A4M MMI | Anti-Aging Medical News - Winter 2022

Dear Colleagues,

Welcome to the 30th Annual World Congress: LongevityFest 2022, presented by the American Academy of AntiAging Medicine (A4M). Our organization celebrates 30 years of providing best-in-class, innovative medical education this year. In 1992, when we founded the Academy, we were just two people with the vision of a better future for physicians, patients, and healthcare in its entirety.

Here we stand 30 years later: a global community of innovators and visionaries who work continuously to redefine modern medicine. Our mission has always been to maintain the status as the leader in delivering transformative education that assists forward-thinking practitioners in shaping the medicine of tomorrow. We are honored to celebrate this anniversary with you as we look back at our past with pride and move forward with a clear vision of an even better future.

We gather here at the pinnacle of the longevity movement, where we will examine the future of medicine together. We will look at what it means for our health and longevity and how we can harness new technologies to improve our collective health outcomes. As we highlight the latest and most impactful advancements in longevity medicine and future-focused, purpose-driven health care, the coming three days will deliver an unmatched immersive educational experience.

Starting Thursday with a selection of timely pre-conference workshops, the LongevityFest agenda opens with detailed investigations of hyperbaric medicine, nitric oxide, and lifestyle-based hormone optimization. LongevityFest officially commences on Friday with sessions led by renowned anti-aging experts and a keynote presentation by distinguished innovator Peter Diamandis, MD.

The three-day event will feature highly impactful sessions led by a collection of the industry’s top visionaries. Attendees will have the opportunity to hear from luminaries such as Jeffrey Bland, PhD, Ken Dychtwald, PhD, and Clint Pulver about cutting-edge research in various fields pertaining to longevity and quality of life. From presentations about stress resilience, neuroinflammation, and immuno-rejuvenation to lectures on understanding cellular senescence and cellular stress responses, our world-class speakers will provide attendees with a wide variety of perspectives, clinical insights, and protocols to improve human health- and lifespan.

LongevityFest will be filled with excitement and wonder—but most importantly, it will help us continue our mission: to inspire health professionals to provide future-focused, whole-person care and advance the practice of medicine.

On behalf of the entire A4M team, we would like to express our sincere gratitude to each of you for bringing your acumen, vision, and dedication to this event. Thank you to those who have accompanied us on our journey for the past 30 years; your support has led to a profound positive impact on so many lives. To all first-time event attendees, we extend a warm welcome to the world of A4M, and we hope you will continue to join us for future educational experiences. Please enjoy your stay in Las Vegas and have a safe journey back home.

In Good Health And Toward A Brighter Future,

Ronald Klatz, MD, DO & Robert M. Goldman, MD, PhD A4M Founders

Ronald Klatz MD, DO Co-Founder

Robert Goldman MD, PhD, DO, FAASP Co-Founder

SHOW REGULATIONS

1. An official picture ID is required to pick up name badge.

2. Name badge must be worn at all times during show hours and official events.

3. No one under the age of 18 will be admitted into the Exhibit Hall.

4. This event is open to healthcare professionals and their invited guests only.

5. Photography is permitted in the Exhibit Hall only by press, with the prior permission of show management, and prior permission from the firm(s) whose booth(s) are being photographed. Videography in the Exhibit Hall (motion video, film, or digital) is permitted only at discretion and with advance permission of show management and the prior permission of individual(s) and/or firm being photographed.

6. Audio and video recording (tape or digital) of this event is expressly prohibited.

7. Unauthorized solicitation is prohibited. In addition, non-A4M and/or commercial literature of any kind may not be distributed near or at the event registration area and all event-related general public areas.

8. No medical procedures are permitted to take place in Exhibit Hall booths without prior permission of show management.

9. Show management reserves the right to expel any individual and/or company without recourse or refund at its sole discretion.

10. PHOTO RELEASE: Anyone in attendance at any A4M event may be subject to any photography or videography conducted during the event which may be used in any form for future media purposes. Please contact A4M with any concerns.

The American Academy of Anti-Aging Medicine (A4M.) All rights reserved. ISSN 1533-6700. AntiAging Medical News publishes materials in good faith and makes no claims or endorsements for products, services or procedures that appear in the publication. Opinions expressed in articles and advertisements are not necessarily those of Anti-Aging Medical News, its owners, affiliates, or its staff. The publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Under no circumstances is the content of Anti-Aging Medical News to be construed as medical advice. Always consult your personal physician prior to beginning a new therapy, or changing any current regimen.

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A Diverse and Unique Microbiome May Be the Secret to Healthy Aging

By: Microbiome Labs

By: Min Wie, PhD & James Kelley, PhD

By: Jason Sonners, DC, DCBCN, PhD(c)

By: Jocelyn Strand, ND - Director of Clinical Education, Biocidin®

By: Mitchell J. Ghen, DO, PhD, Claudia Hanau, NMD, Carsten Evans, PhD, Irena Ghen, MSN, APRN-C

By: Lindsay Christensen, MS, CNS, LDN

Fellowship in Anti-Aging, Metabolic and Functional Medicine (FAAMFM)

A REDEFINED APPROACH TO FUNCTIONAL MEDICINE

Transform your approach to patient-care, and ultimately the trajectory of your clinical career, through the Fellowship in Anti-Aging, Metabolic and Functional Medicine (FAAMFM). Designed for active practitioners seeking to lead at the very forefront of patient-centered medicine, FAAMFM delivers the most comprehensive and forward-thinking clinical training available through a highly personalized and flexible format.

Through an advanced, integrative, systems-biology approach to care, FAAMFM has helped clinicians across the globe move past simply treating symptoms but rather deliver optimized clinical outcomes for patients of all ages and backgrounds. The time to do the same for your patients and clinical career is now.

Module I: Advanced Endocrinology: The Hormonal Symphony Module II: Cardiology

"Medicine is always advancing and as physicians, we have to consistently stay informed and knowledgeable. Anti-Aging Medicine is the most important investment in future health."

–Christine Bishara, MD

Module III: Frontiers in Neurology and Brain Health Module IV: Gastroenterology: The Crossroads of Health Module V: TRIADS: A Systems Biology Approach

Module VI: Clinical Strategies to Optimize Metabolic Resiliency,

Module VIII: Longevity Medicine and Bio-HackingOptimizing Lifespan

A4M PLANNING COMMITTEE

A4M FOUNDERS

Mark C. Houston MD, MS, MSc, FAARM, ABAARM

James LaValle RPh, CCN, MT, DHPh

Mark Rosenberg MD, FAARM, ABAARM

Robert Goldman MD, PhD, DO, FAASP Co-Founder

Pamela W. Smith MD, MPH, MS

Andrew Heyman MD, MHSA, ABFM, ABIHM Director of Academic Affairs

Sahar Swidan PharmD, BCPS, ABAAHP, FAARFM Director of Professional Programming

Ronald Klatz MD, DO Co-Founder

PME SESSIONS (NON-CME)

THURSDAY | DECEMBER 8TH

6:15 pm

Treating Adult Hormone Deficiencies

Presented by: Thierry Hertoghe, MD

Location: Lando 4202

6:15 pm

Putting Telomere Biology into Clinical Practice: Case Studies and Pearls

Presented by: Joseph Raffaele, MD

Location: Delfino 4102

Sponsored by: Sponsored by:

FRIDAY | DECEMBER 9TH

6:15 pm

What You Must Know About Allergy Relief: What To Do On Monday Morning

Presented by: Pamela W. Smith, MD, MPH, MS

Location: Titian 2303

6:15 pm

Advances In Longevity Treatment Planning Using Fullscript

Presented by: Jeff Gladd, MD

Location: Veronese 2402

6:15 pm

The 5th Vital Sign - Learn More to Earn More

Presented by: Justin Saliman, MD

Location: Veronese 2404

SATURDAY | DECEMBER 10TH

6:15 pm

Copper for Cardiac: An Overlooked Nutrient Necessary for Cardiovascular and Total Body Health

Presented by: Jack Wolfson, DO, FACC

Location: Titian 2303

6:15 pm

Setting Your Practice Apart from the Competition: A Panel Discussion on the Growing Field of Sexual Health

Presented by: Sarah Brice, RN - Nicole Garcia, MDDeb Matthew, MD - Vernon Williams, MD - Mark White

Location: Veronese 2402

6:15 pm

Hormones and Their Relationship to the Microbiome

Presented by: Pamela W. Smith, MD, MPH, MS

Location: Veronese 2404

Sponsored by:

Sponsored by:

Sponsored by:

Sponsored by:

since 2001

Sponsored by:

Sponsored by:

Putting Telomere Biology into Clinical Practice: Case Studies and Pearls

Free Non-CME Workshop with Joseph M. Raffaele, MD

When: Thursday, Dec 8th at 6:15pm

Location: Delfino 4102 at the A4M Annual World Congress in Las Vegas

Participants will:

• Learn how immune health correlates to telomere length

• Review our 2021 published double-blind, randomized clinical trial that shows TA-65® helps support a healthy immune system

• Understand lab tests that can be used to show progress while on TA-65® • Recognize proven safety, efficacy and bioavailability of TA-65® • Learn best practices for using TA-65® with patients

• Get familiar with the current and future T.A. Sciences products today! • Receive a special offer for attending

Stop by our booth to talk to our experts and for a chance to win one of our latest products.

Visit our booth #5007 at the A4M Annual World Congress in Las Vegas

tasciences.com

PRODUCT SHOWCASE

Sponsored by:

11:30 AM 12:30 PM 1:30 PM

Distinctive Detoxification - A Novel Approach To Support Your Patients

Presented by: Jocelyn Strand, ND

Sponsored by:

12:00 PM

Presented by: Chris D’Adamo, PhD

Sofwave™ Next-Generation Ultrasound Technology for Fine Lines and Wrinkles, and for Eyebrow, Submental and Neck Lifting

Presented by: Edward Zimmerman, MD

Sponsored by:

Martial Arts Presentation

AntiAging Health Secrets of Hollywood Movie Stars and World Champion Martial Artists

An array of famed speakers comprised of World Champion martial arts experts and Hollywood celebrity movie stars will be on the Expo stage to present their personal fitness training secrets and dietary programs on how they stay young, youthful and strong even though many in their 60s and beyond. This has become an annual seminar with these renowned individuals with new ones presenting annually.

Robert M. Goldman, MD, PhD, DO, FAASP

· World Chairman-International Medical Commission

· Co-Founder & Chairman of the Board-A4M

· Founder & Chairman-International Sports Hall of Fame

· Co-Founder & Chairman-World Academy of Anti-Aging Medicine

· President Emeritus-National Academy of Sports Medicine (NASM)

· Chairman-U.S. Sports Academy’s Board of Visitors

Sponsored by:

Presented by: Steven K. Scott

Sponsored by:

Sponsored by: 4:30 PM 5:00 PM

Presented by: Dr. Vohn Watts

We would like to extend a well-deserved congratulations to our 2022 graduates! These Fellows have completed the necessary clinical coursework for the following: Fellowship in Anti-Aging, Metabolic and Functional Medicine; Fellowship in Integrative Cancer Therapy; Fellowship in Stem Cell Therapy; and the Aesthetic AntiAging Fellowship. Best wishes to this year’s graduates!

Mohammed Alkaltham MBChB

Kurt A. Bailey DC, ND, NP-C, FAAMFM, ABAAHP

Rajesh Bhurtyal MBBS, MD

Debra Bluestein NP, FAAMFM, ABAAHP

Chengi Cheong MD, FAAMFM, ABAARM

Jonathan Chew FMNMed, MCMed, BS, FAAMFM, ABAAHP

Kristen Coletti-Giesler MSN, APRN, FNP-C, FAAMFM, ABAAHP

Steven Cooper MD, MBA, FAAMFM, ABAARM

Dinah Doong Weng Lee NMMSc, FICT, FNMed

Aimee Falcone DNP, APRN, FAAMFM, ABAAHP

Annette Fornos MD, IFMCP, FAAMFM, ABAARM

Jennifer Goldstock ANP-BC, FAAMFM, ABAAHP

Aaron Hartman MD, MAR, FAAMFM, ABAARM

Michael A. Herrera MS, PharmD, FAAMFM, ABAAHP

Felipe Herrera Salinas MD, FAAMFM, ABAARM

Jin Ho Kim MD, ABAARM, FSCT

Natasha Mankins PharmD, FAAMFM, ABAAHP

Melissa Markel FNP-C, FAAMFM, ABAAHP

Alice Muntz PhD, MMSc, FAAMFM, ABAAHP

Mussarat-Rahna Rehman MBBCh, BSc, FAAMFM, ABAARM

Bridget Bergens OTRL/L, CPHWC, FAAMFM, ABAAHP

Tara J. Robinson MPAS, PA-C, FAAMFM, ABAAHP

Ileana Sanchez Anderson MD

Tessa Stark ND, FAAMFM, ABAAHP

Jenaro Velez Arteaga MD, FAAMFM, ABAARM

Arta Vojnika MD, FAAMFM, ABAARM

Shivani Wadhwa MBBS, MD

Natsu Watanabe MD, FAAMFM, ABAARM

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A Diverse and Unique Microbiome May Be the Secret to Healthy Aging

By: Microbiome Labs

The community of microbial residents in the human body is called the microbiome. The term “microbiome,” coined by Nobel Prize laureate Joshua Lederberg, describes the body’s population of symbiotic microorganisms—some benign, some bene cial, and some pathogenic. The number of microbes present in the human body is almost the same—or even more— than human cells. These microorganisms occupy many di erent body spaces, with the gut microbiome being the most densely populated and widely studied. The intestine is inhabited by a complex, cooperative, and collaborative microbial community—the gut microbiome—which is essential for normal human development and function. Today, medical and pharmacological science has a solid understanding of the gut microbiome and its role in health and disease. 1

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

High Microbial Diversity’s Impact on Gut Health

Research con rms that a healthy, resilient gut microbiome relies on high microbial diversity. “Microbial diversity” is the number of di erent species in the gut microbiome and how evenly they are spread out. Breaking it down further:

►Diversity is the number of individual bacteria from each bacterial species residing in the gut microbiome.

►Richness is the total number of bacterial species living in the gut microbiome.

High microbial diversity creates a much more capable and resilient community. When many di erent types of microbes with various specialties are available, the likelihood of having just the right one to do just the right job increases.

The more diverse gut bacterial species there are, the more potential for the microbiome to support various functions. Having a diverse and rich microbiome has become a critical biomarker for gut health, as studies have shown that lowered diversity may lead to health concerns. So, how exactly does high microbial diversity support human health? High microbial diversity provides:

• Digestive support: The gut’s bacteria turn undigested prebiotic ber into useful metabolites and compounds, such as shortchain fatty acids (butyrate, propionate, acetate). They also produce many other molecules the body needs by using raw materials from food.

• Immune support: Over 80% of the immune system resides in the gut’s lining, and the microbiome is in constant contact with it. When gut microbial richness and diversity are high, the immune system is stronger, more robust, and more stable.2

• Metabolic support: Metabolically healthy individuals with normal, balanced body weight have greater microbiome diversity than their metabolically unhealthy counterparts.3

• Nervous System support: Animals with lower microbial richness and diversity may display increased anxiety, aggression, and mood uctuation, perhaps associated with their gut microbes’ ability to synthesize “classical” neurotransmitters. Thus, fewer conventional gut microbes could a ect the nervous system and in uence brain function through the bidirectional gut-brain axis.4-6

• Endocrine support. Gut microbes produce numerous compounds of a hormonal nature which are released into the bloodstream and act at distal sites. A vast and diverse array of microbial cells are necessary to support endocrine health.7

• Longevity support. The gut microbiome is a key controller of healthy aging.8

• Comprehensive Health support. Reduced diversity is associated with disease states. Low microbial diversity matters because it’s associated with issues such as:9-13

• Weight management challenges

• Poor cellular response to insulin • Blood sugar imbalances • Elevated blood lipids • Abnormal cell overgrowth • Digestive issues • Colon health problems • Persistent fatigue • Ovarian abnormalities

This is not an exhaustive list, but it does make a critical point—low microbial diversity can lead to poor health. A functional core microbiome is characterized by abundant bacterial species and

is common to various human hosts regardless of age, gender, and geographic location.

The Secret to Healthy Aging May Lie in the Gut

The secret to healthy aging may lie partly in the gut. Analyzing the trillions of microorganisms in the gut may help predict the likelihood of living a long and healthy life. As individuals advance in age, the composition of the gut microbiome tends to change. And research suggests that the greater the change, the better. Studies of fecal samples from people in various age groups suggest agerelated changes in gut microbial composition and diversity. With advancing chronological age, the gut microbiota becomes more diverse and variable.14, 15

The microbes that dominate the guts of healthy people in early adulthood make up an everdecreasing percentage of the microbiome as the decades ensue. At the same time, the proportion of other, less prevalent microbial species rises. But when people are less healthy and more fragile, the opposite seems to occur—the microbiome’s composition remains relatively the same—and they tend to be less long-lived. Thus, a gut microbiome that continually reshapes itself during the aging process is a sign of healthy aging. A microbiome that evolves as individuals age seems to indicate that the microorganisms within it are making the appropriate adjustments for an aging human body.

A microbiome that’s considered healthy for a young adult is not necessarily regarded as bene cial for a senior citizen. The gut microbiome becomes increasingly unique to an individual’s age, starting in mid-to-late adulthood. Healthy individuals aged 80 years and up continue to drift towards a unique microbial composition. This drift isn’t found in less healthy people. In most humans, aging is characterized by a depletion of core bacterial genera, primarily Bacteroides. Retaining high Bacteroides dominance into advanced age, or having low gut microbiome uniqueness, seems to lower an individual’s survivability. Conversely,

a microbiome characterized by lower levels of Bacteroides, or high microbiome uniqueness, may increase an individual’s lifespan.15

People with greater microbiome uniqueness as they age, and subsequently better health and longer lifespans, also had higher levels of health-supportive compounds in their blood, including speci c compounds produced by gut microbes that can help ght chronic disease. They had lower triglycerides and LDL cholesterol levels and higher vitamin D levels. They also had better physical health, greater mobility, and needed fewer medications.15, 16

Gut Microbes Produce Valuable Metabolites

Researchers also found that individuals with microbiome uniqueness upon aging also had higher levels of several valuable metabolites in their blood produced by gut microbes, including indoles, which may reduce in ammation and maintain intestinal barrier integrity. Gut bacteria also produce neurotransmitters, such as serotonin, GABA, and dopamine, and neurotransmitter-like compounds, such as melatonin, which play a crucial role in healthy mood and sleep quality.17, 18

Additionally, a diverse microbiome breaks down non-digestible bers, producing valuable shortchain fatty acids (SCFAs). Clinical trials and published studies have shown that SCFAs exert control over the entire metabolic process. SCFAs regulate the balance between fatty acid synthesis (making of fat), fatty acid oxidation (burning of fat), and lipolysis (breaking down and absorption of fat from diet) in the body. SCFAs activate fat burning while inhibiting the production of stored fat and lipolysis. SCFAs also improve the gut’s health through various local e ects, including:8, 19

• Maintaining intestinal barrier integrity

• Producing and reinforcing the gut’s mucosal lining

A Diverse and Unique Microbiome May Be the Secret to Healthy Aging

• Protecting against in ammation

• Reducing the risk of colorectal cancer

Interestingly, Bacillus spores, found in many sporebased probiotics, have been shown to convert non-digestible bers in the diet into much-desired SCFAs. Studies completed at Ghent University’s ProDigest research facility in Belgium demonstrated that taking Bacillus probiotic strains with ber increased SCFA production by a whopping 40%.20

Age-Dependent Gut Dysbiosis and Unhealthy Aging

The gut microbiome plays a vital and undeniable role in human health—from helping control digestion to bolstering immune function to impacting many other aspects of overall wellbeing. Dysbiosis—imbalances in the gut’s microbial community characterized by too many unfriendly and unhealthy microbes—may contribute to many unwanted health challenges that cause poor aging, such as weight gain, high cholesterol, blood sugar imbalances, and much more.21

Humans have two di erent ages—chronological and biological. Chronological age indicates the number of years a person has been alive. In contrast, biological age refers to how old a person seems, and is based upon many lifestyle factors, such as diet, physical activity, and sleeping habits. Biological age is also referred to as physiological age.

The gut microbiota should ideally become more diverse, increasing in phylogenetic richness as chronological age advances. But when biological age is considered, with adjustment for chronological age, overall gut microbiome richness (total number of bacterial species) decreases, while certain bacteria associated with unhealthy aging may thrive.

The homeostatic relationship between the gut microbiome and the host deteriorates with

increasing biological age, while gut dysbiosis accelerates. Research shows that an aging gut with dysbiosis can negate the microbiome’s bene cial e ects on nutrient signaling pathways and trigger pro-in ammatory innate immunity and other pathologies. A dysbiotic gut can also disturb the communication between the gut microbiome and the host through various biomolecules, epigenetic mechanisms, and CR-independent signaling pathways, impacting host health and longevity.22

In short, as biological age increases, the gut microbiome’s homeostasis with the host decreases, causing dysbiosis. Communication from the dysbiotic gut to the host via various bioactive molecules and signaling pathways can either promote or delay proin ammatory immune reactions and ageassociated degenerative pathologies.

The Microbiome is a Uniquely Accurate Biological Clock

The gut microbiome is an active and dynamic ecological system where the relative abundance of microbial species may uctuate daily, weekly, and monthly depending on factors such as diet, physical activity, medication use, and other environmental in uences. Clearly, individuals who maintain a healthy, diverse microbiome as they age tend to have better health and longevity. Maintaining a healthy gut microbiome can come from many directions—from a healthy diet rich in fermented foods and ber, the ideal amount of physical activity, getting quality sleep, to taking probiotic supplements. Since researchers and healthcare practitioners around the globe have concluded that the microbiome is a uniquely accurate biological clock, able to pinpoint the age of most people within years, perhaps innovative microbiome pioneers will someday even develop age-speci c probiotic supplements, functional foods, and lifestyle recommendations!

Diverse and Unique Microbiome May Be the Secret to Healthy Aging

1. Deo PN, Deshmukh R. Oral microbiome: Unveiling the fundamentals. J Oral Maxillofac Pathol. 2019;23(1): 122-128. doi:10.4103/jomfp.JOMFP_304_18

2. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature 2012;489(7415):220-30. doi: 10.1038/nature11550

3. Zhong X, Harrington JM, Millar SR, Perry IJ, O’Toole PW, Phillips CM. Gut microbiota associations with metabolic health and obesity status in older adults. Nutrients. 2020;12(8):2364. doi:10.3390/nu12082364

4. Hill-Yardin EL, Grabrucker AM, Franks AE, Luna RA, Monif M. Editorial: Interactions of the nervous system with bacteria. Front Neurosci. 2021, Apr 23;15:682744. doi:10.3389/fnins.2021.682744

5. Rastelli M, Cani PD, Knauf C. The gut microbiome in uences host endocrine functions. Endocr Rev. 2019;40(5):1271-1284. doi:10.1210/er.2018-00280

6. Zhao Z, Wang B, Mu L, et al. Long-term exposure to ceftriaxone sodium induces alteration of gut microbiota accompanied by abnormal behaviors in mice. Front Cell Infect Microbiol. 2020 Jun 24;10:258. doi:10.3389/fcimb

7. Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. Gut microbiota: The neglected endocrine organ. Mol Endocrinol 2014;28(8):1221-38. doi:10.1210/me.2014-1108

8. Ragonnaud E, Biragyn A. Gut microbiota as the key controllers of “healthy” aging of elderly people. Immun Ageing. 2021;18(1):2. doi:10.1186/s12979020-00213-w

9. Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541-6. doi:10.1038/nature12506

10. Kostic AD, Gevers D, Siljander H, et al. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe. 2015;17(2):260-73. doi:10.1016/j. chom.2015.01.001

11. Mosca A, Leclerc M, Hugot JP. Gut microbiota diversity and human diseases: Should we reintroduce key predators in our ecosystem? Front Microbiol. 2016 Mar 31;7:455. doi:10.3389/fmicb.2016.00455

12. Giloteaux L, Goodrich JK, Walters WA, et al. Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome. 2016;4(1):30. doi:10.1186/s40168-016-0171-4

13. Lindheim L, Bashir M, Münzker J, et al. Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): A pilot study. PLoS One. 2017;12(1):e0168390. doi:10.1371/journal. pone.0168390

14. Claesson MJ, Cusack S, O’Sullivan O, et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. PNAS. 2011;108(suppl 1): 4586–4591. doi:10.1073/pnas.1000097107

15. Wilmanski T, Diener C, Rappaport N, et al. Gut microbiome pattern re ects healthy ageing and predicts survival in humans. Nat Metab. 2021;3(2):274286. doi: 10.1038/s42255-021-00348-0

16. Castro-Mejía JL, Khakimov B, Krych Ł, et al. Physical tness in communitydwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. Aging Cell. 2020;19(3):e13105. doi: 10.1111/ acel.13105

17. Cryan J, Dinan T. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13(10):701-12. doi:10.1038/nrn3346

18. Lee JG, Woo YS, Park SW, Seog DH, Seo MK, Bahk WM. The neuroprotective e ects of melatonin: Possible role in the pathophysiology of neuropsychiatric disease. Brain Sci. 2019;9(10):285. doi:10.3390/ brainsci9100285

19. Silva YP, Bernardi A, Frozza RL. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front Endocrinol. 2020;11:25. doi:10.3389/fendo.2020.00025

20. Duysburgh C, Van den Abbeele P, Krishnan K, Bayne TF, Marzorati M. A synbiotic concept containing spore-forming Bacillus strains and a prebiotic ber blend consistently enhanced metabolic activity by modulation of the gut microbiome in vitro. Int J Pharm X. 2019;1:100021. doi:10.1016/j.ijpx.2019.100021

21. Hrncir T. Gut microbiota dysbiosis: Triggers, consequences, diagnostic and therapeutic options. Microorganisms. 2022;10(3):578. doi:10.3390/ microorganisms10030578

22. Kim S, Jazwinski SM. The gut microbiota and healthy aging: A mini-review. Gerontology. 2018;64(6):513-520. doi:10.1159/000490615

*These statements have not been evaluated by the Food & Drug Administration (FDA) and are not intended to diagnose, treat, cure, or prevent any disease.

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Microbiome Labs

In 2016, Microbiome Labs unlocked the microbiome’s potential by discovering the world’s first probiotic spores. Today, thousands of medical professionals partner with us to provide clinically validated microbiome supplements. Pioneer health with us at microbiomelabs.com.

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Setting

Practice Apart from the Competition: A Panel Discussion on the Growing Field of Sexual Health

Deb Matthew MD CMO Signature Wellness Belmont, NC

Nicole Garcia MD CMO LA Vitality MD Gardena, CA

Vernon Williams MD CMO The Wellness & Aesthetics Medical Center San Antonio, TX

Sarah Brice RN VP of Sales GAINSWave Dallas, TX

MODERATED BY

Mark White CEO GAINSWave Aventura, FL

JO I N U S F O R

E VE N I N G W O RK SH O P J OIN US : Saturday, December 10th @ 6:15pm Room: Veronese 2404

PRESE N TE D B Y

Pamela W. Smith, M.D., MPH, MS

Dr. Smith is currently the Direc tor of the Center for Personalized Medicine and the founder of The Fellowship in Anti-Aging, Regenerative, and Func tional Medicine. She is also a best-selling author.

Metabolic Bene ts of Fasting Mimicking Diets

By: Min Wie PhD & James Kelley PhD

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Abstract

Humans have evolved to survive a range of hostile conditions, with a lack of food resources being one of the most significant challenges. Because of this, the impact of fasting is both broad and significant throughout our organ systems and at the cellular level. Modern science has revealed that the body’s response to fasting plays an important role in immune function, fat storage and metabolism, insulin and glucose response, microbiome and gut function, and even nervous system function. A fasting nutrition plan mimicking the effects of fasting thus has the potential to deliver wide-ranging benefits, at the same time reduces the burden of a water-only fast. Leveraging nature’s design as a survival mechanism during fasting, it is not surprising that multiple cycles of fasting mimicking diets could introduce a new dietary approach to managing many chronic conditions including obesity, diabetes, and related metabolic diseases.

Introduction

The body’s adaptive response to fasting may very well be one of the primary survival mechanisms in human evolution. Humans (and most animals) have developed the ability to live for prolonged periods of food deprivation, shifting metabolism to utilize energy stores in the body. Recent cuttingedge research has revealed many positive aspects to this shift into a stress-resistant state beyond mere survival. In fact, the modern environment of ubiquitous food supply and near continuous food consumption around the clock may have actually harmed our health, as the intrinsic adaptive response to fasting may impart various beneficial effects for health that we no longer receive. Only through the studies on model organisms including yeast, worms, flies, and mice, we learned the true impact of dietary restriction(DR). Accumulating evidence points to the conserved growthregulatory pathways as key integrators of nutrient and other environmental cues to regulate aging and healthspan. Put simply, the same mechanism designed to help keep us alive during fasting may also play a role in our overall health and longevity.

Implementation of DR is manifold, including restriction of caloric level or specific macroand micro-nutrient intake, intermittent(IF) and periodic fasting(PF), and time-restricted eating(TRE). Chronic calorie restriction(CR) without malnutrition offers one of the most widely used biogerontological paradigms for studying aging and longevity. Restricting calorie intake by 20-40% extends the lifespan in organisms ranging from yeast to non-human primates. In humans, longterm CR leads to changes in body composition that facilitates healthspan, improvements in cardiometabolic risk factors ,and other aging biomarkers.1,2 Although CR is feasible and generally safe, its long duration and restrictive nature hinders its adherence, and the potential side effects (e.g., decrease in bone mineral density, lean body mass, and anemia) limit its adoption.

Fasting, the most intensive form of DR, is a practice that dates back thousands of years – it was primarily involuntary due to food scarcity, but also frequently practiced for health or religious purposes. More recently, it is implemented as prolonged water-only fast or IF in the modern era, both of which may not necessarily involve overall restriction in energy intake. Fasting promotes metabolic and cellular changes that affect oxidative damage and inflammation, optimize energy metabolism, and enhance cellular protection (Longo and Mattson, 2014). Water-only fasting can be difficult to maintain and is potentially unsafe due to side effects including malnourishment, rapid weight loss, reduced blood pressure and hypoglycemia. The regimental nature of IF done over weeks or months also limits its acceptance, though it is becoming increasingly widely practiced. In this article we describe the fasting mimicking diet (FMD), a plant-based caloric-controlled 5-day nutritional plan containing low proteins, low sugars and high unsaturated fats that can mimic the effects that water-only fasting has on IGF-1, IGF binding protein 1 (IGFBP-1), ketone bodies and glucose.3,4 The following section summarizes the current research, and its clinical application.

The development of FMD (preclinical) and underlying mechanisms

The concept of a fasting-mimicking structured meal plan was developed at the Longevity Institute at University of Southern California (USC). Insights from studying aging in model organisms led to the discovery of nutrients sensing signaling pathways as key regulators of aging. These are the IGF-1/insulin signaling pathway, the target of rapamycin (TOR) pathway, the adenosine monophosphate (AMP) activated protein kinase (AMPK) pathway, and the sirtuin pathway. These different processes interact and mediate key aspects of the physiologic response to fasting.

Metabolic Benefits of Fasting Mimicking Diets

Fasting-mimicking diets have been demonstrated both to increase healthy lifespan and serve as therapies in mouse models for a variety of diseases. Cycles of FMD can promote multisystem regeneration, enhance cognitive performance, reduce cancer incidence and aging-associated immunosenescence, a process aided by hematopoietic stem cell-based regeneration.3,5 It can also ameliorate or reverse disease progression in mouse models of multiple sclerosis (MS), type I and II diabetes, inflammable bowl diseases, and cardiometabolic risk and shortened lifespan associated with high fat diet.6,7,8,9

Clinical applications

The version of FMD most widely studied in clinical trials consists of plant-based, pre-packaged meal kits for 5 days, supplying approximately 1100 kcal (4600 kJ) for day 1 (11% protein, 46% fat, and 43% carbohydrate), and approximately 720 kcal (3000 kJ) for day 2–5 (9% protein, 44% fat, and 47% carbohydrate).3,10 FMD is proposed to be used once a month for a period of 3-6 months, with normal foods consumed between cycles of FMD.

FMD on weight management, muscle function and age-related biomarkers

Concern over the fact that energy restriction may leads to frailty dissuades the adoption of chronic CR. Periodic FMD, on the other hand, is implemented once a month for 5 days, with interleaving normal food intake. Evaluated for its effects on metabolic risk factors in 100 generally healthy subjects, 3 cycles of FMD (5-day per month) reduced body weight (approximately 2.2 kg), abdominal and total body fat, and waist circumference; lowered blood pressure; and decreased IGF-1 without negatively impacting the lean body mass or serious adverse effects.10 Moreover, a clinical trial enrolling young healthy male subjects showed that FMD could be safely adopted by strength athletes without detrimentally

impacting the muscle volume and neuromuscular parameters of force production (strength).11

FMD in diabetes

The current standard of diabetes care emphasizes medical nutrition therapy with a focus on weight management through chronic caloric restriction, physical activity, and behavioral changes as part of a lifestyle modification strategy.12 However, in our current environment, adhering to lifelong dietary measures required to mitigate the metabolic disorder of type 2 diabetes is difficult to implement and sustain for many individuals. Periodic fasting and FMD have the potential for disease modification in obesity and diabetes by systemically and simultaneously targeting multiple organs related to diabetes pathophysiology, including fat, muscle, brain, liver, kidney and potentially beta-cells, providing a holistic, upstream, and systemic intervention (Figure 1).

Cycles of FMD reduces body weight and abdominal adiposity. These anthropomorphic changes as well as risk factors relevant to diabetes (blood pressure, fasting glucose, IGF-1, triglycerides, total and lowdensity lipoprotein cholesterol, and C-reactive protein), were more pronounced in subjects at risk of metabolic syndrome and diabetes.10

Diabetes remission, according to the new consensus by the American Diabetes Association, is defined as a return of HbA1c to less than 6.5% that occurs spontaneously or following an intervention and that persists for at least three months in the absence of usual glucose-lowering drugs.13,14 In two small proof-of-concept human trials, FMD reduced HbA1c by as much as 1.4% with 6 cycles and 0.5% with 3 cycles of FMD intervention, demonstrating FMD’s potential for disease modification in diabetes.15,16

In a randomized, controlled, open label study comparing the effects of FMD and Mediterranean

diet in patients with type 2 diabetes and diabetic nephropathy, 6 cycles of FMD, FMD reduced albumin-to-creatinine ratio (ACR) [−30.3(−35.7,−24.9)mg/g; P≤0.05] in patients with microalbuminuria levels at baseline (n=15 in the M-Diet group and n=18 in the FMD group).15 The trial also demonstrated sustained improvement in HOMA-IR (a marker for insulin resistance) several months after cessation of FMD, and significant weight loss of 10kg in the FMD group. Perhaps most interest data rests with the finding that two thirds of the participants in the FMD group was able to reduce their diabetes medications while achieving these metabolic improvements, further suggesting the FMD potential to aid in diabetes remission or regression.

Metabolic impact of FMD in cancer patients

Obesity and metabolic dysfunction have long been linked to increased prostate cancer mortality and overall mortality rates. In addition, the treatment of prostate cancer(PC) with hormonal therapy often leads to metabolic syndrome.

A recently-published study represents the first report on the use of Fasting Mimicking Program

cycles in patients with PC and supports a rationale for further evaluation after two major features of metabolic syndrome were reduced in the study cohort PC patients after completion of the program.16 The study reported crucial metabolic risk factors with an average of 3.79kg (8.36lbs) of weight loss, 4.57cm (1.80in) of waist circumference, and a decrease in systolic and diastolic blood pressure by 9.52mmHg and 4.48mmHg respectively. The high overall compliance of 83% indicated that the intervention was both tolerable and sustainable over the study period. Sub-analysis further suggested that this FMD had more robust effects in patients at higher risk of metabolic syndrome than those with normal risk, pointing to future research areas and potential applications.

FMD protocols

The proper application of FMD in the clinical setting depends on the desired goal, but can be generalized into 3 categories. The di erent protocols are based on the clinical research highlighted above, and their potential bene ts are listed below in Figure 2. The protocols consist of 5-day FMD done once per month, with the duration varying based on goals: 3 months for Healthy Aging & Wellness (either consecutive or quarterly), 4 consecutive months for Metabolic Health & Weight Loss, or 6 consecutive months as part of the Diabetes Remission & Regression Program.17 The protocols are separated into groups based on whether physician oversight is required based on medication management requirements (“consumer” vs “healthcare”).

As with any personalized nutrition program, patients should be evaluated for potential impact

of medications and conditions, and there are those who should avoid fasting or FMD (including women who are pregnant or breastfeeding, individuals who are under 18 or who have active infection, organ failure, or are currently or recently ill.

Conclusion

Author Bios:

James Kelley, MD, MBA

JKelley@L-Nutra.com (614) 634-8943

Dr. Kelley has a background in early-stage medical & biotechnology, in addition to working with and educating physicians, nurses and other healthcare professionals. He is Medical Director & Medical Science Liaison for L-Nutra.

of the multi-system metabolic impact fasting has on the body, harnessing its’ effects seems key to both a longevity lifestyle as well as aiding the treatment of age-related disease. The fasting-mimicking technology opens up the potential of consuming food with precisely controlled energy levels and macronutrient composition to achieve many of the benefits of a water-only fast while preserving physiologic (i.e., ketogenesis or glucose homeostasis) or molecular mechanisms associated with fasting.

Min Wei, PhD

MWei@L-Nutra.com

Dr. Wei is an experienced researcher with a current focus in cellular mechanisms of lifespan regulation, age-dependent genomic instability, and development and clinical application of nutrition interventions. He is Chief Science Officer of L-Nutra.

A 5-Day Nutrition Program Designed to Support & Manage Your Health

The body transitions into a fasting state and fat-burning mode so it can begin cellular clean-up.

Cellular clean-up (autophagy) begins. Fat-burning and ketone production/utilization continues and increases.

Sustained cellular rejuvenation. Sustained fat-burning and ketone burning.

Fat-burning ramps up, contributing to the initiation of ketogenesis (ketone production). By the end of this day (48 hours), ketosis may occur.

Cellular cleaning and rejuvenation continue. Fat-burning and ketosis continue.

Stimulate the Power of the Vagus Nerve

What is the Vagus Nerve?

The vagus nerve is the longest cranial nerve in the body, primarily serving as a sensory nerve, bringing information from the visceral organs to the brain. It has several branching nerves that go to the heart, lungs, stomach, and other organs. In addition to communicating between the brain and the body, it modulates various systems and functions.

What is nVNS?

Non-invasive vagus nerve stimulation (nVNS) is an established therapy that sends gentle, patented electrical stimulation through the skin to stimulate the vagus nerve without surgery. nVNS offers a multi-modal mechanism of action, and the overlap and interplay of these mechanisms help to restore, reset, and replenish the parasympathetic balance.

Effects on autonomic nervous system functions & neuroinflammation

Inhibition of cordical spreading depression

Neurotransmitter regulation and nociceptive modulation

gammaCore (nVNS) is a hand-held, user-administered therapy that is proven to stimulate the vagus nerve1,2. Designed as an easy-to-use device with no downtime, it can be used alone or in combination with pharmacologic treatments without the associated risk of drug interactions. FDA-cleared with 6 indications for migraine and cluster headache, gammaCore can be used for acute and preventive use with short, 4-minute treatment times.

