of Liver Diseases M Lee, K Park, J Yang, S Hahn POSTECH, SOUTH KOREA

78 Mixed Micelles of Triblock Copolymers 83 Clinical Assessment of AK following for overcoming multidrug resistance in Levulan and BLU-U Photodynamic cancer Therapy after Pre-treatment with a T Kim, C W Mount, B W Dulken, M Du, W Sterile, Plastic Microneedle Device Gombotz, S H Pun (MSSTM) Korea Institute of Industrial Technology, K Hansen, C Novak, C Moeckly, T Martin KOREA 3M Drug Delivery Systems, U.S.A.

14:30

304 Nanocomposites Based On Montorillonite, Chitosan And Silver Sulfadiazine Intended For Wound Healing G Sandri, M Bonferoni, C Aguzzi, P Cerezo, F D'Autilia, S Rossi, F Ferrari, C Viseras, C Caramella University of Pavia, ITALY

79 Electrophoretic Disruption of Nonspecific Peptide Interactions with MMP-Sensitive Hydrogels Y Zhang, R A Gemeinhart University of Illinois, U.S.A.

84 Localized Drug Delivery through Mammary Papilla K Dave, P Sahdev, O Perumal, K Bruns South Dakota State University, U.S.A.

14:45

75 In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface charge T Yu, D Hubbard, A Ray, H Ghandehari University of Utah, U.S.A.

80 Development of novel tumoral pH responsive nanoparticles for cancer therapy S Hama, S Itakura, M Nakai, K Nakayama, S Morimoto, H Tsuchiya, K Kogure Kyoto Pharmaceutical University, JAPAN

85 Induced Accumulation of Diflucortolone Valerate in Rat Skin by Lecithin-Chitosan Nanoparticles T Senyigit, I Ozcan, M Ozyazc, O Ozer Ege University, TURKEY

15:00

End of Session

End of Session

13:45

End of Session

Cosponsored by Mylan Technologies Inc.

36

Podium 202

C&DP: Nutraceuticals and Functional Foods A Calahan, C Frey 86 Invited Speaker: Lab to Factory – How Many Steps?

H S Wheeler Color Wheel Inc., U.S.A.

T Virgallito Invited Speaker: To be announced

92 (13:50) Invited Speaker: Smart Textiles - Peroxide Functionalized Fabrics Provide Durable Antimicrobial Efficacy in Challenging Environments B Liesenfeld, W Toreki, D Moore, S Leander, A Mikhaylova Quick-Med Technologies Inc., U.S.A.

13:45

14:00

665 Determination for Moisture Permeation in Film Coating B K Cheng, B Schad, E Van Ness, T Riley Department of Pharmaceutics, Shiraz Sensient Technologies Inc., U.S.A.

14:15

88 The Influence of Calcium Carbonate in Tablet Coating Systems B A Schad Sensient Technologies, U.S.A.

14:30

89 Formation of Riboflavin/β-lactoglobulin 94 Invited Speaker: Microcapsule Delivery Nanocomplex and Impact on Systems for Textile Applications Riboflavin’s Photo-Activation T Virgallito F Diarrassouba, L Liang, G E Microtek Labs Inc., U.S.A. Remondetto, M Subirade Université Laval, CANADA

14:45

90 Multilayer alginate-chitosan microcapsules for the effective oral delivery of probiotic Bifidobacterium M T Cook, G Tzortzis, V V Khutoryanskiy, D Charalampopoulos University of Reading, UNITED KINGDOM

15:00

End of Session

Tuesday

13:30

302A/B

Mini Symposia: Smart Textiles

93 (14:10) Invited Speaker: Understanding Compression Burn and Achieve High Thermal Protective Performance G SONG University of Alberta, CANADA

End of Session

37

Daily Schedule Wednesday, July 18 07:00 – 08:00 07:30 – 12:00 08:00 – 11:30 08:00 – 09:30

09:00 – 12:00 09:45 – 11:00 12:00 – 16:00

Books Committee Meeting CRS Registration Open CRS Central Open Scientific Sessions • Bioactive Materials: Stem Cell and Regenerative Medicines • Bioactive Materials: Theranostics and Cancer Nanotechnologies • Bioactive Materials: Translational Nanomedicine • Bioactive Materials/C&DP: Nanofibers/Nanoparticles • Mini-Symposium: New Chemistries—Click It, Fit It, Test It Foundation Board Meeting Plenary Session: Vladimir P. Torchilin Educational Workshop: Considerations for Future Regulatory Submissions of Transdermal Products* Cosponsored by AVEVA Drug Delivery Systems Inc.

304B Floor 4, Main Hall Floor 4, Loggia 303A/B 301A/B 205A/B 202 302A/B 304B 303A/B 205A/B

Wednesday Program Highlights Plenary Speaker

Educational Workshop

Targeting Cell Organelles

Considerations for Future Regulatory Submissions of Transdermal Products

Moderator: Mark Tracy, Tracy BioConsulting, U.S.A.

12:00 – 16:00 • 205A/B

09:45 – 11:00 • 303A/B

Vladimir Torchilin, Distinguished Professor and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, U.S.A.

Cosponsored by AVEVA Drug Delivery Systems Inc. Chaired by: Tapash Ghosh, FDA, U.S.A.

Awards presented prior to the plenary will include the Outstanding Annual Meeting Abstract Paper Awards to Craig Duvall of Vanderbilt University, Angel Tan of Ian Wark Research Institute, M. I. Papisov of Massachusetts General Hospital, and Gerold Lukowski of Institute of Pharmaceutical Biology, Greifswald. Outgoind CRS Board members will also be recognized.

39

Wednesday

*Additional registration, payment, and ticket required.

Podium • Wednesday Morning 202

Bioactive Materials/C&DP: Nanofibers/Nanoparticle R Versic, C Berkland

303A/B

Bioactive Materials: Stem Cell and Regenerative Medicines M Shoichet, R Gemeinhart

301A/B

Bioactive Materials: Theranostics and Cancer Nanotechnologies G Storm, Z Lu

95 Invited Speaker: High Voltage Output Nanogenerator Based on PZT Nanofibers Y Shi Stevens Institute of Technology, U.S.A.

100 Invited Speaker: Engineering Bioactive 105 Invited Speaker: Carbon Nanotubes Materials to Control Stem Cell Selffor Theranostic Applications Renewal and Differentiation X Chen D Schafer National Institutes of Health, U.S.A. University of California, U.S.A.

08:30

96 Nano-Structured Microparticles for Prolonged Residence Time on Preocular Surface C Park, M Park, J Lee, S Lee, G Shin, Y Choy Seoul National University, SOUTH KOREA

101 Towards in situ Tissue Engineering: A PLGA-based chemokine delivery device for stem cell recruitment K Andreas, R Zehbe, R Georgieva, S Mueller, H Schubert, M Sittinger, J Ringe Charité University Medicine Berlin, GERMANY

08:45

97 Polymeric Nanofibers Co-loaded with Fusidic Acid & Rifampicin for the Prevention of Implant Associated Infections S E Gilchrist, D Lange, H Bach, L Fazli, Y Av-Gay, H M Burt University of British Columbia, CANADA

102 Controlled Release of Bioactive PDGF- 107 Ultrasound-Induced Release from AA from PLGA Nanoparticles eLiposomes at 20 kHz I Elliott Donaghue, T Zahir, M S Shoichet W G Pitt, J R Lattin University of Toronto, CANADA Brigham Young University, U.S.A.

09:00

98 Functionalized Nanoparticle Release and Distribution in PEG Hydrogel Delivery Systems S L Hume, J L Blacklock, K M Jeerage National Institute of Standards and Technology, U.S.A.

103 Evaluation of Antibiotic-releasing 108 Gas-Generating Calcium Carbonate Porous Polymethylmethacrylate Space Mineralized Nanoparticles for Maintainers in an Infected Composite Ultrasound Imaging Tissue Defect K Min, S Jeong, S Lee P P Spicer, A M Henslee, L A Kinard, B M Kyung Hee University, SOUTH KOREA Watson, J D Kretlow, K Bevil, L Katchee, J A Jansen, M E Wong, F K Kasper, A G Mikos Rice University, U.S.A.

09:15

99 Cross-linked Resins by Stepwise Polyaddition of β-Cyclodextrin with Bisacrylamides and Assessment of Their Potential as pH-Sensitive NPs for Site-Specific Protein Delivery E Ranucci, P Ferruti, A Manfredi, R Cavalli University of Milan, ITALY

104 The effect of exopolysaccharides extrated from Botryosphaeria rhodina on bone tissue enginerring H Chang Chiayi University, TAIWAN

09:30

End of Session

08:00

08:15

Wednesday

40

End of Session

106 Tumor Cell-Specific Delivery of Paclitaxel Using a Self-assembled Matrix Metalloprotease 2-sensitive Nanocarrier L Zhu, A Taigind, V P Torchilin Northeastern University, U.S.A.

109 Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy H Hatakeyama, K Takara, G Kibria, N Ohga, K Hida, H Harashima Hokkaido University, JAPAN

End of Session

Podium 205A/B

302A/B

Bioactive Materials: Translational Nanomedicine

Mini Symposia: New Chemistries Click It, Fit It, Test It

A Gabizon, Y Bae 110 Invited Speaker: Targeting G ProteinCoupled Receptor Folding and their Export from the Endoplasmaic Reticulum for the Treatment of Conformational Diseases M Bouvier, P René, É Sauvageau, M Palardy, J Morello, V Bernier University of Montréal, CANADA

08:15

115 Invited Speaker: Combinatorial development of biomaterials and synthetic siRNA delivery systems D G Anderson MIT, U.S.A.

116 (08:20) Invited Speaker: A Bioactive Peptide that signals against Phagocytic Clearance to Maximize Delivery D E Discher University of Pennsylvania, U.S.A.

08:30

111 In vivo assessment of salmon calcitonin nanoparticles delivered by the intra-articular route for treatment of inflammatory arthritis in the K/BxN mouse model S M Ryan, H Patel, K Kornerup, A Umerska, L Tajber, M Perretti, D J Brayden University College, IRELAND

08:45

112 Usability and Acceptability of a 117 (08:40) Invited Speaker: AzlactonePlacebo Microneedle Patch for SelfContaining Polymer Multilayers as Vaccination Against Influenza in Naïve Reactive, Modular, and Tunable Human Subjects Platforms for Surface-Mediated Drug J J Norman, M A McClain, P M Frew, M R Delivery Prausnitz D M Lynn Georgia Institute of Technology, U.S.A. University of Wisconsin, U.S.A.

09:00

113 Loperamide-Formulated Immunoliposomes Directed Towards Intercellular Adhesion Molecule-1 (ICAM-1): A Potential Tool for Specific Drug Delivery to Peripheral Inflammatory Pain S Hua, P J Cabot University of Newcastle, AUSTRALIA

09:15

658 PLGA Nanoparticle PropertyBiodistribution Relationships and In Vivo Degradation M Li, A Mohammad, J Reineke Wayne State University, U.S.A.

09:30

End of Session

Wednesday

08:00

M El-Sayed, B Amsden

118 Invited Speaker: Nanoscale Amphiphilc Macromolecules: Designing compounds to inhibit oxidized low-density lipoprotein uptake K Uhrich Rutgers University, U.S.A.

End of Session

41

2012 CRS Posters Cosponsored by AstraZeneca Scientific posters are an essential element of the CRS Annual Meeting & Exposition. The display of posters allows annual meeting attendees an excellent opportunity to share with one another important scientific achievements and learn the newest technologies in delivery science on a personal basis. Each submitted poster abstract is peer reviewed and chosen based upon predetermined selection criteria. Poster abstracts are located on the CRS website, mobile app, and at the abstract printing station.

All scientific posters will be on display throughout the meeting during exhibit hours. Poster authors will be present during one of three pre-specified time slots, during which complimentary beverage tickets can be redeemed at the café.

Poster Sessions (authors present) Poster Session 1 Monday, July 16 09:30 – 10:30 Poster Session 2 Tuesday, July 17 09:30 – 10:30 Poster Session 3 Tuesday, July 17 15:00 – 16:00

Poster Session I Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization 119

Analysis of particle agglomeration and content uniformity by Raman imaging

125

Study on Hollow Silica Nanospheres as Ultrasound Contrast Agent

Bioactive Materials: Biomaterials

197

Preparation and Characterization of Magnolol Loaded Polyketal Microparticles

200

Release of Dihydroxyacetone from Poly(carbonate-ester)s Using the Bicinchonic Acid Assay for α-Hydroxy Ketone Quantification

203

Screening for claudin-4 modulators by using a reporter assay system

206

Surface functionalization of PLGA nanoparticles with hydrophobic anchored poly(ethylene glycol) co-polymers

209

The Influence of Cellulose Acetate Weight Gain and Solvent Ratio on Performance of Push-Pull Osmotic Pump Tablets

212

Tunable Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering

131

A Stable Formulation of Glucagon for Pump Use

137

Biodegradable Thermoresponsive Nanogels as Intravitreal Injection Carrier for Bevacizumab

140

Carboxymethylchitosan and poly(γ-glutamic acid) conjugated stimuli-responsive polymers for protein delivery

143

Chitosan/Alginate Composite Scaffolds Based on Microparticles

146

Control of Microparticles Morphology for Tunable Drug Release

218

149

Controlled release of chondroitinase ABC to the injured spinal cord

Anticancer activity of miR-34a encapsulated into SNALPs or transferrin-conjugated SNALPs

221

152

Cross-linked Nanoassemblies for Customized Drug Delivery

Bio-nanocapsule-liposome complex showing excellent in vivo transfection efficiencyin a human hepatic cell-specific manner

155

Development of a Subcutaneous Implant using Polyurethane as a Semi-Permeable Membrane for the Controlled Release of Risperidone

224

Bioreducible Polyether-based pDNA Ternary Polyplexes: Balancing Particle Stability and Transfection Efficiency

230

158

Drug release control of photo-sensitive smart hydrogels driven by pH-jump reaction

Computational Pharmaceutics - the Application of Molecular Modeling in Drug Delivery

233

161

Enhancement of immune activation and antitumor efect by carbon nanotubes / CpG DNA oligonucleotides complexes with NIR laser irradiation

Controlled release of BMP-2 to Mesenchymal Stem Cell for bone regeneration

236

Delivery of siRNA to Cancer Cells Using Interleukin-4 Receptor Targeted Peptide-Conjugated BPEI-SPION Nanoparticle Complex

164

Evaluation of a Perforated Drug Delivery System in Mice for Prolonged and Constant Release of a Hydrophilic Drug

239

167

Impact of Polymer Physico-chemical Properties on PEG-graftedPLA Nanoparticles Structure

Development of redox-sensitive, core-crosslinked, hTERT siRNA loaded polyethylene glycol grafted polyethyleneimine nanoparticles

245

170

In Vitro Degradation of Double-Walled PLA(PLGA) Microspheres

Efficient protection and increased gastrointestinal deposition of siRNA after oral administration of siRNA/chitosan nanoparticles

173

Inhalable Engineered Erythrosomes as Natural Nano-Reservoirs of a Rho-kinase Inhibitor, Fasudil

251

Grapheme oxide(GO)-Polyethylenimine (PEI) conjugate as a gene delivery carrier and imaging agent

176

Injectable, in-situ gelling,cyclodextrin-dextran based hydrogels for the release of hydrophobic drugs

254

In vitro Silencing Activity of Amphiphilic Antisense Oligonucleotides

179

Liposomes prepared from bixin as amphotericin B delivery system

257

182

Modulating the rheological properties of hydrogels composed of blends of hydroxyl- and hexanoyl-PCLA-PEG-PCLA triblock copolymers

Injectable Polyplex Hydrogel for Localized and Long-term Delivery of siRNA

260

LinOS/cholesterol - a non-toxic vector for the delivery of siRNA effecting quantitative silencing of EGFP in HeLa cells

185

Nattokinase, an Enzyme from Japanese Food, Increases Epithelium Permeability

263

MMP-Responsive, Proximity-activated Targeting Polymeric Nanoparticles for siRNA Delivery

188

On-demand, targeted drug delivery using magnetic thermosensitive nanocomposites

266

Myocardial Ischemia Gene Therapy Using Post-translational Regulated and Hypoxia-responsible VEGF Plasmid

191

Peptide-linked Targetable Nanoparticles of Tissue Plasminogen Activators for Localized Thrombolysis

269

Novel pH-sensitive carbonate apatite nanoparticles as intracellular Gene/Drug transporter

194

Polyurethane as a Semi-Permeable Membrane for Controlled Release

272

PEGylated Solid Lipid Nanoparticles: A Promising Carrier for siRNA delivery to Carcinoma Cells

42

Bioactive Materials: DNA and RNAi Delivery

275

Polymeric micelle-based antioxdative transfection system for highly enhanced gene transfection

380

Mucoadhesive Nanoparticles as Carrier Systems for Sublingual delivery of Glutathione

278

siRNA Delivery into a Breast Orthotopic Xenograft Using a Tumor-Targeted Polymeric Nanoparticle (PNP) Following Systemic Administration

383

Multimeric Fullerenes for Rheumatoid Arthritis Therapy

386

Nanosizing of Nystatin for an Improved Antifungal Efficacy

389

Oligonucleotide@Doxorubicin Nanoaggregates with Multiple Responsiveness toward Intracellular Release

392

Optimization of ophthalmic cyclosporine A nanoemulsion using in situ hydrogel system

395

Pancreatic Polypeptide in Phospholipid Micelles Exhibits Enhanced Stability Against Proteolytic Degradation and Retains its Bioactivity In Vitro

281

Structure-dependent Lysosomal Transit of Chitosan-pDNA Polyplexes

284

Surface Modified Polymer Nanoparticles for Enhanced Delivery of Microbicidal siRNAs

287

The Development of Rath cell penetrating peptide-dendrimer Gene Delivery Systems

290

Transferrin-targeted Phospholipid-modified PEI-based Micellar Nanocarriers for Dual Delivery of siRNA and Anticancer Drugs

398

Peroral Delivery of 10-Hydroxycamptothecin-loaded polymeric nanomicelles

709

Investigating the depot-formation of cationic liposome-based DNA vaccines

401

PLGA Nanoparticles Meet the Bronchial Airways: How Surface Properties Affect Their Interaction with Mucus and Epithelial Cells

404

Polymeric Chitosan-based Vesiclesas pH-responsive Drug Delivery System

407

Preparation and Characterisation of pH-responsive Polymeric Micelles Incorporating the Proteasome Inhibitor MG132 for Efficient Cancer Therapy.

