NBT May 2011 by Paul Howells

www.nutraceuticalmag.com

Volume 7 Number 3

May/June 2011

Functional Ingredients Omega-3 phospholipids, chia seeds and soluble fibre

Brain Health Tocotrienols and neuroprotection

The NBT Awards A celebration of innovation

Healthier Foods Healthier People Healthier Business

Vitafoods Europe and Finished Products Expo

A powerful platform •

ingredients • functional foods • nutraceuticals • supplements • raw materials •

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contents

Volume7 Issue3

May/June2011Contents

06 Guest Editorial 04 Vitafoods Europe and Finished Products Expo

Europeâ&#x20AC;&#x2122;s leading dietary supplements event

Hanna Leerink

Vitafoods Conference 06 From Functional Foods to Gut Health and Immunity Julie Longton

NBT Awards 22 A Celebration of Food Innovation Charlotte Hodgson

GOED Report 30 New Work on a Codex Standard for Marine Oils Adam Ismail and Harry Rice

Legal Issues 32 Protecting Your Products From Being Copied Abroad Steve P. Hassid and Sophia Sarwar

Opinion 34 Healthier Foods, Healthier People, Healthier Business

46 The Facts Behind the Fibre

Last Word

Emily Lauwaert

78 China: Driving Global Growth in the Health Food Market

Brain Health 50 Bioenhanced Natural Palm Tocotrienol Complex and its Role in Neuroprotection Sharon Ling

Health Management

Sarah Medina

Congress Report 82 Lutein and its Benefits in Eye health: A Congress Charlotte Hodgson

56 Tobacco Withdrawal: An Innovative Nutritional Support Concept Alain Baniel and Harmony Villemin

Peter WennstrĂśm

Functional Ingredients 36 The Power of Omega-3 Phospholipids Henrik Traaholt

38 Chia Seed: The New Omega-3 Powerhouse

60 Superfruits: The Power of Polyphenols John H. Maher

Technology 64 Rapid Analytical Testing of Nutraceutical Compounds Anne E. Mack and William J. Long

Angela Dorsey-Kockler

Event Preview

40 The Heart of the Matter

68 NutrEvent: The Future of Nutrition and Health

Karin Wrzesinski

Etienne Vervaecke

May/June 2011 www.nutraceuticalmag.com

event preview

Vitafoods Europe and Finished Products Expo

The most powerful nutraceuticals platform in the industry.

eading industry shows — Vitafoods Europe and Finished Products Expo — return to Geneva (10–12 May) for what is set to be their biggest installment to date. With the market for functional foods, drinks, nutraceuticals and dietary supplements expanding at an uncontrollable rate — and expected to reach $243 billion in the next 4 years — there couldn’t be a better time for the events to take place. Last year, they broke all previous records with more than 8500 attendees passing through the doors of Vitafoods Europe and more than 2500 visiting Finished Products Expo. The show organizers plan to build on that success in the 2011 edition, as Event Director, Chris Lee, explains: “Each year we work hard to come up with new, creative and innovative ideas to improve on the previous year’s shows. From seeking brand new exhibitors who can bring something unique to the table to sourcing exciting educational features that can better help industry professionals, our aim is to bring something new that will exceed everyone’s expectations.” With rising healthcare costs, more consumers seeking healthier lifestyles and increasing scientific evidence supporting the benefits of health foods, the nutraceutical market continues to boom. The exhibitions will, together, play host to more than 500 Vitafoods Europe and 100 FPE suppliers of

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dietary supplements, functional foods and drinks and raw materials, plus leading laboratories, industry associations and publishing houses. Exhibitors set to showcase their latest innovations include international brands such as DSM, Croda Europe, Glanbia Nutritionals, NOW International and Nutribio, and other players including Algaecal Inc., Bioiberica SA, Go Caps and Select Botanicals.

More Than Just an Exhibition Running alongside the exhibition, the Vitafoods Europe Conference has built an international reputation within the nutraceuticals industry as a high quality conference delivering a programme that covers the hottest topics and themes in food ingredients. Organized by Leatherhead Food Research, the conference attracts some of the leading industry figures to share their latest discoveries, and is tailored to meet the needs of an ever-changing industry. Topics for 2011 include functional foods, chaired by Matthew Incles from Leatherhead Food Research, with a session from Intermed Discovery GmbH; appetite control, with Dr Jeff Brunstrom from the University of Bristol and Unilever; immunity and gut health with representatives from the Institute of Food Research and Plant and Food Research; physical performance

event preview

delivered by the English Institute of Sport, GlaxoSmithKline and the University of Stirling. Martek Bioscience will discuss mental health whereas DSM and Good Food Practice will debate heart health. The free-to-attend Vitafoods Discussion Forum will be chaired once again by Simon Pettman from EAS and will build on the exceptional debate at Vitafoods Europe 2010, where more than 250 participants witnessed a snapshot of the implications of the claims regulation for business. In 2011, it will provide a countdown of the biggest opportunities and challenges facing the functional food and supplement industries as they look forward to the next decade. The Discussion Forum will be chosen, rated and explained by a panel of multidisciplinary experts including Bas Van Buijtenen of DSM, Henry Dixon of BDB and Patrick Coppens of EAS. A large audience is expected and participants have the opportunity to send their questions for the panellists in advance by emailing forum@eas.eu. EAS will also be offering free one-on-one sessions from its experts, meaning visitors can benefit from sessions tailored to any aspect of their business including regulations, strategy, labelling and claims. Also joining this year’s compelling educational line-up will be Vitafoods Europe Supplier Seminar Theatre, sponsored by NATUREX (Stand 840). Always a popular attraction, this free-to-attend feature is crammed full of new products, developments and discoveries. Exhibitors will demonstrate their latest innovations to a captive audience whilst customers benefit from seeing the product in action. Innovation will be the central theme at the Vitafoods Europe New Products Zone, sponsored by NOW International (Stand 2010). Companies with innovative new market launches are eligible to enter their products for display in the feature, which is located at the show entrance. Always a hive of activity, it is a valuable tool in helping visitors to decide which stand to visit first. Meanwhile, VitaTrend will bring together the latest exciting trends and themes on nutraceuticals and functional foods in

two daily presentations to visitors from an Innova Market Insight expert along with an interactive tour of the exhibition floor to see these trends in action. New to the show this year will be The Nutraceutical Business & Technology Awards (NBTAs), which recognize excellence in R&D, marketing, business and technology in the areas of ingredients, finished products, applications and business practices. The associated business roundtable will feature some of the world’s major health, nutrition and wellness companies in a lively debate about overcoming the barriers to commercial success. Panellists will discuss the trials and tribulations of getting consumers to adopt and accept functional food and drink products. The intention is to deliver a set of benchmarks that will provide a global audience of nutraceutical professionals with the opportunity to recognize significant developments in quality of service, health management, R&D and relationship management, and will also provide a recognized and tangible reward for the successful companies. Equally, Finished Products Expo has an array of exciting features to attract a whole host of visitors. The Tasting Bar @ FPE, sponsored by Laboratoire PYC (Stand 2120) offers a unique opportunity to sample the latest innovations in the functional food and drinks market and establish the next big product to hit the industry. Likewise, the New Products Zone sponsored by NOW International will also showcase revolutionary developments launched during the last 12 months.

For more information Hanna Leerink IIR Exhibitions Tel. +44 203 377 3111 hleerink@iirx.co.uk www.vitafoods.eu.com/www.finishedproductsexpo.com www.vitafoods.eu.com/linkedin/www.finishedproductsexpo.com/linkedin

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guest editorial

From Functional Foods to Gut Health and Immunity This year’s Vitafoods Europe Conference examines the secrets behind the science.

ttempting to make gut health claims that relate specifically to the immune system is one of the most challenging areas of science currently faced by the industry. In response to its significance, this topic will be the focus of the first day of the Vitafoods Europe Conference, which will see leading scientists present frontline research on the latest developments in the field.

The Power of Kiwifruit Examining the specific changes in the composition and activity of the gastrointestinal microflora brought about by the consumption of kiwifruit will be Juliet Ansell from Plant & Food Research in New Zealand. This research is a world exclusive to Vitafoods and will report on the role of kiwifruit in promoting immune tolerance (good immunity) rather than inflammation (bad immunity) through a gut-mediated mechanism. By understanding the changes undergone by kiwifruit through digestion, carbohydrate chemical analysis, microbiology and mucosal immunology/morphology, it has been possible to postulate some of these potential mechanisms of action. The carbohydrate chemistry is essential to understand the mechanism of prebiotic action via carbohydrate degradation by the microbes. The research described in this presentation has also established that the consumption of whole kiwifruit generates changes in gut micromorphology and functionality by enhancing the growth and/ or metabolism of commensal/beneficial bacteria. These bacterialdependent components — independently to and/or concomitantly with digestible kiwifruit components, specifically carbohydrates — serve to enhance innate immunity at the mucosal gut surface. The hypothesis offered is that the role of kiwifruit, through a gut-mediated mechanism,

Consumer Trends Drive Product Innovation Natural, functional ingredients, supported by scientific evidence linking health and diet, are currently exhibiting the fastest growing consumer demand in the food industry. Capitalizing on the strengths of pharmaceutical R&D approaches, the gap between market needs and the innovation capabilities of the industry can now be bridged. The increasing number of consumers demanding ‘all natural’ products has caused the search for new functional food ingredients derived from natural products to be a key area of interest to many food and cosmetics companies. As a result of this, the industry must innovate, and do so quickly, or risk being left behind. The systematic identification of natural analogues based on edible source material not only has the potential to tailor product properties in terms of efficacy, costs and successful realization, but also allows for the solid protection of intellectual property rights. There are many publications that describe the pharmacological or physiological activities of natural product sources such as fruit, vegetables, fungi or other plants. These activities, however, can no longer be the subject of a patent claim. Although certain technological patents on processes may be applied, these are in fact much weaker than a specific use patent that concerns a particular application, compound and usage for a defined plant species.

