2012 CRS Annual Meeting & Exposition Program Book by Scientific Societies

CRS 2012 Program

39th Annual Meeting & Exposition of the Controlled Release Society July 15–18, 2012 Centre des congrès de Québec Québec City, Canada

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President’s Welcome to the Annual Meeting Dear Colleagues and Friends, It is my distinct pleasure to welcome you to the 39th Annual Meeting & Exposition of the Controlled Release Society. It is difficult to believe all the hard work put in over the past year will finally culminate in these few days at the meeting, with the opportunities to discover the latest research, build new relationships, and celebrate delivery science and technology. The CRS Annual Meeting & Exposition is proud to bring together attendees and organizations from around the world. Abstract presenters alone represent 42 countries, and exhibitors will be traveling from Europe, Asia, and North America, creating a truly international gathering in this unique French-speaking province of Canada. As a scientific discipline, we rely strongly on each other’s findings, services, and technologies to advance delivery science and therefore the work each of us does. The CRS Annual Meeting & Exposition offers the perfect venue to mingle with a world’s worth of top scientists. This year’s meeting features more than 600 posters, over 100 podium speakers, an exposition hall packed with 100+ exhibitors, and much more. Three outstanding plenary speakers will offer their insights into unique topics within delivery science. The meeting will also showcase five mini-symposia, 41 invited speakers, and more than 25 scientific sessions. The popular CRS Innovation Sunday has returned, this year looking at “Game-Changing Innovation” and featuring a panel of top professionals from industry. This is in addition to Soapbox Sessions and Releasing Technology Workshops, highlighting the top companies and products in delivery science. The Roundtable and Get Up! Get Educated! Sessions have also returned, giving you a careerimproving reason to wake up early and get to the meeting.

Martyn C. Davies President Controlled Release Society

I am always in awe of the scientific sessions each year, as they reflect how quickly our science is advancing. The bioactive sessions feature all the latest trends and advances, including DNA and RNAi delivery, biomaterials, nanomedicines, and active and passive targeting. The Consumer & Diversified Products program this year is exceptionally strong, with focuses on nanoparticle technology applications, hydrogel delivery, and smart textiles. As the Veterinary Division morphs into the more inclusive Preclinical Sciences & Animal Health Division, their programming also highlights the latest in that area, including protein and vaccine delivery and therapeutics for animal patients. You can find the programming and much more on the CRS Annual Meeting Mobile App, available for download again this year and hopefully already on your mobile device! The improved mobile app has schedules, exhibition listing, a personal schedule and to-do list, and also includes CRS Connect. CRS Connect helps you make targeted connections with other meeting attendees through your mobile device and allows you to contact them and set up face-to-face meetings during the CRS Annual Meeting & Exposition. While the mobile app and CRS Connect offer the latest in technology for networking, if you prefer to do it the “old-fashioned” way, I highly recommend any of the events designed just for that. Join us at the Welcome Reception to meet with your colleagues and find new discoveries with the exhibiting companies. Make new relationships at the Young Scientist Networking Evening, Women in Science Luncheon, C&DP Division Luncheon, or Preclinical Sciences & Animal Health Get-Together. The always entertaining Kinam Park will be the highlight of the evening at the President’s Banquet on Tuesday, a great opportunity to enjoy Québec’s finest cuisine while meeting top researchers. It has been my pleasure to serve as President of the Controlled Release Society for the past year. I am very proud of all we have accomplished as a society. I look forward to seeing you here in Québec! Best Regards, Martyn C. Davies President, Controlled Release Society

Table of Contents

2012 CRS Program Team Bioactive Materials Program Chairs Hamid Ghandehari University of Utah, U.S.A. Dusica Maysinger McGill University, Canada Consumer & Diversified Products Program Chairs Christopher McDaniel Fleet Laboratories, U.S.A. Teresa Virgallito Mircrotek Labs Inc., U.S.A. Veterinary Program Chairs Arlene McDowell University of Otago, New Zealand Thierry Vandamme University of Strasbourg, France

General Meeting Information ................................................................... 3 Centre des Congrés de Québec Floor Plans .............................................. 6 Schedule-at-a-Glance Saturday – Sunday ................................................................................ 9 Monday ............................................................................................. 10 Tuesday – Wednesday ........................................................................ 11 Daily Schedule Saturday ............................................................................................. 12 Sunday ............................................................................................... 14 Sunday Releasing Technology Workshops ........................................ 17 Sunday Soapbox Sessions .................................................................. 21 Monday ............................................................................................. 23 Tuesday .............................................................................................. 30 Wednesday ......................................................................................... 39 Posters ..................................................................................................... 42 Exposition ............................................................................................... 52 Sponsors .................................................................................................. 61 Acknowledgements ................................................................................. 66

Advertisers’ Index Aptalis Pharmaceutical Technologies ...................................................... 22 www.AptalisPharmaceuticalTechnologies.com Avanti Polar Lipids ........................................................ Inside Front Cover www.avantilipids.com Grünenthal GmbH ................................................................................. 19 www.grunenthal.com OctoPlus NV............................................................................................ 13 www.octoplus.nl Michelson Prize & Grants ...................................................................... 20 www.michelson.foundanimals.org Patheon...................................................................................... Back Cover www.patheon.com Texture Technologies Corp.............................................. Inside Back Cover www.texturetechnologies.com

©Shutterstock

Controlled Release Society CRS Central ............................................................................................ 19 CRS Chapters ......................................................................................... 60 CRS Foundation ..................................................................................... 68 CRS Headquarters & Staff ..................................................................... 25 Drug Delivery and Translational Research .............................................. 38 Job Center ......................................................................................... 15, 31 Membership ............................................................................................ 33 Mobile App ............................................................................................... 5 Publications ............................................................................................. 14 40th Annual Meeting & Exposition of the ............................................. 50 Controlled Release Society

General Meeting Information The Centre des congrès de Québec is the headquarters for all workshops, sessions, the exposition, posters and the Welcome Reception. All meetings/events not being held at the Centre des congress de Québec are so noted in the Program Book. Please familiarize yourself with the location of the meetings/events you are registered to attend to reduce travel time to these off-site meetings/events.

Registration Desk

WiFi Access

The Registration Desk is located on Floor 4, Main Hall of the Centre des congrès de Québec. The desk will be open:

Co-sponsored by Texture Technologies Corp.

Saturday, July 14 Sunday, July 15 Monday, July 16 Tuesday, July 17 Wednesday, July 18

07:00 – 15:00 07:30 – 18:00 07:00 – 18:00 07:00 – 17:30 07:30 – 12:00

Access the Abstracts CRS Annual Meeting abstracts can be accessed in three ways. The CRS Annual Meeting Mobile App provides access via your mobile device or laptop; simply click on the Posters icon to begin viewing, or view podium abstracts directly from the schedule. The abstracts are available on the CRS website for all registered attendees to view and search. Both the mobile app and the website can be accessed with WiFi available at the convention center. Attendees may also view and print abstract information at the Abstract Printing Stations located near CRS Central.

Visit CRS Central Be sure to stop at CRS Central this year to see what the CRS membership has accomplished! View the new books, journals, and webcasts, and learn about committees and divisions. Take your time and sign up for the job board or become a part of the new LATTE database. Located on the 4th Floor, Loggia, outside of the Exposition.

New for 2012—CRS Connect Make targeted connections with fellow meeting attendees via CRS Connect on the CRS Annual Meeting Mobile App. Sign into the mobile app using your email address, select the CRS Connect icon, and search through the database of meeting attendees. Once you identify an individual you wish to contact, click on their name to either send them a private message or request an appointment. All of this takes place through CRS Connect while maintaining full privacy, as personal contact information is never shared. CRS has designated an area in the Exposition Hall in which CRS Connect meetings can take place.