410

Reductive-sensitive tioguanine prodrug micelles

413

Simple and Effective Targeting for Programmed Erythrocyte Death

by Using Cationic Liposomes

416

Surface Modification of Gelatin Nanoparticles with Polyethylenimine as Drug/Gene Vectors

419

The control of T cell mediated immunity by anchorage effect using multi-segmented nanorod

425

Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment

Bioactive Materials: Drug Delivery to the Brain 293

Controlled Delivery of Cyclosporin A to the Stroke-Injured Brain

296

Glutathione PEGylated Liposomes to Safely Enhance the Delivery of Drugs to the Brain

302

Zolimitriptan Transbuccal Delivery by a Dissolving Microneedle Patch

Bioactive Materials: Inorganic Nanosystems 305

Novel Technology for Taste Masking : Applied to Sildenafil Citrate

Bioactive Materials: Intracellular Processes 308

Elucidating uptake and intracellular trafficking of PolyrotaxanesiRNA nanoplexes

311

In Vivo Performance of Nanocarriers Dually-Targeted to Epitopes of the Same Versus Different Receptors

Bioactive Materials: Nanomedicines

Bioactive Materials: Oncology and Tumor Targeting 431

3D Superhydrophobic Electrospun Materials for Prolonged Drug Delivery of SN-38 in Colorectal Cancer Treatment

437

Anti-tumour effect of Sirolimus stealth liposomes on human breast cancer cells (BT-474)

317

“Smart” Micelles for Reactive Oxygen Species Triggered Drug Release

446

Design and Development of Tumour-targeting Solid Lipid Nanoparticles for a Novel Inhibitor of Nedd8-Activating Enzyme

323

Advanced Spray Dried Microparticulate/Nanoparticulate Inhalable Polymeric Lipospheres Containing Paclitaxel for Targeted Pulmonary Nanomedicine in Lung Cancer Treatment

449

Development of Functionalized Iron Oxide Nanoparticles for Cancer Detection

452

326

Backbone degradable HPMA Copolymer-Gemcitabine Conjugates for the treatment of Ovarian Cancer

Enhanced Anticancer Activity by Specific Target Effect using anti-HER2 antibody and LMPXPEG

455

In Vivo Stability of an Injectable Antibody Displaying System

329

Cancer cell targeted self-quenching pullulan/folate-photosensitizer conjugates for photodynamic therapy

458

New self-assembling nanoparticles for bisphosphonate and nucleic acid delivery in cancer

332

Co-delivery of Bupivacaine-HCl and pH-modulating Agents through Micro-fluidic Channels for Enhanced Control of Drug Release

461

Phosphatidylcholines in Anticancer Drug Delivery - mere innocent Bystanders?

464

335

Cryo Transmission Electron Microscopy as an Orthogonal Tool for Characterization of Nanoparticle Drug Delivery Systems

Potential of Angiogenesis Target using Cationic polymer and RGD Peptide

467

338

Dendrimer Nanocarriers For Transport Modulation Across the Airway Epithelium

Sequential dose of l-OHP containing PEGylated liposome improve the intratumor delivery and efficacy of PEGylated liposomal anticancer agents.

341

Design and Evaluation of Folic acid Conjugated Docetaxel Loaded Nanoparticles

476

Three Dimensional Spheroid Culture: Evaluation and Comparison of Cancer Cell Behavior

344

Development of Biodegradable Microneedle Cuff for Vascular Diseases

479

Use of macrophages as a tool for delivery of therapeutic and imaging contrast agents to tumors

347

Development of Polyion Complex Vesicles “PICsomes†toward a Versatile Platform for Delivery of Biomacromolecules and Nano-materials

706

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

353

Encapsulation of Amphotericin B into PEG-grafted-PLA Nanoparticles: Characterization and Anti Fungal Efficacy

359

Evaluation and Characterization of Milrinone-loaded PEG-graftedPLA Nanoparticles Intended for Pulmonary Delivery

Bioactive Materials: Oral Controlled Release 485

A Taste Masking Coating Using CelluloseDerivatives

488

Bioavailability Enhancement of Itraconazole with Solid Solutions based on Polyethylene glycol-Polyvinyl Caprolactam- Polyvinyl Acetate Graft Copolymer

362

Evaluation of Micelles and Liposomes in an In-Vitro Articular Cartilage Explant Model

365

Formulation and Optimization of the Itraconazole Lipid Polymeric Hybrid Nanoparticle by the Box-Behnken Design.

491

Characterization of nanostructured lipid carries containing Praziquantel by DSC

368

Hyaluronic acid-based nanoparticles for atherosclerosis imaging

497

371

Investigation of Sirolimus liposomes using DSC and AFM

377

Mixed micelles with enhanced stability prepared from graft and diblock copolymers for doxorubicin delivery

Comparative Study of High Viscosity Grade of Hydroxypropyl Cellulose (HPC-H) for Hydrophilic Matrix, Sustained Release Formulation

Poster Session I continued

43

Poster Session I—Bioactive Materials: Oral Controlled Release continued 500

Design of granules based on Casearia sylvestris to treatment of gastric diseases: preliminary issues.

503

Development and validation of an isocratic RP-HPLC method for determination of bovine lactoferrin and its proteolytic degradation in simulated gastrointestinal fluids

506

Bioactive Materials: Theranostics and Cancer Nanotechnologies 596

Calcium Phosphate Mineralized Self-Assembled Nanocarriers for Enhanced Photodynamic Therapeutic Efficacy

599

DEVELOPMENT OF AN EXPERT SYSTEM FOR THE PREDICTION OF CONTROLLED RELEASE FORMULATIONS

Combined Modality Doxorubicin-Based Chemotherapy and Chitosan-Mediated p53 Gene Therapy Enhances Inhibition of Hepatocellular Carcinoma HepG2 Cell Growth

602

509

Development of mucoadhesive liquid crystalline systems for buccal drug delivery using tea tree oil with oil phase

Doxorubicin Delivery to EphB4 Over-expressing Tumor via Cross-linked Polymeric Micelles

605

512

Direct in situ determination of structural aspects of rapid solvent-mediated polymorphic transitions during dissolution using synchrotron XRD

Heat Activated Nanobomb; Thermosensitive Polypeptide-Incorporated Liposome

608

Mineralized PEGylated Hyaluronic Acid Nanoparticles as Organic-Inorganic Hybrid Carrier for Cancer Therapy

515

Dissolution experiments at varying pH in presence of lipid layer to mimic absorption and using polymers to prevent drug precipitation

614

Polymeric Micelle-based Acidic pH Imaging

617

Targeted HPMA Copolymers for Image Guided Drug Delivery in Pancreatic Cancer

518

Effect of polymer properties on drug dissolution from solid dispersions : Solubility parameters and surface tention

521

Effect of Solution and Polymer Properties on Spray Dried Powder Properties

620

524

Evaluating various hydrophilic plasticisers regarding their effect on the characteristics of a gastric resistant coat based on methacrylic ethyl acrylate copolymer

A Novel Water-soluble Cyclosporine A Prodrug for Ophthalmic Application

623

Development of lipid nanostructured systems containing fluconazole: Evaluation of solubility

530

Formulation and Process Deviation Analysis for Scale Up of Extended-Release Drug Products of Abbreviated New Drug Applications by Quality Risk Management Principles (ICH Q9)

626

Effect of 1,8-Cineole on the Percutaneous Absorption of Lomerizine Dihydrochloride

629

533

Hot-Melt Microsphere Fabrication for Controlled Release of Orally Delivered Small Molecules

Efficient Intradermal Delivery of Superoxide Dismutase using a Combination of Liposomes and Iontophoresis for Protection against UV-induced Skin Damage

536

In vitro evaluation of floating ability and drug release of tablets containing magnetic marker

632

Enhancement of the transport of 5-flurouracil using submicron emulsion

539

Influence of b-Cyclodextrin Side Chain Substitutions on the Complexation Efficiency of Two Model BCS Class II Compounds

635

Formulation and in-vitro Evaluation of Terbibafine HCl Loaded Ungual Liposomal Gels

545

Investigation of Cellulose Acetate Polymer Viscosity and Coating Solution Concentration on Performance of Push-Pull Osmotic Pump (PPOP) Tablets

638

Influence of PEG on the Metabolism of Prednicarbate in Ex Vivo Human Skin

641

Microparticle and Microneedle Drug Delivery in Human Skin

548

Manufacturing and Process Controls of Controlled Release Dosage Forms-- Investigation of Post-approval Changes Required During the Product Life Cycle

644

Optimization of Pilot Scale Manufacturing of a Multi-Source Clobetasol 17-Propionate (CP) Cream

647

554

Multiple-Unit Swellable/Erodible Delivery System for Oral Pulsatile Release: Preliminary Stability and In Vivo Evaluation

Studies on in vitro Release Performance of Hydrophilic Drugs and Lipophilic Drugs in Amphiphilic SIS-based Hot-melt Pressure Sensitive Adhesives

560

Particle Engineering of Acetaminophen Via Spray Drying From Hydroalcoholic Solutions: Improvement In Dissolution Rate

650

Transdermal Insulin Delivery Enhanced by Photothermal Effect of Gold Nanorods

566

Preparation of Sustained Release Microparticles Containing Theophylline and Eudragit RS Using Spray Drying Technique: Comparison Between Organic Solution and Aqueous Dispersion of Polymer

569

Prolonged In Vitro Antifungal Effect of Nystatin-Containing Mucoadhesive Hydrogel Films

572

SOLID DISPERSIONS OF CARBAMAZPINE WITH LUTROLÂŽ F127 USING HOT MELT EXTRUSION

578

TABLETTING OF COATED MULTIPARTICULATES: EFFECT OF FORMULATION COMPOSITION, PROCESS VARIABLES ON DRUG RELEASE AND TABLET PROPERTIES

581

The Influence of Level and Location of NaCl on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug

584

Thermal and Rheological Properties of Povidone and Copovidone Polymers for Hot Melt Extrusion Application

587

Utilization of pH-Metric Titration to Evaluate the Supersaturation Behavior of Weakly Basic Drugs

Bioactive Materials: Stem Cell and Regenerative Medicines 590

44

Development of a novel drug delivery system based on Protein-Poliacetal Conjugates

Bioactive Materials: Transdermal Drug Delivery

Bioactive Materials: Translational Nanomedicine 114

Chitosan-PEG-folate-conjugated oncolytic adenovirus for targeted cancer gene therapy

653

Early translation study on LIPOMER of Doxycycline HCL - Scaleup & Optimization

C&DP: Consumer and Industrial Applications of Nanoparticle Technology 659

Analysis of Drug-Excipient Miscibility and Its Impact on Particle Formation via Spray-Drying

662

Zeta potential measurements of high concentrated fish oil nanoemulsions

C&DP: Nutraceuticals and Functional Foods 668

QbD Approach for Moisture Barrier Film Coating Development

Veterinary: Protein and Vaccine Delivery 671

An approach to a cold chain free oral cholera vaccine: in vitro and in vivo characterization of Vibrio cholerae gastroresistant microcapsules

674

Aquasomes as a Carrier System for Proteins and Peptides

677

Controlled Release of Proteins through Releasable PEGylation

680

Development of Albumin-coated Nanoparticle Carrier Systems for Human Growth Hormone

683

Evaluation of Poloxamer 407 and CpG Oligonucleotide as Adjuvants for a Pulmonary Vaccine against Tuberculosis

686

Micro/Nano particulate formulation of a novel polymer based vaccine adjuvant to stimulate cellular and humoral immune system

695

Safe and Effective Sublingual Delivery System of Recombinant Human Insulin as an Alternative to the Injection

701 Targeted Drug Delivery to the Suprachoroidal Space Using a Microneedle 704

Understanding Surfactant Interactions When Producing Niosomes

by Analytical Techniques such as Differential Scanning Calorimetry (DSC) and Langmuir Monolayer studies

Poster Session II Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization 123

Size and Count Characterization of Drug Delivery Nanoparticles

by Nanoparticle Tracking Analysis

Bioactive Materials: Biomaterials

Bioactive Materials: DNA and RNAi Delivery 216

Acid cleavable poly(β-amino esters) as a pH sensitive gene delivery system

219

Anti-PEG IgM response against PEG-coated liposome is further increased by immune stimulation of siRNA via TLR7

222

Bio-reducible Dextran-siRNA Conjugates for Stabilization, Tumor-targeting, and Intracellular Delivery of siRNA

132

A user-friendly injectable sustained-release formulation for Triptorelin

225

Calcium phosphate nanocapsule as durable gene delivery system for plasmid DNA complex

135

Biodegradable Microsphere Platform for the Delivery of Bioactive Compounds

228

Choline Kinase Targeted siRNA in PEGylated Liposome for Breast Cancer Therapy

138

Biomimeticdesign of lubricin-like polymers for lubrication of articular joints

231

Confirming RNAi-mediated Gene Silencing in tumor by PEGylated siRNA-loaded liposome with pH-sensitive cationic lipid

141

Cellular Uptake of the Cysteine-rich Cell Penetrating Peptide CyLoP-1 depends on the Availability of Exofacial Protein Thiols

234

Controlled shielding & deshielding of HES-decorated polyplexes using alpha amylase

144

Clinical and Microbiological Evaluation of Biodegradable Poly (ethylene sebacate) Periodontal Implants of Roxithromycin

237

Design and evaluation of surface modified, poly (β amino ester) containing nanoparticles for plasmid DNA delivery

147

Controlled Release and Reloading of Doxorubicin Using an Tunable Affinity-Based Polymer System

240

Dimeric siRNA Conjugates with Different Spacer Lengths for Efficient Intracellular Delivery and Gene Silencing

150

Controlling Drug Release Kinetics from Soft Nanocomposite Hydrogels

246

Elucidation of Morphology and in vitro Activity of Anionic siRNA Lipoplexes: Biophysical Characterization Studies

156

Development of fenofibrate liquid-filled capsule using melt-fusion method

249

159

Drug-delivery Surgical Sutures for Post-Surgical Pain Relief

Evaluation of carrier-mediated siRNA delivery: A novel stem-loop qPCR-based approach for intracellular full-length siRNA quantification

165

Formulation and Evaluation of Microencapsulated Hydrogen Peroxide for Controlled Release of Oxygen

252

High Transfection Efficiency by Polymannitol-based Transporter through Caveolae-mediated Endocytosis pathway

168

In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogelsfor Drug Delivery and Tissue Engineering Applications

255

In vitro/in vivo correlation analysis using siRNA-loaded lipid nanoparticles

258

174

Inhaled PLGA Particles of Erlotinib as an Alternative to Oral Erlotinib for the Treatment of Non-small Cell Lung Cancer

Injectable Thermo-responsive Hydrogel Containing LDH Nanoparticles Mediating siRNA Delivery into Chondrocytes

261

177

Lactic Acid and Carbonate-based Crosslinked Polymeric Micelles as Drug Delivery Vehicles

Lipid Nanoparticles for Inhalation Co-Delivery of Anticancer Drug and siRNA

264

Modification of Dendrimers for Enhanced SiRNA Delivery

183

Mussel-inspired Chitosan Nanogels with Enhanced Stability and Mucoadhesion for Drug Delivery

267

Natural alveolar surfactant potentiates intracellular siRNA delivery by dextran nanogels

186

Non Phospholipid Liposomes Prepared from a Monoalkylated Amphiphile and a Sterol: a Versatile Family of Nanovectors

270

Optimizing chitosan for siRNA delivery and P-gp silencing in rat brain endothelial cells

189

Oxygen delivery scaffold for tissue engineering

276

192

PLGA microsphere/PVA hydrogel coatings for subcutaneous implants: controlling inflammation in a large animal model

Preparation of pH-responsive polymers for delivery of nucleic acids

279

195

Potential of Poly (amidoamine) Dendrimers as ocular carriers of puerarin based on Human Corneal Epithelial Cell Line

Smart cytoplasm-responsive nanocarriers conjugated with a functional peptide for treating cancer by systemic siRNA delivery

282

198

Preparation, Characterization and Drug Release Assessment of Raloxifene Hydrochloride - Carboxylated Polyurethane Nanoparticles

Studying bPEI:DNA-polyplex properties and cell interactions with label-free surface sensitive physicochemical techniques

288

The Synthesis of Monodisperse, Reducible Nucleic Acid Delivery Polypeptides

201

Reverse Thermal Hydrogels based on PPO-PEO-PPOα,ωBisphosphate

204

Self-healing Kinetics of Microneedle-formed Holes in PLGA Films

207

Target Specific Hyaluronic Acid – Interferon Alpha Conjugate for the Treatment of Hepatitis C Virus Infection

291

A PET based method for real time monitoring of drug concentration in the liquid phase of the leptomeningeal compartment.