Growth Opportunities One of many companies now driving innovation in the food and cosmetic industries is InterMed Discovery. With its roots in the pharmaceutical industry, it is able to utilize its knowledge of natural products, its access to reference samples and existing biological source data to select new activities for both new and well-known ingredients and protect those products using IP filings. Therefore, it is now possible to find new plants that deliver sought after effects such as satiety, slimming or immunostimulants. In its employment of IMB Bioprofiling, the company has been able to deliver new patentable functions, even for established food plants, including pure compounds as active ingredients. Indeed, InterMed Discovery has managed to outlicense 19 products in the last 5 years, demonstrating the growth potential of the natural functional ingredients market. Greater depth of analysis of the functional food market will be presented by Matthew Incles of Leatherhead Food Research and Dr Thoman Henkel of Intermed Discovery on the morning of 10 May at Vitafoods 2011.

www.nutraceuticalmag.com May/June 2011

strap

might be in ‘priming’ rather than ‘activating’ the immune response to promote good immunity rather than inflammation.

Microfloral Heath Recent research has resulted in the accumulation of a valuable understanding of markers that indicate a balanced colonic ecosystem. The human gut microflora, particularly the gut microbiota, play a key role in human health and will be the subject of a presentation by Helene Alexiou from Beneo. Gut microflora, particularly in the colon, play host to bacteria that can significantly influence aspects of human health through their secondary metabolism. They may, for instance, deconjugate substances intended for excretion, thereby making them once more available to the body or, more usefully, produce vitamins or antimicrobial substances that inhibit harmful bacteria. Combined with the colonic microflora’s possible interaction with the body’s gut epithelium or compounds of the immune system, the gut flora demonstrate great potential to display either inflammatory of immune defence effects. Indeed, although most colonic bacteria are not considered to be pathogenic or toxigenic, some may become so in a state of gut impairment. Our knowledge about the composition of the gut microflora has considerably improved during recent decades as a result of the advances in methods to quantify it. Whereas the 1980s saw the common use of plating methods, the molecular methodologies used today allow more precise quantification of those bacteria that cannot be cultured, a number of which appear to represent an important proportion of faecal bacteria. Thus, the importance of state-of-the-art techniques such as FISH (fluorescence in situ hybridization) or PCR (polymerase chain reaction) cannot be overestimated. Helene’s presentation will focus on work designed to stimulate a balanced and healthy gut microflora using a unique nutritional concept, comprising a refined concept of ‘healthy’ microflora and prebiotic inulin-type fructans. She will conclude by investigating how best to manage the transition to communicating healthy gut flora benefits and safety to consumers.

Health-Promoting Probiotics The genomic era has revolutionized our understanding of probiotics, the way these micro-organisms behave under different conditions and their tendency to respond to different stressors. Dr Harro Timmerman’s presentation will examine the way in which this knowledge has been harnessed and converted into genomic tools that aid industrial partners in increasing industrial performance and developing a better understanding of the health-promoting properties of these micro-organisms.

Immune Regulation and Host–Pathogen Interaction Dr Claudio Nicoletti, Research Leader at the Institute of Food Research (UK), focuses his research on immune regulation in the gut and host– pathogen interaction. To maintain a correct intestinal homeostasis, it is necessary for the gut epithelium and gut immune system to monitor the luminal contents. Together they must also co-ordinate and implement swift and effective responses. The structure and function of the intestinal immune system and host–bacteria interaction will be addressed in his presentation in addition to antigen sampling in the gut, recent findings in the area of lympho-epithelial interaction and host–bacteria interactions.

For more information View the full Vitafoods Europe Conference programme at www.vitafoods.eu.com/conference.

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May/June 2011 www.nutraceuticalmag.com

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COSUCRA Groupe Warcoing: The Belgian company (Stand 880) develops and produces natural ingredients made from chicory and yellow pea for health foods in more than 40 countries worldwide. Products are adapted according to the nutritional needs and concerns of every age group and those on show will include the company’s Pisane range (pea protein isolate), its Nastar range (pea native starch) and its Fibrulose range (chicory oligofructose). Visitors to Neptune Technologies & Bioressources Inc.’s stand (875) will be able to discover its recently launched krill product: Eco Krill Oil (EKO), which is a real competitor to others on the market. The company’s Neptune Krill Oil (NKO) is the only product to have been granted six specific health claims by a globally recognised health directorate.

Exciting Soy Solutions Solbar will present a wide range of products for the dietary supplement, health and wellness markets. The company will highlight its state-of-the-art soy isoflavone extracts, which offer the women’s health therapeutics market a safer active pharmaceutical ingredient (API). Solbar integrates its isoflavones, produced in standardized processes and confirmed in their concentration by validated analytical methods, into the development of alternative relief solutions for the menopause and osteoporosis. Solbar is the only soy isoflavones supplier that provides unique powder grades that are compatible with a variety of applications, and are ideal for the dietary supplement and pharmaceutical markets. Solbar will also present its wide range of soy which the low viscosity isolated soy protein, Solbar Q 842, will be of interest to the producers of protein bars and extruded snacks, whereas beverage producers will be introduced to Solbar Q 735, a calcium-fortified isolated soy protein designed for ready-to-drink beverages and other beverage applications. As a global leader in the soy ingredients market, Solbar is dedicated to developing healthy, costeffective soy ingredients. For more than 60 years, the Solbar team has been committed to bringing innovative and custom-made solutions to their clients (www.solbar.com).

Pont Europe (Stand 541) will be launching new additions to its contemporary collection of polypropylene packaging, Polypacker. Customers will be able to benefit from the same range but in smaller sizes: 100, 150, 225 and 300 mL, all of which are ideal for food supplement tablets. The new items in the Polypacker collection also offer added flexibility, shorter delivery times, improved strength, durability and barrier capacities (compared with HDPE). The Korea Biotechnology Industry Organization, in collaboration with KOTRA (Korea Trade-Investment Promotion Agency), is organizing the Korean Pavilion (K1–15) at this year’s Vitafoods Europe. In addition to last year’s nine participants (Neo Cremar, AK Biotech, Suheung Capsule, Hwail Pharmaceutical, Amicogen, Chemport, Wellbeing LS, Bifido and Glucan), four new exhibitors (Damian, Tobico, Brain Tropia and Neuropid) will exhibit for the first time. At Vitafoods Europe, Korean companies will be showcasing products for glycemic control and joint treatment as well as functional food products that are made water-soluble using nano-emulsion technology. The Korea Biotechnology Industry Organization, in collaboration with KOTRA, is promoting the joint booth to support export opportunities and to explore ways to further promote Korea’s bioindustry through interaction and co-operation with foreign buyers and partners. Vitamins For Life (Stand AP29) will be showcasing its revolutionary new weight loss supplement, Solani, launched at the end of March. Made from an all-natural proprietary blend of plant and potato fibre, the supplement is taken with water and forms a natural gel that expands in the stomach. This provides a full feeling at mealtimes, but also helps to reduce the rate at which food leaves the stomach, to encourage the consumption of smaller portions.

Two Antiageing Challenges, One Nutricosmetic Solution The mechanisms of skin ageing are multifactorial and include genetics, sun exposure, environmental stressors and more. Comprising a natural combination of chondroitin sulphate, hydrolysed collagen and glucosamine, PROTEIN M+ contains multiple active compounds to target numerous pathways. PROTEIN M+ synergistically combines the same proteins and polysaccharides that are found in skin: collagen fibres give the dermis tensile strength and polysaccharides prevent moisture loss. Several clinical studies have shown that PROTEIN M+ polysaccharides and hydrolysed collagen are active in the dermis where they improve basic skin structure and texture, as well as the skin’s natural ability to retain moisture (+25% skin hydration). With time, PROTEIN M+ can also help to visibly reduce the appearance of fine lines and wrinkles, dilated capillaries and age spots, whilst improving the skin’s moisture balance. Results also show that PROTEIN M+ helps to repair sun-damaged skin. It has been proven that hair loss, suffered at some stage but nearly all men and a proportion of pregnant women, can lead to low self esteem. PROTEIN M+ is also able to address this sector of the beauty industry. Several placebo-controlled clinical studies showed that, with minerals and vitamins, the marine polysaccharide complex is effective in the treatment of hair loss. Results show an average hair growth increase of more than 30%. Although the mechanism of action has yet to be proven, it is suggested that the active marine complex is related to the production of dihydrotestosterone in the hair follicle, which is known to cause hair loss. PROTEIN M+’s unique extraction process makes it water-soluble and fully digestible. Its high bioavailability makes it ideal for oral cosmetics. For more information, visit Copalis (www.copalis.fr) at Stand 846.

