2011 CRS Annual Meeting Registration Brochure

REGISTRATION MATERIALS 38th Annual Meeting & Exposition of the Controlled Release Society July 30–August 3, 2011 Gaylord National Hotel & Convention Center National Harbor, Maryland, U.S.A. Innovative and Low-Cost Technologies for Healthcare and Consumer Products

Photo courtesy of National Harbor.

Join CRS in National Harbor, Maryland!

Acknowledgments Scientific Secretary Ijeoma F. Uchegbu University of London, U.K. Bioactive Materials Program Chairs Mark Prausnitz Georgia Institute of Technology, U.S.A. Dody Reimer Northern Lipids, Canada Arzu Selen Food & Drug Administration, U.S.A. Consumer & Diversified Products Program Chairs Jamileh Lakkis Lipotec Group, Spain Ronald Versic Ronald T. Dodge Co., U.S.A. Veterinary Program Chairs Marilyn Martinez FDA Center for Vet Medicine, U.S.A. Ramesh Panchagnula Pfizer Pharmaceutical India Pvt., India

Start planning now to join CRS July 30–August 3 at the 38th Annual Meeting & Exposition!

National Harbor is located just 11 miles away from Washington, DC, the U.S. capital, and is home to historic attractions and hundreds of corporate, academic, and government institutions. The scientific program provides the latest research and technical innovations in the areas of medicines, tissue repair, diagnostics, and consumer products.

About the Society CRS is the premier multidisciplinary international society dedicated to promoting the science, technology, and innovation of delivery of actives for the benefit of the world population. CRS serves members from more than 50 countries. The CRS membership is equally representative of industry and academia.

Table of Contents Letter from Scientific Secretary ............................... 3 Educational and Young Scientist Workshops ........... 4 CRS Innovation Sunday ........................................... 7 Program Highlights .................................................. 8 Invited Speakers ..................................................... 14 Networking Opportunities ..................................... 16 Exposition and Sponsorship ................................... 17 Registration Information ........................................ 18 Registration Form .................................................. 19 Gaylord National Hotel & Convention Center ..... 22 National Harbor, Maryland .................................... 23 For updates on the CRS Annual Meeting & Exposition, visit www.controlledreleasesociety.org.

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Letter from the Scientific Secretary Dear Colleagues, These are hardly the best of times but then they are also not the worst of times. The pharmaceutical industry is changing, and change is always painful for some. At CRS we believe in making sure that all of our conference attendees and members have access to as much knowledge Ijeoma F. Uchegbu and networking opportunities as possible so that they can scale this period of immense change relatively unscathed. And scale it we will. Our industry is a high-value industry and, for example, growth in pharmaceutical spending in Organization for Economic Cooperation and Development (OECD) countries grew by 32% between 1998 and 2005 and OECD countries spent approximately 9% of GDP on healthcare in 2009 (www.oecd.org).

Growth in pharmaceutical spending in the BRIC (Brazil, Russia, India, and China) nations is also poised to fuel the future. Add to this the lengthening of life spans, and the future for healthcare innovation is bright, so long as we do not panic and downsize to such an extent that growth actually becomes impossible when spending picks up again.

Innovation is the key to our survival, as well as creating new products to secure animal health and hence food supplies and developing new consumer products that make life just that little bit better and fuel our productivity. We must also begin to look at developing medicines for diseases for which there are currently no cures; diseases such as the spectrum of neurodegenerative diseases which wait expectantly on the horizon to confront an ageing world.

Perry Calias of Shire plc and colleagues have developed an excellent workshop on drug delivery to the brain, an area of great unmet need and an area that merits some attention if we are to address neurodegenerative drug development issues.

Delivering the new wave of biologics that are predicted to bring growth to our industry is another area of real focus. Bill Zamboni of the University of North Carolina and colleagues have designed a workshop as part of a packed CRS Innovation Sunday which focuses on the use of nanotechnology to deliver challenging biologics, such as small interfering ribonucleic acids. Smart and lean will be the watchwords of the future as we will have to develop products outside of the previous blockbuster model and within a pared down resource model. Early engagement with the regulators is one way of slimming down the number of variables to consider, and Arzu Selen of the FDA and colleagues have designed an interactive workshop to debate the regulatory requirements, principally the quality by design parameters, associated with paediatric dosage forms. Look out for an authoritative communiqué, which will be issued after this workshop. A way to create high-value consumer products is in the use of encapsulation technologies, and the workshop developed by James Oxley of the Southwest Research Institute and colleagues will tell attendees all that they need to know to get started on developing such high-value, high-performance products.

This year’s meeting sees some further innovation in the form of an authoritative scientific debate on the issue of transdermal delivery: to pierce or not to pierce—that is the question.

What is the best way to get a medicine into the skin—by micro needle or by femto chemical?

Mark Prausnitz of the Georgia Institute of Technology has designed a super event which should get maximum audience participation. I look forward to this event and to hearing the answer to the question.

A final piece of news about this year’s programme is that there will be an opening ceremony, which CRS President Mark Tracy of Alnyam will be chairing. This event will kick start our conference and get it off to a brilliant beginning.

What a fantastic few days our 38th CRS Annual Meeting & Exposition promises to be.

A stone’s throw from the nation’s capital in beautiful surroundings—the science is almost (note I said almost) a bonus.

Look forward to seeing you all in National Harbor, Maryland.

Ijeoma F. Uchegbu CRS Scientific Secretary www.controlledreleasesociety.org/meeting 3

Educational and Young Scientist Workshops Educational Workshops The following premeeting workshops will be offered at the 38th Annual Meeting & Exposition of the Controlled Release Society. The educational workshops will be held on Saturday, July 30, and Sunday, July 31. Young Scientist Workshops I and II will be held on Saturday, July 30, and Sunday, July 31. All Educational Workshops must be registered for in advance. Please indicate your Young Scientist Workshop attendance on the registration form.

CNS Drug Delivery: From Proof of Concept to Clinical Readiness Saturday, July 30–Sunday, July 31 Chaired by Perry Calias, Shire HGT, U.S.A. Planning Committee: William Banks, University of Washington, U.S.A.; Patti Dickson, Harbor-UCLA Medical Center, U.S.A.; David Jacobson-Kram, FDA, U.S.A.; Mansoor Khan, FDA/CDER/OPS/OTR, U.S.A.; and Anne Pariser, FDA, U.S.A. This workshop is designed to engage you in a multidisciplinary discussion of the comprehensive strategies needed to develop drug and biological products targeted for delivery to the central nervous system (CNS), from drug discovery through to clinical evaluation. The discussion will encompass a review of existing science, determination of existing gaps in knowledge, and strategies to overcome recognized needs.

See #1 on the registration form.

Introduction to Encapsulation and Controlled Release Technologies Saturday, July 30–Sunday, July 31 Chaired by James Oxley, Southwest Research Institute, U.S.A., and Teresa Virgallito, Microtek Laboratories, Inc., U.S.A. This workshop will provide the attendee with a broad overview of the encapsulation and controlled release technologies available, in addition to potential applications. Newcomers to the controlled release field will use this workshop as an introduction to the field, while established members may see this as an opportunity to refresh their knowledge or find ideas outside of their specific area of interest.

See #2 on the registration form.

Interested in Attending a Workshop? Make It a Weekend!

Are you interested in a workshop but not planning to attend the entire annual meeting?

