2014 CRS Annual Meeting Program Book by Scientific Societies

CRS Annual Meeting and Exposition July 13–16, 2014 • Chicago, Illinois, U.S.A.

CRS 2014 Program

©Choose Chicago

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of Delivery Technology: Innovation to Commercialization

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President’s Welcome to the Annual Meeting translation (n): transference to a different place It isn’t easy to extract ourselves from day-to-day demands and arrive at an annual meeting miles and time zones away. But overcoming jet lag is insignificant when compared to the impact we can make when, together, we overcome the biological and technological barriers confronting us. For your efforts, passion, and professionalism, I thank you for being present at the 41st Annual Meeting & Exposition of the Controlled Release Society.

Ian Tucker

During the last year as your CRS president, I have led the drive to build an efficient, nimble society that is continually adapting to rapidly changing needs across disciplines and around the globe. I’ve talked about “controlled delivery of relevant information” that keeps our community well-informed of breakthroughs and challenges. To bring knowledge to a broader audience, I am excited to announce that a webinar series beginning in September is well underway. (Please visit CRS Central in the Exhibition Hall for more information about this initiative.) Our vibrant organization will also need to rely on the enthusiasm of young professionals to carry the torch for the next 41 years and beyond. To be the society of choice, we must continue to provide a clearly articulated sense of purpose—one we can all embrace and support through education, knowledge sharing, and partnership. Young professionals, be sure to take advantage of all the targeted programs here in Chicago, created just for you. Translation of Delivery Technology: Innovation to Commercialization is our theme this year, and it defines our critical role in transferring science and technology from research to “real world” applications. But translation also means transference to a different place. I hope you will make this year’s annual meeting a personal journey and that you emerge on the other side with new focus, renewed vigor, and the drive to contribute to the long-term success of your society. Welcome to the 41st Annual Meeting. It has been a privilege to serve as your president this past year. Ian Tucker University of Otago Dunedin, New Zealand

2014 Program Team

Table of Contents

Chair Ick Chan Kwon KIST, Korea

Deputy Chair Justin Hanes Johns Hopkins University, U.S.A.

You Han Bae University of Utah, U.S.A.

Donald Barbieri Patheon, U.S.A.

Ben Boyd Monash University, Australia

Peter Cheifetz Merial Limited, U.S.A.

General Meeting Information .................................... 4 Hilton Chicago Salons A–D Lower Level ................. 6 Schedule-at-a-Glance Saturday – Sunday ................................................. 7 Monday – Tuesday ................................................ 8 Tuesday – Wednesday ........................................... 9 Daily Schedule Saturday .............................................................. 10 Sunday ................................................................ 11 Technology Forums ........................................ 14 Soapbox Sessions ............................................ 16 Monday .............................................................. 17 Tuesday ............................................................... 24 Wednesday .......................................................... 33 Posters ...................................................................... 36 Exposition ................................................................ 45 Sponsors ................................................................... 52 Awards & Recognition ............................................. 55 Acknowledgements .................................................. 61 2014 CRS Presenting Author Index ......................... 63

Advertisers’ Index Catalent Pharma Solutions.............. Inside Front Cover www.catalent.com Patheon Pharmaceuticals Services .............. Back Cover www.patheon.com

Samir Mitragotri University of California, U.S.A.

Ruth Schmid SINTEF, Norway

Hardik Shah Alkermes Pharma Ireland Limited, Ireland

Ronald Smith Merck, U.S.A.

Geert Verreck Janssen Pharmaceutica, Belgium

Fanwen Zeng Dow Chemical Company, U.S.A.

Controlled Release Society Publications .............................................................. 19 CRS Headquarters Staff ........................................... 26 Springer .................................................................... 27 Abstracts .............................................................. 33, 56 CRS and AAPS Workshop ...................................... 44 CRS Foundation ...................................................... 60 42nd Annual Meeting & Exposition of the Controlled Release Society .......... Inside Back Cover

Access the Meeting Anytime, Anywhere 2014 CRS Annual Meeting App • • • • • •

Check the program schedule Read the abstracts Create your personal schedule and to-do lists Receive announcements Connect with fellow attendees See what companies are in the exhibit hall

Download Now. It’s Fast and Easy. Search “CRS Meeting” in your app store. Or access the app website: mobileapp.controlledrelease.org When accessing the app for the first time, you will have the option to set a password. If you choose not to set a password, no password will be needed to access your app and CRS Connect profile.

WiFi is available in the Hilton Chicago meeting spaces for all CRS annual meeting attendees, free of charge.

General Meeting Information Registration Desk

WiFi Access

The Registration Desk is located on the lower level in the Exhibit Hall Saturday through Tuesday and on lobby level at the 8th Street Registration desk on Wednesday. The desk will be open as follows:

CRS has contracted with the Hilton Chicago to provide WiFi access during the annual meeting. This access will be available to all attendees for the duration of the meeting. WiFi coverage is available throughout the meeting space at the Hilton. Power up your laptop to connect to meeting abstracts on the CRS website, or use your mobile device to utilize CRS Connect and the mobile app. Select the Hilton Chicago meeting network; after connecting with the Hilton network launch your web browser, which will redirect you to the login page.

Saturday, July 12 Sunday, July 13 Monday, July 14 Tuesday, July 15 Wednesday, July 16

07:00 – 15:00 07:30 – 18:00 07:00 – 17:30 07:00 – 17:30 07:30 – 12:00

Access the Abstracts CRS Annual Meeting abstracts can easily be accessed using the CRS Annual Meeting app, the CRS website, and the abstract printing station. The app provides access via your mobile device or laptop; simply click on the Posters icon to begin viewing poster abstracts, and view podium abstracts directly from the schedule. Sign into the CRS website to view and search the abstracts, available to all registered attendees. The abstract printing station is located in CRS Central and provides the convenience of printing abstracts of interest.

Visit CRS Central CRS tools and resources help you stay on top of the growing global and multidisciplinary field of delivery science. Check out CRS books, journals, webcasts, and other CRS offerings at CRS Central, located in Exhibit Hall Salon D.

CRS Connect As a CRS Annual Meeting attendee, CRS Connect is your foremost opportunity to network with colleagues while in Chicago. After accessing the CRS Annual Meeting app, select the CRS Connect icon and search through the database of meeting attendees. Once you identify an individual you wish to contact, click on their name to either send them a private message or request an appointment. All of this takes place through CRS Connect while maintaining full privacy, as personal contact information is never shared.

CRS Annual Meeting App View the program, read the abstracts, create your personal schedule and to-do lists, receive announcements, connect with fellow attendees using CRS Connect, and see what companies are in the Exhibit Hall—all with your CRS Annual Meeting App. Download the CRS 2014 app by searching for “CRS Meeting” in the iTunes Store or Google Play. Reach the app from your BlackBerry or laptop via the app website: mobileapp.controlledrelease.org

Electronic Devices As a courtesy to other meeting attendees, please turn off or silence all electronic devices during all workshops, sessions, and presentations.

Username: CRS2014 Password: CRS

Share Your Annual Meeting Photos on Instagram! For the first time, CRS will be using Instagram to share images taken during the annual meeting. Upload your CRS Annual Meeting photos using #CRSMeeting. Share all of your experiences while in Chicago, including the C&DP and Women in Science Luncheons, the boat tour during the Young Scientist Networking Event, Buddy Guy’s Legends during the PSAH Networking Get-Together, and more with your colleagues!