Indication & Important Safety Information

gammaCore™ is intended to provide non-invasive vagus nerve stimulation (nVNS) on the side of the neck for preventive treatment of migraine and the acute treatment of pain associated with migraine in patients 12 and older. gammaCore is also indicated for adjunctive use for preventive treatment of cluster headache, acute treatment of episodic cluster headache, and treatment of hemicrania continua and paroxysmal hemicrania in adult patients.

gammaCore should not be used by people with an active implantable medical device or have a metallic device implanted at or near the neck. Please refer to gammaCore.com or the Instructions for Use for complete safety information, including indications, contraindications, warnings, cautions, and instructions.

References: 1. Nonis, R., D’Ostilio, K., Schoenen, J., & Magis, D. (2017, June 26). Evidence of activation of vagal afferents by non-invasive vagus nerve stimulation: An electrophysiological study in healthy volunteers. Cephalalgia, 37(13), 1285–1293. https://doi.org/10.1177/0333102417717470

2. Frangos, E., & Komisaruk, B. R. (2017, January). Access to Vagal Projections via Cutaneous Electrical Stimulation of the Neck: fMRI Evidence in Healthy Humans. Brain Stimulation, 10(1), 19–27. https://doi.org/10.1016/j.brs.2016.10.008 3. Data on File.

Hyperbaric Oxygenation & Aging:

Repair the EpigenomeLengthen Telomeres Reduce Senescence Mobilize Stem Cells

Abstract:

By: Jason Sonners DC, DCBCN, Ph.D(c)

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Hyperbaric oxygen therapy (HBOT) has been proven to be a noninvasive, safe and e ective therapy for reducing in ammation, improving patient healing times and increasing tissue regeneration. Chronic in ammatory and neurodegenerative diseases are all on the rise year after year in the United States. They cost our medical system billions of dollars annually and destroy the quality of life for both the a ected patient as well as their loved ones who care for them. Common denominators for many of these illnesses include chronic in ammation, metabolic and mitochondrial dysfunction and immune dysregulation. A literature review of current hyperbaric research shows us that there is a pattern of mechanisms of action at play when HBOT is utilized for almost all the FDA approved indications. The same mechanisms of action are responsible for the positive results seen for wound care as they are for crush injuries, thermal burns, resistant infections and neuropathy. Hyperbaric helps to reduce in ammation, increase cellular ATP formation, release stem cells, stimulate collagen production, increase broblast activity, ght infections, stimulate

neurogenesis and angiogenesis as well as release growth factors needed for tissue repair and regeneration. There is mounting evidence which suggests that the mechanisms of action for these more standard “on label” acute cases would be identical to the mechanisms of action required by other chronic illnesses to also improve their cases, outcomes and recovery times. Hyperbaric can be delivered a number of ways, from mild pressure (1.3 atmospheres) to high pressure (2.0 atmospheres and above) and from 21% oxygen through 100% oxygen. In addition to standard hyperbaric protocols, current hyperbaric research also shows that using air-breaks can create intermittent and relative hyperoxic-hypoxic waves of oxygen pressures which is shown to be a strong stimulator of many cell signaling and epigenetic signaling cascades. These cellular signaling cascades can be used for the promotion of and adaptation to improved cellular healing, increased DNA and epigenetic repair and tissues regenerative responses. The research on these concepts are currently in its infancy but recent studies have shown us that hyperbaric oxygen therapy, through hypoxia inducible factor 1a (HIF-1a), Reactive oxygen species (ROS) signaling and Sirtuin stimulation can help promote hormonal balance, nervous system balance, improve mitochondrial performance, reduce in ammation and stimulate cell and tissue regeneration, as well as lengthen patient telomeres. HBOT’s capacity to have such dramatic e ects of healing and recovery make it a perfect modality to be considered for a wellrounded anti-aging and regenerative medicine approach to improve health and quality of life.

Background Content

There are currently 14 FDA approved conditions for Hyperbaric usage in the United States. These include arteriole occlusions in speci c locations, certain anaerobic infections like gangrene,

necrotizing fasciitis and chronic osteomyelitis, carbon monoxide poising, severe radiation and thermal burns, radiation induced necrosis, crush injuries and severe blood loss anemias. These indications are all potentially either life or limb threatening conditions and yet, in many cases, Hyperbaric Oxygen Therapy is often a successful treatment for these people where nothing else could help them. [4,5]

Over the last 10-15 years, interest has grown in the eld of hyperbarics to increase the potential uses of this therapy for more long lasting, chronic and non-life-threatening conditions. While less acute and not life threatening, many of these conditions are still destroying quality of life for those a ected by them. Not only do they alter the lives of those a ected dramatically but they also cost our patients and ultimately our medical system billions of dollars every year. The potential for hyperbaric to help make an impact for these patients is very high and when considering many of the alternatives, hyperbaric therapy is a safe, relatively a ordable and e ective treatment strategy for an overwhelming majority of chronic illness.

The pathology of chronic illness parallels the pathophysiology of aging. In many ways chronic illness creates a pathway towards accelerated cellular aging. Marked by chronic in ammation, mitochondrial dysfunction, cellular senescence, genetic damage and changes to epigenetic and genetic expression, aging is the number one risk factor for developing chronic illness [1,2,3]

Improved ATP production and mitochondrial e ciency, improved DNA replication and protein translation, increases in stem cells, increased telomere length and improved cellular signaling capacity are associated with improved cellular physiology and repair. Hyperbaric therapy has been implicated in assisting with all of these processes in a variety of recent studies. [4,9,12]

Hyperbaric Oxygenation & Aging:

Repair the Epigenome - Lengthen Telomeres - Reduce Senescence - Mobilize Stem Cells

Hyperbaric Oxygen Therapy (HBOT) involves exposing a person to an increase in atmospheric pressure and percentage of oxygen leading to an increase in pressure of oxygen (PO2) greater than what they are typically being exposed to in their environment. This change in oxygen pressure is sensed throughout the entire body primarily through hypoxic inducible factors leading to stimulation of sirtuins and ROS. The overall e ects and bene ts of hyperbaric oxygen are based on 3 variables: pressure, percentage of oxygen and time. [5,8,12]

Hyperbaric Therapy Introduction

There are two phases of the hyperbaric treatment. The time the patient spends inside the chamber, exposed to the pressure, and dissolving the increased oxygen molecules into their circulation (the loading phase) and the period of time when the patient exits the chamber and the oxygen then dissipates out of circulation (the unloading phase). Two primary gas laws govern the hyperbaric experience, Boyle’s law and Henry’s law. Boyle’s law states that there is an inverse relationship between pressure and volume, as you exert pressure on a gas the volume decreases. Henry’s law states that when you exert pressure on a gas while holding it over a liquid you can increase the quantity of that gas dissolved inside the adjacent liquid. Using Boyle’s law we can pressurize a gas (oxygen) inside the chamber in order to t a very large quantity of oxygen inside a relatively small space. As a result of Henry’s law, while the patient breathes this pressurized oxygen we can increase oxygen di usion from the alveoli into circulation signi cantly increasing the amount of oxygen dissolved in the patient’s circulation. This exceeds the typical amount of oxygen normally held inside the plasma. Under normal atmospheric conditions blood plasma typically carries very little free oating O2 (3 ml O2/ liter of blood). With increased pressure of oxygen through HBOT, blood plasma becomes a reservoir capable of holding many times the normal amount of oxygen (up to

60ml O2/liter of blood) making the blood plasma hyperoxic. When the session is over and the patient exits the pressurized environment, that excess oxygen begins to dissipate out of circulation and is ultimately consumed by the surrounding cells. The person at that moment in time is becoming relatively hypoxic (oxygen is rapidly leaving the circulatory system) and this process seems to stimulate the hypoxic pathways creating many cellular adaptations including angiogenesis, stem cell release and HIF-1a stimulation without the typical consequences of hypoxia including loss of mitogenesis and decreased sirtuin activation. This process is referred to as the hyperoxichypoxic paradox. It allows us to gain the bene ts of hyperoxygenation and the bene ts of hypoxia without needing to expose a person to the consequences of long-term hypoxia. [12]

Anti-Aging Rationale:

Age-related diseases and degenerative illness are a growing concern world-wide. HBOT has been shown to help combat degenerative conditions by contributing to the regeneration of tissue and blood vessels through hyperoxygenation, the release of numerous growth factors and stem cell mobilization. Additionally, HBOT promotes collagen activation to help battle the signs of aging including reducing skin damage and maintaining elasticity. Clinical studies have demonstrated the bene ts of HBOT for age-related degenerative conditions by providing cellular aid to all organs in the body to promote health and beauty. Additional studies have focused on the e ects of preconditioning with HBOT and its protective properties against ultraviolet spectrum radiation (UVA). Pre-treatment with HBOT substantially reduced UVA induced cell death and proliferation. In addition, preconditioning with hyperbarics prevented skin creasing and maintained skin elasticity through collagen synthesis.

Many people have struggled to identify a single cause of aging. The consensus is that while

Hyperbaric Oxygenation & Aging: Repair the Epigenome - Lengthen Telomeres - Reduce Senescence - Mobilize Stem Cells

there is no single attributable cause for aging, It is agreed that there are multiple hallmarks of aging which all contribute to the process. These hallmarks include: genetic instability caused by DNA damage, attrition of the protective chromosomal end caps (telomeres), alterations to the epigenome that controls which genes are turned on and o , loss of healthy protein maintenance, dysregulation of nutrient sensing caused by metabolic changes, mitochondrial dysfunction, accumulation of cellular senescence, exhaustion of stem cells, altered intracellular communication and production of in ammatory molecules. Researchers cautiously agree, addressing these hallmarks of aging can slow down aging. Slowing down aging forestalls disease leading to both increased longevity and quality of life.

Etiology of Aging: Aging is associated with in ammation, cell degeneration and cell senescence. Cellular ATP levels contribute to the ability for cells to keep replicating. Telomere length is a possible indication of cellular age and oxidation. HBOT aids in recovery of all muscles, including the heart.

HBOT Mechanism of Action: Stem cell release, increased growth factor release, increased collagen formation, increased broblast activity, increased reverse transcriptase activity, mitogenesis, neurogenesis and improved immune system response.

Patient Selection Criteria: HBOT should be considered for individuals of the aging population looking to possibly regain and or maintain quality of life throughout the aging process. Patients with early stages of immune system compromise, signs of increasing in ammation, slowed metabolism or low energy, or family history of cardiac disease, cancer, neurodegenerative or autoimmune disease should all consider HBOT.

Clinical Management and Utilization Review:

There may be as many as 60 treatments of 100%

oxygen at 2.0 ATA for 90 minutes with 5-minute air breaks every 20 minutes. Additional treatment protocols that have seen limited success include enriched oxygen at pressures of 1.3-2.0 ATA for 60-90 minutes, 3-5 hours/week for 8-12 weeks.

Conclusion:

Humans have long been fascinated by the aging process and compelled to nd the fountain of youth. While there are still many questions surrounding the aging process and chronic illness, we have made enormous strides in our ability to address many of the hallmarks of aging. Hyperbaric therapy has been proven to help manage these hallmarks by reducing in ammation, improving mitochondrial and metabolic function, repairing genetic and epigenetic damage, reducing cellular senescence and mobilizing stem cells. Through more recent research and clinical investigation hyperbaric therapy is proving to be a foundational tool in the quest for improved quality of life. HBOT’s ability to stimulate healing and regeneration, reduce in ammation and promote cellular longevity make it a viable therapy in the regenerative medicine clinic.

Resources:

Hyperbaric oxygen therapy has a wide range of equipment options and patient protocols. The type of chamber you choose to use, the type and amount of additional oxygen you supply the patient, the frequency and duration of the session protocol all depend on the patient, their health issues and/or goals and they type of clinic you want to run. Our goal with HBOT, like any other therapy we deliver should be to match the intensity of our therapy with the severity/urgency of the patients’ needs. Proper training and certi cation in hyperbaric oxygen should be considered if choosing to implement HBOT in your clinic.

Hyperbaric Oxygenation & Aging:

Repair the Epigenome - Lengthen Telomeres - Reduce Senescence - Mobilize Stem Cells

The International Hyperbaric Association (IHA) provides annual conferences, educational materials and other support for their member clinics. Ihausa.org

The International Board of Undersea Medicine (IBUM) provides a wide variety of training and

certi cations for hyperbaric clinics including the necessary safety director training and the newly adopted Functional Medicine Hyperbaric Clinician certi cation. Ibum.org

References:

1. Boss GR, Seegmiller JE. Age-related physiological changes and their clinical significance. West J Med. 1981;135(6):434-440.

2. Son’kin, Valentin & Tambovtseva, Ritta. (2012). Energy Metabolism in Children and Adolescents. 10.5772/31457.

3. Hachmo Y, Hadanny A, Abu Hamed R, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY). 2020 Nov 18;12(22):22445-22456.

4. Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest. 2013;123(3):951-957. doi:10.1172/JCI64125

5. Ishii Y, et al. Effects of hyperbaric oxygen on procollagen messenger RNA levels and collagen synthesis in the healing of rat tendon laceration. Tissue Eng. 1999;5(3):279-86.

6. Oh S, et al. Comparison of the effects of 40% oxygen and two atmospheric absolute air pressure conditions on stress-induced premature senescence of normal human diploid fibroblasts. Cell Stress and Chaperones. 2008;13(4):447-458.

7. Yin W, et al. Down regulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model. Brain Res. 2002;926(1-2):165-71.

8. Li Y, et al. Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia-hypotension rat model. Exp Neurol. 2005;191(1):198210.

9. Gu GJ, Li YP, Peng ZY, et al. Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats. J

10. A Thomson AJ, Drummond GB, Waring WS, Webb DJ, Maxwell SR. Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function. J Appl Physiol. 2006;101:809-816.ppl Physiol. 2008;104(4):1185-91.

11. Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol. 2009 Mar;106(3):988–95

12. Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011 Jan;127:131S–141S.

Hyperbaric Oxygenation & Aging: Repair the Epigenome - Lengthen Telomeres - Reduce Senescence - Mobilize Stem Cells

Distinctive Detoxi cation

The case for including the microbiome in detox strategy

By: Jocelyn Strand, ND Director of Clinical Education, Biocidin Botanicals®

One of the foundational therapeutics in functional medicine is supporting detoxificationfor our patients. When we think of toxicity, endogenous (internally produced) toxins don’t necessarily spring to mind. But the microbiome is a source of metabolites and inflammatory mediators that can either support health and detoxification or contribute to our toxic load and disease. There is a bidirectional relationship between the gut and the liver governed by the microorganisms populating the GI tract, referred to as the gut-liver axis (GLA). It explains why we see deeper cleansing when detoxification protocols are combined with a microbial balancing cleanse. Additionally, biofilms, produced by microorganisms, can be an ongoing source of toxins. If left unaddressed, they can create a continual source of toxic exposure and an obstacle to lasting therapeutic effect.

Environmental Determinants of Chronic Disease

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

There is an ongoing nature vs. nurture (genetics vs. environment) debate. But the field of epigenetics (which describes the effect of environmental factors on the behavior of genes) has proven that the environment carries vastly more weight than the inherited gene under most circumstances. The most influential environmental factors are toxic exposure and total toxic load.

According to the World Health Organization, chronic, non-communicable diseases are rapidly becoming a global epidemic. Neurocognitive, metabolic, autoimmune, and cardiovascular diseases are on the rise. Genetics, lifestyle, and nutrition are not the only underlying causes. Early life, ongoing exposures, and bio-accumulated toxicants also contribute to chronic disease.

ENVIRONMENTAL CONTRIBUTORS

TO CHRONIC DISEASE:

Toxic Elements

Naturally Occurring Substances

Pesticides

Persistent Organic Pollutants

Volatile Organic Compounds

Plastic MECHANISMS OF TOXICITY IN CHRONIC DISEASE:

Oxidative Stress Endocrine Disruption Genotoxicity

Enzyme Inhibition

Dysbiosis

Genetics may predispose individuals to chronic disease, but this cannot account for the rapidly increasing prevalence of chronic illnesses within just a generation or two. There is a

compelling case for pervasive environmental factors as an underlying cause of chronic illness. As Judith Stern of the University of California at Davis states, “Genetics loads the gun, but environment pulls the trigger.” 1 One of the most influential environmental factors is the prevalence of toxicity. The microbiome plays a pivotal role in governing the metabolism of exogenous (externally produced) and endogenous toxins. Let’s take a closer look.

A Healthy Microbiome Bene ts the Host

Beneficial bacteria play a variety of important roles in human health, and dysbiosis (microbiota imbalance) plays a significant role in the pathogenesis of intestinal and extraintestinal illnesses.2 The influence of the microbiome affects multiple areas influencing detoxification. These include:

• Hydration

• Nutrient Synthesis

• Protection against pathogens by a barrier effect Training of the immune system

• Immune reserves for systemic defenses Production of short-chain fatty acids

Short-Chain Fatty Acids

Short-Chain Fatty Acids (SCFAs) are metabolites produced primarily in the colon via enzymatic conversion or fermentation by gut bacteria of indigestible dietary residue. They are key mediators for communication between the host and gut microbes. SCFAs produced by microbes can influence host immunity and metabolism, including promoting T regulatory cell function and reducing risk of inflammatory disease. They also affect gut integrity by decreasing

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270432/

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962619/pdf/394_2018_Article_1703.pdf

the luminal pH, enhancing absorption of some nutrients, exerting beneficial effects against intestinal inflammation, and protecting intestinal epithelial integrity. Finally, SCFAs have a direct impact on gut microbiota composition.3 A healthy microbiome is requisite for the robust production of SCFAs.

Lipopolysaccharides

Lipopolysaccharides (LPS) are found on the outer shell of gram-negative bacteria and are a potent endotoxin contributing to various diseases. LPS is one of many pathogen-associated molecular patterns (PAMPs) and initiates a potent cytokine response (from macrophages and Kupffer cells in the liver), resulting in inflammation through binding of toll-like receptors (TLRs) and direct binding. Even small amounts of LPS due to bacterial infection are sufficient to elicit an inflammatory response.4

Inflammation resulting from LPS in the lumen of the gastrointestinal (GI) tract creates damage to the mucosa and the tight junctions of the gut, leading to increased intestinal permeability, allowing translocation of bacterial metabolites into the adjacent lymphatics and blood flow where it travels via the portal vein and must be cleared by the cells in the liver.5

LPS and the Liver

Removal of intestinal products by the liver is vital in protecting systemic tissues and organs from inflammatory damage. Those products include bacterial endotoxins (LPS), bacterial exotoxins (cytolysin), fungal exotoxins (candidalysin) and other PAMPS from microorganisms - many of which promote hepatocellular injury. Studies show that LPS is cleared within minutes

3. Frontiers | Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines | Pharmacology (frontiersin.org)

4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829348/pdf/fimmu-11594150.pdf

5. https://www.sciencedirect.com/science/article/pii/S0753332221006727

following injection and primarily localized in the liver. The resulting inflammatory cascade causes collateral damage to hepatocytes, and their ability to participate in detoxification.6

The effect of LPS is so significant that it can be considered a cofactor for liver injury. Murine research shows that LPS augments injury by hepatotoxins. In mice with a sterile gut (no LPS), damage due to exposure of hepatotoxins was mitigated. Similarly, in alcoholic liver disease, LPS is also a cofactor. Rats fed ethanol only developed fatty liver. However, when LPS was introduced, it resulted in hepatic necrosis.7

Gut-Liver Axis (GLA)

The Gut-Liver Axis describes a bidirectional pathway in which the gastrointestinal system, microbiome, and the liver influence and depend upon one another. Disruption of the GLA results in loss of homeostasis, compensation, and eventual disease through elevated toxins and resulting inflammation.8

The liver plays a pivotal role in regulating the microbiome by releasing primary bile acids (BA) into the small intestine. Bile acids are antimicrobial and prevent the overgrowth of microorganisms and resultant proinflammatory bacterial metabolites. Reduction in the formation and release of BA is associated with overgrowth of microorganisms in the small intestine. Alterations of bile acid homeostasis leading to excessive intrahepatic accumulation of potentially toxic BAs and their metabolites are thought to play a pivotal role in mediating the hepatic injury of cholestatic diseases.

The vast majority (95%) of primary bile acids are reabsorbed via enterohepatic recirculation.

6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868813/

7. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation | American Journal of Physiology-Gastrointestinal and Liver Physiology

8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004151/

Microbiota modify the remaining 5% into secondary BA.9 Secondary BAs are highly toxic, and excess levels contribute to inflammation, cholestasis, gallstone formation, and carcinogenesis. In the presence of a healthy microbiome (which also acts upon xenobiotics and other endogenous toxins), the effects of secondary bile acids are mitigated by the production of SCFAs exerting their anti-inflammatory effect.10

Small Intestinal Bacterial Overgrowth and Liver Disease

The destruction of liver tissue resulting from dysbiosis is illustrated by the connection between small intestinal bacterial overgrowth (SIBO) and liver disease. Chronic liver disease (CLD) patients have SIBO significantly more often when compared with controls. The association of SIBO and CLD is not confined to patients with advanced disease, suggesting that SIBO is not a consequence of advanced liver disease but may play a role in the progression of CLD.11

Gram-negative bacteria and the resulting elevation in LPS frequently accompanied by SIBO contributes to intestinal permeability, damaging the protective barrier, and increasing risk of non-alcoholic fatty liver disease.12

Bio lms

Biofilms are involved in the majority of clinical infections. They are communities of microbial cells surrounded by a secreted polymer called the “extracellular polymeric substance.” They are composed of multiple organisms (aerobic and anaerobic bacteria and/or fungal species). More than 80% of all microbial infections have developed biofilms within two weeks from the

8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004151/

9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204491/

10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429521/pdf/ijms-2001214.pdf

11. https://pubmed.ncbi.nlm.nih.gov/29272899/

onset of infection. Biofilm bacteria can resist up to 5000 times the antibiotic concentration that would typically be needed to resolve infections and, once established, are an ongoing source of reinfection. Biofilms in the GI tract often contain bacterial metabolites, as described above. In fact, LPS is part of the structure of biofilms.13

The composition of microbial biofilm depends on the environmental conditions in which the microbes reside. Biofilm is a survival mechanism for microorganisms and provides protection from environmental stress, acid, antimicrobials, UV, desiccation, predation, biocides, solvent, toxic chemicals, and other pollutants.14 Biofilms

and Toxicity

Biofilms exist in the natural world, including on and in the human body, where they retain environmental toxicity and create toxic byproducts themselves. How sticky are they? They are used for the biochemical conversion of pollutants by sorption (heavy metals, hydrocarbons, industrial waste, and wastewater). The molecules produced by biofilm communities contain glycoconjugates such as glycoproteins, glycopeptides, peptidoglycans, glycolipids, lipopolysaccharides, and glycosides – many of which result in inflammation and contribute to toxicity in the body.15 Failure to address biofilms can result in refractory illness, and an ongoing source of toxicity.15

Oral Health, Dysbiosis, and Bio lms

When LPS is produced in the gut, the liver clears it, protecting systemic tissues and organs. However, when gram-negative bacteria such as Porphyromonas gingivalis produce toxic metabolites in the mouth, it results in the direct translocation to adjacent blood flow

12. https://pubmed.ncbi.nlm.nih.gov/27308646/ 13. https://pubmed.ncbi.nlm.nih.gov/28950999/ 14. Microbial glycoconjugates in organic pollutant bioremediation: recent advances and applications (nih.gov) 15. https://pubmed.ncbi.nlm.nih.gov/32858856/

| The case for including the microbiome in detox strategy

and lymphatics. Oral dysbiosis and its resultant upregulation of inflammatory pathways is linked to diabetes, cardiovascular disease, Alzheimer’s dementia, respiratory diseases, and more.16

Many of the microorganisms in the mouth participate in the production of biofilms, which are easily identified by the sensation of “fuzzy teeth.” These biofilms have the same qualities and effects as those elsewhere in the body and, as such, are a source of toxicity and recalcitrant disease.17 Evaluation of the oral microbiome is a powerful tool for reducing circulating endotoxins.

Botanicals and the Microbiome

Herbal medicines have been utilized by humans to treat infection for thousands of years and provide a safe and effective option for addressing biofilms and dysbiosis. A study with nearly 400 people found that herbal remedies were as effective as Rifaximin (the most studied antibiotic related to SIBO) at treating symptoms. That trial

Pilot testing at the University of Binghamton has illustrated remarkable broad-spectrum antimicrobial and antibiofilm activity (in vitro) with a combination containing Bilberry extract, Noni, Milk Thistle, Echinacea (Purpurea & Angustifolia), Goldenseal, Shiitake, White Willow, Garlic, Grapeseed extract, Black Walnut (hull and leaf), Raspberry, Fumitory, Gentian, Tea Tree oil, Galbanum oil, Lavender oil, and Oregano oil. Botanicals are E ective Against Bio lms

Botanicals accomplish control of bio lms through several methods. One method is through the inhibition of quorum sensing. Quorum sensing is cell signaling by bacteria and other organisms using autoinducers to determine gene expression, virulence, resistance, and development of bio lms. Botanicals shown to inhibit quorum sensing, such as Garlic and Oregano, are well known for their antimicrobial ability. This understanding of how they can combat bio lms highlights their clinical and historical signi cance.19

used an array of botanicals and essential oils.18

Using the anti-pathogenic properties of more than one botanical in a combination or formula provides a broader spectrum and deeper activity against pathogens. The resulting formulations, or “biocidal combinations,’’ are powerful allies that may be used to address infection.

16 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443998/ pdf/10.1177_0022034520926126.pdf

17 https://pubmed.ncbi.nlm.nih.gov/32858856/

Another method of bio lm control is by the inhibition of e ux pumps within cells, called “multidrug resistance pumps.” Plants containing tannins, berberine, and certain phenolics have e ects as e ux pump inhibitors, demonstrating marked synergy when combined with conventional antibiotics against a variety of both gram-positive and gram-negative organisms. Goldenseal, Black Walnut, White Willow, Raspberry Leaf, and Garlic are a few that have been studied.20

18 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030608/ 19 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119553/ 20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486105/

Detoxification | The case for including the microbiome in detox strategy

Botanicals and LPS

Another recent pilot study illustrates the e ectiveness of a similar biocidal formula. When administered with a formula containing binding agents (activated charcoal, zeolite clay, silica, apple pectin, humic and fulvic acids, aloe), it reduced immune markers associated with LPS exposure after six weeks of application. The potential therapeutic e ect of reducing LPSassociated in ammation is far-reaching.

Botanicals and LPS

Another recent pilot study illustrates the e ectiveness of a similar biocidal formula. When administered with a formula containing binding agents (activated charcoal, zeolite clay, silica, apple pectin, humic and fulvic acids, aloe), it reduced immune markers associated with LPS exposure after six weeks of application. The potential therapeutic e ect of reducing LPSassociated in ammation is far-reaching.

When applying detoxi cation strategies in clinical practice, it is common to include nutrient therapy to supplement detox pathways in the liver and gut. Adding botanicals to balance the

microbiome in the gastrointestinal tract and oral cavity is a well-tolerated and e ective way to uplevel the experience and deepen the e ects – setting patients up for vitality and health.

Detoxification | The case for including the microbiome in detox strategy

Potential of Clinical Assessment of Cancer Invasion and Metastasis

By: Mitchell J. Ghen DO, PhD Claudia Hanau NMD Carsten Evans PhD Irena Ghen MSN, APRN-C

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

One of the hallmarks of cancer described by Hanahan and Weinberg is “Invasion and Metastasis.”1 Most animal research models have difficulty demonstrating this hallmark for several reasons, but in humans, it is considered the cause of death in 90% of cancer patients. Most conventional treatment efforts in patients with distant metastasis have rather poor prognosis. The cells that cause metastasis are most of the time not identified. Additionally, there is currently no perfect evaluation that will absolutely conclude if there is micro metastasis. This is particularly disturbing as statistics clearly show that about 40% of women between 40 and 50 years of age have microscopic breast tumors.2 Additionally, 50% of men between 50 and 60 years of age have microscopic prostate tumors.3 And 100% of people 70 years and older have microscopic thyroid tumors.2,3 A liquid biopsy (blood test) that could identify circulating tumor cells, or a universal cancer marker such as the ENOX2 protein, would give clinicians a benchmark and target for therapies. Circulating tumor cells (CTCs), as well as ENOX2 proteins, which are in the peripheral blood in cancer patients are highly correlative with invasive behaviors of many cancers.

Detection of these cells is often based on the discovery of EpCAM (epithelial cell adhesion molecule) cells. Enumeration of these cells can support a clinician’s suspicion of potential metastasis long before actual distant metastatic lesions can be detected by various types of structural scans. This test is performed using only a few tubes of blood and it is sent to a laboratory with the proper equipment to identify these cells. However, like any other tests, there are shortcomings that one must become familiar with.

Tests for circulating tumor cells (CTC) are based upon the isolation and characterization of cells within whole blood that express molecular markers that indicate the cell is not commonly circulated in the blood and/or the cell may be malignant. In these types of tests, whole blood is often first separated by a density gradient centrifugation device (or a similar device) to remove the majority of the erythrocytes and leukocytes from the sample. The remaining cells are then usually analyzed by flow cytometry. Cells that are positive for either cell surface antigens which are produced by cell types that are not commonly found in circulation, or cells that are overproducing certain cell markers that are common among stem cells or cancer cells are then counted as CTCs. Importantly, many of the cell markers that are used to identify and quantify CTCs are not cancer specific. 4,5 Therefore, cells or cell debris that are released into circulation due to benign inflammatory diseases, such as Crohn’s Disease, will often be detected as CTCs, and lead to frequent false positives.

Epithelial tumor cells will often undergo EMT (epithelial mesenchymal transition). This allows the tumor to invade blood vessels and cells so that the tumor can easily pass into other organ sites. This transition which causes phenotypic changes can simultaneously cause the loss of the epithelial marker expression. We have seen patients with multiple metastatic foci that had minimal EpCAM cells identified. We call these cells

EpCAM negative.6 A clinician must be aware that some patients can have both EpCAM positive and EpCAM negative cells confusing the picture. The presence of EpCAM positive cells in the peripheral blood is rarely identified, therefore finding them should alert the treating practitioner. Since EpCAM positive cells isolation decrease with EMT, when EpCAM positive cells are identified efforts and therapies should be used to arrest and interfere with the EMT process. It is important to realize that EpCAM positive cells can be present in healthy tissue, specifically during development or regenerative processes. We have also seen downregulation or loss of the p53 tumor suppressor gene being accompanied by an increase in EpCAM expression. It is also in the clinician’s best interest to try to have identification of not only the EpCAM positive cells but also their fragments.7

Circulating tumor DNA (ctDNA) is now being extensively studied as it is a noninvasive “realtime” biomarker that can provide diagnostic and prognostic information before, during treatment and at progression. These include DNA mutations, epigenetic alterations and other forms of tumor-specific abnormalities such as microsatellite instability (MSI) and loss of heterozygosity (LOH). While there is significant potential for this approach, ctDNA tests have significant issues. To date, there is no strict standard considering the exact biomarker to detect because the development and progression of cancer is extremely complicated. Also, results of the studies evaluating ctDNA are not consistent due to the different detection methods and processing. The major challenge is still assay sensitivity and specificity for analysis of ctDNA. To date, these tests detect 20% to 50% of cancers present in patients tested.5

Because of tumor heterogenicity, even robust gene signature cancer biomarkers do not always provide a clear clinical treatment

guidance. “Tumor genome sequencing provides a powerful approach for categorizing cancer driver mutating genes; however, it cannot distinguish between those genes that are drivers of tumor progression, metastasis, or both.”8

EV Tests are emerging technology. Extracellular vesicles may be exosomes, microvesicles, apoptotic bodies, retroviral particles and other entities, ranging in size from 30 nm to 4000 nm. Some groups use differential centrifugation or density gradients to remove larger cellular debris and isolate EVs. Other methods include chemical precipitation, the use of serial filters, EV binding resins, immuno-isolation with magnetic beads, and microfluidic separations. It is important to note that the biologic properties and contents of the EVs are greatly influenced by the method of isolation. Moreover, as yet surface markers that uniquely distinguish one EV sub-population from another have not yet been established. Since non-neoplastic cells secrete EVs and these cells outnumber neoplastic cells by several orders of magnitude in a patient, tumor-specific EVs remain a rarity in clinical samples. This rarity limits the sensitivity of EVs as a biomarker platform. Moreover, normalization and quantitation of genetic materials isolated from biofluid EV is an unresolved question.4,5 A major dilemma that all practitioners face is that regardless of which modalities are used, there always remains the perplexing question of when to discontinue treatment. Often protocols are designed for a certain period of time and then a follow up with a patient using imaging is used. But what if we had tangible evidence of not only dissolution of the primary tumor but also its clearance from the microcirculation. It would certainly change how we treat, whether to stop or continue and give comfort to the patient regarding the real time status of their disease state. As mentioned above, there exists a universal cancer marker, Ecto-Nicotinamide Dinucleotide Oxidase Disulfide Thiol Exchanger, (ENOX2), which is present on all cancer cells, without exception, and is shed into the sera of

cancer patients. This protein was discovered by the husband-and-wife team Dorothy and D. James Morré during their tenure at Purdue University.

The Morrés were the first to demonstrate that ENOX2 proteins are cancer-specific,9,10 and are essential to uncontrolled growth and to the ability of the cells to invade tissues (metastasize). As discussed above, these same properties define cancer.11 Their work followed the initial introduction in 1973 of the Plasma Membrane Electron Transport (PMET). This idea was put forth by Cathy Frantz a master’s student at Purdue University in West Lafayette Indiana. The Moorés, along with Drs. Frederick Crane, and Hans Low championed the concept that the plasma membranes might contain redox active proteins with crucial functions in growth and disease. The then scientific community vehemently rejected this notion, but they persevered, nonetheless.

And so, it was the discovery of the PMET that actually led the Moorés to discover the ENOX family of proteins. These are a unique family of cell surface proteins involved in cell growth, biological time keeping, cancer, aging, coronary artery disease, neurodegenerative disease, and viral infections and having properties of prions. Note that both cancer and non-cancer cells have this constitutive NOX, or NADH Oxidase protein.

However, the exon 4 minus splice variant, (ENOX2 or tNOX), is associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients and is absent from the surface of noncancer cells and from sera from healthy individuals. This was demonstrated by Morré via transfection of HeLa (human cervical carcinoma) cells with antisense oligonucleotides and measurement of mRNA levels by real-time quantitative PCR and growth and drug response by in vitro cytotoxicity assays were combined to demonstrate encoding of a cancer-specific and growth-related cell surface protein, tNOX, via an exon 4 minus splice variant.12 tNOX was later designated as ENOX2.

All ENOX2 proteins are found in the outer membrane leaflet of the cancer cells and are produced by the cancer cells themselves. They all share a unique 5-amino acid sequence not found in any other proteins.13,14 It has been documented that ENOX2 expression is the result of alternative messenger RNA splicing events that occur during the benign to malignant transition of cancer progression. It has further been demonstrated that these changes persist.15-17 It is a molecular marker and so there are no false positives.14 Because noncancer cells do not make ENOX2,18,19 it follows, then, that the presence of ENOX2 proteins in sera is indicative of the presence of malignant cells.9,14 Different sites of cancer origin generate site-specific ENOX2 transcript variants based on molecular weight and isoelectric point.9,14

The increased growth in response to oxidase stimulation and the greater sensitivity to antitumor drugs in transformed cells led the Morres to

References:

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000.

2. Breast Carcinoma In Situ. (2015, June 15). Retrieved from https://www.cancer. org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancerfacts-and- figures/2015/special-section-breast-carcinoma-in-situ-cancer-facts-andfigures-2015.pdf

3. Haas, G. P., Delongchamps, N., Brawley, O. W., Wang, C. Y., & de la Roza, G. (2008). The worldwide epidemiology of prostate cancer: perspectives from autopsy studies. The Canadian journal of urology, 15(1), 3866-71

4. Morré, D. J. and D. M. Morré. 2003. Synergistic Capsicum-tea mixtures with anticancer activity. J. Pharm. Pharm. 55: 987-994.

5. Morré, D. M. and D. J. Morré. 2006. Catechin-vanilloid synergies with potential clinical applications in cancer. Rejuvenation Res. 9: 45-55.

6. Mikolajczyk, S. D., Millar, L. S., Tsinberg, P., Coutts, S. M., Zomorrodi, M., Pham, T., Bischoff, F. Z., & Pircher, T. J. (2011). Detection of EpCAM-Negative and CytokeratinNegative Circulating Tumor Cells in Peripheral Blood. Journal of oncology, 2011, 252361. https://doi.org/10.1155/2011/25236

7. Ulrike Schnell, Vincenzo Cirulli, Ben N.G. Giepmans. EpCAM: Structure and function in health and disease. Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1828, Issue 8, 2013, Pages 1989-2001, ISSN 0005-2736, https://doi.org/10.1016/j. bbamem.2013.04.018.

8. Li, J., Lenferink, A., Deng, Y. et al. Identification of high-quality cancer prognostic markers and metastasis network modules. Nat Commun 1, 34 (2010). https://doi. org/10.1038/ncomms1033

9. Hostetler, B., N. Weston, C. Kim, D. M. Morré and D. J. Morré. 2009. Cancer sitespecific isoforms of ENOX2 (tNOX), a cancer-specific cell surface oxidase. Clin. Proteomics 5: 46-51.

10. Morré, D. J. and D. M. Morré. 2003. Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular timekeeping, growth, aging, and neurodegenerative disease. Free Radical Res. 37: 795-808.

11. Su, Y.-C., Y.-H. Lin, Z.-M. Zeng, K.-N. Shao, and P. J. Chueh. Submitted. Chemotherapeutic agents enhanced cell migration and epithelial to mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein. Biochem. Biophys. Acta.

conclude that this was indicative of the importance in the diagnosis and control of cancer. And, indeed, in 2014 a clinical trial confirmed this very premise.20

While it is true that ENOX2 proteins are cell surface-located, they are distinguished from ENOX1 and ENOX3 proteins on the basis of the response of their enzymatic activities to inhibitors, activators, and drugs, amino acid sequence and functional motifs, period length of oscillatory activities (22 min) and entrainment properties.21 Researchers are currently working on developing an ENOX2 Assay. Once marketed, clinicians will no longer face the dilemma that has plagued them up to this point regarding the issue of microtumors, metastasis, evaluating efficacy of the chosen treatment modality as well as when to stop treatment.

12. Tang, X., Morre, D.J., Morre, D.M. Oncology Research, 01 Jan 2007, 16(12):557-567, Antisense experiments demonstrate an exon 4 minus splice variant mRNA as the basis for expression of tNOX, a cancer-specific cell surface protein.

13. Chueh, P.-J., C. Kim, N. Cho, D. M. Morré and D. J. Morré. 2002. Molecular cloning and characterization of a tumor-associated, growth-related, and timekeeping hydroquinone (NADH) oxidase (NOX) of the HeLa cell surface. Biochemistry 41: 37323741.

14. Morré, D. J. and D. M. Morré. 2012. Early detection: An opportunity for cancer prevention through early intervention. In: Cancer Prevention. InTech, Vienna, pp.

15. Tang, X., Z. Tian, P.-J. Chueh, S. Chen, D. M. Morré and D. J. Morré. 2007. Alternative splicing as the basis for specific localization of tNOX, a unique hydroquinone (NADH) oxidase, to the cancer cell surface. Biochemistry 46: 12337-12346.

16. Tang, X., D. J. Morré and D. M. Morré. 2008. Antisense experiments demonstrate an exon 4 minus spice variant mRNA as the basis for expression of tNOX, a cancer-specific cell surface protein. Oncol. Res. 16: 557-567.

17. Tan, X., V. D. Kane, D. M. Morré and D. J. Morré. 2011. hnRNP F directs formation of an exon 4 minus variant of tumor associated NADH oxidase (ENOX2). Mol. Cell. Biochem. 357: 55-63.

18. Morré, D. J., S. Caldwell, A. Mayorga, L.-Y. Wu, and D. M. More. 1997. NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients. Arch. Biochem. Biophys. 342: 224-230.