210

Thermogelling Polypeptide Aqueous Solutions for Protein Drug Delivery and 3D Cell Culture

294

Convection-Enhanced Delivery of Surface-Modified Brain-Penetrating Nanoparticles in Glioma

213

Tuning size properties in alginate/dextran sulfate particles produced by emulsification

297

In vivo administration of VEGF and GDNF releasing biodegradable microspheres in a severe lesion model of Parkinson’s disease

300

Parenteral Microemulsion of Curcumin for Brain Targeting

Bioactive Materials: Drug Delivery to the Brain

Poster Session II continued

45

Poster Session II continued

417

Bioactive Materials: Inorganic Nanosystems 306

Polymeric and non-polymeric magnetic nanoparticle uptake and gene delivery to endothelial cells

Bioactive Materials: Intracellular Processes 309

Exploring the cell penetrating ability, membrane activity and proapoptotic activity of Tat derived multifunctional peptide, Tat-LK15

312

Interaction of gold nanoparticles with neural cells

315

Nuclear Targeted Delivery of Bleomycin by Octaarginine-modified Fusogenic Liposomes for Cancer Treatment.

Bioactive Materials: Nanomedicines 318

3-in-1 Polymeric Micelles for Ovarian Cancer Treatment

321

A Novel Triblock Copolymer for Combination Delivery of siRNA/Drug

324

Amphotericin B loaded glycerol monooleate nanoparticle: Enhanced in vivo bioavailability with reduced toxicity an implication for fungal therapy

420

Synthesis and characterization of a nanoglobular dendrimer 5-aminosalicylic acid conjugate with a Schiff base spacer for treating retinal diseases The cytotoxicity of paclitaxel loaded diblock copolymer nanoparticles in multidrug resistant cells is enhanced by low molecular weight methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)

423

Trimethyl Chitosan coated Propyl Starch Nanoparticles for Gene Silencing

426

Tumor-Targeting and Boron Neutron Capture Therapy by Using Biodegradable Polyamines Conjugated with Boron Cluster

429

Water soluble polymeric xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases

Bioactive Materials: Oncology and Tumor Targeting 432

A Biophysical Transport Model To Predict The Enhanced Permeability And Retention Effect For Liposome Accumulation In Solid Tumours

435

Accumulation and biodistribution of “Stealth Liposomes” and plasmapheresis

438

Bladder Tumor-Targeted Delivery of a Pro-apoptotic Peptide

441

Chemoresistance in Prostate Cancer Cells is Regulated by miRNAs and Hedgehog Pathway

327

Biodegradable and Injectable Poly(organophosphazene)-Camptothecin Conjugate Hydrogel: Physicochemical Properties and Antitumor Activity

444

336

Cyclopamine and Gefitinib Loaded Micelles for Combination Chemotherapy of Pancreatic Cancer

Controlled water steam injection: ex vivo optimization of parameters for the ablation of liver lesions

447

342

Determination of surface hydrophobicity of cationic solid lipid nanoparticles

Design of a Novel Peptide for HER2 Targeting Based on Pertuzumab-HER2 Complex

450

345

Development of Buparvaquone Solid Lipid Nanoparticles by Green Technology

Distribution and functional analysis of Eph receptor A10 as a novel drug target for breast cancer

453

348

Diethylene Glycol (DEG) Functionalized Self-Assembling Peptides as Potential Nanocarriers for Hydrophobic Anticancer Drug Delivery

Fatty Acid-Glycosylated RGD Amphiphiles for Targeted Delivery of Paclitaxel to TumorsOverexpressingαvβ3 Integrins:In Vitro Cellular Uptake and Cytotoxicity Studies

351

Effect of particle size on endocytic uptake by alveolar macrophage cells

456

Nanocomposite particles for treatment of lung carcinoma

459

Novel C16-ADA linked RGD micelles for targeted delivery of hydrophobic agents to αvβ3 integrin receptors

354

Engineer Drug Nanocrystals to Overcome the Mucus Barrier for Mucosal Delivery

462

pH-Sensitive PEGylated Liposomes For Tumour Cell Targeting

357

Epirubicin Nanoemulsion Enhanced Intravesical Permeability and Reduced Bladder Irritation

471

Synthesis and Characterization of Active targeting Agent using Transferrin for Cancer Therapy

360

Evaluation of a Novel Anti-inflammatory Estradiol-Loaded Omega-3-Fatty Acid Oil Containing Nanoemulsion Formulation for the Treatment of Atherosclerosis

474

Targeting Ligand-directed Micellar Nanocarriers for R547: Enhanced Binding and Increased Cytotoxicity to Cancer Cells

363

Formation of Cationic Non PhospholipidLiposomes with Monoalkylated Primary Amine and Cholesterol

366

Formulation of Docetaxel using Prodrugs for Intravenous Delivery

480

369

Influence if Solvent, Stabilizer, and Stabilizer’s Concentration on the Physical Properties of PLGA Nanoparticles

A Hydrophilic Matrix Generated by Direct Compression and Thermal Treatment: Application in Press-Coating

483

372

Liposomal Form of Prostaglandin E2 for Inhalation Treatment of Pulmonary Fibrosis

A novel porous starch based self-assembled nano-delivery system improves the oralabsorption of insoluble probucol in rats

486

375

Micro-fluidic Structures for Zero-order and Sequential Drug Delivery

378

Modified Gemcitabine-loaded lipid nanocapsules: when a drug participates to the structure of a nanomedicine

Barrier Membrane Coating of Hydrophilic Matrices of a Very Soluble Drug, Metoprolol Tartrate at High Dose: A Strategy to Eliminate the Initial Burst Release

489

Buccal delivery of insulin used a novel mucoadhesive polymer

492

Characterization of the Mechanical Properties of High Drug Loading Pellets for Compressed CR Tablets

495

Coated pellets containing chitosan for colon targeting

498

Compatibility studies with tablet excipients in solid state using Raman spectroscopy, X-ray and Scanning electron microscopy

Bioactive Materials: Oral Controlled Release

381

Multifunctional PEGylated 2C5-Immunoliposomes Containing pH-sensitive Bonds and TAT Peptide, in vitro and in vivo Activity

384

Nanoencapsulation of Tea Polyphenol into Biopolymeric Complex Coacervation Core Micelles

387

New protocol to evaluate release in lipophilic medium: story of misinterpretation related to the use of fluorescent dyes

501

390

Optimization of a Novel Nanostructured Lipid Carriers for Ocular Herpes Simplex Keratitis

Design of Maillard Conjugates-Stabilized Chitosan Nanoparticles for Colon-specific Oral Delivery System

504

393

Oral Absorption of PAMAM-SN38 Conjugate in Mice

Development of a Pulsatile Release Multiparticulate System for Delivery of Ondansetron

399

pH/Thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for focused ultrasoundtriggered release of doxorubicin

507

Development of Injection-Molded Swellable/Erodible Capsules for Oral Pulsatile Release

516

Dissolution of Ranolazine ER tablets under standard and biorelevant mechanical stress conditions

519

Effect of different excipients on the pharmacokinetics of polydatin in Beagle dogs after orally administration of Complex Polygonum Cuspidatum Capsules

522

Encapsulation Prevents Chemical Incompatibility in Combination Therapy

402

Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to resistant cancer

405

Polymeric Nanoparticles of Lopinavir to Improve its Oral Bioavailability

411

Self-assembled Lipid Nanocapsules for Co-delivery of Paclitaxel and Bcl-2-targeted siRNA

46

525

Evaluating various insoluble components regarding their effect on the processability and charac-teristics of a gastric resistant coat based on methacrylic ethyl acrylate copolymer

Bioactive Materials: Transdermal Drug Delivery 621

Extended release acetaminophen- psyllium husk matrix tablet and the effect of additives on the drug release rate kinetics and mechanism

Activity of novel lithium carbonate formulations against drug-resistant isolates of skin and wound-associated methicillin-resistant S. aureus: Proof-of concept and mechanism of action

624

Development of Solid Lipid Nanoparticles for Cutaneous Administration of Trans-resveratrol

534

Improved oral bioavailability of risedronate by DA-1, as a novel absorption enhancer

627

Effect of Stretching on Drug Transport Across Human Stratum Corneum

537

In vivo and in vitro evaluations of lipid matrix nanoparticles containing fenofibrate

630

Electrically-Controlled Drug Release System to Assist Wound Healing

633

Finite Element Modeling of Drug Transport Through the Human Stratum Corneum

636

Improving cutaneous delivery of paclitaxel: effect of protein transduction domain, composition and structure of microemulsions

639

In-Vitro Drug Release Testing: Challenges for Drug Eluting Stents (DES)

645

Prevention of the dermal colonization of MRSA by the application of algae microparticles

528

540

Influence of solvents on the characteristics and drug release of microparticles prepared using electrospraying

543

Investigation effect of sodium Meta bisulphite and various filler types on release stability of diltiazem hydrochloride containing Poly ethylene oxides

546

InVitro Release Behavior of Insulin in the IPN Hydrogel as Oral Drug Delivery

549

Mesalamine-Novel Delayed Delivery System

552

Monitoring Drug Release from Self-emulsifying Drug Delivery Systems Real TIme during In Vitro Formulation Digestion: A Modeling Approach

555

Oral Delivery of Multiple Drugs from a Multi-Reservoir Bioadhesive Microdevice

558

Orally Bioactive Mucoadhesive Intestinal Calcitonin Delivery Systems

564

PlasACRYL HTP20: A New High Performance Easy-To-Use Coating System Additive

567

Preparation, Optimization and Characterization of Multiple Unit Microspheres Containing Kollidone SR

570

Rheological behavior of mucoadhesive liquid crystalline systems for buccal drug delivery

573

Solubility Enhancement of Ibuprofen Melt Extruded Solid Dispersions: In silico predictive Tools and in vitro Dissolution Profiles for Polymeric Carriers

576

Study of the Mechanical, Thermal and Rheological Properties of Ethyl Cellulose as a Film Coating Polymer

579

Taste Masking of Bitter APIs Through the Intermolecular Interactions Processed by Hot-Melt Extrusion

582

The method of fine dissolution control of tablets by direct compression in different test media using a novel pregelatinized starch, SwelstarTM MX-1

585

Transepithelial Transport in Calu-3 Cells Grown Under LCC and AIC Conditions: Impact of Mucus on Drug Permeability

707

The excipient, citric acid, does not increase permeability of isolated rat small intestinal epithelia

Bioactive Materials: Stem Cell and Regenerative Medicines 588

Bio-functionalized pH-sensitive carbonate apatite nanoparticles facilitated intracellular regulation of ES/iPS cells on E-Cad-Fc engineered matrix

Bioactive Materials: Translational Nanomedicine 651

Apoptotic synergy in colorectal cancer by triple combination with siRNA, paclitaxel and PEGlyated TNF-related apoptosis-inducing ligand (PEG-TRAIL)

654

In vivo Tissue Accumulation and Release of Platinum after local application of a novel Chitosan Hybrid-Gel targeting female reproductive organs

657

Nanostructured Microparticles that Mimic the Food Effect for Enhancing Oral Drug Absorption

C&DP: Consumer and Industrial Applications of Nanoparticle Technology 660

Comparative Studies on Nicergoline Amorphous and Crystalline nanoparticles

C&DP: Hydrogel Delivery Systems in Consumer Products 43

Mechanical characterization of mucoadhesive liquid crystalline systems for buccal drug delivery

C&DP: Nutraceuticals and Functional Foods 666

Effects of Gastrointestinal pH Conditions on the Stability of the β-lactoglobulin/Vitamin D3 Complex and on the Solubility of Vitamin D3

Veterinary: Protein and Vaccine Delivery 669

A Biomimetic approach to Active Self-healing Microencapsulation of Proteins in PLGA

672

An atomic force microscopy based method for biopharmaceutical stability determination

591

Immobilization of Catechol-Functionalized Polymer Nanoparticlesonto Ti Surfaces for Controlled BMP-2 Release

675

Combined, Sustained, and Bioactive VEGF and HGF Delivery From Low Viscosity Poly(5-ethylene ketal e-caprolactone-co-D,L-lactide)

594

Thermoreversible hydrogels as a Drug Release Platform in Degenerative Disc Disease

678

Demonstrating protein integrity within controlled release vaccine particles

681

Development of oral insulin nanoparticulate drug delivery system based on aromatic derivatives of chitosan

684

Folate Coupled Engineered Polymeric Nanoparticles as a Rationally Designed Carrier for Oral Delivery of Insulin

Bioactive Materials: Theranostics and Cancer Nanotechnologies 597

Cancer Targeted Imaging and Therapy by Stabilized HA Nanoparticles using UV Crosslinking

687

Misoprostol Inhibits In Vitro Intestinal Permeation Enhancing Effects of the Medium Chain Fatty Acid, Sodium Caprate (C10)

600

Development of Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy

690

603

Estradiol-PEG-Appended Multiwalled Carbon Nanotubes for Estrogen Receptor Targeted, Multimodal Delivery of Anticancer Agents

On/off Control of Enzyme Activity by Domain-specific Oligosaccharide Modification Preparation and characterization of insulin nanoparticles withchitosan and Arabic gum using ionic gelation method

606

Magnetoliposomes prepared by dual asymmetric centrifugation

609

Multicellular Tumor Spheroids for the Evaluation of Nanoparticle Intratumoral Transport

615

Protease Imaging System by Using Polyion-complex and Its Applicationto Prostate Cancer

693 696

Self-Assembled Nanogel Based on Hyaluronic Acid-Green Tea Catechin conjugates for Intracellular Protein Delivery

702

The role of the stabilising component cholesterol in eliciting a liposome or antigen depot-effect in DDA:TDB adjuvant delivery system

47

Poster Session III Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization 124

Solubility Enhancement of Atorvastatin Calcium by Solid Dispersions Using Hot Melt Extrusion

Bioactive Materials: Biomaterials

Bioactive Materials: DNA and RNAi Delivery 220

Biodegradable Polymer Nanoparticles Loaded siRNA/chitosan-gdeoxycholic acid Polyplexes for Prolonged Gene Silencing

223

Bio-reducible nanocarrier for therapeutic microRNA delivery to malignant breast cancer

226

Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

229

Co-delivery of siRNA and Doxorubicin into Cancer Cells by Cationic Liposomes based on pH-Sensitive Polymers

127

A Drug-Eluting Contact Lens

130

A Smart Gel Based Controlled Release of Insulin

133

Bacterial Nanocellulose as Active Wound Dressing for Controlled Release of Antiseptics

232

Controllable Release of Smart Polymer Nano-micelles for siRNA Delivery from Injectable Polyurethane Scaffolds In Vivo

136

Biodegradable monodisperse microspheres with sustained release of goserelin acetate for the treatment of prostate and breast cancer

235

Delivery of siRNA by PEG-alendronate-stabilized calcium phosphate nanoparticles

238

142

Chitosan Modified with Membrane-Permeable and Intracellular Reducible Molecules for Gene Delivery

Development of RAGE siRNA delivery system using bile acid-modified PEI for the treatment of myocardial infarction

241

145

Closed Loop Insulin Delivery in Diabetic Pigs using a Smart Biomaterial Device

Disulfide Reduction Considerations for Cationic Gene Delivery Systems

244

Efficient gene delivery using dendrimer type bioreducible polymer

148

Controlled Release of bFGF from Chemically-crosslinked Chitosan/Pluronic Hydrogel Containing Heparin

247

Enhanced Gene Transfection using Calcium Phosphate Co-precipitates and Low-Intensity Pulsed Ultrasound

151

Controlling the Release of A Naturally Occurring Antioxidant from N,O-carboxymethylchitosan and Methylcellulose Composite Films

250

Gene therapy for LPS/D-GalN-induced hepatitis by octaarginine peptide-modified nanoparticles

154

Design and characterization of biodegradable polymer-coated protein microparticles by spray drying method with a three-fluid nozzle

253

Hydrogel for Enhanced Intravesical Delivery of Lentiviral Vector Expressing WWOX in vivo

259

157

Disulfide bridging mono and di PEGylation of anti-VEGF Fab and Fab´

Knockdown of Survivin Protein Expression Using Liposomal siRNA

262

160

Effect of the mixture of herbal honey and water-soluble chitosan on the immunity reaction of mice infected with atopy

Mixed Carrier Made of Phospholipid-modified PEI and PEG-PE Improves Systemic Delivery of siRNA in tumors

