Insights into genetic research

25 Year 11 IB and 12 ATAR students visited the BioDiscovery Centre, a purpose-built facility to support the learning of biotech skills via real-world experience.

The purpose of the excursion was to give students a deeper understanding of how mutations can be identified through PCR, gel electrophoresis and sequencing in interactive wet and dry lab activities. This learning supports their understanding of the biotechnology studied as part of the Biology ATAR and IB curriculum. The tour was conducted by Masters and PhD students, who are currently doing research at the Harry Perkins Institute.

Year 12 student, Alec Aubé, takes us through the experience.

The tour began with an informative introductory presentation by the institute’s researchers. They introduced us to some of the methods they apply to detect genetic inferences of cancer such as carcinogens, which are most pertinent in causing cancer, and how to protect ourselves from common mutagens.

We were first introduced to the methodologies for detecting genetic indicators of cancer, specifically the melanoma variant, and then

taken through the process of how sampling DNA is replicated via artificial mitosis. The replicated DNA is then processed through a machine to detect any mutations. This indicates whether the individual whose DNA is being sampled is a suitable candidate for specific targeted treatment.

We were then tested on our active memory retention skills through a competition. We were split into groups of 2 or 3 and assigned the responsibility of performing a dry lab polymerase chain reaction using the four enzymes involved in replicating DNA: Taq polymerase, helicase, ligase, and primase. The groups were given simulated components of genetic information made of paper. However, the real challenge was having to create certain parts of the PCR cycle within a set time frame; the amount of DNA replicated doubled from each round.

The concepts of recent and upcoming developments regarding cancer research, one of many domains the Harry Perkins Institute applies itself to, were then illustrated to the group. The research in the field of cancer research is ever advancing, with treatment moving away from radiation, which has detrimental side effects. More recently, researchers across the globe are utilising methods such as CAR T-cell immunotherapy

The visit concluded with an informative tour of the institute. The volunteers guided us around the Institute, displaying the equipment utilised in the process of cancer detection, the costs leaving us in disbelief.

Overall, the visit enlightened us to the amazing advancements and lab work which is being made by researchers at the centre and world-wide.

Alec Aubé Year 12