19. Morré, D. J., A. Bridge, L.-Y. Wu, and D. M. Morré. 2000. Preferential inhibition by (-)-epitgallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture. Biochem. Pharmacol. 60: 937-946.

20. Hanau, C., Morre, D.J., Morré, D.M., Cancer prevention trial of a synergistic mixture of green tea concentrate plus capsicum (CAPSOL-T) in a random population of subjects ages 40-84. Clin Proteomics. 2014 Jan 6: 11(1) :2, doi :10.1186/1559-0275-11-2, PMID 24393573, PMCID; PMC3901999.

21. Morré, D.J., Morré, D.M. ECTO-NOX Proteins: Growth, Cancer and Aging. Springer Science+Business Media New York, 2013.

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1. Al-Shaer A et al. J Nutr. 2022;152(7):1783-1791.

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3. Souza PR et al. Circ Res. 2020;126(1):75-90.

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Human Metabolic Health is In uenced by the Gut Microbiome

By: Christine Stubbe ND

As the field of microbiome research continues to rapidly expand, we are learning about the connections between the gut microbiome and virtually every aspect of human health. One of the more compelling connections relates to the prevalent metabolic diseases of modern Western society. The gut microbiome plays a significant role in metabolic diseases such as cardiovascular disease, type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).

The microbiota interacts with humans mainly through its metabolites or cellular components. In general, a high fiber diet is associated with increased fiber-degrading bacteria and the production of beneficial bacterial metabolites that are protective. The Western diet is higher in fat and protein and can increase the species of protein-degrading bacteria which can produce harmful metabolites.

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Harmful Gut Microbiome Metabolites

Hexa-acylated lipopolysaccharide

Hexa-acylated lipopolysaccharide (Hexa LPS) is a pro-inflammatory component of bacterial cell walls, particularly from certain species in the Proteobacteria phylum. This endotoxin can cross the gut membrane and enter systemic circulation resulting in systemic inflammation. Blood LPS levels are elevated in obesity, type 2 diabetes, and NAFLD.1

Not all LPS is toxic. LPS is a way the immune system monitors the bacteria in the body to distinguish between invading pathogens and harmless commensal bacteria. The hexa-acylated form is more often found in pathogenic bacteria and elicits a signal that triggers inflammation.2

LPS must cross the gut barrier to cause inflammation, therefore gut barrier protection is important to prevent LPS from entering the bloodstream. A randomized controlled trial showed that increased fiber both from fruits and vegetables and from whole grains is associated with reduced blood lipopolysaccharide binding protein (a measure of LPS levels) and inflammatory markers.3 Another study on 146 patients with Metabolic Syndrome showed that an intervention with a high fiber functional food reduced circulating LPS levels as well as improving multiple other metabolic parameters.4 Fiber encourages a healthy microbiota composition and helps the microbiome produce beneficial metabolites such as butyrate and IPA that protect the gut barrier.

Additionally, saturated fat has been shown to increase postprandial blood LPS levels, while omega 3 fatty acids decrease levels. It has been shown that it is the quality of fat, not the quantity that influences postprandial LPS levels.5,6

Trimethylamine

Trimethylamine (TMA) is a bacterially produced metabolite that is converted to trimethylaminen-oxide (TMAO) in the liver. TMAO has been shown to be involved in atherosclerosis, blood sugar control, platelet aggregation, and inflammation. Meta-analyses show that elevated blood TMAO levels are associated with:7-11

• 47% increased risk of all-cause mortality

• 62% increased risk of cardiovascular events

• 89% increased risk of diabetes

• 12% increased risk of hypertension

• Increased CRP

• Increased BMI

Dietary carnitine from red meat can drive microbial TMA production, however, the response is variable.12 Microbes can also use choline to make TMA. Eggs are a rich source of lipid soluble choline, which does not increase plasma TMAO levels.13,14 The lipid soluble form is well absorbed in the small intestine, and therefore does not reach the bacteria in the large intestine. However, in patients with malabsorption due to liver, pancreatic, or gall bladder disease, inflammatory bowel disease, and other gastrointestinal disorders, choline may be more available to the TMA-producing microbes in the large intestine.15

Dietary carnitine from red meat may result in elevated TMAO. Wang, et. al. Eur Heart J. 2019;40(7).

A functional medicine clinician may question whether carnitine or choline supplements could be contributing to increased TMAO production, especially since these are often prescribed for mitochondrial and/or metabolic health. Free choline and carnitine supplements are associated with increased plasma TMAO levels.14,16-19 Lipid soluble choline supplements, such as krill oil or phosphatidylcholine, are not associated with increased TMAO.14,16,19 Some studies show that even with increased TMAO after carnitine supplementation, there are no associated adverse cardiovascular effects, and in some cases, beneficial effects. However, longer term studies are needed as atherosclerosis and cardiovascular diseases develop over the course of years.18,20-22

Increasing cruciferous vegetable consumption may help reduce plasma TMAO levels. The phytochemicals indole-3-carbinol (I3C) and diindolylmethane (DIM) inhibit the conversion of TMA into TMAO in the liver.23

Branched Chain Amino Acids

Branched chain amino acids (BCAAs) leucine, isoleucine, and valine are essential amino acids from dietary protein but can also be microbially produced. BCAAs are important for muscle protein synthesis. Elevated levels of BCAAs are associated with insulin resistance, however, it is not the amount of dietary protein intake or BCAA supplementation that causes this elevation. The mechanisms involving BCAA elevations in insulin resistance are complex and involve reduced BCAA utilization by the liver and adipose. When blood levels of BCAAs exceed the capacity of the muscle to use them, it results in accumulation of toxic compounds leading to insulin resistance. Physical activity increases the muscles capacity to use BCAAs, reducing the risk of insulin resistance.24

Microbially produced BCAAs can be problematic if elevated. Increased microbially produced BCAAs

have been associated with the development of insulin resistance, type 2 diabetes, and obesity.25

A low fiber, Western diet is associated with increased BCAA levels. Increasing fiber may shift certain bacteria in the microbiome towards producing beneficial short chain fatty acids rather than BCAA.25-27

Beneficial Gut Microbiome Metabolites

Short Chain Fatty Acids

Short chain fatty acids (SCFAs) propionate, acetate, and butyrate are beneficial metabolites that carry out many functions for overall health. They are produced by the bacterial fermentation of fiber and can regulate blood glucose, control appetite, promote gut serotonin production, support gut membrane integrity, and reduce inflammation.28,29 A reduction of butyrate-producing bacteria is consistently found in prediabetes and type 2 diabetes.30

Beta glucan, pectin, and resistant starch from whole grains, fruits, vegetables, legumes, nuts, and seeds increase SCFA production.31,32

3-Indolepropionic Acid

3-Indolepropionic acid (IPA) is a bacterially produced antioxidant produced from the breakdown of tryptophan. It protects the nervous system and gut barrier and can also regulate blood glucose levels and suppress inflammation.33,34 A long-term diabetes prevention study showed that higher IPA was associated with reduced likelihood of type 2 diabetes. IPA may mediate its protective effect by preserving pancreatic β-cell function.35

Wholegrain rye and wheat are beneficial for supporting bacterial production of IPA. Additionally, ellagic acid from walnuts and pomegranate may also support IPA production.35,36

Human Metabolic Health is Influenced by the Gut Microbiome

Assessing the Gut Microbiome and Metabolites

These harmful and beneficial gut microbiome metabolites can be assessed using whole genome sequencing (WGS) of the gut microbiome via stool sampling. WGS assesses the microbiome as well as its function. WGS does not measure the metabolites themselves, but rather the genetic potential of the microbiome to make these metabolites. The metabolites TMAO, branched chain amino acids, and lipopolysaccharide antibodies can be measured in blood. Short chain fatty acids can be measured in stool.

Conclusion

A diet and lifestyle system that incorporates a diverse plant-based diet, healthy fats, and exercise can support microbial balance and production of

References:

1. Moreira AP, Texeira TF, Ferreira AB, Peluzio Mdo C, Alfenas Rde C. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nut. 2012;108(5):801-809.

2. Di Lorenzo F, De Castro C, Silipo A, Molinaro A. Lipopolysaccharide structures of Gram-negative populations in the gut microbiota and effects on host interactions. FEMS Microbiol Rev. 2019;43(3):257-272.

3. Kopf JC, Suhr MJ, Clarke J, et al. Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: a randomized controlled trial. Nutr J. 2018;17(1):72.

4. Guevara-Cruz M, Flores-López AG, Aguilar-López M, et al. Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome. JAHA. 2019;8(17):e012401.

5. Lyte JM, Gabler NK, Hollis JH. Postprandial serum endotoxin in healthy humans is modulated by dietary fat in a randomized, controlled, cross-over study. Lipids Health Dis. 2016;15(1):186.

6. Ahola AJ, Lassenius MI, Forsblom C, Harjutsalo V, Lehto M, Groop PH. Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity. Sci Rep. 2017;7(1):6511.

7. Farhangi MA. Gut microbiota-dependent trimethylamine N-oxide and all-cause mortality: Findings from an updated systematic review and meta-analysis. Nutrition. 2020;78:110856.

8. Heianza Y, Ma W, Manson JE, Rexrode KM, Qi L. Gut Microbiota

beneficial microbial metabolites. The Mediterranean diet is a good model for this type of diet. Studies show that a Mediterranean diet beneficially impacts the gut microbiota and associated metabolites, including increased IPA and reduced circulating LPS levels.34,37 Low adherence to a Mediterranean diet correlates with elevated urinary TMAO levels.38 Multiple studies support a Mediterranean diet for cardiovascular disease prevention.39 The key to metabolic health is focusing on gut microbiome health, which begins with a healthy diet.

Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies. JAHA. 2017;6(7).

9. Zhuang R, Ge X, Han L, et al. Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: A systematic review and dose-response meta-analysis. Obes Rev. 2019;20(6):883-894.

10. Ge X, Zheng L, Zhuang R, et al. The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis. Adv Nutr. 2020;11(1):66-76.

11. Dehghan P, Farhangi MA, Nikniaz L, Nikniaz Z, Asghari-Jafarabadi M. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) potentially increases the risk of obesity in adults: An exploratory systematic review and dose-response meta- analysis. Obes Rev. 2020;21(5):e12993.

12. Wang Z, Bergeron N, Levison BS, et al. Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women. Eur Heart J. 2019;40(7):583-594.

13. Zhu C, Sawrey-Kubicek L, Bardagjy AS, et al. Whole egg consumption increases plasma choline and betaine without affecting TMAO levels or gut microbiome in overweight postmenopausal women. Nutr Res. 2020;78:36-41.

14. Wilcox J, Skye SM, Graham B, et al. Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial. Am J Med. 2021;134(9):1160-1169.e1163.

15. Kang JW, Zivkovic AM. Are eggs good again? A precision nutrition perspective on the effects of eggs on cardiovascular risk, taking into account plasma lipid profiles and TMAO. J Nutr Biochem. 2022;100:108906.

16. Mödinger Y, Schön C, Wilhelm M, Hals PA. Plasma Kinetics of Choline and Choline Metabolites After A Single Dose of SuperbaBoost(TM) Krill Oil or Choline Bitartrate in Healthy Volunteers. Nutrients. 2019;11(10).

17. Wu WK, Panyod S, Liu PY, et al. Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery. Microbiome. 2020;8(1):162.

18. Samulak JJ, Sawicka AK, Hartmane D, et al. L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women. Ann Nutr Metab. 2019;74(1):11-17.

19. Cho CE, Aardema NDJ, Bunnell ML, et al. Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men. Nutrients. 2020;12(8).

20. Samulak JJ, Sawicka AK, Samborowska E, Olek RA. Plasma Trimethylamine-N-oxide following Cessation of L-carnitine Supplementation in Healthy Aged Women. Nutrients. 2019;11(6).

21. Sawicka AK, Renzi G, Olek RA. The bright and the dark sides of L-carnitine supplementation: a systematic review. J Int Soc Sports Nutr. 2020;17(1):49.

22. Fukami K, Yamagishi S, Sakai K, et al. Oral L-carnitine supplementation increases trimethylamine-N-oxide but reduces markers of vascular injury in hemodialysis patients. J Cardio Pharmacol. 2015;65(3):289-295.

23. Cashman JR, Xiong Y, Lin J, et al. In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles. Biochem Pharmacol. 1999;58(6):10471055.

24. Shou J, Chen PJ, Xiao WH. The Effects of BCAAs on Insulin Resistance in Athletes. J Nutr Sci Vitaminol (Tokyo). 2019;65(5):383389.

25. Pedersen HK, Gudmundsdottir V, Nielsen HB, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 2016;535(7612):376-381.

26. Tett A, Huang KD, Asnicar F, et al. The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations. Cell Host Microbe. 2019;26(5):666-679.e667.

27. De Filippis F, Pasolli E, Tett A, et al. Distinct Genetic and Functional Traits of Human Intestinal Prevotella copri Strains Are Associated

Author Bio:

with Different Habitual Diets. Cell Host Microbe. 2019;25(3):444453.e443.

28. Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol. 2015;11(10):577-591.

29. Ríos-Covián D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilán CG, Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. 2016;7:185.

30. Arora T, Tremaroli V. Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes. Front Endocrinol. 2021;12:761834.

31. Bang SJ, Kim G, Lim MY, et al. The influence of in vitro pectin fermentation on the human fecal microbiome. AMB Express. 2018;8(1):98.

32. McOrist AL, Miller RB, Bird AR, et al. Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch. J Nutr. 2011;141(5):883-889.

33. Jennis M, Cavanaugh CR, Leo GC, Mabus JR, Lenhard J, Hornby PJ. Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo. Neurogastroenterol Motil. 2018;30(2).

34. Konopelski P, Mogilnicka I. Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease. Int J Mol Sci. 2022;23(3).

35. de Mello VD, Paananen J, Lindström J, et al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Sci Rep. 2017;7:46337.

36. Yang J, Guo Y, Lee R, et al. Pomegranate Metabolites Impact Tryptophan Metabolism in Humans and Mice. Current Dev Nutr. 2020;4(11):nzaa165.

37. Violi F, Cammisotto V, Bartimoccia S, Pignatelli P, Carnevale R, Nocella C. Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease. Nat Rev Cardiol. 2022:1-14.

38. De Filippis F, Pellegrini N, Vannini L, et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut. 2016;65(11):1812-1821.

39. Martínez-González MA, Gea A, Ruiz-Canela M. The Mediterranean Diet and Cardiovascular Health. Circ Res. 2019;124(5):779-798.

Christine Stubbe, ND is a Medical Education specialist, GI product line specialist, and content writer for Genova Diagnostics. She participates in many teaching and speaking events, and has written for peerreviewed journals and other publications.

LEADING THE EVOLUTION OF MICROBIOME ASSESSMENTS

MICROBIOMIX

Genova Diagnostics is excited to announce the addition of metagenomic shotgun/whole genome sequencing with the GI Effects - broadening the clinical landscape of the microbiome beyond all current offerings.

Microbiomix:

• Utilizes metagenomics to assess your patient’s complete gut microbiome as well as its function

• Can detect over 28,000 species of organismsMetagenomics is considered the gold standard method to study the gut microbiota

• Adding it to the GI Effects offers a more complete picture of overall gut health

Nicotinamide Riboside to Support Healthy Aging and Cellular Health

By: Colleen Ambrose ND, MAT

Nicotinamide riboside (NR) is a building block for a critical molecule for cellular health. Nicotinamide adenine dinucleotide (NAD+) is essential for more than 500 biochemical reactions in the human body. Deficiencies in NAD+ have been linked to age-related illnesses.

Supplementation with NR has been shown to support NAD+ status, healthy aging, mitochondrial health, and healthy sirtuin function.1 Sirtuins are chemicals associated with antioxidative status and the support of health during the aging process.2

A double-blind, placebo-controlled clinical trial investigated the efficacy of supplementation with NR and pterostilbene (a sirtuin activator found in blueberries) on hospitalized individuals with acute kidney injury.3 The treatment group (n = 5) consisted of twice-daily titrated doses of NR/pterostilbene: 250/50 mg, 500/100 mg, 750/150 mg, and 1,000/200 mg. NAD+ levels increased by 37% after 2 days. Sirtuin 1 (Sirt1) activation was proposed as a main mechanism of action.3

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

NR may also help support cardiovascular and respiratory health during the aging process. NR has been shown to promote healthy respiratory function, help reduce mitochondrial reactive oxygen species production, and reduce interleukin (IL)-1β levels in peripheral blood mononuclear cells.4 NR has also been shown to influence IL-6 levels; upregulated IL-6 levels are associated with chronic heart failure (HF) and acute myocardial infarction.4

A clinical trial exploring the efficacy of NR supplementation involved 19 patients with stage D HF and a mean left ventricular ejection fraction of 20% and 19 healthy individuals.4 In 5 hospitalized patients, doses of NR escalated from 250 mg twice daily to 1,000 mg twice daily starting on day 3. The study lasted from 5 to 9 days. Study results indicated that supplementation with NR helped support decreased levels in IL-6 and IL-1β and helped support mitochondrial respiration in the hospitalized patients with HF.4 Because of a short study duration and small sample size, more research is necessary before conclusions can be made.

NR may also support cellular respiration and mitochondrial function. A 4-week animal study assessed the efficacy of NR supplementation on Sco2 kiko mice.5 Sco2 is a protein essential for the functioning of cytochrome C oxidase, an enzyme involved in the mitochondrial respiratory chain.6 The administration of NR resulted in increases in NAD+ and the activation of Sirt1.5 The transcription of genes related to oxidative phosphorylation were increased along with increases in mitochondrial respiratory chain activity and oxidative metabolism.5 Motor deficits were also shown to improve.5

NR is believed to have higher neuronal bioavailability due to gene expression in the NR kinase pathway.7 NR kinase 2 has been shown to be induced after axonal injury in sensory neurons.7 An animal study administered NR to murine populations after noise exposure.7

After acoustic trauma, NR was shown to help prevent decreases in cochlear NAD+ levels in a Sirt3-dependent manner.7

Decreases in the activity of Sirt1 and Sirt2 have been linked to diabetic peripheral neuropathy.8 In a murine study, NR administration was reported to help protect against sensory and motor neuropathy in prediabetic mice.8

Although more research is needed before clinical conclusions can be made, NR may support healthy aging and cellular health. It may also support mitochondrial function and a healthy response to inflammation.

References:

1. Airhart SE, Shireman LM, Risler LJ, et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One. 2017;12(12):e0186459. Published 2017 Dec 6. doi:10.1371/ journal.pone.0186459

2. Mehmel M, Jovanović N, Spitz U. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses. Nutrients. 2020;12(6):1616. Published 2020 May 31. doi:10.3390/ nu12061616

3. Simic P, Vela Parada XF, Parikh SM, Dellinger R, Guarente LP, Rhee EP. Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI. BMC Nephrol. 2020;21(1):342. Published 2020 Aug 13. doi:10.1186/s12882-02002006-1

4. Zhou B, Wang DD, Qiu Y, et al. Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure. J Clin Invest. 2020;130(11):6054-6063. doi:10.1172/JCI138538

5. Cerutti R, Pirinen E, Lamperti C, et al. NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease. Cell Metab. 2014;19(6):1042-1049. doi:10.1016/j.cmet.2014.04.001

6. Yang H, Brosel S, Acin-Perez R, et al. Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet. 2010;19(1):170-180. doi:10.1093/hmg/ddp477

7. Brown KD, Maqsood S, Huang JY, et al. Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss. Cell Metab. 2014;20(6):1059-1068. doi:10.1016/j.cmet.2014.11.003

8. Chandrasekaran K, Anjaneyulu M, Choi J, et al. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1α-TFAM pathway. Int Rev Neurobiol. 2019;145:177-209. doi:10.1016/bs.irn.2019.04.002

Author Bio:

Dr. Colleen Ambrose is a Doctor of Naturopathic Medicine; consultant in health, education, and research; writer; and proud alumna of New York University, Relay GSE, and Bastyr University. She received her Doctor of Naturopathic degree from Bastyr University in Seattle, a 4-year accredited program with training in primary care, botanical medicine, osteopathic manipulation, hydrotherapy, and homeopathy.

Dr. Ambrose works to increase access to health care for BIPOC and LGBTQ+ populations, and she believes that all body sizes deserve respect and excellent medical care. She has studied hydrotherapy in Germany and was awarded a grant to study sauna therapy in Finland. She works with inherited behavioral patterns that hold individuals back from living a deeply beautiful life on an emotional, physical, and spiritual level.

Niagen® Meets Designs for Health®

When the leading practitioner brand partners with the most researched form of nicotinamide riboside (NR), the results are groundbreaking for providers and patients. Niagen®

NR is a unique precursor to NAD+ that occurs in the body* Learn more about these two new, exclusive formulas and the science behind NR at designsforhealth.com/niagen Ratings based on results of the 2022 ConsumerLab.com Survey of Supplement Users. More information at www.consumerlab.com/survey

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D o y o u w i s h y o u c o u l d d o m o r e f o r y o u r p a t i e n t s , b u t d o n ' t h a v e t h e t i m e o r r e s o u r c e s ?

T h e F u n c t i o n a l M e d i c i n e P r o j e c t a n d T o t a l H e a l t h R e s e t P r o g r a m a r e t h e s o l u t i o n s y o u ' v e b e e n l o o k i n g f o r . H e l p y o u r p a t i e n t s r e v e r s e c h r o n i c c o n d i t i o n s a n d g i v e t h e m t h e m u c h - n e e d e d k n o w l e d g e a n d k n o w h o w t o g e t t h e i r h e a l t h b a c k . L e a r n M o r e ! V i s i t B o o t h # 3 0 4

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The Inside-Out of Sexual Wellness: Using Nitric Oxide and Other Non-Invasive Recommendations for Improving Sexual Function

All health begins on the inside: Exploring the role of circulatory and whole-body health in sexual support protocols.

To have a meaningful discussion about improving sexual function necessarily involves talking about other deeply connected bodily functions. And, arguably, nothing is more foundational or connected to sexual health — and indeed whole-body health — than circulatory function.

By: Ann Doggett DC, MS

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Because healthy circulation and blood flow is so critical to whole-body health, the reduction of circulation has far-reaching impacts on the body, including systems critical for appropriate sexual function. Some of these include nerve health, blood flow to the brain and sexual organs, and hormone production. These systems all work synergistically, and if one isn’t functioning properly due to reduced circulation, the other systems will suffer.

In other words, multiple systems need to be online for healthy sexual function to happen. For example, in nerve health, poor circulation and the resulting lack of oxygen, nutrients and glucose can adversely affect the nerves’ ability to produce ATP (adenosine triphosphate). ATP is the energy molecule driving physiological processes in the body. It is the source of energy that keeps everything functioning properly, including the sexual organs.

Enter Nitric Oxide: the circulatory system’s superhero

Meanwhile, talking about healthy circulation also necessitates talking about nitric oxide (NO) production. NO was proclaimed “Molecule of the Year” for 1992 by the journal Science, and six years later the Nobel Prize in Physiology or Medicine was awarded to scientists who had discovered NO pathways and shed light on the roles of NO.1 As one example, NO plays a crucial role in circulation and, in many physicians’ opinions, is integral to improving and maintaining circulatory health. In addition, NO has been shown to be an important messenger in many organ systems throughout the body, and particularly in the central nervous system (CNS).2

There are 2 different pathways our body has to produce NO:

1. Nitric Oxide Synthase (NOS) enzyme system that produces NO from L- arginine

2. Nitrate to nitrite to NO reduction pathway

NO is produced in all tissues and the belief is that its production determines physiological actions throughout the body, including the enhancement of sexual response and arousal.3 However, by the age of 40, our NO production through the NOS enzyme system functions around 50%. By the time a person ages to 60 years old, eNOS only functions at 15% of capacity. Nitrates, on the other hand, will bypass the NOS enzyme system as well as help to recouple NOS, thus enabling improved function. Nitrates are able to scavenge free radicals and improve oxidative stress which is rampant in any chronic condition such as diabetes, neuropathy and sexual dysfunction.

Nitric Oxide is essential to adequate blood flow, and adequate blood flow is essential to sexual health. Because NO is so pivotal to healthy circulation and organ systems,

it follows that increasing NO production in the body can help counter and treat the reduced circulation that is behind so many disorders, including sexual dysfunction.

Hormones, NO, and mood: Working together to promote blood flow to parts and systems

While it’s right to focus on the key impact of blood flow to sexual organs (parts) in a conversation about sexual wellness, it’s also important to acknowledge the vital role of hormone production in sexual function. Additionally, blood flow plays a part in developing the hormones that fuel sexual systems and function. And as we’re designing sexual wellness protocols, it’s important to understand how hormones impact NO production — and viseversa, how NO impacts hormone production.

Hormones have a strong effect on the pathways that stimulate NO production. Likewise, the presence of NO plays a role in some hormone regulation. For example, endothelial nitric oxide synthase (eNOS) and its product, nitric oxide (NO), control clitoral blood flow during female sexual arousal.4 Several hormones positively stimulate endothelial Nitric Oxide Synthase (eNOS) in the production of NO. These hormones include estrogen, testosterone, progesterone, DHEA, insulin, growth hormone, and Triiodothyronine (T3).

Meanwhile, NO regulates hormone release in the hypothalamic-pituitary axis. NO triggers the pulsatile release of luteinizing hormone-releasing hormone (LHRH), which mediates luteinizing hormone (LH) release.5 When LH is released, it stimulates the production of steroid hormones from the testis (testosterone) and the ovaries (estradiol).

Aside from hormone production, adequate blood flow also impacts our mood and mental well-being and plays a role in regulating anxiety6 — all of

The Inside-Out of Sexual Wellness: Using Nitric Oxide and Other Non-Invasive Recommendations for Improving Sexual Function

which set the stage for proper sexual function to happen. To that end, NO influences mental health in several ways. Studies have shown that increasing NO production will help an individual feel better, think better, sleep better, and experience less symptoms of anxiety and depression.

Now that we’ve covered some of the “inside” work that needs to be done around improving circulation — which is mainly accomplished by increasing and maintaining proper NO production, typically through supplementation — in the context of other important systems and whole-body health, let’s now turn to the “outside” aspects of a sexual wellness protocol.

Integrating the inside and the outside: In-office sexual health protocols for men and women

Since opening my clinic doors 30+ years ago, my staff and I have evolved our disciplines to serve patients of all ages and conditions. My goal is always to provide safe, effective, and natural answers to health and wellness concerns for the community. Using only the highest-quality products on the market, I have helped patients across the country in uncover the root cause of their health challenges.

Before layering technologies into sexual wellness protocol, I consider questions that assess patients’ lifestyle and the associated impacts on their health, their circulatory health, hormone production, mental health and more in addressing their sexual wellness concerns.

Addressing these central areas with patients their treatment outcomes. Specifically, addressing adequate levels of circulation and NO production in patients can help amplify the success of additional layers of protocol — such as outside technologies — and set a strong foundation for incorporating additional non-invasive recommendations for treating sexual dysfunction.

Technologies we use in sexual wellness protocols

In keeping with market demand for supporting good health both inside and out, our practice expanded over the last several years to include services in the aesthetic space. As some of our services utilize technologies for supporting urinary incontinence, this naturally starts patient conversations about the pelvic floor and overall sexual health. Today, our practice has evolved to provide a multifaceted approach to taking care of patients’ wholebody needs and addressing the systems we’ve discussed so far — from circulation, to mood, to hormone production, to sexual function.

Lifestyle consultation

To deliver on our holistic approach, we provide lifestyle counsel, including addressing sleep hygiene, encouraging regular consumption of whole and non-processed food, and discovering ways to move the body consistently. These set the basis for our patients who are in pursuit of optimizing their potential. For the patient base troubled by low libido, vaginal dryness, erectile dysfunction or lack of orgasm, taking a complete look at energy levels, circulation, muscle strength and blood vessel health is absolutely essential.

State-of-the-art magnet technology + nitric oxide

While using magnets for healing is not a new concept, incorporating medical-grade technology to apply electro-magnetic treatments to specific muscle groups is a state-of-theart technology we use in treating patients. Magnets can be applied to pelvic floor muscles to create contractions in the muscle, resulting in hypertrophy and hyperplasia. As it applies to pelvic floor health, this may result not only in a reduction in urinary incontinence symptoms, but also improved sexual function and satisfaction — especially as it relates to strength of orgasm.

The Inside-Out of Sexual Wellness: Using Nitric Oxide and Other Non-Invasive Recommendations for Improving Sexual Function

In addition, anytime we can also improve blood flow and circulation, we potentially enhance these desired effects. That is why nitric oxide supplements rank high in our current protocols as a complete approach to pelvic floor and sexual health.

Wave therapy + nitric oxide

Another technology instrumental in eliminating blocks to sexual satisfaction in our male clients is shockwave therapy — although we prefer to refer to the treatment as wave therapy when engaging patients in initial conversation. Low intensity sound waves applied to the pelvic area removes micro plaques from the soft tissue and stimulates the growth of new blood vessels. Adding nitric oxide supplements of top quality provides additional support for an optimal outcome.

Examples of successful protocols we use

For our female patients, we prescribe:

6-8 treatments with electromagnets, reinforce once every 6 months.

Two to four capsules of a high-quality nitric oxide support supplement taken daily on an ongoing basis.

1 vaginal rejuvenation treatment combining cryotherapy with radio frequency, annually.

For our male patients, we prescribe:

3-6 wave treatments, annually.

Six food-based b vitamin supplements for cardiac strength taken daily on an ongoing basis.

Two to four capsules of high-quality nitric oxide support supplement taken daily on an ongoing basis.

Conclusion

• Circulatory health is synergistic with sexual health as it affects the whole body and underpins systems and states that must work in unison for proper sexual function to occur. These include blood flow, nerve health, hormone production, mood, mental health, and more.

• Addressing these crucial whole-body concerns with patients — before leveraging outside technologies — can enhance treatment outcomes once technologies are introduced.

• Specifically, addressing adequate levels of circulation and NO production in patients first can amplify the success of additional layers of protocol — such as outside technologies — and establish a strong foundation for incorporating additional, non-invasive recommendations for treating sexual dysfunction.

• Non-invasive recommendations include technologies that offer us the opportunity to narrow in on the specific organs involved in sexual health to amplify positive outcomes — and shorten the time to patients seeing improvement.

• Technology, circulation-supporting supplementation, and lifestyle consultation can work together to provide a comprehensive and effective protocol for improving sexual health.

The Inside-Out of Sexual Wellness: Using Nitric Oxide and Other Non-Invasive Recommendations for Improving Sexual Function

References:

1. Zhou L, Zhu DY. Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications. Nitric Oxide. 2009;20(4):223-230. doi:10.1016/j.niox.2009.03.001

2. Džoljić E. Why is nitric oxide important for our brain? Functional Neurology. Published online 2015. doi:10.11138/fneur/2015.30.3.159

3. Ghasemi A, Zahediasl S. Is Nitric Oxide a Hormone? Iranian Biomedical Journal. 2011;15(3):59-65. https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC3639748/

4. Oliver JL, Kavoussi PK, Smith RP, et al. The Role of Regulatory Proteins and S-nitrosylation of Endothelial Nitric Oxide Synthase in the Human Clitoris: Implications for Female Sexual Function. The Journal of Sexual Medicine. 2014;11(8):1927-1935. doi:10.1111/jsm.12576

5. Całka J. The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons. Folia Histochemica Et Cytobiologica. 2006;44(1):3-12. https:// pubmed.ncbi.nlm.nih.gov/16584085/

6. Gulati K, Rai N, Ray A. Chapter Seven - Nitric Oxide and Anxiety. ScienceDirect. Published January 1, 2017. Accessed October 6, 2022. https://www.sciencedirect.com/science/article/abs/pii/ S0083672916300437

7. Zhou L, Zhu DY. Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide. 2009;20:223–230.

8. Džoljić E, Grbatinić I, Kostić V. Why is nitric oxide important for our brain? Funct Neurol. 2015 Jul-Sep;30(3):159-63. doi: 10.11138/ fneur/2015.30.3.159. PMID: 26910176; PMCID: PMC4610750.

9. Ghasemi A, Zahediasl S. Is nitric oxide a hormone?. Iran Biomed J. 2011;15(3):59-65

10. Oliver JL, Kavoussi PK, Smith RP, Woodson RI, Corbett ST, Costabile RA, Palmer LA, and Lysiak JJ. (2014). The role of regulatory proteins and snitrosylation of endothelial nitric oxide synthase in the human clitoris: Implications for female sexual function. J Sex Med 2014;11:1927–1935.

11. Całka J. The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons. Folia Histochem Cytobiol. 2006;44(1):3-12.

Dr. Ann Doggett, DC, MS 617-328-6300

DrAnn@wholebodysolutions.org

Dr. Ann Doggett, owner and founder of WholeBody Solutions clinic outside of Boston, received her Doctorate of Chiropractic from the New York Chiropractic College and holds a Master’s Degree in Human Nutrition from University of Bridgeport.

The Inside-Out of Sexual Wellness: Using Nitric Oxide and Other Non-Invasive Recommendations for Improving Sexual Function

Copper: An Essential Trace Element for Cardiac Longevity

By: Jack Wolfson DO, FACC Natural Heart Doctor

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

When you think of copper, what comes to mind? Most people would say a shiny penny or pipes in their house. Not many people would mention copper as an essential nutrient for health. But just because copper isn’t as well-known as other minerals like magnesium and iron, doesn’t mean it’s not vital. In fact, copper is a nutrient that plays an integral role in the cardiovascular system. It turns out that copper is great for pipes in your house and the “pipes” in your body such as arteries and veins. So please read on about the supporting evidence that copper is critical for heart health.

Copper and Physiology

A little bit about copper and the role it plays in energy production, cellular water formation, oxidative stress, connective tissue formation, and iron metabolism.

First off, copper is part of the electron transport chain (ETC) in mitochondria, specifically, the cytochrome C oxidase enzyme known as step IV out of V. The ETC turns food and oxygen into H2O, CO2, and ATP. A deficiency in copper is likely to interfere with the production of cellular water and ATP generation by disruption of the proton gradient in the inner mitochondrial membrane.

Second, copper is involved in our antioxidant defense system as the copper- and zinc-containing SOD1 enzyme catalyzes the dismutation of the deleterious superoxide radical (O2−) to molecular oxygen or hydrogen peroxide, which is in turn reduced to water by other enzymes. SOD1 is present systemically but also localized to the inner mitochondrial membrane. This antioxidant function inside the mitochondria is critical for enzyme activity and in the process of mitophagy.

Third, the copper-containing protein ceruloplasmin is responsible for iron mobilization and utilization. The purpose of ceruloplasmin was once thought to be strictly that of copper transport in the body. This area of knowledge has evolved into a deeper understanding that copper-containing ceruloplasmin serves as a catalyst for redox reactions in plasma. It can oxidize iron from ferrous (2+) to ferric iron (3+), and this assists in the binding of iron to transferrin. It is also thought to be involved in controlling membrane lipid oxidation. In the presence of superoxide, ceruloplasmin promotes LDL oxidation and may contribute to atherosclerosis.

Fourth, the copper-dependent LOX enzyme is critical to catalyze lysine-derived crosslinking of collagen and elastin fibrils in the extracellular matrix. Inhibition of collagen and elastin crosslinking reduces the tensile strength and elastic properties of connective tissues, which results in a failure to maintain normal cardiac contraction and the development of concentric cardiac hypertrophy.

Other uses of copper include melanin synthesis, blood coagulation, and neuron peptide maturation.

Given all of the above-mentioned physiological roles of copper, it is not surprising that studies of cell culture, animals, and human genetics have demonstrated that dysregulation of copper

metabolism leads to heart disease, which is the #1 cause of mortality in the US and worldwide.

Defects of copper homeostasis caused by perturbed regulation of copper chaperones or copper transporters, or by copper deficiency, resulted in various types of heart disease, including coronary artery disease, hypertrophic heart disease, and congestive heart failure.

Why Are People Deficient?

Although a trace amount of copper is required daily, copper deficiency is common because the amount of copper in modern diets has decreased during the last several decades. Western-style diets enriched in saturated fat and simple sugars, particularly fructose, inhibit small intestinal copper absorption and, thus, contribute little to the daily dietary requirement for copper. In addition, changes in farming methods have decreased the copper content of soil and, thus, in produce. In fact, the National Health and Nutrition Examination Survey1 revealed that more than 80% of 103,655 people studied in the US received a lower amount of copper than the RDA from their diet. Similarly, dietary copper intake was lower in the National Diet and Nutrition Survey (NDNS) from 2000/01 than in 1986/87 in the UK1.

Copper Deficiency and Coronary Artery Disease

Coronary artery disease (CAD) should be understood as changes to a heart artery leading to plaque formation and obstruction of the vessel. It is the end result of many different factors including a poor diet, an unhealthy lifestyle/ environment, and mental health issues. Copper deficiency related to these factors is therefore linked to the development of CAD through a variety of mechanisms. Copper’s role in the prevention of oxidative stress, mitochondrial function, and collagen crosslinking makes it essential for healthy blood vessels. An

Copper: An Essential Trace Element for Cardiac Longevity

understanding of vascular biology makes it easy to understand how low levels of copper lead to CAD. In addition, abnormal lipid metabolism and oxidized lipids in the face of copper deficiency is another causative factor. Diet-induced copper deficiency increases hepatic glutathione levels and subsequently increases the activity of cardiac hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, which controls the rate-limiting step of cholesterol biosynthesis. Supplementation of hypercholesterolemic patients with 5 mg/ day copper for 45 days decreased total plasma cholesterol and slightly increased high-density lipoprotein (HDL) cholesterol. Interestingly, a 2018 study in the American Journal of Clinical Nutrition found that higher levels of serum copper were protective against acute myocardial infarction2. Finally, statin drugs have been linked to a lower serum copper level, a finding that merits more investigation and could mean more aggressive copper supplementation in statin users source3

Copper Deficiency and Atrial Fibrillation

Atrial fibrillation is a very common heart rhythm disorder affecting tens of millions of people in the U.S. and around the world. It is responsible for significant morbidity and mortality along with a significant financial burden. This financial impact includes the cost of pharmaceuticals, procedures, doctor visits, and lost time at work. Strategies to reduce this burden must be studied.

Copper appears to play a significant role in the maintenance of normal sinus rhythm. The fact that copper supports mitochondrial activities and supports oxidative stress reduction are likely key mechanisms. In addition, atrial fibrillation is often preceded by decreased atrial contractility. Copper deficiency may lead to impaired cardiomyocyte contractile function and calcium homeostasis.

Recently, a study was conducted looking at serum copper levels and plasma oxidase activity

of ceruloplasmin were measured in 33 patients with paroxysmal atrial fibrillation. The authors found lower serum copper levels at hospital admission compared to age-matched controls.

Copper Deficiency and Hypertension

High blood pressure is another common ailment among a large portion of the adult population. Unfortunately, this diagnosis is now occurring among even younger people than ever before. Copper is a very important nutrient for blood vessel health and thus a deficiency has been linked to hypertension. One likely mechanism is by inhibition of endothelial nitric oxide (NO) production, as observed in the rodent model4. Copper has been found to inhibit the activity of an angiotensinconverting enzyme, a key enzyme for blood pressure regulation, and a study found low blood copper levels in the hypertensive group compared to normal controls in animal models. Patients with moderate hypertension were associated with marginal copper deficiency in a study5.