Collagen Peptides for Skin Health As a major international player in the collagen peptide industry, Rousselot (Stand 849) produces and markets effective solutions for the health and beauty markets. At Vitafoods, Rousselot will highlight the benefits of its Peptan collagen peptides for skin beauty, bone and joint health, and as part of nutritional and weight management programmes. In nutricosmetic applications, Peptan Beauty products have proven their moisturizing and antiageing properties in recent clinical studies. For skin care and personal care applications, the new Peptan Cosmetic range has confirmed its ability to stimulate the synthesis of endogenous collagen in a number of in vitro studies. At the show, the company will unveil complementary studies on Peptan collagen peptides. In vitro and in vivo studies have recently testified to the advantages of collagen peptides to promote bone health. Their positive effects on joints have also been reported in numerous studies that have illustrated their efficiency in reducing joint pain in people suffering from arthritis and keen sportsmen and women. A pure protein, Peptan Collagen has also demonstrated its nutritional and functional relevance when used in foods and drinks promoting weight stability or even weight loss, or for optimizing the protein consumption of sportsmen and women and the elderly. The organoleptic properties of Peptan and its easy integration into new functional and dietary foods and drinks will also be showcased (www.rousselot.com).

www.nutraceuticalmag.com May/June 2011

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May/June 2011 www.nutraceuticalmag.com

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New Science for Cacti-Nea

Bariatrix Europe: a protein specialist for more than 30 years, Bariatrix Europe will be showcasing its new global solutions at Finished Products Expo (Stand 2430). After the success of its strawberry flavoured smoothie, the company will be exhibiting its new banana flavoured high quality protein supplements. Also on show will be two new low-calorie and proteinrich snacks, plus its range of low sugar cakes, sweetened with polyols.

At Vitafoods, Bio Serae Laboratories (Stand 940) will present the latest scientific developments regarding its full range of innovative nutraceutical ingredients. A second clinical study has confirmed Cacti-Nea’s diuretic effect. The open intra-individual trial was done at the end of 2010 and involved 15 women with water retention troubles. The aim of this study was to evaluate Cacti-Nea’s diuretic effect at a dose of 2 g/day for one week. Very positive results were highlighted, confirming the benefits of this innovative ingredient: it helps to significantly increase diuresis (27% in women with a BMI <25) and helps to significantly decrease swelling (feet, ankles, calves) and the feeling of heavy legs. Cacti-Nea is a natural prickly pear fruit extract that can easily be incorporated into dietary supplements or functional foods and beverages for diuretic and weight management applications. Serenzo, also from Bio Serae Laboratories, naturally helps to reduce the symptoms of stress, improve your mood and decrease stress-induced inflammation. Thanks to its well-documented properties, Serenzo offers a healthy alternative for use in dietary supplements for stress management. For more than 25 years, Bio Serae Laboratories has been developing innovative active ingredients for the nutraceutical and food industries and markets a comprehensive range of botanical extracts. Bio Serae’s ingredients are scientifically validated and offer natural alternatives for health applications, including weight management, cardiovascular health, sports nutrition and joint health.

General Care Products Co., Ltd (Stand 2034), manufacturer of confectionery goods, will have an assortment of candies, liquorice and fruit bars on display at Finished Products Expo. All made with the company’s innovative extruder machine, the products are both energy enhancing and nutritionally beneficial. US-based Nordic Naturals (Stand 2310) will be bringing an innovative delivery system for fish oil to Finished Products Expo. Visitors should visit the stand to see the latest product offerings and sample Nordic Naturals’ delicious omega-3 line. In particular, the company will be highlighting Omega-3 Effervescent, an innovative way to enjoy fish oil supplementation via a water-soluble drink mix containing EPA and DHA. It offers all the health benefits of omega-3s and vitamin D3, such as heart, brain, joint and bone support, without any hint of fish. Medex (Stand 2017) will be showcasing its range of natural food supplements that protect the body against harmful influences from the environment. Products include royal jelly, a mixture of proteins, fats and carbohydrates that helps to enforce the body’s immune system and give it strength and energy on a daily basis, plus Gelee Royale Junior, packed with vitamin C from azarole, vitamin E from soya and beta carotene. Probiotics manufacturer, Probiotics International Limited (Stand 2210), will be unveiling a new look for its award winning multistrain probiotic brand, Bio-Kult. It will also be talking to customers about the company’s new state-of-the-art manufacturing facilities in Somerset, UK, as well as its plans to gain EFSA probiotic health claims.

Top of the Agenda: Health for All Danisco (Stand 934) will demonstrate that a healthy, balanced diet is within everyone’s reach at Vitafoods and that when it comes to lifestyle choices and matters of health and nutrition, there’s no need to compromise. Living up to the promise to “bring health to everyday life,” the company will present scientifically proven ingredients and up-to-theminute sample concepts that offer something to all consumer age groups, from children to seniors. The focus will be on solutions that both meet the needs of today’s on-the-go lifestyle and pave the way to health and nutrition claims on end products. A world leader in probiotic development, Danisco will showcase HOWARU Balance, a family of probiotic supplements that bring digestive and immune health benefits to the whole family. Each of the three HOWARU Balance formulations contains a combination of the two most highly documented probiotic strains available — Bifidobacterium lactis HN019 and Lactobacillus acidophilus NCFM. Everyone will love waking up to a luscious orange juice, fortified to enhance their digestive system. Danisco has developed this refreshing concept with the whole family in mind. Containing the documented probiotic HOWARU Bifido and the dietary fibre Litesse, the feel-good sensation will last the whole day through. XIVIA, Danisco’s sustainable xylitol, makes peppermint chewing gum satisfyingly sweet and is 100% sugar free. XIVIA is recognized by the European Food Safety Authority (EFSA) to play an active role in reducing dental plaque — contributing to caries reduction (www.danisco.com/health).

Branded Health Ingredients Lonza is one of the world’s leading suppliers to the pharmaceutical, healthcare and life science industries. At this year’s Vitafoods, Lonza will be presenting its portfolio of branded health ingredients. Carnipure is high quality L-carnitine, a nutrient that’s essential for energy metabolism. Extensive research shows that Carnipure can play a beneficial role in many areas of health, such as weight management, sports nutrition, infant nutrition, male fertility and pregnancy. Made from naturally occurring microalgae, DHAid is a purely vegetarian source of omega-3 DHA. Health benefits of DHAid include the support of brain development and function as well as heart and eye health. ResistAid is an immune support ingredient made from North American larch trees, consisting of arabinogalactan and bioactive flavonoids, which have antioxidant capacity. Recently published research shows that ResistAid selectively enhances the immune systems of healthy adults. Lonza (Stand 743), will be showcasing products that contain its ingredients, such as Vitalia’s Slimline Museli Mix, containing Carnipure and sharing the newest research results on Carnipure and exercise recovery. (www.lonzanutrition.com/nutrition@lonza.com).

www.nutraceuticalmag.com May/June 2011

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High Content Natural Astaxanthin

Health Benefit Solutions

Algatechnologies (Stand 630), a leading manufacturer of natural astaxanthin, will launch 20% astaxanthin in oleoresin form. This astaxanthin content is significantly higher than in other forms of astaxanthin oleoresin currently available on the market (5–10%). The company recently announced that its AstaPure brand has obtained GRAS status from the US FDA for use in food and beverage applications. AstaPure can be applied to baked goods, beverages, cereals, coffee, tea, dairy products, hard candy, processed fruits and more. The AstaPure line also includes 10% astaxanthin oleoresin, 2.5% astaxanthin beadlets, 2% astaxanthin vegetarian beadlets as well as cold water-dispersible beadlets, 3% astaxanthin powder and 4 mg astaxanthin capsules supplied in bulk. All these products can be used in multiple forms of dietary supplements, cosmeceuticals, foods and beverages. Algatechnologies is a leading manufacturer of natural astaxanthin and the only supplier to use an entirely closed and transparent cultivation system that’s totally exposed to natural sunlight. Moreover, 100% of Algatechnologies’ products are manufactured using super-critical CO2 technology. Algatechnologies holds ISO 9001/2000, HACCP and GMP international accreditations (www.algatech.com).

