MEMORY ALTERATION

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MEMORYALTERATION

PreetPandit

ResearchScholarsProgram,HarvardStudentAgencies.IncollaborationwithLearnwithLeaders

ABSTRACT

Inmedia,manypeopleviewmemory-alteringtechnologiesassciencefictionorusedformanipulativereasons,buttheirimpactsandimplementationsaredeeperthan that.Whenwefacetraumaticexperiencesandevents,ourbraintakesalongtimetorecover Therearemanydifferentsideeffectsandcopingmechanismswhichare stillbeingresearchedandobserved.Someofthesesideeffectsgoasfarasunintentionallyalteringyourmemory Dependingontheseverity,itcouldreducenormal braincapacityandactivity Ifweweretoalterthememoriesofsaidtraumaticevent,itwouldserveasdamagecontrolandpossiblyreversesomeofthedestructiveand negativeinfluencesitcouldhaveonourbrains.

KEYWORDS:Memory-altering,PTSD,amygdala,hippocampus,prefrontalcortex,neurogenesis.

INTRODUCTION

When a person faces traumatic events, their brain usually represses memories that significantly reduces brain capacity and activity Neuroscientists have researchedanddiscoveredthattherearemanyreasonsastowhyourbrainisn't abletoprocesstheseeventsandwhyourmemorycanbeoneofthecasualtiesofit (Brito,2019).Therehavebeenmanysolutions,liketherapy However,noteveryone would find therapy beneficial due to the differences in their situations and personalities.Thisraisesthequestion:ifourbraincanunintentionallyalterour memories,whycan'tweintentionallydoittohelpus?

Materials&Methods

Ÿ Primary:underprimaryresearch,Aneurologisthasbeeninterviewedfora more professional opinion on memory alteration and its applications in thefuture.

Ÿ Secondary:Scholarlyarticlesaboutthebrainanditsfunctionswereconsulted.Informationwasobtainedthroughsecondarysourcesbutwasdiscussedandevaluatedthroughprimarysources.

BackgroundInformation

1. Whydoesourbrainaltermemories?

Ourbrainislikeaprocessor,itprocessesinformationandmemoriesand storesvaluablemomentsandpiecesofdata.Whenthis“processor”faces anunfamiliarobstacle(traumaticeventofsomesort)itglitchesandcannotcomprehendwhat'shappening.Asaresult,ourbraintendstounintentionallyalterourmemoriesregardingthatspecificeventwhichmay havecausedharmtoyouorfrightenedyou.Whythishappenscouldbe formanyreasonsstillbeingstudied,suchasanimpulseorareactionis similartotheflightorfightreaction.Itcouldalsosimplybeone'sbrain tryingtoprotectthemfromsaidtrauma.

When Cortisol and other stress hormones likeAdrenaline significantly increase due to traumatic events, it harms specific regions of our brain liketheprefrontalcortex,hippocampusandamygdala(Arnsten,2009).

2. Understandingthebrain

Virtually,weuseourentirebrainonadailybasistofunctionandconduct dailytasks.Justlikeeverything,ourbrainisalsoapartofasystemandis asystemitself.Evenifonepartweretofail,itwouldbeveryhardforthe restofthebraintocopeandadjust.Therearethreemainareaswhichget influenced by PTSD; the amygdala (processing of negative emotions), thehippocampus(“memorycenter”)andtheprefrontalcortex(cognitive functions)(QueenslandBrainInstitute,n.d.).

Amygdala: The amygdala is a small almond-shaped organ located underthehemispheresofourbrain.Itisinchargeofprocessingnegative emotions and activating the flight or fight response.The fight or flight responseisactivatedwhenourbrainsensesdanger;it'sactivatedtoprotectusandprepareustoeitherfightorflee.Theamygdalaalsohasapart inmemoryasitstoresmemorieswhichsupportorcontainnegativeemotionssuchasfear(Guy-Evans,2023).

Thehippocampus: hippocampus intricatebrainsystemwhich islocatedinthetemporallobe.Itisassociatedwithmemoryandlearning asitisinvolvedinstoringlong-termmemory Thehippocampusissupposedly responsible for making these memories resistant to forgetting butthatisafunctionwhichisarguedupon.Ifanyharmisinflictedupon thehippocampus,itcancauseamnesia,whichcausesyoutoforgetmemoriesandpreventyoufrommakingnewones(Spanòetal.,2020).

According to research, our hippocampus can shrink due to excessive stress.Thiscanpotentiallybereversedandrepairedwiththehelpofactivatingneurogenesisandneuroplasticity(EunJooetal,2015;Bremner, 2006).