265

163

Enzymatic synthesis of antibody-human serum albumin (mAb-HSA) conjugates for targeted drug delivery devices

Mutually Cross-linked siRNA/LPEI Nanogels for Efficient Gene Silencing

268

New pH Responsive Nanovesicular Vectors For Tumor Targeting

166

IGF-1 loaded monospheres for treating ischemic heart disease

274

169

In Vitro Behaviour of Composite Calcium Polyphosphate Disks Loaded with Vancomycin

pH-responsive lipids based on a molecular switchfor the improved delivery of nucleic acids

277

172

In Vivo Degradation and Tissue Response to Low Viscosity Poly(5-ethylene ketal e-caprolactone-co-D,L-lactide)

Protein-Polymer Core-Shell Conjugates for Controlled siRNA Delivery

283

175

Injectable modular hydrogels for controlled drug binding and delivery

Suppression of tumor growth by systemic delivery of anti-VEGF siRNA with cell-penetrating peptide-modified MPEG-PCL nanomicelles

178

Liposomal-based nano device with cell penetrating and pH-sensitive fusogenic peptides achieves efficient and highspeed transduction of antibody into living cells

286

Targeted Polymeric Gene Carriers to Deliver a Therapeutic sRAE-1 Plasmid to the Pancreatic Islets for the Prevention of Type 1 Diabetes

181

Matrix Metalloproteinase Responsive Genetically Engineered Silk-Elastinlike Protein Polymers

289

184

Nanoparticles prepared from chitosan-N-arginine and Poly(γglutamic acid)-taurine for oral delivery of antiangiogenic AE-941 protein

Therapeutic Silencing of Akt1 gene expression mediated by surface-immobilized Akt siRNA/ssPEI nanoparticles on coronary stent for Alleviating post-angioplasty restenosis

187

NVP-co-DMA-co-GMA Hydrogels with Cyclodextrins for Ocular Delivery of Carbonic Anhydrase Inhibitors

190

Paclitaxel conjugated polymeric micelle

193

Bioactive Materials: Drug Delivery to the Brain 292

Brain uptake of a fluorescent vector targeting the transferrin receptor: a novel application of in situ brain perfusion

Poly(ortho ester caprolactone): A New Acid-labile Injectable Semi-solid Material for Controlled Drug Delivery

298

In Vivo Internalization of Monoclonal Antibody Targeting the Murin Transferrin Receptor by Brain Capillary Endothelial Cells

196

Preliminary Characterization of Soft Degradable Biomaterial for Bone Scaffolding Applications

301

The effect of Fe3O4 nanoparticle-induced hyperthermia on the blood brain-barrier association and permeability

199

Reagentless Bidirectional Lateral Flow Bioactive Paper Sensors for Detection of Pesticides in Beverage and Food Samples

202

Rheological Properties of Commercially Available Viscoelastic Products Useful for Microparticle Suspension

205

Strategies to tailor protein release from biodegradable hydrophilic multi-block copolymer implants

208 211

48

Bioactive Materials: Intracellular Processes 307 Doxil® Modification with Octa-Arginine Conjugated Polymer for Enhanced Anticancer Activity 310

The effect of exopolysaccharides extrated from Botryosphaeria rhodina on bone tissue enginerring

ICAM-1-Targeted Nanocarriers are Endocytosed in the Gastrointestinal Tract of Mice

313

Thermoresponsive Block Copolymer-Based Biomaterials for Controlling Cellular Interactions

Mitochondrial delivery of bioactive molecules using Dual Function (DF)-MITO-Porter aimed at the mitochondrial genome

316

Silica Nanoparticle Surface Orientation Dictates the Mechanism of Uptake

Bioactive Materials: Nanomedicines

424

Tumor selective targeting and light induced cytotoxicity of Zn-protoporphyrin conjugated hydroxypropylmethacrylamide polymer (HPMA-ZnPP) micelle.

427

Ultrasound-responsive thrombus treatment with zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator

430

Well-defined prodrug micelles for non-steroidal anti-inflammatory drug delivery

708

Poly(amino acid)-modified polyethylenimine as gene delivery for cancer therapy

319

A Novel Method for the Manufacture of Protein-Coated Nanoparticles

322

A thermosensitive liposome prepared with a Cu2+ gradient demonstrates improved pharmacokinetics, drug delivery and antitumor efficacy

325

Apoptotic mechanisms of arsonoliposomes on medulloblastoma cell lines in normoxic and hypoxic conditions

331

Cellax, a docetaxel-carboxymethylcellulose nanoparticle, exhibits enhanced pharmacokinetic, biodistribution and metastatic cancer treatment efficacy profiles compared to Taxotere

334

Core crosslinked Pluronic micelles conjugated with doxorubicin and folic acid for cancer chemotherapy

433

337

Dectin-1 Mediated Delivery System Anti-Inflammatory Drug and Photo-Sensitizer to Immune Cells

A Novel High-Performance Thin-Layer Chromatography Method for the Quantitative Determination of Clofazimine

436

340

Design and Evaluation of Combination Polymeric Nanoparticles of Doxycycline and Rifampicin

Antiangiogenic Effect of Paclitaxel and Rapamycin Polymeric Micelles Individually and in Combination

439

346

Development of Nano-sized Polyion Complex Vesicles “PICsomes� as a Tool for Investigation of in vivo Nano-environment

Cancer Cell Spheroids as a Model to Study Sequential Chemotherapy Protocols

442

349

Doxorubicin and mitomycin co-loaded polymer lipid hybrid nanoparticle system increases efficacy against human breast cancer tumor in vivo

Combination Anticancer Nanopreparations of Novel Proapoptotic Drugs and TRAIL Ligand

451

Enhacement anticancer effect of Baicalein and Gemcitabine using multifunctional solid lipid nanoparticle on A549 cells line

Efficient overcoming of doxorubicin resistance in MCF-7/ADR cell line by substituting tariquidar with curcumin in nanoformulations for cancer therapy

454

In Situ Hydrogel for the Sustained Release of Anti-Cancer Drug

457

Nanomaterials Targeting the Extracellular Matrix-Modifying Enzyme Lysyl Oxidase (LOX) that Inhibit Mammary Tumor Growth

355

Engineering of Doxorubicin Gold Nanoparticles Using Folate Anchored Pegylated Poly(aspartic acid)

460

Novel pH Switchable Micelle/Polymerosome Vehicles For Controlled Release Of Anticancer Drugs

358

EPITHELIAL ACTIVE TARGETING BY LECTIN-NANOPARTICLES IN MURINE EXPERIMENTAL COLITIS

463

361

Evaluation of a novel targeting ligand to prepare mitochondriotropic liposomes with reduced cytotoxicity

Polyethylene Glycol-Phosphatidylethanolamine(PEG-PE)/Vitamin E Based Micelles for the Co-Delivery of Paclitaxel and Curcumin to Overcome Multi-Drug Resistance in Cancer

472

Systems Nanotechnology to Amplify Tumor Targeting

364

Formulation and Optimization of Chitosan Nanoparticles of BCS Class-III Drug Using Box-Behnken Design

478

367

HERBAL NANOFLAX: A New Paradigm for Epidermal Targeting and Alternative Treatment of Psoriasis

Tumor Vasculature Targeted Size Controlled PEGylated Liposomal Delivery System To Treat Chemotherapy Resistant Renal Cell Carcinoma

370

Investigation of Phase Behavior and Rheological Properties of PPG-5-CETETH-20 and Tetronics Surfactants Based Systems for Tetracycline Periodontal Formulations

376

Mixed Copolymer Nanoparticles for the Treatment of Drug Resistant Tumors: Formulation Development, Cytotoxicity and Pharmacokinetics

379

Molecular dynamics simulation of PEGylated bilayers as model for the drug delivery liposome surface: interaction with salt ions and effect of formulation

382

Multimeric Fullerenes for Rheumatoid Arthritis Therapy

385

Nanoparticle-assisted Boron Neutron Capture Therapy

388

Non-invasive in-vivo-monitoring of sustained nanosuspension release after s.c. application

391

Optimization of Nanoparticle Fabrication Using D-Optimal Statistical Mixture Experimental Design

394

Organic Nanotubes: Potential Nanocarriers for Doxorubicin

397

352

Bioactive Materials: Oncology and Tumor Targeting

Bioactive Materials: Oral Controlled Release 481

A New Hydrophilic Bioadhesive Matrix for Controlled Drug Release Generated in Direct Compression Tablets by Thermal Treatment: Mechanism Elucidation

484

A NOVEL SEMI EMPIRICAL APPROACH FOR EXTRUSION SPHERONIZATION BASED FORMULATIONS

487

Bioadhesion study of liquid crystalline systems on the tooth surface

493

Chrono - Delivery of Hydrocortisone Tablets Processed by Hot-Melt Extrusion (HME)

496

Comparative Evaluation of Tablet Properties prepared by new Super Fine Powder, Special Low Viscosity Grade of Hydroxypropyl Cellulose (HPC-SSL-SFP)

499

Design of Acyclovir Loaded Nanoparticles for Controlled Delivery System

PEGylation ofoxidized single-walled nanotubesfor sustained and pH-sensitive delivery ofdoxorubicin

502

Determining the microstructure of oral microemulsions containing Brij and Capmul.

400

pH-Responsive Nanogel-Caged Lipid-Containing Polymeric Vesicles for Effective Intracellular Drug Delivery

505

403

Poly(amino oxalate) particles: A new drug carrier for the treatment of acute liver failure

Development of Alternative Formulations of a Poorly Water-Soluble Drug, MK-0364, Using a Solid Dispersion Approach, Part I: Initial Screening Using a Solvent Casting Method

508

406

Polysaccharide Nanohydrogels as Drug Carriers

Development of Modified Release Formulations of Gabapentin for Relief of Symptoms accompanying the Female Menopause

409

Preparation, pharmacokinetics and tissue distribution of Lyophilized stealth Solid Lipid Nanoparticles Loaded Icariin

514

Dissolution Enhancement of Poorly Water-Soluble APIs Prepared

by Hot-Melt Extrusion (HME) using Hydrophilic Polymers

412

Self-assembled nanoparticles from acetylated anionic polysaccharide as chemotherapeutic drug carrier

517

415

Study of structural organization of cationic emulsion/oligonucleotide complexes by energy dispersive X-ray diffraction

EFAVIRENZ - POLYMER HOT MELT EXTRUSION SYSTEMS FOR DISSOLUTION ENHANCEMENT: PHYSICO-MECHANICAL CHARACERIZATION AND DRUG RELEASE STUDIES

520

418

Targeted Chemotherapy Using Electrostatic Charge Conversion of Tumor-identifying Polypeptides

Effect of Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug

421

The Effect of PEG-grafted-PLA Nanoparticles Loaded with Famotidine on Apical Efflux Using CaCo-2 Cell Monolayer.

523

Evaluating an alternative to fluid bed technology for drug layering and for applying functional coats onto pellets

526

Evaluation of dissolution and permeation by verted gut sac technique of solid dispersion zidovudine

Poster Session III continued

49

Poster Session III—Bioactive Materials: Oral Controlled Release continued 529

Extended Release Oral Formulation for the Treatment of Hypothyroidism

535

Improving drug safety: Compritol® 888 ATO matrix tablets deliver consistent sustained drug release in hydro-alcoholic media and when broken.

538

Incorporating Polymers into Softgel Capsule Fills for Extended Release

541

In-situ solubility measurements of ionizable drugs and precipitation behaviour in the presence and absence of Plasdone polymer crystallisation inhibitors

Bioactive Materials: Transdermal Drug Delivery 619

A Novel Lipid Carrier for the Delivery of Local Anesthetic Drug

622

Anti-Wrinkle Treatment by a Dissolving Microneedle Patch

625

Development of Terbinafine Solid Lipid Nanoparticles for Topical Delivery System

628

Effect of Terpene-Transcutol® Mixtures on the Enhanced Topical Delivery of Naftifine Hydrochloride

631

Enhanced topical delivery of skin rejuvenation agents by fractional radiofrequency microporation

634

Formulation and characterization of controlled release benzoyl peroxide microsponges

544

Investigation of barrier film changes during dissolution testing to rationalize controlled release pellet formulations

637

In vitro permeation of donepezil hydrochloride from transdermal films

547

IPEC-Americas New Excipient Safety Evaluation Procedure

640

Liposomal formulations for (+)-catechin topical application

550

Modification, modeling and characterization of an interpolyelectrolyte complex as a hydrogel for gastroretention

643

Novel PEG-Zein Nanomicelles for Topical Delivery of Retinol

646

Smart micellar systems for targeted cutaneous drug delivery

553

Mucoadhesive and swelling properties of free films of high amylose-pectin mixtures modified by cross-linking or retrogradation

649

Topical Delivery of Curcumin using Ethosomes

556

Oral Disintegration Tablet for Carbamazepine Solid Dispersion

562

Particle formation process of nano-aggregated microparticles

652

565

Prediction of Release Profiles of Extended Release Indomethacin Capsule Using Multiple Regression Analysis

Doxorubicin-incorporated bionanocapsule enhances the radiotherapeutic efficacy without cardiotoxicity

655

571

Robustness of Intermediate Molecular Weight HPMC Controlled Release Polymers in Biorelevant Dissolution Test

Kinetic Targeting of pegylated liposomal Doxorubicin: Plasmapheresis reduces Toxicity of Anticancer Chemotherapy (CARLTrial)

574

Solubility Enhancement of Simvastatin with use of Novel Polymeric Solubilizer Soluplus®

577

Supported Bilayer on a Nanopatterned Membrane as Model PAMPA Membranes

580

Terpolymer Solubilizer - Modeling and Experiment Comparison

583

The Utility of Wet Granulation to Produce Compritol 888 ATO Matrix Tablets for the Sustained Release of Diclofenac Sodium

Bioactive Materials: Stem Cell and Regenerative Medicines 592

Nano-pillar array for differentiation of human mesenchymal stem cells

Bioactive Materials: Theranostics and Cancer Nanotechnologies

Bioactive Materials: Translational Nanomedicine

C&DP: Consumer and Industrial Applications of Nanoparticle Technology 661

Lutein nanosuspension with improved skin penetration in human

C&DP: Hydrogel Delivery Systems in Consumer Products 664

In Vitro Characterization Studies of Bioadhesive Ketoprofen Gels for Buccal Administration

C&DP: Nutraceuticals and Functional Foods 667

Influence of folic acid/protein nanocomplexes on the photodegradation of folic acid

595

Alternative sonochemical method for the synthesis of folate-modified human serum albumin (HSA) nanocapsules for targeted drug delivery

670

598

Cancer-targeted Theranostic System Based on Low Density Lipoprotein-mimetic Solid Lipid Nanoparticles Incorporating Paclitaxel and Iron Oxide Nanocrystals

Activation of splenic marginal zone B cell by PEGylated liposome with lower dose: triggering transport of antigen-containing second dose PEGylated liposome from marginal zone to follicle

673

601

Disulfide-Cross-linked Polymer Micelles as a Carrier of Docetaxel: In Vivo Biodistribution and Antitumor Efficacy

Antiresorptive Drug Delivery Strategy using Single Chain Fraction Variable as an Osteoclast Targeting Platform

676

604

Facile Preparation of Enzyme-triggered Photodynamic Complex for Tumor Diagnosis and Photodynamic Therapy

Comparing liposome manufacturing techniques for the delivery of sub-unit antigens

679

610

Nanoparticle Mediated Thermoablation in Spinal Column Tumors in a Rat Model of Metastatic Breast Cancer

Designing Hydrogel-based Scaffolds for Carrying and Retaining Encapsulated Therapeutic Cells

682

613

Non-viral Delivery of siRNA by a Combination of Novel Bioreducible Polymer, FocusedUltrasound, and Microbubbles for Prostate Cancer Treatment

Evaluation of Bone-Targeting Salmon Calcitonin Analogues in Rats Developing Osteoporosis and Adjuvant Arthritis

688

Nanoscaled buffering zone of charged (PLGA)n-b-bPEI micelles in acidic microclimate for potential protein delivery application

Synthesis and in vitro Properties of Image-Guided and Actively Tumor-Targeted Drug Carriers

691

PEGylated TNF-related apoptosis-inducing ligand (TRAIL) suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

694

Protective effects of cell transduction and retention-enhancing metallothionein fusion proteins against hyperglycemia and hypoxia in H9c2 cardiomyocytes

697

Self-Encapsulating PLGA Microspheres for Targeting and Delivery of Vaccine Antigens to APCs

703

THERMO-SENSITIVE POLYELECTROLYTE NANOPARTICLES FOR PROTEIN DELIVERY

616

50

Veterinary: Protein and Vaccine Delivery

Join CRS in the Ultimate Global Gathering Place

Hawaii The 40th Annual Meeting & Exposition of the Controlled Release Society July 21–24, 2013 Hawaii Convention Center Honolulu, Hawaii, U.S.A. Emerging Challenges for Global Delivery The 2013 CRS Annual Meeting & Exposition in Hawaii will create the perfect opportunity to access the latest in delivery science worldwide.

This unique location allows for greater connections with researchers throughout the Pacific Rim. A meeting you will not want to miss—mark your calendars now to join CRS in spectacular Honolulu, Hawaii!

