In this issue, we focus on digital transformations—not only on how digitization is transforming our society but also how our society is shaping the power of digitization. From the role of AI in the arts and music to leveraging sophisticated algorithms for deciphering viral proteins, this issue provides an expansive overview through multiple lenses. Furthermore, we touch on topics like the Internet of Things (IoT), open-source artificial intelligence, and the deeper societal implications of automation. We hope that when you read this issue, you feel enthralled, alarmed, and above all, excited about the future of digitization. Happy reading!