PrefrontalCortex:Thepre-frontalcortexhasabigroleincognitiveand control functions. It also controls some hormones like dopamine, controls prospective memory and is a place where short-term memory is stored(EunJooetal,2015).

3. WhatisNeurogenesis?

Neurogenesis can be described as the creation of new neurons. Many studies have shown that neurogenesis can help improve learning capabilitiesandmemoryrecollectionasitstimulatesthehippocampus(Klein et al., 2017). Neurogenesis can be stimulated by aerobic exercises and learningnewthings;thiscouldhelpimprovememoryrecollection(Sukyuetal.,2015).

Thepurposeofthispaperistoanswerthefollowing:

Ÿ Ismemoryalterationpossible?

Ÿ Whatistherelationbetweenemotionandmemory?

4. Differenttypesofmemories.

Thereare4maintypesofmemories(Kleinetal.,2020).

Copyright©2023,IERJ.Thisopen-accessarticleispublishedunderthetermsoftheCreativeCommonsAttribution-NonCommercial4.0InternationalLicensewhichpermitsShare(copyandredistributethematerialinany mediumorformat)andAdapt(remix,transform,andbuilduponthematerial)undertheAttribution-NonCommercialterms.

Research Paper Psychology E-ISSN No : 2454-9916 | Volume : 9 | Issue : 3 | Mar 2023
17 InternationalEducation&ResearchJournal[IERJ]

Short-termMemory

LongTermMemory

Short-termmemoryisremembering acertainamountofinformationin smallintervalsoftime(usually seconds)

Long-termmemorystoresspecific piecesofinformationofaneventfor longperiodsoftime.Itcanalsotake importantpiecesofinformation fromshort-termmemoryandcreate long-lastingmemoriesfromthem

WorkingMemory

SensoryMemory

Research&Findings

TraumaandMemory,What'sthelink?

Whenyouareworkingonatask, workingmemoryiswhenyou remembersomethingrelatedtowhat youarefocusingon.

Sensorymemorycomesfromthe fivesensoryfeelings;sound,feel, smell,sight,andtaste.Sensory memorieslastafewsecondsandthe leastandfocusonyourabilityto process,understandandrecallwhat youseeandtheenvironmentaround you.

Weknowthatourhippocampuscanshrink;thisiscausedduetoexcessivestress causedbyavarietyofreasons.Studiesshowthatglobally,72%ofpeoplearefacing stress (Patterson, 2022). Even though there may be many reasons for this stress,themajorityofitisusuallycausedbytrauma,andtheymaybesuffering fromPTSD(post-traumaticstressdisorder).5outofevery100adultssufferfrom PTSD(U.S.DepartmentofVeteranAffairs,2023),andgiventhesestatistics,we cancometoaconsensusthatbecauseofPTSD,wecanloseourmemory

One common but very destructive coping mechanism for mental illnesses like PTSDisdenial.Manypeopleliveindenialtorunawayfromthetrauma;thisis knownasmemoryrepression.Whentraumaistoomuchortooseveretohandle, peoplerepressordisassociatethemselvesfromthespecificmemory Thisisone ofthemaincausesofmemoryloss(Hanson-Baiden,2022).Inadditiontothat, researchershavediscoveredthatyoucandevelopPTSDbecauseofrepressinga memory and that you don't have to remember the traumatic memory itself to develop severe cases of PTSD. Memory repression is a defense mechanism to protectyourbrainfromharm,it'ssimilartothepurposeoftheamygdalainthe brainexceptmemoryrepressionisawaytodetachyourselfandrunaway Thisis harmfulformanyreasons,foroneitcausesmemoryloss,butitalsohasharmful symptoms which you wouldn't be able to notice because of living in constant denialandfearofacceptance.Anotherharmfulimpactisthatifthismemoryis somehowtriggeredinthefuture,itcouldhavedevastatingimpactsonnotonly yourmentalhealthbutalsoyourphysicalhealth,dependingontheseverityofthe reaction.

Asdiscussed,PTSDisveryharmfultoourbrains.PTSDcanleadtobraindamageandobstaclesinbraindevelopmentandgrowth. TheproblemisPTSDbut howdowecopewithit?Theworldhashadmanydifferentsolutionstowardsthis problem.Aslowbutprogressiveoneistherapy Addictiveanddestructive'solutions'includedrugsandalcohol.Eventhoughtherapyhasbeenusedastheprimarytreatment(perhapstheonlytreatment)forPTSDandothermentalillnesses foralongtime,itdoesnotnecessarilyworkforallpatients.Therapyisslowandit takes time, and despite its 75% success rate (Parekh & Givon, 2019), it's not applicable to everyone. Therapy is everyone's first option because there aren't anymore,butwhatifmemoryalterationcouldbeone?