Abstract Submissions Open November 2012

www.controlledreleasesociety.org/meeting 51

Courtesy of the Hawaii Convention Center / David Cornwell.

Experience the CRS Exposition!

Come to the Exposition Hall for discovery, solutions, and opportunities. Located on Floor 4, Exposition Hall 400A/B/C is the place for the business of delivery science and profitable collaboration.

When is the Exposition open?

When and how do I redeem my beverage tickets?

On Sunday evening, the exposition kicks off with a welcome reception designed for networking among colleagues, old and new. Booths are again open for visitors during dedicated exhibit hours on Monday and Tuesday, see page 3.

With thanks to new Café Sponsors, you can use your three tickets from your registration materials for a beverage from the Café during poster sessions when authors are present (see sessions, page 4). Outside of these times, refreshments are available for purchase.

What else is in the Exposition Hall?

This is the central hub for poster viewing, program breaks, networking, refreshments, and a CRS Connect seating area for meeting up with colleagues.

Who will I find at the Expo?

Knowledgeable representatives from leading companies that provide products, services, and technologies for the delivery science market.

Exhibitors of the 39th Annual Meeting & Exposition of CRS The following descriptions, supplied by the exhibiting companies as of May 21, 2012, provide product, service, and contact information. Please see the Program Addendum for additional exhibitor information.

S 101

S

504

330

52

– Sponsor

CS

– Café Sponsor

3M Drug Delivery Systems, U.S.A., Tel: 1.800.643.8086, www.3m.com/dds. 3M Drug Delivery Systems is a global leader in transdermal and inhalation drug delivery development and components. Between drug discovery and commercialization, we offer innovative and proven technology, product development services, global regulatory expertise, commercial manufacturing, and a broad range of customizable system components. Our expertise increases your opportunity for success.

Adhesives Research, U.S.A., Tel: +1.717.235.7979, www:adhesivesresearch.com. Adhesives Research/ARx, LLC is a leading developer/manufacturer of custom adhesives, dissolvable films, laminates, engineered fiber technologies, anticounterfeiting On-Dose covert markers, and drug delivery systems for the healthcare industry. We specialize in formulation/process development and commercial manufacture for unique transdermal and oral/mucosal drug delivery systems.

FDA-registered site, ISO 9001 & 13485 certified, DEA license.

Advanced Polymer Materials Inc, Canada, Tel: +1.514.683.8488, www.apmpolymers.com. We are a Canada-based manufacturer with R&D capability, producing innovative, unique biodegradable and biocompatible polymers and block copolymers (mPEGs, functional PEGs, multi-arm PEGs, and functional PEG/PLA, PLGA, and PCL) to fill the need for scientific advancement in pharmacy, biomaterials, and functional nanoparticles. We do custom syntheses and contract research.

303 Agilent, U.S.A., Tel: +1.302.633.8000, www.agilent. com. Agilent is the new standard in dissolution!

S Building off the Varian and VanKel legacies for marketing-leading dissolution instrumentation, Agilent now offers apparatus, sampling systems, and analytical instruments for HPLC and UV-Vis. Plus Agilent provides a comprehensive services portfolio to ensure the method development support, regulatory guidance and laboratory expertise you require.

502 Akina, Inc., U.S.A., Tel: +1.765.464.0501, www.polyscitech.com. Research products available include biodegradable block and specialty copolymers (polyvivo), fluorescent dyes (FlammaFluor), specialty chitosan variations (Kitopure), and release media (polyvitro). Custom synthesis to match your specification and contract analysis services are also available. Primary focus is implantables and drug delivery systems. Technologies available for licensing include aquagel, nanodrugsystems, and frosta.

113

Alkermes Contract Pharma Services, Ireland, Tel: +353 906495000, www.alkermes.com/contract.

Alkermes Contract Pharma Services provides solid oral dosage product development, scale-up, and manufacturing services as well as sterile fill finish capabilities to the pharmaceutical market and is part of Alkermes plc. A blue chip client list of partners avail of our 40+ years’ experience and expertise in the service business.

135

413

CS

209

S

204

318

333

American Pharmaceutical Review, U.S.A., Phone: +1.317.816.8787, www.americanpharmaceuticalreview. com. American Pharmaceutical Review is the leading review journal for business and technology in the pharmaceutical industry throughout North America.

Each issue offers unbiased editorial coverage of the latest developments in: drug delivery, information technology, research & development, analytical development and control, equipment and facility manufacturing and regulatory affairs.

309

Apricus Bio/NexMed USA, U.S.A., Tel: +1.858.222.8041, www.apricusbio.com. Apricus Bio is a San Diego–based revenue-generating pharmaceutical company, with commercial products and a broad pipeline. Revenues and growth are driven from the sales of the company’s commercial products and through out-licensing of its NexACT® technology. For more information on NexACT multi-route drug delivery technology, please see www.apricusbio.com/ nexact_platform.html.

418 & Banner Pharmacaps, U.S.A., Tel: +1.336.812.8700, www.banpharm.com. Banner is a global drug delivery 319 and specialty pharmaceutical company committed to S researching, developing, and producing unique oral dosage forms. We offer considerable expertise in CS gelatin-based drug delivery systems: Versatrol™ controlled release softgels; EnteriCare™ enteric softgels; Chewels™ chewable softgels; LiquiSoft™ liquid-filled softgels; Soflet® gelcaps; and Solvatrol™ solubility systems.

Aptalis Pharmaceutical Technologies, U.S.A., Tel: +1.908.927.9600, www.AptalisPharmaTech.com.

Aptalis Pharmaceutical Technologies (formerly Eurand Pharmaceutical Technologies) develops and manufactures enhanced oral pharmaceutical products based on its broad range of proprietary technologies, which include bioavailability enhancement of poorly soluble drugs, custom release profiles, and taste-masking formulations for a variety of dosage forms including orally disintegrating tablets. Visit us at Booth #209.

200 & BASF, U.S.A., 1.800.443.0627, www.pharma202 ingredients.basf.com. BASF offers a range of innovative excipients, including Kollicoat color coating systems, Soluplus, and Kollicoat Smartseal 30 D, a new excipient for taste masking and moisture protection and the featured product at this year’s conference. BASF also supplies active ingredients and provides exclusive custom synthesis services.

Asahi Kasei America, Inc., U.S.A., Tel: +1.212.371.9900, ext. 222, www.ceolus.com/en/. Asahi Kasei is a global excipient manufacturer specializing in established as well as specialty grades of microcrystalline cellulose, including the highly compactible Ceolus™ KG and UF grades and MCC spheres, tradenamed Celpheres™. Our Swelstar™ pregelatinized starch products include a unique controlled release gel matrix excipient, MX-1. Visit us at www.ceolus.com/en/.

Avanti Polar Lipids, U.S.A., Tel: 1.800.227.0651, www. avantilipids.com. Avanti Polar Lipids, with an unparalleled reputation for purity, is clearly established as a world leader in the production of phospholipids, sphingolipids, and sterols. Exciting new products for the research chemist and cGMP lipids for pharmaceutical production. Recent developments include adjuvants, glycosylated sphingolipids, new fluorescent and deuterated lipids, plus analytical services.

AVESTIN, Inc., Canada, Tel: +1.613.736.0019, www.avestin.com. AVESTIN manufactures EmulsiFlex high pressure homogenizers and LiposoFast liposome extruders in Ottawa, Canada. With instruments for laboratory through to production scale, AVESTIN offers solutions for the production of nanoparticles, submicron emulsions, liposomes, and cell lysis. Utilizing a unique design free of any “o”-rings or gaskets, standard equipment operates to 2,000 bar/30,000 psi.

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AVEVA Drug Delivery Systems Inc., U.S.A., Tel: +1.954.430.3340, www.AvevaDDS.com. AVEVA is a global leader in transdermal drug delivery. The company has an extensive history of providing pharmaceutical partners with fully integrated, controlled release transdermal products that fulfill unmet market needs or supply high-quality, affordable brand equivalents.

AVEVA offers a full range of research, development, and manufacturing capabilities for transdermal pharmaceuticals.

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Bio-Images Group Ltd., United Kingdom, Tel: +44 1415528791, www.bio-imagesgroup.com. We can help validate product claims and demonstrate formulation superiority using our expertise in scintigraphic imaging combined with other investigational approaches such as PK sampling, pH telemetry, and the IntelliCap remote drug delivery capsule. Our formulation development experts specialise in “rescue formulation”—delivering innovative solutions where other attempts have failed.

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BUCHI Corporation, U.S.A., Tel: +1.877-MYBUCHI, www.mybuchi.com. For over 50 years, Buchi has been known as the market leader of lab instruments based on evaporation and vacuum technologies. In addition, BUCHI Corporation is the North American provider of flash chromatography, NIR spectroscopy instruments, Kjeldahl and solvent extraction instrumentation, spray dryers, and melting point apparatus.

300 & Catalent Pharma Solutions, U.S.A., Tel: 201 +1.732.537.6200, www.catalent.com. From optimizing release profiles to target drug delivery, we are the catalyst for your success. We have the most innovative technologies, including OptiMelt™ hot melt extrusion, OSDrC® OptiDose™ optimized dosing, and Zydis® fast-dissolve tablets, to enhance your products and solve your challenges. Catalent. More products. Better treatments. Reliably supplied.

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Celanese EVA Performance Polymers, U.S.A., Tel: +1.972.443.3738, www.vitaldose.com. Celanese EVA Performance Polymers has provided EVA (ethylene vinyl acetate) technology for medical and pharma applications for years. We work with you to meet your application performance targets and conformance with regulatory requirements. EVA excipients offer customizable release properties, favorable biocompatibility profile, and suitability for implant applications.

106 & Colorcon, Inc., U.S.A., Tel: +1.215.699.7733, 108 www.colorcon.com. Colorcon is a world leader in the development, supply, and technical support of S formulated film coating systems, modified release technologies, and functional excipients for the pharmaceutical industry. Our best-in-class products and technologies are complemented by our value-added services, which support all phases of solid oral dose design and development.

124 Contract Pharma, U.S.A., Tel: +1.201.880.2229, www.contractpharma.com. Contract Pharma’s publication, Contract Pharma Direct Newsletter, and website devote more coverage to contract services and outsourcing than any other source. Contract Pharma provides readers with current news, business trends, and commentary and viewpoints from industry leaders. This editorial formula combined with value-added services make Contract Pharma the industry leader.

212 CordenPharma, Switzerland, Tel: +1.617.909.5176, www.cordenpharma.com. CordenPharma Switzerland, (formerly Genzyme Pharmaceuticals) is one of multiple cGMP facilities within CordenPharma International, a full-service CMO for a global market. As a reliable supplier of custom and readily available synthesized materials, CordenPharma Switzerland provides customers a legacy of expertise focused on lipids, peptides, lipo-peptides/conjugates, and pseudoproline dipeptides.

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Covaris Inc., U.S.A., Tel: +1.781.932.3959, www.covarisinc.com. Covaris designs and manufactures equipment based on Adaptive Focused Acoustics ™ (AFA) technology, scalable from 100ul through pilot scale sample volumes, non-contact, and isothermally.

AFA has enabled breakthrough performance in a number of Formulation processes, including dissolution, micronization, nano-suspensions, sono-crystallization, and liposome formation.

Croda Inc., U.S.A., Tel: +1.732.417.0800, www.croda. com/healthcare. Croda offers a complete range of products including high-purity multicompendial solvents, solubilizers, and surfactants for parenteral, oral, ophthalmic, and topical formulations. Featured products include Super Refined® ingredients: castor and other oils, oleic acid, oleyl alcohol, PEGs, polysorbates, propylene glycol, dimethyl isosorbide, medical grade lanolins, poloxamers, and omega-3 fatty acid concentrates.

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Delta Industrial Services Inc., U.S.A., Tel: +1.763.755.7744, www.deltamodtech.com. Delta Industrial is a leader in web converting and packaging innovation. Delta is dedicated to providing flexible automation solutions to converters and manufacturers worldwide. Delta offers engineering expertise in developing and building manufacturing solutions for diagnostics, transdermals, electrodes, wound care, and a variety of complex medical and pharmaceutical products.

518A Dissolution Technologies, U.S.A., Tel: +1.302.235.0621, www.dissolutiontech.com. Dissolution Technologies is a peer-reviewed, indexed quarterly journal reporting current information and scientific articles on dissolution testing. Books related to dissolution topics are available for sale on the searchable website, www.dissolutiontech.com. The website contains all back and current issues, and these articles are available for free as a PDF download.

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Distek, Inc., U.S.A., Tel: +1.732.422.7585, www.distekinc.com. Distek is a manufacturer of pharmaceutical laboratory instruments, specializing in dissolution products and services. Distek also provides solutions for fiber optic UV, media preparation, friability, disintegration, and validation services. Visit Booth #432 to see the bathless symphony 7100, the ActiPix SDI300 surface dissolution imaging system, and the Opt-Diss 405 Fiber Optic UV system.

110 & Dow Water & Process Solutions, U.S.A., Tel: 112 1.800.447.4369, www.dowwaterandprocess.com. The global leader in sustainable separation and purification technology, Dow Water & Process Solutions is making a clear impact in the world. DW&PS offers a broad portfolio of ion exchange resins, RO & UF membranes, and EDI products in a number of major application areas. Visit www.dowwaterandprocess.com for more information.

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Drug Development & Delivery, U.S.A., Tel: +1.973.299.1200, www.drug-dev.com. Drug Development & Delivery is a print and digital publication exclusively committed to advancing the applied science, technology, and related business practices of pharmaceutical and biological drug development, including: • Drug Delivery Technologies • Controlled Release • Formulation Development • Bioavailability • Medical Devices/Combination products • Contract Services • Solubility Enhancement • Life-cycle management • Regulatory issues

306 & DURECT Corporation, U.S.A., Tel: +1.408.777.1417, www.durect.com. DURECT Corporation is a specialty 308 pharmaceutical company developing therapeutics based CS on its proprietary delivery technologies. These technologies include the injectable depot system, ORADUR® oral sustained-release platform, TRANSDUR® transdermal technology, and DURIN biodegradable implant. DURECT also partners with other companies to develop and commercialize enhanced pharmaceutical products based on its technologies.

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Elsevier, U.S.A.; Tel: +1.212.989.5800, Website: www.elsevier.com. Elsevier publishes the Journal of Controlled Release, the official journal of the Controlled Release Society and the Japanese Society of Drug Delivery System. Elsevier is the leading publisher dedicated to providing authors the latest articles, tools, and resources within pharmaceutical sciences.

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EMD Millipore, U.S.A., www.emdmillipore.com.

EMD Millipore is the life science division of Merck KGaA. We provide excipients, ODT technology, drug delivery compounds, and chemicals to support all stages of drug manufacturing from research to industrial-scale production and quality control. Our products meet the highest purity standards with extensive documentation and services assuring regulatory compliance.

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Emeryville Pharmaceutical Services, U.S.A., Tel: +1.510.899.8814, www.emerypharmaservices.com.

Emeryville Pharmaceutical Services offers NMR (1D, 2D, heteronuclear), LCMS, and microbiology (MIC, MBC, biofilm models, cytotoxicity, resistance passaging, and microscopy) analytical services. Please visit our website at www.emerypharmaservices.com for a full description of our offered services as well as examples of our work.

100 & Evonik Degussa, U.S.A., Tel: +1.732.981.5383, 102 www.pharma-polymers.com. Evonik Pharma Polymers manufactures EUDRAGIT® controlled release polymers and PLGA polymers for injectable delivery (RESOMER® and Lakeshore™ Biomaterial). Evonik offers oral and injectable extended release formulation development and manufacturing of clinical supplies.

Evonik has expertise in bioavailability enhancement, including solutions for BCS Class III/IV compounds, microspheres (FormEZE®), and injectable implants.

214 FEI, U.S.A., Tel: +1.503.726.7500, www.fei.com.

FEI electron microscopy solutions are being used

today in research laboratories around the world: to explore the in vivo molecular mechanisms of disease;

to visualize the 3D architecture of tissues and cells; to unambiguously determine the conformation of flexible protein structures and complexes. FEI. Explore.

Discover. Resolve.

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Fluid Imaging Technologies, U.S.A., Tel: +1.207.846.6100, www.fluidimaging.com. The FlowCAMÒ imaging particle analysis system rapidly detects, images, and characterizes particles in parenteral and other formulations. Sophisticated pattern recognition software automatically quantifies particles and differentiates microcapsules from contaminants or protein aggregates from silicone oil droplets and other particulates. The new, smaller, single application FlowCAM PV Series is now available!

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Freund-Vector Corporation, U.S.A., Tel: +1.319.377.8263, www.freund-vector.com. FreundVector Corporation is a full-service manufacturer of solid dosage processing equipment for the coating, granulating, and drying of powders, granules, beads, and tablets for the pharmaceutical and healthcare industries. Product lines include fluid bed granulators/ coaters/dryers, high shear granulators, roll compactors, tablet film pan coaters, and automated process control systems.

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Gateway Analytical, U.S.A., Tel: +1.724.443.1900, www.gatewayanalytical.com. Gateway Analytical provides cGMP- and ISO-compliant analytical testing and consulting services to support controlled release product development. Rely on our 15 years of experience in pharmaceutical and materials science testing, including content uniformity and layer thickness analysis, particle characterization, polymorph analysis, and unknown material identification.