Photography Photography of scientific content is not permitted in the session rooms, exhibit hall, or poster sessions. Contact CRS staff at the Registration Desk for further clarification.

Awards CRS will be honoring several awardees throughout the meeting. Awards will be given out at the Monday Opening Session and during the three plenary sessions. See daily highlights and the Awards & Recognition section of this program book for more information.

Exposition Hours and Location The Exposition is located in the lower level Salons C & D and has dedicated hours when all exhibitors are present at their booths. The scheduled Exposition activities are as follows: Set-Up Saturday, July 12 08:00 – 17:00

Sunday, July 13 08:00 – 14:00

Exposition Open Sunday, July 13 17:30 – 19:30 Exposition Grand Opening and Welcome Reception Monday, July 14 09:30 – 10:30 Exposition Open – Meet with Exhibitors, Refreshment Break 09:30 – 17:30 Exposition Hall Open 16:30 – 17:30 Poster Viewing and Exposition Happy Hour – Meet with Exhibitors, Refreshment Break

Tuesday, July 15 09:30 – 10:30 Exposition Open – Meet with Exhibitors, Refreshment Break 09:30 – 16:00 Exposition Hall Open 15:00 – 16:00 Exposition Open – Meet with Exhibitors, Refreshment Break Take-Down Tuesday, July 15 16:00 – 18:00 Exhibit Take-Down

Poster Sessions The posters are located in Exhibit Hall Salons A & D. All posters will be on display Sunday through Tuesday during the designated hours. Poster authors will be present during one of three prespecified time slots. All posters must be removed during Poster Take-Down or they will be removed and discarded. The poster viewing area will be secured overnight. Photographing of posters is not permitted. 2014 Poster Schedule Sunday, July 13 08:00 – 14:00 Exhibit and Poster Set-Up 17:30 – 19:30 Poster Viewing Hours, Exposition Grand Opening and Welcome Reception Monday, July 14 09:30 – 10:30 Poster Session 1 – Authors Present 09:30 – 17:30 Poster Viewing Hours 16:30 – 17:30 Poster Viewing and Exposition Happy Hour Tuesday, July 15 07:00 – 16:00 Poster Viewing Hours 09:30 – 10:30 Poster Session 2 – Authors Present 15:00 – 16:00 Poster Session 3 – Authors Present 16:00 – 17:00 Poster Take-Down

Poster Snapshots Poster Snapshots are three-minute audio recordings that provide a summary preview of poster content. Attendees can listen to a recording at any time, including prior to attending the poster sessions and even while standing in front of a poster. Poster Snapshots are submitted by poster presenters and are available through the CRS Annual Meeting App.

Speaker Preparation Room PDR #2 (3rd Level) The Speaker Preparation Room is available for PowerPoint previewing and downloading presentation materials. Speakers are to upload presentations one day prior to their presentation date (e.g., if you speak on Monday, July 14, you will upload your presentation on Sunday, July 13). Presenters are not allowed to use their own laptops to give their presentations. The Speaker Preparation Room will not be open on Wednesday, July 16. The Speaker Preparation Room will be staffed and open as follows: Saturday, July 12 07:00 – 17:00 Sunday speakers upload presentations Sunday, July 13 07:00 – 17:30 Monday speakers upload presentations Monday, July 14 07:00 – 17:30 Tuesday speakers upload presentations Tuesday, July 15 07:00 – 17:30 Wednesday speakers upload presentations

Committee Meetings CRS committees (and other attendees) are invited to schedule meetings by reserving a meeting room at the Registration Desk. A limited number of meeting rooms are available for use Sunday through Wednesday. Meeting Schedule (as of June 12, 2014)

Monday, July 14 Young Scientist Committee 09:30 – 10:30 Tuesday, July 15 DDTR Editorial Board 07:00 – 08:00 International Committee 09:30 – 10:30 JCR Editorial Board 12:00 – 13:00 Satellite Meeting Committee 15:00 – 16:00 Consumer & Diversified Products Division 16:00 – 17:30 Board of Scientific Advisors 16:00 – 17:30 Wednesday, July 16 Finance Committee Volunteer Recruitment Committee 2015 CRS Annual Meeting Program Committee Preclinical Sciences & Animal Health Division

4K – 4th level 4K – 4th level 4L – 4th level 4M – 4th level 4K – 4th level 4L – 4th level 4M – 4th level

07:00 – 08:00

4K – 4th level

07:00 – 08:00

4L – 4th level

11:00 – 12:00

4M – 4th level

11:00 – 12:00

4K – 4th level

Photo Release Many photographs will be taken throughout the CRS Annual Meeting & Exposition and are used in CRS electronic and printed promotional materials during the meeting and after it has concluded. By virtue of your attendance, you agree to the Controlled Release Society’s use of your likeness in said promotional media.

Children and the CRS Annual Meeting & Exposition The CRS Annual Meeting & Exposition is a professional, scientific meeting. CRS does not permit children under the age of 18 to attend the scientific sessions, poster sessions, exposition, and social events. For safety reasons, only registered exhibitors and poster presenters are permitted in the exposition/ poster hall during set-up and take-down hours. Children 18+ must register and buy applicable individual tickets if not attending/registering as a student.

Message Board For your convenience, a message board is located next to the CRS Registration Desk. The board may be used to post job openings/resumes, messages to colleagues, or other relevant information.

Meeting and Future Event Literature Space for the display of promotional materials for future educational meetings is available near the CRS Registration Desk. Organizers of educational meetings and events may display their materials in this reserved location. Any literature that is left in areas other than the designated location or that does not promote educational meetings will be discarded.

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Schedule-at-a-Glance Saturday, July 12 07:00 – 15:00 07:00 – 17:00 08:00 – 12:00 08:00 – 17:00 08:00 – 17:00 08:00 – 17:00 08:45 – 17:00 12:00 – 14:00 13:00 – 17:00

CRS Registration Open Speaker Preparation Room Open Young Scientist Workshop: The Science of Publishing Exhibit Set-Up Premeeting Workshop: Nanotechnology – Process and Formulation, Characterization and Applications* Premeeting Workshop: Oral Delivery of Peptides and Proteins* Premeeting Workshop: Albumin: The Next Generation Protein Therapeutic* Leadership Forum (by invitation) Young Scientist Workshop: Novel Technologies in Solubility Enhancement

Exhibit Hall Salon C – lower level PDR #2 – 3rd level Marquette – 3rd level Exhibit Hall Salons C & D – lower level Continental C – lobby level Continental A – lobby level Continental B – lobby level Astoria – 3rd level Marquette – 3rd level