Copper Deficiency and CHF

Nutrients such as zinc, magnesium, and B vitamins are long known for their support of systolic and diastolic cardiac function. Copper has a place alongside these. Kang et al. showed that dietinduced copper deficiency in mice for 5 weeks resulted in systolic and diastolic dysfunction, including a significant 17% decrease in left ventricular peak systolic pressure (LVPSP), a ~50% decrease in the maximum rate of the rise of left ventricular pressure (+dP/dt) and in the maximum rate of the decline of left ventricular pressure (−dP/dt), as well as increases in left ventricular end diastolic pressure (LVEDP) and the duration of relaxation by 115% and 23%, respectively6. After months of copper-restricted feeding, rats show cardiac systolic and diastolic dysfunction, evidenced by a blunted response of +dP/dt, − dP/dt, and LVEDP to isoproterenol7. Feeding a

Copper: An Essential Trace Element for Cardiac Longevity

copper-adequate diet for 4 weeks to diet-induced copper-deficient mice completely restores cardiac diastolic and systolic function and the response to β-adrenergic stimulation suggesting that the cardiac response to β-adrenergic stimulation requires copper8. The molecular mechanisms by which copper deficiency induces heart failure are likely oxidative stress-related, but also by disruption of calcium channels and calcium homeostasis. In addition, copper deficiency reduces NO production by inhibiting SOD activity in endothelial cells and consequently impairs endothelial function. This effect would put extra stress on the heart, thus leading to systolic and diastolic dysfunction.

Conclusion

Copper is a critical component of mitochondrial, cellular, and organ function. Its role in optimal cardiovascular health and longevity is well documented. Diagnosis of copper deficiency and provisions of supplemental copper over and above dietary requirements seem like a prudent strategy for patient success.

References:

1. Liu Y, Miao J. An Emerging Role of Defective Copper Metabolism in Heart Disease. Nutrients. 2022 Feb 7;14(3):700. doi: 10.3390/nu14030700. PMID: 35277059; PMCID: PMC8838622.

2. Hanish P Kodali, Brian T Pavilonis, C Mary Schooling, Effects of copper and zinc on ischemic heart disease and myocardial infarction: a Mendelian randomization study, The American Journal of Clinical Nutrition, Volume 108, Issue 2, August 2018, Pages 237–242, https://doi.org/10.1093/ajcn/ nqy129

3. Majid Ghayour-Mobarhan, David J. Lamb, Andrew Taylor, Nandita Vaidya, Callum Livingstone, Timothy Wang, Gordon A.A. Ferns, Effect of statin therapy on serum trace element status in dyslipidaemic subjects, Journal of Trace Elements in Medicine and Biology, Volume 19, Issue 1, 2005, Pages 61-67, ISSN 0946-672X, https://doi.org/10.1016/j.jtemb.2005.06.003.

4. Falcone JC, Lominadze D, Johnson WT, Schuschke DA. Endothelial cellderived nitric oxide mobilization is attenuated in copper-deficient rats. Appl Physiol Nutr Metab. 2008 Dec;33(6):1073-8. doi: 10.1139/H08-091. PMID: 19088764; PMCID: PMC2652130.

5. Bastola, M.M., Locatis, C., Maisiak, R. et al. Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011–2016). BMC Cardiovasc Disord 20, 45 (2020). https://doi. org/10.1186/s12872-020-01355-x

6. Elsherif L., Ortines R., Saari J.T., Kang Y.J. Congestive Heart Failure in CopperDeficient Mice. Exp. Biol. Med. 2003;80:745–757. doi: 10.1177/153537020322807-06.

7. Li Y., Wang L., Schuschke D.A., Zhou Z., Saari J.T., Kang Y.J. Marginal dietary copper restriction induces cardiomyopathy in rats. J. Nutr. 2005;135:2130–2136. doi: 10.1093/jn/135.9.2130.

8. Elsherif L., Wang L., Saari J.T., Kang Y.J. Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice. J. Nutr. 2004;134:855–860. doi: 10.1093/jn/134.4.855.

Copper: An Essential Trace Element for Cardiac Longevity

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Detoxifying Gerontogens To Reverse Biological Age

By: Lindsay Christensen MS, CNS, LDN

We are used to attributing wrinkles, sunspots, and gray hairs - classic signs of aging - to the usual lifestyle suspects of UV exposure, chronic stress, and lack of sleep, but there is something else at play that we are losing site of: Toxin Exposure and Toxic Burden. The human “exposome” is de ned as the milieu of toxins to which we are exposed across our lifetime, and this exposome can accelerate biological aging by in uencing internal biological processes that drive deterioration of human health. In fact, certain toxins are such signi cant drivers of aging that they have been endowed with a speci c name: “Gerontogens.”1 “Gerontogens” include air pollution (nitrogen dioxide and PM2.5), smoking, lead, and aluminum, among many others.2,3,4

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Understanding proper detoxi cation may be the single most fundamental principle for healthy aging and longevity and supporting the body’s detoxi cation system to clear gerontogens must be done before other anti-aging therapies as toxins become impediments to their success.

Our Unprecedented Exposure to Toxins and Their E ects on Aging

We live in an increasingly toxic world rife with chemical exposures of a magnitude that our bodies have never before experienced in human history. Emerging research suggests that certain toxins may adversely a ect the course of biological aging. Examples include heavy metals, air pollution, BPA and BPA alternatives such as BPS and BPF, phthalates, microplastics, mycotoxins, and the herbicide glyphosate.

Our toxic burden taxes the body’s antioxidant systems, which has been shown to drive biological aging by harming mitochondria, damaging cell and organelle membranes, draining NAD+ levels, interfering with healthy sirtuin and telomere function, and causing chronic cellular senescence and neuroendocrine dysfunction.5,6,7,8,9,10,11

Which toxins disrupt our biochemistry?

• Acetaminophen, antibiotics, and heavy metals have been shown to actively disruptmitochondrial energy production and increase production of reactive oxygen species (ROS).12,13,

• Particulate matter, pesticides, heavy metals, antibiotics, and non-native electromagnetic elds (EMFs) disrupt cell and organelle membranes, impairing cellular function.14,15,16,17

• Metals like methylmercury and endogenous toxins like lipopolysaccharide (LPS) derived from Gram-negative gut bacteria can deplete NAD+ levels and block sirtuin activation, accelerating biological aging. 18,19

Understanding proper detoxi cation may be the single most fundamental principle for healthy aging and

longevity. By regularly supporting the Nrf2 pathway, we can unload the body’s toxic burden to set the stage for possibly slowing and even reversing the biological pace of aging.

Nrf2 for Healthy Aging

Nuclear factor erythroid 2-related factor (Nrf2) is a transcription factor, a protein that helps turn genes “on” or “o ” by binding to sections of DNA. It resides in the cytosol of cells and, upon sensing oxidative= stress, translocates to the nucleus, where it attaches to the promoter region of genes that encode= critical elements of detoxi cation known as the antioxidant response element (ARE).

Nrf2-mediated activation of the ARE protects the body against oxidative stress and repairs DNA damage triggered by environmental toxins, in uencing two critical drivers of aging.20 We like to think that the body has everything it needs to employ e ective detoxi cation naturally, but ironically, toxin exposure and toxic burden impedes the body’s natural ability to detox by interfering with Nrf2 signaling.

Because of this, we need to actively support Nrf2 with speci c nutraceutical interventions.

A Better Way to Support Detoxi cation

and Nrf2

Toxin exposure is a modi able risk factor for aging, amenable to detoxi cation interventions that support the Nrf2 signaling pathway.21 Activation of Nrf2 supports glutathione synthesis, a cornerstone of detoxi cation. There are a variety of well-researched nutraceuticals that activate Nrf2 to facilitate detoxi cation, but many su er from low bioavailability.

A successful detoxi cation program is an essential rst step in a patient’s longevity

journey and hinges on ‘biosynchronous activation™’, the concurrent delivery of key ingredients into the body using speci c delivery technology to enhance bioavailability and elicit speci c and powerful biochemical actions in a synchronized and timely way.

Biosynchronous Activation™ in detoxi cation is dependent on two critical factors:

1. Utilizing the right combination of Nrf2-upregulating and detoxi cation support compounds

2. Delivery technology to increase bioavailability and activation of ingredients

Nrf2 and Detoxi cation Compounds

Glutathione

Nrf2 regulates the synthesis of glutathione, the body’s master antioxidant, and a vital detoxi cation molecule. Nrf2 regulates two enzymes involved in glutathione synthesis: Glutathione reductase and glutathione synthetase.22,23 Glutathione is needed for Phase I and Phase II of detoxi cation, in which chemicals are activated and then conjugated in preparation for elimination. A lack of glutathione availability slows down detoxi cation. The agerelated decline in Nrf2 activity is one reason why glutathione synthesis, and possibly detoxi cation capacity, may decline with age.24

Lipoic Acid

Lipoic acid is a sulfur-based compound that functions as an antioxidant in part through Nrf2 activation.25 Upregulation of Nrf2 by lipoic acid protects against heavy metal toxicity.26 Through its detoxifying and antioxidant e ects, lipoic acid may reduce in ammation and oxidative stress during the aging process.

Milk Thistle

Milk thistle (Silybum marianum), a prickly plant from the Asteraceae (Daisy) family, has an extensive history of use in traditional Western herbalism for supporting the liver, the body’s detox “hub.” Milk thistle contains several bioactive phytochemicals that upregulate Nrf2 and support detoxi cation, including silymarin.27 Flavolignan constituents of milk thistle have been shown to protect against a variety of chemical assaults, including arsenic, paraquat, and acrylamide, through Nrf2 bioactivation.27

DIM

Diindolylmethane is a sulfurous phytochemical found in cruciferous vegetables such as broccoli, cauli ower, cabbage, and kale. It also upregulates Nrf2 activity, protecting against oxidative stress that advances biological aging.28

Bitter Herbs

Bitter herbs can assist detoxi cation by stimulating bile ow and membrane proteins involved in Phase III detoxi cation, facilitating the movement of toxins out of cells, into bile, and out of the body via stool. Several bitter herbs also act on the Nrf2 pathway. For example, the bitter herb dandelion enhances bile ow and upregulates the Nrf2 antioxidant pathway.29,30 Myrrh, a resinous substance derived from the Commiphora mukul tree native to India, supports healthy bile ow by increasing the expression of the human bile salt export pump and enhances Nrf2 expression.31

Nanoparticle Delivery Technology for E ective Detoxi cation

Nutrient cofactors and phytonutrients have the potential to support core detoxi cation pathways inside the body and clear the way for healthy aging. However, the poor bioavailability

of many of these substances hinders cellular uptake and absorption creating an impediment to e ective intracellular detoxi cation.

To maximally support detoxi cation, we must improve the bioavailability of these compounds. The delivery system in which we “package” nutrient cofactors and phytonutrients can make a remarkable di erence in how these bene cial compounds are processed by the body and used to support detoxi cation. Nanoparticle delivery systems, including liposomes and nanoemulsions, o er a solution to the bioavailability problem and support a more rapid and e ective detoxi cation process.33

Liposomes are tiny bi-layered lipid bubbles approximately the width of a single human hair made of the same fats – phospholipids – as our own cell membranes. The two phospholipid layers of a liposome form concentrically; the outer layer has hydrophilic “water-loving” phospholipid heads at the surface, allowing the particle to mix with water. The molecule’s core contains hydrophilic heads that face inward, allowing the liposome to carry watersoluble ingredients. Liposomal delivery systems can improve the bioavailability of water-soluble detoxi cation nutrients, including glutathione.32

Nanoemulsions, on the other hand, are monolayered spheres that carry fat-soluble ingredients. They are composed of a singlelayer membrane of phospholipid molecules with the hydrophilic head facing the outside and the hydrophobic tail on the inside. These droplets have a large surface area and volume and, like liposomes, signi cantly enhance the bioavailability of the therapeutic phytonutrients and vitamins they contain. As suggested by their structure, they work best for carrying fat-soluble ingredients such as vitamin D and carotenoids.33

The structure of liposomes and nanoemulsions enables rapid and synchronized cellular

absorption of these molecules across lipid membranes, avoiding the unpredictability of digestion, providing unparalleled support for intracellular detoxi cation. Rapid delivery of bioavailable detoxi cation ingredients through nanoparticle delivery systems supports biosynchronous activation™, creating e ective and predictable detoxi cation protocols to remove gerontogens and other toxic elements clearing the way for healthy aging.

1 Sorrentino JA et al. De ning the toxicology of aging. Trends Mol Med. 2014; 20(7): 375-384.

2 Ward-Caviness CK et al. Long-term exposure to air pollution is associated with biological aging. Oncotarget. 2016;7(46): 7451074525.

3 Eid A and Zawia N. Consequences of lead exposure, and it’s emerging role as an epigenetic modi er in the aging brain. Neurotoxicology. 2016; 56: 254-261.

4 Bondy SC et al. Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration. Toxicology. 2014; 315: 1-7.

5 Kitaoka Y et al. E ects of Nrf2 de ciency on mitochondrial oxidative stress in aged skeletal muscle. Physiol Rep. 2019; 7(3): e13998.

6 Itri R et al. Membrane changes under oxidative stress: the impact of oxidized lipids. Biophys Rev. 2014; 6(1): 47-61.

7 Xie N et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020; 5: 227.

8 Santos L et al. Potential modulation of sirtuins by oxidative stress. Oxid Med Cell Longev. 2016; 2016: 9831825.

9 Barnes RP et al. The impact of oxidative DNA damage and stress on telomere homeostasis. Mech Ageing Dev. 2019; 177: 37-45.

10 Liguori I et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13: 757-772.

11 Joergensen A et al. Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans. PLoS One. 2011. https://doi.org/10.1371/journal. pone.0020795

12 Sun N et al. The mitochondrial basis of aging. Mol Cell. 2016; 61(5): 654-666.

13 Cunningham Z et al. Clinical e ects of chemical exposures on mitochondrial function. Toxicology. 2017; 391: 90-99.

14 Chew S, et al. Impairment of mitochondrial function by particulate matter: Implications for the brain. Neurochem Int. 2020; 135(104694).

15 Zulki i-Cunningham Z, et al. Clinical e ects of chemical exposures on mitochondrial function. Toxicology. 2017; 391: 9099.

16 Kalghatgi S, et al. Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells. Sci Transl Med. 2013; 5(192): 192ra85.

17 Santini SJ, et al. Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems. Oxid Med Cell Longev. 2018; 2018: 5076271.

18 Caito SW et al. NAD+ supplementation attenuates methylmercury dopaminergic and mitochondrial toxicity in Caenorhabditis Elegans. Toxicol Sci. 2016; 151(1): 139-149.

19 Xie N et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020; 227

20 Matsumaru D and Motohashi H. The KEAP1-NRF2 system in healthy aging and longevity. Antioxidants (Basel). 2021; 10(12): 1929.

21 Misra BB et al. The chemical exposome of human aging. Front Genet. 2020; 11: 574936.

22 Harvey CJ et al. Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress. Free Radic Biol Med. 2009; 46(4): 443-453.

23 Steele ML et al. E ect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox Biol. 2013; 1(1): 441-445.

24 Suh JH et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. PNAS. 2004; 101(10): 3381-3386.

25 Lee J et al. α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway. PLoS One. 2019; 14(12): e0226769.

26 Hossain KFB et al. Amelioration of metal-induced cellular stress by α-lipoic acid and dihydrolipoic acid through antioxidative e ects in PC12 cells and caco-2 cells. Int J Environ Res Public Health. 2021; 18(4): 2126.

27 Vargas-Mendoza N et al. Flavolignans from Silymarin as Nrf2 bioactivators and their therapeutic applications. Biomedicines. 2020; 8(5): 122.

28 Lay-Lay Saw C et al. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2- mediated Phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos. 2011; 32(5): 289-300.

29 Gonzalez-Castejon M, et al. Diverse biological activities of dandelion. Nutr Rev. 70(9): 534-547.

30 Esatbeyoglu T, et al. Sesquiterpene lactone composition and cellular Nrf2 induction of Taraxacum o cinale leaves and roots and Taraxinic Acid β-d-Glucopyranosyl Ester. J Med Food. 2017; 20(1): 71-78.

31 Lebda MA, et al. Commiphora myrrh supplementation protects and cures ethanol-induced oxidative alterations of gastric ulceration in rats. Antioxidants (Basel). 2021; 10(11): 1836.

32 Sinha R, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018; 72(1): 105-111.

33 Banasaz S, et al. Encapsulation of lipid-soluble bioactives by nanoemulsions. Molecules. 2020. 25(17): 3966.

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New Model Shows Link Between Telomere Length and Risk of COVID-19 Mortality

By: Joseph M. Ra aele MD

The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), a zoonotic, single-stranded positive RNA virus that first emerged in Wuhan, China in late 20191 As of August 2022, the World Health Organization (WHO) has confirmed over 577 million cases and 6.4 million deaths from COVID-19 worldwide.2

The fatality ratios for SARS-CoV-2 infections are highest among the elderly (≥80 years) and range from 8% to 36%.3, The findings suggest that age-related mechanisms, such as the progressive shortening of telomere length with age, may play an integral role in the severity and mortality of COVID-19.

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

According to a recent study from University of Washington, short hematopoietic cell telomere length (HCTL) may be why vulnerability to COVID-19 increases dramatically among the elderly.5 Without adequate clonal expansion capacity, a process dependent on telomere length, these populations may be at risk of developing a shortfall in T-cells, leading to lymphopenia and severe disease.6,7,8

Telomere Length and Its Importance in the Fight Against COVID-19

Telomeres are specialized structures that cap the end of chromosomes, protecting them from damage and providing genomic integrity.9 In addition to their protective role, telomeres can be considered aging clocks in cells. Every time cells undergo mitosis (cell division), telomeres also follow suit – to an extent. Telomeres get shorter with each division until they reach a point at which they are unable to bind telomerecapping proteins. Because they are then sensed as exposed DNA ends, a DNA damage response is triggered, ultimately resulting in cellular senescence and cessation of replication.10

In recent years, telomere length has been recognized as one of the best biomarkers of an organism’s biological age as well as aging-related pathological conditions.11 Its attractiveness as a biomarker of aging includes:12

• Its correlation with chronological age across an organism’s lifespan

• Its predictive power of one’s susceptibility to a disease and mortality

• Its responsiveness to various exposures (adverse and beneficial)

• Its ability to be used to track changes in human aging rate

Telomere length is a heritable trait that displays relatively robust synchrony among all human leukocytes and hematopoietic cells.13

For example, people with long telomeres in one leukocyte subset have relatively long telomeres in other leukocyte subsets.

Apart from genetics, no other factor has a bigger impact on telomere length than aging. Older people tend to have a higher inflammatory

response to antigens, a phenomenon coined ‘inflammaging.’ Aging of the immune system also drains the proliferative capacity of telomere length-dependent T-cells, which then affects the ability to suppress infections.14

These effects are particularly evident in a SARS-CoV-2 infection, in which the body is confronted with the demand for massive clonal expansion of T-cells to offset the lymphopenia that arises from falling T-cell counts.15,16

One study from Belgium compared the telomere lengths of 70 hospitalized patients with COVID-19 to those of 491 healthy volunteers. Froidure and colleagues found that a significant proportion of patients had short telomeres (<10th percentile) compared to the reference cohort. Short telomeres were linked to greater disease severity, defined as ICU admission or death without ICU.17

Moreover, developing immunity to SARSCoV-2 requires naive T-cells to proliferate and differentiate into SARS-CoV-2-antigenspecific effector/memory T-cells.16,18 Based on this evidence, the authors of the current study speculate that short telomeres in naive T-cells may also impede adaptive immunity to the infection even without lymphopenia.

Developing the Model

Anderson and colleagues developed a model examining the relationship between age-related decline in telomere length-dependent T-cell clonal expansion capacity with COVID-19 mortality.

To build the model, they used records from the Centers for Disease Control and Prevention (CDC) and the 2019 U.S. Census for COVID-19 and non-COVID-19 mortalities as well as data from studies whose HCTL had been measured prior to the pandemic.4

New Model Shows Link Between Telomere Length and Risk of COVID-19 Mortality

The team made the following assumptions about T-cell replication, telomere length, and T-cell clone size for their model:

● The “telomeric brink” (TLB) or the point of telomere length-dependent termination of T-cell replication, is 5 kb.

● The length of a telomere in a naive T-cell at age 20 (TL20) shortens at a rate of 0.03 kb/ year until it reaches the telomeric brink.

● A naive T-cell can generate a maximal clonal size of 220 (approximately 1 million) T-cells through 20 replications.

● Most memory T-cells are formed during childhood and early adulthood, periods during which maximal clonal size can be achieved due to long HCTL.

● “Telomeric onset” (TLO) or the shortest T-cell telomere length that can achieve maximal clonal size, is 6.4 kb. A naive T-cell reaches telomeric onset at the “age of onset,” after which it can only generate a limited clonal size because a full expansion drops the telomere length below the telomeric brink. Telomere length contributes to the telomeric onset, i.e., long T-cell telomeres reach it at a later age of onset compared to shorter T-cell telomeres.

Results

According to the model, naive T-cells are capable of generating the maximal clonal size (MCS) of 220 memory T-cells in response to an antigen before the age of onset (X0). But their ability to do so declines in an exponential manner once this age is reached. In one decade after the age of onset, the naive T-cells’ clonal expansion capacity was shown to be only 5% of the maximal clonal size

Figure 1

Source: https://www.ncbi.nlm.nih. gov/pmc/articles/PMC8970968/

Specifically, a person with an average HCTL can attain maximal clone size up to the age of 50. Plots generated using the model suggest that limited clonal size is roughly equivalent to maximal clonal size. After that, however, naive T-cells rapidly decline in their clonal expansion capacity, coinciding with the dramatic increase in COVID-19 mortality among the elderly.

Figure 2 shows the population distribution of TL20 and agedependent changes in T-cell telomere length and in T-cell clone size. Figure 2

Population distribution of T-cell TL at age 20 (TL20), T-cell TL shortening with age, and agedependent change in T-cell clone size (CS). (a) displays the TL20 distribution, showing mean TL = 7.3 kb ( ), long TL (mean + SD) = 7.9 kb ( ), and short TL (mean – SD) = 6.7 kb ( ). (b) displays age-dependent change in T-cell for mean, long and short TL20. Past the telomeric onset (TLO = 6.4 kb), TL is insufficient to produce MCS because a full clonal expansion drops TL below the telomeric brink (TLB = 5 kb). The TLO is reached at different ages of onset (XO), i.e., an older age for T-cells with long T-cell telomeres and younger with T-cells with short telomeres. The age-dependent T-cell TL shortening (0.03 kb/year) for T cells with mean, long, and short telomeres at TL20 is shown by the lines. (c) shows that the T-cell CS is partitioned by the XO into plateau and slope regions. T cells with mean, long, or short TL20 achieve MCS on the CS plateau, but their CS exponentially collapses (slope) once their TLs shorten below TLO and exceed XO (at different ages).

Source: https://www.ncbi.nlm.nih. gov/pmc/articles/PMC8970968/

The plots in Figure 2 were used to describe Figure 3, which displays the shifts in naive T-cell telomere length distribution and relative frequency of T-cell clone size in the population. In the distribution graphs, the blue and red bars indicate telomere lengths that fall below and above the telomeric onset, respectively. As shown, the proportion of the population with telomere lengths above the telomeric onset declines with age, falling to just 10% at age 70.

The bar graphs in Figure 3 show the relative frequency of the clonal size formed by naive T-cell clonal expansion. The maximal clonal size occurs in 9 out of 10 individuals at the age of 20, in whom naive T-cell telomere length is greater than the telomeric onset. In

contrast, at age 70, less than 2 out of 10 people can generate the maximal clonal size.

Figure 3

Source: https://www.ncbi.nlm.nih. gov/pmc/articles/PMC8970968/

Perhaps the most exciting finding from this study was that the model was also able to explain the high variability in age of onset across a population. Because telomere length is heritable, there are differences in their lengths between people at every age, and the age of onset can also vary between individuals.

For example, an individual with long T-cell telomeres may be able to achieve maximal clonal size up to 70 years of age, while someone with short telomere lengths is able to do so up until they’re 30 years old. This finding suggests that younger adults who develop severe COVID-19 may have done so due to their short T-cell telomere length, which limited their ability to achieve maximal clonal size in the face of the infection.

What Does the Model Tell Us About Telomere Length and COVID-19 Mortality?

The COVID-19 pandemic has highlighted the role of telomere length on mortality from agingrelated disease. A SARS-CoV-2 infection presents two levels of challenges: creating SARS-CoV-2specific memory T-cells and replenishing lost naive

New Model Shows Link Between Telomere Length and Risk of COVID-19 Mortality

T-cells. Both of these processes depend on HCTL, which shorten naturally with age and thereby limit the clonal expansion capacity of T-cells.

The insights gained from this model may help healthcare practitioners use telomere length parameters to identify individuals who may be most susceptible to severe COVID-19. These individuals may also show early waning of

immunity after a SARS-CoV-2 vaccination, leaving them vulnerable to a novel variant of the virus.

By identifying patients with short telomeres, healthcare professionals may be able to better stratify risk of severe COVID-19 and allocate resources such as booster vaccines, antivirals, and monoclonal antibodies more effectively than by relying on chronological age alone.

Author Bio:

Joseph M. Raffaele, MD

Joseph Raffaele received his BA in philosophy from Princeton University and his MD from Hahnemann University Medical School in 1989. Dr. Raffaele did his internal medicine residency at The New York Hospital/Cornell University Medical Center and was formerly a clinical assistant professor of medicine at Dartmouth Medical School while in practice at the Hitchcock Clinic. Dr. Raffaele is a member of the American College of Physicians, is board

References:

1. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern [published correction appears in Lancet. 2020 Jan 29;:]. Lancet. 2020;395(10223):470473. doi:10.1016/S0140-6736(20)30185-9

2. WHO coronavirus (COVID-19) dashboard. World Health Organization. https://covid19.who.int/. Accessed August 3, 2022.

3. Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis [published correction appears in Lancet Infect Dis. 2020 Apr 15;:] [published correction appears in Lancet Infect Dis. 2020 May 4;:]. Lancet Infect Dis. 2020;20(6):669-677. doi:10.1016/S14733099(20)30243-7

4. US Census Bureau. American Community Survey (ACS). Census. gov. Published March 13, 2019. https://www.census.gov/ programs-surveys/acs/

certified in internal medicine, and is a diplomate of the American Academy of Anti-aging Medicine.

In 1995 Dr. Raffaele began researching and developing a scientifically-based treatment program and co-founded PhysioAge Medical Group. Since 1997 Dr. Raffaele has been focused on age longevity medicine and biomarkers of aging.

5. Anderson JJ, Susser E, Arbeev KG, et al. Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality. EBioMedicine 2022;78:103978. doi:10.1016/j.ebiom.2022.103978

6. Aviv A. Telomeres and COVID-19. FASEB J. 2020;34(6):72477252. doi:10.1096/fj.202001025

7. Aviv A. Short telomeres and severe COVID-19: The connection conundrum. EBioMedicine. 2021;70:103513. doi:10.1016/j. ebiom.2021.103513

8. Benetos A, Lai TP, Toupance S, et al. The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19. J Gerontol A Biol Sci Med Sci. 2021;76(8):e97-e101. doi:10.1093/gerona/glab026

9. Telomere. Genome.gov. https://www.genome.gov/geneticsglossary/Telomere

10. Rossiello F, Jurk D, Passos JF, d’Adda di Fagagna F. Telomere dysfunction in ageing and age-related diseases. Nature Cell Biology. 2022;24(2):135-147. doi:10.1038/s41556-022-00842-x

11. Vaiserman A, Krasnienkov D. Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives. Frontiers in Genetics. 2021;11. doi:10.3389/ fgene.2020.630186

12. Hastings WJ, Shalev I, Belsky DW. Translating Measures of Biological Aging to Test Effectiveness of Geroprotective Interventions: What Can We Learn from Research on Telomeres?. Front Genet. 2017;8:164. Published 2017 Nov 22. doi:10.3389/fgene.2017.00164

13. Kimura M, Gazitt Y, Cao X, Zhao X, Lansdorp PM, Aviv A. Synchrony of telomere length among hematopoietic cells. Exp Hematol. 2010;38(10):854-859. doi:10.1016/j. exphem.2010.06.010

14. Nikolich-Žugich J. The twilight of immunity: emerging concepts in aging of the immune system [published correction appears in Nat Immunol. 2018 Oct;19(10):1146]. Nat Immunol. 2018;19(1):10-19. doi:10.1038/s41590-017-0006-x

15. Diao B, Wang C, Tan Y, et al. Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19). Front Immunol. 2020;11:827. Published 2020 May 1. doi:10.3389/fimmu.2020.00827

16. Rydyznski Moderbacher C, Ramirez SI, Dan JM, et al. AntigenSpecific Adaptive Immunity to SARS-CoV-2 in Acute COVID19 and Associations with Age and Disease Severity. Cell 2020;183(4):996-1012.e19. doi:10.1016/j.cell.2020.09.038

17. Froidure A, Mahieu M, Hoton D, et al. Short telomeres increase the risk of severe COVID-19. Aging (Albany NY). 2020;12(20):19911-19922. doi:10.18632/aging.104097

18. Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 2021;184(4):861-880. doi:10.1016/j. cell.2021.01.007

New Model Shows Link Between Telomere Length and Risk of COVID-19 Mortality

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7062

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Oligoscan (Springdale Health Management) ............. 3114

Olympia Pharmacy 7033

Omega Diagnostics Ltd .............................. 3099

OmegaQuant 2060

Optimal Health Systems .............................. 1064

Ortho Molecular Products 4027

OutcomeMD ....................................... 6007

Outset 9032

OxyHealth ......................................... 6021

Pathways Bioscience 3103

PCCA .............................................. 6091

Pellecome LLC 3039

PEMF Systems, Inc. .................................. 8047

Pharmalink 8044

Physician Compounding Alliance llc .................... 9038

Physicians Lab 1018

Physicians Preference Pharmacy ...................... 8090

Podcasting and Videos Made Easy 8021

Power2Practice ..................................... 7039

Precheck Health Services Inc. 3102

Precision Compounding Pharmacy

X Vintage Labs Collection 9026

Precision Point Diagnostics 6099

Prestige Products Direct 9043

Prevencio, Inc. 9016

Prism Light Pad 6047

Prism Light Pod 5046

PRMEDICA, Inc. 2081

ProCBD by CV Sciences 3066

Prodrome Sciences 3037

Progressive Medical 8032

PromoItalia LLC 2049

Prosoma LLC 3091

Protocol For Life Balance 8043

PureWave Technologies 1024 Qest, LLC 6039

Qualgen 4100

Qualia by Neurohacker 1044

Quartermaster Tax Management, LLC 6100

Quest Cardiometabolic Center of Excellence 7090

Quicksilver Scientific 5021

Rapid Release Technology 2038

Recharge Biomedical 7091

Refine USA 8046

Regenative Labs 3084

RegenLab USA 7084

Rejuvenation Science 4039

Relax Saunas 9041

Relicus Medical Holdings LLC 5043

Researched Nutritionals® 6073

Revelation Pharma 8033

RGS Healthcare / Save Your Throid 5100

Rupa Health 3021 Rx Harmony 8078

SALT Chamber Inc. 8089

Sanesco 1048

SaunaSpace ........................................ 2085

Scarf King Foyer

Sciton ............................................. 5079

seca 7060

See Beyond Medicine ................................ 3061

Selphyl PRP/PRFm 1040

SilverCeuticals Inc. .................................. 7064

Sinclair 6042

Skin Type Solutions .................................. 3090

SmartGraft by Vision Medical, Inc. 4093

Softwave TRT ....................................... 8098

Sofwave 3064

SRW Laboratories 1050

Standard Process .................................... 8027

Stellar Biomolecular Research 4086

Strive Compounding Pharmacy ........................ 2045

Symphony Natural Health 8080

TA Sciences ........................................ 5007

Tailor Made Compounding 4064

Tatt2Away by Rejuvatek Medical Inc.................... 1058

Texas Star Pharmacy 2093

The Functional Medicine Project ...................... 3045

The Institute of Regenerative Medicine 5091

Thera Wellness Solutions, Inc.......................... 8104

THOR Photomedicine 6043

Thrivv LLC.......................................... 6061

Timeline Nutrition 1039

Trocar Supplies ...................................... 9025

Troscriptions 4102

TruDiagnostics 7094

Uberlube ........................................... 2071

Ulta Lab Tests 3036

University Compounding Pharmacy .................... 4013

Uriel Pharmacy 3060

US Biotek Labs ...................................... 6037

Vertisis Custom Pharmacy 7100

Vibrant Wellness .................................... 8038

Viola Threads 7048

Vita Aid Professional Therapeutics ..................... 7049

Vital Proteins 2039

VitalRemedyMD Inc. ................................. 3094

Vitelle Labs 6033

Vivos Therapeutics .................................. 7093

Ward Photonics 2032

Wavi Medical ....................................... 1066

Well ProZ 8036

Wellness Clinic Marketing ............................ 7043

Wellness Pharmacy 1036

Wells Pharmacy Network............................. 1062

WholeScripts 1055

Women’s Hormone Network. Inc. ..................... 9055

World Insurance Associates 2046

Xtend-Life Group Limited ............................ 1060

Y LIFT 4047

Young Goose ....................................... 1063

Zimmer MedizinSystems 7099

Zion Healing Inc. .................................... 3085

Zizion Inc. 5085

ZRT Laboratory ..................................... 7007

LISTINGS

1LifeScience,

Booth #7098

LLC

5110 N 32nd St,Ste # 105 Phoenix, Arizona, 85018 | USA

Ph: (602) 614-4938

Email: joshuadtully@gmail.com www.1lifescience.com

1LifeScience is an innovator in the Longevity space with our flagship line of NMN formulations. Products are formulated for clinical efficacy. Additionally, we provide a full line or supplements, CBD, and sports nutrition products. Each product is rigorously tested through our GMP policies to ensure quality and potency. We strive whenever possible to adhere to organic, vegan, non-gmo, Kosher, Halal, ISO guidelines.

4Ever Young Anti-Aging Booth #2067

5458 Town Center Rd. Ste # 19, Boca Raton, Florida, 33498 | USA

Ph: (561) 320-8111

Email: info@fyinstitute.com www.4everyoungantiaging.com

4Ever Young is a vitality center that offers a wide range of Anti-Aging solutions, medical aesthetics, like Botox and dermal fillers, hormone replacement therapy, IV Vitamin therapy, Skin Services, like Microneedling and HydraFacial, weight loss, nutraceutical therapy and total body wellness.

AC Grace Company Booth #2033

PO Box 570, Big Sandy, Texas, 75755 | USA

Ph: (800) 833-4368

Email: info@acgrace.com www.acgrace.com

Providing the Highest quality Products, Unique E “The Natural Choice” Since 1962

Access Medical Labs

Booth #2013

5151 Corporate Way, Jupiter, Florida, 33458 | USA

Ph: (866) 720-8386

Email: info@accessmedlab.com www.accessmedlab.com

Access is the nation’s premier specialty diagnostic lab. We offer a broad menu of testing from blood, saliva, urine & swab samples. We perform all of your tests in our 25,000 sq. ft. ultra-automated facility in Jupiter, Florida & provide results within 24hrs. Since 2003, we continuously strive to innovate, inspire and improve solutions for physicians by providing an exceptional personalized experience with the most accurate testing.

Acella Pharmaceuticals

Booth #7046

1880 McFarland Pkwy,Suite 100 Alpharetta, Georgia, 30005 | USA

Ph: (678) 325-5189

Email: kdunlop@acellapharma.com www.acellapharma.com

Acella Pharmaceuticals, LLC is a specialty pharmaceutical company committed to innovating the healthcare field by bringing quality and affordable products to our customers and patients.

ACIGI Relaxation Booth #3067

4399 Ingot Street, Fremont, California, 94538 | USA

Ph: (510) 651-9088

Email: marketing@drfuji.com www.fujichair.com

Dr. Fuji Health & Wellness massage equipment, is the fruit of further evolution of intelligent pneumatic and mechanical milt-technology designed to partner with medical and health professionals in their clinical stress managements.

ADigital Health

Booth #1049

840 US-1 N,Ste.435M

North Palm Beach, Florida, 33408 | USA

Ph: (561) 247-3839

Email: info@adigitalhealth.com www.adigitalhealth.com

ADigital Health is a remote patient care and monitoring platform that helps doctors automate care instructions and manage patients between encounters to improve patient outcomes and increase practice revenue. Easily enroll patients into care programs so patients receive your guidance and instructions everyday. Patients can track progress including body metrics, calories, steps, activity, water, sleep and more. Provide better care and support in a fraction of the time, right from the palm of your hand.

ADIT

Booth #4090

1440 Columbia St,Apt 503

San Diego, California, 92101 | USA

Ph: (281) 675-2450

Email: sonam@adit.com

Digital Marketing With A Guarantee. Life comes with very few guarantees. Luckily, Adit’s digital marketing is one of them! We understand that we need to earn your trust. That’s why we have confidence in our team’s expertise and ability to help you achieve your goals by absorbing the upfront risk, so you won’t have to. If our dental digital marketing services don’t deliver results within the first 30 days, we won’t charge you a single penny, guaranteed.

Aerodiagnostics

Booth #1046

561 Virginia Road,Suite 100

Concord, Massachusetts, 1742 | USA

Ph: (844) 681-9449

Email: kmagoon@aerodiagnostics.com www.aerodiagnostics.com

Aerodiagnostics was founded on the principles of customer service and convenience. We offer convenient non-invasive hydrogen and methane breath collection kits that can be used in the comfort of your patients home or place of employment. Our goal is to provide you with highly accurate tests in a collection environment that is convenient.

Aerolase

Booth #3071

120 White Plains Road, Tarrytown, New York, 10591 | USA

Ph: (914) 345-8300

Email: contact@aerolase.com www.aerolase.com

Aerolase develops scalable, leading-edge devices for forward-thinking medical professionals who want to deliver top-of-the-line therapies, experiences, and results for the skin. Built on 25 years of research and development, our lasers substantially improve treatment outcomes, patient experiences, and bottom-line revenue. Take your patient results and experiences further for everything you can imagine skin-related. No matter who you are, who your patients are, or what your specialty is, Aerolase will make the incredible happen.

515 E. Las Olas Blvd.,,Suite 120 Fort Lauderdale, Florida, 33301 | USA

Ph: (888) 610-3068

Email: affordableantiaging@protonmail.com www.affordableantiagingcenter.com

Our company brings an accessible and innovative science-based program to physicians’ offices to increase patients’ health span. We offer a 360º approach to anti-aging by using advanced diagnostic technology and systems that help to slow and even reverse the aging process in an affordable and effective way.

AgelessLX

Booth #8034

135 W. Main Street,Ste. B Missoula, Montana, 59802 | USA

Ph: (833) 337-9355

Email: michele@agelesslx.com www.AgelessLX.com

Help your patients achieve Drastically Noticeable results with serious anti-aging nutritional products and a proven turn-key lifestyle intervention. Thousands of patient testimonials, 6 US patents and over 40 clinical studies. Visit booth #8034 to sample great tasting nutritional supplements with proven results and high compliance. We are literally Changing The Way Women Age with AgelessLX!

AlgaeCal Inc.

Booth #6092

1286 Homer Ave.,Ste. 200 Vancouver, British Columbia, V6B 1C6 | Canada

Ph: 844-618-1700x2

Email: bruce@algaecal.com www.algaecal.com/hcp

AlgaeCal is the ONLY calcium formula supported by 3 clinical studies to INCREASE bone density. Our exclusive red algae provides over a dozen bone-essential minerals. Our companion product Strontium Boost helps speed bone-building while also improving bone quality.Stop by our booth for a free gift (while supplies last) that reveals the latest bone-health research and provides a roadmap to offer your patients better bone-health outcomes. Or contact us at hcp.algaecal.com or 1 (844) 618-1700.