When you register for any Educational or Young Scientist Workshop on Saturday or Sunday, you can attend the original and groundbreaking programming offered at CRS Innovation Sunday for no additional charge. You’ll have access to the Nanomedicine Summit and the Industry Roundtable, as well as any Releasing Technology Workshops or Soapbox Sessions that are not concurrent with your workshop. Plus, you can attend the Exposition Grand Opening/Welcome Reception and Poster Session I on Sunday evening for just $75. You’ll get to know others in the field, have access to hundreds of posters, and meet top industry suppliers. See page 7 for more information on CRS Innovation Sunday programming.

Visit www.controlledreleasesociety.org/meeting for details.

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Pharmacologic and Regulatory Issues for the Translational Development of Nanoparticle Agents Sunday, July 31 Chaired by William Zamboni, UNC Lineberger Comprehensive Cancer Center, U.S.A., and Brian Booth, FDA/CDER/OTS/OCP, U.S.A. This workshop features a comprehensive overview of the ongoing investigations and important issues facing nanoparticle drug development. Sessions will summarize the pharmacodynamics and pharmacokinetics of nanoparticle agents. Significance of size and shape and the overall effects on PK-PD will be detailed. Presentations also will feature insights from preclinical studies in animal models and patients, evaluations of animal models for pharmacologic and toxicologic studies, and profiles of preclinical tumor models for nanoparticle drug development. Analysis concerning tumor-targeting approaches via ligand and antibody labeled carriers will be discussed. Finally, regulatory issues will be addressed by representatives of the FDA. See #3 on the registration form.

Young Scientist Workshops Young Scientist Workshop I: Understanding siRNA Saturday, July 30 Chaired by David Oupicky, Wayne State University, U.S.A.; Patrick Lim Soo, Cerulean Pharma, U.S.A.; and P. Sandhya, Institute of Chemical Technology, India RNA interference (RNAi) is one of the most important discoveries in the field of molecular biology to date. In fact, the pioneering work in this field by Andrew Fire and Craig Mello in the 1990s led to them sharing a Nobel Prize in 2006. The ability to down-regulate genes selectively through RNAi offers the potential to harness a natural mechanism to develop highly specific and important medicines that will revolutionize the way we treat diseases.

Significant progress has recently been made in the treatment of tumors, influenza, high cholesterol, diabetes, and anemia to name a few, with good supporting preclinical data, through the use of RNA interference. This workshop will introduce the audience to the science behind the mechanism of action of RNAi/siRNAs and the applications of this technology to the treatment of a number of diseases. These are exciting times for RNAi therapeutics with scientific and clinical advances being made at a very rapid pace. This is a workshop that all young scientists should not miss.

Program includes: • Introduction to siRNA (history of the field, chemical/biological issues) • Developing siRNAs as therapeutics • Polymer based siRNA delivery • Transdermal delivery of siRNA • Understanding siRNA delivery to the lung • Advances in siRNA delivery to the eye • siRNA and liposomal delivery to tumors • Therapeutic outcome of siRNA delivery for cancer • Panel discussion See #4 on the registration form.

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Educational and Young Scientist Workshops Young Scientist Workshop II: Professional and Self Development for Young Scientists and Protégés Co-organized by Young Scientist Committee and the Young Scientist Mentor/Protégé Subcommittee Sunday, July 31 Chaired by Teresa Virgallito, Microtek Laboratories, Inc., U.S.A., and Padma V. Devarajan, Institute of Chemical Technology, India Trainers: Teresa Virgallito, Microtek Laboratories, Inc., U.S.A., and Buket Aksu, Blanchard International Training Company and Santa Farma Pharmaceuticals, Turkey This workshop is specifically designed to support the all-round career development of young scientists and protégés. The scientific and technical training received in the classroom and laboratory provides only part of the knowledge and skill base required to meet the challenges of professional life in academia and industry. In particular, the ability to manage projects, resources, and yourself are key factors to job success and satisfaction. The objective of this workshop is to help bridge the gap between formal education and the needs of professional life by focusing on three areas vital for career success and self-development.

As part of this workshop you will be introduced to the CRS Young Scientist Mentorship Program. This brief presentation will provide details on the 2011–2012 program, how to join, what is expected from those who enroll in the program, and how you will benefit from participating. Protégé interest forms will be distributed and details on where to find mentor biographies will be announced.

The Program The workshop will cover specific professional and self-development training needed to become a successful project manager/leader. Emphasis will be on project management, motivation, and leadership skills with participants having the opportunity to put new-found knowledge into practice through interactive exercises and games.

• Project management—Training will focus on the four basic elements of a project: resources, time, money, and most importantly, scope.

• Motivation—Training will support young scientists in building and maintaining good morale even in trying circumstances and provide an impetus for positive thinking.

• Leadership—Training will focus on the skills required for young scientists to become able leaders, adept at bringing people together.

The Benefits Participation in the workshop is essential for all young scientists and protégés wishing to develop and hone their professional skills, learn more about themselves and their talents, and obtain new insights into the factors important for career success and satisfaction. So join us to receive training, tips, and ideas to help you with your professional life.

See #5 on the registration form.

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CRS Innovation Sunday Turning Emerging Delivery Science into New Products Science • Partnering • Development • Commercialization Build your networks for success during the second annual CRS Innovation Sunday!

Partnering, technology, innovation, big pharma, entrepreneurs, research, development, regulatory approval, commercialization. You will find all of these elements in the fast-paced programming focused on taking innovative science through development and into the commercial sector. By attending, you will have the opportunity to network with players from multiple areas of controlled release and delivery. Also, CRS Partnering begins on Sunday!

Releasing Technology Workshops Hosted by individual companies, these 1- and 2-hour workshops focus on in-depth facets of products and services supporting research and development in controlled release technologies.

Releasing Technology Workshops (RTWs) are open to all registered attendees.

Agilent Technologies Bend Research Inc. BUCHI Corporation Capsugel - a div. of Pfizer Inc. Catalent Pharma Solutions Celanese

Colorcon Elan Drug Technologies Hanson Research Corporation OctoPlus NV SOTAX Synthonics

Soapbox Sessions The Soapbox Sessions introduce the latest, most novel technologies, products, and services for controlled delivery in bioactive materials, consumer and diversified products, and animal health. Identify new ideas and potential collaborations in these fast-paced presentations and during the one-on-one sessions following the presentations.

Industry Roundtable: Mergers & Acquisitions and Out Licensing This industry roundtable focuses on the various types of mergers and deals that life sciences companies are currently entering into. Presenters will be senior industry executives who have been responsible for securing major agreements with international partners. Why do executives choose particular agreements? How do these decisions support their chosen commercialization path? What lessons did they learn along the way? Learn about the paths these companies have chosen and understand the impact on future requirements toward commercial success.

NEW! Nanomedicine Product Development Summit Turning Nanoparticle Delivery Systems into Innovative Medicines Chairs: Rogério Gaspar, University of Lisbon, Portugal, and Mark Tracy, Alnylam, Inc., U.S.A. Come and participate in panel discussions with leaders in the development, regulatory review and commercialization of nanoparticle-based systems for the delivery of small molecules and siRNA to share experiences and discuss the latest science, challenges, and paths forward in developing new medicines based on nanoparticle delivery technologies.

Be a part of the dialogue to facilitate advancement of these products through the clinic and regulatory approval process.

Exposition Grand Opening and Welcome Reception CRS Innovation Sunday culminates in the Exposition Hall with the Exposition Grand Opening and Welcome Reception. Join 100+ exhibiting companies and more than 1,600 attendees where thousands of products, services, and innovations still to be developed can be discussed one-on-one.