Sunday, July 13 07:00 – 17:30 Speaker Preparation Room Open PDR #2 – 3rd level 07:30 – 18:00 CRS Registration Open Exhibit Hall Salon C – lower level 08:00 – 12:00 Premeeting Workshop: Computational Pharmaceutics – Continental B – lobby level The Application of Computer Modeling in Drug Delivery* 08:00 – 12:00 Premeeting Workshop: Locally Acting Dermal Products – Joliet – 3rd level Global Challenges for Development and Registration* 08:00 – 12:00 Premeeting Workshop: Nanotechnology – Process and Continental C – lobby level Formulation, Characterization and Applications* 08:00 – 12:00 Premeeting Workshop: Oral Delivery of Peptides and Proteins* Continental A – lobby level 08:00 – 12:00 Young Scientist Workshop: Communication and Networking: Marquette – 3rd level How to Develop and Utilize These Skills for a Successful Career 08:00 – 14:00 Exhibit and Poster Set-Up Exhibit Hall Salons A, C & D – lower level 09:00 – 10:00 Technology Forum: Catalent Pharma Solutions Boulevard B – 2nd level 09:00 – 10:00 Technology Forum: Gattefossé Corporation Buckingham – lobby level 09:00 – 11:00 Technology Forum: Nanomi & Purac Corbion Biomaterials Boulevard C – 2nd level 09:00 – 11:15 Technology Forum: Evonik Corporation Boulevard A – 2nd level 10:15 – 11:15 Technology Forum: Lubrizol LifeScience Polymers Boulevard B – 2nd level 10:15 – 12:15 Technology Forum: Octoplus N.V., Aradigm & Regulus Buckingham – lobby level 11:30 – 12:30 First Timers’ Meeting International Ballroom South – 2nd level 11:30 – 12:30 Technology Forum: Apidel Boulevard A – 2nd level 11:30 – 12:30 Technology Forum: Patheon Pharmaceuticals Services Inc. Boulevard B – 2nd level 11:30 – 12:30 Technology Forum: Shin-Etsu Chemical Group Co. Ltd. Boulevard C – 2nd level 12:30 – 14:00 Young Scientist Roundtable: Imaging in Drug Delivery: Marquette – 3rd level Current Practice, Regulatory Challenges, and Future Trends 13:00 – 15:00 Soapbox Sessions Continental AB – lobby level 14:00 – 15:30 Mentor/Protégé Meet & Greet Marquette – 3rd level 15:30 – 17:30 Industry Roundtable: Patient Adherence and the Future Continental AB – lobby level of Innovative Drug Delivery 17:30 – 19:30 Exposition Grand Opening and Welcome Reception Exhibit Hall Salons A, C & D – lower level 17:30 – 19:30 Poster Viewing Hours Exhibit Hall Salons A & D – lower level

*Additional registration, payment, and ticket required.

Schedule-at-a-Glance Monday, July 14 07:00 – 08:00 Get Up! Get Educated! Writing a Successful Grant Application Continental C – lobby level 07:00 – 17:30 Speaker Preparation Room Open PDR #2 – 3rd level 07:00 – 17:30 CRS Registration Open Exhibit Hall Salon C – lower level 08:10 – 09:30 CRS Opening Session Grand Ballroom – 2nd level 09:30 – 10:30 Exposition Open – Meet with Exhibitors, Refreshment Break Exhibit Hall Salons C & D – lower level 09:30 – 10:30 Poster Session 1 – Authors Present Exhibit Hall Salons A & D – lower level 09:30 – 10:30 Young Scientist Committee Meeting 4K – 4th level 09:30 – 17:30 Exposition Hall Open Exhibit Hall Salons C & D – lower level 09:30 – 17:30 Poster Viewing Hours Exhibit Hall Salons A & D – lower level 10:30 – 12:00 Scientific Sessions • Advances in Process Engineering – New Methods Continental A – lobby level for the Production of Particles, Capsules, and Coatings • Innovations in Oral Drug Delivery Grand Ballroom – 2nd level • Intracellular Delivery of Nucleic Acids and Proteins Continental B – lobby level • Mini-Symposium: Interspecies Clinical Pharmacology Boulevard ABC – 2nd level Dosing Concepts • Overcoming Biological Barriers Continental C – lobby level Women in Science Luncheon* Marquette – 3rd level 12:00 – 13:30 13:30 – 14:45 Plenary Session: David W. Grainger Grand Ballroom – 2nd level Scientific Sessions 15:00 – 16:30 • Advances in RNA and DNA Delivery Grand Ballroom – 2nd level • Evaluation and Characterization of Controlled Continental A – lobby level Release Products and Production Processes • Mini-Symposium: Advancements to Develop and Delivery Continental C – lobby level Biologics • Nanoparticle-Based Delivery to the Brain Continental B – lobby level • Transdermal Delivery Boulevard ABC – 2nd level Poster Viewing and Exposition Happy Hour – Meet with Exhibit Hall Salons 16:30 – 17:30 Exhibitors, Refreshment Break A, C & D – lower level PSAH Networking Get-Together* Buddy Guy’s Legends 17:30 – 18:30 21:00 – 22:30 Young Scientist Networking Event* Mystic Blue Boat Ride – Navy Pier

Tuesday, July 15 07:00 – 08:00 07:00 – 08:00 07:00 – 16:00 07:00 – 17:30 07:00 – 17:30 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 10:30 09:30 – 16:00 10:30 – 12:00

Schedule-at-a-Glance Tuesday, July 15 (continued) 12:00 – 13:00 12:00 – 13:30 13:30 – 15:00

Journal of Controlled Release Editorial Board Meeting 4M – 4th level Consumer & Diversified Products Division Luncheon* Marquette – 3rd level Scientific Sessions: • Advances in Drug Delivery to the Lung Boulevard ABC – 2nd level • Controlled Release Applications in Food, Feed, and Beverages Continental A – lobby level • Innovations in Micro- and Nano-Based Delivery Continental B – lobby level • Mini-Symposium: Cancer Epigenetics, Epigenetic Continental C – lobby level Drugs, and Delivery • Proteins, Peptides, and Vaccines Grand Ballroom – 2nd level Exposition Open – Meet with Exhibitors, Exhibit Hall Salons C & D – lower level 15:00 – 16:00 Refreshment Break 15:00 – 16:00 Poster Session 3 – Authors Present Exhibit Hall Salons A & D – lower level Satellite Meeting Committee Meeting 4K – 4th level 15:00 – 16:00 16:00 – 17:00 Poster Take-Down Exhibit Hall Salons A & D – lower level Board of Scientific Advisors Meeting 4M – 4th level 16:00 – 17:30 College of Fellows Panel Discussion: Innovation to Continental C – lobby level 16:00 – 17:30 Commercialization 16:00 – 17:30 Consumer & Diversified Products Division Meeting 4L – 4th level Roundtables 16:00 – 17:30 • Ocular Drug Delivery Continental A – lobby level • Oral Drug Delivery Continental B – lobby level Exhibit Take-Down Exhibit Hall Salons C & D – lower 16:00 – 18:00 level CRS President’s Banquet* Boulevard ABC – 2nd level 18:30 – 22:00

Wednesday, July 16 07:00 – 08:00 07:00 – 08:00 07:30 – 12:00 08:00 – 09:30

Finance Committee Meeting Volunteer Recruitment Committee Meeting CRS Registration Open Scientific Sessions • Breakthrough Technologies • Cells as Delivery Vehicles • Controlled Release of Actives in Consumer Products • Mini-Symposium: Individualized Medicine and Theranostics • Novel Development in Formulation, Analytical Chemistry, and Processing in Animal Health and Preclinical Sciences 09:45 – 11:00 Plenary Session: David Edwards 11:00 – 12:00 2015 CRS Annual Meeting Program Committee Meeting 11:00 – 12:00 Preclinical Sciences & Animal Health Division Meeting

4K – 4th level 4L – 4th level 8th Street Registration Desk – lobby level Grand Ballroom – 2nd level Continental B – lobby level Continental A – lobby level Continental C – lobby level Boulevard ABC – 2nd level Grand Ballroom – 2nd level 4M – 4th level 4K – 4th level

*Additional registration, payment, and ticket required.