Allergy Research Group

Booth #4060

2300 S. Main Street, South Salt Lake, Utah, 84115 | USA

Ph: (800) 545-9960

Email: emily.gerke@allergyresearchgroup.com www.allergyresearchgroup.com

Since 1979, Allergy Research Group® has been providing healthcare practitioners with the highest quality, cutting-edge nutritional supplements. We maintain strict quality control procedures and source ingredients with the lowest possible allergy potential to meet the health needs of your most sensitive patients. Allergy Research Group’s mission is to positively impact lives by partnering with practitioners providing leading edge education, scientifically based innovation, ingredient purity, and a culture of service.

Alletess Medical Laboratory

Booth #9013

14 Howard Street, Rockland, Massachusetts, 2370 | USA

Ph: 800-225-5404x312

Email: ksaccone@foodallergy.com www.foodallergy.com

Alletess Medical Laboratory has provided allergy and immunology testing services to healthcare practitioners worldwide for 4 decades. Our test offerings include IgG and IgA food sensitivity testing, panels for autoimmune disorders, allergy testing for molds, inhalants and foods. We have registered dietitians on staff to help guide patients through their journey to better health. Our transparent pricing, unrivaled customer service, and quick turnaround time make us the best choice for your practice.

Alphascience

Booth #6085

91 rue Faubourg, St Honore, Ile-de-France, 75008 | France

Ph: (760) 822-4833

Email: caprice@alphascience.com www.Alphascience.com

Supporting the skin’s own ecosystem for health with ingredients of natural origin and allowing the skin to retain all of its vital force. To achieve this, we are committed to pushing the limits of cosmeceuticals by integrating exclusive ingredients, superior technology and innovation into each of our skin treatments. Formulations by Alfred Marchal, PhD Organic Chemistry.

Ph: (844) 443-2355

Email: info@americancelltechnology.com www.americancelltechnology.com

American

E.

Ph: (626) 307-0928

Email: dr.luke@newvita.com www.newvita.com

We offer a simple & effective system which is Artificial Intelligence in Chinese Medicine® to take care 700 conditions and many difficult cases and to slow down aging process. It includes Meridian Energy Analysis, Nano Herbs, Nano Vita Water and acupuncture without needles---Nano Herbs Light. One-day training class, book “CHINESE MEDICINE MADE SIMPLE” are available. Dr. Luke Cua will provide TCM service on site.

American Wellness Group Inc

Booth #7079

200 North Buffulo Dr. Ste 200, Las Vegas, Nevada, 89145 | USA

Ph: (702) 347-7000

Email: info@americanmalewellness.com www.americanwellnessgroup.com

American Wellness Group focuses on advancing wellness health for men and women. We have three different specialized branches for medical wellness and compounding medicine.

Ananda Health Booth #

7013

190 Corporate Blvd., Georgetown, Kentucky, 40324 | USA

Ph: (888) 388-1119

Email: chris.lee@anandahealth.com www.anandaprofessional.com

Ananda Professional is the #1 CBD brand supported by clinical research. With a mission to champion the knowledge, safety and efficacy of CBD products, we’ve invested over $40 million in research to advance the clinical evidence of hemp extract. Our goal is to improve patient outcomes and increase your profitability with lucrative referral programs. From unique product formulations to HCP-specific trainings and tools, everything is geared to make you the CBD experts in your community.

AnazaoHealth Booth #3055

5710 Hoover Blvd, Tampa, Florida, 33634 | USA

Ph: (800) 995-4363

Email: jvillalona@anazaohealth.com www.anazaohealth.com

AnazaoHealth is a national specialty compounding pharmacy. With a 30,000-square-foot 503B FDARegistered Outsourcing Facility in Las Vegas and a 46,000-square-foot traditional 503A compounding pharmacy in Tampa. Both facilities have the appropriate licensure to conduct business in all 50 states, District of Columbia, and selected U.S. territories. AnazaoHealth compounds preparations for Aesthetics, Age Management, Weight Management, IV & Injection Therapy Solutions, Sexual Wellness Solutions, Hormone Replacement, Personalized Hair Care Solutions, Mental Clarity & Acuity &and more.

Anti Aging Bed

Booth #8037

995 W. Kennedy Blvd., Ste.32, Orlando, Florida, 32810 | USA

Ph: (859) 473-1336

Email: chrsthatton111@gmail.com www.antiagingbed.com

The Anti Aging Bed is a new category of wellness. Founded by John Baxter, Anti Aging Beds’ mission is to make the world well again by using our patented information age technology, all from the comfort of home. Our core technology is the grounding mattress cover that neutralizes free radicals by bathing the body with healthy negative ions using conductive nanosilver thread. Also embedded into the fabric is Far infraRed technology that increases oxygen utilization.

Apeiron Zoh

Booth #1043

919 Congress Ave., Ste.525, Austin, Texas, 78701 | USA

Ph: (512) 522-0966

Email: Support@apeironzoh.com www.Apeironzoh.com

Apeiron Zoh is the global leader in epigenetic precision performance human optimization. Dedicated to enhancing the expression of flourishing to more than a billion people across the planet.

Apex Energetics

Booth #9009

16592 Hale Ave., Irvine, California, 92606 | USA

Ph: (800) 736-4381

Email: Inez@apexenergetics.com www.apexenergetics.com

Our motto—Patient Health First™—reflects our mission. It is also our guiding principle that dictates all decisions, from raw material acquisition to manufacturing to our strong practitioner relationships. Over the past 30+ years, we have built a reputation of integrity by infusing everything we do with this principle, and we remain at the forefront of Functional Medicine discoveries and advances with formulations spearheaded by Datis Kharrazian PhD, DHSc, DC, MS, MMSc, FACN.

APYX Medical

Booth #4091

5115 Ulmerton Road, Clearwater, Florida, 33760 | USA

Ph: (800) 537-2790

Email: customerservice@apyxmedical.com www.renuvion.com

Apyx Medical is an advanced energy technology company with a passion for elevating people’s lives through innovative products in the cosmetic market. Known for our Renuvion® cosmetic technology we are focused on one thing: bringing transformative solutions to the customers we serve.

Argentyn 23 by NaturalImmunogenics Booth #5032

7504 Pennsylvania Ave, Sarasota, Florida, 34243 | USA

Ph: 941-702-6100 x 303

Email: seth@n-icorp.com www.Argentyn23.com

Since its launch in 2001, thousands of clinics worldwide have chosen Argentyn 23 Bio-Active Silver Hydrosol™ and First Aid Gel. Argentyn 23 is produced through a proprietary manufacturing technique that results in the smallest particles achievable with greater than 98% positively charged bio-active silver ions and silver nanoclusters. Visit us at our booth to learn more about you can harness the power of silver and copper, our newest hydrosol, in your practice.

Atcor Medical Booth #6071

184 Shuman Blvd., Ste. 515, Naperville, Illinois, 60563 | USA

Ph: (917) 306-1206

Email: info@atcormedical.com www.atcormedical.com

ATCOR develops and markets medical technologies that measure patient risk for hypertension, cardiovascular disease (CVD), and other related vascular disorders. We help clinicians with early detection of target organ damage and management of cardiovascular and renal disease. More than 4,000 ATCOR SphygmoCor®systems are currently in use worldwide at major medical institutions, research institutions, and in various clinical trials with leading pharmaceutical companies. Our technology is featured in over 1,400 peer-reviewed publications in leading medical journals.

AVACEN Medical

Booth #9045

2365 Camino Vida Roble,Unit C Carlsbad, California, 92011 | USA

Ph: (619) 417-8319

Email: djforsgren@avacen.com www.AVACEN.com

AVACEN 100 uses the AVACEN Treatment Method (ATM) – a noninvasive pain management technology platform for people at normal body temperature. AVACEN uses a microprocessor controlled chamber to surround the hand with a slight negative pressure, while adding heat to the palm, gently expanding the volume of blood in the palm’s unique vascular networks while heat is simultaneously transferred from the computer managed palm pad into these expanded vascular networks. FDA Class11,OTC & EU Approved.

AYUMETRIX

Booth #6046

17387 63rd Ave, Portland, Oregon, 97223 | USA

Ph: (503) 819-6676

Email: skapur@ayumetrix.com www.AYUMETRIX.COM

AYUMETRIX is a “smart lab of the future” and has been founded to empower individuals to take charge of their health and wellness using innovative sample collection and laboratory testing technologies. It is a global hormone testing laboratory that partners with clinicians all around the world and offers a practice building package that is inclusive of integrative and functional laboratory testing services, personal health data acquisition/ analysisall under the guidance from industry experts.

Ayush Herbs Inc.

Booth #7062

2239 152nd Ave. NE, Redmond, Washington, 98052 | USA

Ph: (425) 637-1400

Email: cidney@ayush.com www.ayush.com

Ayush Herbs, Inc. was founded in 1988 by Ayurvedic and Naturopathic physicians who believe in healthy living in body, mind and spirit. High quality, organic herbs and years of Ayurvedic wisdom have culminated into a company with a mission of education and creating trusted formulas. Ayush Herbs® is a name that represents quality and purity; for the sake of our customers, our families, and the Ayurvedic community.

Ballancer®Pro USA

Booth #7074

_5090 Richmond Ave # 132, Houston, Texas, 77056 | USA

Ph: (424) 362-7228

Email: info@ballancerpro.com www.ballancerpro.com

The Ballancer®Pro is the most state-of-the-art and safest lymphatic massage technology. Backed by 20 years of clinical studies this FDA-cleared device is “light years” ahead of any others. Trusted by the best doctors in the world this treatment delivers a myriad of benefits, like pain relief, lymphatic drainage, detox, enhanced circulation, optimal health to beauty, and weight loss. The Ballancer®Pro has been coined “The Rolls-Royce of Lymphatic Massage” and guarantees great results every session!

BemerGroup

Booth #7103

116 5100 Anderson Way,Ste # 432

Vernon, British Columbia, V1H 2H7 | Canada

Ph: (250) 308-4766

Email: bmrinfopacket@gmail.com www.behealthy.bemergroup.com

BEMER Therapy is a unique therapy that is delivered via an FDA Class II cleared medical device intended to increase local circulation and muscular performance. BEMER is the only non-invasive, safe and effective Class II Medical Device cleared as a muscle stimulator that uses low intensity and low frequency Pulsed Electromagnetic Fields (PEMF) to achieve the desired therapeutic outcomes. If you want results, then BEMER is for you. Results in 8 minutes twice per day.

Benev Company, Inc.

Booth #2035

23263 Madero.,Suite A

Mission Viejo, California, 92691 | USA

Ph: (949) 457-2222

Email: sales@benev.com www.BENEV.com

BENEV Company Inc. is an FDA registered pharmaceutical and cosmeceutical company, founded in Orange County, California that serves the medical skin care market with scientifically advanced, resultsdriven skin care solutions and medical devices. At BENEV our mission is to inspire a more vibrant life and create a more beautiful world by providing products and services that BENefit EVeryone.

Berkeley Life

Booth #4032

355 East Ohio St.,Ste. 200 Chicago, Illinois, 60661 | USA

Ph: (773) 750-7745

Email: john.halbert@lifes2good.com www.Berkeleylife.com

Berkeley Life Professional’s Nitric Oxide Support products are used by top practitioners around the country. Nitric Oxide is produced naturally by your body. It’s responsible for promoting artery vasodilation which relaxes the muscles in your blood vessels allowing for healthy blood flow and circulation. Berkeley Life’s Nitric Oxide support products include a Dietary Nitrate Supplement, patented Test Strips. Used together, this system provides tools for assessing and supporting Nitric Oxide levels from head to toe.

BHI Rejuve

Booth #8062

214 State Street, Ste. 101, Hackensack, New Jersey, 7601 | USA

Ph: (201) 342-7662

Email: acampbell@mehlingorthopedics.com www.bhirejuve.com

BHI Rejuve is a hormone optimization program designed to help clients reach their full potential. Our program helps restore natural hormone balance by introducing natural hormones into the body. We know that one hormone optimization therapy does not fit all, which is why our bioidentical hormone replacement therapy is personalized for each person’s specific hormone deficiency. At BHI Rejuve, we evaluate each client with an extensive assessment of labs followed by a comprehensive consultation.

BioAntiAge

Booth #1061

72 SE 6 Ave., Delray Beach, Florida, 33483 | USA

Ph: (833) 692-4626

Email: info@bioantiage.com www.BioSculpt.info

BioSculpt shrinks fat and builds muscle by using Magnetic Muscle Stimulation (MMS) technology to force extremely powerful muscle contractions that are not possible with even the most rigorous workouts.

Through practice acquisition and employing talented healthcare providers, we connect the best like-minded practitioners with business experts and a network of collaborative peers.

Become part of a network of physicians who've realized there's more to medicine.

Biocanic, Inc.

Booth #9037

4967 Foothill Blvd., San Diego, California, 92109 | USA

Ph: (619) 867-2318

Email: jeremy@biocanic.com www.biocanic.com

Biocanic is the first of its kind health program intelligence system specifically designed to streamline personalized health programs for integrative physicians. Biocanic helps physicians more effectively design, build and implement personalized health programs by automatically process and centralizing the key lab and assessment data into a single, easy-to-use dashboard. Biocanic currently supports automatic processing of over 80 different lab reports ranging from standard blood chemistry through microbiome, organic acids or advanced hormone tests. www.biocanic.com

Biocidin Botanicals™

Booth #4033

16 Hanger Way,Ste.A Watsonville, California, 95076 | USA

Ph: (831) 786-9711

Email: events@biocidin.com www.biocidin.com

Biocidin Botanicals™ is a leader in botanical supplements and a pioneer in the arena of microbiome health. Its flagship broad-spectrum botanical blend Biocidin® was formulated in 1989 in response to challenging health conditions related to microbial imbalances. More than 30 years later, the company offers a curated line of targeted support products to boost patient health and target the entire GI tract and oral cavity, supporting microbiome balance for healthy digestion and elimination.

Bioclinic Naturals Booth #

9035

#104-3686 Bonneville Place, Burnaby, British Columbia, V3N 4T6 | Canada

Ph: (888) 826-9625

Email: customerservice@bioclinicnaturals.com www.bioclinicnaturals.com

Bioclinic Naturals® is a Canadian nutraceutical manufacturer of a professional product line comprised of fertility kits and supplements, Essential Fatty Acids, mitochondrial support, detox support, PCOS support, and natural stress and sleep aids. Our goal is to provide the best quality, tested, raw materials. Whenever possible we grow our own plant-based ingredients and any raw material we do not produce ourselves is subjected to the highest level of scrutiny to ensure the quality and purity.

Biogena

Booth #1054

8383 Wilshire Blvd., Beverly Hills, California, 90211 | USA

Ph: (213) 444-7902

Email: service@biogena-usa.com www.biogena-usa.com

Biogena is a family-owned business that specializes in highly professional and meticulous research, development, and production of hypoallergenic dietary supplements. Good Health is our mission and science is our passion. Our extensive specialist knowledge, our sense of responsibility and, above all, our uncompromising commitment to quality are the cornerstones of our mission to promote better health throughout the world. Biogena products, with their broad spectrum of application and use, provide the basis for this mission.

Biohm Clinical

Booth

#5092

425 Literary Rd. Ste 100, Cleveland, Ohio, 44113 | USA

Ph: (855) 750-0424

Email: support@biohmhealth.com www.biohmclinical.com

BIOHM Health, LLC, is a cutting-edge nutraceutical company that is committed to superior quality ingredients & efficacy. We develop & offer a unique line of products that are based on the latest scientific research of Dr. Mahmoud Ghannoum. Through its unique microbiome data analysis system and clinical trial validation program, BIOHM is using a higher level of evidence standards for dietary supplements. At BIOHM Health, LLC, we look forward to partnering with you to improve client outcomes.

Bionox ®

Booth #5044

220 N. Main Street, Suite #500, Greenville, South Carolina, 29601 | USA

Ph: (877) 278-9070

Email: customercare@bionoxusa.com www.bionoxusa.com

Bionox® is motivating wellness for all to live life fully with our trusted, scientifically tested and doctorformulated nitric oxide products. In 2005, Dr. Jay Wilkins discovered the clinically proven effectiveness of nitric oxide to maximize health. He founded Bionox® to develop and promote a diverse line of easy to digest supplements that motivate wellness across all lifestyles.

Bionox® offers solutions for competitive athletes, weekend warriors to those with chronic conditions seeking natural alternative wellness solutions.

BioProtein Technology

Booth #6098

5706 Benjamin Center Dr.,Ste. 114 Tampa, Florida, 33634 | USA

Ph: (800) 280-2456

Email: info@bioproteintech.com www.bioproteintech.com

BioProtein Technology is the home of BioPro+, the first of its kind Bioidentical alternative to synthetic HGH - Growth Hormone treatments. Since 2009 BioProtein Technology has been providing physicians and their patients cutting edge alternatives to the industry’s most common pharmaceutical anti-aging and regenerative drugs. Whether its hormones, weight loss, libido, or sleep & stress, BioProtein Technology has a non-synthetic alternative that works faster, is easier to use, and 100% safe.

Bio-Tech-Pharmacal.com

Booth #7102

3481 N. Hwy. 112, Fayetteville, Arkansas, 72704 | USA

Ph: (888) 906-4604

Email: info@bio-tech-pharm.com www.biotechpharmacal.com

Purity. Potency. Quality. Those three words created the foundation for Bio-Tech Pharmacal 35 years ago and remain our guiding light today. Bio-Tech supports health worldwide by producing pure, clean, high-quality nutraceuticals to strict cGMP guidelines. Our pursuit of excellence has led 100+ research institutions to rely on our products when they need pharmaceuticalgrade nutraceuticals for medical research and studies. Our highly bioavailable products are void of dyes, talc, binders, artificial colors, and synthetic flavors.

Biotics Research Booth #

1015

6801 Biotics Research Drive, Rosenberg, Texas, 77471 | USA

Ph: (800) 231-5777

Email: biotics@bioticsresearch.com www.bioticsresearch.com

Biotics Research Corporation was formed in 1975 and from day one the foundation has been “Innovation and Quality.” Our goals remain unchanged - innovative ideas, carefully researched concepts, and product development with advanced analytical and manufacturing techniques to develop and produce nutritional products of superior quality and effectiveness available exclusively to healthcare professionals. 1-800-231-5777 www.bioticsresearch.com

Body Logic MD

Booth #1016

4850 T Rex Ave, Boca Raton, Florida, 33431 | USA

Ph: (561) 452-8544

Email: dastern@bodylogicmd.com www.BodyLogicMD.Com

Founded in 2003, BodyLogicMD continues to grow! We are one of the nation’s largest networks of highly-trained practitioners specializing in integrative medicine, bioidentical hormone replacement therapy, and supplements. BodyLogicMD is a turn-key solution for practitioners who are looking to maximize their practice revenue and personal time, while gaining clinical support from a network of practitioners with diverse board certifications and specializations.

Boston Heart Diagnostics

Booth #5098

200 Crossing Blvd, Framingham, Massachusetts, 1702 | USA

Ph: (877) 425-1252

Email: customercare@bostonheartdx.com www.bostonheartdiagnostics.com

Boston Heart Diagnostics is transforming the treatment of cardiovascular and related diseases through novel clinical diagnostics, therapeutically focused reports, and personalized, scientifically designed nutrition and lifestyle programs that have the power to change the way healthcare providers and patients communicate about heart health.

BrainMaster Technologies, Inc.

Booth #2065

195 Willis St., Bedford, Ohio, 44146 | USA

Ph: (440) 232-6000

Email: sales@brainm.com www.brainmaster.com

BrainMaster offers the most cutting edge and comprehensive variety of Clinical EEG, 3D Brain Imaging, qEEG and Neurofeedback on the market. Application areas include real-time imaging utilizing sLORETA as well as the newly released xLORETA, normative databases and pre/post therapeutic comparison. Clinical and personal database driven Neurofeedback, biofeedback, peak-performance, research, VR and brain-controlled systems. Partner with us, and help us change lives, one brain at a time!

BrainTap

Booth #5071

2861 Trent Rd., New Bern, North Carolina, 28562 | USA

Ph: (914) 329-9152

Email: sales@braintap.com www.braintap.com

BrainTap, the Brain Fitness Company, provides a mobile app and optional headset that strengthens your brain. Our scientifically proven products are effortless to use and provide significant benefits in just 15 minutes. . Our friendly technology empowers you to think, sleep, and perform better, improving every area of your life, including the ability to better handle life’s stress. With over 1800 unique audio sessions, we created BrainTap to address the most important focused life outcomes.

Brite Booth #8060

1058 N. Tamiami Trail,Suite 108 Sarasota, Florida, 34236 | USA

Ph: (941) 284-5579

Email: jr@menopausemethod.com www.brite.live

We support women and men by providing hormones in an organic, solvent-free base.

Brooksville Pharmaceuticals Booth #2062

16410 Flight Path Dr., Brooksville, Florida, 34604 | USA

Ph: (352) 848-3466

Email: admin@brooksvillerx.com www.brooksvillerx.com

Brooksville Pharmaceuticals is an independent pharmacy located in Brooksville, Florida. We are dedicated to providing friendly, outstanding, personalized service to all of our customers.

Brooksville Pharmaceuticals is privately owned and operated by pharmacists. Our team has extensive experience in our current product offering and in the retail side of our business. As a result of this, we have established a great name for ourselves and take great pride in providing extra special service and individualized attention to our customers.

BTI Biotechnology Institute

Booth #4078

Jacinto Quincoces 39, Vitoria-Gasteiz, Pais Vasco, ES5801007 | Spain

Ph: 945160652

Email: pheredia@bti-health.com www.bti-biotechnologyinstitute.com/en/

BTI Biotechnology Institute was founded in 1999 by Dr. Eduardo Anitua, current President and Scientific Director of the company and today it is one of the leading companies in implantology and oral rehabilitation, as well as an international scientific benchmark in the application of regenerative therapies in different areas of medicine, from the field of oral surgery to specialties such as traumatology, dermatology, ophthalmology, sports medicine, cardiovascular, plastic and aesthetic surgery, among others.

Calmoseptine, Inc.

Booth #6090

16602 Burke Lane, Huntington Beach, California, 92647 | USA

Ph: (714) 840-3405

Email: kim@calmoseptine.com www.calmoseptine.com

Calmoseptine Inc. markets Calmoseptine Ointment in all 50 states, Canada, United Arab Emirates, Jordan, Cuba, Peru, and Chili. Calmoseptine Ointment is an effective, multi-purpose moisture barrier that protects and helps heal skin irritations. Calmoseptine Ointment is available in 2.5-oz jars or tubes, 4-oz tubes, 1/8-oz packets, and 20g tubes through most wholesalers, distributors and pharmacies. For more information, please call us at 800-800-3405, e-mail us at info@ calmoseptine.com, or visit www.calmoseptine.com.

Calroy Health Sciences

Booth #4026

14362 N Frank Lloyd Wright,Suite 1000 Scottsdale, Arizona, 85260 | USA

Ph: (800) 609-6409

Email: support@calroy.com www.calroy.com

Advancing Science. Enhancing Health. At Calroy, we translate breakthrough science into products without parallel. Through rigorous research and formulation, we develop transformative new solutions for health. Our team leads emerging scientific research, applies expertise on world-class natural ingredients, and then conducts formulationspecific research to optimize outcomes. The result is a highly focused approach, including the only dietary supplement patented to regress vulnerable plaque - Arterosil HP - and a revolutionary, longlasting nitric oxide supplement - Vascanox HP.

Canada RNA Biochemical Inc.

Booth #4048

4400 Hazelbridge Way,Unit 680 Richmond, British Columbia, V6X 3R8 | Canada

Ph: (604) 273-2233

Email: info@canadarna.com www.CanadaRNA.com

We specialize in niche natural medicine for practitioners: 1. Boluoke™ (lumbrokinase), the most potent and best researched oral fibrinolytic agent hands-down; 2. CordImmune™ (Cordyceps sinensis), the only Cordyceps on the market that tests for and declares its cordycepin content; and 3. Corio-PSP™ (Coriolus versicolor), the best researched mushroom for immune support in oncology. Remember to stop by our booth for a FREE coagulation health check ($95 value). Only 30 spots available.

Candela

Medical

Booth #8074

251 Locke Dr, Marlborough, Massachusetts, 1752 | USA

Ph: (508) 769-3453

Email: jonnap@candelamedical.com www.candelamedical.com/na

Candela is a leading global energy-based, device company with a comprehensive product portfolio and global distribution footprint in over 100 countries. With hundreds of patents issued, we’re dedicated to the development of innovative products that allow treatment providers to offer advanced solutions for a broad range of medical aesthetic applications.

Canfield Scientific, Inc.

Booth #6048

4 Wood Hollow Road, Parsippany, New Jersey, 7054 | USA

Ph: (973) 434-1200

Email: info@canfieldsci.com

Canfield Scientific is the global leader in developing and distributing imaging systems for the medical and skin care industries. Used in hospitals, medical and aesthetic practices, medical spas, and skin and wellness centers, Canfield’s advanced photographic imaging solutions are an integral part of consultations. Today thousands of surgical and non-surgical consultations begin with images being captured by Canfield’s powerful imaging tools that improve communications, align doctor-patient expectations, facilitate treatment planning, and highlight results.

Carbon-60, Greska’s

Booth #8070

8156 S. Wadsworth Blvd., Littleton, Colorado, 80128 | USA

Ph: (720) 600-6040

Email: bob@c-60.com www.C-60.com

Greska’s Carbon-60 is the world’s largest supplier of the ONLY proven food-grade carbon 60 product. It is a nano sized pure carbon-based cellular detoxifier, Free Radical stabilizer and more. It helps reduce a number of health issues either applied topically or taken as an orally as a dietary supplement. It is a powerful antioxidant and helps reduce inflammation. Stop by Booth 8070 for a FREE SAMPLE. You’ll be glad you did.

CAREstream America

Booth

#7047

200 Technology Park,Suite 1040

Lake Mary, Florida, 32701 | USA

Ph: (855) 892-3872

Email: aeiger@carestreamamerica.com www.carestreamamerica.com

CAREstream America has cutting-edge aesthetic solutions. Our innovative Pro-Nox is a 50/50 Nitrous Oxide/Oxygen analgesic relief of procedure pain and anxiety without opioids. Our body-jet line features the Evo and Eco for micronized fat harvesting and gentle body contouring. We also offer a comprehensive regenerative therapy selection that includes ALPHA2ACTIVE, CAREprp, the Marrow Marxman, the Slimspec by Medispec, and the VeinViewer Flex. Visit our website to view our complete portfolio of aesthetic and regenerative solutions.

Carie Boyd Pharmaceutical Compounding Booth #6079

8400 Esters Blvd.,Ste. 190 Irving, Texas, 75063 | USA

Ph: (817) 282-9376

Email: vrados@carieboyd.com www.carieboyd.com

Carie Boyd is a state-of-the-art, wellness-focused compounder. We provide clinics, hospitals, provider networks, and the patients they serve with the highest-quality compounded medications. With an industry leading 1.5% potency variance (6x better than regulatory requirements), we are one of the nation’s leading compounders of hormone pellets. We also have other wellness products in categories such as weight loss, anti-aging, hair loss prevention, sexual health, and IV infusions.

Castle Connolly Private Health Partners, LLC

Booth #3080

530 7th Ave.,,Suite 2401

New York, New York, 10018 | USA

Ph: (212) 367-1950

Email: info@ccphp.net www.ccphp.net

Castle Connolly Private Health Partners works to empower and protect the physician-patient relationship through a concierge medicine model, helping physicians practice the way they intended, and patients to receive the care they deserve.

Cell Surgical Network

Booth #1037

Suite 301, Palm Desert, California, 92211 | USA

Ph: (760) 424-8263

Email: sean@cellsurgicalnetwork.com www.cellsurgicalnetwork.com

Cell Surgical Network provides physicians technology that automatically isolates their patients’ adipose derived stem cells for regenerative purposes. CSN prevailed in a landmark federal court case against the FDA, allowing their use of personal stem cells isolated from adipose (fat) tissue. This ruling will allow doctors to continue the practice of medicine and provide potentially healing stem cells to their patients, while systematically collecting outcome data along with CSN’s over 500 international physicians.

Cellcore Biosciences

Booth #6103

3750 E Pewter Falls St,Suite, 100 Meridian, Idaho, 83642 | USA

Ph: (208) 296-6506

Email: events@cellcore.com www.cellcore.com

“Redefining health with root cause solutions. CellCore Biosciences promotes the body’s natural ability to detox through the utilization of Carbon Technology. We are dedicated to providing you with the products, support, and education to help you understand how to approach root cause solutions in a whole new way.”

Central Drugs Compounding Pharmacy

Booth #6013

520 W. La Habra Blvd., La Habra, California, 90631 | USA

Ph: (562) 691-6754

Email: clinicalrph@centraldrugsrx.com www.centraldrugsrx.com

Central Drugs is an industry leader in the art and science of custom compounding and individualized health-care solutions with a team of expert pharmacists at our state-of-the-art 503A compounding pharmacy. Central Drugs is your pharmacy partner, working with clinics to provide resources, education, and services to improve the overall health of your patients. Central Drugs specializes in compounding, seeking the most innovative, effective and trending formulations to meet the needs of clinics across 30 states.

Cerbo EHR

Booth #2043

350 SE Mill St.,Ste.11 Portland, Oregon, 97214 | USA

Ph: (541) 391-4600

Email: sales@cer.bo www.cer.bo/explore-the-demo

Cerbo is simply the best EHR + Patient Portal for functional medicine. Scheduling includes online requests, custom reminders, and native telehealth. Charting is ultra-flexible, with eRx and supplements, inventory, IVs, injections, pelleting, and your custom recommendations, plus powerful templating tools. Integrated merchant services include credit/ ACH, subscriptions, and payment plans. And your Patient Portal with custom patient forms is styled to match your website. And lots more! All with incredible configuration & support. Demo: cer.bo/explore-the-demo/

Chi’s Enterprises Inc.

Booth #5042

1435 N. Brasher St., Anaheim, California, 92807 | USA

Ph: (714) 777-1542

Email: wchi29@yahoo.com www.chi-health.com

Chi’s Enterprise offers supplements including MYOMIN, aromatase reducer. Jonathan Wright, MD and other doctors recommend Myomin to reduce estradiol/estrone, increase testosterone for men/women including BHRT users. Research Genetic Cancer Center (RGCC) highly recommend ANGIOSTOP for inhibiting angiogenesis factors, inhibiting signal transduction pathways, inducing caspases for apoptosis. VEINLITE- CVD, reduces D-Dimer. OXYPOWER- hypoxia, excellent for lung, heart, energy. With BAMBOOEXTRACT, excellent for COVID-19. LIVER CHI induce interferon for hepatitis. KIDNEYCHI for UTI and prevent sexual disease.

ChromaDex, Inc.

Booth #6036

10900 Wilshire Blvd.,Suite 600 Los Angeles, California, 90024 | USA

Ph: (908) 625-4793

Email: greg.arabatzis@chromadex.com www.Pro.truniagen.com

Your NAD+ supply declines with age as well as in response to stressors on your body including alcohol consumption, intense exercise, and lack of sleep. While nicotinamide riboside can be found naturally in certain foods, you cannot get anywhere near the amount you need through a normal diet to effectively increase NAD+. That is why we created Tru Niagen®, the only patented, broadly studied, and safety-reviewed nicotinamide riboside in the world.

Clarke Bioscience

Booth #9051

17448 Highway 3,Ste. 140 Webster, Texas, 77598 | USA

Ph: (281) 217-0092

Email: chris@clarkebioscience.com www.clarkebioscience.com

Clarke Bioscience focuses on manufacturing specialized nutraceutical compounds to support overall health and wellbeing, including brain, bone, and immune health. With neuroscientist Dr. Lewis Clarke as the founder, Clarke Bioscience uses the same protocols Dr. Clarke has been using in hospital and clinical settings for decades. We emphasize a biochemical-based approach to health maintenance, completely backed by a strong foundation of cutting-edge scientific research and evidence.

Cleerly, Inc.

Booth #4070

110 16th St. Ste 1400 # 104, Denver, Colorado, 80202 | USA

Ph: (617) 735-0550

Email: ashley.boyd@cleerlyhealth.com www.cleerlyhealth.com

Cleerly is a digital healthcare company transforming the way clinicians approach the treatment of heart disease. We design intelligent clinical technologies to help clinicians precisely identify and define atherosclerosis earlier, so they can provide personalized, life-saving treatment plans for all patients throughout their care continuum. Our AI-driven digital care platform offers simpler, faster, more accurate heart disease diagnostics and reporting that’s tailored to each stakeholder, improving overall clinician and financial outcomes.

Clinical Resolution Lab., Inc.

Booth #5039

1530 Moonstone, Brea, California, 92821 | USA

Ph: (213) 384-0500

Email: info@clinicalresolution.com www.skincarecrl.com

Clinical Resolution Laboratory, Inc. is a US medical device manufacturer and full-service product development laboratory serving wholesalers & skincare professionals. Our product line includes microneedling devices (InnoPen & MTS Rollers), serums, & masks all manufactured in the USA.

Clinicians Supplement

Consultants

Booth #8015

180 Froehlich Farm Blvd., Woodbury, New York, 11797 | USA

Ph: (855) 272-7220

Email: dlc@cscprivatelabel.com www.cscprivatelabel.com

Clinicians Supplement Consultants allows practitioners to provide concierge service and sales of professional supplement brands and practitioners own private label supplements to their patients. CSC has an exclusive professional only brand, a concierge supplement fulfillment service, a private label development and management program. CSC allows practitioners focus on the patient while CSC handles all aspects of inventory, dispensing, fulfillment, and patient compliance. CSC handles the supplement business allowing practitioners to focus on their patients.

College Pharmacy

Booth #6038

3505 Austin Bluffs Pkwy,Ste.101

Colorado Springs, Colorado, 80918 | USA

Ph: 800-888-9358 x171

Email: sky@collegepharmacy.com www.collegepharmacy.com

THE COLLEGE PHARMACY DIFFERENCE: QUALITY. INNOVATION. EXPERIENCE. SINCE 1974. For over 40 years, College Pharmacy has provided healthcare practitioners and patients with high-quality compounded preparations and outstanding customer service. Our experienced pharmacists collaborate with patients and healthcare practitioners to provide innovative solutions for health and wellness success. It is our compounding process, attention to detail, and quality of the compounding components that continues to make our formulations exceptional.

PHARMACY

Compound Connection

Booth #7067

5 Cowboys Way,Suite 300

Frisco, Texas, 75034 | USA

Ph: (469) 214-0786

Email: rhettrichardson@ht-ca.com www.compoundconnection.com

Compound Connection is a web-based purchasing solution for medical professionals. The Compound Connection network connects you to compounded pharmacy products and supplies at a discounted price by leveraging the network’s purchasing power compared to going directly to the pharmacy.

CosmoFrance Booth #4098

2121 SW 3rd Avenue,Ste. 200 Miami, Florida, 33129 | USA

Ph: (305) 538-0110

Email: office@cosmofrance.net www.cosmofrance.net

__CosmoFrance Inc. - established in 1997 in Miami, FL - specializes in the import & distribution of medical devices for non-invasive aesthetic procedures. CosmoFrance manufactures & distributes the following products in the US: • ezPRF® Platelet-Rich Fibrin, the ultimate blood concentrate • ezGEL®, the 100% Natural biostimulating gel. • The DermaSculpt® blunt-tipped microcannula. • The CosmoPen® microneedling pen. • NovaThreads® absorbable US-made PDO threads. Visit cosmofrance.net__

CRE8 Pharmacy

Booth #4042

3700 NW 126th Avenue, Coral Springs, Florida, 33065 | USA

Ph: (888) 224-5181

Email: david@cre8rx.com www.cre8pharmacy.com

CRE8 Pharmacy offers compounding services for personalized medicine and patient-specific prescriptions. We are a team, working at creating perfect formulations, dispensing orders reliably and resolving any issues promptly. Specializing in Peptides, Hormone Replacement Therapy, Sexual Wellness, Weight Loss & Energy, Cognitive & Mental Health formulas. Sterile & Non-Sterile compounds, Generic & Brand medications. Welcome to the future of compounding pharmacy.

CuraMedix

Booth #1056

40 Albion Rd., Ste.103, Lincoln, Rhode Island, 2865 | USA

Ph: (401) 333-6500

Email: info@curamedix.com www.curamedix.com

CuraMedix is focused on regenerative medicine and is the US distributor of STORZ Medical EPAT devices. Extracorporeal Pulse Activation Technology (EPAT), sometimes referred to as ESWT or shockwave, is an evidence-based, non-invasive approach to treating musculoskeletal pain. Highlighted products include the OrthoPulse Ultra 100, DuoLith T-Top Ultra, and DuoLith RPW/FSW Modular.

Cyrex Laboratories

Booth #3032

2602 S. 24th Street, Phoenix, Arizona, 85034 | USA

Ph: (602) 759-1245

Email: michelle.c@cyrexlabs.com www.JoinCyrex.com

Cyrex Laboratories® is a unique clinical immunology laboratory specializing in environmentally-induced autoimmunity. Cyrex delivers next generation assessments for antigenic intestinal and blood-brain barrier permeability – gateways to autoimmunity; environmental trigger screening including dietary antigens, pathogens and xenobiotics; and multitissue antibody testing for predictive biomarkers of autoimmune reactivity. Through continuous collaboration with leading experts in medical research and clinical practice, Cyrex develops innovative assays that assess the cross-connections between the body’s immune, gastrointestinal and neurological systems.

Cytox LLC

Booth #7044

40 Hampshire Road, Mahwah, New Jersey, 7430 | USA

Ph: (551) 427-5143

Email: alzheimers@vanguardpharma.com www.cytoxgroup.com

Cytox provides non-invasive, risk assessment and patient stratification tools for Alzheimer’s disease and dementia. It’s primary technology is genoSCORE(TM) a genetic test to predict future risk of cognitive decline due to Alzheimer’s disease (AD). The test, which uses a simple blood or saliva sample, analyzes patient genotypes against an array of over 100,000 single nucleotide polymorphisms (SNPs) associated with AD. The test is available in the US as the Sampled Alzheimer’s Risk Test.

Daiwa By U.S Jaclean, Inc.

Booth #7085

1816 W. 135th St.

Gardena, California 90249 | USA

Ph: (800) 5241-2221

Email: sales@usjaclean.com www.daiwamassage.com

Established in 1982 & Headquartered in Gardena, CA. We offer an assortment of high-quality health & wellness products. We pride ourselves with great costumer service.

Darmerica

Booth #3047

198 Wilshire Blvd., Casselberry, Florida, 32707 | USA

Ph: (407) 766-9092

Email: khamza@darmerica.com www.Darmerica.com

Darmerica is a Florida based, FDA Inspected, GMP Compliant, and State Licensed distributor of API’s, Nutraceuticals, Peptides, and other bulk chemicals for the Pharmaceutical and Compounding Pharmacy Industries. Darmerica is licensed to ship nationwide, and is also an FDA Inspected and state licensed relabeling and repacking facility.

DaVinci Laboratories Booth #4084

929 Harvest Lane, Williston, Vermont, 5495 | USA

Ph: (802) 872-1924

Email: bkanya@foodsciencecorp.com www.davincilabs.com

Our focus is on improving lives by producing quality doctor formulated supplements derived from real nutrients—create supplements that make a difference and take standards to a higher level. Within every DaVinci product, you can trust that you will always receive the very best.

Designer Drugs Pharmacy

Booth

#4092

7304 Jarnigan Rd., Chattanooga, Tennessee, 37421 | USA

Ph: (423) 954-2585

Email: form-submission@squarespace.info www.designerdrugs.us

For more than 20 years, Designer Drugs has been working with patients and physicians to provide custom solutions for their pharmaceutical needs. Our technicians are certified to compound sterile and non-sterile medications. Our pharmacy proudly compounds ophthalmics, injections, dermatologic preparations, hormone replacement options, and many more products. These preparations are designed specifically to meet individual needs with the highest level of safety and accuracy. Designer Drugs is licensed to ship prescriptions to all fifty states.