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Program Highlights Plenary Sessions

Gordon Amidon Professor of Pharmacy University of Michigan, U.S.A. Dr. Gordon L. Amidon received his B.S. degree from the State University of New York, Buffalo (1967) and an M.A. degree in mathematics (1970) and a Ph.D. degree in pharmaceutical chemistry (1971) from The University of Michigan. From 1971 to 1981, Dr. Amidon was a member of the faculty at the University of Wisconsin. Dr. Amidon was appointed professor of pharmaceutics at The University of Michigan in 1983 and was named the Charles R. Walgreen, Jr., Professor of Pharmacy in 1994. Dr. Amidon is internationally known for his research in the fields of drug absorption, transport phenomena, solubility and dissolution, and prodrugs. He has published extensively in journals, with more than 300 published papers and 370 abstracts; received 18 U.S. patents; contributed to more than 30 books and monographs; and is co-editor of eight books. Professor Amidon has mentored more than 80 doctoral and post-doctoral students. He has received numerous awards, including best paper awards in the Journal of Pharmaceutical Sciences (1975, 1981, 1984) and Pharmaceutical Research (2004) and the Scheele Award of the Swedish Academy of Pharmaceutical Sciences (1996). He received an honorary doctor of pharmacy degree from the University of Uppsala, Sweden (2001); the Founders Award of the Controlled Release Society (2003); the Volwiler Award of the American Association of Colleges of Pharmacy (AACP) (2004); the American Association of Pharmaceutical Scientists (AAPS) Distinguished Pharmaceutical Scientist Award (2005); the International Pharmaceutical Federation (FIP) Distinguished Pharmaceutical Scientist Award (2006); the Gerhard Levy Distinguished Lectureship (2006); the Alexander von Humboldt Research Award (2009); and the Japan Society for the Promotion of Science ( JSPS) Award (2011). He has organized and participated in many international symposia and workshops. Dr. Amidon developed a Biopharmaceutics Classification System (BCS) with the FDA, impacting bioequivalence standards worldwide. He is a fellow of AAPS, the American Pharmaceutical Association Academy of Pharmaceutical Sciences (APhA/APS), and the American Association for the Advancement of Science (AAAS). He is a member of the Controlled Release Society, serving as president in 1994; AACP; the American Chemical Society (ACS); and AAPS, serving as president in 1998. Professor Amidon is the editor of the ACS journal, Molecular Pharmaceutics.

Henry Brem Chair of Neurosurgery Johns Hopkins Hospital, U.S.A. Dr. Henry Brem has developed new tools and techniques that have changed the field of neurosurgery. He carried out the pivotal clinical study that introduced navigational imaging into the neurosurgical suite. His work led to the FDA’s approval of the first image guidance computer system for intraoperative localization of tumors. Furthermore, he has changed the surgical armamentarium by creating and developing GliadelŽ wafers to intraoperatively deliver chemotherapy to brain tumors. Dr. Brem is the Harvey Cushing Professor of neurosurgery, oncology, and ophthalmology and the director of neurosurgery at Johns Hopkins. He received his undergraduate degree from New York University and his medical degree from Harvard, and he trained in neurosurgery at Columbia. He has built one of the largest brain tumor research and treatment centers in the world. He reinstituted the Hunterian Neurosurgery Laboratory (originally founded by Cushing) and has trained numerous researchers in brain research. Dr. Brem introduced new approaches for targeted therapy for brain tumors. He developed new classes of polymers for drug delivery that are custom synthesized for the agent being developed.

The polyanhydrides, which are the first new treatments for brain tumors that the FDA has approved in 23 years, are biocompatible and potent. Dr. Brem has explored various classes of

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therapeutic agents, including standard chemotherapeutic drugs, new drugs, and chemically modified drugs for better distribution within the brain; the role of antiangiogenesis agents in synergy with chemotherapeutic agents; and this synergistic role of systemic and local treatments for brain tumors. Funding for this research has been through the multi-institutional National Cooperative Drug Discovery Group and from laboratory support from industry and other National Institutes of Health (NIH) grants. Dr. Brem’s teaching was recognized by the Hopkins Professors Award for Excellence in Teaching in 1996. In 1998, he was elected to the Institute of Medicine of the National Academy of Sciences. He has received the Grass Award from the Society of Neurological Surgeons for meritorious research (2000); the Founders Award of the Controlled Release Society (2001); the New York University Distinguished Alumni Award (2004); and the Society for Biomaterials Technology Innovation and Development Award (co-recipient, 2005).

Gordon Muirhead Vice President and Dose Form Leader SDF GlaxoSmithKline, U.K. Gordon T. Muirhead has served in the pharmaceutical industry for 25 years, spending some 17 years in a variety of manufacturing and operational positions and 8 years in research and development, as Director of Clinical Manufacturing and Head of Process Technologies.

Gordon is currently Vice President and Head of the New Product Introduction group within GlaxoSmithKline’s Manufacturing Organization.

Walt Orenstein Deputy Director for Vaccine-Preventable Diseases Gates Foundation, U.S.A. Walter A. Orenstein, M.D., is a deputy director for immunization programs in the Vaccine Delivery Department of the Global Health Program at the Bill & Melinda Gates Foundation. His primary focus at the foundation has been on polio eradication, measles control, and improving routine immunization programs. Between 2004 and 2008, he was a professor of medicine and pediatrics at Emory University, associate director of the Emory Vaccine Center and director of the Emory Program on Vaccine Policy and Development, among other responsibilities. Prior to 2004, he served as a former assistant surgeon general of the United States Public Health Service and director of the National Immunization Program at the Centers for Disease Control and Prevention (CDC), where Dr. Orenstein successfully developed, promoted, facilitated, and expanded new vaccination strategies to enhance disease prevention. Dr. Orenstein has authored and co-authored numerous books, journals, and reviews. Along with Stanley Plotkin, M.D., and Paul Offit, M.D. Dr. Orenstein co-edited Vaccines, 5th edition in 2008—the leading textbook in the field. He is a fellow of the American Academy of Pediatrics, the Infectious Diseases Society of America, and the Pediatric Infectious Diseases Society. In 2006, he was elected to the Institute of Medicine. He is a past chair of the WHO’s Poliomyelitis Technical Consultative Group. Dr. Orenstein received his bachelor of science degree at The City College of New York and his degree in medicine from the Albert Einstein College of Medicine in 1972. He completed an internship and residency in pediatrics at the University of California, San Francisco, and the Children’s Hospital of Los Angeles, followed by a fellowship in infectious diseases at the University of Southern California Medical School. Dr. Orenstein also completed a residency in preventive medicine at the CDC.