CRS 2012 Mobile App Sponsored by Aptalis Pharmaceutical Technologies Access the meeting with the 2012 CRS Annual Meeting Mobile App. Browse the schedule, explore abstracts, create your personal schedule and to-do list, receive announcements, view exhibiting companies, and network with fellow attendees via CRS Connect. Download the CRS 2012 Mobile App by searching for “CRS Meeting” in the iTunes Store or the Android App Store/Google Play. Reach the mobile app from your Blackberry or laptop via the mobile app website mobileapp.controlledrelease.org.

CRS has contracted with the Centre des congrès de Québec to provide free WiFi service throughout the building during the annual meeting. Access will be available Saturday through Wednesday. Power up your laptop or mobile device to connect to the meeting abstracts, or utilize CRS Connect and the mobile app. Select the following to connect: Network: CRS Access code: AU21H Free WiFi access is also available without an access code at all designated Vidéotron Hot Spots within the Centre des congrès de Québec. See the floor plan on pages 6–8 for hot spot locations. Sessions are limited to 20 consecutive minutes but are renewable all day long. An Internet Café is located on level 3 and provides free access to the internet.

Exposition Hours and Location Exposition Hours and Location The Exposition is located on Floor 4, Hall 400A/B/C, and has dedicated hours when all exhibitors are present at their booths. The scheduled Exposition activities are as follows: Set-Up Saturday, July 14 08:00 – 17:00

Sunday, July 15 08:00 – 14:00

Exposition Open Sunday, July 15 17:30 – 19:30 Exposition Opening and Welcome Reception Monday, July 16 09:30 – 10:30 Networking Opportunity and Refreshment Break – Redeem your ticket for a complimentary beverage from the Café. 12:00 – 13:30 Lunch Break – Lunch and coffee available for purchase 16:30 – 17:30 New! Happy Hour and Networking Opportunity – Cash bar service Tuesday, July 17 09:30 – 10:30 Networking Opportunity and Refreshment Break – Redeem your ticket for a complimentary beverage from the Café. 12:00 – 13:30 Lunch Break – Lunch and coffee available for purchase 12:00 – 16:00 Exposition Open 15:00 – 16:00 Networking Opportunity and Refreshment Break – Redeem your ticket for a complimentary beverage from the Café. Take-Down Tuesday, July 17 16:00 – 18:00 Exhibit Take-Down

General Meeting Information continued

Poster Sessions

The posters are located in Hall 400A/B/C. All posters will be on display throughout the meeting during the designated hours. Poster authors will be present during one of three prespecified time slots. All posters must be removed at the time indicated or they will be removed and discarded. The poster viewing area will be secured overnight. Photographing posters is not permitted. 2012 Poster Schedule Sunday, July 15 08:00 – 14:00 Exhibit and Poster Set-Up 17:30 – 19:30 Poster Viewing Hours Monday, July 16 09:30 – 10:30 Poster Session #1 (authors present) 09:30 – 17:30 Poster Viewing Hours 16:30 – 17:30 New! Poster Viewing and Exposition Happy Hour Tuesday, July 17 07:00 – 16:00 Poster Viewing Hours 09:30 – 10:30 Poster Session #2 (authors present) 15:00 – 16:00 Poster Session #3 (authors present) 16:00 – 17:00 Poster Take-Down

New for 2012—Poster Snapshots Poster Snapshots are three-minute audio recordings that provide a summary preview of poster content. Attendees can listen to a recording prior to attending the poster sessions and while standing in front of a poster. Poster snapshots are submitted by poster presenters and are available through the CRS Annual Meeting Mobile App.

Speaker Preparation Room

Committee Meetings

CRS committees (and others) are invited to schedule meetings by reserving a meeting room at the Registration Desk. A limited number of meeting rooms are available for use Sunday through Wednesday. Meeting Schedule (as of May 31, 2012) Monday, July 16 Young Scientist Committee/ Mentor-Protégé Subcommittee Finance Committee Marketing Committee

09:30 – 11:00 304B 15:00 – 16:00 304B 17:30 – 18:30 304B

Tuesday, July 17 DDTR Editorial Board 07:00 – 08:00 Chapter Committee 09:30 – 11:30 JCR Editorial Board 12:00 – 14:00 Consumer & Diversified Products Division 16:00 – 17:00 Emerging Issues and Trends Advisory Committee 16:00 – 17:30 Wednesday, July 18 Books Committee Foundation Board

304B 203 Hilton Québec – Courville/ Montmorency 203 304B

07:00 – 08:00 304B 09:00 – 12:00 304B

Photography Photography is not permitted in the session rooms, exhibit hall or poster sessions. Contact CRS staff at the Registration Desk for further clarification.

Room 201A/B

Photo Release

The Speaker Preparation Room is available for PowerPoint previewing and downloading presentation materials. Speakers are to upload presentations one day prior to their presentation date, i.e., if you speak on Monday, July 16, you will upload your presentation on Sunday, July 15. Presenters are not allowed to use their own laptops.

Many photographs will be taken throughout the CRS Annual Meeting & Exposition and are used in CRS electronic and printed promotional materials during the meeting and after it has concluded. By virtue of your attendance, you agree to the Controlled Release Society’s use of your likeness in said promotional media.

The Speaker Preparation Room will be staffed and open as follows: Saturday, July 14 07:00 – 17:00 Sunday speakers upload presentations Sunday, July 15 07:00 – 17:30 Monday speakers upload presentations Monday, July 16 07:00 – 17:30 Tuesday speakers upload presentations Tuesday, July 17 07:00 – 17:30 Wednesday speakers upload presentations

Electronic Devices

Awards

Meeting and Future Event Literature

CRS will be honoring several awardees throughout the meeting. Awards will be given out at the Monday Opening Session/Award Ceremony and during the three plenary sessions. See daily highlights and the Awards & Recognition Brochure for more information.

Space for the display of promotional materials for future educational meetings is available in CRS Central. Organizers of educational meetings and events may display their materials in this reserved location. Any literature that is left in areas other than the designated location or that does not promote educational meetings will be discarded.

As a courtesy to other meeting attendees, electronic devices that ring or beep must be operated in silent/vibrate mode during all educational sessions.

Message Board For your convenience, a message board is located in CRS Central. Post a message to a colleague who is at the meeting. Job openings/resumes may also be posted.

Access the Meeting The 2012 CRS Annual Meeting & Exposition Mobile App Browse the schedule, explore abstracts, create your personal schedule and to-do list, receive announcements, view exhibiting companies, and network with fellow attendees via CRS Connect. Download the CRS 2012 Mobile App by searching for “CRS Meeting” in the iTunes Store or the Android App Store/Google Play. Reach the mobile app from your Blackberry or laptop via the mobile app website mobileapp.controlledrelease.org. Sponsored by Aptalis Pharmaceutical Technologies WiFi is available in the Centre des congrès de Québec for all CRS annual meeting attendees. Use this service free of charge on your mobile device or laptop and access all of the innovative science and networking opportunities of the CRS annual meeting via the mobile app.