Designs for Health

Booth #2021

980 South Street, Suffield, Connecticut, 6078 | USA

Ph: (860) 752-7474

Email: jkopacka@designsforhealth.com www.designsforhealth.com

Our Mission: Designing a Well World. We are driven by a higher purpose. We are activists for health - rooted in and united by science. Transforming boundaries, breaking barriers, setting new standards, disrupting the status quo. We believe in science-based nutrition and natural medicine, developing health products without compromise, and advancing the way education and technology support wellness for all. We design a new paradigm. We design a well world

DEXA+ Booth #6093

141 Peyerk Ct. Unit D, Romeo, Michigan, 48065 | USA

Ph: (586) 532-1150

Email: torlando@dexaplus.com www.dexaplus.com

DEXA+ is a provider DEXA Scanners and an educator of the benefits of DEXA and the 3 Critical Health Markers (Bone Health, Body Composition and Visceral Fat, the number predictor of heart disease and Type 2 Diabetes.) Our Scanners and Programs provide State of the Art equipment and leading technology for clinics. If you would like to include DEXA in your clinic DEXA+ is the leader in the industry. Contact us to learn more.

Diagnostic Solutions Lab

Booth #1021

31 Lupi Court,Ste 250

Palm Coast, Florida, 32137 | USA

Ph: 877-485-5336 x 8010

Email: Heather.Whitt@diagnosticsolutionslab. com www.diagnosticsolutionslab.com

Diagnostic Solutions Laboratory bridges the gap between healthcare providers and the clinical laboratory by offering cutting-edge laboratory tests such as GI-MAP, OMX (Organic Metabolomics), CytoDX, and GenomicInsight. Designed to identify underlying root causes of symptoms and disease, our test results give practitioners the tools needed to formulate personalized treatment protocols for optimized patient outcomes. Our commitment to education and service ensures both practitioners and their patients will benefit from the latest research.

Doctor Multimedia

Booth #3042

8070 La Jolla Shores Dr. #528, La Jolla, California, 92037 | USA

Ph: (800) 679-3309

Email: info@doctormultimedia.com www.doctormultimedia.com

We’re a team of energetic, young professionals. We’re successful for one simple reason: no one can outwork us. We’re open 24 hours a day, 7 days a week, 365 days a year. We do it out of passion, and because that’s when our clients need help. We have graphic designers, WordPress developers, social media masters, content creators, SEO wizards, IT problem solvers, and marketing gurus, ready to help your medical practice thrive.

Doctor’s Data, Inc.

Booth #7021

3755 Illinois Ave., St. Charles, Illinois, 60174 | USA

Ph: (630) 377-8139

Email: breynold@DoctorsData.com www.doctorsdata.com

Doctor’s Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced, CLIA-licensed clinical laboratory since 1972. A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, hormone status, cardiovascular risk, liver and metabolic abnormalities, and more.

Water®

Double Helix Water

Booth #8094

251 NW 1051 Rd., Holden, Missouri, 64040 | USA

Ph: (800) 928-6883

Email: info@doublehelixwater.com www.doublehelixwater.com

Double Helix Water is a unique,, ultra pure water from containing concentrated Stable Water Clusters formed at a microscopic level. Double Helix Water, in conjunction with proper nutrition, may help lay the groundwork for healthy cells and allow the body to heal itself naturally, maintain wellness, and restore vitality. Go Beyond Hydration with Double Helix Water.

Dp Derm

Booth #2047

11900 Biscayne Blvd,,Ste.252 North Miami, Florida, 33181 | USA

Ph: (305) 552-0550

Email: joel@dpderm.com www.dpderm.com

Here at Dp Derm our mission is to guide practitioners in providing the best possible treatments for their clients, whilst supporting them with proven protocol-based products that work.nThe Dp Dermaceuticals range from Dermapenworld is the world’s first Meso-Infusion skin care range and are Non-Negotiables during skin needling. The active Meso-Glide combinations have proven protocol outcomes that are endorsed by thousands of practitioners around the globe, for safe, effective treatments without ANY side effects.

Drtalks.com

Booth #3043

7040 Avenida Encinas,,Ste. 104-284 Carlsbad, California, 92011 | USA

Ph: (619) 436-7750

Email: bret@drtalks.com www.drtalks.com

Drtalks brings together some of the most soughtafter leaders on the front lines of health, wellness, and medicine. Drtalks delivers on-demand access to talks, summits, and more straight from the experts.

Drucker Labs

Booth #

1600 Capital Ave. Suite 100

Plano, Texas, 75074

Ph: (972) 526-5149

Email: lsanders@druckerlabs.com www.driclerlabs.com

Drucker Labs has dedicated the last 24 years to innovating, developing and manufacturing a complete line of superior liquid dietary supplements for Optimal Immune Function. Our proprietary intraLINE 2.0 products are a key foundation for immunological support and resistance. intraMAX® 2.0, intraKID® 2.0 and intraMIN® are the highest quality, 100% Organically-bound trace mineral-based nutritional supplements on the market – created from the finest and purest ingredients obtainable.

,Ste. 301C | USA

EB Supplements

Booth #2095

299 Montview, Rosemere, Quebec, J7A2W2 | Canada

Ph: (514) 862-8599

Email: marcvaugeois@gmail.com www.h5hg.com

Precision Analytical created the DUTCH Test (dried urine test for comprehensive hormones) to help providers solve complex patient cases. DUTCH is a group of validated tests that provide a complete evaluation of sex and adrenal hormones, including metabolites._The simple and convenient at-home collection for patients, and clinical support on every DUTCH report, puts you in the driver’s seat—allowing you to solve your patients’ most complex hormone issues.

EB Supplements is a research-driven dietary supplement brand backed by industry leaders who have been formulating, researching, and manufacturing nutritional supplements for best-in-class health and nutrition brands for over 20 years. Our mission is to provide a novel approach to healthy aging using cutting-edge, clinically proven, patented ingredients and nutrient delivery technologies.

EB Supplements products feature MAG-O3™ monoglyceride fish oils, which have a 5-star IFOS rating and adhere to the highest quality standards.

electroCore, Inc.

Booth #3033

205 Forge Way,Suite 205 Rockaway, New Jersey, 7866 | USA

Ph: (888) 903-2673

Email: gabi.dennis@electrocre.com www.gammaCore.com

electroCore, Inc. is a commercial stage bioelectronic medicine company dedicated to improving patient outcomes through its non-invasive vagus nerve stimulation therapy. gammaCore (nVNS) is the first non-invasive, hand-held device applied at the neck to treat migraine and cluster headache through the utilization of a mild electrical stimulation to the vagus nerve. Designed as a portable, easy-to-use technology, gammaCore can be self-administered by patients, as needed, without the potential side effects associated with commonly prescribed drugs.

Eleve Health

Booth #4099

2400 Main St. Ste 200, Irvine, California, 92614 | USA

Ph: (888) 537-7087

Email: dhilliard@elevehealth.com www.elevehealth.com

Eleve Health is a leader in the Health & Wellness field, and is a unique brand that represents Wellness, Social-Media, Sports, and Pop Culture. Their products include; Pulsed Electromagnetic Field Therapy (PEMF), Vibro-Acoustic Therapy, and Low-Level Light Therapy. Passionate and committed to educating and bringing awareness about innovative health solutions and their benefits to the masses. They aim to inspire people to elevate their game, elevate their health, elevate their mind & elevate their life!

Empower Pharmacy

Booth #4079

7601 N Sam Houston Pkwy W, Houston, Texas, 77064 | USA

Ph: (281) 638-0934

Email: crosenauer@empowerpharmacy.com www.empowerpharmacy.com

Empower is both a PCAB®-accredited 503A compounding pharmacy and an FDA-registered 503B outsourcing facility serving millions of patients and providers across the United States. We manufacture sterile and nonsterile medications — both for patient-specific prescriptions and for office use — that are not available through commercial manufacturers or may require customization by a prescriber. Our extensive drug catalog and ability to accommodate any dosage form allows us to meet our clients’ custom pharmaceuticals needs.

Enbiosis Biotechnology

Booth #2099

One Broadway 14th Floor, Cambridge, Massachusetts, 2142 | USA

Ph: (617) 386-3219

Email: ozkan@enbiosis.com www.enbiosis.com

ENBIOSIS produces AI-driven next-generation biotechnology solutions aimed to improve human health and quality of life by using microbial organisms to form a symbiotic life with the human body. Our precision medicine activity includes gut microbiome analysis, personalized nutrition and diet technologies, next-generation probiotics, and biotherapeutics.

EPI / Alpha-Stim

Booth #3074

2201 Garrett Morris Pkwy, Mineral Wells, Texas, 76067 | USA

Ph: (940) 328-0788

Email: amanda@epii.com www.alpha-stim.com

Alpha-Stim is an FDA cleared, handheld medical device that has been proven time and again to effectively treat anxiety, insomnia, depression, and pain. AlphaStim uses cranial electrotherapy stimulation (CES), delivered through a patented waveform via two earclip electrodes, along with microcurrent electrical therapy (MET) to treat pain at the source via two handheld Smart Probes. Unlike medications, AlphaStim has no risk of addiction or lasting side effects.

Epionce

Booth #7066

10211 W. Emerald Street, Boise, Idaho, 83704 | USA

Ph: (866) 374-6623

Email: info@epionce.com www.epionce.com

Dermatologist-developed and clinically proven, Epionce is a physician-strength skin care line rooted in hard science and integrates over 20 years of clinical skin research. Formulated with antioxidant-rich botanical blends and barrierboosting ceramides, Epionce optimizes the health of the skin by working with its own protective and reparative systems. Over 15 independent trials have proven the multitasking products are safe and effective in helping to reverse and prevent visible skin aging and symptoms of skin disease.

®

Epoch Lasers, LLC

Booth #1033

5233 Male Springs Dr., Chagrin Falls, Ohio, 44022 | USA

Ph: (440) 785-2298

Email: info@epochlasers.com www.epochlasers.com

Designed by a team of engineers and therapists in the US, Epoch® Lasers offers The epoch-980, a high powered therapeutic laser, and The InfraHelios, a home pain management system, for treating patients experiencing pain for a variety of reasons. Epoch® Lasers’ Therapy systems initiate healing at the cellular level. This enables the reduction of compounds related to pain and inflammation while simultaneously accelerating the healing process and tissue regeneration, all non-invasively.

Ergo-Flex Technologies

Booth #8086

13622 Poplar Circle Ste 403, Conroe, Texas, 77304 | USA

Ph: (936) 588-5510

Email: sales@ergoflextechnologies.com www.ergoflextechnologies.com

Ergo-Flex Technologies, LLC. is the developer, manufacturer, and distributor of innovative equipment for chiropractic and therapeutic healthcare professionals that provide extraordinary results for patients experiencing chronic pain. The TOTAL BRAIN & BODY O2™ is designed to facilitate healing by super-saturating nearly all body tissues (especially brain, kidney, liver) plasma and lymph with very high levels of oxygen that permeates the tissues because of the exercise component.

EVEXIAS Health Solutions

Booth #4055

920 S. Kimball Ave.,Suite 100 Southlake, Texas, 76092 | USA

Ph: (833) 839-4735

Email: info@evexias.com www.evexias.com

EVEXIAS Health Solutions (EHS) has helped thousands of practitioners enhance patient care through advanced medical education and training from industry-leading experts and cutting-edge therapies and technologies that support disease prevention and improve quality of life. Every EHS program is backed by strategic business plans exclusively developed to drive growth for private medical practices.

Evolutionary Biologics

Booth #7055

14 Penn Plaza 9th floor, New York, New York, 10122 | USA

Ph: (786) 396-9696

Email: www.evolutionarybiologics.com www.evolutionarybiologics.com

EVOSKIN

Booth #4074

6 Lincoln Knoll lane,Suite 100A Burlington, Massachusetts, 1803 | USA

Ph: (802) 386-7546

Email: info@evoskin.com www.evoskin.com

Evoskin sources high-end aesthetic medical devices from innovative companies around the world for U.S. medical providers, including plastic surgeons, cosmetic physicians, dermatologists, and medical spas. Our products are hand-selected directly by us for their quality, level of innovation, and ROI for medical providers. We are committed to provide the best customer service and warranties for our products.

ExocelBio

Booth #3070

3978 Sorrento Valley Blvd.,Ste.310 Doylestown, Pennsylvania, 18902 | USA

Ph: (858) 255-4499

Email: jillian.vogel@exocelbio.com www.exocelbio.com

ExocelBio is a state-of-the-art biotechnology company leveraging exosomes to advance the science of precision growth factors in pursuit of making aesthetics and anti-aging a reality. Designed as a companion product, our professional-use-only product is for skin and hair rejuvenation. Exovex, a line of aesthetic exosomes serums, can be used in postmicroneedling/energy-based aesthetic applications. The multipotent exosomes in Exovex help reduce the signs of aging by alleviating the stress of modern living and promoting healing for all skin and scalp types.

EZRA

AI Inc.

Booth #9029

419 Park Ave., S, Ste.600, New York, New York, 10016 | USA

Ph: (917) 804-5366

Email: jennifer.iuliano@ezra.com www.ezra.com

Ezra leverages the power of MRI to get a look inside your body while safely screening for more than 22 potential cancers and other diseases.

Fagron Genomics (fka GX Sciences)

Booth #3062

4150 Freidrich Lane,Ste. H Austin, Texas, 78744 | USA

Ph: (844) 258-5564

Email: info@gxsciences.com www.GXSciences.com

Fagron Genomics US (fka GX Sciences) is an advanced, certified laboratory based in Austin, TX that empowers providers with the most comprehensive Nutrigenomic (NGx) and Pharmacogenomic (PGx) interpretation platform available. Designed for medical professionals by medical professionals; our customized reporting platform validates patients’ specific nutritional needs, laboratory recommendations, lifestyle recommendations, health precautions, and more based on individual DNA findings. We offer customizable, easy-to-use, scientifically validated genetics reports to provide health and recovery through personalizing medicine.

Floré by Sun Genomics

Booth #2087

5151 Shoreham Place, Ste. 105, San Diego, California, 92122 | USA

Ph: (661) 888-4799

Email: Customerservice@sungenomics.com www.Flore.com

Floré provides truly custom formulated probiotics based on a Complete Gut Microflora Test. We analyze the trillions of microbes in your gut microflora and craft a unique formula for your unique gut health needs. Our formulas are designed so you only have to take one-pill-a-day. Floré personalized probiotics help with abdominal pain, constipation, bloating, SIBO, leaky gut, and other digestive issues. They are 100% natural, vegan (optional), gluten-free, non-GMO, and are formulated without artificial preservatives.

Evolutionary Biologics Inc

STOP BY OUR BOOTH, LET’S TALK ABOUT OUR OPINION

When it comes to regenerative medicine, compliance matters. Stop by our booth and let’s discuss our legal opinion letter issued by a former FDA compliance officer that supports our 361 status.

If you are searching for an HCT/P supplier that can demonstrate compliance with FDA regulation, look no further. Come take your place in this next chapter being written in Regenative Medicine.

Forum Health

Booth #7037

601 S. Saginaw St. 5th floor, Fling, Michigan, 48501 | USA

Ph: (331) 645-2310

Email: hsinarahua@forumhealth.com www.forumhealth.com

Forum Health is a growing network of healthcare providers & practices who serve patients around the world. Our providers have decades of experience practicing functional and integrative medicinedrawn from areas in clinical nutrition, anti-aging, environmental science, chronic disease, lifestyle medicine and more. Through practice acquisition and employing talented healthcare providers, we connect the best like-minded practitioners with business experts and a network of collaborative peers. Become part of our network today!

Fotona LLC

Booth #1027

4343 W Royal Ln,Suie 116 Irving, Texas, 75063 | USA

Ph: Humberto Campos

Email: hcampos@fotona.org www.fotona.com/us

With over 50 years of laser expertise and industry leadership, Fotona has sold over 30,000 lasers worldwide with distribution in over 60 countries. Fotona produces award-winning lasers in dentistry, aesthetics, dermatology, gynecology, and surgery. Having a strong history of dedication to R&D, Fotona has a reputation for unparalleled quality, reliability, ease-of-use and durability.

Fullscript

Booth #5013

9185 E Pima Ctr Pkwy,Suite 200 Scottsdale, Arizona, 852584646 | USA

Ph: (603) 724-4988

Email: gillian.magnusson@fullscript.com www.fullscript.com

Fullscript is a powerful, free integrative care delivery platform. It offers singular access to personalized treatment planning, ongoing wellness support and education, and healthcare’s best supplements. Practitioners craft virtual treatment plans, attaching resources and products that patients can access anywhere, any time. Fullscript also delivers active support with medically-reviewed resources, refill reminders, and other treatment adherence tools to simplify the path to optimal health.

GAINSWave®

Booth #7027

2920 NE 207th St.,9th Floor

Aventura, Florida, 33180 | USA

Ph: (305) 912-6677

Email: jeremy@gainswave.com www.gainswave.com

GAINSWave® and FemiWave® are high-demand procedures that enable any medical practice to quickly add $200k or more to their bottom line. GAINSWave® and FemiWave® membership provides medical practices a simple, turn-key solution to enter the highly profitable field of male and female sexual wellness. We’ve helped hundreds of doctors and health care professionals from all types of backgrounds, provide much-needed business solutions that are proven, increase practice cash revenues and assist in scalable business growth.

Gameday Men’s Health

Booth #7042

2753 Jefferson St., Ste.204, Carlsbad, California, 92008 | USA

Ph: (949) 542-9717

Email: evan@gamedayhealth.com www.gamedaymenshealth.com

We are the man cave for Men’s health and specialize in testosterone replacement therapy and ED

Genedix LLC

Booth #1038

601 7th St. S,Ste. 565 St. Petersburg, Florida, 33701 | USA

Ph: (727) 456-8968

Email: fp@genedix.com www.genedix.com

Genedix goal is to provide products that help people improve their quality of life using scientifically proven, natural products. We are excited to introduce the first ever facial mask of its kind, RevivaMask. This high-quality compressed mask sheet maximizes absorption of a high amount of Cellular Matrix. The mask consists of a powerhouse of UCT-MSC (umbilical cord derived) cytokines, and growth factors that can be used for post procedure care to enhance effectiveness and outcomes.

Genova

Booth #4021

63 Zillicoa St., Asheville, North Carolina, 28801 | USA

Ph: (828) 210-7362

Email: KVandenberg@gdx.net www.gdx.net

Genova Diagnostics is a leading clinical laboratory applying systems-based testing approaches to the diagnosis, treatment and prevention of complex chronic disease. Genova specializes in clinical laboratory services with actionable information.

Global Life Rejuvenation

Booth #4043

168 East Main Street, Denville, New Jersey, 7834 | USA

Ph: (973) 627-1750

Email: demetriaglaab@denvillemedical.com www.globalliferejuvenation.com

Global Life Rejuvenation A Leader in Anti-Aging Medicine and Hormone Replacement Therapy for Men and Women. Global Life Rejuvenation has Network Providers nationwide. Global Life educates and connects patients with our highly trained network physicians specializing in Anti -Aging Medicine.

GlycanAge Ltd. Booth #9033

The Catalycst; 3 Science Square,Office 4.31 Newcastle, England, NE4 5TG | United Kingdom

Ph: 4.48E+11

Email: zorrie@glycanage.com www.glycanage.com

Longevity was never this achievable. Measure your biological age with a simple at-home test that analyzes glycans. Those are complex sugars that give us an unprecedented look into the state of your lowgrade inflammation. Backed-up by: * 200+ research papers * Analysed 200K+ individuals. Our tests can tell you which of your lifestyle choices are helping you stay healthy and which you should change.

SCIENCE HAIR

GRAIL

Booth #7038

1525 O’Brien Drive, Menlo Park, California, 94025 | USA

Ph: (833) 694_2553

Email: customerservice@grailbio.com www.galleri.com

GRAIL is focused on saving lives and improving health by pioneering new technologies for early cancer detection. Their first product, the Galleri® multicancer early detection test, complements guidelinerecommended screenings, and can detect a cancer signal across more than 50 types of cancer through a routine blood draw for adults with elevated risk, such as aged 50 or older. When cancer is detected, the Galleri test can predict the cancer signal origin.

Great Plains Laboratory

Booth

#2063

11813 West 77th Street, Lenexa, Kansas, 66214 | USA

Ph: (913) 341-8949

Email: sales@gp-labs.com www.greatplainslaboratory.com

Great Plains Laboratory is a leader in providing testing for nutritional factors in chronic illnesses such as fibromyalgia, autism, AD(H)D, gastrointestinal and neuropsychiatric disorders. We offer a variety of metabolic tests including those for immune deficiency, amino acids, essential fatty acids, inflammation, metal toxicity, toxic chemicals, and food allergies.

Hair Science

Booth #9021

608 Point Vista Drive, Aledo, Texas, 76008 | USA

Ph: (866) 558-1744

Email: info@hairscience.com www.HairScience.com

Hair Science is a research and development company dedicated to advancing products that improve hair and scalp health. Our corporate compounding pharmacy is AnazaoHealth. Come visit our booth to learn about our prescription-based hair loss treatments, Formulas 82M, 82F, and 82D and our over-the-counter hair loss shampoo, Formula 82S.

DEVELOPERS OF ADVA NC ED HAIR LOSS FORMULAS

Hallandale Pharmacy

Booth #6055

2666 Sw 36th St, Ft. Lauderdale, Florida, 33312 | USA

Ph: (954) 455-3822

Email: jmaman@hallandalerx.com www.Hallandalerx.com

Hallandale Pharmacy’s is a 503a designated and PCAB accredited compounding pharmacy, that is committed to provide quality and affordable custom prescription formulations nationwide. The cGMP guidelines that Hallandale Pharmacy is led by our Quality Assurance team and supporting staff. While quality is the foundation of our practice, our service to our patients and providers drives our mission. We regard our relationships with our trusted practitioners as a partnership.

Heart Care Corp.

Booth #4045

25 E. Main Ste # 207, Chattanooga, Tennessee, 37408 | USA

Ph: (865) 384-1385

Email: info@heartcarecorp.com www.heartcarecorp.com

Heart Care Corp. is the U.S. authorized distributer of Premier Heart’s Multifunction Cardiogram™. This groundbreaking AI device is FDA approved and has already been used to test over 2 million patients worldwide. In a 10-minute noninvasive and riskfree scan, MCG™ offers physicians unprecedented accuracy in early detection of CVD and the opportunity for intervention and reversal. It’s the most comprehensive view of the heart available, surpassing the gold standard, and revealing things about the heart we’ve never seen before.

HansBiomed

USA Inc. (MINT PDO)

Booth #2048

140 Sylvan Ave.,Ste.301

Englewood Cliffs, New Jersey, 7632 | USA

Ph: (201) 224-2333

Email: hansusa@hansbiomed.com www.mintpdo.com

The award-winning global brand, MINT™ offers the most robust PDO threads on the market. In 2020, it became the only medical device of its kind with dual FDA clearances. MINT™ is backed by multiple clinical studies for its efficacy & manufactured through an innovative patented technology to offer a broad product portfolio. HansBiomed USA Inc., makers of MINT™ PDO threads, is committed to working with physicians to deliver safe, innovative, & meaningful treatments.

Hawaiian Moon Booth #3095

1226 Turner St., Clearwater, Florida, 33756 | USA

Ph: (888) 256-3276

Email: customerservice@hmaloe.com www.aloecream.biz

Say Goodbye to Dry Skin with Hawaiian Moon Organic Aloe Cream! It is free of dyes, fragrance, parabens, sulfates, mineral oil_, and any other harsh chemicals, including petroleum. Our cream penetrates the skin up to 7 layers deep, and absorbs into the skin instantly.

Healthgevity

Booth #8023

51 NE 24th Street,Suite 206 Miami, Florida, 33137 | USA

Ph: (833) 940-4898

Email: support@healthgev.com www.healthgev.com

Healthgevity collaborates with leading healthcare professionals and organizations around the globe to translate breakthrough science into advanced nutritional supplements. Healthgevity is focused on developing natural solutions that support healthy aging, increased healthspan and prevention.

HealthyLine

Booth #5099

515 7th Ave., New York, New York, 10018 | USA

Ph: (212) 300-5092

Email: store@healthyline.com www.healthyline.com

HealthyLine’s revolutionary PEMF mats and farinfrared mats are designed to improve your health and wellness using natural gemstone heat therapy. Our nature-inspired medical devices will enable you to feel good all year round. Gain a complete wellness experience with a combination of up to 5 therapies. Rejuvenate your body from the inside out when you receive the benefits of PEMF, Heat, FIR, Negative Ion, and Photon Light Therapies.

Hormone Therapy

Centers of America

Booth #7065

5 Cowboys Way,Suite 300

Frisco, Texas, 75034 | USA

Ph: (469) 213-2792

Email: tyrichardson@ht-ca.com www.HT-CA.com

HTCA partners with practices to provide a full turnkey solution to implementing Bioidentical Hormone Replacement Therapy into your Practice, Clinic, or Med Spa. Our program consists of five key components: training, dosing, materials, marketing, and support.

Houston Enzymes

Booth #3081

116 N Broadway,Suite G

Siloam Springs, Arkansas, 72761 | USA

Ph: (866) 858-3779

Email: tim.terry@houston-enzymes.com www.houston-enzymes.com

Houston Enzymes specializes in digestive enzyme products. Our company is led by enzyme biochemist Devin Houston, PhD. Houston Enzymes’ formulations support the digestion of gluten, casein, soy, proteins, carbohydrates, fats, and polyphenols. We offer targeted enzymes for specific food intolerances as well as gut microbiome support. Available in capsule, chewable tablet, and powder forms.

Hue Light USA

Booth #4071

146 Rock Hill Dr, Rock Hill, New York, 12775 | USA

Ph: (845) 796-9951

Email: info@huelightusa.com www.HueLightUSA.com

HUE LIGHT creates premium treatment technology for advanced anti-aging and longevity clinics. We are clinical results driven! Our BAHI Therapy System combines BioPhoton Light with Nogier Frequencies, Hyperbaric Oxygen, Nebulized Hydrogen, and Pulsation in a precision approach to immune health and chronic disease treatment. Patients feel a difference which encourages compliance to your treatment plan. HUE LIGHT equipment is manufactured in Korea. We invite you to experience HUE LIGHT for yourself.

Immun’Âge

Booth #3093

3450 Cahuenga Blvd West Apt # 508, Los Angeles, California, 90068 | USA

Ph: (323) 848-4260

Email: contact@immunage.us www.immunage.us

OSATO USA is the American distributor branch for Immun’Âge®, an all-natural 100% fermented papaya dietary supplement to strengthen the body’s defense systems and slow down the aging process. Through a 10-month proprietary fermentation process, papaya is transformed into FPP® (Fermented Papaya Preparation), combining the benefits of the fruit and those of fermented foods. FPP® properties have been demonstrated by 52 clinical studies. Immun’Âge®, is marketed worldwide with more than 15 million packets sold annually.

Immunocine Cancer Center

Booth #9042

3422 Business Center Dr., Pearland, Texas, 77584 | USA

Ph: (888) 575-2572

Email: care@immunocine.com www.immunocine.com

The Immunocine Cancer Center provides one of the most advanced Cancer Immunotherapies available, which is currently being studied in multiple FDA Clinical Trials. Backed by research and clinical success across a variety of cancers, Immunocine is providing its revolutionary approach to Dendritic Cell Treatments for the cancer patients of today seeking the cancer treatment of tomorrow.

Immunosciences Lab, Inc.

Booth #1035

822 S. Robertson Blvd.,Ste.312

Los Angeles, California, 90035 | USA

Ph: (310) 657-1077

Email: immunsci@gmail.com www.Immunoscienceslab.com

Immunosciences Lab., Inc. (ISL) is a state-of-the-art clinical reference and research laboratory, a leader and innovator in the field of molecular medicine. Licensed in California and CAP-approved, ISL specializes in utilizing the most highly sensitive and accurate testing methods for detecting lyme disease, autoimmunity, gluten sensitivity and viral infection. ISL’s unique tests have resulted in several patents and are the product of over 4 decades of meticulous training, painstaking research, and extensive clinical laboratory experience.

Imprimis Rx

Booth #3044

1000 Aviara Parkway,Ste. 220

Carlsbad, California, 92011 | USA

Ph: (844) 446-6979

Email: info@imprimisrx.com www.imprimisrx.com

At ImprimisRx we work hard every day to earn your trust by providing quality products and exceptional service! Please let us know how we can continue to improve via the Chat feature on imprimisrx.com. Thank you for allowing us to serve you and your patients!

InBody

Booth #3100

Unit C, Cerritos, California, 90703 | USA

Ph: (323) 932-6503

Email: convention@inbody.com www.inbodyusa.com

For 25 years, InBody has revolutionized body composition. Trusted by specialists in the antiaging, functional, and regenerative medicine fields, InBody DSM BIA devices deliver detailed biometrics to help holistically treat and prevent diseases. In seconds, the InBody Test yields vital metrics like body fat percentage, visceral fat analysis, and BMR, allowing physicians to tailor treatments, predict patient outcomes, and monitor long-term progress for sustained health and wellness.

Innergy Development, LLC

Booth #4061 & 5061

545 E University Pkwy,Suite 200 Orem, Utah, 84058 | USA

Ph: (385) 208-9200

Email: heather@innergydev.com www.innergydev.com

Brain Science and Alternative Wellness Technologies. INNERgy Development Technologies are non-invasive and state-of-the-art tools. Whether you are a clinician or just an individual, our innovative technologies may support you on your journey towards optimal health and wellness. We bring you the latest in technology, with a price tag that you can afford.

Integrative Peptides

Booth #2042

2232 E. Maple Ave., El Segundo, California, 90245 | USA

Ph: (310) 955-6278

Email: lori@integrativepeptides.com www.integrativepeptides.com

Founded in 2018, Integrative Peptides provides innovative best-in-class peptide supplements that meet the highest standards for safety and purity at a fraction of the cost. Integrative Peptides was born out of the idea that there had to be a better way for patients and their healthcare providers to gain access to safe peptide supplements without a needle.

INTEGR ATIVE PRP

IntegrativePRP

Booth #9023

953 Franklin Avenue,Suite 200 Garden City, New York, 11530 | USA

Ph: (518) 648-3388

Email: contact@integrativeprp.com www.integrativeprp.com

Integrative PRP offers one of the leading systems in therapeutic autologous biologics. Integrative PRP supplies FDA cleared PRP centrifuges and PRP kits for hair restoration, facial aesthetics, sexual wellness and pain management. Our products meet the highest level of quality and efficacy producing the best desired and intended results. We provide virtual and on-site training, free practice kits, and on-demand support to help you get started. We look forward to starting a collaborative long-term relationship!

International Hyperbarics Association

Booth #7036

33 Woodcroft Circle, Madison, Wisconsin, 53719 | USA

Ph: (877) 442-8721

Email: info@ihausa.org www.ihausa.org

The International Hyperbarics Association is a 501(c)3 organization focused on sharing the benefits of hyperbaric oxygen therapy within the medical industry and consumers alike for nearly two decades. Representing medical professionals and clinics, our membership reflects a passionate collective committed to achieving a better quality of life through HBOT. Our mission is to educate the community on the benefits of hyperbaric therapy and provide accessibility for those in need to improve health and wellness.

Japan Bio Products Co., Ltd.

Booth #2061

1-30-22 F4,Maple Wood Building Tokyo, Tokyo, 1510063 | Japan

Ph: 813-680-49643

Email: y_ochiai@placenta-jbp.co.jp www.jbpglobal.placenta.co.jp

Established in 1954, JBP (Japan Bio Products Co., Ltd.), is the world leading pharmaceutical company in the area of the placental extract based products. Manufacturing and selling pharmacutical injections, skincare cosmetics, food supplements, pets’ supplements and medical devices. Research and Develop the effective application of various features of placental extracts in the sphere of medical treatment, health and beauty culture.

Jigsaw Health Booth #

2044

9035 E. Pima Center Pkwy,Suite 3 Scottsdale, Arizona, 85258 | USA

Ph: (480) 951-0840

Email: kate@JigsawHealth.com www.JigsawHealth.com

Since 2005, Jigsaw Health (aka. “The Magnesium People”) has been developing the highest-quality nutritional supplements with a focus on Magnesium featuring Sustained Release Technology (w/SRT®), which controls the release of active ingredients so absorption can happen over time. MagSRT® by Jigsaw Health is America’s #1 Time Release Magnesium® with over 1,000 five-star Amazon reviews (five times more than the second-closest brand) and clinically shown to increase Magnesium in the body.*

Jinfiniti: The Longevity Biomarker Company Booth

#5093

1235 Walton Way, Augusta, Georgia, 30901 | USA

Ph: (214) 679-0059

Email: kjohnsen@jinfiniti.com www.Jinfiniti.com

Jinfiniti is a scientist led, data driven company that is dedicated to empowering clinicians and individuals to optimize their health, performance and longevity. We provide analysis of actionable longevity biomarkers including NAD and cellular senescence.

Kajarin, Inc

Booth #5090

1204 N. 7th St.,,Suite 104 Grand Junction, Colorado, 81503 | USA

Ph: (800) 683-7449

Email: cs@kajarin.com www.kajarin.com

Kajarin provides a line of hormone creams for practitioners. Kajarin products are your partner in guiding your women patients through puberty, pregnancy, post partum, perimenopause, menopause, and into post menopause. Men experience hormonal changes too and, while less dramatic than fluctuations experienced by women, they can benefit from hormone supplementation for a range of andropausal symptoms including weight gain, low testosterone, night sweats, foggy thinking, fatigue. Kajarin provides affordable, long term hormone supplementation solutions.

Kalyagen

Booth #5102

1205 Sheldon Cove Building # 1,Suite # H2 Austin, Texas, 78753 | USA

Ph: (833) 525-9436

Email: info@kaylagen.com www.kalyagen.com

Kalyagen™ is the world’s leading biotechnology company in the development of natural plant-based Stem Cell Enhancers. Deeply rooted in science and innovation, Kalyagen™ is focused on the investigation and development of plant extracts that stimulate or support Endogenous Stem Cell Mobilization (ESCM). Kalyagen™ has pioneered the development of novel botanicals and nutraceuticals aimed at supporting optimal health. STEMREGEN® is the first product developed by Kalyagen™. STEMREGEN® is a unique proprietary blend of plant-based extracts documented to support ESCM.

Kashi Clinical Laboratories

Booth #7063

9570 SW Barbur Blvd., Portland, Oregon, 97219 | USA

Ph: (503) 206-4989

Email: tthomas@kashilab.com www.kashilab.com

Kashi Clinical Laboratories is a fully-accredited lab that specializes in a range of genomic healthcare services from HLA testing for Bone Marrow Transplants to UA /drug testing, genetic testing and now COVID19 testing. Kashi Lab offers a distinctive one-on-one approach in developing laboratory services to meet organization and project requirements. We promote well-being and quality of life by delivering the highest standard of laboratory work. We recognize our service as more than a test result.

Steven K. Scott

Co-founder of Biotech Nutritional Sciences (BNS), The American Telecast Corp and Total Gym Fitness, has worked with top glutathione researchers from around the world for 16 years. He has pursued and funded technologies since 2006 to enhance glutathione absorption and effectiveness. His latest company, Biotech Nutritional Sciences created a breakthrough proprietary technology for nano-sizing biologics including glutathione, L-cysteine, plus other peptides and nutrients. BNS’s Hydrastat® Nano-Delivery System has achieved levels of bioavailability and cellular utilization rarely seen, producing beyond extraordinary outcomes in health and human performance. He is a NY Times best-selling author of nine international best sellers, with a new book just released: ‘The Joseph Principles’. His various nutritional brands, including Neumi®, are currently sold domestically and internationally in 32 countries.

KBMO

Booth #3027

4 Business Way, Hopedale, Massachusetts, 2332 | USA

Ph: (617) 933-8130

Email: jwhite@kbmodiagnostics.com www.kbmodiagnostics.com

The FIT Test is the only patented food sensitivity test on the market. It uses a multiple pathway approach looking at food sensitivities, inflammation, and leaky gut from one test. We now also include the gut barrier panel which includes our Zonulin assay, a personalized meal plan and patient app. We have an FDA Registered and ISO 13485 manufacturing facility and a CLIA High Complexity Laboratory based near Boston, Massachusetts.

Kimera Labs

Booth #5085

2810 N. Commerce Parkway, Miramar, Florida, 33025 | USA

Ph: (305) 454-7836

Email: info@kimeralabs.com www.kimeralabs.com

A leading exosome biotechnology laboratory specializing in the production of perinatal mesenchymal stem cell-derived (MSC) exosome products for cosmetic use and scientific and clinical research.

medical technologies

Kinas Medical Technologies

Booth #8084

541 Village Trace,Bldg.11, Ste.102 Marietta, Georgia, 30067 | USA

Ph: (770) 612-8245

Email: info@kinasmedical.com www.kinasmedical.com

Enhance your patient’s experience with the clinically proven, non-invasive shockwave modality trusted by medical professionals around the world for both regenerative and aesthetic applications. A partnership with Kinas Medical takes you further, faster. As a family-owned business with over 30 years of experience with shock wave technology, Kinas Medical provides dedicated support and a customer-focused business model that prioritizes both your patients and your business. Take your progressive therapies to the next level!

KnowingLabs

Booth #8064

1101 E. Dallas Ave., Ste.5, McAllen, Texas, 78501 | USA

Ph: (512) 855-1295

Email: dc@knowinglabs.com www.knowinglabs.com

For over a decade, KnowingLabs has empowered individuals like you to take a proactive approach to their health. Our customized at-home laboratory tests are designed to take out the guesswork helping you to maximize your overall health and well-being by making educated decisions. We want you to perform at your best in all areas of your life; our test panels have been clinically designed to enhance your mental, physical, emotional, and sexual health.

Koncentrated K

Booth #3078

535 Delta Ave, Manistique, Michigan, 49854 | USA

Ph: (715) 612-5858

Email: koncentratedk@yahoo.com www.k-vitamins.com

Vitamin K is an indispensable vitamin, and many people are deficient. Koncentrated K contains a therapeutic dose of vitamin K1, MK4, MK7, along with astaxanthin. At our website, www.k-vitamins. com, we summarize the peer-reviewed research on vitamin K and the vital role that Vitamin K and its derivatives, play in the well-being of the body. With sufficient intake of vitamin K, research shows that the risk of chronic disease is greatly reduced.

Kyani

Booth #6095

880 W 800 N, Mapletown, Utah, 84664 | USA

Ph: (801) 717-7962

Email: kaylenecandrew@gmail.com www.eastbaywellness.kyani.com

Kyani is a health and wellness company which prides itself in “Wellness Simplified”. Our focus is quality over quantity. We offer whole food, fullspectrum, liquid nutrition supplements. It’s like juicing in a pouch! The ingredients are cold pressed naturally sourced from wild grown foods to ensure the most natural and bioavailable form of vitamins and minerals for daily consumption. Experience the power of Nitro Nutrition! Our mission is to bring hope through wellness and opportunity.

Lasso MD

Booth #2073

5703 Oberlin Dr., Ste.306, San Diego, California, 92121 | USA

Ph: (801) 842-1950

Email: otis@lassomd.com www.Lassomd.com

Lasso is a marketing company that focuses on bringing innovative patient acquisition techniques to the dental industry with a proven track record. Everything we do emanates emotion, inspires engagement, and enables enrichment around that one purpose. We’re all about creating value. We’re passionate about what we do... and how we do it. We trust in each other and in our abilities to create something special, something unique, something impactful. We make the difference... for our team, our customers, our partners!