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Program Highlights Mini-Symposia The following mini-symposia offer attendees a broad range of topics in controlled release and delivery. CRS has invited the following speakers to present: Biological Research Tools Zhangfeng Cui, Oxford University, U.K. Alison Gurney, University of Manchester, U.K. Sanyog Jain, NIPER, India Andreas Schatzlein, University of London, U.K. Bioresponsive Systems Frank Caruso, Melbourne University, Australia Kazunori Kataoka, University of Tokyo, Japan Rein Ulijn, Strathclyde University, U.K. Ernst Wagner, Ludvick Maximillian University, Germany Cancer Therapeutics Marcel Bally, BC Cancer Agency, Canada Jared Gollob, Alnylam, U.S.A. Aidan Madden, FivePharma Scientific Ltd., Ireland Yoshinobu Takakura, University of Kyoto, Japan Exploiting the Nanoscale to Deliver Poorly Soluble Drugs Elaine Liversidge, Elan, U.S.A. Rainer Müller, Freie University Berlin, Germany Anette Müllertz, University of Copenhagen, Denmark Dody Reimer, Northern Lipids, Canada Microdevices Luc Bousse, QuantaLife Inc., U.S.A. Tejal Desai, University of California-San Francisco, U.S.A. Mark Prausnitz, Georgia Institute of Technology, U.S.A. Shoji Takeuchi, University of Tokyo/CIRMM, Japan Quality by Design and Pediatric Drug Development Gideon Koren, Children’s Health Research Institute, Canada Sam Maldonado, Johnson & Johnson, U.S.A. Diane Murphy, FDA, U.S.A. Robert Skip Nelson, FDA, U.S.A. Jim Polli, University of Maryland, U.S.A. Agnes Saint-Raymond, EMEA, U.K. Arzu Selen, FDA, U.S.A. Catherine Tuleu, University of London, U.K. Helen Winkle, FDA, U.S.A. Janet Woodcock, FDA, U.S.A.

Roundtable Discussions Monday, August 1 Nanomedicine Roundtable—Nanomedicine: From Peripheral Pain to the Bemused Brain Chaired by Dusica Maysinger, McGill University, Canada Topics and Speakers Alzheimer’s Disease: What’s Going On Up There, and Why Are We Having Such a Job Dealing With It?, Jack Diamond, Canadian Alzheimer Society, Canada Nanomedicines for Intra-Articular Delivery to the Temporomandibular Joint, Tony Mikos, Rice University, U.S.A. Oral Drug Delivery Roundtable Chaired by Sarah Eccleston, Encap Drug Delivery, U.K. and Ali Rajabi-Siahboomi, Colorcon, U.S.A. Topics and Speakers To be announced 10

Young Scientist Roundtable—A How-To Guide to Peer Review Speakers: Kinam Park, Editor-in-Chief, Journal of Controlled Release, and Jaap van Harten, Executive Publisher, Elsevier The peer-review process is one of the cornerstones of scientific publishing and is what helps ensure journals have scientific integrity. However, surprisingly, there is hardly any formal training to guide young researchers into becoming a reviewer. Many people have learned through direct experience and even by looking over the shoulder of their supervisor and colleagues. This easy “how-to” workshop is designed to equip you with the insights and tips to enable you to become a better and more fair reviewer. We start with homework…you will be given a real manuscript to review. We then use the workshop to openly discuss and relate your review with that of the other participants. We will then find out what actually happened to the manuscript.

Be sure to join and benefit from: • Valuable insights into the peer-review process • Tips to becoming a better and fairer reviewer • Better understanding of how your own manuscripts are reviewed See #6 on the registration form.

NEW! Special Session Date to be announced AIMBE-CRS Delivery Science, Engineering, and Technology Policy Session: Bottlenecks in Translational Research for FDA-Approved Products Getting a new pharmaceutical or medical device product approved and commercialized is increasingly expensive, which threatens to impact the development of new innovative medical products. This session will focus on the product development process and the key bottlenecks including challenges in tech transfer, regulatory approval, and bridging the “Valley of Death.” Approaches to address these challenges, including public policy aspects, will be discussed. Session will take place on Monday, Tuesday, or Wednesday. Check www.controlledreleasesociety.org/meeting for updates.

CRS Focus Groups Monday, August 1 CRS Focus Groups are specialist subject interest groups in areas relevant to the CRS mission: 1) the delivery of high-quality science in specialist areas, and 2) provide a forum for scientific interactions (electronic or face-to-face) in specialist topics. Focus Groups are headed by one or two scientists, and a dedicated web page is available for Focus Groups to interact and share knowledge on the latest experimental techniques and the latest publications or to simply chat about job vacancies and their careers. Nanomedicines and Oral Drug Delivery Focus Groups will meet immediately following their respective roundtables. Tablet Manufacturing Focus Group is holding only a Focus Group and not a roundtable. Please indicate your attendance on the registration form. Watch the CRS website for the launch of CRS’s newest Focus Group, Ocular Drug Delivery.

Please indicate your attendance on the registration form.

Highlights of Student Posters Tuesday, August 2 Selected graduate students, from reviewed posters, will have the opportunity to highlight their major research contributions. This session is a unique opportunity for attendees to learn about important scientific achievements, as well as support high-quality, promising research by graduate students. www.controlledreleasesociety.org/meeting 11

Program Highlights Pearls of Wisdom Monday, August 1 and Tuesday, August 2 What can you expect during a Pearls of Wisdom session? Just about anything! Controversial topics, outrageous points-of-view, and audience participation are all guaranteed. The debates start off with the presentation of a motion and evidence to support the motion. This is followed by the opponent of the motion presenting counter evidence. Once the presenters conclude, the floor is open to audience participation.

Bioactive Materials/Young Scientists Pearls of Wisdom Speakers to be announced.

Consumer & Diversified Products Pearls of Wisdom Can the Cosmetic Industry Live by Its Tight Regulations?, Peter Reichertz, Sheppard Mullin Richter & Hampton LLP, U.S.A., and Johann Weichers, JW Solutions, The Netherlands Veterinary Pearls of Wisdom Should Drug-Drug Interaction Studies be Required for Chronic Use of Medications in Companion Animals?, Scott Brown, Pfizer, U.S.A., and Mark Papich, University of North Carolina, U.S.A.

Get Up; Get Educated!

Monday, August 1 Clearing the Nanotoxicity Hurdle Chaired by Joshua Reineke, Wayne State University, U.S.A. Speaker: Hamid Ghandehari, University of Utah, U.S.A. Whether you believe nanomaterial safety concerns are hype or a real threat or you are new to the field, this session will be worth getting up for (nanocosmetics optional)! Talks will introduce key issues in nanotoxicity, common methods of analysis, and current and future regulatory concerns. Attend this session and prepare to take your nano-based technology over the nanotoxicity hurdle.

See #7 on the registration form.

Tuesday, August 2 The State of the Art....Vaccines Chaired by Sarah Eccleston, Encap Drug Delivery, Scotland Speaker: Yvonne Perrie, Aston University, U.K. The Young Scientist Committee invites you to rise and shine at this early morning session with Professor Yvonne Perrie as she leads us through the ever-developing field of vaccines. According to the World Health Organization, with the exception of water sanitation, no other modality, not even antibiotics, has had such a major effect on mortality reduction and population growth. Whether you are already an innovator in this field or just want to learn something entirely new about a topical and globally relevant subject, this session will be well worth getting out of bed for!

See #8 on the registration form.

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Young Scientist Mentor/Protégé Meet and Greet Tuesday, August 2 Chaired by Padma V. Devarajan, Institute of Chemical Technology, India, and Mike Rathbone, Griffith University, Australia This is a must-attend session for anyone enrolling in the 2011–2012 CRS Young Scientist Mentorship Program. You will be introduced to your mentor and be given the opportunity to meet face-to-face to discuss how you are going to interact with your mentor over the next 12 months, what your career ambitions are, and what you want out of the program. Attend this meeting and gain your first CRS mentorship experience.

See #9 on the registration form.

