Laboratory buildings have at least twice the carbon footprint than their share of campus floor suggests they should. In addition, laboratory building operations require striking a careful balance of safety considerations with financial and carbon costs in a rapidly changing setting. This presentation will review major components of the environmental footprint of labs including: energy use, the building design process, and hazardous materials considerations. A variety of techniques for approaching these issues will be discussed, including behavior change campaigns, how the LEED system works in a lab setting, and working with facility and safety professionals to re- and retro- commission building operations.