Centre des congrĂ¨s de QuĂŠbec

On this level: CRS Central CRS Registration Desk Exposition Hall

Centre des congrĂ¨s de QuĂŠbec

On this level: Meetings Plenary Sessions Scientific Sessions Workshops

Centre des congrĂ¨s de QuĂŠbec

On this level: Meetings Scientific Sessions Workshops

Schedule-at-a-Glance Saturday, July 14 07:00 – 15:00 CRS Registration Open 07:00 – 17:00 Speaker Preparation Room Open 08:00 – 12:00 Educational Workshop: Formulation and Process Considerations in the Development/Scale Up of Osmotic Dosage Forms* 08:00 – 17:00 Exhibit Set-Up 08:00 – 17:00 Educational Workshop: Critical Appraisal of EPR Effect and Intratumoral Distribution of Nanomedicine* 08:00 – 17:00 Young Scientist Workshop #1: Mucosal Drug and Gene Delivery: Barriers and Opportunities 12:00 – 14:00 Leadership Forum 13:00 – 17:00 Educational Workshop: Setting Release Specifications for In Vitro Testing of Controlled Release Dosage Forms*

Floor 4, Main Hall 201A/B 206A Hall 400A/B/C 205A/B 302A/B Hilton Québec Ste. Foy/Portneuf 208A/B

Sunday, July 15 – CRS Innovation Sunday 07:00 – 17:30 07:30 – 18:00 08:00 – 12:00 08:00 – 14:00 09:00 – 10:00 09:00 – 10:00 09:00 – 10:00 10:15 – 11:15 10:15 – 11:15 10:15 – 11:15 10:30 – 12:30 11:30 – 12:30 11:30 – 12:30 11:30 – 12:30 10:00 – 12:00 11:30 – 12:30 12:30 – 14:00 12:30 – 17:30 13:00 – 15:10 13:00 – 17:30 15:30 – 17:30 17:30 – 19:30 17:30 – 19:30

Speaker Preparation Room Open CRS Registration Open Young Scientist Workshop #2: Professional and Self Development for Young Scientists and Protégés—Time Management Exhibit and Poster Set-Up Releasing Technology Workshop: Gattefossé SAS Releasing Technology Workshop: SOTAX Corporation Releasing Technology Workshop: Team Consulting Ltd. Releasing Technology Workshop: Agilent Technologies Releasing Technology Workshop: Catalent Pharma Solutions Releasing Technology Workshop: EMD Millipore Releasing Technology Workshop: OctoPlus and Mirna Therapeutics Releasing Technology Workshop: Ashland Releasing Technology Workshop: Grünenthal GmbH Releasing Technology Workshop: MedinCell SA 2013 Exhibit Selection, Group A First Timers’ Meeting Young Scientist Roundtable: Entrepreneurship: A Journey from Conception to Commercialization Educational Workshop: Preserving and Enhancing Vision via Ophthalmic Drug Delivery* Soapbox Sessions CRS Central Open Industry Roundtable: Game-Changing Innovation Co-Sponsored by Pfizer Exposition Grand Opening and Welcome Reception Poster Viewing Hours

201A/B Floor 4, Main Hall 302A/B Hall 400A/B/C 202 205C 303A 303A 202 205C 303B 205C 202 303A 203 204A/B 302A/B 205A/B 301A/B Floor 4, Loggia 301A/B Hall 400A/B/C Hall 400A/B/C

*Additional registration, payment, and ticket required. **Additional registration and ticket required.

Schedule-at-a-Glance Monday, July 16 07:00 – 08:00 07:00 – 17:30 07:00 – 18:00 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:00 09:30 – 17:00 09:30 – 17:30 10:30 – 12:00

Get Up! Get Educated! Interface of Biomaterials Elucidated Speaker Preparation Room Open CRS Registration Open CRS Opening Session Poster Session #1 (authors present) Exposition Open Young Scientist Committee/Mentor-Protégé Subcommittee Meeting CRS Central Open Poster Viewing Hours Scientific Sessions • Bioactive Materials: Biomaterials • Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization • C&DP: Fragrances and Flavors • Veterinary: Protein and Peptide Therapeutics for Animal Patients • Mini-Symposium: Active Targeting vs. Passive Targeting 11:30 – 13:30 Mentor-Protégé Meet and Greet 12:00 – 13:30 Exposition Open 13:30 – 14:45 Plenary Session: Donald A. Tomalia 14:30 – 16:30 2013 Exhibit Selection, Group B 15:00 – 16:00 Finance Committee Meeting 15:00 – 16:30 Scientific Sessions • Bioactive Materials: Nanomedicines • Bioactive Materials: Oral Controlled Release • Bioactive Materials/Veterinary: Protein and Vaccine Delivery • C&DP: Hydrogel Delivery Systems in Consumer Products • Mini-Symposium: Recombinant Polymers— Macromolecules from Microbes 16:30 – 17:30 Poster Viewing and Exposition Happy Hour 17:30 – 18:30 Marketing Committee Meeting 17:30 – 18:30 Preclinical Sciences & Animal Health Get-Together** 21:00 – 22:30 Young Scientist Networking Evening*

205A/B 201A/B Floor 4, Main Hall 303A/B Hall 400A/B/C Hall 400A/B/C 304B Floor 4, Loggia Hall 400A/B/C 303A/B 301A/B 202 205A/B 302A/B 204A/B Hall 400A/B/C 303A/B TBD 304B 303A/B 301A/B 205A/B 202 302A/B Hall 400A/B/C 304B Hilton Québec, Les Plaines Room L’Astral Restaurant, Loews Hôtel Le Concorde

*Additional registration, payment, and ticket required. **Additional registration and ticket required.

Looking for the Abstracts? Annual Meeting attendees have three convenient ways to access the abstracts. 1. Search and print abstracts for both podium presentations and posters at the Abstract Printing Station located near CRS Central. 2. Explore abstracts on your mobile device through the CRS 2012 mobile app. 3. Locate abstracts on the CRS annual meeting website by logging in with your username and password.

Schedule-at-a-Glance Tuesday, July 17 07:00 – 08:00 07:00 – 08:00 07:00 – 16:00 07:00 – 17:30 07:00 – 17:30 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:30 09:30 – 15:30 10:30 – 12:00

12:00 – 13:30 12:00 – 13:30 12:00 – 14:00 12:00 – 16:00 13:30 – 15:00

15:00 – 16:00 16:00 – 17:00 16:00 – 17:00 16:00 – 17:30 16:00 – 17:30

16:00 – 18:00 18:30 – 22:00

Get Up! Get Educated! How to Get Published in JCR— 205A/B Editor’s and Publisher’s Views DDTR Editorial Board Meeting 304B Poster Viewing Hours Hall 400A/B/C CRS Registration Open Floor 4, Main Hall Speaker Preparation Room Open 201A/B Plenary Session: Molly Shoichet 303A/B Poster Session #2 (authors present) Hall 400A/B/C Exposition Open Hall 400A/B/C Chapter Committee Meeting 203 CRS Central Open Floor 4, Loggia Scientific Sessions • Bioactive Materials: Intracellular Processes 205A/B • Bioactive Materials: DNA and RNAi Delivery 301A/B • Bioactive Materials: Drug Delivery to the Brain 303A/B • C&DP: Consumer and Industrial Applications of 202 Nanoparticle Technology • Mini-Symposium: Morphologies and Cell Responses 302A/B Women in Science Luncheon* Hilton Québec, Beauport Room C&DP Division Luncheon* Hilton Québec, Ste. Foy/Portneuf JCR Editorial Board Meeting Hilton Québec, Courville/Montmorency Exposition Open Hall 400A/B/C Scientific Sessions: • Bioactive Materials: Inorganic Nanosystems 205A/B • Bioactive Materials: Oncology and Tumor Targeting 301A/B • Bioactive Materials: Transdermal Drug Delivery 303A/B • C&DP: Nutraceuticals and Functional Foods 202 • Mini-Symposium: Smart Textiles 302A/B Poster Session #3 (authors present) Hall 400A/B/C C&DP Committee Meeting 203 Poster Take-Down Hall 400A/B/C Emerging Issues and Trends Advisory Committee Meeting 304B Roundtables and Focus Groups • Nanomedicine 302A/B • Ocular Drug Delivery 301A/B • Oral Drug Delivery 303A/B Exhibit Take-Down Hall 400A/B/C CRS President’s Banquet* Hilton Québec Ballroom

Wednesday, July 18 07:00 – 08:00 07:30 – 12:00 08:00 – 11:30 08:00 – 09:30

09:45 – 11:00 12:00 – 16:00

Books Committee Meeting CRS Registration Open CRS Central Open Scientific Sessions • Bioactive Materials: Stem Cell and Regenerative Medicines • Bioactive Materials: Theranostics and Cancer Nanotechnologies • Bioactive Materials: Translational Nanomedicine • Bioactive Materials/C&DP: Nanofibers/Nanoparticles • Mini-Symposium: New Chemistries—Click It, Fit It, Test It Plenary Session: Vladimir P. Torchilin Educational Workshop: Considerations for Future Regulatory Submissions of Transdermal Products*

304B Floor 4, Main Hall Floor 4, Loggia 303A/B 301A/B 205A/B 202 302A/B 303A/B 205A/B

*Additional registration, payment, and ticket required. **Additional registration and ticket required.