DSM Nutritional Products (Stand 400) will showcase a number of innovative health and nutrition ingredients and solutions at this year’s Vitafoods, including two new Health Benefit Solutions: essentials for kids and teens and essentials for men. DSM’s new Health Benefit Solutions comprise a range of vitamins, minerals and functional ingredients that are formulated to meet the specific nutritional requirements of children and men. These new platforms complement DSM’s existing portfolio of 12 Health Benefit Solutions, which include Guard Your Heart, Upgrade Your Vision and Empower Your Mind, to name a few. Ingredients are available on their own or as a customized, preprepared Quali-Blends premix. Visitors will be able to sample the new and existing Health Benefit Solutions through a range of healthy ‘shot’ drinks. Also on stand will be DSM’s breakthrough heart health ingredient, Fruitflow, the first natural, scientifically substantiated solution for the promotion of healthy blood flow. With heart health high on the list of consumer health concerns, Fruitflow opens up the route to market for manufacturers of food, beverage and dietary supplement products. In addition to its broad ingredient portfolio, DSM also has the market knowledge and applications expertise to help manufacturers throughout the new product development process. On 12 May (11:00–15:00), DSM will host a presentation by Peter Wennström at their booth with a focus on developing consumer relevant functional foods using his renowned FourFactors Brand Analysis System. These presentations will be complemented by individual workshops in which customers will be given the chance to discuss their specific needs and questions. On 13 May, DSM is collaborating with Peter Wennström again to offer a VIP FourFactors master class to selected customers to demonstrate how you can use the FourFactors to communicate health benefits effectively with or without using a health claim (www.dsm.com).

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Men’s Health Focus

Ocean Spray Talks Whole Body Health Ocean Spray’s Ingredient Technology Group (Stand AP26) will be highlighting the whole body benefits of cranberry at this year’s Vitafoods. Although the cranberry is known for its role in maintaining urinary tract health, ongoing research details cranberry’s potential to support many different areas of the body, including cardiovascular health, gastrointestinal health and general health and well-being. Christina Khoo, Research Sciences Senior Manager at Ocean Spray, commented: “Since the first scientific study on cranberry in 1984, we’ve learnt a great deal about what the berry can do for us and how it works, particularly with regards to the anti-adhesion mechanism on bacteria in the urinary tract. Cranberry’s anti-adhesion mechanism is linked with inhibiting organisms such as E. coli and H. pylori from sticking to healthy cells. Now, studies are telling us that the potential health benefits are much wider.” She added: “The rich polyphenol content of cranberry helps to combat oxidative stress, helping to promote cellular and heart health and displaying anti-inflammatory properties. A 2010 study, for example, points to cranberry’s potential role in supporting cardiovascular health, finding that cranberry polyphenols may help to regulate vascular endothelial function.” Cranberry’s nutrient profile also includes vitamin C, quercetin and fibre, adding further weight to this berry’s holistic health proposition. Ocean Spray has been a leader in cranberry research for 65 years and is committed to supporting independent research into the whole body benefits of cranberry (www.oceansprayitg.com/www.oceanspray.com).

Naturally Healthy: All Around the World At this year’s Vitafoods, Frutarom (Stand 508) will showcase a selection of botanical extracts targeting jet lag symptoms. This “Jet Lag Campaign” has been created for people battling circadian dysrhythmia and offers a range of ingredients that help to balance the body’s inner clock. Frutarom will also present natural concepts for indications such as women’s health, bone health, slimming and beauty from within. An out-of-sync circadian rhythm causes stress, including daytime fatigue, exhaustion, disturbed sleep, digestive disorders and decreased mental and physical performance. This is particularly obstructive because people — such as business travellers — often have to be at their peak after a long flight. But it’s not just travellers who suffer from jet lag; doctors, chefs, shift workers and others live with “confused” inner clocks every day. The company’s “Jet Lag Campaign” is aimed at manufacturers of nutraceuticals and functional foods who want to create products for these target groups. The campaign includes extracts of blackcurrant, schisandra, fenugreek, wild green oat, lemon balm and red vine leaf. Each of these targets specific “jet lag” indications, such as concentration difficulties, stress management, sleep disorders, digestion problems, tired eyes and heavy legs. Depending on the individual product concept, the extracts can be used alone or in combination. Additionally, Frutarom will present its range of science-backed extracts using an indication-based approach: from digestive health and urinary conditions to mental health, cardiovascular and immune health, beauty from within, slimming, women’s health and bone/joint health, the company will showcase comprehensive concepts for the most diverse demands (www.frutarom.com).

www.nutraceuticalmag.com May/June 2011

There are almost 3.5 billion males in the world and 57% of those are between the ages of 20 and 65 years old. This group is becoming more and more concerned with maintaining good health to help sustain their productivity and to ward off the development of chronic diseases and their associated morbidity and mortality. As more men look to fortified functional foods and beverages to maintain their overall health and wellness, prevent the occurrence of specific health conditions or manage an existing health condition, growth within this category will continue at an unprecedented rate. Fortitech (Stand 639) is uniquely positioned as the only global company solely dedicated to the development and creation of custom nutrient premixes — more than 30,000 to date — for the food, beverage and pharmaceutical industries. During Vitafoods 2011, Johnny Thylin, PhD, Technical Director for Fortitech Europe ApS, will be presenting a technical seminar on the formulation and fortification challenges of food and beverages aimed at men’s health concerns. Dr Thylin’s presentation will address these issues and other challenges associated with developing a dynamic premix blend. Fortitech is also committed to helping to decrease the amount of people suffering from vitamin and mineral deficiencies in low income regions of the world. The company’s World Initiative for Nutrition (WIN) works with manufacturers to develop high quality fortified foods that are available and affordable. This often includes working with non-governmental organizations, governmental and international agencies aiming to improve nutrition to meet their specific needs. With on-demand support from Fortitech’s six facilities worldwide, WIN delivers nutritional solutions that are practical, effective and quality assured (www.fortitech.com/win).

When the heat is

This Cool It gets a lot of

Attention

Hot red pepper ingredient receives SupplySide Scientific Excellence Award Ideal for use in: ■

Weight management

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Diet control

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Sports nutrition

In animal and human studies, capsicum and capsaicinoids have been shown to: ■

Help manage appetite*

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Support healthy metabolism to burn calories*

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Help induce thermogenesis* (increase in energy expenditure in the body)*

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Help reduce body mass and body fat*

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Promote lypolysis (a breakdown of fat cells)*

The thermogenic power of OmniActive Health Technologies’ red hot pepper extract Capsimax is capturing the attention of the nutrition industry. A bonafide category creator, OmniActive’s Capsimax won the SupplySide Scientific Excellence Award, alongside GNC’s WELLbeING® be-ENERGIZED™ Calorie Burning Formula, in which Capsimax is the primary ingredient. Capsimax utilizes a breakthrough beadlet technology that delivers the metabolic boost of capsicum—without the burn! A proprietary formulation, Capsimax encapsulates a highly-concentrated natural capsicum fruit extract, manufactured from the active principles of hot red peppers (a global diet staple for centuries). The encapsulation technology delivers highly-effective levels of active capsaicinoids without the oral or gastric irritation associated with unprotected hot red pepper.

1-866-588-3629

Watch an informative 3-minute video at www.capsimax.com *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Capsimax Capsicum Extract has been selected as a finalist in the “most innovative ingredient” category of the NBT Awards.

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The Best of Nature The needs of consumers and, thus, the challenges facing the nutraceutical sector are numerous, including naturalness, nutrition, sustainable development and innovation. This year at Vitafoods, Roquette (Stand 774) will present global solutions that not only transform these challenges into opportunities, but also give free rein to innovation. In addition to the nutritional and health benefits of its ingredients, and their technological functionalities, Roquette offers in-depth scientific, nutritional, technical, regulatory and marketing support. A key objective is helping nutraceutical players to maximize their investment in innovation. Roquette’s development teams will be revealing promising ideas for nutraceutical product concepts, aimed squarely at consumer needs, including: • Plant-based well-being: A sustainable, 100% natural protein tablet demonstrating all the development potential offered by the NUTRALYS range of proteins; a 100% NUTRIOSE soluble fibre tabletop product produced from wheat or maize; an essential nutrient concentrate in the form of chlorella tablets (microalgae). • Health benefits: Maintain a slim figure and indulge yourself: that’s the practical and original solution offered by the appetite-reducing Satiety Smart Stick, which exploits the nutritional properties of NUTRIOSE; LYCATAB mineral tablets, an essential ally to bone health produced with directly compressible calcium carbonate. Nutraceutical product innovators visiting the stand in search of formulation help will find solutions tailored to their needs. Thanks to its complete range of plant-origin excipients, Roquette can also offer solutions that meet the requirements of diverse manufacturing processes. Roquette’s outstanding experience in the nutrition-health field means it can work with and for its customers to develop innovative solutions that are both pragmatic and sustainable (www.roquette.com/www.roquettenutra.com).

High Quality Chitosan Production Primex ehf is an Icelandic marine biotech company and a global leader in the environmentally friendly production of certified natural, pure and high quality chitin and chitosan derivatives, active ingredients for the food supplement, nutritional, cosmetic, food and biomedical markets. The raw material — fresh shrimp shell — and production contributes to the complete utilization of natural resources. The use of marine stocks around Iceland is regulated by the government according to scientific criteria (Icelandic Marine Research Institute) to ensure the self-sustaining utilization of natural resources. Primex products include the following: • L ipoSan Ultra is a unique, patented product that is a safe and effective weight-loss supplement that also contains succinic acid, a GRAS food additive. It is backed by solid science and human double blind, placebo-controlled studies. In the digestive system, LipoSan Ultra complexes and traps fats and oils and reduces the digestion of dietary fat. •C hitoClear is a premium-standard chitosan that is used worldwide in food supplements, nutritional, biomedical and cosmetic products. It is odourless and tasteless and proven to be the purest and most effective chitosan available, with very low amounts of contaminants such as heavy metals. • Newly launched is a ChitoClear wound healing gel for large and small animals, and ChitoClear chitin, a premium-standard chitin with very low levels of heavy metal contaminants (www.primex.is).