MemoryAlteration is much faster in comparison to therapy and it could yield moredefinitiveresults.Wejustneedtofigureouthowwecanapplyit.Another coping Mechanism for PTSD and other mental illnesses is our brain inadvertentlyalteringourmemoriestoprotectourselves,it'shealthierincomparisonto repressingthememories,butstillharmful.Researchshowsthattheemotionswe are feeling during an event can influence the memory of the event (Hermans, 2014).IfourAmygdalagetsoverloadedwithnegativeemotions,doesthismean thatthoseemotionscaninfluencethatmemory?Accordingtostudies,whenwe get emotional, our amygdala secretes adrenaline which helps us remember events or things that happened or occurred in that specific time period more clearlyandsharper(Wendt&Begum,2022).So,inasituationwhereadrenaline is secreted and you remember a very traumatic event at a rate which is much clearerthanyournormalmemory,wouldyourbrainautomaticallyalterittoprotectyou?Thismaybeautomatic,ornatural.Theamygdalaprocessesmainlynegative emotions. Some intense emotions such as anger, fear or even sadness are sometimesthecauseofmemorylossastheycouldleadtostress,thiscouldcause anoverloadofemotionsfortheamygdalaandleadtoactualalterationornatural erasureofsomeemotionswhicharelinkedtospecificallyintensenegativeemotions.Withthesefindings,wecanarriveatoneviablepoint:ifourbraincanalter

memorieswithoutusknowing,thatmeansthatwecantoo.Weonlyneedtofigureouthowto,andhowtocontrolit.

Discussion

Interviewsnippetwithneurologist“DrAshutoshShetty”

AccordingtoDrShetty,“Memorycanbealtered,it'spossible.Memoryisprocessedfromthevisualandverbalstimuluswhichgetsencodedinyourbrainand ifyougetpropersleep,itgetsstoredinoneofthememoryareastherearemany environmental factors which help in encoding and storing memory Memory encodingisdependentonyourstorageandyourattentionspan.Ifyourattention spanisgood,thenshort-termmemorycanbemanipulatedbutifyourencodingor retrieval storage is good, then, long-term memory can be more easily manipulated. MemoryAlterationas a treatmentfor PTSD depends on what symptoms theyarefacing,ifit'smorebehavioral,thenitwon'thelpthatmuchbutit'llhelp themwithdealingwithstressdisorders”.

Memorycanbealtered.However,toreachthatpoint,weneedtounderstandhow memoryisencoded,andhowwecanhackit.Whenweformanewmemory,the informationisdirectedtowardsthehippocampus.Inthehippocampus,itlinksall therelativepartsofinformationandcreatesanewmemorybycreatingnewsynapses. There are 3 types of memory encoding; Visual,Acoustic and Semantic. Thestrengthofthatmemoryisdependentonenvironmentalfactorsandwhether ourshort-termmemoryorlong-termmemoryisstronger

Morals&Ethics

Alltechnologycanbemisusedandabused.Ifmemoryalterationtechnologyis furtherdeveloped,itispossiblethatitcouldbemanipulatedormisused.Toprevent this, it should be used for therapeutic purposes only (treating mental illnesses).Isitethicallycorrecttoaltermemories?Ifapatientisunwillingtoalter theirmemories,thenitisunethicalbutifapatientgivesconsent,thistechnology wouldonlybeusedformedicinalpurposes.

Thistechnologycanhelpvictimsoftraumaandmentalillnessesdealwiththeir emotionalbaggageinaquickermannerwithmoreeffectiveresults.Depending on their symptoms and severity, the different types of memory can be altered (short/long-termmemories).