Daily Schedule Saturday, July 14

Saturday

07:00 – 15:00 CRS Registration Open 07:00 – 17:00 Speaker Preparation Room Open 08:00 – 12:00 Educational Workshop: Formulation and Process Considerations in the Development/Scale Up of Osmotic Dosage Forms* 08:00 – 17:00 Exhibit Set-Up 08:00 – 17:00 Educational Workshop: Critical Appraisal of EPR Effect and Intratumoral Distribution of Nanomedicine* 08:00 – 17:00 Young Scientist Workshop #1: Mucosal Drug and Gene Delivery: Barriers and Opportunities 12:00 – 14:00 Leadership Forum 13:00 – 17:00 Educational Workshop: Setting Release Specifications for In Vitro Testing of Controlled Release Dosage Forms*

Floor 4, Main Hall 201A/B 206A Hall 400A/B/C 205A/B 302A/B Hilton Québec Ste. Foy/Portneuf 208A/B

Saturday Program Highlights Educational Workshops*

Young Scientist Workshop #I

Critical Appraisal of EPR Effect and Intratumoral Distribution of Nanomedicine

Mucosal Drug and Gene Delivery: Barriers and Opportunities

08:00 – 17:00 • 205A/B

08:00 – 17:00 • 302A/B

Formulation and Process Considerations in the Development/Scale Up of Osmotic Dosage Forms

Speakers: Padma Devarajan, Institute of Chemical Technology, India; Camilla Foged, University of Copenhagen, Denmark; Justin Hanes, Johns Hopkins University, U.S.A.; Edith Mathiowitz, Brown University, U.S.A.; Michael Rathbone, International Medical University, Malaysia; Joshua Reineke, Wayne State University, U.S.A.; Kim Woodrow, University of Washington, U.S.A.; and Jaime Yanez, Alcon, U.S.A.

Chaired by: Khaled Gerish, University of Otago, New Zealand, and You Han Bae, University of Utah, U.S.A.

08:00 – 12:00 • 206A

Chaired by: Don Barbieri, Patheon, U.S.A., and Karen Coppens, Dow Wolff Cellulosics, U.S.A. Setting Release Specifications for In Vitro Testing of Controlled Release Dosage Forms 13:00 – 17:00 • 208A/B

Chaired by: Bob Stagner, Patheon, U.S.A.

*Additional registration, payment, and ticket required.

Chairs: Emmanuel Ho, University of Manitoba, Canada; Olivia Merkel, Wayne State University, U.S.A.; and Joshua Reineke, Wayne State University, U.S.A.

This is a workshop not to be missed by young scientists. Local drug and gene delivery offers various advantages; however, many local administration routes involve delivery to the dynamic and complex mucosa. The mucosal layer and underlying membrane are involved in the absorption and secretion of molecules and are important targets for vaccine development and treatment of diseases. In this workshop, all relevant barriers will be discussed, and successful approaches for various administration routes will be presented.

Delivery Science and Technology is a Beautiful Thing! The new technologies, the microscopic views, the unique findings— everything is conveyed better in pictures. If you have an enviable photo or full collection, CRS would love to feature it in a prominent position on the CRS homepage. A new photo is featured on the CRS homepage every few weeks, with a link to a page with a full description of the photo along with your photo credit. By sharing your images, you are explaining to delivery scientists worldwide what you are doing in your area of delivery science and technology and demonstrating just how breathtaking our science can be.

Share Your Images Stop by CRS Central or visit www.controlledreleasesociety.org/publications/imageresources/Pages/Contribute.aspx The Intellicap (schematic) courtesy of Jeff Shimizu. Corglaes courtesy of Jason King.

Daily Schedule Sunday, July 15 Speaker Preparation Room Open CRS Registration Open Young Scientist Workshop #2: Professional and Self Development for Young Scientists and Protégés—Time Management Exhibit and Poster Set-Up Releasing Technology Workshop: Gattefossé SAS Releasing Technology Workshop: SOTAX Corporation Releasing Technology Workshop: Team Consulting Ltd. Releasing Technology Workshop: Agilent Technologies Releasing Technology Workshop: Catalent Pharma Solutions Releasing Technology Workshop: EMD Millipore Releasing Technology Workshop: OctoPlus and Mirna Therapeutics Releasing Technology Workshop: Ashland Releasing Technology Workshop: Grünenthal GmbH Releasing Technology Workshop: MedinCell SA 2013 Exhibit Selection, Group A First Timers’ Meeting Young Scientist Roundtable: Entrepreneurship: A Journey from Conception to Commercialization Educational Workshop #5: Preserving and Enhancing Vision via Ophthalmic Drug Delivery* Soapbox Sessions CRS Central Open Industry Roundtable: Game-Changing Innovation Exposition Grand Opening and Welcome Reception Poster Viewing Hours

201A/B Floor 4, Main Hall 302A/B Hall 400A/B/C 202 205C 303A 303A 202 205C 303B 205C 202 303A 203 204A/B 302A/B 205A/B 301A/B Floor 4, Loggia 301A/B Hall 400A/B/C Hall 400A/B/C

*Additional registration, payment, and ticket required.

CRS—Your Delivery Science and Technology Library

CRS members % save on all purchases.

Watch for more titles in the Advances in Delivery Science and Technology series coming soon! Visit CRS Central and Booth #126 for More Information.

#8638probkfill-5/2012

Sunday

07:00 – 17:30 07:30 – 18:00 08:00 – 12:00 08:00 – 14:00 09:00 – 10:00 09:00 – 10:00 09:00 – 10:00 10:15 – 11:15 10:15 – 11:15 10:15 – 11:15 10:30 – 12:30 11:30 – 12:30 11:30 – 12:30 11:30 – 12:30 10:00 – 12:00 11:30 – 12:30 12:30 – 14:00 12:30 – 17:30 13:00 – 15:10 13:00 – 17:30 15:30 – 17:30 17:30 – 19:30 17:30 – 19:30

Sunday Program Highlights CRS Innovation Sunday

Industry Roundtable: Game-Changing Innovation

Cosponsored by Pfizer

15:30 – 17:30 • 301A/B

Releasing Technology Workshops These complimentary workshops are open to all registered attendees, offering in-depth coverage of controlled release technologies and services, hosted by the following companies: 09:00 – 10:00 09:00 – 10:00 09:00 – 10:00 10:15 – 11:15 10:15 – 11:15 10:15 – 11:15 10:30 – 12:30 11:30 – 12:30 11:30 – 12:30 11:30 – 12:30

Gattefossé SAS SOTAX Corporation Team Consulting Ltd. Agilent Technologies Catalent Pharma Solutions EMD Millipore OctoPlus and Mirna Therapeutics Ashland Grünenthal GmbH MedinCell SA

202 205C 303A 303A 202 205C 303B 205C 202 303A

See pages 17 and 18 for details.