Since the first scientific study on cranberry in 1984, we’ve learnt a great deal about what the berry can do for us and how it works, particularly with regards to the anti-adhesion mechanism on bacteria in the urinary tract.

Emerging Science Supports Tocomin Products

New Science Park Opening

An increasing amount of positive research is pointing towards natural fullspectrum palm tocotrienol complex as having unique and far more significant health improvement potential than conventional vitamin E alpha-tocopherol. Recent clinical trials with Tocomin and Tocomin SupraBio have shown that these two branded ingredients support neuro-, cardiovascular and prostate health, as well as skin health. Patented and bioenhanced palm tocotrienol complex (Tocomin SupraBio) used in human studies was found to augment the post-vaccination challenge immune response, help to resolve non-alcoholic fatty liver condition (a major risk factor for metabolic syndrome) and promote hair growth. Tocomin SupraBio is currently being used in the largest ever clinical trial for its effects in neuro- and cardioprotection. At Vitafoods this year, Carotech (Stand 1047) will present a new ingredient — TocoBev 15% — a water dispersible powder form of natural full-spectrum tocotrienol/tocopherol complex for the production of functional drinks and powdered beverages. The Tocomin range of products is now GRAS-certified for both food and beverage applications. An independent panel of toxicologists reviewed extensive dossiers that included methods of preparation, compositional profile and safety/ toxicology studies. In addition, Carotech has also received an official “Letter of No Objection” from the US FDA regarding the self-affirmed GRAS status of its Tocomin products (www.carotech.net/www.tocotrienol.org).

DIANA NATURALS recently inaugurated its new research and development centre — DIANA NATURALS SCIENCE PARK — at its Rennes Atalante Champeaux site. This new location will allow DIANA NATURALS to reinforce its scientific and innovative partnership position with its clients in the food industry, both locally and on a worldwide scale. DIANA NATURALS invites its partners, customers, suppliers and institutional stakeholders to discover the new R&D centre. The inauguration included a visit to the analytical and development laboratories, as well as the new technology pilot plant where invitees were able to discover some examples of DIANA NATURALS’ products in application. This was followed by a presentation from Jean-Yves Parisot, President of DIANA NATURALS, and the opportunity to discuss the company’s new organoleptic solutions. DIANA NATURALS’ recent move to the Rennes Atalante Champeaux Science Park in September 2010 has enabled the company to drive performance. From innovation to product development and application, DIANA NATURALS develops more solid technical support with key stakeholders in the food industry. It has worked hard to achieve its position in what is a wide scientific and technical network, offering its customers the targeted functional solutions they need (www.diana-naturals.com).

www.nutraceuticalmag.com May/June 2011

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Fi Asia-China Returns to Shanghai China offers a rich tapestry of traditional and functional food ingredients. Fi Asia-China, Hi and Ni China, in conjunction with CPhI China and Nutraceuticals Products China (NPC), is the biggest exhibition in the country dedicated to the food, nutraceutical and pharmaceutical industries. The show will feature more than 2100 exhibitors and is expected to attract over 42,000 visitors from Asia and beyond. The show organizer has teamed up with IUFoST (the International Union of Food Science and Technology) to put together a highly innovative conference that will feature some of the best minds in academia and industry. Speakers will share their experiences and strategies for success, helping to create and develop a new market niche and safely and economically enhance existing products. Speakers include Professor Paul Singh, member of the US National Academy of Engineering, Dr Rickey Yada, Canada Research Chair of Food Protein Structure and an expert on nanotechnology, Dr Michael Knowles, Vice President of Global Scientific and Regulatory Affairs for Coca-Cola and Dr Bernhard Van Lengerich from General Mills. The event will also offer a variety of technical seminars, product showcases, a matchmaking programme and association conferences (www.ingredientsnetwork.com/china).

NATrueRAL Hydroxytyrosol Andalusia (South of Spain) is not only a wonderful place to spend a holiday, it is also the main area of olive oil production in the world. More than 35% of international oil production is derived from its 1.5 million hectares and 175 million trees. And, right in the centre of Andalusia is Genosa, a private company that was founded to develop a clean and sustainable internationally patented technology to extract the main orthodiphenol from olives — hydroxytyrosol. Hydroxytyrosol is a simple molecule with a low molecular weight; it is stable, has low toxicity and is highly bioavailable. Present in virgin olive oil and table olives, together with oleic acid and some other minor compounds, it forms part of the healthy Mediterranean Diet. After almost 10 years of hard work and determination, Genosa is the first company to launch a 100% natural olive fruit extract with the highest concentrations of natural hydroxytyrosol. The company is taking a fresh approach to “natural,” capitalizing on the marketing messages: “As natural as you” and “Natrueral.” Genosa’s technology uses only physical and mechanical procedures and is both solvent- and additive-free. According to taste and culture, olives and olive oil are not always to be found in the kitchen. But, as hydroxytyrosol’s only source is the olive, products such as Hytolive mean that every consumer will be able to benefit from hydroxytyrosol’s health benefits. Hytolive has no fat as it comes from the olive fruit’s water phase, so its caloric energy is low. Although free hydroxytyrosol is water soluble, Genosa has been working hard to ensure that Hytolive can be used in both water- and fat-soluble products. At present, Hytolive can be used in a variety of applications, such as beverages, dietary supplements, cosmetics, etc, resulting in a very wide portfolio of customers. Olive is a global concept with well-recognized health benefits, which makes Hytolive’s importance in the world of health ingredients easier to communicate. With a global presence and Hytolive being added to products in Japan, Taiwan, Pakistan, Spain and beyond, Genosa has only just started (www.genosa.com).

May/June 2011 www.nutraceuticalmag.com

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ADM Highlights Nutritional Expertise At Vitafoods, ADM (Stand 751) will demonstrate its wide-ranging capabilities and functional product portfolio in the health arena. The company will showcase its CardioAid range of phytosterols and phytosterol esters, which have approval as novel food ingredients and can be used in a variety of food and beverage applications targeted at reducing blood cholesterol levels. They help manufacturers of functional foods to capitalize on the approved EU health claim stating: plant sterols have been shown to lower/reduce blood cholesterol. Also for the promotion of good health, ADM will be offering Novasoy soya isoflavones that help with the tell-tale signs of the menopause, including hot flushes and are suitable for supplements, functional foods and beverages. Another highlight is Novatol, a natural source of vitamin E, which is needed by the body to protect cells and support natural defences. Also on show will be the Decanox range of natural antioxidants for food, feed and cosmetic use (www.adm.com).

To date, efforts have been made to reduce sugar and fat levels in ice creams, but no real diet options exist for consumers wishing to control their weight without depriving themselves.

SHAKE & FREEZE: The Ice Cream Event This year, Laboratoire PYC (Stand 2120) will present its SHAKE & FREEZE concept at Finished Products Expo. The innovation, unlike anything else on the market, consists in an ice cream adapted to a high protein, low calorie weight-loss diet. “The product is shelf-stable and has been designed for brands selling through drugstores and health shop channels,” says Aurélie De Schuyteneer, Marketing Manager. It is a powder mix that you rehydrate in a shaker and simply freeze. The finished product has a similar creamy sensation and taste as traditional ice cream. “To date, efforts have been made to reduce sugar and fat levels in ice creams, but no real diet options exist for consumers wishing to control their weight without depriving themselves of delicious ice cream. We had to create a new efficient offer.” For this concept, “Laboratoire PYC has made a point of using only natural flavours, no artificial colours, no preservatives and non-GMO ingredients,” adds Dominique Thiery, R&D Manager. Furthermore, product recipes are inspired from mainstream ice cream market trends incorporating real chocolate or fruit pieces. To develop a high protein product that’s also a low fat, low sugar ice cream, Laboratoire PYC relied on Ingredia Nutritional’s milk protein isolate and ice cream application expertise. The supplier’s protein, Prodiet 95 S, was chosen for its functional and nutritional properties. Its low content in fat and lactose, as well as its good amino acid profile, make it fully adapted to weight management applications. It also has a pleasant milky taste, a good solubility and interesting water-binding properties that help to keep the creamy texture, which is so important in an end-product such as ice cream (www.laboratoire-pyc.com).

