Five Upcoming Trends Within Cardiovascular Research
Over the past several years, many changes took place in the treatment of cardiovascular (CV) disease, which resulted in marked decline in rates of morbidity and mortality. In this article we write about 5 emerging trends within drug research sector are highlighted each reinforces the need for therapeutically centric, methodologically strenuous, and highly efficient project teams for product assessment and commercialization. These trends are:
To recognise pleiotropic drug effects
Initiation of personalized/precision medicine
Effect of epigenetic and miRNA antisense oligonucleotide therapeutics
Development of Interventions;
Academic, CRO, and pharma collaboration
innovative
trial
methods
for
innovative
1) CV Research in Pleiotropic Age Drugs treating metabolic faults like dyslipidemias and type 2 diabetes mellitus are on the current scenario of treatments which defined multiple effects assumed under the concept of “pleiotropy”. The impact of type II diabetic therapy on the CV system prompts concern and look after. The most recent target is the enzyme dipeptidyl peptidase 4 (DPP-4). 2) Personalized Treatment Personalized medicine gained success in oncology, but it faces various challenges in CV disease where complex genetics, environment and patient lifestyle comes together to create a unique clinical presentation for each patient. It is more than a simple genotype, but interplay of environmental factors with patient risk factors that directs therapeutic decisions, and hence factors which either confound or mediate beneficial therapeutic effects. The several interplay of genes and environmental says that novel therapies might work extremely well, but only in a few.
3) Epigenetics Therapeutics
and
MiRNA
Antisense
Oligonucleotide
The amount of basic science research involving epigenetic effects on RNA biology has expanded with knowledge of their role in progress and prevention of disease. Scientific discoveries with epigenetic changes in DNA methylation, histone modification, and RNA biology affects the CV system and is creating the potential for
new therapeutic avenues. 4) Innovative Trial Methods There is an emphasis about the necessity of re-evaluating traditional trial designs and methods of execution. Even if trials might not differ in treatment intervention, eligibility criteria, or imaging assessments, it is commonly observed that patient response in different geographical regions could exhibit marked variation. 5) A natural extension of the science Basic research, drug discovery and drug development are too often viewed as being at different ends of a research and development process. But the fact is that they are complementary and enmeshed. CRO serves as a mediator of the process should exemplify an ability to manage, facilitate, and support the interests of various stakeholders and thus transforms the way clinical research can be conducted.
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