Soapbox Sessions Cosponsored by Catalent Pharma Solutions Cochairs: Eyal S. Ron, MADASH LLC, U.S.A.; and Michael J. Valazza, Catalent Pharma Solutions 13:00 – 15:10 • 301A/B

Identify new opportunities and potential collaborations in these fast-paced presentations where technology-driven, emerging, and established businesses present their products, services, and technologies. Session breaks allow time to network with presenters at their designated tables. See page 21 for scheduled presentations of these participating companies. Agilent Technologies Andros Pharmaceuticals Co. Ltd. Critical Pharmaceuticals EMD Millipore, a division of Merck KGaA Entrega, Inc., Enlight Biosciences Enzon Pharmaceuticals, Inc. Fresenius Kabi Deutschland GmbH Giltech Glatfelter Grünenthal GmbH Harvard Medical School/Massachusetts Eye and Ear Infirmary, Ophthalmology Medimetrics Nanocopoeia, Inc. Novozymes Biopharma Phosphorex, Inc. Precision NanoSystems Starpharma Pty. Ltd. Verdex Technologies, Inc.

Moderator: Baruch Harris, Vice President, Strategy & Operations, Enlight Biosciences, U.S.A. Speakers: Julia Rashba-Step, Sr. Director, Novel Delivery Technologies, BioTx Pharmaceutical Sciences, Pfizer, U.S.A.; and Ronald L. Smith, Executive Director, Pharmaceutical Sciences, Product Value Enhancement, Merck Research Laboratories, Merck & Co., Inc., U.S.A. From Incremental to Exponential Innovation: Game Changing! If most innovation is incremental and game changers spark exponential innovation, how do you find a game changer? How do you identify one, or a dozen, game changers for your organization? Who has the skills to put the new rules into play? How do you recognize, integrate, and fully benefit from a game changer arriving from an entirely different discipline? Through panels, presentations, and audience participation, gain insight for game-changing strategies, nontraditional partners, and relationships.

Game Changer Definition: A visionary. A person or idea that transforms the accepted rules, processes, strategies, and management of business functions.

Exposition Grand Opening and Welcome Reception 17:30 – 19:30 • Hall 400 A/B/C

A day dedicated to innovation ends in the Exposition Hall with the Grand Opening of the Exposition and Welcome Reception. Join more than 100 exhibiting companies as they showcase their products, services, and still-to-be-developed innovations. Discuss your needs one-on-one with exhibitors while enjoying delicious food and beverages.

Sunday

Build your networks for success at the third annual CRS Innovation Sunday! Designed to connect you with people, research, companies, and novel technologies that address challenges in delivery, come to Sunday’s interactive program open to asking questions and finding answers.

Sunday Program Highlights Educational Workshop

First Timers’ Meeting

Preserving and Enhancing Vision via Ophthalmic Drug Delivery*

11:30 – 12:30 • 204A/B

12:30 – 17:30 • 205A/B

Chaired by: Charles Doillon, Laval University, Canada, and Todd Hoare, McMaster University, Canada

If this is your first CRS Annual Meeting & Exposition, or even if you are a seasoned veteran, learn how to get the most from the annual meeting program by attending this welcome and question-and-answer session presented by the CRS Board of Directors.

Sunday

Young Scientist Workshop #2:

Exposition Grand Opening and Welcome Reception

Professional and Self Development for Young Scientists and Protégés—Time Management

17:30 – 19:30 • Hall 400A/B/C

Cosponsored by Vision Processing 08:00 – 12:00 • 302A/B

Chaired by: Padma V. Devarajan, Institute of Chemical Technology, India; and Teresa Virgallito, Microtek Laboratories, Inc., U.S.A. Trainers: Buket Aksu, Santa Farma Ilac San AS, Turkey; and Teresa Virgallito, Microtek Labs Inc., U.S.A. Managing time effectively is extremely important for young scientists to enable them to cope with busy schedules, meeting deadlines, and so on. This workshop will cover time management skills that are needed to plan and execute projects and demonstrate how to complete project work successfully within a designated timeframe. Emphasis will be on the techniques of time management and utilization of these skills to function effectively, even under intense pressure. By applying the time-management tips and skills presented in this workshop, young scientists will learn to optimize their efforts to ensure maximum benefits. More importantly, they will understand and appreciate the value of time, with a much clearer understanding of how to use time to its greatest effect.

Young Scientist Roundtable Entrepreneurship: A Journey from Conception to Commercialization 12:30 – 14:00 • 302A/B

Chairs/Moderators: David Chen, Pfizer, U.S.A.; and Sara Yazdi, Millennium: The Takeda Oncology Company, U.S.A. Speakers: Debra Bingham, Valeo Partners, U.S.A.; Justin Hanes, Johns Hopkins University, U.S.A.; Hardik Shah, Alkermes, Ireland; and Clive Wilson, University of Strathclyde, United Kingdom This roundtable discussion brings together leaders in drug delivery to share their personal stories of the journey from conception to commercialization of an innovation and to discuss how young scientists can recognize and seize the opportunities for starting a drug delivery business venture.

*Additional registration, payment, and ticket required. 16

EMPLOYERS

Find the Right Employee in 3 Steps CRS Job Center 1. Post Your Job Description Share your job description and qualifications with skilled candidates

2. Search for Candidates Look for your new employee in our online bank of resumes

3. Contact Your Perfect Choice Once you have identified your ideal

applicant, contact them via the Job Center

Finding qualified candidates in the area of delivery science and technology has never been more targeted. Post your job today!

Special Meeting Savings Post Your Job Through August 3 and Save 20%! www.controlledreleasesociety.org/careers

09:00 – 10:00 Workshops

10:15 – 11:15 Workshops

Drug Release Testing for Combination Products Lipid Excipients: Born to Be Extruded Room 202

Presenter: Delphine Marchaud and Guest Speakers

Product life-cycle management and an overcrowded patent arena are driving interest in specialty excipients and processes. Lipid excipients have interesting functionality in oral controlled release systems and in drug solubility/bioavailability enhancement. This workshop will explain their utility in hotmelt extrusion to modulate drug dissolution, solubility, and improve processability.

Release Rate Testing of Injectable Formulations Using USP Apparatus 4—Flow-Through Dissolution Room 205C

Presenter: Samir Haddouchi, Director, SPS Pharma Services

This workshop will discuss the successful development of a dissolution method to demonstrate the release rate from an injectable formulation using USP Apparatus 4. Injectable formulations can be used for the long-term administration of fragile molecules such as proteins. A case study will be presented.

Room 303A

Presenter: Bryan Crist, Scientific Affairs Manager

As the pharmaceutical market continues to expand for low-dose combination products, analytical challenges for dependable drug release testing must keep pace. This presentation will highlight several novel products and how researchers have overcome hurdles to test medicated contact lens, drug eluting stents and balloons, catheters, vaginal rings, and implants.

Recent Advances in Oral Granules and Bi-Layer Tablet Technologies, Solubility Enhancement Solutions, and Oral Disintegrating Tablet Applications Room 202

Presenter: Michael J. Valazza, Vice President, Global Modified Release Technologies This workshop will focus on new advancements in modified controlled release technologies, including novel OSDrC® OPTIDOSE™ optimized dose delivery technology, solubility enhancement with OptiMelt™ hot-melt extrusion, and case studies of Zydis® fast-dissolve applications.

Parenteral Delivery: The Emerging Device Landscape and Potential

Drug Delivery Compounds for Parenteral Applications

Room 303A

Room 205C

Presenter: Andy Fry, Founder

Growth in biologics, reliant upon parenteral delivery, has stimulated demand for better delivery devices for a range of applications, formulations, and users. Regulators, patients, and clinicians demand devices with higher standards of safety and usability. This workshop explores these and other drivers, their interrelationships, and potential scenarios for the future.

