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ENDORET (PRGF)
Dermatology & Aesthetics
From Globe to Pakistan
One Step Ahead in PRP
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins R
ENDORET (PRGF)
Convenient 3-step Therapy
ENDORET stimulates tissue regeneration due to growth factors, in greater concentrations than those of blood*
*Anitua E, SĂĄnchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, AndĂa I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42:162-170
One Step Ahead in PRP
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins R
ENDORET (PRGF)
Enables Fibrin Matrix to release Growth Factor gradually for
Prolonged Clinical Efficacy
1,2
ENDORET Technology reduces the tissue repair time RESPONSE OF THE TISSUES
NATURAL WOUND-HEALING PROCESS HAEMOSTASIS INFLAMMATION PROLIFERATION
HEALING PROCESS ACCELERATED WITH ENDORET
REMODELLING
REDUCTION IN RECOVERY TIME
1-Sánchez M, Anitua E, Azofra J, Andía I, Padilla S, Mujika I. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 2007;35:245-251. 2- Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14:529-535.
One Step Ahead in PRP
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins R
ENDORET (PRGF)
p<0.5 100,000
ENDORET increases proliferation of cells & improves secretion of Pro-collagen
80,000 60,000
1,2
40,000 20,000
CONTROL ENDORET
1- Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009 Apr;42(2):162-170. 2- Blanca Díaz Ley. Efectos del PRGF en el tratamiento del envejecimiento cutáneo. Comunicación oral de la XXV reunión GEDET. Alicante 29-30 Noviembre 2013.
ENDORET significantly increases production of endogenous Hyaluronic Acid 1,2
CONTROL
ENDORET
1- Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009 Apr;42(2):162-170 2- Anitua E, Troya M, Orive G. Plasma rich in growth factors promote gingival tissue regeneration by stimulating fibroblast proliferation and migration and by blocking transforming growth factor-•'E21- induced myodifferentiation. J Periodontol. 2012 Aug;83(8):1028-1037.
One Step Ahead in PRP
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins
Tailor your Own Formulation of Liquid
R
ENDORET (PRGF) Clot
Graft
Membrance
Wide Spectrum of Applications
DERMATOLOGY Wound Healing Burns Chronic Ulcers Pressure Ulcers Venous Ulcer Sicke-cell Disease Ulcers
ENDORET accelerates the inflammatory process, decreases pain and increases the reepithelialised area in wounds 1,2
1- Anitua E, Troya M, Orive G. Plasma rich in growth factors promote gingival tissue regeneration by stimulating fibroblast proliferation and migration and by blocking transforming growth factor-•'E21- induced myodifferentiation. J Periodontol. 2012 Aug;83(8):1028-1037. 2- Molina-Miñano F, López-Jornet P, Camacho-Alonso F, Vicente-Ortega V. The use of plasma rich in growth factors on wound healing in the skin: experimental study in rabbits. Int Wound J. 2009 Apr;6(2):145-148.
One Step Ahead in PRP
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ENDORET (PRGF) Wide Spectrum of Applications
AESTHETICS
WRINKLES AND LINES
Forehead Lines Glabellar Region Crowâ&#x20AC;&#x2122;s Feet Lip Wrinkles Nasolabial Fold Marionette Line Eye Circles Jaw Line Neck Wrinkles
LIP REJUVENATION
HAIR RESTORATION
ACNE SCARS DECOLLETAGE
STRETCH MARKS
ENDORET can also be used in combination with HA Fillers, Micro-needling, Chemical Peel, Laser Resurfacing & other aesthetic procedures One Step Ahead in PRP
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins R
ENDORET (PRGF) MATERIALS CONTAINED IN EVERY SINGLE USE KIT BLOOD EXTRACTION SYSTEM ..........................................
2 Extraction Tubes 1 Blood Extraction Butterfly
FRACTIONATION SYSTEM ..........................................
2 Fractionation Tubes 1 PTD2 (Plasma Transfer Device) 2 Fine-ject 14G Needles
.........................
APPLICATION SYSTEM
1 Activation Ampoule (Calcium Chloride) 1 Activation Syringe (BD Microfine 0.5 ml) 2 BD 3 ml Syringes 2 Fine-ject 21G Needles 2 Sterican 30G Needles & Meso-Relle 32G 5 ID Labels
SPAIN
One Step Ahead in PRP
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins R
ENDORET (PRGF) 100% AUTOLOGOUS - Patients own blood ensures no Adverse Effects1 LEUCOCYTE-FREE FORMULATION - No Pain & Inflammation2 OPTIMUM LEVEL OF PLATELETS - Excellent Clinical Response3 CONTROLLED ACTIVATION - Maintains Prolonged Efficacy 4
Over 200 International Scientific Publications
LEADER IN REGENERATIVE MEDICINE
SPAIN
More than 40 scientific collaboration agreements with universities and research institutes all over the world. 20% of the workforce dedicated to research. More than 15 years of research in tissue regeneration. Prince Felipe Award for Technological Innovation.
Over 1000,000 Patients treated in 20 Countries www.endoret.com REFERENCES
Marketed by:
1- Anitua E, Sá'E1nchez M, Nurden AT, Nurden P, Orive G, Andí'EDa I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24:227-234. 2- Filardo G, Kon E, Pereira Ruiz MT, Vaccaro F, Guitaldi R, Di Martino A, Cenacchi A, Fornasari PM, Marcacci M. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2012. 3- Anitua E, Sanchez M, Prado R, Orive G. The type of platelet-rich plasma may influence the safety of the approach. Knee Surg Sports Traumatol Arthrosc. 2012. 4- Anitua E, Sanchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G, Azofra J, Andia I. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A. 2006;77:285-293.
One Step Ahead in PRP