Life Support Health Products

Booth #7086

800E. 101st Terr.,Ste. 100 Kansas City, Missouri, 64131 | USA

Ph: (816) 673-1230

Email: officemanager.tehc@gmail.com www.lifesupporthp.com

As a company, we seek to create the highest quality supplements that exist in the world. All products are created by a functional medicine doctor who is currently in practice. We have solved the problem of having to take too many pills by creating concentrated products that deal with all aspects of a patients biochemistry. We know compliance is key for a patient to get a result and start referring. Let the healing begin.

LightStim

Booth #3046

16552 Von Karman Avenue, Irvine, California, 92606 | USA

Ph: (949) 502-4088

Email: tracey@lightstim.com www.lightstim.com

Throughout the past two decades LightStim has earned a reputation as a trusted manufacturer of the highest quality LED technology used for low level light therapy (LLLT) in the world. FDA cleared and designed to treat multiple conditions, all LightStim devices are manufactured in the USA at our corporate headquarters. In house manufacturing ensures that attention to detail, quality control, and rigorous product testing practices are adhered to in the production of every device.

Lionheart Health, Inc.

Booth #2088

1 Kent Court, Mission Viejo, California, 92694 | USA

Ph: (424) 291-2133

Email: info@lionhearthealthstim.com www.lionhearthealthstim.com

Lionheart Health, Inc. is developing bioelectric and biologic innovations to help people live longer and healthier lives. The company is featuring its FDA-cleared BodStim, a bioelectric bodysuit that augments exercise. Forty minutes of exercise in a BodStim suit can produce the benefits of up to 2 to 4 hours of exercise without it. Importantly, BodStim includes bioelectric signaling sequences to control the release of Klotho, a powerful muscle-building protein with potential anti-aging benefits, according to over 3,000 scientific papers. www.klothoyears.com/scientific-articles

Live To Be Well LLC

Booth #9022

POBox 12604, Glendale, Arizona, 85308 | USA

Ph: (602) 931-9526

Email: worldteam21@yahoo.com www.compoundinginterestinfo.com

We are consultants that have approximately 20 full time professional traders with a history of providing an AVERAGE ROI of 3% WEEKLY to all of it’s members for the past 3+ years. We are helping provide passive income to Physicians and families all around the world! Join with thousands of people around the world who are earning a passive income every week for simply participating in our fund.

LivOn Labs

Booth #6067

2654 W. Horizon Ridge Pkwy,Ste. B5-108 Henderson, Nevada, 89052 | USA

Ph: (866) 790-2107

Email: rachael@livonlabs.com www.LivOnLabs.com

LivOn Labs is the first dietary supplement company to utilize liposomal encapsulation technology, releasing the original liposomal Vitamin C in 2004. Our patented Lypo-Spheric® technique encapsulates nutrients —which are ordinarily difficult to absorb when taken orally —in double-layer spheres (liposomes) that pass through the intestinal wall and into the bloodstream. Based in Las Vegas, the family-run company now has distribution in more than 70 countries. Sample our supplements at booth 6067.

L-Nutra

Booth #4005

5905 Legacy Dr,suite 5

Plano, Texas, 75024 | USA

Ph: (310) 775-3655

Email: aperez@l-nutra.com www.l-nutra.com

At L-Nutra, we’re spearheading a global movement to turn sick care into health care. We believe food – one of the few things you consume continually – is a key to health, longevity and preventing and curing disease. We’re using groundbreaking science and natural, plantbased solutions to prove it. In short, we’re here to change the world and usher in an entirely new kind of proactive health care. This is the nutritech revolution.

Longevity Labs

Booth #1052

1550 Wewatta St.,STE 200 Denver, Colorado, 80202 | USA

Ph: (303) 590-3507

Email: contact@spermidinelife.com www.spermidinelife.us

Longevity Labs+ is a health start up, focused on improving the aging process. Our mission is to translate scientific findings into natural solutions so people can live longer, healthier lives. With supplementation of spermidineLIFE®, our spermidinerich wheat germ dietary supplement, research shows the process of autophagy is induced and cellular rejuvenation is activated. This results in immense benefits from boosted immune system to protection from cognitive decline and much, much more. The research is clear: life is better with autophagy!

McGuff Medical Inc.

Booth #1020

3524 West Lake Center Dr., Santa Ana, California, 92704 | USA

Ph: (714) 545-2491 x224

Email: answers@mcguff.com www.McGuff.com

McGuff Company Inc. is a wholesale distributor of over 5,000 competitively prices pharmaceuticals, IV related products, physician office & exam room supplies and an extensive oral nutritional line to support your patient’s treatments. Our experienced customer service staff are experts at finding hard-to-find products. We maintain close relations with both large and small manufacturers of quality products to assure we will meet all of your needs. Competitive prices for over 50 years!

Med Results, Inc.

Booth #7061

412 W Broadway,Ste # 303

Glendale, California, 91204 | USA

Ph: (818) 396-4496

Email: office.admin@med-results.com www.med-results.com

At Med Results, we are dedicated to providing innovative solutions in the aesthetic industry by bringing high-class products and technologies to your fingertips. We are the manufacturers of new Italian-made tech like the Plexr Pure Plasma Pen, HDPDO threads, and the Canadian Uplifting creams. Our amazing team at Med Results is committed to bringing the tech of the future into your hands today. We promise to improve your perception of results because Results Matter!

Medeia Inc.

Booth #8066

7 W. Figueroa St., Ste.215, Santa Barbara, California, 93101 | USA

Ph: (800) 433-4609

Email: info@medeia.com www.medeia.com

Since its inception in 1992, Medeia Inc has been on the forefront in the manufacture and distribution of Neuro Diagnostic and Heart Rate Variability / ANS products. Medeia Inc specializes in the development of state of the art biometrical software and hardware products intended to monitor physiology for research and educational purposes.

Medico

Booth #3098

500 N State College Blvd,Ste #1100 Orange, California, 92868 | USA

Ph: (949) 508-5605

Email: customerservice@medicobiomed.com www.medicobiomed.com

Our Medico Bio Corp produces FDA Cleared PDO Threads which are in great quality with latest technology. Our mission is to provide the leading industry of PDO threads with an unbeatable quality and to coordinate with all physicians and nurses with low price compared to other companies. Our threads are called Accel PDO Threads which come in various sizes that fulfill the needs of different preferences that each practitioners own themselves.

Medisca

Booth #7095

661 Route 3 Ste # 3, Plattsburgh, New York, 12901 | USA

Ph: (800) 932-1039

Email: MUS-CustomerServices@medisca.com www.medisca.com

Medisca® Medisca is a global corporation with locations throughout North America, Australia, and Europe, that contributes to healthcare by leveraging strong partnerships that deliver customized solutions with an unwavering commitment to quality. Backed by 30+ years and a strong foundation in pharmaceutical compounding, Medisca delivers extensive solutions as Partners in Wellness.

Medizap

Booth #2091

600 B Street,Suite 300

San Diego, California, 92101 | USA

Ph: (775) 386-6677

Email: customerservice@medizap.co www.medizap.co

MediZap is the only contract terminal sterilizer built for compounding for 503a, 503b, and small pharma, featuring E-Beam | X-Ray sterilization services. Our 4 Pillar Service includes Sterilization, Packaging Solutions, Compliance, and Regulatory. We offer exclusive line capacity, group pricing, and shared industry knowledge. USP 797 guidelines require terminal sterilization, and MediZap is the most advanced and superior solution. Our technology delivers 10-6 sterility assurance but has proven 10-7, ensuring the safety and efficacy of your compound while mitigating risk.

Merchant Preferred Zero Booth #

9027

170 Chestnut Ridge Road, Queensbury, New York, 12804 | USA

Ph: (540) 484-3429

Email: dgalbraith@merchantpreferred.com www.mpzero.net

Merchant Preferred Zero lets the business owner stop paying merchant processing fees. Growing their monthly profit year after year. This is ideal for any business and simple to integrate. Credit card fees should not be a cost of doing business. MPZero provides the hardware at no cost.

Meridian Valley Lab

Booth #1034

6839 Fort Dent Way, Tukwila, Washington, 98188 | USA

Ph: (206) 209-4194

Email: ajohnson@meridianvalleylab.com www.meridianvalleylab.com

Meridian Valley Lab A World Leader in Food Sensitivity and Hormone Testing. Our pioneering spirit is in large part due to our Medical Director, Dr. Jonathan Wright, and his fearless dedication to serving humanity since 1976. We are proud of our comprehensive, extensive internal quality control and quality assurance measures, we participate in proficiency testing services with the College of American Pathologists and the American Association of Bioanalysts.

2611 N. San Fernando Road, Los Angeles, California, 90065 | USA

Ph: 800-69-MERIT1

Email: solutions@meritpharm.com www.meritpharm.com

Offering IV Infusion from Merit? Getting your med/ surg/pharma from us? Your colleagues are and they have higher profits. Merit supplies Anti Aging/ Aesthetic/Integrative practitioners better prices on the products you use. Stop by our booth and learn why successful clinics partner with Merit. IV Therapy Nutrition/Hydration, Weight Loss, Hormones, IV solutions, PRP products, exam/surgical supplies and more. Merit offers pharmaceuticals (2, 3, 3N, 4), and related medical products. www. meritpharm.com or (800) 69-MERIT!

Metagenics

Booth #6032

25

Ph: (800) 692-9400

Email: Info.customerservice@metagenics.com www.metagenics.com

Metagenics was founded on a revolutionary idea: Our genes do not predetermine our health potential, and through nutrition, we can impact how our genes express themselves. Embodied by our company motto—genetic potential through nutrition—this groundbreaking principle drives us to deliver high-quality, science-based nutritional supplements, medical foods, and lifestyle programs to support healthcare practitioners in their efforts to help patients achieve their health and wellness goals. To learn more: Visit Metagenics.com

MERCHANT PREFERRED ZERO

Microbiome Labs

Booth #3009

11555 183 Place,Suite D

Orland Park, Illinois, 60467 | USA

Ph: (904) 940-2208

Email: info@gomegaspore.com www.microbiomelabs.com

Microbiome Labs is a company focused on improving health outcomes through the modulation of the gut microbiome. The company was built upon three major pillars: clinical research, education, and product innovation. This unorthodox approach is far and away what continues to set Microbiome Labs apart from the rest of the supplement industry. We strive to create unique and effective solutions that help practitioners change lives all over the world.

Mito Q Ltd.

Booth #6087

139 Pakenham Street West,Ground Floor Auckland, Auckland, 10101 | New Zealand

Ph: (760) 822-4833

Email: caprice@mitoq.com www.MitoQ.com

MitoQ is a positively-charged antioxidant health brand, created with world-first, multipatented biotechnology in New Zealand.

MyAdvice

Booth #8072

1850 West Ashton Blvd. Ste 500, Lehi, Utah, 84043 | USA

Ph: (435) 575-7470

Email: sales@myadvice.com www.myadvice.com

Your business needs to be online to stand a chance against your competitors. MyAdvice provides a proven, comprehensive suite of products designed to simplify and maximize your marketing efforts and increase revenue. Transform your practice with any of our Digital Marketing Power Suite products. No matter your practice’s needs, we have a wide selection of products that are made to improve your online presence.

Myers Cocktail, Inc

Booth #2036

2816 11th Street NE,301 Calgary,, Alberta, T2E7S7 | Canada

Ph: (403) 928-3624

Email: TCS@NutraGroupInc.com www.myerscocktailoral.com

Myers Cocktail Oral Therapy (MCOT) takes the benefits IV therapy to the next level, without the IV and into your home! MCOT is a nutraceutical powdered supplement that is therapeutically dosed to maintain micronutrient levels in the body, support human metabolism, ensure proper hydration, slow sarcopenia and increase natural energy levels throughout the whole day. For anyone who is feeling “sick & tired,” MCOT is a costeffective solution to get you “well and energized.”

Mymycolab, LLC

Booth #2079

17849 Hunting Bow Circle Ste # 102, Lutz, Florida, 33558 | USA

Ph: (281) 796-1140

Email: testing@mymycolab.com www.mymycolab.com

BLOOD SERUM ANALYSIS FOR 12 DIFFERENT MYCOTOXINS: THE MOST PRECISE TEST FOR THE EFFECTS OF INDOOR MOLDS. Mymycolab tests blood serum for 12 mycotoxin antibodies, with both IgG and IgE antibodies for each. It is a biomarker for exposure to molds/mycotoxins in an indoor environment. Our testing is used worldwide. IgG antibodies to mycotoxins indicate a toxic reaction to mycotoxins from molds in an indoor environment; IgE antibodies to mycotoxins indicate mast cell activation.

ellness nbx

Nature’s Sunshine Products

Booth #7070

2901 W. Bluegrass Blvd.,Ste.100 Lehi, Utah, 84043 | USA

Ph: (800) 223-8225

Email: www.naturessunshine.com www.naturessunshine.com

Nature’s Sunshine Products (Nasdaq: NATR), a leading natural health and wellness company, markets and distributes nutritional and personal care products in more than 40 countries. Nature’s Sunshine manufactures most of its products through its own state-of-the-art facilities to ensure its products continue to set the standard for the highest quality, safety and efficacy on the market today. Additional information about the company, and its aggressive sustainability and social goals can be obtained at its website, www.naturessunshine.com.

NBX Wellness

Booth #3079

13376 N. Hwy. 183,Suite 126 Austin, Texas, 78750 | USA

Ph: (866) 500-5388

Email: info@nbxwellness.com www.NBXWellness.com

NBX Wellness (formerly Neurobiologix) empowers wellness professionals like yourself to make personalized supplementation recommendations while increasing your income. With our advanced technology and integrated wellness testing, you’ll personalize your very own eStore to provide your patients with access to our proprietary and patented supplements. We’ll pay you weekly and ship orders directly to your patients. Our goal is to improve your business’s and your patients’ wellness. Stop by our booth to learn more!

Neo 7 Bioscience Booth #3049

539 W. Commerce St., Ste.2886, Dallas, Texas, 75208 | USA

Ph: (469) 619-7252

Email: info@neo7bioscience.com

Neo7 Bioscience is a precision molecular solutions company. Our AI-based technology platform

Neobiosis

Booth #1047

305 SW 7th Terrace, Gainesville, Florida, 32601 | USA

Ph: (864) 353-5781

Email: Kathy@Neobiosis.com www.neobiosis.com

Neobiosis is a clinical stage CDMO manufacturing company focused on tissues, cells and EVs from perinatal sources for use in regenerative medicine.

Neumi® Independent Members with Doctors Nano LLC Booth #4104

PO Box 3136, Jupiter, Florida, 33469 | USA

Ph: (888) 321-1235

Email: info@DoctorsNano.com www.DoctorsNano.com

Neumi® manufactures glutathione and related peptide/nutrient formulas via HydroStat® NanoTechnology. This proprietary process uses ultrapure water to maximize absorption, bioactivity and efficaciousness, achieving cell penetration within seconds. Steven K. Scott, 16-year glutathione expert, acclaimed author and famed TV infomercial master, co-founded Neumi® to empower people to lead extraordinary lives. Doctors Nano LLC represents Neumi® independent members who distribute Neumi® formulas to empower health professionals and their clients with affordable, convenient and powerful supplements for health, performance and anti-aging.

NuMedica

Booth #7032

9503 E. 55th Place, Tulsa, Oklahoma, 74145 | USA

Ph: (800) 869-8100

Email: projectmanager@numedica.com www.numedica.com

NuMedica® is an NSF® GMP Certified, FDA registered company implementing the latest quality control standards in manufacturing and testing of our formulas. Our formulas are designed with active ingredients for higher performance along with advanced nutrient delivery methods and Enhanced Absorption Technologies™ offering value through increased bioavailability.

NuSkin Booth #2055

2251 N. Rampart Blvd,Suite 353

Las Vegas, Nevada, 89128 | USA

Ph: (702) 363-5343

Email: russ.karlen@gmail.com www.nuskinusa.com

AgeLOC Youth delivers an all-encompassing anti-aging protection. It promotes a wide range of functions from your heart to your brain, your bones to your metabolism. A variety of aging aggressors cause us to age, but our aging defense mechanisms help keep us young. Now you can hold onto your youth so you can keep doing what you love throughout your life.

Nutrafol

Booth #7071

136 Madison Ave.,Floor 10 New York, New York, 10016 | USA

Ph: NA

Email: nutrafol@behrmanpr.com www.Nutrafol.com

Nutrafol is the category creator of hair wellness, providing an innovative, science-backed approach to hair health in men and women. Nutrafol’s clinically effective hair growth nutraceuticals target the underlying causes of thinning hair - like stress, hormones, environment and nutrition -- and use a patented blend of medical-grade botanicals and standardized ingredients to support whole body health from within. Nutrafol is currently recommended by over 3,000 healthcare providers and hair professionals for trusted, reliable results.

Nutramax Laboratories

Consumer

Care, Inc.

Booth #4103

946 Quality Dr., Lancaster, South Carolina, 29720 | USA

Ph: (803) 298-6000

Email: contactus@nutramaxlabs.com www.nutramaxlabs.com

Avmacol® and Avmacol® Extra Strength with beta glucans for immune health support, by Nutramax Laboratories Consumer Care, Inc. are formulated with glucoraphanin and active myrosinase enzyme supporting production of sulforaphane to help increase phase 2 enzyme activities essential for elimination of certain toxins. The brand chosen for numerous clinical trials.

NutriDyn

Booth #5045

5414 Hwy.12, PO Box 219, Maple Plain, Minnesota, 55359 | USA

Ph: (800) 444-9998

Email: info@nutridyn.com www.nutridyn.com

NutriDyn is proud to be a 3rd generation familyowned business that continues to focus on providing healthcare professionals with premium-quality nutritional supplements and educational services to optimize the health of their patients. We pride ourselves on continually providing cutting-edge research and products to our partners in health by hosting conferences, workshops, and seminars. The purity of ingredients, reliability of claims, and product effectiveness is why many practitioners worldwide trust NutriDyn as their partner in health.

Oligoscan (Springdale Health Management)

Booth #3114

167 Springdale Rd., Venetia, Pennsylvania, 15367 | USA

Ph: (412) 320-1576

Email: info@theoligoscan.com www.theoligoscan.com

Intracellular Test for Heavy Metals, Minerals, and Trace Elements via Spectrophotometry. 43 Elements reported (21 minerals, 15 heavy metals, and Vitamins A, B6, B9, B12, C, D, & E). The test is immediate and is non-invasive, measuring the tissue of the palm of the hand. An invaluable screening tool for actual tissue levels (intracellular) and what the body has retained/accumulated over the course of one’s life.

Olympia Pharmacy

Booth #7033

6700 Conroy Road,STE 155

Orlando, Florida, 32835 | USA

Ph: (407) 673-2222

Email: sales@olympiapharmacy.com www.olympiapharmacy.com

At Olympia Compounding Pharmacy, we understand the importance as well as the necessity of offering both 503A and 503B compounding pharmacy capabilities. Each of these designations of compounders plays a crucial role in filling today’s compounding landscape. With our two separate, state-of-the-art facilities, Olympia supports both patient-specific and office-use needs across the U.S., enabling our customers to comply with all national and state regulatory requirements while having the convenience of a single-source pharmacy partner.

Omega Diagnostics Ltd Booth #3099

Henry Crabb Road,Littleport Cambridgeshire, England, CB6 1SE | United Kingdom

Ph: 0044 (0)1353 863279

Email: hello@CNSLab.co.uk www.cnslab.co.uk

Omega is an international diagnostics testing business that is passionate about improving lives around the world by accurately informing health decisions. Collaborating with laboratories and partner organisations, we provide world-leading food sensitivity tests in over 60 countries. We passionately believe in promoting a more personalised approach to health. Using pioneering diagnostic technologies, we enable healthcare professionals and their patients to accurately identify lifestyle and dietary changes that can significantly improve long-term health and well-being.

OmegaQuant

Booth #2060

5009 W. 12th Street,Ste.8

Sioux Falss, South Dakota, 57106 | USA

Ph: (800) 949-0632

Email: jason@omegaquant.com www.omegaquant.com

OmegaQuant, an independent, CLIA-certified lab, offers Omega-3 Index, Vitamin D, Prenatal DHA, Mother’s Milk DHA, Vitamin B12 and HbA1c testing to researchers, clinicians and consumers. We perform our analyses in Sioux Falls, SD, for commercial and academic research collaborators, and for consumers interested in monitoring their nutritional status in blood, urine, and breast milk. Our goal is to offer the highest quality analytical services and advance the science and use of nutrients to improve health.

Ortho Molecular Products

Booth #4027

Floor 2, Barrington, Illinois, 60010 | USA

Ph: (815) 206-6541

Email: l.grendel@ompimail.com www.orthomolecularproducts.com

For over 30 years, Ortho Molecular Products has partnered exclusively with health care providers to deliver nutritional solutions of the highest efficacy. The most trusted voices in health care put their trust in our products to help patients get better, faster. Our commitment to science, careful raw ingredient selection, and strict quality standards goes into every supplement we formulate. To learn more, visit www. orthomolecularproducts.com or call 1-800-332-2351.

OutcomeMD

Booth

145 S Fairfax Ave,Ste 200 Los Angeles, California, 90048 | USA

Ph: (878) 688-2663

Email: sales@outcomemd.com www.outcomemd.com/a4mconference

OutcomeMD, Inc., based in Los Angeles, CA, is a digital outcome tracking platform that helps healthcare professionals elevate care and allows patients to celebrate their medical outcomes. Patients are empowered with coordinated care, timely symptom management and medical goal transparency. Providers receive data that informs treatment decisions and drives new business. OutcomeMD is delivering the future of healthcare today!

Outset

Booth #9032

6830 Spencer St,Ste. 102

Las Vegas, Nevada, 89119 | USA

Ph: (702) 340-7727

Email: rea@outsethealth.com www.OUTSETHEALTH.COM

Outset offers a turn key concierge medicine business model and training for private practitioners. With over 40 years of experience in the Health & Wellness industry, we have gathered insight from providers, patients, and office staff to create clinical programs that deliver real results and optimize efficiency for your practice. For more information on Outset visit OutsetHealth.com or contact us at 866-634-8560.

OxyHealth

Booth #6021

10719 Norwalk Blvd., Santa Fe Springs, California, 90670 | USA

Ph: (562) 906-8888

Email: information@oxyhealth.com www.oxyhealth.com

OxyHealth is the world’s leading provider of hyperbaric chambers. Presently, OxyHealth is the pioneer of the industry with over 15,000 chambers in use, more than all other providers combined. OxyHealth continues to remain at the forefront of superior performance, quality and cutting-edge design concepts that far exceed industry safety standards.

Pathways Bioscience Booth #3103

12635 E Montview Blvd,Suite 130 Aurora, Colorado, 80045 | USA

Ph: (720) 372-4815

Email: contact@pathwaysbio.com www.pathwaysbio.com

At Pathways Bioscience we believe that the human body is amazing and its systems are hard to improve upon. Therefore we believe the best way to extend healthspan and promote healthy aging is to support the body’s own, built-in defense mechanisms that allow it to protect and heal itself. Our focus is on the body’s NRF2 transcription factor, often referred to as the “master regulator” of protective genes, and our new NRF2-activating dietary supplement Grandevity.

PCCA Booth #6091

9901 S. Wilcrest Dr., Houston, Texas, 77099 | USA

Ph: (800) 331-2498

Email: emichael@pccarx.com www.pccarx.com

Are you looking to treat more patients, diversify revenue and achieve long-term growth? Joining PCCA’s community of compounding pharmacies could be your prescription for success. We give pharmacy teams the confidence to compound with instant access to over 9,000 up-to-date formulas, 24/7 connection to 20+ pharmacists dedicated to providing quick and thorough answers to your toughest questions and industryleading base technology to serve every patient need. Now with no upfront fee, it’s never been easier to join.

Pellecome LLC

Booth #3039

111 Canfield Ave,Ste. A-7

Randolph, New Jersey, 7869 | USA

Ph: (973) 714-9136

Email: melissa@pellecome.com www.pellecome.com

Pellecome is a medical company that introduced the Re3 Advanced Pellet Delivery System for Men and Women, a medical device kit that enables clinicians of any specialty to insert pellets easily and safely, every time. The kit includes an insertion tool with needle guide, precision scalpel and convenient needle filler. The Pellecome insertion device places pellets in a perfect line every time, providing consistent hormone absorption and minimizing patient discomfort and risk of pellet extrusion.

PEMF Systems, Inc.

Booth #8047

15131 Califa Street, Van Nuys, California, 91411 | USA

Ph: (702) 448-2660

Email: info@pemfsystems.com www.pemfsystems.com

“PEMF SYSTEMS, INC. manufactures the world’s most advanced Pulsed Electro-Magnetic Field therapy devices. Stop by our exhibit and you will see amazing improvements in pain and range of motion in people using our PEMF therapy device. Experience this therapy for free and you will know within five minutes if it makes an improvement for you.”

Pharmalink

Booth #8044

500 Westover Dr,#9480

Sanford, North Carolina, 27330 | USA

Ph: (888) 222-2671

Email: support@plprx.com www.plprx.com

PharmaLink is a nationwide provider of turnkey medication dispensing solutions that enable physicians and other medical professionals to dispense medications at the point of care rather than sending patients to a traditional pharmacy. Dispensing medications with PharmaLink creates a new revenue stream, increases patient medication compliance, and improves patient satisfaction by providing medications conveniently, confidentially, and cost effectively.

PharmaLink also offers standalone inventory management and medication compliance software.

Physician Compounding Alliance llc

Booth #9038

9319 Spring View Loop

Estero, Florida, 33928 | USA

Ph: (719) 201-9268

Email: twbader@aol.com www.PhysicianCompoundingAlliance.com

Clinic Dispensed BHRT improves practice income, therapeutic choices, and patient convenience. Discover how PCA’s turnkey program easily integrates BHRT Dispensing into any practice setting. Choose dosage forms and excipients best Suited for your patients. Reduce clinic time spent issuing prescriptions and authorizing refills.

Physicians Lab

Booth #1018

4850 T Rex Ave,Suite 150

Boca Raton, Florida, 33431 | USA

Ph: (877) 316-8686

Email: info@physicianslab.com www.PhysiciansLab.com

Physicians Lab was created to serve two purposes: providing state-of-the-art science and superior solutions. We provide state-of-the-art science to a growing number of physicians focused on integrative medicine and wellness for an aging population. We provide superior solutions to practices and patients who are actively seeking to manage their health through innovations in technology and preventive medicine. We deliver precise and reliable results while providing the tools necessary to complete convenient and affordable lab testing.

Physicians Preference Pharmacy

Booth #8090

20214 Braidwood Dr.,Suite 140

Katy, Texas, 77450 | USA

Ph: (281) 698-8626

Email: pharmacy@physicianspreferencerx.com www.physicianspreferencerx.com

Physicians Preference Pharmacy is a Houstonbased, PCAB-accredited compounding pharmacy. We are licensed to work with doctors and patients in 48 states (excludes NV, AL). With standards more stringent than those of the United States Pharmacopeia (USP), we rank first in Houston for the number of samples sent for potency testing and in the top 8% nationwide. With over 100 years of combined pharmacy experience, our pharmacists focus on increasing the health span of your patients.

Podcasting and Videos Made Easy

Booth #8021

16118 Caldera Ln., Naples, Florida, 34110 | USA

Ph: (248) 705-7893

Email: shawnsmith@themobilepro.net www.podcastingandvideosmadeeasy.com

Podcasting and Videos Made Easy trains you and your staff to create and launch a professional podcast & YouTube channel in only ONE weekend of in-person training. Through our in-person workshops, follow-up support, and access to our network of trusted partners, we equip providers to exponentially increase sales by marketing ALL services to their existing patient base and new patients alike. Bring your practice into the 21st century. Harness the power of online marketing.

Power2Practice

Booth #7039

2907 Butterfield Rd.,Suite 100 Oak Brook, Illinois, 60523 | USA

Ph: (312) 762-5804

Email: lmaloney@forumhealth.com www.power2practice.com

Power2Practice is specifically designed for functional and integrative medicine. With features such as customized note templates, cash-based billing module/superbills, specialty lab integrations, Fullscript interface, Power2Practice gives you all the EMR capabilities you expect, plus the specialized features you need. Our intuitive patient portal facilitates patient communication, online scheduling, appointment reminders and much more. Plus, with the addition of our newly released Televisit module, Power2Practice streamlines the efficiencies of the charting, front office and patient experience.

Precision Compounding Pharmacy

Booth #9026

2657 Merrick Rd., Bellmore, New York, 11710 | USA

Ph: (516) 833-6262

Email: compounding@precisionpharmacy.net www.precisioncompoundingpharmacy.net

Patients need to be recognized as individuals with different genetic makeups. Prescription regimens need to be viewed as unique protocols as specific as a fingerprint. With capabilities of customizing individual formulations, Precision Compounding Pharmacy makes it easy to individualize patient care. We pride ourselves on our high levels of communication, affordable compounded formulations, clinical consultations, and quick door to door deliveries.

Precision Point Diagnostics

Booth #6099

9 Dunwoody Park Ste # 122, Dunwoody, Georgia, 30338 | USA

Ph: (678) 736-6374

Email: info@precisionpointdiagnostics.com www.precisionpointdiagnostics.com

Precision Point Diagnostics is an innovator of testing solutions that assist in the diagnosis and management of conditions commonly addressed by Functional Medicine. Our unique profiles address comprehensive approaches to Patient care.

Prestige Products Direct Booth #

9043

12440 SW 117 Ct., Miami, Florida, 33186 | USA

Ph: (305) 234-8081

Email: triaddirect@gmail.com www.triadaer.com

Triad Aer. Professional Air Purification system

Prevencio, Inc.

Booth #9016

11335 NE 122nd Way, Kirkland, Washington, 98034 | USA

Ph: (619) 889-8539

Email: cpeters@prevenciomed.com www.prevenciomed.com

Prevencio offers highly accurate, novel AI-driven HART blood tests for cardiovascular disease developed in partnership with Massachusetts General Hospital (MGH). HART tests use Machine Learning + Multiple Proteins + Proprietary Algorithms to surpass accuracy of currently available cardiovascular tests. Two tests available for patients: • HART CVE™ –blood test for 1-year risk of heart attack, stroke or cardiac death; • HART CADhs™ – blood test for obstructive coronary artery disease diagnosis.

Prism Light Pad

Booth #6047

13303 E. Adams Aircraft Circle, Englewood, Colorado, 80112 | USA

Ph: (720) 664-4929

Email: info@prismlightpod.com www.prismlightpod.com

Prism Light Pod, the leader in innovative whole-body red light therapy solutions is pleased to offer the Prism Light Pad. Prism Light Pad is the industry’s most adaptable, portable and affordable full-body red light therapy solution measuring 72” x 36” with 2,200 660nm red and 850nm near-infrared LEDs to accelerate recovery, reduce inflammation, Increase collagen and more. The pad may be rolled up for easy storage and travel. Prism Light Pod’s advanced design, optimized setting and one-button operations found in our award winning light pods are incorporated into the Prism Light Pads which are designed and assembled in Denver, CO.

Prism Light Pod

Booth #5046

13303 E. Adams Aircraft Circle, Englewood, Colorado, 80112 | USA

Ph: (720) 664-4929

Email: info@prismlightpod.com www.prismlightpod.com

Prism Light Pod is the leading innovator of wholebody red light therapy systems for the wellness industry and winner of the 2020 and 2021 LuxLife Award for Best and Most Powerful Red Light Bed. Developed by a team of passionate health professionals and industrial engineers, Prism Light Pod, headquartered in Denver, CO, develops the most powerful, energy efficient and 100% automated/ optimized full-body, photobiomodulation systems in the industry that speeds recovery up to 10 times faster and distributes its products worldwide.

PRMEDICA, Inc.

Booth #2081

Transpeninsular Hwy KM 25,Plaza Esperanza San Jose Del Cabo, Baja California Sur, 23400 | Mexico

Ph: 52-624-688-8497

Email: info@prmedica-inc.com www.prmedica-inc.com

PRMEDICA is a British-based Corporation at the forefront of Biocellular Regenerative Medicine. Has developed new advanced protocols harnessing the power of mesenchymal stem cells and MSCderived exosomes to offer the latest and most advanced treatments in stem cell therapy. Their advanced LONGEVITY TREATMENT contains Stem Cells and Exosomes, including a Telomerase activator supplement, Stem Cell Booster implants, NAD+ supplements, and Hyperbaric Oxygen therapy to reverse the aging process and extend one`s health and life span by 20 years and more.

ProCBD by CV Sciences

Booth #3066

9530 Padgett Street,Suite 107 San Diego, California, 92126 | USA

Ph: (855) 758-7223

Email: shannon.thomas@cvsciences.com www.pluscbdoil.com/ProCBDinfo.html

CV Sciences creates practical health solutions to better promote everyday wellness. As a leader in the CBD industry and the first to bring hempderived CBD products to the consumer market, CV Sciences supports practitioners with exclusive product offerings, comprehensive training, and by spearheading legislation to pave the way for a robust legal CBD market. Brands include ProCBD, PlusCBD, and all-new The Reserve Collection.

Prodrome Sciences

Booth #3037

40880 County Center Drive, Ste R., Temecula, California, 92591 | USA

Ph: (951) 550-0505

Email: cs@prodrome.com www.prodrome.com

Prodrome Sciences is a specialty laboratory, supplement manufacturing and research company. Our products are the result of extensive scientific evidence from large clinical studies from around the world. We research and develop solutions to prevent disease, improve health and vitality, and achieve longevity.

Progressive Medical Booth #8032

10024 SE Sandpine Lane, Hobe Sound, Florida, 76634 | USA

Ph: (561) 379-6230

Email: carmine@medicalwaveus.com www.progressivemedicalusa.com

Progressive Medical is the leader in Storz, EPAT/ Shockwave technology. We specialize in providing preventative and anti-aging medical professionals the world’s most effective and advanced EPAT technology reporting a 91 % success rate according to clinical studies. Practices across the country utilize our technology to optimize their patient’s quality of life. We are committed to helping physicians in the fields of integrative, preventative, functional and regenerative medicine improve their patient outcomes while creating new revenue streams.

PromoItalia LLC

Booth #2049

1401 Brickell Ave.,Ste 550 Miami, Florida, 33131 | USA

Ph: (786) 360-3878

Email: sales.usa@webpromoitalia.com www.us.webpromoitalia.com

Promoitalia, an Italian company leader in the aesthetic medicine field, has the main goal to manufacture and sell advanced technology, methodology and consumable products, letting people to achieve their own beauty and wellness. The engine that drives company activity is the continuous pursuit of excellence, exclusive design and research.

Protocol For Life Balance

Booth

#8043

244 Knollwood Drive, Bloomingdale, Illinois, 60108 | USA

Ph: (877) 776-8610

Email: sales@protocolforlife.com www.protocolforlife.com

Protocol For Life Balance is a well-researched, potent, and efficacious brand of high-quality dietary supplements and natural products sold exclusively through licensed healthcare practitioners. Protocol For Life Balance offers many unique formulas and products, that come with a money -back guarantee if any patient is less than 100% satisfied. Our mission is simply to provide quality products that lead to healthy patients and satisfied physicians. Family Owned and Operated. www.protocolforlife.com 877-776-8610

PureWave Technologies

Booth #1024

1014 Gateway Blvd., Boynton Beach, Florida, 33426 | USA

Ph: (561) 965-7777

Email: toni@purewavenow.com www.PureWaveNow.com

PureWave Technologies is a leading provider of innovative bioenergetics wellness devices to help people manage stress, transform their health and live a happier, more productive life. We envision a world powered by pure clean energy that enhances the bioenergetics of the human body to restore energy deficiencies and to bring electromagnetic coherence to our environment, homes, workplace and planet.

Qest, LLC

Booth #6039

70 W Canyon Crest Road,100 Alpine, Utah, 84004 | USA

Ph: (385) 335-8514

Email: benjamin@qest4.com www.qest4.com

Qest is the world leader in Bioenergetic Technology. At Qest we pride ourselves in creating an environment that helps practitioners to create or build upon the success that they have in their clinics. We manufacture and sell the latest and greatest bioenegertic testing unit, QEST4. Our goal is to provide practitioners with equipment that will enable them to work with clients by focusing on primary and root cause issues instead of endlessly chasing symptoms.

Qualia by Neurohacker

Booth #1044

2011 Palomar Airport Rd.,,Suite 101 PBM 160

Carlsbad, California, 92011 | USA

Ph: (858) 243-5479

Email: support@neurohacker.com www.neurohacker.com

Neurohacker Collective was founded in 2015 with the mission to advance human quality of life by creating best-in-class well-being products. They employ a unique methodology for research and development based on complex systems science which focuses on supporting the body’s ability to self-regulate. The company began with a focus on cognitive products with the launch of Qualia Mind and has since developed products to support sleep, longevity, skin, energy, and vision. neurohacker.com

Quartermaster Tax Management, LLC

Booth #6100

805 Trade St. NW,Suite 101-A

Concord, North Carolina, 28027 | USA

Ph: (704) 490-4111

Email: info@quartermastertax.com www.quartermastertax.com

U.S. businesses qualify for the Research & Development tax credit. This credit is not only a reduction to current and future tax liabilities, but also a source of cash for you now. An expansive list of activities make businesses eligible, including activities that are technological in nature, intended to eliminate uncertainty, experimental in the sense that the activity is systematically trial and error, and performed with a purpose to improve performance and functionality.

Quest Cardiometabolic Center of Excellence

Booth #7090

500 Plaza Dr., Secaucus, New Jersey, 7094 | USA

Ph: (908) 692-5262

Email: Trisha.B.Winchester@questdiagnostics. com www.questdiagnostics.com

The Quest Cardiometabolic Center of Excellence is committed to advancing the prevention of the most costly and debilitating cardiovascular events. Our broadly available comprehensive menu of novel biomarkers spanning the cardiometabolic continuum provides deeper insights into hidden risk that go well beyond traditional testing.

Quicksilver Scientific

Booth #5021

1960 Cherry St, Louisville, Colorado, 80027 | USA

Ph: (303) 531-0861

Email: support@quicksilverscientific.com www.quicksilverscientific.com

Quicksilver Scientific’s proprietary delivery technology uses nanoliposomes and nanoemulsions to bypass normal absorption problems. As soon as the liquid hits your mouth, absorption into the bloodstream begins. Quicksilver Scientific’s products are clinically proven to rapidly deliver high concentrations of premium nutrients into your body for a difference you can feel.

Rapid Release Technology

Booth #2038

3303 Harbor Blvd.,Ste.D-10 Costa Mesa, California, 92626 | USA

Ph: (949) 415-4778

Email: calvin@rapidreleasetech.com www.rapidreleasetech.com

The Future of Pain Relief. High speed vibration therapy uses acoustic waves to precisely target fascia and connective tissue to provide physical and neurological effects for quick relief of aches, pains and restrictions. Short wavelength provides comfortable treatment for extremities, joints, knots, trigger points and restrictions. See why it is the favorite tool for over 30,000 health care professionals. Stop by for a quick session to release your stress and tension, leaving you refreshed, relaxed and pain free.

Refine USA

Booth #8046

340 3rd Ave South,Suite C

Jax Beach, Florida, 32250 | USA

Ph: (904) 240-4269

Email: support@refineusa.com www.refineusa.com

Refine USA, LLC located in Jacksonville, FL has been a market leader in the manufacturing and distribution of premier aesthetic technologies for more than 18 years. We pride ourselves on designing and developing medical devices that meet the clinical and financial needs of aesthetic health care providers. The FDA Cleared Rejuvapen NXT® Microneedling System, the PureSpin® PRP System

Regenative Labs

Booth #3084

1700 W Main St,Ste 500

Pensacola, Florida, 32502 | USA

Ph: (800) 891-3452

Email: info@regenativelabs.com www.regenativelabs.com

Regenative Labs’ mission is to facilitate predictable patient outcomes by providing the highest quality human tissue allografts available. With the goal of addressing the root cause rather than masking pain, Regenative Labs’ birth tissue allografts provide a nonaddictive, non-invasive option for patients. Our stateof-the-art production facility is in Pensacola, Florida. We spare no expense when it comes to the technology, we insist is necessary to produce the quality regenerative products we expect for our partners.