Presenters: Mr. Robert Kriftner, Manager Drug Delivery Compounds, Global Marketing; and Dr. Adela Kalivoda, Technical Marketing Manager Delivery Systems

In its center of excellence for the development of specialty-grade lipids and activated PEGs for protein conjugation, EMD Millipore manufactures compounds in small and large quantities under cGMP in order to cover the growing demands in parenterally administered medicinal products and PEG-based hydrogels for medical devices related to surgery. 17

10:30 – 12:30 Workshop

11:30 – 12:30 Workshops

Liposomes: From Manufacturing to (Pre)Clinical Trials

Newly Launched Intermediate Hypromellose (HPMC) Grades

Industrial Application: Selection Process of Optimal Systemic Delivery Technology for Double-Stranded miRNA Mimics

Room 205C

Room 303B

Presenters: Ms. Marie-Andree Yessine, Scientist, OctoPlus; and Mr. Neil Leatherbury, Associate Director of Pharmaceutical Development, Mirna Therapeutics OctoPlus will share the challenges associated with scale up and manufacturing of liposomes, emphasizing lipid/siRNA delivery systems, followed by industrial applications of a liposome formulation. A systematic review and assessment of different systemic delivery technologies for Mirna’s proprietary miRNA mimic will be presented. Factors included, amongst others, efficiency of delivery, immune-stimulatory effects, PK and PD parameters, and overall safety and tolerability in an orthotopic mouse model of aggressive liver cancer. The current product development plan for MRX34, the company’s lead therapeutic candidate in cancer, will be highlighted, including next steps and timeline for entering into first clinical trial.

Presenter: Divya Tewari, Manager

Newly created intermediate molecular weight grades of HPMC provide solutions for controlled release applications with difficult-to-solubilize drugs that need a specific release profile. The new grades provide predictable and robust profiles even under stressed conditions where other excipients and blends fail.

Innovative Tamper Resistant Formulation (TRF) Technology—Protecting Intended Drug Action Room 202

Presenter: Prof. Dr. Johannes Bartholomaeus

Find an update on the pandemic problem of prescription drug abuse in the United States. Learn about how opioid prescription drugs are abused. How can the hurdle to these routes of abuse be raised? INTAC™—innovative tamper resistant formulation (TRF) technology—protecting intended drug action.

MedinGel: A Controlled Release Delivery Platform for Global Markets Room 303A

Presenter: Dr. Georges Gaudriault, CSO

MedinCell’s controlled release delivery platform offers wideranging durations—from several days up to one year—for many small molecules and biologics, and it requires no API modification. Current commercial partnerships aim to address delivery hurdles across arthritis, oncology, contraception, and HIV, and our low-cost manufacturing enables partners to target fast-growing emerging markets.

CRS: By Members, For Members Stop by CRS Central this year to see what the CRS membership has accomplished! With the success of new books, journals, webcasts, committees, and divisions, our CRS members truly are the “stars.” Take your time and sign up for the job board or become a part of the new LATTE database, two important member initiatives. Not a member? Or want to know how to get involved? You can do that there too! CRS Central • Floor 4, Loggia Sunday 13:00 – 17:30 09:30 – 17:00 Monday Tuesday 09:30 – 15:30 Wednesday 08:00 – 11:30

Stronger! Innovative formulation technology protecting intended drug action

The Benefits of INTAC™ Confers outstanding crush resistance Raises hurdles against prescription drug abuse

Tailor-made release properties Established at commercial manufacturing scale Featured in FDA-approved products

Dramatization!

Patient-friendly formulation; no aversive additives needed

Please see us in booth

#128

and join our workshop

For more information: info@intac.grunenthal.com Grünenthal, 52099 Aachen, Germany

DR_RZ_2150_GRUEN_0017_AZ_Intac 1

18.05.12 15:40

Soapbox Sessions Cosponsored by Catalent Pharma Solutions 13:00 – 15:10 • 301A/B

Comoderators: Eyal S. Ron, MADASH LLC, U.S.A.; and Michael J. Valazza, Catalent Pharma Solutions CRS Soapbox Sessions introduce the latest, most novel technologies, products, and services for delivery science. Identify new ideas and potential collaborations in these fast-paced presentations as well as during the one-on-one networking breaks following the presentations. 13:00 – 13:10

Introduction and Welcome Eyal S. Ron, MADASH LLC, and Michael J. Valazza, Catalent Pharma Solutions

14:05 – 14:10

13:10 – 13:15

Critical Technologies for Drug Delivery Clare Upton, Critical Pharmaceuticals

HESylation®—An Innovative Drug Delivery Technology for Proteins and Small Molecule Drugs Peter Vorstheim, Fresenius Kabi Deutschland GmbH

13:15 – 13:20

New Manufacturing of Microcapsules Lars Petersen, Glatfelter

14:15 – 14:20

Mechanical Qualification for Dissolution Apparatus: Saving Time and Money Bryan Crist, Agilent Technologies

14:10 – 14:15

13:20 – 13:25

IntelliCap—Electronic Capsule for In Vivo Studies Jeff Shimizu, Medimetrics

ElectroNanospray™ a One-Step Process for Producing Therapeutic Nanoparticles for Drug Delivery and Bioactive Medical Device Coatings Jane Nichols, Nanocopoeia, Inc.

13:25 – 13:30

A Novel Lipid-Based Carrier for the Topical Delivery of Local Anesthetics Ae-June Wang, Andros Pharmaceuticals Co. Ltd.

14:20 – 14:30

Networking Break

Session I

13:30 – 13:35

Intac™—An Innovative Formulation Technology Protecting Intended Drug Action Johannes Bartholomaeus, Grünenthal GmbH

Controlled, Sustained Release of Metal Ions from Soluble Phosphate Polymers Jason King, Giltech

13:40 – 13:50

Networking Break

13:35 – 13:40

13:55 – 14:00 14:00 – 14:05

14:30 – 14:35 14:35 – 14:40 14:40 – 14:45 14:45 – 14:50

Session II 13:50 – 13:55

Session III

New Inorganic Carrier for Solubility Enhancement Leonhard Ohrem, EMD-Millipore, a division of Merck KGaA Improving the Efficacy of Cytotoxics Through Dendrimer Technology Pauline Stanislawski, Starpharma Pty. Ltd. Contact Lens Drug Delivery Joseph Ciolino, Harvard Medical School/ Massachusetts Eye and Ear Infirmary, Ophthalmology

14:50 – 14:55

Engineering Albumin to Tailor Serum Half-Life and Improve Drug Efficacy Hans Ole Klingenberg, Novozymes Biopharma Drug Delivery—From Proof of Concept to Clinical Trials Bin Wu, Phosphorex, Inc. Microfluidic-Mediated Manufacture of “Limit-Size” Lipid Nanoparticles (lsLNP) for Drug Delivery Applications Euan Ramsay, Precision NanoSystems Bioresorbable Nanofibrous Materials with Controlled Delivery Functionalizations Larry R. Marshall, Verdex Technologies, Inc. Simple Oral Delivery of Poorly Bioavailable Molecules Baruch Harris, Entrega, Inc., Enlight Biosciences

Controlled Release of Proteins Through Releasable PEGylation Hong Zhao, Enzon Pharmaceuticals, Inc.