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Gattefossé USA, U.S.A., Tel: +1.201.265.4800, www.gattefosse.com. Gattefossé is a global provider of excipients and innovative formulation technologies for enhancing drug delivery. We offer unique solutions for solubilization, permeation enhancement, sustained release, taste masking, and more. Our products are referenced as key components of many currently marketed oral, topical, vaginal, and rectal dosage forms.

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Gaylord Chemical Company, U.S.A., Tel: +1.985.649.5464, www.gaylordchemical.com. Gaylord produces Procipient® (dimethyl sulfoxide USP, PhEur) a high-purity product manufactured according to cGMP (ICH Q7A) guidelines. It is supported by a Type II Drug Master File, making it the appropriate DMSO for use in delivery systems and medical devices or as an API in pharmaceutical dosage forms.

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119 Giltech, United Kingdom, Tel: +44 7852 926 464, www.giltech.biz. Giltech has created a unique portfolio of proprietary biodegradable and controlled release technologies. Our exhibit will specifically introduce Corglaes®, a technology for the controlled, sustained release of metal ions. We have a proven track record of partnering with companies to support innovative product development based on bespoke formulations of Corglaes®.

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Glatt Pharmaceutical Service, U.S.A., Tel: +1.201.825.8700, www.glatt.com. Glatt Pharmaceutical Services provides solvent and aqueous based formulation/process development and commercial-scale cGMP manufacturing for oral solids (including controlled substances). Core technologies include highshear and fluid bed granulating/drying, tablet compression, pan coating, Wurster HS® drug layering/ coating, CPS Technology® direct pelletizing, encapsulation, oven tray drying/curing, blending, milling, and sieving.

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Grünenthal GmbH, Germany, Tel: +49 241 5690, www.grunenthal.com. Grünenthal is an independent, family owned international research-based pharmaceutical company with a unique position in pain. Grünenthal’s innovative tamper-resistant formulation technology INTAC™ raises hurdles against abuse/inadvertent misuse of tablets.

INTAC™—the leading technology for tamperresistant opioid products—is established at commercial manufacturing scale and featured in FDA-approved products (marketed by U.S. partners).

Hanson Research, U.S.A., Tel: 1.800.821.8165 or +1.818.882.7266, www.hansonresearch.com. Hanson Research is a world leader in dissolution test technology for the pharmaceutical industry. Founded in California in 1951, we design, manufacture, install, and service equipment for pharmaceutical research and quality control. We take pride in our 9001:2008 quality program.

205 Henkel, U.S.A., Tel: +1.908.685.5317, www.henkelna. com/transdermal. Henkel is the global leader in acrylic polymers for transdermal drug delivery, with more than 35 years’ experience in acrylic pressure-sensitive adhesives, expert technical service, complete regulatory support, and manufacturing capability in North America and Europe. Henkel has the experience, resources, and expertise to make your transdermal project a success.

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Hovione LLC, U.S.A., Tel: +1.609.918.2600, www.hovione.com. Hovione is an international company with over 50 years’ experience in API development and compliant manufacture. With four FDA-inspected sites in the United States, China, Ireland, and Portugal, the company also offers integrated inhalation solutions spanning API particle engineering and formulation development services through to our proprietary DPI devices and the unit dose.

InGell Labs B.V., The Netherlands, Tel: +31 6136 020 12, www.ingellpharma.com. InGell Labs develops injectable bioerodable drug depots. Pharma customers provide the actives, we formulate and fine-tune, they then take the controlled release formulation through clinical evaluations. The patent-protected InGell polymer platform can be sourced under cGMP; using 25-31G needles for injection, the gelled formulations can release proteins-peptides-SMDs up to months.

InnoCore Pharmaceuticals, The Netherlands, Tel: +31 (0)50 5753100, www.innocorepharma.com. InnoCore Pharmaceuticals is a biopharmaceutical drug delivery company specializing in the development of longacting and minimally invasive drug delivery products for the treatment of chronic diseases. Our proprietary technologies include the biodegradable SynBiosys® drug delivery platform, injectable solid implants, monodisperse microspheres, medical device coatings, injectable hydrogels, and protein stabilization excipients.

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KORSCH America Inc., U.S.A., Tel: +1.508.238.9080, www.korschamerica.com. KORSCH is the global leader in tablet compression technology, offering the most innovative product line for development, scale-up, automated production, and wash-in-place/high-containment applications.

KORSCH offers single-layer, bi-layer, tri-layer, fourlayer, five-layer, and tablet-in-tablet technology.

306 & LACTEL Absorbable Polymers/DURECT 308 Corporation, U.S.A., Tel: +1.877.705.8072,

www.absorbables.com. Come talk to a polymer expert CS at Booth #306/308 about our stock and custom biodegradable polymers for drug delivery. As the oldest commercial source of biodegradable polymers in the United States, DURECT draws upon decades of experience in polymer chemistry, product development, and GMP manufacturing.

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Lipoid LLC, U.S.A., Tel: +1.973.735.2692, www. lipoid.com. Lipoid is a manufacturer of pharmaceutical grade phospholipids from three cGMP facilities based in Germany. In addition to synthetic phospholipids used in controlled release, Lipoid produces parenteral, topical, and oral grade egg, soy, and rapeseed lecithin.

Lipoid has over 40 Drug Master Files for excipients on file with the FDA. LTS Lohmann Therapy Systems, U.S.A./Germany, Tel: +1.973.575.5170, www.lts-corp.com. LTS is one of the worldwide leading companies in creating successful products from active ingredients in innovative dosage forms, and is the market leader in the development and manufacture of transdermal therapeutic systems and oral thin films. LTS provides what drug manufacturers expect from an experienced and reliable outsourcing partner.

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Lubrizol Advanced Materials, Inc., U.S.A., Tel: +1.216.447.5000, www.pharma.lubrizol.com. Lubrizol Advanced Materials is a global producer of highperformance pharmaceutical ingredients, including Carbopol® polymers, Pemulen™ polymers, and Noveon® polycarbophil. Carbopol® polymers are highly efficient gel-matrix formers for controlling drug release in oral solid dosage forms and provide thickening and suspending properties in semisolid and liquid formulations.

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Medimetrics Personalized Drug Delivery, Inc.,U.S.A., Tel: +1.617.840.8564, www.medimetrics. com. Medimetrics Personalized Drug Delivery Inc. will feature the IntelliCap™ technology for the development of orally active substances. The IntelliCap is an ingestible electronically controlled capsule that can release a payload of active substance at a selected pulsed or burst rate throughout the entire GI tract.

Stop by our booth.

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Michelson Prize & Grants, U.S.A., Tel: +1.310.574.5780, michelson.foundanimals.org. Could your controlled release technology win you $25 million?

The Michelson Prize & Grants seeks controlled release technologies to lengthen the duration of contraceptives for cats and dogs. Grants are offered to pursue development of a permanent, nonsurgical sterilant for cats and dogs, and $25 million will be awarded for the product.

218 NanoSight, U.S.A., Tel: +1.614.888.0023, www.nanosight.com. NanoSight manufactures instruments for counting, sizing, and visualizing nanoparticles from 10 nm to 2.0 µm. Measuring exosomes, protein aggregates, and virus particles are a few common applications. Fluorescently labeled nanoparticles can be measured as small as 20 nm. Size and concentration measurements along with the ability to visualize the nanoparticles.

430 Microfluidics, U.S.A., Tel: +1.617.969.5452,

www.microfluidicscorp.com. Microfluidics is a manufacturer of fluid material processors for unparalleled cell disruption, microencapsulation, microemulsions, dispersions, and deagglomeration.

Microfluidizer processors provide consistent and reproducible formulations, as 100% of your product is exposed to identical processing conditions every time.

Scale-up is guaranteed, providing seamless transition from laboratory through production.

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National Experimental Biology Centre—INRS, Canada, Tel: +1.450.687.5010, ext. 4396, www.iaf.inrs. ca. NEBC is an organization dedicated to animal experimentation. We offer a wide range of services including pharmacokinetic, exploratory toxicity, and drug efficacy studies (vaccine/adjuvant, oncology, inflammation, infectious diseases, dermatology, diabetes, and autoimmune diseases). We have expertise with primate, dog, ferret, pig, sheep, goat, poultry, shrew, rabbit, and rodent.

232A Molecular Pharmaceutics / ACS Publications, U.S.A., Tel: +1.202.872.4600, www. pubs.acs.org/ molecularpharmaceutics. Molecular Pharmaceutics publishes high-quality research, advancing the understanding of pharmaceutics at the molecular level while providing a forum for research among the fields of physical and pharmaceutical chemistry, biochemistry, molecular and cell biology, and polymer and materials science focused on drug delivery.

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National Institute of Biomedical Imaging and Bioengineering, U.S.A., Tel: +1.301.496.9208, www.nibib.nih.gov. The National Institute of Biomedical Imaging and Bioengineering (NIBIB) leads the development and accelerates the application of emerging and breakthrough biomedical technologies in order to improve human health. The institute is committed to integrating the engineering and physical sciences with the life sciences to advance basic research and medical care.

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Mylan Technologies Inc., U.S.A., Tel: +1.802.527.9265, www.mylantech.com. Mylan Technologies Inc. (MTI) is a leading producer of transdermal drug delivery systems. From design to commercial production, our manufacturing capabilities include formulation, coating, laminating, film extrusion, die cutting, and packaging. These capabilities allow production of high-quality transdermal drug delivery systems and precision components for medical device applications.

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NAL Pharma Ltd., U.S.A., Tel: +1.732.329.1388, www.NALpharma.com. NAL Pharmaceuticals is a proprietary drug developer that applies NAL’s unique Bio-FX, Bio-CR, and Bio-D3 DDS technologies to develop novel delivery systems, including orally dissolving film (ODF) for fast-onset intra-oral absorption and site-targeted transdermal patch systems with up to seven days of sustained drug delivery.

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NanoImaging Services, U.S.A., Tel: +1.888.675.8261, www.nanoimagingservices.com. NanoImaging Services, Inc. is a CRO specializing in nanoparticle imaging and analysis services used in formulation development and manufacturing of liposomes, micelles, viruses, VLPs, vaccines, proteins, and antibodies. The analysis provides direct visualization and quantification of size, shape, morphology, and internal structure as well as rapid turnaround of digital final reports.

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Nisso America Inc., U.S.A., Tel: +1.212.490.0350, www.nissoexcipients.com. Nisso America Inc. is a wholly owned subsidiary of Nippon Soda Co., Ltd. (Tokyo, Japan), manufacturers of Nisso HPC (hydroxypropyl cellulose). Nisso HPC is available in a wide range of viscosities and particle sizes and is USP/ NF, EP, and JP compliant.

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NOF America Corporation, U.S.A., Tel: +1.914.681.9790, www.dds-drug.com. NOF is a leader in drug delivery system products in pharmaceuticals.

We supply high-quality materials for the pharmaceutical market, such as activated PEG derivatives for PEGylation, phospholipids for liposome formulation, cationic lipids, Polysorbate 80, and solubilizer for hydrophobic drugs. NOF offers from reagent grade to clinical- and commercial-scale cGMP production.

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Northern Lipids Inc., Canada, Tel: +1.604.222.2548, www.northernlipids.com. NLI is a contract manufacturing organization that also specializes in offering services for preclinical and clinical development of lipid-based pharmaceutical formulations such as liposomes, emulsions, and micelles. We provide LIPEXÔ brand extruders, customized formulation development, scale-up, and analytical services from R&D through to commercialization.

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Novozymes Biopharma, U.K., Tel: +1.617.401.2500, www.biopharma.novozymes.com. Novozymes Biopharma develops and manufactures high-quality, animal-free, and regulatory-compliant recombinant ingredients and technologies to provide pharmaceutical and medical device manufacturers the knowledge-based solutions needed to address the challenges in developing innovative, safer, and more consistent final products. From controlled release to half-life extension, Novozymes will have a solution for you.

O’Hara Technologies Inc., Canada, Tel: +1.905.707.3286, www.oharatech.com. This year, O’Hara Technologies Inc. has been working very hard and is ready to showcase our latest innovations in tablet coating. The new Benchtop Labcoat™ (LC BT™) is designed to handle the smallest R&D batch sizes, 100– 600 gram capacity; compact, affordable, self-contained bench top design.

107 OctoPlus, The Netherlands, Tel: +31 715244044, www. octoplus.nl. OctoPlus is a drug product development S company offering proven and reliable services in combination with our drug delivery technologies for the development of controlled release formulations of injectable compounds. Such depot formulation products have demonstrated strong improvement of side-effect profiles, greatly increased patient compliance, and improved efficacy.

232B OnDrug Delivery, United Kingdom, Tel: +44 (0) 1273 78 24 24, www.ondrugdelivery.com. Established now for seven years, ONdrugDelivery is the highly regarded, leading series of sponsored themed drug delivery publications. With content from world experts at leading companies – large and small – in the global drug delivery business, ONdrugDelivery is a must for those in the industry who need to know drug delivery.

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Ortec, Inc., U.S.A., Tel: +1.864.859.1471, www.ortecinc.com. Ortec offers absorbable monomers and custom polymerization services. Glycolide, L-lactide(L&D,L), e-caprolactone, para-dioxanone, and TMC are available. Custom polymer manufacturing for drug delivery, medical device, cosmetics, and personal care is offered. Appropriate cGMP protocols and quality systems and an experienced dedicated staff help assure your market success. See website for equipment details.

Pace Analytical Life Sciences, LLC, U.S.A., www.pacelifesciences.com. Full-service, cGMPcompliant, contract analytical testing providing chemistry and microbiology services: sterility testing, bioburden, microbial limits, antimicrobial effectiveness, environmental monitoring, bacterial endotoxins, microbial identification, methods development and validation, assays, drug release profiles, dissolution, impurities, residual solvents, and elemental metals. Two FDA-established laboratories: Minnesota and Puerto Rico.

103 Patheon, U.S.A., Tel: +1.919.226.3200,

www.patheon.com. Patheon Inc. is a leading global provider of contract development and manufacturing services to the global pharmaceutical industry. Patheon’s comprehensive range of fully integrated pharmaceutical development services includes preformulation, formulation, analytical development, clinical manufacturing, scale-up, and commercialization.

518B Pharmaceutical Technology, U.S.A., Tel: +1.732.596.0276, www.pharmtech.com Pharmaceutical Technology offers news, analysis, and peer-reviewed research in formulation development (including excipients) and drug manufacturing to more than 38,000 decision-makers in the top pharmaceutical, specialty pharmaceutical, and biotechnology companies via the Pharmaceutical Technology print magazine, PharmTech.com, and three newsletters: ePT, Sourcing and Management, and the Equipment and Processing Report.

233 PharmaCircle, U.S.A.; Tel: +1.760.436.1199, Website: www.pharmacircle.com. PharmaCircle is an innovative knowledge management company providing detailed and comprehensive pharmaceutical information and analysis for research, development and regulatory professionals. Custom databases and search engines provide online interactive access to company pipelines, products, detailed drug delivery analyses, patents, clinical trials and much, much more.

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Pierre Fabre Medicament—SuperCritical Fluids Division, France, Tel: +33 (0)563812400, www.supercritical-solutions.com. Pierre Fabre Medicament Supercritical Fluids Division is a cGMP technology platform using supercritical carbon dioxide and proposing preformulation services to external partners, from development to commercial production, in the area of solubility and bioavailability improvement (Formulplex®), taste masking (Formulcoat®), modified release (Formuldisp®).

213 Polysciences, Inc., U.S.A., Tel: 1.800.523.2575, www.polysciences.com. Polysciences, Inc. provides custom manufacturing and development of biodegradable materials for drug discovery and delivery, medical devices, biotechnology, electronics, and analytical chemistry industries, as well as high-purity optical monomers, UV absorbing materials, and specialty polymer additives to the ocular lens industry.

To learn more, visit www.polysciences.com/ biomaterials.

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Purac Biomaterials, U.S.A., Tel: +1.847.634.6330, www.puracbiomaterials.com. Purac Biomaterials has more than 35 years of experience as a leading global supplier of lactide/glycolide resorbable homopolymers and copolymers. We offer a broad range of standard PURASORB® polymers and monomers as well as provide custom synthesis capabilities for specific formulation requirements.

329 & QPharma AB, Sweden, Tel: +46 40 36 18 00, 331 www.qpharma.com. QPharma is a Swedish CDMO specializing in polymeric controlled release systems, for example, intravaginal rings (IVRs) and intrauterine systems. We have been producing IVRs commercially (US, EU, and RoW) for over 18 years. The IVR is a unique delivery system: zero-order release for weeks to many months, specifically targeting women’s reproductive regions and also providing systemic delivery.

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SAIC-Frederick Inc., U.S.A., Tel: +1.301.846.5739, ncl.cancer.gov. SAIC-Frederick develops and applies a full range of biomedical technologies for the Frederick National Laboratory for Cancer Research (FNL). A key program includes an NCI-funded program for preclinical testing of nanotechnologies/ nanotherapeutics for FDA IND submission, through the FNL’s Nanotechnology Characterization Laboratory (NCL). The CRS 2012 Exhibition features full details of this enabling program.