Nutritional Lipids Polaris (Stand 609), an innovative nutritional lipid company, offers a wide range of health ingredients and a new high value “custom manufacturing” service. In cardiovascular health, Polaris will present its new “cardio concept” containing a 100% natural marine-derived active: “ASTA PRO 1000.” An enzymatic hydrolysate of wild Northern shrimp, combining amino acids (proteins), omega-3s (EPA/DHA), phospholipids and astaxanthin, this innovative concept focuses on the prevention of cardiovascular diseases. Polaris will also present its 40% GLA TG Borage oil, Qualitysilver. This highly stabilized oil is an incomparable source of omega-6 GLA that’s ideal for innovative nutraceutical formulations for specific health applications. In addition, the company will highlight its pumpkin seed oil, which is naturally rich in beta sitosterol, and demonstrate its latest innovation in food applications: a powder that’s rich in omega-3 DHA, has no taste, no odour and ideal for bakery products. For its entire range of nutritional lipids, Polaris ensures the high stability and purity of the marine and vegetable oils used thanks to its QUALITYSILVER patented process; this stabilizes oils that are rich in polyunsaturated fatty acids by delaying oxidation. The organoleptic and nutritional properties of the marine/vegetable oils used are thus protected (www.polaris.fr).

www.nutraceuticalmag.com May/June 2011

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arin e

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Sweet Results for Tate & Lyle and BENEO Several health claims have recently received positive feedback from ESFA, paving the way for further industry innovation. Welcome was the news that Tate & Lyle’s (www.tateandlyle.com) sugar replacement ingredients, polydextrose and sucralose, have garnered a positive opinion from the European Food Safety Authority (EFSA) in relation to their health claims regarding the “reduction of post-prandial blood glucose response” and the “maintenance of tooth mineralization.” These claims were approved by EFSA evaluation and will now proceed through the remainder of the European regulatory process for authorizing health claims. Significantly, this opinion will serve as a benchmark to inform future decisions of the European Commission and member states that are engaged in a process of authorizing European health claims. The company reaction was voiced by Caroline Sanders, Global Marketing & Communication Director, who remarked that their confirmation of “the science behind our ingredients is an important step to allowing Tate & Lyle’s food and drink manufacturer clients to communicate the health benefits, in turn allowing consumers to make more informed purchasing decisions.” The release of EFSA’s fourth batch of evaluations also held good news for Beneo, as its claims for Isomalt and Palatinose (isomaltulose) received positive feedback. The claims in question relate to two health areas affected by food choice: the maintenance of dental health and low glycaemic effect, which concerns the reduction of post-prandial glycaemic response. Despite this success, the Beneo Institute maintains its awareness of how much of the ‘claims journey’ is yet to be travelled. EFSA concluded that the consumption of food or beverages containing Isomalt or Palatinose, instead of easily fermentable carbohydrates such as traditional sugars, might help to maintain tooth mineralization by decreasing the rate of demineralization. EFSA also established a cause and effect relationship between the consumption of these ingredients as an alternative to traditional sugars and a reduction in post-prandial blood glucose responses. These results confirm the scientific substantiation for the use of both functional carbohydrates and indicate that EFSA acknowledges the specific physiological characteristics they offer to improve the health-related properties of final products in which they are included. Demonstrating that the “comparative or replacement claims discussion,” in which several macronutrients were held in 2009 has resulted in a solution, the outcome of the review encourages Beneo in its development of new dossiers to secure the health benefits of its ingredients and fuel future innovation in the food industry (www.beneo-institute.com).

Two Innovative Products from Indena Indena, the leading company dedicated to the identification, development and production of active principles derived from plants, will be exhibiting two new and innovative products at Vitafoods 2011 (Stand 620). The first of these, Meriva, has already been awarded “Best New Product” at the European Outsourcing Awards. It is a standardized curcumin mixture formulated with Indena’s Phytosome technology and has been proven to increase levels of curcumin absorption by 29-fold when compared with an unformulated product. To combine curcumin, Indena employs a phytosome matrix that functions by formulating the active ingredient with soy phospholipids. This results in the increased bioavailability that Meriva demonstrates. It does not stop there; studies have already confirmed the efficiency of Meriva as an anti-inflammatory agent in the treatment of diseases such as osteoarthritis and uveitis relapses and other eye diseases. The second product created by Indena has shown considerable potential in the supplementation treatment of weight issues. The novel combination of two highly standardized botanical extracts — Cynara scolimus (artichoke) and Phaseolus vulgaris (kidney bean) — was seen in a clinical trial to have positive effects in improving the satiation feeling of subjects and balancing glucose and lipid metabolism. In a separate trial Cynara scolimus also assisted on decreasing fasting blood glucose, insulin resistance and total, total/HDL and LDL cholesterol. Considering the positive correlations of being overweight to levels of cardiovascular disease, diabetes and cancer, innovation in this area of nutraceuticals is much needed (www.indena.com).

KonaRed Superfruit The fruit of the world-renowned coffee plant that surrounds, protects and nourishes the coffee bean, KonaRed is the new powerful superfruit product that hails from Hawaii. A product of Botanical Products International (Stand 2200), KonaRed is handpicked at the height of nutrient power when the fruit is ripe, red and at its peak of freshess. The product is both clinically tested and proven to have an extraordinarily high content of its nutrients and bioavailable antioxidants that are absorbed at the cellular level and known to help prevent disease, delay ageing and provide a longlasting mood boost. Of these antioxidants, those of most significance are quinic acid, known for its antiviral properties, chlorogenic acid, recognized for its properties as an appetite suppressant, and ferulic acid, a clinically proven anti-inflammatory. KonaRed is available in several forms. The powder form is suitable for powdered beverages, capsules, tablets, stick packs, softgels and foods, whereas liquid extracts may be used in RTD beverages, cosmetic applications and softgels. BPI will also be presenting other superfruits, such as goji, açai, noni, mangosteen, maqui and coconut water, and caricol, a unique digestive energizer from the papaya fruit (www.bpi-fmb.com).

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The Kids Are All Right Involved in the development, manufacturing and marketing of a broad range of childfriendly, innovative dietary supplements, Anlit Ltd (Stand 2027) will reveal a number of exciting, cutting edge products at Finished Products Expo 2011. Anlit’s products are natural, without artificial colours, preservatives and GMP, ISO9001:2000, HACCP compliant and Kosher certified and based on well-known carriers for conditionspecific solutions. Sweet Dreams: designed to help children sleep better during the night, this is a sugar-free milk-based formula with an excellent texture and tasty milky vanilla flavour that also contains Lactium. This product is the result of a collaborative effort with Ingredia (France) and targets children from 1–14 years of age. Oral-Health Probiotics: a powerful combination of BLIS K12 probiotics, naturally found in our oral flora, and xylitol for the prevention of tooth decay, that enhances the immune response and oral health. Research demonstrates that children taking oral BLIS K12 experience 50% less “Strep throat” episodes and less reoccurring otitis media. Immune System: new delicious gummy bears containing highly concentrated Sambucus nigra, as well as rose hip extracts, which help to boost overall immune system health (www.anlit4kids.com).

A Single Instrument with a Wide Application Bruker Optics, part of the Bruker Corporation, is the leading manufacturer and worldwide supplier of Fourier Transform Infrared, Near Infrared and Raman spectrometers for various industries and applications. It is a source of great excitement, therefore, that the company will be showcasing its FTNIR Multi Purpose Analyzer (MPA) at Vitafoods 2011 (Stand SP30). Involved in the field of FT-IR spectroscopy since 1974, the product line has been continuously expanding with instruments suitable for both quality control and research applications with exceptional performance characteristics. FT-NIR spectroscopy is already employed in all areas of the pharmaceutical and food industries for the identification and quantification of raw materials, in-process materials and finished products throughout the product chain, and promises to have a big impact on the nutraceutical market. With the FT-NIR MPA, Bruker is providing a single instrument that is able to address a wide range of applications in food analysis. Dedicated sampling accessories are available for any type of liquid, powdered, semi-solid or solid sample, meaning that any person either in production or the lab is able to perform an analysis as sample preparation is unnecessary. In addition, the fast measurement time allows for total control of all incoming raw material batches: a better quality product is thus available at a lower cost (www.brukeroptics.com).

“ We at DSM believe that adequate nutrition should be a human right for everybody, and not only for those who can afford it.” There is a way we can help to improve the lives of millions of people around the globe. We can take steps to eliminate micronutrient malnutrition or ‘hidden hunger’ by fortifying food with essential vitamins and minerals. Ensuring that people’s diets contain adequate amounts of all the micronutrients they need would not only improve their state of health, productivity and learning abilities, it would make it easier for them to throw off the bonds of poverty as well. DSM’s Nutrition Improvement Program has taken an active role in the elimination of hidden hunger. The global team provides technical and scientific support for supplementation and fortification programs and develops tailor-made products for specific needs of people in developing countries. To find out more, please visit www.nutritionimprovement.com

May/June 2011 www.nutraceuticalmag.com

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Bioactive Collagen Peptides Stimulate Body Functions VERISOL: Real Beauty Comes From Within In Asia, collagen-based beauty products are already well established and collagen has been particularly successful in a variety of functional foods and nutraceuticals. Asian consumers, especially women, have long since recognized the value of collagen to promote beauty. In Europe and the USA, consumers are aware of collagen’s benefits — mainly because of the claims made for topical applications — but collagen is still a rare ingredient in dietary supplements, health and nutrition products and in nutricosmetics. The established Asian trend is clearly moving west, however, under the banner of “Beauty from Within.” Orally administered VERISOL® influences skin metabolism from the inside, increasing skin moisture levels and preventing the formation of wrinkles. It is produced from native collagen and has excellent bioavailability. It can easily be incorporated into a wide variety of products — from pharmaceutical-like applications such as capsules, film-coated tablets, standard tablets and capsettes to indulgence products such as chocolate or instant coffee. Qualitative market research done by the Institute für Zielgruppenkommunikation (IfZ, Germany) shows the great potential for the “Beauty from Within” concept in Europe and the USA.