15:00 – 15:10

Networking Break

14:55 – 15:00

Daily Schedule Monday, July 16 Get Up! Get Educated! Interface of Biomaterials Elucidated Speaker Preparation Room Open CRS Registration Open CRS Opening Session Poster Session #1 (authors present) Exposition Open (redeem café beverage ticket) Young Scientist Committee/Mentor-Protégé Subcommittee Meeting CRS Central Open Poster Viewing Hours Scientific Sessions • Bioactive Materials: Biomaterials • Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization • C&DP: Fragrances and Flavors • Veterinary: Protein and Peptide Therapeutics for Animal Patients Cosponsored by Merial • Mini-Symposium: Active Targeting vs. Passive Targeting 11:30 – 13:30 Mentor-Protégé Meet and Greet Exposition Open (lunch available for purchase) 12:00 – 13:30 13:30 – 14:45 Plenary Session: Donald A. Tomalia 2013 Exhibit Selection, Group B 14:30 – 16:30 15:00 – 16:00 Finance Committee Meeting Scientific Sessions 15:00 – 16:30 • Bioactive Materials: Nanomedicines • Bioactive Materials: Oral Controlled Release • Bioactive Materials/Veterinary: Protein and Vaccine Delivery • C&DP: Hydrogel Delivery Systems in Consumer Products • Mini-Symposium: Recombinant Polymers— Macromolecules from Microbes 16:30 – 17:30 Poster Viewing and Exposition Happy Hour 17:30 – 18:30 Marketing Committee Meeting Preclinical Sciences & Animal Health Get-Together 17:30 – 18:30 21:00 – 22:30 Young Scientist Networking Evening*

205A/B 201A/B Floor 4, Main Hall 303A/B Hall 400A/B/C Hall 400A/B/C 304B Floor 4, Loggia Hall 400A/B/C 303A/B 301A/B

Monday

07:00 – 08:00 07:00 – 17:30 07:00 – 18:00 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 11:00 09:30 – 17:00 09:30 – 17:30 10:30 – 12:00

202 205A/B 302A/B 204A/B Hall 400A/B/C 303A/B 203 304B 303A/B 301A/B 205A/B 202 302A/B Hall 400A/B/C 304B Hilton Québec, Les Plaines Room L’Astral Restaurant, Loews Hôtel Le Concorde

*Additional registration, payment, and ticket required.

Monday Program Highlights Get Up! Get Educated!

New Format for 2012—Poster Session

Interface of Biomaterials Elucidated

Cosponsored by AstraZeneca

07:00 – 08:00 • 205A/B

Chair: Joshua Reineke, Wayne State University, U.S.A. Speaker: Vincent Rotello, University of Massachusetts Amherst, U.S.A.

Monday

Are protein adsorption, cellular adhesions, immune responses, or inflammatory reactions fogging the surface of your biomaterials? Wake up to this session illuminating the interactions of biomaterial surfaces with the complex biological milieu. This session will cover interactions and forces at the interface of materials with proteins, cellular membranes, organelles, and DNA. Learn how these interactions can determine the fate of biomaterials and of novel approaches to circumvent or advantageously utilize these interactions.

Opening Session

All scientific posters will be on display throughout the meeting. Poster authors have been designated into one of three sessions. On Monday, authors will be present at posters during the time specified below. Please use the information in the back of the program book to determine which poster authors will be present during Monday’s session. Poster information can also be found in the mobile app, CRS website, and abstract printing station. Poster Session #1: 09:30 – 10:30

Redeem your ticket for a complimentary beverage from the Café.

Mentor-Protégé Meet and Greet Chairs: Padma V. Devarajan, Institute of Chemical Technology, India; and Mike Rathbone, International Medical University, Malaysia.

08:00 – 09:30 • 303A/B

11:30 – 13:30 • 204A/B

The Opening Session will feature a welcome by President Martyn Davies, who will provide a brief update on what your association is doing to further delivery science and technology during the annual business meeting portion of the meeting. This session will also be a time to honor the 2012 CRS Distinguished Service awardee and Fellows awardees, along with the CRS T. Nagai Postdoctoral Research Achievement Award and talks from our Founders Award winner, Chezy Barenholz, and Young Investigator Award winner, Cory Berkland. Two new members of the College of Fellows will also be inducted.

Lunch will not be provided; however, attendees are invited to bring their own lunch. Lunch will be available for purchase in the exhibit hall.

This is a must-attend session for anyone enrolling in the 2011– 2012 CRS Young Scientist Mentor-Protégé Program. You will be introduced to your mentor and be given the opportunity to meet face-to-face to discuss how you are going to interact with your mentor over the next 12 months, what your career ambitions are, and what you want out of the program. Attend this meeting and gain your first CRS mentorship experience.

Plenary Speaker

Thirsty for Information? Try LATTE—Linking Academic Technologies and Techniques to Everyone—a searchable database designed to help you identify experts in specific areas of CRS-related technologies and techniques. CRS Members—You are invited to create your LATTE profile to offer your expertise to the membership and search LATTE to find the experts you are looking for.  Sign up in CRS Central or online at www.controlledreleasesociety.org/ community/Pages/LATTE.aspx

LATTE 24

Dendrimer-Based Nanomedicine—The Present and Future 13:30 – 14:45 • 303A/B

Moderator: Susan Cady, Merial Ltd., U.S.A.

Donald A. Tomalia, CEO/Founder, NanoSynthons, LLC, National Dendrimer and Nanotechnology Center, U.S.A.

Prior to the plenary, the 2012 Sung Wan Kim Postdoctoral Fellowship, will be given to Tram Dang, recent PhD graduate of Massachusetts Institute of Technology. Also, the 2011 fellowship awardee, Soo Hyeon Lee, will present research from her fellowship year at ETH Zurich.

Poster Viewing and Exposition Happy Hour 16:30 – 17:30 • Hall 400A/B/C

New for 2012! Relax after a day of sessions—meet with exhibitors, view the 600+ posters, and chat with colleagues. Beverages available for purchase.

Cosponsored by Pfizer Animal Health

17:30 – 18:30 • Hilton Québec, Les Plaines Room

Organizers: Marilyn Martinez, FDA Center for Vet Medicine, U.S.A.; Arlene McDowell, University of Otago, New Zealand; Mike Rathbone, International Medical University, Malaysia; and Thierry Vandamme, University of Strasbourg, France The new Preclinical Sciences & Animal Health Division has been established to further develop and expand the Veterinary Division. Its goal is to foster the opportunity for collaboration between CRS members interested in animal and human health. If you are interested in preclinical sciences or the science and technology of animal health products, then attend the GetTogether, mingle with like-minded people, make new contacts, and discover new opportunities for multifaceted collaborations with fellow CRS members. The Get-Together promises to be a memorable occasion. An overview of the new division will be given. The highlight of the night will be a Pub Quiz on animal health and controlled release, after which a committee will be formed to run the new division. Volunteer to be a part of this committee and take part in CRS history! There is no cost to attend the Preclinical Sciences & Animal Health Get-Together, although preregistration is required.

Young Scientist Networking Evening Organizers: David Chen, Pfizer, U.S.A.; Sarah Eccleston, Encap Drug Delivery, Scotland; Amrita Mehta, Pfizer, U.S.A.; and Joshua Reineke, Wayne State University, U.S.A. 21:00 – 22:30 • L’Astral Restaurant, Loews Hôtel Le Concorde Sponsored by Upsher-Smith Labs

Enjoy an evening of interacting with colleagues when you attend the Young Scientist networking evening and dessert reception at the only revolving rooftop restaurant in Québec City, L’Astral Restaurant at Loews Hôtel Le Concorde. Enjoy French Canadian desserts, crepes, coffee, and tea. One drink ticket is included when you register for this event. Cash bar available. Loews will be offering a dinner special for those who wish to dine at L’Astral Restaurant before the networking event. Preregistration, payment, and ticket required.