CRS Foundation A primary goal of the CRS Foundation is to identify and acknowledge the next leaders for CRS. By providing a catalytic amount of funding and recognition from CRS, the intent is to FOUNDATION accelerate these candidates’ careers in delivery science and create a long-term home for them within CRS. Your contribution to the CRS Foundation helps outstanding award winners realize their potential while supporting the very foundation on which CRS can continue to grow. Please contribute and plan to attend the presentations of the Tsuneji Nagai Postdoctoral Fellowship Award of 2011 and research of the Jorge Heller Postdoctoral Fellow of 2010–2011.

See #19 on the registration form.

Tsuneji Nagai Postdoctoral Fellowship 2011 This new fellowship will be awarded to an outstanding postdoctoral scientist and will honor Professor Nagai, whose work in bioavailability studies and controlled drug delivery formulations has contributed greatly to the pharmaceutical science of Japan, Asia, and the world. Professor Nagai’s distinguished career includes leadership positions at Hoshi University, service on multiple boards, including the CRS presidency, and a body of work that includes three ethical drug products, more than 60 patents, and more than 500 refereed published research papers, resulting in multiple prestigious awards. Beyond measure, he has also influenced students and colleagues whose work continues to significantly impact delivery science. Fellowship applications are accepted through April 1, 2011. The award winner will be announced in early May 2011. Donations can be made on the registration form #19 or online at www.controlledreleasesociety.org/crsfoundation/ Jorge Heller Postdoctoral Fellowship 2010–2011: A Year in Review Tuesday, August 2 CRS Foundation awardee Qun Wang will present outcomes of his fellowship year in the laboratories of Professor Robert Langer at MIT and Professor Jeffrey Karp at Harvard Medical School.

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Invited Speakers The 38th Annual Meeting & Exposition of the Controlled Release Society is pleased to announce the following invited speakers. Topics and speakers are subject to change.

Scientific Sessions – Bioactive Materials Biomaterials

Alberto Bianco, Strasbourg University, France

Clinical Evaluations of Novel Drug Delivery Systems Julie Gehl, University of Copenhagen, Denmark Ron Pettis, BD Technologies, U.S.A.

Delivery to the Brain

David Begley, King’s College, U.K. Kullervo Hynynen, University of Toronto, Canada

Diagnostics

Martin Gijs, EPFL Lausanne, Switzerland Quentin Pankhurst, Royal Institution, U.K.

DNA and RNA Delivery

Kam Leong, Duke University, U.S.A.

Functionalized Nanoparticles

Ronit Satcchi-Fanairo, Tel Aviv University, Israel

Intracellular Delivery

Arwyn Jones, Cardiff University, U.K.

Low-Cost Drug Delivery Solutions Michael Royals, PharmaJet, U.S.A.

Medical Devices

Zhongwei Gu, Sichuan University, China

Microspheres

Mitsuru Hashida, Kyoto University, Japan

Mucosal Delivery (nasal, vaginal, buccal, and rectal) Sevda Şenel, Hacettepe University, Turkey

New Polymer Chemistries

Niren Murthy, Georgia Institute of Technology, U.S.A.

Oncology and Tumor Targeting

Tom Madden, AlCana Technologies, Inc., Canada

Ophthalmic

Henry Edelhauser, Emory University, U.S.A.

Oral Controlled Release

Christian Seiler, Merck, U.K.

Pharmaceutical Manufacturing Alan Royce, Novartis, U.S.A. Bernhardt Trout, MIT, U.S.A.

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Protein Delivery

Steve Schwendeman, University of Michigan, U.S.A.

Pulmonary Delivery

Francis Dayton, Aradigm, U.S.A.

Regenerative Medicine Technologies

Antonios Mikos, Rice University, U.S.A.

Transdermal Delivery—Debate Angstrom vs. Micron James Birchall, Cardiff University, U.K. Jonathan Hadgraft, University of London, U.K.

Vaccines

Istvan Toth, University of Queensland, Australia

Scientific Sessions – Consumer & Diversified Products Advances in Cyclodextrins for CR Applications Helmut Viernstein, University of Vienna, Austria

Characterization of Encapsulated Systems Satya Prakash, McGill University, Canada

Microencapsulation in Cosmetics, Personal, and Homecare Johann W. Wiechers, JW Solutions, The Netherlands

Microencapsulation in Foods, Flavors, and Nutraceuticals Colin Barrow, Deakin University, Australia

Nanoparticles, Nanospheres, and Nanopolymers Simona Margutti, NMI, Germany

Regulations of Microencapsulated Products

Jeff Crowther, Health Products Association, China Sudesh Kamath, FDA Center for Veterinary Medicine, U.S.A. Mansoor Khan, FDA, U.S.A.

Scientific Sessions – Veterinary New Frontiers in Drug Development: Translational Research and Models for Veterinary and Human Health Lepa Antonovic, FDA, U.S.A. Phil Bergman, BrightHeart Veterinary Centers, U.S.A. Ian Blagbrough, University of Bath, U.K. Nick Duesbery, Van Andel Institute, U.S.A. Elaine Ostrander, National Institutes of Health, U.S.A. Satya Prakash, McGill University, Canada

www.controlledreleasesociety.org/meeting 15

Networking Opportunities CRS Partnering Sunday, July 31–Wednesday, August 3

You’re at the CRS Annual Meeting & Exposition to make connections—and this is the tool to help you do just that. CRS Partnering offers one-on-one partnering opportunities to help attendees connect with just the right contact for a project, product, or innovative collaboration.

Open to full-registration attendees (member, nonmember, exhibitor) for an additional $295—or complimentary to one person from an exhibiting company, the user-friendly software facilitates scheduling premeeting appointments with other CRS Partnering participants. Registered participants will be sent details for creating a profile and schedule for appointments online.

See #16 or #17 on the registration form.

First Timers’/Members’ Meeting Sunday, July 31

Learn firsthand how things are going with CRS and where the future will lead. If you have any questions about the society, this is the opportunity to have them answered by the Board of Directors and CRS committee members.

Vet Get Together Monday, August 1

Chaired by Arlene McDowell, University of Otago, New Zealand If you are involved in veterinary controlled release and delivery, interested in animal health, and are keen on being involved in future activities of the Veterinary Committee, you’ll definitely want to attend the Vet Get Together. This is an excellent networking opportunity!

Make sure you’re there!

See #11 on the registration form.

Women in Science Forum Luncheon Monday, August 1

Speaker to be announced.

Come hear an insightful and informative presentation relevant to women in science of all ages and in all disciplines. Visit www.controlledreleasesociety.org/meeting for details.

Advance registration and payment is required. See #12 on the registration form.

Young Scientist Networking Night Organized by the Young Scientist Committee Monday, August 1

Chaired by Sarah Eccleston, Encap Drug Delivery, Scotland, and Joshua Reineke, Wayne State University, U.S.A. Join your colleagues for an after-dinner cruise on the Potomac River. You’ll board a private yacht at the Gaylord National dock and spend two relaxing hours cruising the Potomac, looking at the lights of Old Town Alexandria and, in the distance, Washington, DC. Enjoy a delicious selection of desserts, coffee, tea, and cash bar.

Advance registration and payment are required. See #13 on the registration form.

CRS Party with a Purpose Tuesday, August 2

New! Gaylord’s POSE nightclub is your private nightclub for one fantastical night! Great food, great drinks, great friends, great entertainment and great fun await you. Party the night away while supporting a great cause. After Party admission after 21:30. A portion of ticket and sponsorship sales will go to promote student education in delivery sciences.