FORTIGEL: Regenerating Joint Cartilage Around the world, more than 25% of the population suffers from joint problems; this represents a considerable loss of quality of life. The principal reason for these problems is wear and tear of the joint cartilage — brought about by increasing longevity, being overweight through lack of activity or the mechanical stress of intensive sport. Despite considerable medical progress, there is still no cure for osteoarthritis and only a few therapeutic remedies to treat the disease. In most cases, the symptoms are treated … and not the cause. However, FORTIGEL® tackles this problem in a completely different way. After oral administration, FORTIGEL stimulates the cartilage cells to increase the production of both collagen and proteoglycans — the two major components that make up almost 90% of cartilage dry mass. By treating the causes and not just the symptoms, FORTIGEL considerably improves joint mobility, reduces pain and hence produces a higher quality of life. FORTIGEL Plus, a recent line extension with added cynosbati (rose hip extract) provides an additional anti-inflammatory effect. Thus, FORTIGEL Plus perfectly completes the FORTIGEL family as it serves another important target group, opening up the market to further opportunities.

Gelita Group GELITA is a leading manufacturer and marketer of collagen proteins. With headquarters in Eberbach, Germany, GELITA provides customers around the world with products of the highest standard, comprehensive technical expertise and sophisticated solutions. More than 20 sites, 135 years of experience and a global network of experts ensure that state-of-the-art know-how is always available for customers. A strong requirement for innovation is the driving force of the family owned company that is continually looking for new solutions. Visit GELITA (Stand 968) at Vitafoods and convince yourself how VERISOL and FORTIGEL can contribute to the success of your product ranges (www.GELITA.com).

www.nutraceuticalmag.com May/June 2011

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21 ®

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The 4 generation folate th

• Long lasting stability • High water solubility • Improved bioavailability • Established safety

Quatrefolic® is FINALIST for the NBT Awards in the “Most Effective Strategic Product Development” category.

May 10-12, 2011 Visit us at Booth #842 Geneva Palaexpo, Switzerland

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May/June 2011 www.nutraceuticalmag.com advanced biotech

NBT awards

in association with

A Celebration of Food Innovation

The Nutraceutical Business & Technology Awards and Roundtable: two new launch events for the nutraceutical manufacturing industry.

n partnership with Vitafoods Europe and the Finished Products Expo 2011, the Nutraceutical Business & Technology Awards (NBTA) is a launch event to recognize excellence in research and development, marketing, business and technology within the nutraceutical industry and across the entire sector, looking at ingredients, production, finished products, applications and business practices. The mission of this new gala dinner ceremony is to deliver a set of benchmarks that will provide a pan-European/global audience of nutraceutical professionals with the opportunity to recognize significant developments in quality of service, health management, R&D and relationship management, and will also provide a recognized and tangible reward for the successful companies. Offering both a professional and social platform on the second evening of the flagship Vitafoods Europe event (10–12 May 2011, Geneva Palexpo), the NBTA will bridge an existing gap at one of Europe’s largest meeting places for the nutraceutical industry and gain maximum exposure from the existing professionals in the fields of functional foods, cosmeceuticals and nutraceutical ingredients who will be exhibiting and attending. The awards evening will comprise a cocktail networking reception, gala dinner, awards presentation with after-dinner speakers and entertainment. Award winners will be presented with trophies that set a benchmark for recognizing success within the nutraceutical industry. Vitafoods Europe Event Director, Chris Lee, commented: “We’re delighted to be launching the NBTA at Vitafoods Europe. There is a huge gap in the market for awards such as these and we’re really looking forward to honouring the best in the industry. A huge amount of innovation goes on in this industry that simply doesn’t get the

www.nutraceuticalmag.com May/June 2011

credit or recognition it deserves.” There will be eight categories in total, comprising Most Innovative Ingredient, Most Effective Strategic Product Development, Outstanding Application in Health Management, Most Effective Marketing Campaign, Environmental Excellence, Most Improved Product Safety and Quality, Best New Plant/Process/ Technology and Best New Finished Product. Now in the throes of judging and assessing the nominations, head judge Dr Kevin Robinson, commented: “The response to NBTA has been almost overwhelming. We’ve been deluged with an unprecedented number of high quality submissions from all over the world. I am extremely grateful to the esteemed judging panel for generously donating so much of their time and expertise; it has been a challenging and fascinating task to sort through the entries and score them all. The functional food and drink industry has evidently been looking for an event such as this for some time.” Much like Via Media’s sister event, the European Outsourcing Awards, a numerical scoring system is used to ensure that the judging is objective. Three members of the judging panel independently assess each shortlisted nomination; their scores, and any comments or critique, is then sent back to the head of the judging panel. The three scores are averaged and the result is stored away ... until it is announced at the NBTA gala dinner. Not long to wait now! Also new to the show and taking place alongside the NBTA will be a business roundtable, organized by Via Connect, which will feature some of the world’s major health, nutrition and wellness companies taking part in a lively debate about overcoming the barriers to

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commercial success. Panellists will discuss the trials and tribulations of getting consumers to adopt and accept functional food and drink products (see sidebar). Reviewing the roundtable programme, Ewa Hudson, Head of Health and Wellness Research at Euromonitor International Ltd, said: “Weight management is arguably the most important preventive step that consumers can take when looking after their health, and many different approaches have been adopted in recent years. In the 1950s, we were told to “feed your children with fat,” aspartame arrived in the 1980s and there was shift towards zero calorie diets. After that, the “yo-yo effect” became an issue and weight management programmes such as Slim•Fast and Weight Watchers came into fashion, followed by the development of fat burning food and drinks, satiety products such as Optimel Control and a new range of sweeteners, including the naturally derived stevia. Yet, despite all this, obesity rates continue to rise across every one of the 80 countries that we research. Is there a solution that will finally work on a global level? I am very much looking forward to hearing the experts’ opinions regarding the future of weight management products that can help to stop escalating obesity rates and control consumer weight increases on a global level.”

EXCLUSIVE ROUNDTABLES

Roundtable Topics • What is the future for weight management products? Will new ingredients — marketed to consumers — be the answer or is it “behind the scenes” product reformulation? • How to make healthy food taste great? Low sugar, low fat, low salt products are often perceived as under-delivering on taste; yet, they are healthier. What can manufacturers do to overcome this perception? • Is segmented nutrition the future of nutraceuticals? How do we reach consumers with lower income and education levels? • How do we make commercial sense out of new product launches and achieve commercial sustainability? • How do we support the movement from treatment to prevention? Should more be expected from government bodies to promote healthy nutrition? • How do we demonstrate the efficacy of new products/ingredients without health claims?

For more information Miranda Docherty Awards Director Tel. +44 1372 364 122 miranda.docherty@via-medialtd.com www.nbtawards.com

When and Where? Wednesday 11 May The Starling Geneva Hotel and Conference Centre Geneva, Switzerland Champagne Reception: 7:00 pm Gala Dinner: 8:15 pm Awards Presentation: 9:30 pm Carriages: 11:30 pm

EXCLUSIVE ROUNDTABLE "The response to NBTA has been almost overwhelming. We've been deluged with an unprecedented number of high quality submissions from all over the world. I am extremely grateful to the esteemed judging panel for generously donating so much of its time and expertise; it has been a challenging and fascinating task to sort through the entries and score them all. The functional food and drink industry has evidently been looking for an event such as this for some time. Dr Kevin Robinson, Head Judge

May/June 2011 www.nutraceuticalmag.com

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Headline Sponsor Naturex (www.naturex.com) Naturex manufactures natural, specialized ingredients for the nutrition and health, food and beverage, and personal care industries. Headquartered in Avignon, Naturex employs 950 staff and has 11 production units located in Europe (France, Italy, Spain, Switzerland and the UK), the United States (New Jersey and California), Brazil, Australia and Morocco. In addition, the group has several sales offices worldwide.

primary Sponsors Ingredia Nutritional (www.ingredia-nutritional.com)

Biotivia (www.biotivia.co.uk)

Ingredia Nutritional specializes in the development, manufacturing and marketing of nutritional ingredients and solutions that are natural, premium and innovative. The Ingredia Nutritional ingredients, scientifically proven in their effectiveness, are designed for inclusion in the composition of health maintenance products in the nutrition and health industries. Our goal: to provide our customers with ingredients that ensure the success of their future products.

Biotivia’s products are unique in their use of synergistic ingredient formulations that deliver outstanding potency (and therefore greater efficacy) and increased value to our customers. Bio Quench is an example of how evidence-based design works to increase product strength: the combination of trans-resveratrol and superfruit extracts in Bio Quench has resulted in achieving an ORAC value of more than 13,500 units per gram, a new benchmark for super antioxidants.