Daily Schedule Saturday, July 12

Saturday

07:00 – 15:00 07:00 – 17:00 08:00 – 12:00 08:00 – 17:00 08:00 – 17:00 08:00 – 17:00 08:45 – 17:00 12:00 – 14:00 13:00 – 17:00

Saturday Program Highlights Premeeting Workshops Oral Delivery of Peptides and Proteins* Cosponsored by Catalent Pharma Solutions 08:00 – 17:00 • Continental A – lobby level Organizers: David Brayden, University College Dublin, Ireland; and Randall Mrsny, University of Bath, United Kingdom

Controlled Release), Korea Institute of Science and Technology, Korea; Anne Marie Pordon (Publisher, Pharmacology & Pharmaceutical Sciences), Elsevier, The Netherlands; and Thomas Rades (Editor, Journal of Pharmaceutical Sciences and European Journal of Pharmaceutics and Biopharmaceutics), University of Copenhagen, Denmark;

08:00 – 17:00 • Continental C – lobby level Organizers: Teresa Virgallito, Microtek Laboratories, Inc., U.S.A.; and Nicole Papen-Botterhuis, TNO, The Netherlands

Publishing is the cornerstone of scientific research and of great importance in the career of every academic. This workshop aims to educate young scientists in the different aspects of publishing and peer review in scientific journals as well as to highlight and discuss current controversies such as open access journals, scientific integrity, impact factors, and more. The workshop will be presented by prominent editors and publishers of wellestablished pharmaceutical journals. The workshop is open to all conference attendees.

Albumin: The Next Generation Protein Therapeutic*

Novel Technologies in Solubility Enhancement

Cosponsored by Novozymes 08:45 – 17:00 • Continental B – lobby level Organizers: Kenneth Howard, Aarhus University, Denmark; and Daniel Shelly, Novozymes Biopharma US, Inc., U.S.A.

13:00 – 17:00 • Marquette – 3rd level

Nanotechnology – Process and Formulation, Characterization and Applications*

Young Scientist Workshops The Science of Publishing 08:00 – 12:00 • Marquette – 3rd level Chairs: Adam Bohr, Institute Galien Paris-Sud, France; and Jorrit Water, University of Copenhagen, Denmark Moderator: Thomas Rades, University of Copenhagen, Denmark Speakers: Ronald T. Borchardt (Editor-in-Chief, Journal of Pharmaceutical Sciences), University of Kansas, U.S.A.; Achim Göpferich (Editor-in-Chief, European Journal of Pharmaceutics and Biopharmaceutics), University of Regensburg, Germany; Ick Chan Kwon (Editor, Journal of

*Additional registration, payment, and ticket required.

Chairs: Marcus Brewster, Johnson & Johnson, Belgium; and Joke Meeus, KU Leuven, Belgium Speakers: Marcus Brewster, Johnson & Johnson, Belgium; Joe Lubach, Genentech, U.S.A.; Clive Roberts, The University of Nottingham, United Kingdom; Ben Boyd, Monash University, Australia; and Geert Verreck, Johnson & Johnson, Belgium Contemporary drug pipelines contain an increasing number of poorly water-soluble candidates. To overcome this problem, solubility-enhancing technologies often focus on impacting aspects of the Noyes–Whitney relationship by increasing dissolution rate or drug solubility. In view of this, the workshop aims to provide a context for deciding whether formulation enablement is necessary and which technique is most appropriate for which problem. Moreover, novel screening, analytical, and manufacturing approaches are within the scope of this training forum.

Daily Schedule 07:00 – 17:30 Speaker Preparation Room Open PDR #2 – 3rd level CRS Registration Open Exhibit Hall Salon C – lower level 07:30 – 18:00 Premeeting Workshop: Computational Pharmaceutics – Continental B – lobby level 08:00 – 12:00 The Application of Computer Modeling in Drug Delivery* 08:00 – 12:00 Premeeting Workshop: Locally Acting Dermal Products – Joliet – 3rd level Global Challenges for Development and Registration* Premeeting Workshop: Nanotechnology – Process and Continental C – lobby level 08:00 – 12:00 Formulation, Characterization and Applications* 08:00 – 12:00 Premeeting Workshop: Oral Delivery of Peptides and Proteins* Continental A – lobby level 08:00 – 12:00 Young Scientist Workshop: Communication and Networking: Marquette – 3rd level How to Develop and Utilize These Skills for a Successful Career 08:00 – 14:00 Exhibit and Poster Set-Up Exhibit Hall Salons A, C & D – lower level 09:00 – 10:00 Technology Forum: Catalent Pharma Solutions Boulevard B – 2nd level 09:00 – 10:00 Technology Forum: Gattefossé Corporation Buckingham – lobby level 09:00 – 11:00 Technology Forum: Nanomi & Purac Corbion Biomaterials Boulevard C – 2nd level Technology Forum: Evonik Corporation Boulevard A – 2nd level 09:00 – 11:15 Technology Forum: Lubrizol LifeScience Polymers Boulevard B – 2nd level 10:15 – 11:15 Technology Forum: Octoplus N.V., Aradigm & Regulus Buckingham – lobby level 10:15 – 12:15 First Timers’ Meeting International Ballroom South – 11:30 – 12:30 2nd level Technology Forum: Apidel Boulevard A – 2nd level 11:30 – 12:30 11:30 – 12:30 Technology Forum: Patheon Pharmaceuticals Services Inc. Boulevard B – 2nd level Technology Forum: Shin-Etsu Chemical Group Co. Ltd. Boulevard C – 2nd level 11:30 – 12:30 Young Scientist Roundtable: Imaging in Drug Delivery: Marquette – 3rd level 12:30 – 14:00 Current Practice, Regulatory Challenges, and Future Trends 13:00 – 15:00 Soapbox Sessions Continental AB – lobby level Mentor/Protégé Meet & Greet Marquette – 3rd level 14:00 – 15:30 Industry Roundtable: Patient Adherence and the Future Continental AB – lobby level 15:30 – 17:30 of Innovative Drug Delivery 17:30 – 19:30 Exposition Grand Opening and Welcome Reception Exhibit Hall Salons A, C & D – lower level 17:30 – 19:30 Poster Viewing Hours Exhibit Hall Salons A & D – lower level *Additional registration, payment, and ticket required.

Sunday

Sunday, July13

Sunday Program Highlights CRS Innovation Sunday

Soapbox Sessions

Cosponsored by Pfizer

Cosponsored by Catalent Pharma Solutions

Sunday

Delivery Science Meets Business Opportunities

13:00 – 15:00 • Continental AB – lobby level

CRS Innovation Sunday is all about the business of delivery science, taking innovative ideas and technologies into the commercial sector. All of these sessions give you important new information on companies and technologies as well as great opportunities for networking face-to-face. This is the start of the CRS Annual Meeting program—don’t miss it!

Cochairs: Joe Fix, Pharma-Fix Consulting, U.S.A.; and Michael J. Valazza, Catalent Pharma Solutions, U.S.A. Moderated by: Michael J. Valazza, Catalent Pharma Solutions

Technology Forums These workshop forums are open to all registered attendees on a complimentary basis, offering in-depth coverage of controlled release technologies and services, hosted by the following companies: 09:00 – 10:00 Catalent Pharma Solutions Gattefossé Corporation 09:00 – 11:00 Nanomi & Purac Corbion Biomaterials 09:00 – 11:15 Evonik Corporation 10:15 – 11:15 Lubrizol LifeScience Polymers

Boulevard B – 2nd level Buckingham – lobby level Boulevard C – 2nd level

Boulevard A – 2nd level Boulevard B – 2nd level

10:15 – 12:15 Octoplus N.V., Aradigm & Regulus Buckingham – lobby level 11:30 – 12:30 Apidel Patheon Pharmaceuticals Services Inc. Shin-Etsu Chemical Group Co. Ltd.