Advance registration and payment is required. See #14 and #15 on the registration form.

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Exposition and Sponsorship Come to the Exposition Hall for discovery, solutions, and opportunities. The Exposition is the venue for the business of delivery and profitable collaboration. Come learn the latest advances in delivery and dissolution technologies, instrumentation, equipment, processing innovations, and contract services. Kicking off with the Exposition Grand Opening and Welcome Reception on Sunday, the Exposition/Poster Hall will also be open on Monday, Tuesday, and Wednesday and will serve as the central hub for poster and exhibit viewing, program breaks, and refreshments. Although the Exposition Hall is informally open throughout the day, the dedicated exhibit hours are non-concurrent with the program to allow maximum participation by attendees and exhibitors alike.

The following is a preliminary list of exhibitors as of March 8, 2011. For ongoing updates, please visit www.controlledreleasesociety.org/meeting.

3M Drug Delivery Systems AC Compacting LLC Adhesives Research Agere Pharmaceuticals Agilent Technologies Akina Inc. Analytical Solutions, Inc. Aptuit, Inc. Asahi Kasei Chemicals Corp.

Ashland Aqualon Functional Ingredients Avanti Polar Lipids Aveva Drug Delivery Systems Inc. Bachem Americas, Inc. Banner Pharmacaps Inc. BASF Corp.

Bend Research Inc. BioActs Bio-Images Research Brightwell Technologies Inc. Buchi Corporation Catalent Pharma Solutions Celanese EVA Performance Colorcon, Inc. Corden Pharma Croda Inc. Delta Industrial Services Inc. Depomed, Inc. Dow Chemical Drug Delivery Technology

DURECT Corp/Lactel Absorbable Polymers Elan Drug Technologies Elsevier Erweka GmbH Eurand Pharmaceutical Technologies Evonik Degussa/Pharma Polymers Gateway Analytical Gattefossé Gaylord Chemical Company Glatt Pharmaceutical Services Hanson Research Henkel Corporation InnoCore Technologies IOTA Nanosolutions Limited Lipoid, LLC LTS Lohmann Therapy Systems Lubrizol Advanced Materials, Inc. Microfluidics Mylan Technologies Inc. NAL Pharma Ltd. NanoImaging Services NexMed, Inc. Nisso America Inc. NOF Northern Lipids Inc. Novozymes Biopharma OctoPlus NV Oystar USA Inc.

Patheon Inc. PharmaCircle PharmaForm PII Piramal Healthcare PolyMicrospheres–Advanced Nanotechnologies Polymun Scientific GmbH Polysciences Inc. PURAC Biomaterials SAIC-Frederick, Inc. Scintipharma, Inc. Sensient Pharmaceutical Coating Systems SEPPIC SA Seventh Wave Laboratories Shin-Etsu Chemical Co. Ltd. Simulations Plus, Inc. Sirius Analytical Soliqs Abbott GmbH & Co. KG SOTAX Corp.

Southwest Research Institute Spectrum Laboratories Inc. Springer Surface Measurement Systems SurModics Pharmaceuticals Sympatec Inc. Technology Catalysts Texture Technologies Thermo Fisher Scientific Vector Corporation Wyatt Technology Corporation

Sponsors Make It Happen Many of the annual meeting events are made possible only through the generosity of sponsors.

CRS thanks the following sponsors (current as of March 8, 2011).

Alnylam Pharmaceuticals Banner Pharmacaps Coating Place, Inc. Colorcon Elan Drug Technologies Elsevier Eurand Pharmaceutical Technologies

Fleet Laboratories LTS Lohmann Therapy Systems Merial Microtek Laboratories, Inc. Mylan Technologies Inc. The Nagai Foundation Tokyo Northern Lipids Inc.

Pfizer Ronald T. Dodge Co. Shire Valeo Partners Vision Processing Technologies, Inc.

Become an Exhibitor, Become a Sponsor Contact Debby Woodard, Business Development, at dwoodard@scisoc.org, or +1.651.994.3817, to discuss sponsorship opportunities.

Gain Visibility • Add Value • Support Science • Facilitate Partnering • Promote Networking

www.controlledreleasesociety.org/meeting 17

Registration Information Annual Meeting Registration Annual meeting registration (member, nonmember, exhibitor, and student categories) includes access to the following: CRS Innovation Sunday Sessions Exposition Grand Opening and Welcome Reception Get Up; Get Educated! Sessions Focus Groups Highlights of Student Posters Session

Pearls of Wisdom Sessions Podium and Poster Scientific Sessions Releasing Technology Workshops Roundtable Discussions Soapbox Sessions Young Scientist Events (except as noted)

Tickets must be purchased for all Educational Workshops, the Women in Science Forum Luncheon, the Young Scientist Networking Night, CRS Partnering, and this year’s new event, CRS Party with a Purpose.

Please note that during the registration process you must also indicate your attendance for many of the free workshops and events scheduled throughout the week so that we may plan accordingly. Tickets are limited for some events and early registration is recommended. The deadline for advance annual meeting registration is May 2, 2011.

Exhibitor Registration and Rates Each exhibiting company is entitled to a specified number of complimentary annual meeting registrations. For more information, see the Exhibitor Checklist on the CRS Annual Meeting website. Exhibitors will be provided with separate registration forms so that they may complete their registration.

Member Rates Member rates apply only to current paid members of the Controlled Release Society. Become a member when you register for the CRS Annual Meeting and qualify for exclusive savings.

Full-Time Student/Post-doc Rates Full-time students and post-docs qualify for discounted registration rates. Student nonmembers must have a faculty member sign the registration form to qualify for student rates. Proof of graduate student or post-doctoral research status must accompany student nonmember registration.

Cancellations Cancellations must be made in writing and be received by CRS no later than May 23, 2011.

Cancellations received by this date are subject to a $100 processing fee. Ticketed events will be fully refunded. CRS Annual Meeting & Exposition registration and ticketed event cancellations received after May 23, 2011 are not subject to refund.

Payment Payment must accompany registration. Payment vouchers or purchase orders will not be considered payment.

Payment by Credit Card: Registrations will be charged in U.S. dollars when registering online at www.controlledreleasesociety/org/meeting or by completing the enclosed registration form and sending the form with credit card information via facsimile (+1.651.454.0766) or mail (see address below).

Payment by Check: Registrations must be paid in U.S. dollars (drawn on a U.S. bank) by completing the enclosed registration form and mailing the form and check payment to: CRS Meeting Registration 3340 Pilot Knob Road St. Paul, MN 55121 U.S.A.

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Registration Form Controlled Release Society • 38th Annual Meeting & Exposition July 30–August 3, 2011 Gaylord National Hotel & Convention Center • National Harbor, Maryland, U.S.A. Advance Registration Deadline—May 2, 2011 Register online at http://controlledreleasesociety.org/meeting Complete the following information. Please print clearly to ensure correct spelling on name badge.

Registrant is ❍ Male ❍ Female ❍ Mr. ❍ Mrs.

❍ Ms.

❍ Dr.