Scintipharma, Inc., U.S.A., Tel: +1.859.276.3320, www.scintipharma.com. Scintipharma, Inc. provides services for evaluation and optimization of drug delivery systems using gamma scintigraphy. Human and animal studies are performed to evaluate dosage forms of marketed and potential therapeutic agents developed for all routes of administration. Human regional gastrointestinal drug absorption studies are performed using the InteliSite® companion capsule.

Sekisui Medical Co., Ltd., Japan, Tel: +81 3 3272 0691, www.sekisuimedical.jp/english. Sekisui Medical, based in Japan and the United States, supplies three kinds of service for worldwide pharmaceutical markets.

1) API synthesis (especially amino acids, peptides, and other low-molecular-weight small molecules), 2) ADME/Tox contract services (including in vitro ADME and transporter services through our U.S.based subsidiary XenoTech LLC) and 3) transdermal drug delivery system design and development (TDDS).

In this conference, our research and development efforts in TDDS design for peptides will be showcased.

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Sensient Pharmaceutical Coating Systems, U.S.A., Tel: 1.800.325.8110, www.sensientpharma.com.

Sensient Pharmaceutical Coating Systems is a global leader providing a comprehensive range of innovative visual enhancement solutions for the pharmaceutical and nutraceutical industries. We offer superior coating systems, custom color formulation, and imprinting inks coupled with personalized responsive service that provide our customers with brand definition, product identification, and trademark protection.

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Shin-Etsu Chemical Co. Ltd., U.S.A., Tel: +1.212.736.1580, www.biddlesawyer.com. With more than 50 years of experience in manufacturing cellulosebased pharmaceutical excipients, Shin-Etsu has developed advanced applications for their products for film coating, enteric coating, SR matrixes, rapid disintegration, and solid dispersion using methyl cellulose, hypromellose, hypromellose phthalate,

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hypromellose acetate succinate, and low-substituted hydroxypropyl cellulose. Visit www.metolose.jp or www.biddlesawyer.com.

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Simulations Plus, Inc., U.S.A., Tel: +1.661.723.7723, www.simulations-plus.com. GastroPlus simulates absorption, pharmacokinetics, and pharmacodynamics of immediate release and controlled release products administered through oral, oral cavity, ocular, and pulmonary routes. Easily build IVIVCs and conduct virtual bioequivalence trials. DDDPlus is a simulation of in vitro dissolution that enables assessing how dissolution rate changes with formulation or experimental setup.

402 Sirius Analytical, U.S.A., Tel: +1.978.338.5790, www.sirius-analytical.com. Sirius Analytical offers instrumentation and CRO services for pKa, logP/logD, solubility, and dissolution, as well as pH-dependent supersaturation and its enhancement or suppression via additives—providing data at early stages of preformulation and development, improving efficiency, and allowing informed decisions to be made earlier in the drug development process.

126 Springer, U.S.A., Tel: +1.212.460.1600, www.springer. com. Springer is the proud publisher of Drug Delivery S and Translational Research, an Official Journal of CRS as well as the book series, Advances in Delivery Science and Technology, published in partnership with CRS. Please stop by our booth to talk to our friendly publisher, Carolyn Honour about publishing with Springer.

206 & SOTAX Corporation, U.S.A., Tel: +1.508.544.4040, 208 www.sotax.com. SOTAX is a leader in dissolution and drug release testing systems, content uniformity and assay workstations, and tablet testing instruments for the pharmaceutical industry. Specialists in USP Apparatus 4 flow through dissolution for in vitro drug release testing of novel dosage forms. SPS Pharma Services offers contract method development services.

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Southwest Research Institute, U.S.A., Tel: +1.210.522.2913, www.microencapsulation.swri.org.

SwRI® provides extensive contract R&D capabilities, including the development of custom encapsulation and controlled release formulations for applications ranging from pharmaceuticals to consumer and diversified products. Capsules and particles can be prepared in sizes from nanometers to several millimeters. Biomaterials, materials development, synthesis, and modeling capabilities are also available.

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Sympatec Inc., U.S.A., Tel: +1.609.303.0066, www.sympatec.com. Sympatec is the technology leader in particle analysis. From nano-sized materials to several millimeters, we have you covered with instruments like NANOPHOX, HELOS, and QICPIC. Dry powders, suspensions, emulsions, laboratory or in-process analysis are all part of our portfolio. We have the answer to your particle size and shape questions.

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Technology Catalysts, U.S.A., Tel: +1.703.237.9600, www.technology.catalysts.com. Technology Catalysts International (TCI) is a leading consulting firm in pharmaceuticals, consumer healthcare, and drug delivery. Since 1979, TCI has offered highly customized services in technology assessment, licensing, and business intelligence. With offices in the Americas, Europe, and Asia, TCI continuously monitors technological product development activities on a global basis.

Texture Technologies Corp., U.S.A., Tel: +1.914.472.0531, www.texturetechnologies.com. TA. XTPlus and TA.HDPlus texture analyzers are used for measuring the physical properties of materials and products important to the pharmaceutical industry.

They provide extremely repeatable results for quantifying firmness, adhesiveness, disintegration, cohesiveness, swelling, and other physical properties of tablets, gels, microspheres, mucoadhesives, patches, creams, lotions, gel caps, syringability, and so on.

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Thermo Scientific, Germany, Tel: +49 (0) 721 4094 444, www.thermoscientific.com/mc_pharma. Thermo Scientific hot-melt extruders offer you the latest technology to efficiently produce solid solutions or dispersions in pharmaceutical applications. Compound, shape, and analyze your new drug online with our downstream extrusion and PAT equipment. We offer instruments and complete hot-melt extrusion solutions for your individual pharmaceutical application.

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Wyatt Technology Corporation, U.S.A., Tel: +1.805.681.9009, www.wyatt.com. DAWN MALS and DynaPro DLS instruments for determining absolute molecular weights and sizes of proteins and conjugates in solution in batch or online HPLC. Applications include proteins, polymers, nanoparticles, proteinprotein interactions, and more. The Möbius zetapotential instrument for exquisite sensitivity with delicate, small samples will also be displayed.

CRS Chapters—Reaching Around the Globe Expand your local network.

Become involved in a CRS Chapter.

Argentina Local Chapter Australian Local Chapter Canadian Local Chapter China Local Chapter Germany Local Chapter Greece Local Chapter India Local Chapter Israeli Local Chapter Italy Local Chapter Korea Local Chapter New Zealand Local Chapter Nordic Local Chapter Slovenia Local Chapter Spain-Portuguese Local Chapter Student Chapter Connecticut Student Chapter Illinois Student Chapter Johns Hopkins University Student Chapter New Jersey Student Chapter–The Hebrew University of Jerusalem Student Chapter University of California–Santa Barbara Student Chapter University of Texas Taiwan Local Chapter Thailand Local Chapter Turkey Local Chapter United Kingdom-Ireland Local Chapter

www.controlledreleasesociety.org/ community/chapters

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Sponsors of the 39th Annual Meeting & Exposition of CRS Sponsors Make It Happen Many of the meeting events are made possible only through the generosity of sponsors. Please join CRS in thanking our 2012 sponsors* who support delivery science and add value to the CRS Annual Meeting & Exposition. *Sponsors as of May 21, 2012. Please see Program Addendum for additional sponsors.

3M Drug Delivery Systems is a global leader in transdermal and inhalation drug delivery development and components. Between drug discovery and commercialization, we offer innovative and proven technology, product development services, global regulatory expertise, commercial manufacturing, and a broad range of customizable system components. Our expertise increases your opportunity for success. www.3m.com/ dds

Agilent is the new standard in dissolution! Building off the Varian and VanKel legacies for marketing-leading dissolution instrumentation, Agilent now offers apparatus, sampling systems, and analytical instruments for HPLC and UV-Vis. Plus Agilent provides a comprehensive services portfolio to ensure the method development support, regulatory guidance and laboratory expertise you require. www.agilent.com

American Pharmaceutical Review is the leading review journal for business and technology in the pharmaceutical industry throughout North America. Each issue offers unbiased editorial coverage of the latest developments in drug delivery, information technology, research & development, analytical development and control, equipment and facility manufacturing, and regulatory affairs. www.americanpharmaceuticalreview.com

Apricus Bio is a San Diego–based revenue-generating pharmaceutical company, with commercial products and a broad pipeline. Revenues and growth are driven from the sales of the company’s commercial products and through outlicensing of its NexACT® technology. For more information on NexACT multi-route drug delivery technology, please see http://www.apricusbio.com/nexact_platform.html.

Aptalis Pharmaceutical Technologies (formerly Eurand Pharmaceutical Technologies) develops and manufactures enhanced oral pharmaceutical products using its broad range of proprietary technologies, which include bioavailability enhancement of poorly soluble drugs, custom release profiles, and taste-masking formulations for a variety of dosage forms including orally disintegrating tablets. www.AptalisPharmaceuticalTechnologies.com

AstraZeneca is a global, innovation-driven, integrated biopharmaceutical company. We discover, develop, manufacture, and market prescription medicines for six important areas of healthcare, including some of the world’s most serious illnesses: cancer, cardiovascular, gastrointestinal, infection, neuroscience, and respiratory, and inflammation. We apply our scientific insight and expertise to finding breakthrough medicines. www.astrazeneca.com

AVEVA is a global leader in transdermal drug delivery located in the United States. The company has an extensive history of providing pharmaceutical partners with fully integrated, controlled-release transdermal products that fulfill unmet market needs or supply high-quality, affordable brand equivalents. By leveraging this experience, AVEVA offers a full range of research, development and manufacturing capabilities to produce transdermal pharmaceutical products that can improve the quality of life, usage and compliance rates for patients. www.avevadds.com

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Sponsors

Banner is a global drug delivery and specialty pharmaceutical company committed to researching, developing, and producing unique oral dosage forms. We offer considerable expertise in gelatin-based drug delivery systems: Versatrol™ controlled release softgels; EnteriCare™ enteric softgels; Chewels™ chewable softgels; LiquiSoft™ liquid-filled softgels; Soflet™ gelcaps; and Solvatrol™ solubility systems. www.banpharm.com

From optimizing therapeutic profiles to target drug delivery to enhancing bioavailability, we are the differentiator for your products. We have the deepest controlled release expertise, the broadest offerings, and the most innovative technologies to enhance your products and solve your challenges. Catalent.

More products. Better treatments. Reliably supplied. www.catalent.com

Coating Place has developed and manufactured modified release oral dosage products since 1976. We are the leading provider of Wurster fluid bed microencapsulation. CPI provides services from bead layering, extrusion/spheronization, and roller compaction to capsule filling and tableting. Our experience makes us the industry’s choice. www.coatingplace.com

Colorcon is a world leader in the development, supply, and technical support of formulated film coating systems, modified release technologies, and functional excipients for the pharmaceutical industry. Our best-in-class products and technologies are complemented by our value-added services, which support all phases of solid oral dose design and development. www.colorcon.com 62

Contract Pharma’s publication, Contract Pharma Direct Newsletter and website devote more coverage to contract services and outsourcing than any other source. Contract Pharma provides readers with current news, business trends, and commentary and viewpoints from industry leaders.

This editorial formula combined with value-added services make Contract Pharma the industry leader. www.contractpharma.com

Dissolution Technologies is a peer-reviewed, indexed quarterly journal reporting current information and scientific articles on dissolution testing. Books related to dissolution topics are available for sale on the searchable website, www. dissolutiontech.com. The website contains all back and current issues, and these articles are available for free as a PDF download. www.dissolutiontech.com

Drug Development & Delivery is a print and digital publication exclusively committed to advancing the applied science, technology, and related business practices of pharmaceutical and biological drug development, including: • Drug Delivery Technologies • Controlled Release • Formulation Development • Bioavailability • Medical Devices/Combination products • Contract Services • Solubility Enhancement • Life-cycle management • Regulatory issues. www.drug-dev.com DURECT Corporation is a specialty pharmaceutical company developing therapeutics based on its proprietary delivery technologies.

These technologies include the injectable depot system, ORADUR® oral sustained-release platform, TRANSDUR® transdermal technology, and DURIN™ biodegradable implant. DURECT also partners with other companies to develop and commercialize enhanced pharmaceutical products based on its technologies. www.durect.com

Sponsors EMD Millipore is the life science division of Merck KGaA. We provide excipients and other chemicals to support all stages of the drug manufacturing process from research to industrial-scale production and quality control. Our products meet the highest purity standards with extensive documentation and services to assure regulatory compliance. www.emdmillipore.com Fleet Laboratories, a family owned company since its founding in 1869, developments, manufactures, and sells OTC, personal care, and dietary supplement products in over 80 countries around the world with emphasis on gastrointestinal health and feminine hygiene and health. Fleet also has offices in Singapore and Madrid, Spain with R&D and manufacturing in Zaragoza, Spain. www.fleetlabs.com

Gattefossé is a global provider of excipients and innovative formulation technologies for enhancing drug delivery. We offer unique solutions for solubilisation, permeation enhancement, sustained release, taste masking, and more. Our products are referenced as key components of many currently marketed oral, topical, vaginal, and rectal dosage forms. www.gattefosse.com/usa

Come talk to a polymer expert at booth #306/308 about our stock and custom biodegradable polymers for drug delivery. As the oldest commercial source of biodegradable polymers in the United States, DURECT draws upon decades of experience in polymer chemistry, product development, and GMP manufacturing. www.absorbables.com

Lipoid is a manufacturer of pharmaceutical grade phospholipids from three cGMP facilities based in Germany. In addition to synthetic phospholipids used in controlled release, Lipoid produces parenteral, topical and oral grade egg, soy and rapeseed lecithin. Lipoid has over 40 Drug Master Files for excipients on file with the FDA.www.lipoid.com

LTS is one of the worldwide leading companies in creating successful products from active ingredients in innovative dosage forms, and is the market leader in the development and manufacture of transdermal therapeutic systems and oral thin films. LTS provides what drug manufacturers expect from an experienced and reliable outsourcing partner. www.lts-corp.com

Medimetrics offers customers in vivo trial services with the IntelliCap™ system for research and development studies for oral products. Applications include candidate selection/ profiling, rapid formulation prototyping, drug-drug interactions, and regional absorption. Additional applications include proof of concept studies with targeted drug delivery, enteric delivery of biologics, patient compliance monitoring, gastrointestinal tract sampling, as well as fully customized solutions for specific applications needs. www.medimetrics.com Merial is a world-leading, innovation-driven animal health company, providing a comprehensive range of products to enhance the health, well-being, and performance of a wide range of animals. Merial employs approximately 5,600 people and operates in more than 150 countries worldwide. Its 2011 sales were more than €2 billion ($2.8 billion). Merial is a Sanofi company. www.merial.com

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Sponsors

Molecular Pharmaceutics publishes high-quality research, advancing the understanding of pharmaceutics at the molecular level while providing a forum for research among the fields of physical and pharmaceutical chemistry, biochemistry, molecular and cell biology, and polymer and materials science focused on drug delivery. www. pubs.acs.org/molecularpharmaceutics

Nisso America Inc. is a wholly owned subsidiary of Nippon Soda Co., Ltd. (Tokyo, Japan), manufacturers of Nisso HPC (hydroxypropyl cellulose). Nisso HPC is available in a wide range of viscosities and particle sizes and is USP/NF, EP, and JP compliant. www.nissoexcipients.com

OctoPlus is a drug product development company offering proven and reliable services in combination with our drug delivery technologies for the development of controlled release formulations of injectable compounds. Such depot formulation products have demonstrated strong improvement of side-effect profiles, greatly increased patient compliance, and improved efficacy. www.octoplus.nl Established now for seven years, ONdrugDelivery is the highly regarded, leading series of sponsored themed drug delivery publications. With content from world experts at leading companies—large and small— in the global drug delivery business, ONdrugDelivery is a must for those in the industry who need to know drug delivery. www.ondrugdelivery.com

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Ortec offers absorbable monomers and custom polymerization services. Glycolide, L-lactide(L&D,L), e-caprolactone, paradioxanone, and TMC are available. Custom polymer manufacturing for drug delivery, medical device, cosmetics, and personal care is offered. Appropriate cGMP protocols and quality systems and an experienced dedicated staff help assure your market success. See website for equipment details. www.ortecinc.com

Pharmaceutical Technology offers news, analysis, and peerreviewed research in formulation development (including excipients) and drug manufacturing to more than 38,000 decision-makers in the top pharmaceutical, specialty pharmaceutical, and biotechnology companies via the Pharmaceutical Technology print magazine, PharmTech.com, and three newsletters: ePT, Sourcing and Management, and the Equipment and Processing Report. www.pharmtech.com

PharmaCircle is an innovative knowledge management company providing detailed and comprehensive pharmaceutical information and analysis for research, development and regulatory professionals. Custom databases and search engines provide online interactive access to company pipelines, products, detailed drug delivery analyses, patents, clinical trials and much, much more. www.pharmacircle.com

Sponsors

At Pfizer, we apply science and our global resources to improve health and well-being at every stage of life. We strive to set the standard for quality, safety, and value in the discovery, development, and manufacturing of medicines for people and animals. Our diversified global health care portfolio includes human and animal biologic and small molecule medicines and vaccines, as well as nutritional products and many of the world’s best-known consumer products. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments, and cures that challenge the most feared diseases of our time. www.pfizer.com

Pfizer Animal Health is a world leader in the discovery, development, and manufacture of vaccines and medicines for companion animals and livestock species. We work to assure a safe, sustainable food supply from healthy cattle, swine, poultry, and fish and strive to help dogs, cats, and horses live healthy longer. www.pfizerah.com

Sensient Pharmaceutical Coating Systems is a global leader providing a comprehensive range of innovative visual enhancement solutions for the pharmaceutical and nutraceutical industries. We offer superior coating systems, custom color formulation, and imprinting inks coupled with personalized responsive service that provide our customers with brand definition, product identification, and trademark protection. www.sensientpharma.com

Technology Catalysts International (TCI) is a leading consulting firm in pharmaceuticals, consumer healthcare, and drug delivery. Since 1979, TCI has offered highly customized services in technology assessment, licensing, and business intelligence. With offices in the Americas, Europe, and Asia, TCI continuously monitors technological product development activities on a global basis. www.technology-catalysts.com The Nagai Foundation Tokyo was founded in 1986 in commemoration of Prof. Tsuneji Nagai receiving the 1986 Hoest-Madsen Medal from FIP as the first for the Japanese. Then the Foundation was officially approved as government-licensed in 1994 for the purpose of promoting international exchange in pharmacy and pharmaceutical sciences. www.nagai-found.or.jp

Upsher-Smith Labs pursues drug therapies to improve lives.