CRS Headquarters & Staff 3340 Pilot Knob Road, St. Paul, MN 55121 U.S.A. Telephone +1.651.454.7250 • Facsimile +1.651.454.0766 www.controlledreleasesociety.org

Administration Steven C. Nelson, Executive Vice President +1.651.994.3832 snelson@scisoc.org Amy Hope, Vice President of Operations +1.651.994.3827 ahope@scisoc.org Barbara Mock, Vice President of Finance +1.651.994.3829 bmock@scisoc.org Susan Kohn, Executive Director +1.651.994.3812 skohn@scisoc.org Megan Pagel, Program Manager +1.651.994.3854 mpagel@scisoc.org

Meetings Meeting Planning Leah Barna, Meeting Manager +1.651.994.3867 lbarna@scisoc.org

News Capsule Megan Pagel, Program Manager +1.651.994.3854 mpagel@scisoc.org Awards Linda Schmitt, Program Supervisor +1.651.994.3828 lschmitt@scisoc.org Chapters Megan Pagel, Chapter Coordinator +1.651.994.3854 mpagel@scisoc.org Foundation Debby Woodard, Director of Development +1.651.994.3817 dwoodard@scisoc.org Marketing Karen Deuschle, Marketing Manager +1.651.994.3804 kdeuschle@scisoc.org

Publications

Linda Schmitt, Program Supervisor +1.651.994.3828 lschmitt@scisoc.org

CRS Website and Webcasts Brian Simdars, Webmaster +1.651.994.3849 bsimdars@scisoc.org

Registration, Abstracts Sue Casey, Meeting Coordinator +1.651.994.3846 scasey@scisoc.org

Journal Liaison Greg Grahek, Publications Director +1.651.994.3841 ggrahek@scisoc.org

Exhibits, Sponsorship Debby Woodard, Director of Development +1.651.994.3817 dwoodard@scisoc.org

CRS Newsletter Carol Duling, Technical Editor +1.651.994.3869 cduling@scisoc.org

Membership and Communications

Advertising Sales Debby Woodard, Director of Development +1.651.994.3817 dwoodard@scisoc.org

Member Service Cheryl Kruchten, Member Relations Specialist +1.651.994.3801 ckruchten@scisoc.org

Monday

Preclinical Sciences & Animal Health Get-Together

Podium • Monday Morning 301A/B

303A/B

Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization

Bioactive Materials: Biomaterials

J Meiners, R Walker

10:30

Invited Speaker: Imaging Techniques for the Characterisation of Advanced Delivery Systems and Biomedical Systems M Davies University of Nottingham, UNITED KINGDOM

A Chilkoti, P Ferruti

Invited Speaker: Self-assembled polysaccharide nanogels with chaperon function for protein delivery K Akiyoshi Kyoto University, JAPAN

202

C&DP: Fragrances and Flavors

J McKinney, C Ortiz

Monday

11 Invited Speaker: Microencapsulation Using Fluid Bed System and Prilling Techniques, concepts to realities, factors associated with process development L Lee, B Patel Vision Processing Technologies LLC, U.S.A.

10:45

122 Relating the influence of temperature 7 and humidity on the surface characteristics of a spray-dried polymeric matrix consisting of poly(lactic-co-glycolic acid) and polyvinylpyrrolidone to the thermal characteristics of these polymers J Meeus, D J Scurr, X Chen, V Ciarnelli, M C Davies, C J Roberts, G Van den Mooter KU Leuven, BELGIUM 3 Confocal Raman microscopy as a 8 novel approach for development and chemically resolved characterization of a drug permeation model B Kann, S Gantzsch, U F Schaefer, C Lehr, M Windbergs Saarland University, GERMANY

Curcumin-loaded triblock poly(212 Micromanipulation and Finite Element methyl-2-oxazoline-b-tétrahydrofuraneAnalysis to Determine the Mechanical b-2-methyl-2-oxazoline) copolymer Strength of Perfume Microcapsules restores a functional ∆F508-CFTR in R Mercadé-Prieto, R Allen, Z Zhang the plasma membrane of ∆F508-CFTR University of Birmingham, UNITED cells KINGDOM P Midoux, C Gonçalves, J Gomez, B Rasolonjatovo, T Le Gal, T Montier, P Lehn, C Pichon, P Guégan, H Cheradame CNRS UPR4301, FRANCE Control of Transcription Factors by Redox Nanoparticle for Novel Antitumor Nanotherapy Y Nagasaki, Y Ozaki, T Yoshitomi University of Tsukuba, JAPAN

13 Niosome as a carrier for oral delivery of Ginkgo biloba Extract Y Jin, L Teng, W Zhang, D Liu, J Wen School of Pharmacy, University of Auckland, NEW ZEALAND

11:30

The Studies of Newly Synthesized Polymer-Coated SPION in SpragueDawley Rats S Hwang, J Ahn, H Kang, J Park, W Cho, B Sun Yonsei University, KOREA

A guanidine-substituted polyamidoamine with outstanding antiviral activity against Herpes Simplex Virus, Papilloma Virus, Cytomegalovirus and probably other DNA viruses P Ferruti, D Lembo, M Donalisio, E Ranucci, A Manfredi, R Cavalli Università di Milano, ITALY

14 Thermoplastic Shaping for Pharmaceuticals: Coupling Hot Melt Extrusion with Injection Moulding B H Liepold, M Pauli Abbott GmbH & Co KG, GERMANY

11:45

An Electrospun Triple-Layered PCLPEVA-PCL Nanofibre Matrix Controlled Release Drug Delivery System N Alhusein, P De Bank, I S Blagbrough University of Bath, UNITED KINGDOM

134 Biodegradable hydrophilic SynBiosys Pro monospheres for long-term parenteral delivery of proteins C Hiemstra, M Staal, A Lathuile, G J Veldhuis, R Steendam InnoCore Pharmaceuticals, NETHERLANDS

15 Compritol® 888 ATO Lipid Matrices for Sustained Release Processed by HotMelt Extrusion D Douroumis, M Maniruzzaman, K Vithani, S Mostafa, Y Cuppok University of Greenwich, UNITED KINGDOM

End of Session

11:00

11:15

12:00

End of Session

Podium 302A/B

205A/B

Mini Symposia: Active Targeting vs. Passive Targeting

Veterinary: Protein and Peptide Therapeutics for Animal Patients

10:30

16 Invited Speaker: Active vs Passive Targeting of Drug Delivery Systems: Opportunities and Pitfalls T M Allen University of Alberta, CANADA

10:45

17 (10:50) Invited Speaker: Design and Biorecognition of Water-Soluble Macromolecular Therapeutics J Kopecek, J Yang Universityof Utah, U.S.A.

T Vandamme, M Rathbone

20 Invited Speaker: A Spoonful of Lipid Helps the Medicine go Down.LiporaleTm- an Oral Delivery System for Mucosal Vaccination F E Aldwell Immune Solutions Ltd, NEW ZEALAND

Monday

T Lammers, R Satchi-Fainaro

11:00

11:15

18 (11:10) Invited Speaker: Ligand21 Polymeric nanoparticles for delivery of directed therapy and molecular therapeutic compounds to wild imaging based on invivo phage display animals technology A McDowell, A P Kafka, J Z Chiu, B J R Pasqualini, W Arap McLeod, T Rades University of Texas MD Anderson Cancer University of Otago, NEW ZEALAND Center, U.S.A.

11:30

19 Invited Speaker: Drug Targeting to Tumors: To Actively Target, or Not to Actively Target? G Storm, T Lammers, r schiffelers University of Utrecht, NETHERLANDS

11:45

12:00

22 Evaluating the Role of Dosage Size and Feeding on Gastric Retention in the Dog E L Mcconnell, A Lalloo, L Jin, R Elkes, H Wu Merck Sharpe & Dohme, UNITED KINGDOM

23 Quantitation of sustained release of triptorelin in beagle dog plasma by liquid chromatography-tandem mass spectrometry W Liu Yantai University, PRC PEOPLES REP OF CHINA

End of Session

Cosponsored by Merial

Podium • Monday Afternoon 205A/B

303A/B

301A/B

Bioactive Materials/Veterinary: Protein and Vaccine Delivery

Bioactive Materials: Nanomedicines

Bioactive Materials: Oral Controlled Release

S Senel, A McDowell 15:00

C Allen, M Janat-Amsbury

D Brayden, F Dorkoosh

Monday

24 Invited Speaker: Uniform PLGA Microspheres Sustain NSAID Blood Levels With Zero-Order Kinetics Q Shang, X Wang, D W Dumbauld, M Singh, M Apley, B Kukanich, C Berkland University of Kansas and Orbis Biosciences, U.S.A.

29 Invited Speaker: Nanomedicines for Hyperactive Glia D Maysinger, A R McKinney McGill University, CANADA

34 Invited Speaker: Exploiting the Biology of Microbial Toxins for Protein Delivery R Mrsny University of Bath, UNITED KINGDOM