❍ Professor

Last/Surname ___________________________________________________________ Name Preferred on Badge (first name only) ___________________________________ Job Title _______________________________________________________________ Date of Birth (new members only) __________________________________________ Month Day Year

Information below is ❍ New Address

❍ Alternate Address

Employer/Company/Institution ____________________________________________ _______________________________________________________________________ Company Address _______________________________________________________ Street

_______________________________________________________________________

_______________________________________________________________________ City

State/Province

_______________________________________________________________________

Zip/Postal Code

❍ Bioactive Materials ❍ Consumer & Diversified Products ❍ Veterinary

Work Category

First Name _____________________________________ Middle Initial __________

Primary Track of Interest

Country

Daytime Telephone ______________________________________________________ Facsimile ______________________________________________________________ E-mail _________________________________________________________________

Hotel Reservations can be made in one of the following ways: 1. Online at www.controlledreleasesociety.org/meeting 2. Telephone Gaylord National direct at +1.301.965.4000. Give the CRS group code: A-CRM11

Must complete reverse side to register.

❍ Academic ❍ Government ❍ Industry ❍ Student ❍ Other __________________________________

Young Scientists ❍ Check here if you are a Young Scientist.

Volunteer Opportunities ❍ Please send information on volunteer opportunities.

New Attendees

❍ I will attend the First Timers’/Members’ Meeting

Special Accommodations ❍ Check here if you require special meals or accommodations to fully participate in this meeting.

Please be specific:

_______________________________________ Mailings ❍ Do NOT include my information in rented mailing lists. ❍ Do NOT include my information in membership directories.

Cancellation/Refund Policy

Cancellations must be made in writing and be received

by CRS no later than May 23, 2011. Cancellations received by this date are subject to a $100 processing fee. Ticketed events will be fully refunded. CRS Annual Meeting & Exposition registration and ticketed event cancellations received after May 23, 2011, are not subject to a refund.

Register by any of these methods Internet: www.controlledreleasesociety.org/meeting Fax: +1.651.454.0766

(Faxed forms must include credit card

information to be processed) Mail: CRS Meeting Registration

3340 Pilot Knob Rd

St. Paul, MN 55121 U.S.A.

Phone: +1.651.454.7250

* Member/Nonmember/Student or Post-doc

Registration Fees Registrations postmarked or faxed by date listed will be charged appropriate fee.

Registration Classifications* Member Student Member Post-doc Member Meeting + Membership Registration + Regular Membership Registration + Student Membership Registration + Post-doc Membership Nonmember Student/Post-doc Nonmember** Exhibitor***

Exhibitor + Membership Sunday Full Day Single Day m Monday m Tuesday m Wednesday

Early

By May 2, 2011 $825 $295 $345

Regular/Onsite Amount After May 2, 2011 $1025 ___________ $385 __________ $435 ___________

$985 $344 $404 $995 $395 $755 $915 $710 $675

$1,185 ___________ $434 __________ $494 ___________ $1,195 ___________ $485 ___________ $995 ___________ $1,155 ___________ $760 ___________ $725 ___________

Educational Workshops—Indicate which workshop (select up to one) you are registering to attend.

Saturday, July 30/Sunday, July 31 1. CNS Drug Delivery: From Proof of Concept to Clinical Readiness 2. Introduction to Encapsulation and Controlled Release Technologies Regular $525 $625 ___________ Student/Post-doc $215 $265 ___________

Sunday, July 31 3. Pharmacologic and Regulatory Issues for the Translational Development of Nanoparticle Agents Regular $275 $375 Student/Post-doc $145 $195

Young Scientist Events—Free for students, post-docs, and/or scientists under 40 years of age or new to the area of controlled release within the past 5 years. Indicate your attendance at one or more of the following events.

4. Saturday Young Scientist Workshop I m 5. Sunday Young Scientist Workshop II m 6. Monday Young Scientist Roundtable m 7. Monday Young Scientist Get Up; Get Educated! m 8. Tuesday Young Scientist Get Up; Get Educated! m 9. Tuesday Mentor Protégé Meet and Greet m

Additional Event Tickets—All Attendees 10. Extra Opening Reception Ticket 11. Vet Get Together 12. Women in Science Forum Luncheon 13. Y. S. Networking Night Potomac River Cruise 14. CRS Party with a Purpose (includes After Party) 15. CRS After Party Admission

___________ ___________

CRS Focus Groups—Indicate your intent to attend one or more of the following: Monday m Nanomedicines m Oral Drug Delivery m Tablet Manufacturing

Travel Grant Contribution Contributions support graduate student travel to annual meeting.

18. Contributions of $25 or more receive print acknowledgments.

CRS Foundation Contributions support CRS programs and Foundation Fellowship.

19. Donations of $100 or more receive print acknowledgments.

Sunday Full Day fee includes all Young Scientist events (except as noted), Releasing Technology Workshops, Innovation Sunday Sessions, Soapbox Sessions, First Timers’/ Members’ Meeting, and the Exposition Grand Opening and Welcome Reception.

Quantity Amount ___________ $75 ___________ ___________ $0 ____N/C___ ___________ $25 ___________ ___________ $50 ___________ ___________ $95 ___________ ___________ $20 ___________

CRS One-on-One Partnering Sessions 16. Open only to attendees with regular full or single day registration 17. Complimentary Exhibitor (one per exhibiting company)

Member or Nonmember/Meeting + Membership/Exhibitor fees include all Roundtable Discussions, Releasing Technology Workshops, Soapbox Sessions, Young Scientist events except as noted), Pearls of Wisdom Sessions, Highlights of Student Posters Session, First Timers’/Members’ Meeting, Get Up; Get Educated Sessions, Exposition Grand Opening and Welcome Reception, Innovation Sunday Sessions, Podium and Poster Scientific Sessions, and Exposition. Tickets must be purchased for all educational workshops; the Women in Science Forum Luncheon ($25), the Young Scientist Networking Night ($50), the CRS Party with a Purpose ($95), and the After Party ($20).

$295 $0

___________ ____N/C___

Contribution ___________ Contribution ___________ Total ___________

Single Day (Monday/Tuesday/Wednesday) fee includes access to the Young Scientist events (except as noted), Get Up; Get Educated Sessions, Highlights of Student Posters; Podium and Poster Scientific Sessions, Roundtable Discussions, Focus Groups, Pearls of Wisdom, and the Exposition. Tickets must be purchased for the Women in Science Forum Luncheon ($25), the Young Scientist Networking Night ($50), the CRS Party with a Purpose ($95), and the After Party ($20).

Educational Workshop fees include a workshop notebook, lunch (Saturday only), morning and afternoon breaks, and Saturday networking reception. **

Student and/or Post-doc Nonmembers must have a faculty member sign to qualify for the Student or Post-doc Nonmember registration fees and to receive Student/Post-doc rates for ticketed events. This information will be verified

by CRS. Nonmember Students/Post-docs must register via fax or mail to receive this rate.

________________________________________

Advisor Name

________________________________________

Advisor E-mail

*** Each exhibiting company is entitled to a

specified number of complimentary annual meeting registrations. See the exhibitor checklist on the annual meeting website for more information.

Payment Information ❍ Check enclosed, payable to CRS (U.S. funds only drawn from a U.S. bank) When you provide a check as payment, you authorize us to use information from your check to make a one-time electronic fund transfer from your account or to process the payment as a check transaction.

Funds may be withdrawn from your account the same day we deposit payment and you may not receive your check back from your financial institution.

❍ Charge: ❍ VISA

❍ American Express ❍ MasterCard

Card No. _ _____________________________________________________________________ Expiration Date ___ ___ /___ ___ Cardholder Name (please print) __________________________________________________ Cardholder Signature __________________________________________________________

Attire and Weather Business casual is the recommended dress for the CRS Annual Meeting & Exposition.