Boulevard A – 2nd level Boulevard B – 2nd level Boulevard C – 2nd level

What’s new in delivery science? Come to the program where presenters “get up on their soapbox” to give you a quick glimpse of some of the most innovative technologies and products in development today. Session breaks allow time to network with presenters at their designated tables during beverage breaks, hosted by our sponsor. Adhesives Research Apidel Avanti Polar Lipids Inc. Catalent Pharma Solutions Ceramisphere Diurnal Dow Corning Corporation Institute of Chemical & Engineering Sciences

Intec Pharma Nanocopoeia Inc. PharmaSol GmbH ProMed Pharma Southwest Research Institute SynVivo TNO University of Queensland

Industry Roundtable Cosponsored by Pfizer

15:30 – 17:30 • Continental AB – lobby level

Patient Adherence and the Future of Innovative Drug Delivery Patient non-adherence to medication takes a huge toll on healthcare budgets and on human health. Estimates indicate that in the United States alone, non-adherence to prescription regimens wastes roughly $300 billion in healthcare system costs and results in approximately 125,000 preventable deaths each year. Solving the adherence challenge is now as critical as finding the next new drug and will profoundly impact the future direction of drug delivery. This Industry Roundtable will discuss perspectives and provide insight on the latest innovative delivery technologies, devices, packaging, patient interactive feedback systems, and other future strategies to increase patient adherence and treatment outcomes. Moderator: Ronald Smith, Merck & Company, U.S.A. Panelists: Gary Cleary, Corium International, U.S.A. Tom Tice, Evonik Corp., U.S.A. Julia Rashba-Step, Pfizer, U.S.A. Ronald Smith, Merck & Company, U.S.A. Cornell Stamoran, Catalent Pharma Solutions, U.S.A.

Sunday Program Highlights Premeeting Workshops

Young Scientist Roundtable

Computational Pharmaceutics – The Application of Computer Modeling in Drug Delivery*

Imaging in Drug Delivery: Current Practice, Regulatory Challenges, and Future Trends

08:00 – 12:00 • Continental B – lobby level

Cosponsored by Aspect Imaging

Locally Acting Dermal Drug Products – Global Challenges for Development and Registration* 08:00 – 12:00 • Joliet – 3rd level

Organizers: Howard Maibach, University of California, San Francisco, U.S.A.; and Tapash Ghosh, ONDQA/CDER/ FDA, U.S.A.

12:30 – 14:00 • Marquette – 3rd level Chairs: Patrick Lim Soo, Blend Therapeutics, U.S.A.; and Jinzi Zheng, Princess Margaret Cancer Centre, Canada Speakers: Christine Allen, University of Toronto, Canada; Neesha Dhani, Princess Margaret Cancer Centre, Canada; Keyvan Farahani, Cancer Imaging Program, NCI, NIH, U.S.A.; Twan Lammers, RWTH Aachen University, Germany; and Helen Lee, Merrimack Pharmaceuticals, U.S.A.

Oral Delivery of Peptides and Proteins*

Imaging has been increasingly exploited for assessment of the in vivo performance of drug delivery systems. These include nanosystems suitable for imaging and therapy, as well as functional and molecular imaging techniques capable of assessing the effectiveness of drug targeting and delivery. However, major barriers exist for successful translation and clinical adoption of new image-guided drug delivery techniques. This roundtable brings together academic and industrial scientists, a clinician, and a funding agency representative to illustrate current advances and discuss opportunities and strategies to achieve future successes in image-guided drug delivery.

Cosponsored by Catalent Pharma Solutions

Young Scientist Mentor/Protégé Meet and Greet

Organizers: David Brayden, University College Dublin, Ireland; and Randall Mrsny, University of Bath, United Kingdom

Organized by the Young Scientist Committee

Nanotechnology – Process and Formulation, Characterization and Applications* (continued from Saturday)

08:00 – 12:00 • Continental C – lobby level

Organizers: Teresa Virgallito, Microtek Laboratories, Inc., U.S.A.; and Nicole Papen-Botterhuis, TNO, The Netherlands (continued from Saturday)

08:00 – 12:00 • Continental A – lobby level

Young Scientist Workshop Communication and Networking: How to Develop and Utilize These Skills for a Successful Career 08:00 – 12:00 • Marquette – 3rd level Chairs: Shahriar Absar, FDA, U.S.A.; and Kaushal Dave, South Dakota State University, U.S.A. Speakers: Marilyn Martinez, FDA Center for Vet Medicine, U.S.A.; Mark Prausnitz, Georgia Institute of Technology, U.S.A.; and Mark Tracy, Tracy BioConsulting LLC, U.S.A. Networking and communication have become necessary tools for a successful career. It is important to gain knowledge and be able to disseminate it among others, which requires effective communication and networking skills. This interactive workshop will discuss the tools that are necessary to sharpen one’s written and verbal communication attributes and will outline important networking strategies. Speakers will share their experience on how to reach out to a target audience and build an effective professional network. Thus, participants in this workshop will learn the most effective ways to develop and utilize networking and communication tools.

*Additional registration, payment, and ticket required.

14:00 – 15:30 • Marquette – 3rd level

This is a must-attend session for those who preregistered and were accepted into the 2014–2015 CRS Young Scientist Mentor-Protégé Program. Mentors and protégés will be introduced during this event and will be given the opportunity to discuss the protégé’s goals, exchange expectations for what is hoped to be gained from the mentoring relationship, and develop a plan of interaction for the yearlong program. Do not miss this exciting occasion to meet face-to-face with your mentor or protégé. Please note, only those who received notification of acceptance into the program may attend this event.

First Timers’ Meeting 11:30 – 12:30 • International Ballroom South – 2nd level If this is your first CRS Annual Meeting & Exposition, or even if you have attended for many years, learn how to get the most from the annual meeting program by attending this welcome and question-and-answer session presented by the CRS Board of Directors.