RegenLab USA

Booth #7084

1401 58th St. Brooklyn Army Terminal, Brooklyn, New York, 11220 | USA

Ph: (800) 220-9082

Email: info@regenlabusa.com www.regenlabusa.com

RegenLab offers FDA cleared products manufactured in the USA, with a focus on product quality, patient safety, and preparation efficiency. With over one million treatments provided worldwide, we are committed to the development of a unique expertise in the design and manufacturing of high-quality medical devices for the preparation of cellular therapies and autologous platelet-rich plasma (PRP).

Ph: (310) 798-2830

Email: sales@rejuvenation-science.com www.Rejuvenation-Science.com

Sophisticated supplements for integrative, regenerative and functional medicine practices begin with toprated Maximum Vitality multivitamin. Support brain health with nootropics and choline-bound omega-3s, endocannabinoid management for pain, inflammation, anxiety and sleep, mitochondrial and organ energy with metabolic optimizer protocol, including NAD+ Boost, cellular optimizer, mitochondrial biogenesis, and ubiquinol, and much more. Please chat with us to understand our quality, knowledge, integrity, and attention to individual clinicians.

Relax Saunas

3509 N. High St., Columbus, Ohio, 43214 | USA

Ph: (304) 541-7276

Email: relaxsaunamelissa@gmail.com

Relax Saunas are portable, affordable, personal use saunas with two 700 watt radiators that continuously emit Far Infrared Rays (FIR) while the sauna temperature may vary between 140-170 degrees Fahrenheit. Relax Saunas warm up instantly, and cause a detoxifying sweat within 20 minutes. Relax Saunas increase body temperature 3-4 degrees in 25-60 minutes which triggers a sequence of benefits including immune system stimulation, increased nitric oxide and decreased body inflammation.

Ph: (602) 316-1063

Email: drrobinsonnmd@protonmail.com www.relicusmedical.com

Relicus: Tomorrow Starts Today! A premier retail health acquisitions and holding company specializing in regenerative and longevity medicine. Relicus was created with a vision to build, acquire, develop and promote a vibrant and sophisticated nationwide network of medical practices and companies in the wellness, longevity, anti-aging, and age management medicine spheres in order to deliver seamless patient experiences, streamline operations, capture maximum market value, offer patients the latest scientific advances and produce massive equity.

Researched

Booth #6073

Nutritionals®

PO Box 224, Los Olivos, California, 93441 | USA

Ph: (805) 693-1802

Email: customerservice@ researchednutritionals.com www.researchednutritionals.com

Researched Nutritionals® is passionate about research because we know facts make all the difference. This is why we publish peer-reviewed clinical research on our industry-leading formulations. With products focused on key areas of health such as mitochondrial function, immune support, detoxification, and cytokine health, Researched Nutritionals® is a leader within the practitioner-exclusive dietary supplement market and is dedicated to working directly with healthcare practitioners for their most challenging patient needs.

Rupa Health

Booth #3021

177 Townsend St.,#528

San Francisco, California, 94107 | USA

Ph: (208) 422-4536

Email: koby@rupahealth.com www.rupahealth.com

Rupa Health is a platform for ordering functional medicine lab tests. Order, track, and get results from 30+ lab companies in one place. We also take patient support off your plate allowing you and your business to operate at maximum efficiency!

Revelation

Pharma Booth #8033

9777 Pyramid Court,Suite 230

Englewood, Colorado, 80112 | USA

Ph: (855) 434-6654

Email: info@revcustomrx.com www.revcustomrx.com

Revelation Pharma is a quality-driven and clinically based national network of sterile and non-sterile compounding pharmacies. Because we are trusted experts in the compounding industry, our existence is to educate providers about the proper role of compounded therapies while partnering together to help achieve the best patient care.

RGS Healthcare / Save Your Throid Booth #5100

450 S. Orange Ave.,Floor 3 Orlando, Florida, 32801 | USA

Ph: (407) 881-7791

Email: rudy@rgshealthcare.com www.rgshealthcare.com

RGS Healthcare is helping providers across the USA to save their patients thyroids by offering thyroid radiofrequency ablation. Thyroid RFA is a non-surgical alternative which preserves the thyroid function for enlarged sympotmatic benign nodules that are causing compressive symptoms.

Rx Harmony Booth #8078

45 Technology Pkwy S,Ste. 225 Peachtree Corners, Georgia, 30092 | USA

Ph: (770) 838-3570

Email: info@thejoigroup.com www.thejoigroup.com

As experts in health, we understand the challenges of running a medical practice. Whether by sustainable, revenue-generating programs or the collective buying power of partners, The JOI Group can help you master the business of wellness. Rx Harmony delivers a proven clinical model that provides patients a white-glove experience in-between office visits, eliminates the burden of prescription management for your team, and creates a predictable recurring revenue for the practice if you so choose.

SALT Chamber Inc.

Booth #8089

120 NW 11th Street, Boca Raton, Florida, 33432 | USA

Ph: (561) 286-8269

Email: jason@SALTChamberInc.com www.SALTChamberInc.com

SALT Chamber is “Leading the World in Salt Therapy Solutions™”. Celebrating our 10th anniversary, SALT Chamber is the pioneer and innovator in salt therapy room concepts and experiences, having designed, built, and installed over 1,400 worldwide projects for medical professionals, med spas, wellness centers, and health and fitness clubs. The first to develop the multi-purpose salt therapy concept, SALT Chamber has worked with many medical facilities to create stunning and effective salt rooms.

Sanesco

Booth #1048

2 Trident Dr., Arden, North Carolina, 28704 | USA

Ph: +1 (866) 670-5705`

Email: info@sanescohealth.com www.sanescohealth.com

Sanesco is a medical company specializing in improving quality of life through personalized medicine worldwide with innovative, research-driven, and evidence-based clinical tools and products for neuroendocrine health. Our NeuroWellness Program™ guides healthcare providers in addressing underlying causes of common health concerns such as anxiousness, low mood, fatigue, and sleep difficulties. Components of the NeuroWellness Program include: - Neuroendocrine testing - Personalized analysis report correlating symptoms and imbalances - Nondrug, Targeted Nutritional Therapy formulas

SaunaSpace

Booth #2085

1330 E. Prathersville Rd., Columbia, Montana, 65202 | USA

Ph: (573) 667-2862

Email: hello@sauna.space www.sauna.space

Rejuvenate at a cellular level with a sauna that harnesses the power of the sun. SaunaSpace combines cutting-edge infrared technology with nature’s ancient wisdom to help you find relief.

Sciton

Booth #5079

925 Commercial Street, Palo Alto, California, 94303 | USA

Ph: (650) 493-9155

Email: info@sciton.com www.sciton.com

Sciton is committed to providing best-in-class laser and light solutions for medical professionals who want superior durability, performance and value. Sciton offers best-in-class medical devices for laser-assisted lipolysis, fractional and full-coverage skin resurfacing, hair removal, phototherapy, wrinkle reduction, treatment of vascular and pigmented lesions, scar reduction and acne. For more information, and a complete list of Sciton systems, visit www.Sciton.com.

seca

Booth #7060

13601 Benson Avenue, Chino, California, 91710 | USA

Ph: (909) 223-4938

Email: bobby.ison@seca.com www.hubs.li/Q01p1ZJw0

We live in an era with advanced treatment options to delay age-related health issues and extend longevity and quality of life. Measuring progress is important for patients to see while they work to optimize their health. seca’s body composition devices allow you to individualize care, keep patients engaged, and motivate them continue their efforts long term. seca is committed to onboarding, clinical support, and efficient cloud-based reporting. Contribute to longer, better lives with seca medical body composition to support success.

See Beyond Medicine

Booth #3061

2 Overhill Rd.,Ste. 260 Scarsdale, New York, 10583 | USA

Ph: (914) 722-9440

Email: info@seebeyondmedicine.com www.seebeyondmedicine.com

We strive to see you clearly. We see you holistically. We discover your body and mind through genetics and bio-makers. We see you beyond your age, weight, and chronic illness. We see your potential and possibility for a healthy future. SeeBeyond™ Medicine offers cutting-edge Functional Medicine Testing to discover your “root cause” of your disease. Our doctors are board-certified in Functional Medicine, Integrative Family Medicine, and Obesity Medicine. We are here to solve your problem.

Selphyl PRP/PRFm

Booth #1040

940 Town Center Drive, Langhorne, Pennsylvania, 19047 | USA

Ph: (480) 664-9490

Email: ryan@skintechsystems.com www.selphyl.com

PLATELET-RICH FIBRIN MATRIX (PRFM) NEXT GENERATION PRP The Selphyl® System is designed for the safe and rapid preparation of PRFm from a small sample of blood at the patient point of care. Many PRP systems require operator skill, have varying results and have extensive contamination with red blood cells and white blood cells. PRP is converted to PRFm through a controlled process, creating a fibrin scaffold that serves to protect and preserve platelets.

SilverCeuticals Inc.

Booth #7064

1396 W. 200 South, Ste.2C, Lindon, Utah, 84042 | USA

Ph: (385) 212-4044

Email: sales@silverceuticals.com www.silverceuticals.com

SilverCeuticals is dedicated to providing the latest Silver Nano-Particle Technology to the world. This technology is available in many types of products (immune support products, cosmetics, wound care, etc.). It will make you change the way you do health.

Sinclair Booth #6042

1239 Broadway #1103, New York, New York, 10001 | USA

Ph: (888) 415-1192

Email: donna.jin@sinclair.com www.vioramed.com

Formerly known as Viora, a market leader in advanced medical aesthetic research, development and manufacturing. With a presence in more than 65 countries, Sinclair’s non-invasive products address a wide range of solutions, treating today’s most commonly requested applications used in anti-aging, body & facial contouring, cellulite reduction, acne clearance, hair removal and more.

Skin Type Solutions

Booth #3090

7257 NE 4th Ave, Miami, Florida, 33138 | USA

Ph: (305) 714-5322

Email: info@skintypesolutions.com www.sellmoreskincare.com

Sell more skin care with your own e-commerce store. Fulfillment: Orders are fulfilled and shipped directly to your customers from our warehouse. Inventory: Access to 35+ medical skin care brands with no minimum order (In-office inventory optional). Retention: Customer Loyalty rewards and email marketing created by Skin Type Solutions. Support: Customer care, training, and client support. Technology: Scientific skin care recommendation software created by a Dermatologist.

Booth #4093

46 Regency Plaza, Glen Mills, Pennsylvania, 19382 | USA

Ph: (610) 680-7676

Email: office@smartgraft.com www.SmartGraft.com

Vision Medical is a leading USA manufacturer that develops and markets medical and aesthetic products for the medical and aesthetic markets for worldwide distribution. SmartGraft® FUE Hair Restoration System, with closed canister system for storage, keeps harvested grafts chilled, hydrated and robust without exposure to outside air. This allows for rapid harvest, optimal graft preservation and significant reduction in harvesting times, SmartGraft allows donor grafts the best possible chance of regrowth for better patient outcome.

195 Chastain Meadows Ct,Suite 109 Kennesaw, Georgia, 30144 | USA

Ph: (801) 376-9423

Email: Sales@joinsoftwave.com www.JoinSoftwave.com

SoftWave TRT is a medical technology company that is developing advanced solutions specializing in shock wave therapy for better patient healing.

Sofwave Booth #3064

1211

Ph: (815) 540-9221

Email: brittany.edmondson@sofwave.com www.sofwave.com

Sofwave™ breakthrough, non-invasive Synchronous Ultrasound Parallel Beam Technology SUPERB™ FDA-cleared to lift the eyebrow, lift submental tissue, improve facial lines and wrinkles

SmartGraft by Vision Medical, Inc.

SottoPelle

Booth #2075

8412 E. Shea Blvd., Ste. 101, Scottsdale, Arizona, 85260 | USA

Ph: (323) 986-5100

Email: response@sphrt.com www.sottopelletherapy.com

SottoPelle® is a renowned international pellet training company dedicated to improving the quality of life for women and men as they age. The late, Dr. Gino Tutera MD, FACOG, Founder of SottoPelle®, was the premier doctor who revolutionized the HRT world by pioneering bio-identical hormonal pellet therapy. Our Services go beyond providing physicians with training. We develop long-term relationships built on trust, and continue building out a company with professionalism as the gold standard.

SRW Laboratories

Booth #1050

L2, 111 Carlton Core Rd Newmarket, Auckland, Auckland, 1141 | New Zealand

Ph: (642) 172-0892

Email: hello@srw.co www.srw.co

SRW Laboratories is a global premium health and wellness brand with high quality and trusted products with sustainability promises. SRW offers a holistic range of nutraceuticals that support your health at a cellular level as you age. We partner with leading global researchers to curate the very latest in science and research to bring you formulations that help you age well.

Standard Process

Booth #8027

1200 W. Royal Lee Dr., Palmyra, Wisconsin, 53156 | USA

Ph: (800) 848-5061

Email: education@standardprocess.com www.standardprocess.com

Standard Process has been a leader in whole food nutritional supplements for more than 90 years. We cultivate raw ingredients from seed to soil to supplement — the great majority of which are grown on our certified organic farm. We create high-quality products that advance health and change lives.

Stellar Biomolecular Research

Booth #4086

Edenkoben, Edenkoben, Rheinland-Pfalz, 67480 | Germany

Ph: (608) 844-8989

Email: siti@nxg-global.com www.sbi-europe.com

SBR engages manufacturing consultants, biochemist and biomolecular research therapists to innovate a diverse array of healthcare and aesthetic products and services for consumers who seek alternative regenerative solutions against premature aging and debilitating chronic diseases through their brand MF Plus and LAB RMS.

Strive Compounding Pharmacy

Booth #2045

1275 E. Baseline Rd.,Ste.104 Gilbert, Arizona, 85233 | USA

Ph: (480) 626-4366

Email: info@strivepharmacy.com www.strivepharmacy.com

Strive Compounding Pharmacy is a sterile and nonsterile compounding pharmacy. With our state of the art facility we house a sterile cleanroom suite and multiple non-sterile compounding labs. We have gone above and beyond to ensure our quality remains un touched. We specialize in Hormone Replacement, Weight loss, Veterinary, Thyroid, Pain Management, Dermatology, Erectile Dysfunction, and much more.”

Symphony Natural Health Booth #8080

2550 S. Decker Lake Blvd Ste # 28, West Valley City, Utah, 84119 | USA

Ph: (415) 243-9991

Email: customer.service@symphonynaturalhealth.com www.symphonynaturalhealthpro.com

Symphony Natural Health, a vertically integrated natural products company controlling every step from seed to shelf, starting with organic, sustainable farming practices, developing proprietary manufacturing processes individual to each herb, concentrating full spectrum of active ingredients while maximizing bioavailability, through to our own GMP, Kosher, organically certified encapsulation, packaging and fulfillment operation ensuring the highest quality product. We engage in our own research including pharmacology, toxicology and doubleblind, placebo-controlled clinical trials all published in peer-reviewed, International medical journals.

TA Sciences

Booth #5007

420 Lexington Ave.,#2900

New York, New York, 10170 | USA

Ph: (212) 588-8805

Email: info@tasciences.com www.tasciences.com

T.A. Sciences® was founded in New York City by Noel Thomas Patton in 2002. T.A. Sciences® is dedicated to creating research-based, clinically tested products that help address telomere shortening through Telomerase Activation. T.A. Sciences® is widely recognized as the leader in the field of Telomere Biology. T.A. Sciences® spends over $1 million each year on leading edge scientific research, including doubleblind, placebo-controlled studies proving the safety and effectiveness of its premiere product TA-65®.

Tailor Made Compounding

Booth #4064

200 Moore Drive, Nicholasville, Kentucky, 40256 | USA

Ph: (859) 887-0013

Email: support@tailormadecompounding.com www.tailormadecompounding.com

The Tailor Made Difference. A Higher Standard of Care. As experts in compounded medications, we provide custom wellness solutions to satisfy the unique needs of all types of patients. Our individualized treatments not only yield better health results - but maintain them for years to come. Visit us at www.tailormadecompounding.com to learn more about our integrative care treatments!

Tatt2Away by Rejuvatek Medical Inc.

Booth #1058

8160 Highland Dr.,Bldg A, Ste # 2 Sandy, Utah, 84093 | USA

Ph: (855) 252-2929

Email: removals@tatt2away.com www.tatt2away.com

Tatt2Away is the organic solution for a natural, safe, and effective pigment removal service. Tatt2Away strives to become the most accessible international tattoo and pigment removal service on the market for customers and businesses alike. Tatt2Away fosters close relationships with medical spas and doctors offices, who utilize our technology to serve their customers with efficient and trustworthy results.

Texas Star Pharmacy

Booth #2093

3033 W Parker Rd,Ste 100

Plano, Texas, 75023 | USA

Ph: (972) 519-8475

Email: pharmacist@texasstarpharmacy.com www.texasstarpharmacy.com

Texas Star Pharmacy is built on one philosophy; that our patients’ health and well-being are our primary focus. We are committed to delivering the best quality solutions at the best possible cost. We work directly with providers through our compounding pharmacy to create innovative medications suited for your needs. We adapt and evolve to stay leaders in the industry through innovation, customization, and collaboration. Some of our focus areas are IV and wellness, anti-aging, weight management, men’s, and women’s health.

The Functional Medicine Project

Booth #3045

587 Orchard Street, Ashland, Oregon, 97520 | USA

Ph: (541) 299-3999

Email: support@functionalmedicineproject.org www.functionalmedicinceproject.org

The Functional Medicine Project offers a turnkey solution for providers to help and empower their patients to turn their health around using researchbased Functional (root-cause) Medicine principles and practices. Partner with patients for a 9-Week Total Health Reset, supporting them through the education, structure, experience, and guidance they need to make and sustain major health and lifestyle changes that affect chronic illness, symptoms and/or longevity. Clinician guidance and mentoring accompanies the Program if needed.

The Institute of Regenerative Medicine Booth #5091

200 Glades Rd, Boca Raton, Florida, 33432 | USA

Ph: (954) 993-4567

Email: npeterson@stcell.com www.stcell.com

The Institute of Regenerative Medicine provides physician and clinician trainings on highly sought after regenerative medicine treatments and protocols. Trainees are taught by industry pioneer, Joseph R. Purita, MD and his expert staff of specialists either in his modern clinic or in yours. Treatment supplies and support are provided in perpetuity. Learn hands-on how to do EBO2, the most advanced ozone therapy on the market, as well as autologous cell therapy and other biologic modalities.

Thera Wellness Solutions, Inc.

Booth #8104

10411 Motor City Drive Ste 615,St. 615 Bethesda, Maryland, 20817 | USA

Ph: (240) 442-1919

Email: office@therawellness.us www.therawellness.us

THERA WELLNESS SOLUTIONS, LLC is a premier provider of clinically proven holistic wellness technology products. At the heart of THERA WELLNESS solutions is the THERA WELLNESS device that helps you support your clients’ wellbeing with non-invasive healing energy therapy that delivers results in just a few sessions. Discover the applications for sensitivities, physical discomforts, stress management, and emotional balancing... over 900 applications to help your clients with highly personalized, targeted therapies.

THOR Photomedicine

Booth #6043

8375 Jumpers Hole Road,Suite 110 Millersville, Maryland, 21108 | USA

Ph: +1 877 355 3151

Email: mark.granic@thorlaser.com www.novothor.com

THOR Photobiomodulation (PBM) is an alternative to opioid pain relief. We’re revolutionizing pain management and injury recovery using red and nearinfrared light. PBM, when applied to pathologies, is absorbed in mitochondria, triggering regenerative and anti-inflammatory processes. Our customers include Navy Special Warfare, US Special Forces, Navy Seals, and professional sports teams. THOR collaborates with world-class institutions including the VA, Harvard Medical School, They love our technology because PBM relieves pain and helps people heal.

Thrivv LLC Booth #6061

3805 OLD EASTON ROAD #305, Doylestown, Pennsylvania, 18902 | USA

Ph: (877) 676-8875

Email: amy@wethrivv.com www.wethrivv.com

WETHRIVV™ is more than a company with products in aesthetics and beauty. We focus on hair growth and facial aesthetic products. REVIVV® For Him and For Her are natural hair growth serums with real results backed by clinical data. Mask_d® is a 2-step process to post procedure care focusing on face masks and serums. We are innovators comprised of a team of individuals with diverse backgrounds that span science, technology, marketing, training and product development.

Timeline Nutrition

Booth #1039

1160 Battery Street East,Suite 100 San Francisco, California, 94111 | USA

Ph: (888) 631-3359

Email: care@timelinenutrition.com www.timelinenutrition.com

Timeline Nutrition is pioneering a new class of nutritional products backed by cutting edge science and designed to target the biological pathways that prolong healthspan. Timeline, based at the EPFL in Switzerland, launched the postbiotic Mitopure™, the first nutrient that triggers a well-conserved anti-aging pathway in the human body, improving cellular bioenergetics and increasing muscle strength and endurance. Mitopure’s the innovative heart of a suite of groundbreaking convenient and delicious products. See our clinical trials and learn more at www.timelinenutrition.com

Trocar Supplies

Booth #9025

126 Nulf Drive, Columbiana, Ohio, 44408 | USA

Ph: (740) 314-9959

Email: brandon@trocarsupplies.com www.trocarsupplies.com

Trocar Supplies, a family-owned business, is the pioneer and worldwide standard for the disposable trocar medical kit industry. We take great pride in offering an affordable price for the highest quality products. Through patient feedback and researchbased treatment, our trocar kits have been the optimal way to treat hormone deficiencies for over fifteen years. The utilization of our disposable trocar kits are the most efficient method and safest product for hormonal replacement therapy.

Troscriptions

Booth #4102

19888 Church St., Rehoboth Beach, Delaware, 19971 | USA

Ph: (925) 558-2717

Email: admin@snhlife.com www.troscriptions.com

Pioneered by Dr. Ted Achacoso, Troscriptions (Tx) is a line of precision dosed, pharmaceutical grade, and physician formulated buccal troches for cognition, calm, pain, sleep, and more. A portion of Tx proceeds goes to supporting our nonprofit Health Optimization Medicine and Practice (HOMe/HOPe), the first and only multi-omics specialty that defines and delivers the standard of care for health, not disease

Nutrition-Based Solutions for Promoting Optimal Health

Consuming functional foods can be a convenient way to add highly nutritious and bioactive ingredients to the diet.w The Dynamic product line contains powdered formulas that transform into delicious drinks rich in superfoods and vital nutrients.w The targeted ingredients promote healthy inflammatory markers in supporting optimal immune, gut, heart, and endocrine function.w

Health benefits may include:

• Promoting GI health.w • Supporting healthy immune functionw • Supporting cardiovascular and cardio-metabolic health.w • Promoting healthy detoxificationw • Supporting healthy endocrine functionw • Promoting healthy skin, strong bones, and flexible jointsw

To learn more, visit: nutridyn.com/functional-foods

TruDiagnostics

Booth #7094

881 Corporate Drive, Lexington, Kentucky, 40503 | USA

Ph: (859) 797-2983

Email: ryan@trudiagnostic.com www.trudiagnostic.com

TruDiagnostic is a leading health data company with a focus on multi-omics and insights gained from the fluid epigenome. Established in early 2020, after development and build out of its 10,000 square ft state of the art laboratory with Illumina equipment and consultation it launched its first physician and patient test “TruAge”. Today, TruDiagnostic has built a premiere epigenetic database of DNA Methylation markers and covariates which is one of the largest in the world.

Uberlube

Booth #2071

7316 Ridgeway, Skokie, Illinois, 60076 | USA

Ph: (888) 391-8082

Email: med@uberlube.com www.uberlube.com

Uberlube Luxury Lubricant is designed to enhance intimacy. Always slippery, never sticky. There is no reason to experience painful sex. Uberlube may be just what you are looking for. Not harmful to healthy bacteria or pH levels Physician recommended, used in OB-GYN practices Cruelty free without animal products and vegan friendly No alcohol, no gluten, no glycerin, no parabens, no scents and flavors Latex safe but not recommended for use with silicone Made in USA

Ulta Lab Tests

You Order the Test. We’ll Do the Rest!

Ulta Lab Tests

Booth #3036

9237 E. Via De Ventura,Ste. 220 Scottsdale, Arizona, 85258 | USA

Ph: (480) 681-4081

Email: johnroehm@ultalabtests.com www.Ultalabtests.com

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University Compounding Pharmacy

Booth #4013

1875 3rd Ave., San Diego, California, 92101 | USA

Ph: 800-985-8065 x 5700

Email: dave@ucprx.com www.ucprx.com

UNIVERSITY COMPOUNDING PHARMACY (UCP)

a nationally recognized leader in drug and device therapies. For 27 years our expert Pharmacists and experienced Physician Liaison team have been dedicated to support an unbiased product line, devising the management of BHRT conditions for your patients. We meet FDA & BOP prescription requirements and dispense in nearly 50 states.

COMPOUNDED: THYROIDS, ESTROGENS, PDE-5 INHIBITORS- BIOIDENTICAL HORMONES.

Uriel Pharmacy

Booth #3060

N8464 Sterman Rd., East Troy, Wisconsin, 53120 | USA

Ph: (866) 642-2858

Email: orders@urielpharmacy.com www.shopuriel.com

Uriel’s path to better health: Health is as dynamic and individual as each person’s body, life story and destiny. The human body has been formed from cosmic forces and earthly substances. Uriel works with those forces and substances to create natural remedies that help restore health. Uriel makes natural homeopathic and anthroposophic remedies by potentizing substances from the mineral, plant and animal kingdoms and skin care products that promote good health and longevity.

Ulta Lab Tests provides deep discounts on laboratory testing services to healthcare professionals and a free practice management solution. We provide the medical director for non-scriptwriting healthcare practitioners. We used the combined purchasing power of our network’s 23,500 healthcare professionals to negotiate incredibly low prices, which we then pass on to our partners and their patients. We provide a free personalized microsite for healthcare professionals and their patients/clients to order lab tests online 24/7.

US Biotek Labs

Booth #6037

16020 Linden Ave. N., Shoreline, Washington, 98133 | USA

Ph: (206) 365-1256

Email: bharris@usbiotek.com www.usbiotek.com

US BioTek Laboratories is an industry-leading international laboratory that pioneers testing methods that deliver quality results with the highest degree of reproducibility. US BioTek provides the most comprehensive food sensitivity and inhalant testing and the most convenient collection method for organic acids and environmental pollutants tests utilizing dried urine.

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Vertisis Custom Pharmacy

Booth #7100

9343 E. Bahia Drive,Suite 200 Scottsdale, Arizona, 85260 | USA

Ph: (303) 476-3447

Email: matthewb@vertisis.com www.vertisis.com

Vertisis is one of the most unique sterile-injectable compounding pharmacies in the United States. Our focus is on going “above and beyond” traditional compounding pharmacies by raising the standards of 503A compounding pharmacies to include exceptional products, unique delivery, advanced education, and an amazing relationship with health care providers with a seamless delivery of care. We are Vertisis Custom Pharmacy, your custom compounding pharmacy for integrative and naturopathic IV therapies and compounds.

Vibrant Wellness

Booth #8038

1021 Howard Avenue,Ste B San Carlos, California, 94070 | USA

Ph: (913) 638-3106

Email: events@vibrant-wellness.com www.vibrant-wellness.com

Vibrant Wellness is a leading biotech company based in San Carlos, CA, delivering life-transforming lab testing that enables health and wellness providers to discover the root of patient health issues. We’re at the forefront of modern medicine and research, providing personalized health analytics using cutting-edge, high-quality technology. We believe that anyone can achieve better health and vibrant longevity through individualized solutions based on testing—not guessing.

. H . R . E . A .

Viola Threads

Booth #7048

315 N Puente St,Suite H Brea, California, 92821 | USA

Ph: (213) 351-0001

Email: info@violathreads.com www.violathreads.com

Booth #7049

20285 Stewart Crescent,Unit 303 Maple Ridge, British Columbia, V2X 8G1 | Canada

Ph: (800) 490-1738

Email: christine@naturoaid.com www.vitaaid.com

With 20+ years of experience in the natural health industry, Vita Aid Professional Therapeutics strives to provide high-quality and effective nutraceuticals for health care practitioners worldwide. We focus on products for professional, safe, and effective therapeutic use and follow strict pharmaceuticalgrade standards. What differentiate Vita Aid from others are: • Exclusive to health care practitioners

• Clinical evidence based formulations • No added stearic lubricants – for higher bioavailability of active ingredients • Vegetarian formulas

VitalRemedyMD Inc.

Booth #3094

Ph: (561) 347-6446

Email: info@vitalremedymd.com www.vitalremedymd.com

Since over 20 years one of the US leading Premium Nutritional Supplement companies supporting healthy aging for body & mind.

Vitelle Labs

Ph: (877) 902-2332

Email: liz@vitellelab.net www.VitelleLab.com

197 ANTI-AGING MEDICAL NEWS | WINTER 2022

Vivos Therapeutics

Booth #7093

7921 South Park Plaza,Suite 210 Littleton, Colorado, 80120 | USA

Ph: (816) 853-8667

Email: ndegennaro@vivoslife.com www.vivoslife.com

More than one billion people suffer from mild-tomoderate obstructive sleep apnea. The Vivos Method is a proprietary multidisciplinary treatment protocol often combined with cost-effective oral appliance technology to treat dentofacial abnormalities and/or mild-to-moderate OSA and snoring. The Vivos Method offers an all-natural, non-surgical, non-pharmaceutical, and pain free approach.

Ward Photonics Booth #2032

1980 N. Atlantic Ave,Suite 1008

Cocoa Beach, Florida, 32931 | USA

Ph: (800) 392-5950

Email: marketing@wardphotonics.com www.Wardphotonics.com

Since earning our first FDA–Clearance in 2015, Ward Photonics has strived to provide superior service and support for our providers and their patients. With our devices, UltraSlim® and UltraSmooth®, we are pioneers in the use of photobiomodulation for noninvasive, aesthetic treatment. With the use of our patented technology, we are able to provide unparalleled transformations of the face, neck, and body, without the need for invasive procedures.

Wavi Medical Booth #1066

3459 Ringsby Ct., Ste.305, Denver, Colorado, 80216 | USA

Ph: (720) 773-9284

Email: marketing@wavimed.com www.WAVimed.com

WAVi: A complex system made simple. The WAVi platform consists of patented, FDA-cleared hardware with an extremely user-friendly headset. The headset design was made out of materials created by the founder of Crocs Footwear. This is paired with software to evoke and analyze the brain’s electric response. WAVi is fast (principal test is just 4-min), portable (can be conducted in an office, home or school), affordable and user-friendly. Reporting is immediate with personalized, actionable reports.

Wellness Clinic Marketing

Booth #7043

1470 Biscayne Blvd, Miami, Florida, 33132 | USA

Ph: (800) 401-7046

Email: info@wellnessclinicmarketing.com www.wellnessclinicmarketing.com

Based in South Florida, our company provides patient acquisition marketing services to medical wellness practices offering cash-based medical treatments to men & women looking to improve their well-being through hormone optimization, medical weight loss, and aesthetic procedures. Over the past ten years, we’ve developed a proven and tested strategy for a medical wellness practice to generate new patients. Combined with our proprietary PatientFlow Acceleration Program, our marketing program generates high-quality leads and cash-paying patients for our medical clients.

Wellness Pharmacy

Booth #1036

3401 Independence Dr.,Ste.231 Birmingham, Alabama, 35209 | USA

Ph: (800) 227-2627

Email: georgia@wellnesspharmacy.com www.wellnesspharmacy.com

With over 55 years of compounding experience, Wellness Pharmacy is considered the industry leader in quality and customer service. Our specialties include chelation, bioidentical hormones, autism support, and preservative-free injectables. Wellness Pharmacy is also the only pharmacy to successfully patent the preparation of injectable glutathione. PCAB-accredited.

Well ProZ

Booth #8036

1021 Howard Ave,Suite B San Carlos, California, 94070 | USA

Ph: (866) 364-0963

Email: hello@wellproz.com www.wellproz.com

Well ProZ is a customizable, plug-and-play e-commerce platform for health and wellness professionals. Well ProZ makes it easy to grow your practice, reduce staff workload, and improve patient care—no coding required. Personalize your shop to match your brand, then stock it with products from our vast library of premium precision lab tests, professional-grade supplements, and consultation services. We handle shipping, fulfillment, and logistics so you can reach patients nationwide.

Ward Photonics

WholeScripts

Booth #1055

6800 Kingspointe Parkway, Orlando, Florida, 32819 | USA

Ph: (800) 647-6100

Email: info@wholescripts.com www.wholescripts.com

WholeScripts is a digital dispensary of choice and the only place where exclusive XYMOGEN formulas can be ordered. It is also an integrative medicine platform and tool that supports healthcare practitioners in helping patients achieve and maintain their optimal health. WholeScripts is a subsidiary of XYMOGEN, a family-owned health science company that has been manufacturing and distributing highquality dietary supplements for over 30 years.

Women’s Hormone Network. Inc. Booth #9055

PO Box 50512, Santa Barbara, California, 93150 | USA

Ph: (888) 614-1044

Email: info@womenshormonenetwork.org www.womenshormonenetwork.org

WHN is a registered 501(c)3 not-for-profit corporation to promote, advocate, and advance women’s wellbeing and longevity through clinical research and education about the benefits of Physiologic Restoration to reduce the symptoms of hormone imbalance and degenerative decline.

World Insurance Associates Booth #2046

100 Wood Ave. South, 4th floor, Iselin, New Jersey, 8830 | USA

Ph: (805) 300-8239

Email: ethorson@thorsonins.com www.worldinsurance.com

World Insurance Associates is a unique insurance organization offering top products and services from major providers, combined with attentive service from local agents. Founded in 2011, World is the second fastest-growing insurance broker in the U.S. We specialize in personal and commercial insurance lines, surety and bonding, employee benefits, financial and retirement services, and human capital management solutions.

Xtend-Life Group Limited

Booth #1060

12 Mary Muller Dr., Christchurch, Canterbury, 8022 | New Zealand

Ph: +64 3 384 2116

Email: customer.service@xtend-life.com www.xtend-life.com

Xtend-Life is a 100% New Zealand owned business with the mission to provide people the foundation for better health. We manufacture a range of supplements, skincare and superfoods using only the highest quality natural ingredients with strict adherence to quality. Xtend-Life has successfully operated globally since 2000. Tens of thousands of people from around the world have been helped in their quest to delay the effects of ageing and to feel and look their best.

Y LIFT

Booth #4047

2 E 61st St.,Suite 413 New York, New York, 10065 | USA

Ph: (212) 861-7787

Email: jasonp@ylift.com www.ylift.com

Y LIFT is a leading medical technology and training company empowering medical professionals with a comprehensive online portal that provides a central place to shop, learn, teach, and engage from anywhere in the world. Y LIFT has developed cutting edge minimally invasive procedures such as the renowned Y LIFT, SurgYlift, and MagnYm and offers Live and online training via the Y LIFT portal.

Young Goose

Booth #1063

18800 NE 29th Ave.,Ste # 619

Aventura, Florida, 33180 | USA

Ph: (407) 729-3423

Email: service@younggoose.com www.younggoose.com

Young Goose is the world’s first biohacking skincare. Our products aim to elevate the skins NAD+ levels, and activate age-reversing genes (Sirtuins), to stop and reverse signs of aging.

Zimmer MedizinSystems

Booth #7099

Suite B, Irvine, California, 92618 | USA

Ph: (800) 327-3576

Email: info@zimmerusa.com www.ZimmerUSA.com

Zimmer MedizinSystems in Irvine, California, with its parent company in Neu-Ulm, Germany, has over 50 years of expertise in manufacturing high quality medical devices. Zimmer MedizinSystems’ flagship products, Z Wave and our Cryo family of devices, utilize advanced Radial Pulse Therapy and Cryo Therapy technologies. The company has set the gold standard for Cryotherapy and skin cooling systems and is introducing the new Cryo 7 and the new water-cooled and ultra-quiet Z Wave Q.

Zion Healing Inc.

Booth #3085

368 East Riverside Dr,#8 UT, Utah, 84790 | USA

Ph: (801) 674-2628

Email: robert@zionhealing.com www.zionhealing.com

Zion Healing grants franchises to operate clinics for the treatment of Mental Health and Substance Use Disorders for Youth and Adults to be located generally in regional cities in the United States. The Franchise provides services for the treatment of chronic depression, anxiety, addiction, substance abuse and mental health issues under the name Zion Healing. Zion Healing utilizes proprietary educational systems (LMS) and equipment including; Neurofeedback (QEEG brain mapping), and Transcranial Magnetic Stimulation (TMS).

Zizion

Zizion Inc.

Booth #5085

141 NW 20th Street,Suite G1

Boca Raton, Florida, 33431 | USA

Ph: (561) 221-1000

Email: bruce@zizion.com www.Zizion.com

Zizion Group is a medical distribution company with a focus on natural integrative therapies. We bring technologically advanced products, targeted training, and innovative marketing expertise, to empower physicians to expand their practice. We are an endto-end provider, identifying appropriate solutions and deployment methodologies while working with your team to ensure success. You are never considered a customer; you are a valued physician partner.

ZRT Laboratory

Booth #7007

8605 SW Creekside Pl, Beaverton, Oregon, 97008 | USA

Ph: (503) 466-2445

Email: info@zrtlab.com www.zrtlab.com

ZRT laboratory, a CLIA-certified commercial and research laboratory, is the recognized leader in innovative and meaningful hormone and wellness testing. ZRT has pioneered testing methods for hormones, neurotransmitters, heavy metals and more, offering health care professionals convenient testing options in different body fluids including saliva, dried blood spot, dried urine, and serum. ZRT provides comprehensive test results that allow providers to create personalized treatments for optimal outcomes, with the help of our knowledgeable clinical consultants.

PLASMALOGEN SUPPLEMENTS

Restore the lipid of life.

“ We have been deploying plasmalogen precursors at the Regenesis Project and have found that within the timef rame of a few weeks, people have become more alert and cognizant ”

-Sheldon Jordan, MD, FAAN, DABPN, DABCN, Medical Director, the Regenesis Project

Plasmalogens are depleted with age and disease. There are no effective dietary sources.

Plasmalogens restore and enhance the function of neurons, muscles, and white matter to improve cognition and mobility and reduce inflammation.

Don’t risk your life and vitality with insufficient plasmalogens.

. Goodenowe is an invited speaker e 30th Annual A4M World Congress. Discover the Recipe for Longevity - it’s all in your brain! Don’t miss his Saturday, December 10th presentation.

We hope to see you there!

nd your life r. Go at the Discover mis Foun

ounder and CEO, Prodrome Sciences Dayan Goodenowe, PhD

ZRT is the Leader in Saliva Testing

ZRT is one of the first labs to measure hormones in saliva, and helped establish the method that made saliva hormone testing commercially viable for health care providers and patients around the globe.

Today’s Most Advanced Saliva Testing

Ranges Adjusted for Supplementation

Unlike other labs, patients do not need to stop hormone supplementation to use ZRT’s testing because we have ranges adjusted for age, menstrual status and supplementation types. This is the ideal method for tracking the effectiveness of hormone treatments.

Extraction

ZRT is the only lab to perform an extraction process for saliva testing, which separates hormones from background contamination. This is the only way to assure accurate test results for low-concentration hormones such as estradiol.

Setting Industry Standards

ZRT initiated and manages the industry-wide Saliva Proficiency Inter-laboratory Testing Program (“SPIT”) – which enables laboratories to regularly evaluate and improve saliva testing accuracy.