The average late July/early August high temperature in National Harbor is 89°F (32°C) with high humidity. The average low temperature is 74°F (23°C).

Emergency Information If you have a medical condition that CRS should be aware of during the meeting, please fax your information to CRS Annual Meeting & Exposition, +1.612.813.0364, or e-mail lbarna@scisoc.org. This information should be received no later than May 17, 2011, and is optional.

Your information will not be shared with anyone, except in case of emergency, and then only with emergency personnel.

ADA/Special Requests For full and equal enjoyment of the CRS Annual Meeting & Exposition, please specify any special requirements you may have in the “Special Accommodation” area of the registration form, and a CRS staff person will contact you to further discuss your needs.

Meeting Overview The CRS Annual Meeting & Exposition begins with premeeting Educational and Young Scientist Workshops on Saturday and Sunday. CRS Innovation Sunday activities include Releasing Technology Workshops, Soapbox Sessions, First Timer’s/Member’s Meeting, and the Nanomedicine Product Development Summit. Tickets to Sunday’s Exposition Grand Opening and Welcome Reception are available for $75. Plenary Sessions, Scientific Sessions, and Mini-Symposia are scheduled Monday through Wednesday from 08:00 through 17:00.

The Exposition and Poster Hall is open starting Sunday evening, closing Wednesday at 12:00.

View the complete meeting schedule at www.controlledreleasesociety.org/meeting/program.

Program Modifications All information is subject to change without notice.

Official Language English is the official language of the CRS Annual Meeting & Exposition.

Photo Release Many photographs will be taken throughout the CRS Annual Meeting & Exposition and are used in CRS electronic and printed promotional materials during the meeting and after it has concluded. By virtue of your attendance, you agree to the Controlled Release Society’s use of your likeness in said promotional media.

www.controlledreleasesociety.org/meeting 21

Gaylord National Hotel & Convention Center CRS Headquarters Hotel The Gaylord National Hotel & Convention Center is the headquarters hotel for all CRS Annual Meeting & Exposition meetings and events (unless otherwise noted).

Gaylord National’s Location and Closest Airports Gaylord National Hotel & Convention Center, the cornerstone of the new 300-acre National Harbor, is the largest combined convention center and hotel on the East Coast. Gaylord National is conveniently located 15 minutes south of Washington, DC, just off of the Capital Beltway (I-95/I-495), in National Harbor, Maryland. The two closest airports to Gaylord National are Reagan National Airport (DCA) and Washington Dulles International Airport (IAD).

Gaylord National provides transportation to/from Reagan National Airport and hourly shuttle service to/from Washington, DC. Gaylord National is steps from the sparkling waterfront of National Harbor, featuring a myriad of shopping and dining opportunities.

Gaylord National Hotel and Guest Room Amenities Gaylord National’s soaring 18-story, 1.5-acre, glass-covered atrium offers stunning views of the Potomac River and Old Town Alexandria. Seven distinctive restaurants and eateries provide a variety of dining experiences for all tastes. The 20,000-square-foot, world-class Relâche Spa & Salon offers the following: men’s and women’s saunas, steam rooms, co-ed tea/ relaxation lounge, state-of-the-art fitness center, unique indoor/outdoor pool, and luxurious spa services. Valet parking, tour desk, business center, and onsite Hertz car rental round out Gaylord National’s impressive list of amenities and services.

CRS Discounted Nightly Rates—Run of House Rooms (except suites) Single/Double Occupancy $245 plus tax and $10 resort fee (1 to 2 persons) Triple/Quad Occupancy $265 plus tax and $10 resort fee (3 to 4 persons) CRS discounted room rates are applicable three days pre- and post-annual meeting dates based on availability. Breakfast is not included. Gaylord National Hotel & Convention Center is a smoke-free facility.

Your resort fee includes the following amenities: • USA Today delivered every weekday morning (Washington Post delivery on weekends) • In-room high-speed Internet access • Wireless Internet access in the guest rooms, dining outlets, and atriums • Fitness center access • 2 bottles of water per day in guest room • Local phone calls (first 20 minutes per call) • 800-access and toll-free calls (first 20 minutes per call) To Book Your Gaylord National Hotel Room / Reservation Deadline The deadline for booking your Gaylord National Hotel reservation at CRS discounted rates is Friday, July 8, 2011. Reservations received after this date cannot be guaranteed the CRS discounted rates.

Hotel reservations may be made by one of the following methods: 1. Online: www.controlledreleasesociety.org/meeting. Click on link provided for Gaylord National Hotel & Convention Center.

2. Telephone: Call hotel direct at +1.301.965.4000. Give the CRS group code: A-CRM11.

A deposit of one night’s room and tax is required to confirm your hotel reservation. Deposits are only refundable for cancellations occurring three days prior to arrival. To assist CRS in keeping annual meeting registration fees affordable and meeting expenses low, attendees are asked to book with Gaylord National Hotel & Convention Center.

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National Harbor, Maryland, U.S.A. Join your CRS colleagues in beautiful National Harbor!

National Harbor, Maryland, is located 11 miles south of Washington, DC, and a scenic water taxi ride across the Potomac to historic Old Town Alexandria, Virginia.

BWI Air port

Maryland Washington,D. C. FedEx Field

•

Georgetown

Alexandria Woodrow Wi lson Br idge

•

Six Flags America

•

R IV ER

Virg inia

•

PO TO MA C

Dulles Intl.

Air port

Union Station • • ArlingtonWhite House National • U. S. Capitol Cemetery • • Nationals Stadium Pentagon • • Reagan National Air port

National Harbor (15 minutes to Reagan National Airport)

National Harbor is directly accessible from the Capital Beltway, I-95, I-495, I-295, the Woodrow Wilson Bridge, and is minutes away from area airports. There are interchange and multi-lane fly-off ramps exiting exclusively into the community from Maryland, Virginia, and DC.

National Harbor, Maryland Familiar U.S. retailers and unique local boutiques line this bustling urban town center, filled with pedestrian-friendly plazas, tree-lined walkways, and colorful streetscapes. National Harbor’s waterfront and marina backdrop completes the perfect setting for dinner cruises, water taxi rides, outdoor dining, and entertainment opportunities.

Washington, DC—the U.S. Capital Washington, DC’s Metro is one of the world’s best public transportation systems providing a quick, convenient, and affordable way to get around the city. Many of Washington, DC’s major attractions are open to the public, free-of-charge, and do not require tickets, including the National Zoo, National Portrait Gallery, Library of Congress, the U.S. Supreme Court, Ford’s Theatre, the Smithsonian Institution museums, and the national monuments and memorials located on or near the National Mall.

Historic Old Town Alexandria, Virginia Alexandria, Virginia, is located just 5 miles away from National Harbor and is easily accessible by water taxi from Gaylord National. The free King Street Trolley will take you to the antique shops and contemporary art galleries that line the cobblestone streets of this neighborhood once home to George Washington and Robert E. Lee. For websites and detailed information on National Harbor, Washington, DC, and Old Town Alexandria attractions, visit the CRS Annual Meeting website at www.controlledreleasesociety.org. www.controlledreleasesociety.org/meeting 23

July 30–August 3, 2011 Gaylord National Hotel & Convention Center National Harbor, Maryland, U.S.A.

38th Annual Meeting & Exposition of the Controlled Release Society

Register Today!

Controlled Release Society 3340 Pilot Knob Road St. Paul, MN 55121 United States of America