Grand Opening and Welcome Reception 17:30 – 19:30 • Exhibit Hall Salon A, C & D – lower level Innovation Sunday concludes in the Exposition Hall, where you’ll find more new and emerging products and services, along with the opportunity to connect with some of delivery science’s leading suppliers. Enjoy an array of foods and beverages as you meet with exhibitors, view posters, and visit with colleagues. 13

Sunday

Organizers: Defang Ouyang, Aston University, United Kingdom; and Alex Bunker, University of Helsinki, Finland

Technology Forums These forums are open to all registered attendees on a complimentary basis, offering in-depth coverage of controlled release technologies and services, hosted by the following companies:

09:00 – 10:00 Forums

Sterile by Design Boulevard B – 2nd level Presenter: Bill Hartzel, Director of Strategy Presentation Areas: Formulation, Processing, Quality & Analytical This presentation will focus on the use of advanced aseptic filling techniques utilized in blow/fill/seal technology. It will provide details on how the principles of QbD are leveraged in the equipment and process design to dramatically reduce the risk profile and particulate contamination in parenteral filling through control and automation. Company website: www.catalent.com

From Bench to Shelf: A Case Study Describing the Development, Manufacturing and Commercialization of PLG Microparticle Technology to Meet an Unmet Clinical Need Boulevard A – 2nd level Presenter: Dr. Thomas R. Tice, Sr. Director, Global Technical Marketing, Pharma Polymer & Services, Health Care Presentation Areas: Formulation, Processing Progress in delivery science and manufacturing technologies is playing a critical role in advancing the development of complex parenteral formulations. Using practical examples, this presentation will provide insight on the delivery and manufacturing of extended release formulations for peptides, proteins, and small molecules. Bioabsorbable microparticles and implant dosage forms are included. Company website: www.evonik.com/pharma

Biorelevant Models for Assessing Lipid Formulation Performance Buckingham – lobby level Chair: Delphine Marchaud, Marketing & Innovation Director, Gattefossé SAS Presenters: Prof. Anette Müllertz, University of Copenhagen, Denmark; and Dr. Yvonne Rosiaux, Manager Solid Oral Dosage Forms, Gattefossé SAS Presentation Areas: Formulation, Quality & Analytical Appropriate use of biorelevant media in (pre)formulation can translate into improved rate of success and significant savings for the drug development process. This workshop concerns biorelevant systems for assessing the performance of novel lipid-based formulations and dosage forms in both controlled release and bioavailability-enhancing systems. Company website: www.gattefosse.com

09:00 – 11:00 Forum

Life Cycle Management Strategies for Complex PLGA Injectable Particle Drug Delivery Systems Boulevard C – 2nd level Presenters: Okke Franssen, Director of Pharmaceutical Development, Nanomi; and Michiel van Alst, Director NBD & Marketing Biomaterials, Corbion Purac Biomaterials Presentation Area: Formulation Nanomi is a Dutch drug delivery company (subsidiary of Lupin) that develops pharmaceutical sustained release products based on very uniform particles. Nanomi’s complex injectables have improved injectability and offer the possibility of extending the lifetime of existing products and treating unmet medical needs/indications where current therapies fail to succeed. Corbion Purac Biomaterials develops, manufactures, and markets resorbable polymers worldwide under the PURASORB® brand name. Michiel van Alst covers the use of PURASORB polymers in controlled release formulation enabling the delivery of therapeutic API levels to patients over days, weeks, or months, with a single injection. Company websites: www.nanomi.com; www.puracbiomaterials.com

10:15 – 11:15 Forums

Advanced Functional Polymers for Targeted Oral Delivery: From Functional Coating to Bioavailability Enhancement Boulevard A – 2nd level Presenter: Dr. Min Yang, Principal Scientist, Pharma Polymers & Services, NA Region, Health Care Presentation Areas: Formulation, Processing New oral delivery technologies for BCS II/III/IV compounds are advancing patient-friendly formulations for extended, sustained, and timed release delivery. This presentation will provide insights on the current delivery science of precise targeted drug delivery systems, pulse delivery systems, and easy-to-use dispersions for enteric release and taste masking. Company website: www.evonik.com/pharma

Pathway™ Excipients – New GMP Thermoplastic Polyurethane for Implantable Drug Delivery Boulevard B – 2nd level Presenter: Pallavi Kulkarni, Ph.D., Research Chemist Presentation Area: Formulation Lubrizol LifeScience Polymers would like to introduce Pathway™ excipients, customizable GMP-grade thermoplastic polyurethane excipients that are ideal for implantable drug delivery systems. Pathway™ excipients may be formulated for zero-order release kinetics for a wide variety of hydrophilic or hydrophobic actives over short to long time periods. Company website: www.Lubrizol.com

10:15 – 12:15 Forum

Liposomes: The Process from Innovation to Market Buckingham – lobby level Presenters: Ethlinn van Gaal, Scientist, Octoplus; Dr. Priya Karmali, Senior Manager, Formulation Development, Regulus Therapeutics; and David Cipolla, Sr. Director Pharmaceutical Sciences, Aradigm Presentation Areas: Formulation, Quality & Analytical, Processing Ethlinn van Gaal will talk on the “Liposomes from Concept to Large Scale Manufacturing.” Dr. Priya Karmali will discuss “Creating New Class of Innovative Medicines Using MicroRNA Therapeutics,” and David Cipolla will address “Development of Inhaled Liposomal Ciprofloxacin to Treat Lung Infections.” Company websites: www.octoplus.nl; www.regulusrx.com; www.aradigm.com

11:30 – 12:30 Forums

Apidel Drug Delivery Company Boulevard A – 2nd level Presenters: Vincent Lenaerts, CEO; and Doris Gabriel, R&D Manager Presentation Area: Formulation Apidel is a Swiss company with two technologies: Apid-COR is a six-month release single-dose liquid formulation in prefilled syringes applicable from small molecules to proteins; Apid-SOL is a nanocarrier with unique drug transportation capabilities to the dermal and corneal tissues following topical administration. Apidel has deals with seven pharma/biotech partners. Company website: www.Apidel.com

Stepwise Approach to Preformulation and Formulation Development to Maximize Clinical Success Boulevard B – 2nd level Presenter: Paul Sabo, Sr. Scientific Leader Presentation Area: Formulation The presentation will cover suggested rapid early development strategies focusing on understanding the target product profile, importance of physicochemical properties, formulation approaches for phase 1 studies, and dealing with solubility challenges/limitations. Company website: www.patheon.com

QbD (Quality by Design) Approach to Formulations of Hydrophilic Matrix Tablets Using Sample Kit of Hypromellose (METOLOSE® SR) Boulevard C – 2nd level Presenter: Sakae Obara, Technical Director Presentation Areas: Formulation, Processing, Quality & Analytical For QbD purposes, a sample kit of hypromellose consisting of high and low extreme levels of hydroxylpropoxy content, viscosity, and particle size has been developed. The presentation will show some case studies on robustness and impact of these polymeric factors to drug release from hydrophilic matrix tablets using this sample kit. Company website: www.shinetsupharmausa.com

Soapbox Sessions Cosponsored by Catalent Pharma Solutions 13:00 – 15:00 • Continental AB – lobby level What’s new in delivery science? Come to the program where presenters “get up on their soapbox” to give you a quick glimpse of some of the most innovative technologies and products in development today. Session breaks allow time to network with presenters at their designated tables during beverage breaks, hosted by our sponsor. 13:00 – 13:10 Introduction and Welcome Moderator: Michael J. Valazza, Catalent Pharma Solutions, U.S.A.

14:00 – 14:05

Session I 13:10 – 13:15 13:15 – 13:20 13:20 – 13:25 13:25 – 13:30 13:30 – 13:35 13:35 – 13:40

13:40 – 13:50

SynVivo: A Microfluidic Platform for Screening Drug Particles B. Prabhakar Pandian, SynVivo, U.S.A. CapsMorph –Amorphous Oral Formulation Technology Based on Encapsulation in Mesoporous Materials Rainer Müller, PharmaSol GmbH, Germany Biodegradable Silica Particles for Oral and Mucosal Delivery of Vaccines Chris Barbé, Ceramisphere Pty. Ltd., Australia A Novel and Effective Drug Formulation and Delivery Platform Reginald Tan, Institute of Chemical & Engineering Sciences, Singapore The Apidel Technologies: ApidSOL Nanocarriers and ApidCOR Sustained Release Injectable Vincent Lenaerts, Apidel SA, Switzerland Overcoming the Therapeutic Challenge: Formulation Technology to Improve Acceptance and Adherence in Animal Health Dan Peizer, Catalent Pharma Solutions, U.S.A. Networking Break

Session II 13:50 – 13:55 13:55 – 14:00

The Accordion Pill™ – A New Solution for Key Unmet Needs Nadav Navon, Intec Pharma Ltd., Israel Molded Silicone Dosage Forms – Applications and Challenges Jim Arps, ProMed Pharma, U.S.A.