Conclusion

Wecanconcludewithtwomaintakeaways;1)memoryalterationispossible2)it canbeusedtotreatPTSDandothermentalillnessesdependingonthesymptoms faced. Although it can't completely reverse the behavioral damage which has alreadybeencausedbythetrauma,itcanhelpdealwiththestressandnegative emotionsandfeelingscausedbythetrauma. WiththislinkbetweenPTSDand memory, we can see causation and correlation between these variables. Even thoughtheinfluencescan'tcompletelybechanged,Memoryalterationasatreatmentwouldbemuchmoreefficientthanourbrain'sowncopingmechanismsfor dealingwithtrauma;Memoryrepressionwouldbemuchquickerthanoneofthe onlytreatmentswecurrentlyhaveavailable;therapy Sinceouremotionsinfluenceourmemories,iftherewasasituationwhereapersonwasfeelingnegative emotionsduetoaspecificeventwhichoccurredinashortperiodoftime,wecan figure out how to automatically alter memories based on set conditions.Anythingwhichcanbecodedcanbehacked.Wearestillfarfromdevelopingtechnologieslikethisfortreatments,but,thisinformationitselfissubstantialenough totryandfigureoutmoreaboutmemorystorageandhowourbrainfunctions.We already know that stress and memory are related and to an extent of stress, it couldnegativelyaffectmemory However,thelinkbetweenthosetwoconcepts itsmoreimportantandthelink,orsolution,mayaswellbeMemoryAlteration.

REFERENCES

1. Saussereau,Elodie,etal.“MemoryImpairmentafterDrug-FacilitatedCrimes.”Toxicological Aspects of Drug-Facilitated Crimes, 2014, pp 121–138, wwwsciencedirect com/topics/neuroscience/short-term-memory, 10 1016/b978-012-416748-3.00005-0.Accessed1Dec.2022.

2. Jennifer “WhattoKnowaboutLong-TermMemoryandLong-TermMemoryLoss.” Medicalnewstoday com, Medical News Today, 13 Oct 2021, w w w m e d i c a l n e w s t o d a y c o m / a r t i c l e s / l o n g - t e r mm e mory#:~:text=Long%2Dterm%20memory%20refers%20to,an%20indefinite%20perio d%20of%20time.Accessed1Dec.2022.

3. Ellen.“WhatIsWorkingMemory?”MGHClayCenterforYoungHealthyMinds,11 Sept. 2018, www.mghclaycenter.org/parenting-concerns/what-is-working-memory/. Accessed1Dec.2022.

4. ay,MichaelT.,andJohnNowicki.“GinkgoBiloba(GinkgoTree).”TextbookofNatural Medicine, 2020, pp. 620-628.e2, www.sciencedirect.com/topics/medicine-andd e n t i s t r y / p r e f r o n t a lc o rtex#:~:text=The%20prefrontal%20cortex%20(PFC)%20plays,prospective%20mem ory%2C%20and%20cognitive%20flexibility, 10.1016/b978-0-323-43044-9.000820.Accessed1Dec.2022.

5. https://wwwfacebook com/WebMD “What Are Sensory Memory Examples?” WebMD, WebMD, 21 May 2021, wwwwebmd com/brain/what-are-sensorym e m o r ye x a mples#: :text=Sensory%20memories%20are%20stored%20for,in%20your%20short %2Dterm%20memory Accessed1Dec.2022.

Research Paper E-ISSN No : 2454-9916 | Volume : 9 | Issue : 3 | Mar 2023
18 InternationalEducation&ResearchJournal[IERJ]

6. ErnoJ.,etal.“HowtheAmygdalaAffectsEmotionalMemorybyAlteringBrainNetwork Properties.” Neurobiology of Learning and Memory, vol. 112, July 2014, pp. 2

1 6 , pubmed.ncbi.nlm.nih.gov/24583373/#:~:text=The%20amygdala%20has%20long% 20been,anterior%20medial%20temporal%20lobe%20region, 10.1016/j.nlm.2014.02.005.Accessed1Dec.2022.

7. " R e p r e s s e d M e m o r i e s : 5 F a q s " H e a l t h l i n e , 2 0 2 3 , https://wwwhealthline com/health/repressed-memories#controversy Accessed 22 Feb2023.

8. Arnsten,AmyF T "StressSignallingPathwaysThatImpairPrefrontalCortexStructureAndFunction".NatureReviewsNeuroscience,vol10,no.6,2009,pp.410-422. Springer ScienceAnd Business Media LLC, doi:10.1038/nrn2648.Accessed 22 Feb 2023.

9. "Where Are Memories Stored In The Brain?" Qbi Uq Edu Au, 2016, https://qbi uq edu au/brain-basics/memory/where-are-memoriesstored#:~:text=Short%2Dterm%20working%20memory%20relies%20most%20hea vily%20on%20the%20prefrontal%20cortex.Accessed22Feb2023.

10. Bremner,J.Douglas."TraumaticStress:EffectsOnTheBrain".DialoguesInClinical Neuroscience, vol 8, no 4, 2006, pp 445-461 Informa UK Limited, doi:10.31887/dcns.2006.8.4/jbremner Accessed22Feb2023.

