ENDORET
R
(PRGF)
One Step Ahead in PRP
According to the Wound Healing Society, about 15% of older adults in the US suffer from chronic wounds, including predominantly venous stasis ulcers, pressure ulcers (bedsores), and diabetic (neuropathic) foot ulcers.
Worldwide, it is estimated that a lower limb is lost every 30 seconds as a result 1 of diabetic wound infection ulcers related to venous insufficiency constitute 70%, arterial disease 10%, and 2 ulcers of mixed etiology 15% of leg ulcer presentations
4 PHASES OF WOUND HEALING
Chronic Wounds usually stall in the Inflammatory Phase 1- C. F. Cheng, D. Sahu, F. Tsen et al., “'93A fragment of secreted Hsp90•'2E•'2E carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice,”'94 The Journal of Clinical Investigation, vol. 121, no. 11, pp. 4348–'964361, 2011
2- G. Casey, “'93Causes and management of leg and foot ulcers,”'94 Nursing Standard, vol. 18, no. 45, pp. 57–'9658, 2004
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ENDORET
R
(PRGF)
ROLE OF GROWTH FACTORS IN HEALING THE NEW TREND
PLASMA & GROWTH FACTORS ARE EXTRACTED AUTOLOGOUSLY FROM PATIENT’S OWN BLOOD WHICH AID IN HEALING OF CHRONIC WOUNDS, ULCERS & BRUNS
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ENDORET
R
(PRGF)
The Biomedical Technology to Stimulate Tissue Regeneration through Autologous Proteins
Convenient 3-step Therapy
ENDORET stimulates tissue regeneration due to growth factors, in greater concentrations than those of blood*
*Anitua E, SĂĄnchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, AndĂa I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42:162-170
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ENDORET
R
(PRGF) 1,2
ENDORET Technology reduces the tissue repair time RESPONSE OF THE TISSUES
NATURAL WOUND-HEALING PROCESS HAEMOSTASIS INFLAMMATION PROLIFERATION
HEALING PROCESS ACCELERATED WITH ENDORET
REMODELLING
REDUCTION IN RECOVERY TIME
Enables Fibrin Matrix to release Growth Factor gradually for
Prolonged Clinical Efficacy
1-Sánchez M, Anitua E, Azofra J, Andía I, Padilla S, Mujika I. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 2007;35:245-251. 2- Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14:529-535.
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ENDORET
R
(PRGF)
p<0.5 100,000
ENDORET increases proliferation of cells & improves secretion of Pro-collagen
80,000 60,000
1,2
40,000 20,000
1- Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009 Apr;42(2):162-170. 2- Blanca Díaz Ley. Efectos del PRGF en el tratamiento del envejecimiento cutáneo. Comunicación oral de la XXV reunión GEDET. Alicante 29-30 Noviembre 2013.
CONTROL ENDORET
ENDORET significantly increases production of endogenous Hyaluronic Acid 1,2
CONTROL
Liquid
Clot
ENDORET
Graft
Membrance
1- Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009 Apr;42(2):162-170 2- Anitua E, Troya M, Orive G. Plasma rich in growth factors promote gingival tissue regeneration by stimulating fibroblast proliferation and migration and by blocking transforming growth factor-•'E21- induced myodifferentiation. J Periodontol. 2012 Aug;83(8):1028-1037.
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ENDORET
R
(PRGF)
MATERIALS CONTAINED IN EVERY SINGLE USE KIT BLOOD EXTRACTION SYSTEM ..........................................
4 Extraction Tubes 1 Blood Extraction Butterfly
FRACTIONATION SYSTEM ..........................................
2 Fractionation Tubes 1 PTD2 (Plasma Transfer Device) 4 Fine-ject 14G Needles
...............
APPLICATION SYSTEM
1 Activation Ampoule (Calcium Chloride) 1 Activation Syringe (BD Microfine 0.5 ml) 5 ID Labels
SPAIN
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ENDORET
R
(PRGF)
Applications in Surgery & Reconstructive Surgey
CHRONIC ULCERS, WOUNDS & BURNS 100% AUTOLOGOUS - Patients own blood ensures no Adverse Effects1 LEUCOCYTE-FREE FORMULATION - No Pain & Inflammation 2 OPTIMUM LEVEL OF PLATELETS - Excellent Clinical Response3 CONTROLLED ACTIVATION - Maintains Prolonged Efficacy 4
Over 200 International Scientific Publications
LEADER IN REGENERATIVE MEDICINE
SPAIN
More than 40 scientific collaboration agreements with universities and research institutes all over the world. 20% of the workforce dedicated to research. More than 15 years of research in tissue regeneration. Prince Felipe Award for Technological Innovation.
Over 1000,000 Patients treated in 20 Countries www.endoret.com REFERENCES
Marketed by:
1- Anitua E, Sá'E1nchez M, Nurden AT, Nurden P, Orive G, Andí'EDa I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24:227-234. 2- Filardo G, Kon E, Pereira Ruiz MT, Vaccaro F, Guitaldi R, Di Martino A, Cenacchi A, Fornasari PM, Marcacci M. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2012. 3- Anitua E, Sanchez M, Prado R, Orive G. The type of platelet-rich plasma may influence the safety of the approach. Knee Surg Sports Traumatol Arthrosc. 2012. 4- Anitua E, Sanchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G, Azofra J, Andia I. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A. 2006;77:285-293.
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