14:05 – 14:10 14:10 – 14:15 14:15 – 14:25

Elongate Microparticles Enhance Topical Drug Delivery in Volunteers Tarl Prow, University of Queensland, Australia Weight-Bearing Skin Adhesives for Body- Worn Devices Gozde Karabiyik, Adhesives Research, U.S.A. Efficient Topical Drug Delivery Enabled by a Novel Silicone Technology Hyder Aliyar, Dow Corning Corporation, U.S.A. Networking Break

Session III 14:25 – 14:30 14:30 – 14:35 14:35 – 14:40 14:40 – 14:45 14:45 – 14:50 14:50 – 15:00

Aurora™-Nanoparticles: Enhancing Liposomal Research Walter Shaw, Avanti Polar Lipids Inc., U.S.A. ElectroNanospray™: Particle Engineering and Rapid Nanoformulation Prototyping Jane Nichols, Nanocopoeia Inc., U.S.A. Next Generation Spray-Drying by Uniform Inkjet Printing-Drying Joris Salari, TNO, The Netherlands Chronocort® – An Innovative Modified Release Therapy for Diseases of Cortisol Deficiency Martin Whitaker, Diurnal Limited, United Kingdom Contract R&D Services at Southwest Research Institute James Oxley, Southwest Research Institute, U.S.A. Networking Break

Daily Schedule 07:00 – 08:00 Get Up! Get Educated! Writing a Successful Grant Application Continental C – lobby level Speaker Preparation Room Open PDR #2 – 3rd level 07:00 – 17:30 CRS Registration Open Exhibit Hall Salon C – lower level 07:00 – 17:30 CRS Opening Session Grand Ballroom – 2nd level 08:10 – 09:30 Exposition Open – Meet with Exhibitors, Refreshment Break Exhibit Hall Salons C & D – lower level 09:30 – 10:30 09:30 – 10:30 Poster Session 1 – Authors Present Exhibit Hall Salons A & D – lower level Young Scientist Committee Meeting 4K – 4th level 09:30 – 10:30 Exposition Hall Open Exhibit Hall Salons C & D – lower level 09:30 – 17:30 Poster Viewing Hours Exhibit Hall Salons A & D – lower level 09:30 – 17:30 10:30 – 12:00 Scientific Sessions • Advances in Process Engineering – New Methods Continental A – lobby level for the Production of Particles, Capsules, and Coatings • Innovations in Oral Drug Delivery Grand Ballroom – 2nd level • Intracellular Delivery of Nucleic Acids and Proteins Continental B – lobby level • Mini-Symposium: Interspecies Clinical Pharmacology Boulevard ABC – 2nd level Dosing Concepts • Overcoming Biological Barriers Continental C – lobby level 12:00 – 13:30 Women in Science Luncheon* Marquette – 3rd level Plenary Session: David W. Grainger Grand Ballroom – 2nd level 13:30 – 14:45 Scientific Sessions 15:00 – 16:30 • Advances in RNA and DNA Delivery Grand Ballroom – 2nd level • Evaluation and Characterization of Controlled Continental A – lobby level Release Products and Production Processes • Mini-Symposium: Advancements to Develop and Delivery Continental C – lobby level Biologics • Nanoparticle-Based Delivery to the Brain Continental B – lobby level • Transdermal Delivery Boulevard ABC – 2nd level 16:30 – 17:30 Poster Viewing and Exposition Happy Hour – Meet with Exhibit Hall Salons Exhibitors, Refreshment Break A, C & D – lower level 17:30 – 18:30 PSAH Networking Get-Together* Buddy Guy’s Legends 21:00 – 22:30 Young Scientist Networking Event* Mystic Blue Boat Ride – Navy Pier *Additional registration, payment, and ticket required.

Monday Program Highlights Get Up! Get Educated!

Opening Session

Writing a Successful Grant Application

08:10 – 09:30 • Grand Ballroom – 2nd level

07:00 – 08:00 • Continental C – lobby level

Chairs: Joke Meeus, University of Leuven, Belgium; and Yewande Oni, The University of Nottingham, United Kingdom

Speakers: Keyvan Farahani, National Institutes of Health, U.S.A.; and Clive Roberts, The University of Nottingham, United Kingdom

It is currently essential for the majority of academic and industrial scientists to apply for funding. With many funding bodies available and increasing competition, how do we begin writing an application? This session will consult an experienced academic as well as a funding body representative. They will share their experiences and invaluable tips from their perspective. This session aims to teach you how to set your application apart from others and increase your chances of securing funding.

The Opening Session will feature a welcome by President Ian Tucker, who will provide a brief update on what your association is doing to further delivery science and technology during the annual business meeting portion of the meeting. This session will also be a time to honor the 2014 CRS Distinguished Service awardee and Fellows awardees, along with talks from our Founders Award winner, Paolo Colombo; CRS T. Nagai Postdoctoral Research Achievement Award winner, Lin Zhu; and Young Investigator Award winner, Suzie Pun. Five new members of the College of Fellows will also be inducted.

continued 17

Monday

Monday, July 14

Monday Program Highlights (continued) Poster Session All scientific posters will be on display throughout the meeting. Poster authors have been designated into one of three sessions. On Monday, authors will be present at posters during the time specified below. To determine which poster authors will be present during Monday’s session, please use the poster information found in the CRS program book, meeting app, CRS website, and abstract printing station. Poster Session 1: 09:30 – 10:30

Women in Science Luncheon*

Monday

Cosponsored by Ashland Inc.

data quality with more accurate, tissue-specific information to significantly improve the technical output, predictive value, and translation between in vitro, animal, and clinical human studies. Further developments using 3D models that yield native extracellular matrix, relevant tissue architectures, and restoration of both chemical and mechanical tissue-like stimulation using bioreactors are critical for advancing in vitro experimental capabilities to obtain clinically relevant in vitro behaviors in drug screening. Prior to the plenary, the CRS Foundation’s 2014 Alexander “Sandy” Florence Postdoctoral Fellowship will be given to Christopher Nelson, Vanderbilt University, U.S.A.

12:00 – 13:30 • Marquette – 3rd level

Poster Viewing and Exposition Happy Hour

In the Middle of Difficulty Lies Opportunity

Enjoy a variety of refreshments while viewing over 500 posters on a variety of topics.

Moderator: Debra Bingham, Valeo Partners, U.S.A. Speaker: Danchen Gao, AbbVie, U.S.A. Come ready to network at this popular event and participate in a fireside chat with Danchen Gao, Director, Intellectual Property Strategy, AbbVie.