Our company is driven by the ever-changing needs of patients, physicians, pharmacists, and healthcare organizations. Focused on market expansion in women’s health, dermatology, and cardiology and in developing products for neurology, our perspective is not “more products” but the “right products” to improve lives. www.upsher-smith.com

Springer is the proud publisher of Drug Delivery and Translational Research, an Official Journal of CRS as well as the book series, Advances in Delivery Science and Technology, published in partnership with CRS. Please stop by our booth to talk to our friendly publisher, Carolyn Honour about publishing with Springer. www.springer.com

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Acknowledgements CRS: By Members, for Members The incredible dedication of member volunteers is what makes CRS such a thriving society. From planning an annual meeting every year that offers top-notch science along with the best opportunities to meet with your colleagues, to developing essential products and resources like the new book series, online webcast library, constantly expanding website, and journals, CRS volunteers work tirelessly to help advance delivery science and technology. Listed here are more than 200 volunteers who devoted their time to our society this year.

CRS Board of Directors

Board of Scientific Advisors

President Martyn C. Davies University of Nottingham, United Kingdom President-Elect Kazunori Kataoka University of Tokyo, Japan

Tom Redelmeier Northern Lipids, Inc., U.S.A.

Secretary Ian G. Tucker University of Otago, New Zealand

Annual Meeting Bioactive Materials Program Committee Cochairs: Hamid Ghandehari, Dusica Maysinger.

Annual Meeting Consumer and Diversified Products Program

Committee Cochairs: Christopher W. McDaniel, Teresa Virgallito.

Annual Meeting Task Force Committee

Tamara Minko Rutgers University, U.S.A. Michael Rathbone International Medical University, Malaysia

Immediate Past President Mark A. Tracy Tracy BioConsulting, U.S.A.

Treasurer Debra Bingham Valeo Partners, U.S.A.

Members-at-Large Padma Devarajan Institute of Chemical Technology, India

Ruth Schmid SINTEF Materials and Chemistry, Norway Member-at-Large, FDA Liaison Marilyn Martinez FDA Center for Vet Medicine, U.S.A.

Books Advisory Board Chair: Michael J. Rathbone.

Members: Abdul W. Basit, Joke A. Bouwstra, Indiran Pather, Juergen Siepmann, Brigitte Skalsky, Hugh D. Smyth, Daniel Wermeling, Clive G. Wilson, David Woolfson, Jeremy C. Wright.

Books Subcommittee Chair: Michael J. Rathbone.

Members: Patrick J. Sinko, Clive G. Wilson. Ex Officio: Martyn C. Davies.

Chair: Mark A. Tracy.

Members: Debra J. Bingham, Martyn C. Davies, Kazunori Kataoka, Tamara Minko, Tom E. Redelmeier, Ruth B. Schmid.

Budget Oversight Subcommittee

Annual Meeting Veterinary Program Committee

Cochairs: Paolo Caliceti, Claudio Ortiz. Members: Misuk Bae, Jian-Xin Li, Anita Verma. Ex Officio: Padma Devarajan, Michael Rathbone.

Cochairs: Arlene McDowell, Thierry Vandamme.

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Members: Debra J. Bingham, Martha Sloboda, Tao Zheng.

Chapter Committee

Chair, Kenneth Howard Christine Allen Mansoor Amiji Aron Anderson Ben Boyd Dennis Discher Sandra Klein Andrew Lewis Tamara Minko Ozgen Ozer Yvonne Perrie Christopher Porter Pavla Simerska Hirofumi Takeuchi Iris Ziegler Ex Officio: Marilyn Martinez Ex Officio: Ian Tucker

College of Fellows Selection Committee Chair: Gary W. Cleary.

Members: Susan M. Cady, Alexander T. Florence, Lisbeth Illum, Jindrich Kopecek, Teruo Okano, Vladimir P. Torchilin.

Communication Ad Hoc Committee Chair: Ruth B. Schmid.

Members: Sarah J. Eccleston, Michael J. Valazza, Teresa Virgallito, Roderick Walker.

Consumer and Diversified Products Committee Chair: James D. Oxley. Vice Chair: Nicole PapenBotterhuis. Secretary: Allison M. Calahan. Members: Christophe J. Barbe, Yoav Blatt, Igor Bodnar, Craig R. Bunt, Kenneth H. Carson, Douglas A. Dale, Nava Dayan, Howard Epstein, Harlan S. Hall, Jamileh M. Lakkis, Christopher W. McDaniel, Jei C. McKinney,

Jean-Antoine Meiners, Kelly Miller, Claudio Ortiz, James S. Paik, Omathanu P. Perumal, Paul H. Richardson, Edith Carolina Rojas, Birgit Schleifenbaum, Rajarajeswari Sivalenka, Jon C. Soper, Srikanth Sriadibhatla, Jeffrey Tate, Robert Hans Tromp, Neal K. Vail, Ronald J. Versic, Teresa Virgallito, Tim J. Wooster, Fanwen Zeng, Zhibing Zhang.

CRS Consumer and Diversified Products Award Chair: Jamileh M. Lakkis.

Members: Christopher W. McDaniel, Claudio Ortiz.

Ex Officio: Kazunori Kataoka.

CRS Foundation Chair: Susan M. Cady.

Members: Richard H. Guy, Robert Langer, Randall J. Mrsny, Tsuneji Nagai, Kinam Park, Arthur J. Tipton.

Ex Officio: Debra J. Bingham.

CRS Founders Award Chair: Mauro Ferrari.

Members: Alexander T. Florence, Vladimir P. Torchilin.

Ex Officio: Kazunori Kataoka.

CRS JCR Award Chair: Juergen Siepmann.

Members: Theresa M. Allen, Carmen Alvarez-Lorenzo, Lisa Brannon-Peppas, Smadar Cohen, Ram I. Mahato, Ravi Kumar N. V. Majeti, Daniel W. Pack, David A. Putnam, Blanka Rihova, Garnpimol C. Ritthidej, Sevda Senel, Chun Wang, Xiao Yu Wu. Ex Officio: Kazunori Kataoka.

CRS Journal Subcommittee Chair: Diane J. Burgess.

Members: Nachiappan Chidambaram, Mansoor A. Khan, Tamara Minko.

CRS Newsletter Editorial Commitee Editor-in-Chief: Yvonne Perrie. Editors: Charles R. Frey, Steven A. Giannos, Arlene McDowell, Bozena B. Michniak-Kohn, Roderick Walker.

CRS Outstanding Oral Drug Delivery Award Chair: Jingyuan Wen. Members: Bret Berner, Maria J. Blanco-Prieto, Bruce X. Cao, Sonke Svenson, Roderick Walker. Ex Officio: Kazunori Kataoka.

CRS Outstanding Pharmaceutical Paper Award Chair: Glen S. Kwon.

Members: Tamara Minko, Juergen Siepmann, Elka Touitou. Ex Officio: Kazunori Kataoka.

CRS Outstanding Transdermal Drug Delivery Paper Award Chair: Vinod D. Labhasetwar.

Members: Kris Hansen, Kentaro Kogure. Ex Officio: Kazunori Kataoka.

CRS T. Nagai Postdoctoral Research Achievement Award Cochairs: Stefaan De Smedt, David W. Grainger, III. Members: Kazunari Akiyoshi, Won Jong Kim, Ick Chan Kwon. Ex Officio: Kazunori Kataoka.

CRS Women in Delivery Science Task Force Chair: Diane J. Burgess.

Members: Theresa M. Allen, Susan M. Cady, Jamileh M. Lakkis, Weiyue Lu, Barbara Lueckel, Ndidi C. Ngwuluka, Jun Pan, Nicole PapenBotterhuis, Julia E. RashbaStep, Louise RosenmayrTempleton, Jie Shen, MingThau Sheu, Kailas Thakker, Ae-June Wang, Elizabeth Wen. Ex Officio: Debra J. Bingham, Padma V. Devarajan, Susan Kohn, Marilyn N. Martinez, Tamara Minko, Ruth B. Schmid.

CRS Young Investigator Achievement Award Chair: Steven P. Schwendeman.

Members: Joke A. Bouwstra, Richard H. Guy, Alexander V. Kabanov, Kam W. Leong, JeanChristophe Leroux, Samir Mitragotri, Mark R. Prausnitz.

DDTR Outstanding Research Paper Selection Committee Chair: Justin S. Hanes.

Members: Sing Yian Chew, Martyn C. Davies, Padma V. Devarajan, David R. Friend, Vinod D. Labhasetwar, Natalie Medlicott, V. Prasad R. Shastri, Qiang Zhang.

Drug Delivery and Translational Research Editorial Board Editor-in-Chief: Vinod D. Labhasetwar. Associate Editors: Martyn C. Davies, Kensuke Egashira, Justin S. Hanes.

Finance Committee Chair: Debra J. Bingham.

Members: Irwin C. Jacobs, Christopher W. McDaniel, Tom E. Redelmeier, Martha Sloboda, Patrick A. Walters, Tao Zheng.

Local Chapters Argentina Chair: Joaquina Faour. Australian President: Ben J. Boyd. Canadian President: Michael Doschak. China President: Weiyue Lu. Germany President: Dagmar Fischer.

Greece President: Georgia Valsami. India President: Amarjit Singh. Israeli President: Ronit Satchi-Fainaro. Italy President: Paolo Caliceti. Korea Chair: Seung Jin Lee. New Zealand President: Arlene McDowell. Nordic Chair: Martin M. Brandl. Slovenia President: Julijana Kristl. SpainPortuguese President: Maria J. Vicent. Taiwan President: Ming-Thau Sheu. Thailand Chair: Theera Rittirod. Turkey President: Yildiz OzsoyErginer. United KingdomIreland Chair: Yvonne Perrie.

Local Chapters, Student

Membership & Development Committee Chair: Teresa Virgallito.

Cochair: Kenneth J. Miller.

Members: Perry Calias, Thomas Campbell, Prajakta Dandekar, Ratnesh Jain, Bhaumik Patel.

Ex Officio: Marilyn Martinez.

Nanomedicine Focus Group Cochairs: Hamid Ghandehari, Dusica Maysinger.

Nominating Committee Chair: Mark A. Tracy.

Members: David J. Brayden, Douglas A. Dale, Kenneth A. Howard, Kazunori Kataoka, Julia E. Rashba-Step, Ronald A. Siegel. Ex Officio: Ian Tucker.

Ocular Drug Delivery Focus Group Cochairs: Ruiwen Shi, Clive G. Wilson.

Oral Drug Delivery Focus Group Cochairs: Sarah J. Eccleston, Ali Rajabi-Siahboomi.

Connecticut President: Jill M. Steinbach. Faculty Advisor: Sangamesh G. Kumbar. Illinois President: Ryan Pearson.

Faculty Advisor: Richard A. Gemeinhart. Johns Hopkins University: Faculty Advisor: Justin S. Hanes. New Jersey President: Tannaz Ramezanli.

Faculty Advisor: Bozena B. Michniak-Kohn. The Hebrew University of Jerusalem Chair: Oren Giladi. Faculty Advisor: Abraham Rubinstein. University of California Santa Barbara President: Nishit Doshi. Faculty Advisor: Samir Mitragotri.

University of Texas President: Jean Fakhoury. Faculty Advisor: Krishnendu Roy.

Preclinical Sciences & Animal Health Division Officers

Marketing Committee

Chair: Biana Godin Vilentchouk. Members: Hamsa Jaganathan, Andrew L. Lewis, Louise Rosenmayr-Templeton, Hardik Shah. Ex Officio: Tamara Minko.

Chair: Sarah L. Reiver.

Members: Robert Bloder, Joseph A. Fix, Jei C. McKinney, Linda G. Richardson, Eyal S. Ron. Ex Officio: Tom E. Redelmeier.

Cochairs: Marilyn N. Martinez, Michael J. Rathbone.

Publications Committee Members: Diane J. Burgess, Yvonne Perrie, Michael J. Rathbone.

Satellite Meetings Task Force Chair: Claire E. MaddenSmith. Members: Kenneth J. Miller, Sarah L. Reiver, Martha Sloboda. Ex Officio: Martyn C. Davies.

Webinar Committee

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Website Editorial Committee Chair: Andrew L. Lewis.

Members: Jake E. Barralet, Biana Godin Vilentchouk, Vicki Ronaldson, Xiaoming Xu. Ex Officio: Tamara Minko.

Young Scientist Committee Cochairs: Ronnie Ortiz, Louise Rosenmayr Templeton.

Members: Raid G. Alany, David Chen, Padma V. Devarajan, Sarah J. Eccleston, Jeff James, Patrick Lim Soo, Amrita Mehta, Rafi Mohammad, Giorgia Pastorin, Michael J. Rathbone, Dody L. Reimer, Joshua Reineke, Pirthi Pal Singh, Zimei Wu, Sara Yazdi. Ex Officio: Padma Devarajan, Ruth B. Schmid.

Young Scientist MentorProtégé Subcommittee Cochairs: Padma V. Devarajan, Pirthi Pal Singh. Members: Sudip K. Das, Ozgen Ozer, Michael J. Rathbone, Teresa Virgallito.

CRS Past Presidents Mark A. Tracy Diane J. Burgess Lisbeth Illum Susan M. Cady Randall J. Mrsny Vladimir P. Torchilin Jennifer B. Dressman James Anderson Alexander T. Florence Kinam Park Richard H. Guy Gary W. Cleary Thomas H. Kissel Ronald A. Siegel Tsuneji Nagai Jindrich Kopecek Hans E. Junginger Gordon L. Amidon Vincent H.L. Lee Robert Langer Joseph R. Robinson* Jorge Heller* Lynda M. Sanders Nicholas A. Peppas Theodore J. Roseman Joseph A. Bakan* Zack Mansdorf Agis Kydonieus Danny H. Lewis Richard Baker George A. Janes* Frank W. Harris

Please Join the CRS Foundation in Honoring CRS Leaders Past, Present, and Future Monday, July 16 13:30 Plenary and Awards • Room 303 A/B Tsuneji Nagai Postdoctoral Fellowship 2011 A Year in Review

Soo Hyeon Lee

Soo Hyeon Lee will share research on the design of new delivery systems for gastrointestinal disease therapy with nucleic acid drug, conducted in the laboratory of Prof.

Jean-Christophe Leroux at ETH Zurich in Switzerland, made possible by the fellowship honoring Professor Nagai for his CRS leadership and lifetime achievements in delivery science.

Sung Wan Kim Postdoctoral Fellowship 2012 Award Presentation

*Deceased

Tram Dang

Professor Kim will award the fellowship to Tram Dang whose work at MIT led to the postdoctoral fellowship in which she will pursue research at the interface of engineering and immunology. This award honors Professor Kim for his CRS leadership and pioneering research in delivery science.

Meet the CRS Foundation’s Postdoctoral Fellows at CRS Central Monday, July 16 • 16:30 – 17:00 Tuesday, July 17 • 09:30 – 10:30

FOUNDATION

Donations are welcome.

Onsite CRS Attendee Services Desk

Online www.controlledreleasesociety.org/about/foundation The CRS Foundation thanks past and future donors.

In 2007 CRS established the CRS Foundation, a 501(c)(3) educational endowment to honor individuals who have made notable contributions to the Society and its technologies, and to support the scientific training of its future leadership.

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Does cost make you think twice about softgels?

Visit Patheon at CRS Booth #103

July 14th

Join Patheon on for Two Workshops: Formulation and Process Considerations in the Development/Scale Up of Osmotic Dosage Forms. Chaired by Don Barbieri, Patheon and Karen Coppens, Dow Wolff Cellulosics.

Think again.

Setting Release Specifications for in vitro Testing of Controlled Release Dosage Forms. Chaired

by Bob Stagner, Patheon.

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