11. Guy-Evans, Olivia. "Amygdala Function And Location - Simply Psychology". SimplypsychologyOrg, 2023, https://wwwsimplypsychologyorg/amygdala html Accessed22Feb2023.

12. "Dreaming With Hippocampal Damage | Elife" Elifesciences Org, 2023, https://elifesciences.org/articles/56211#:~:text=Damage%20to%20the%20hippocam pus%20can,memories%20and%20remembering%20past%20experiences. Accessed 22Feb2023.

13. Goffredina Spanò, Gloria Pizzamiglio, Cornelia McCormick, IanAClark, Sara De Felice, Thomas D Miller, Jamie O Edgin, Clive R Rosenthal, Eleanor A Maguire (2020) Dreaming with hippocampal damage eLife 9:e56211 Available at: https://doi.org/10.7554/eLife.56211.

14. Kim,EunJooetal."StressEffectsOnTheHippocampus:ACriticalReview".Learning&Amp;Memory,vol22,no.9,2015,pp.411-416.ColdSpringHarborLaboratory, doi:10.1101/lm.037291.114.Accessed22Feb2023.)

15. Klein,C.etal."StimulationOfAdultHippocampalNeurogenesisByPhysicalExerciseAndEnrichedEnvironmentIsDisturbedInACADASILMouseModel".Scientific Reports, vol 7, no. 1, 2017. Springer Science And Business Media LLC, doi:10.1038/srep45372.Accessed22Feb2023.

16. Yau, Suk-yu et al. "Involvement OfAdult Hippocampal Neurogenesis In Learning And Forgetting". Neural Plasticity, vol 2015, 2015, pp. 1-13. Hindawi Limited, doi:10.1155/2015/717958.Accessed22Feb2023.

17. "Types Of Memory: Learn More About The Different Types Of Memory Here". Medicalnewstoday.Com, 2023, https://www.medicalnewstoday.com/articles/typesof-memory Accessed22Feb2023.

18. "Important Facts And Statistics About Stress: Prevalence, Impact, & More". The R e c o v e r y Vi l l a g e D r u g A n d A l c o h o l R e h a b , 2 0 2 3 , https://www therecoveryvillage com/mental-health/stress/stresss t a t i stics/#:~:text=About%2033%20percent%20of%20people,that%20impacts%20their% 20mental%20health.Accessed22Feb2023.

19. " VA G o v | Ve t e r a n s A f f a i r s " P t s d Va G o v , 2 0 2 3 , https://www.ptsd.va.gov/understand/common/common_adults.asp#:~:text=About% 205%20out%20of%20every,some%20point%20in%20their%20life Accessed 22 Feb2023.

20. Joelle Hanson-Baiden, BSc "The Debate On Repressed Memories" NewsMedical.Net,2022,https://www.news-medical.net/health/The-Debate-on-RepressedMemories.aspx#:~:text=Repressed%20memories%20are%20memories%20that,late r%2C%20often%20from%20a%20trigger Accessed22Feb2023

21. Parekh,R.,Givon,L.(2019)Whatispsychotherapy?(nodate)Psychiatry.org-What is Psychotherapy? Available at: https://www psychiatry org/patientsf a m ilies/psychotherapy#:~:text=About%2075%20percent%20of%20people,show%20so me%20benefit%20from%20it.&text=Psychotherapy%20has%20been%20shown%2 0to,in%20the%20brain%20and%20body (Accessed:February22,2023

22. Hermans,ErnoJ.,etal.“HowtheAmygdalaAffectsEmotionalMemorybyAltering Brain Network Properties.” Neurobiology of Learning and Memory, vol. 112, July 2 0 1 4 , p p 2 – 1 6 , pubmed.ncbi.nlm.nih.gov/24583373/#:~:text=The%20amygdala%20has%20long% 20been,anterior%20medial%20temporal%20lobe%20region, 10.1016/j.nlm.2014.02.005.Accessed1Dec.2022.

23. " A m y g d a l a : W h a t T o K n o w " W e b m d , 2 0 2 3 , h t t p s : / / w w w w e b m d c o m / b r a i n / a m y g d a l a - w h a t - t oknow#:~:text=The%20amygdala%20determines%20how%20we,Recognize%20and %20process%20emotions.Accessed22Feb2023.

19 InternationalEducation&ResearchJournal[IERJ] Research Paper E-ISSN No : 2454-9916 | Volume : 9 | Issue : 3 | Mar 2023

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