16:30 – 17:30 • Exhibit Hall Salons A & D

PSAH Networking Get-Together* Cosponsored by Merial Ltd. 17:30 – 18:30 • Buddy Guy’s Legends

Plenary Taking Shape: Transitioning 3D Assays to Improve Drug Screening and Toxicity Predictions 13:30 – 14:45 • Grand Ballroom – 2nd level Moderator: Ick Chan Kwon, KIST, Korea

David Grainger, university distinguished professor and chair of the Department of Pharmaceutics and Pharmaceutical Chemistry and a professor of bioengineering at the University of Utah, U.S.A. Many new 3D cell culture models seek to preserve in vivo-like organization within tissue-like or organoid constructs to elicit more relevant pharmacological toxicity and toxicity marker upregulation. Validation of 3D tissue culture models against 2D “gold standard cultures” for in vitro toxicological evaluation in drug testing should compare clinical toxicity biomarkers. In vitro 3D organoid models developed to date often confirm that systems with native cellular interactions better ensure biological requirements for sustaining tissue-relevant responses to drugs. These 3D cell culture models can yield better

*Additional registration, payment, and ticket required. 18

Join members of the CRS Preclinical Sciences & Animal Health (PSAH) Division and fellow meeting attendees at Chicago’s premier blues club, Buddy Guy’s Legends. The event is directly across the street from the Hilton and will begin with a brief presentation about the division and its involvement within CRS. Afterward, attendees can enjoy networking in this unique venue owned by six-time Grammy Award–winning artist Buddy Guy. You do not need to be a member of the PSAH Division to attend. Included in the ticket price are hors d’oeuvres, one drink ticket, and a wristband for admittance into the nighttime live show at the venue.

Young Scientist Networking Event* Cosponsored by Upsher-Smith Labs and Diurnal Limited 21:00 – 22:30 • Mystic Blue Boat Ride – Navy Pier Join your colleagues for an enjoyable evening of networking aboard the Mystic Blue yacht when you attend the popular Young Scientist Networking Event. Reunite with familiar faces and make new connections as you enjoy a boat cruise on Lake Michigan. The yacht will depart from and return to Navy Pier, offering spectacular panoramic views of Chicago’s world-famous skyline. Hors d’oeuvres will be served, and attendees will receive a complimentary beverage.

CRS Advances in Delivery Science and Technology Book Series

←

NEW TITLE

←

Focal Controlled Drug Delivery

Edited by A.J. Domb, School of Pharmacy-Faculty of Medicine, Jerusalem, Israel; W. Khan, School of Pharmacy-Faculty of Medicine, Jerusalem, Israel • Includes fundamental introductory chapters for focal drug delivery • Describes drug delivery to body sites/system

• Provides an authoritative account of the essential pharmaceutical, technological, physiological, and biological sciences The concept of focal drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on this subject. Thus, the aim of Focal Controlled Drug Delivery is to bring together leading experts and researchers in this field to provide an authoritative account of the essential pharmaceutical, technological, physiological, and biological sciences underpinning the topic. This book contains two sections. The first includes fundamental introductory chapters for focal drug delivery, whereas the second section includes chapters describing drug delivery to body sites/ system. The book allows clinical, pharmaceutical, and biological scientists to offer their own perspectives on the subject, making it of potential interest to a wider audience than just drug delivery scientists. 2014, XVII, hardcover, 700 pages.

Stop by Springer Booth 218 to order.

controlledreleasesociety.org

#8754-6/2014

CRS members qualify for a 25% discount on all books in the Advances in Delivery Science and Technology series from CRS, along with all Springer book titles if you purchase through Springer’s online site and use the exclusive CRS member discount token when ordering. CRS members must sign in to the CRS site to gain access to the discount token before ordering at the Springer site.

Podium • Monday Morning Monday Morning Continental A

Grand Ballroom

Advances in Process Engineering New Methods for the Production of Particles, Capsules, and Coatings

Innovations in Oral Drug Delivery

E Mathiowitz, S Lee

J Oxley, N Papen-Botterhuis

Continental B

Intracellular Delivery of Nucleic Acids and Proteins S Pun, Y Katayama

Production of Nano/Micro Drug Particles by Supercritical Fluid Technology S Sathigari Patheon Pharmaceuticals, U.S.A.

Invited Speaker: Oral delivery of heparin conjugate Y Byun Seoul National University, Korea

11 Invited Speaker: Intracellular Delivery of BIologic Drugs P Stayton University of Washington, U.S.A.

11:00

The NanoAssemblr Platform: Scalable, Microfluidics-based Manufacture of siRNA Lipid Nanoparticles C L Walsh, K Ou, A Ansari, T J Leaver, A W Wild, R J Taylor, E Ramsay, P R Cullis Precision NanoSystems Inc., U.S.A.

Synergistic Effect of M Cell Targeting Peptide and Mucoadhesive Vehicle on Induction of Immune Responses in Oral Vaccine Delivery C Cho Seoul National University, South Korea

13 Nucleodendrimers for endosomal escape S Muro University of Maryland, U.S.A.

11:15

Accepting the challenge of scale-up - A 8 new approach for the treatment of colon cancer based on nanoparticles overcomes the limitations of batch size S Beyer Goethe University, Germany

Can ion pairing mediate drug uptake via active carriers? A ElShaer, A S Rahman, P Hanson, A R Mohammed Kingston University, United Kingdom

11:30

Dissolution of Poorly Soluble Drug Nanoparticles from Edible Polymer Stripfilms J Zhang, Z Ma, E Bilgili, R N Davé Chemical Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, U.S.A.

High-throughput, slit-surface, coresheath electrospinning: Improving the formulation and dissolution of poorly soluble drugs Q Pham, E Fan, L Ruiz, J Podyma, R Mulligan, T Freyman Arsenal Medical, U.S.A.

12 The Multifaceted Role of Glycosaminoglycans in the Cellular Uptake of Cell-Penetrating Peptides R Wallbrecher, S Schmidt, W P Verdurmen, P H Bovee-Geurts, F Bröcker, A Reinhardt, T H van Kuppevelt, J Eilander, S Fanghänel, J Bürck, P Wadhwani, P H Seeberger, A S Ulrich, R Brock Radboud University Medical Centre, Netherlands 14 Wrapping Polyplex with a Monolayer of Rationally Designed Block Copolymer for Inter- and Intra-cellular Delivery of siRNA X Ge, T Jin Shanghai Jiao Tong University, China

11:45

Designing Sustained Release Encapsulates loaded with Water Soluble Oxidant: Carbamide Peroxide F L Tchuenbou-Magaia, J Gwyer, N Young, Z Zhang University of Birmingham, United Kingdom

10 Mucus Penetrating Nanoparticles Improve Drug and Gene Delivery to the Gastrointestinal Tract K Maisel, L Ensign, M Reddy, R Cone, J Hanes Johns Hopkins University, U.S.A.

15 Attenuation of High Mobility Group Box 1 Release into Extracellular Milieu by TAT-High Mobility Group Box 1 A Fusion Protein Binding in islet cells Y Hwang, M Lee, D Lee Hanyang University, Korea

End of Session

10:30

Monday

10:45

12:00

End of Session

Cosponsored by Patheon Pharmaceutical Services Inc.

Podium Continental C

Overcoming Biological Barriers

H Chen, A Kim 16 Invited Speaker: Overcoming Macrophage Barriers: 驶Self始 peptides on Nanoparticles, Viruses, and Molecular Therapy D Discher University of Pennsylvania, U.S.A.

D Brayden, M Kastellorizios 21 Invited Speaker: The Biopharmaceutics of Veterinary Drug Delivery S C Sutton University of New England, U.S.A.

Monday

10:30

Boulevard ABC

Mini Symposia: Interspecies Clinical Pharmacology Dosing Concepts

10:45