Gala Dinner Sponsor

Champagne Reception Sponsor

Ocean Nutrition Canada Limited (ONC) (www.ocean-nutrition.com/www.meg-3.com)

Cognis (www.cognis.com)

ONC is the leading global supplier of omega-3 EPA and DHA ingredients derived from fish oil to the dietary supplement and food manufacturing markets. Our innovative and patented Powder-loc microencapsulation technology enables the food industry to include fish oil-based omega-3 in a wide variety of foods such as baked goods, dairy, juice and confectionary products. Our technology uses double shell protection, keeping the EPA and DHA locked into the microcap while ensuring that the smell and taste of the fish does not enter the food.

www.nutraceuticalmag.com May/June 2011

Cognis’ Nutrition & Health strategic business unit supplies product concepts for high-performance and natural-based modern nutrition to assist food, beverage and supplement manufacturers to achieve success by meeting consumer demands. Cognis is a worldwide supplier of innovative specialty chemicals and nutritional ingredients, with a particular focus on wellness and sustainability. It is part of the BASF Group, the world’s leading chemical company.

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additional Sponsors CreAgri (www.creagri.com) CreAgri is the world leader in the discovery and development of olive polypenols and hydroxytyrosol-based applications for dietary supplements, functional foods, beverages, cosmeceuticals and other industrial formulations. CreAgri’s principal product, Hidrox, is the result of more than ten years of innovative scientific research and creative technological solutions. Hidrox is an internationally renowned formulation and clinically proven to be effective in the management of many age- and stress-related conditions. It is the only organic, GRAS-certified, solvent-free, Halal and Kosher hydroxytyrosol-rich composition able to bring the healthy benefits of the Mediterranean diet, to both industry and consumer, in a highly bioavailable form.

Aker BioMarine (www.superbakrill.com) Aker BioMarine is an integrated biotechnology company dedicated to the sustainable harvesting of krill and the development of krill-derived biotech products. The company supplies biomarine ingredients through an optimized value chain from raw materials to customers. Aker BioMarine’s Superba Krill products are provided with 100% traceability from the Antarctic Ocean to the end user. In addition, Aker BioMarine is the only krill harvester that has been awarded Marine Stewardship Council (MSC) Certification.

Horphag Research (www.pycnogenol) Horphag Research is the exclusive supplier of Pycnogenol, a natural extract of French maritime pine bark. Pycnogenol is a powerful antioxidant, selectively binds to collagen and elastin, is a natural antiinflammatory and aids in the production of endothelial nitric oxide, which helps to vasodilate blood vessels. Among others, applications are cardiovascular health, skincare, eye health and joint health. More

Stratum Nutrition (www.stratumnutrition.com) Stratum Nutrition is a Novus International Business that focuses on human nutrition through supplying specialty and functional ingredients for manufacturers and marketers of foods, beverages and dietary supplements. Our portfolio offers branded, value-added ingredients that are progressive, safe and reliable. These ingredients are created with consumer need in mind and are supported both by science and by the backing of a trusted multinational company.

Croda Health Care (www.croda.com) The superior quality and purity offered by Croda Health Care makes it a supplier of choice when sourcing omega-3 ingredients to add value to your nutritional or food offering. Croda’s Incromega lipids are a range of highly purified omega-3 concentrates that offer potent solutions with recognized heath benefits. Croda’s concentrates provide high levels of EPA and DHA, enabling their customers to target specific consumer needs. The marine Incromega range is produced using PureMax: an advanced purification and concentration technology. Supported by a consumer awareness campaign, the PureMax stamp of approval is a unique selling point that omega-3 supplement manufacturers must include on their packaging.

Azelis Food & Health (www.azelis.com) Azelis Food & Health offers high quality ingredients to help you create the taste, texture, performance and appearance you need for your food, health and nutritional products. We are proud to represent cutting edge manufacturers at the forefront of new developments. Our innovative range of nutraceuticals offer solutions for antiageing, cognitive function, women’s health, eye health, weight management and immune system protection as well as mineral

than 280 scientific publications and 90 clinical trials have confirmed

fortification and a whole host of botanical extracts.

Pycnogenol’s safety, quality and efficacy. It is ISO, GMP-certified and

GRAS-approved.

Indena (www.idena.com) Indena is the world’s leading

Gumlink A/S (www.gumlink.com)

company dedicated to the

Gumlink A/S is the world’s leading B2B

identification, development and

manufacturer of chewing gum, which it

production of active principles derived from plants, designed for

has been producing for more than 80

use in the pharmaceutical, health food and cosmetics industries.

years. Recently, Gumlink entered the

The company produces standardized extracts from edible plants

nutraceutical arena with its new type of

that are traditionally recognized as having therapeutic properties, as

chewing gum: dual-layered compressed gum. This new gum facilitates

well as from plants that have proven pharmacological value. These

the effective delivery of active ingredients while simultaneously providing

are important ingredients in health food and food products. Indena

a great taste. Gumlink is committed to ensuring the high quality

standardized extracts have full chemical characterization supported

standards of ‘Made in Denmark,’ the country in which it is located.

by safety and efficacy tests.

May/June 2011 www.nutraceuticalmag.com

NBT awards

Genosa ID (www.genosa.com)

Lonza (www.lonzanutrition.com)

Genosa ID is the global leading

Lonza is one of the world’s leading

producer of an olive fruit extract with

suppliers to the pharmaceutical,

a high concentration of 100% natural

healthcare and life science industries.

hydroxytyrosol (Hytolive). Hydroxytytrosol

Lonza offers a portfolio of branded

is the major and most active

health ingredients with clear benefits

orthodiphenol present in virgin olive oil and olive fruit. It is a very simple,

backed by scientific evidence to the nutrition sector. Our products

stable, active and bioavailable molecule. Hytolive is manufactured under

include Carnipure, DHAid and ResistAid, and have applications in

an internationally patented technology characterized by the sole use of

many areas of health and well-being, including sports nutrition, brain

physical and mechanical processes and without the use of solvents; thus,

function, weight management and immune health.

it is the only 100% natural product of its kind. This makes Hytolive unique.

Cargill (www.cargill.com)

Symrise (www.symrise.com) Symrise is a global supplier of

Cargill is an international producer and

flavourings and functional ingredients

marketer of food, agricultural, financial

as well as fragrances and cosmetic

and industrial products and services.

active ingredients. Symrise works with

Founded in 1865, this privately held

its clients to develop new ideas and

company employs 131,000 people in 66 countries. We help customers

concepts for products that form an indispensable part of everyday life.

to succeed through collaboration and innovation, and are committed to

Our product solutions reflect our unique approach by combining better

sharing our global knowledge and experience to help meet economic,

health with more taste. Symrise — always inspiring more.

environmental and social challenges.

Neptune (www.neptunebiotech.com)

LycoRed (www.lycored)

Neptune Technologies & Bioressources

LycoRed is a global leader in

Inc. researches, develops and

healthy and natural fortification and

commercializes proprietary bioactive

colourants, serving the food, beverage,

ingredients and products that boast

nutricosmetics and dietary supplement

superior added value and clinically

industries. LycoRed’s product portfolio includes unique formulations and

proven health benefits. The company extracts a range of bioactive

microencapsulations, natural carotenoids, such as lycopene, lutein and

ingredients, such as novel proprietary omega-3 phospholipids, from

beta-carotene, vitamins and minerals, amino acids, functional ingredients,

abundant yet underexploited marine biomass that includes krill, a cold

natural food colours and flavour enhancers. LycoRed provides healthy,

deepwater zooplankton.

safe, high quality and novel value-added ingredient solutions for the nutrition, food and beverage, and dietary supplement industries.

Ninapharm (www.ninapharm.com) Founded in Annecy (French Alps) in

OmniActive (www.omniactives.com)

1993, Ninapharm’s core business

OmniActive Health Technologies

focuses on the development of

(OmniActives) supplies nutritional

antioxidant actives for the cosmetics,

ingredients to healthcare, food and

nutraceutical and pharmaceutical

personal care industries. OmniActives

fields. The unique nature of the laboratory is in its combination

has made a commitment to service,

of controlling the production of its antioxidant raw materials and

quality and reliability, freeing our customers to focus on their core

advanced chemistry. This allows the company to offer solutions ranging

business. OmniActives’s expertise extends from sourcing, cleaning and

from bioactive solubility and in vivo absorption (using its in-house

grading agricultural materials to extraction, distillation, isolation and

nanotechnology platform) to its medicalized food concepts. With a

purification. It also encompasses the standardization of extracts and

blue ocean strategy, Ninapharm supported the development of several

the granulation and formulation of specialty blends and products.

world-class products, from a top slimming formula in Europe, to a

bestselling antiageing cosmetic in Japan, making Ninapharm famous

Solbar (www.solbar.com)

as an innovator’s supplier.

Solbar, dedicated to supplying natural soy solutions to the food and nutritional

Gnosis (www.gnosis-bio.com)

markets, is a global leader in specialty

Harnessing 20 years of experience

soy proteins and soy isoflavones. Solbar manufacturers a wide range

in microbial fermentation and an

of soy protein concentrates and soy isolates for meat, vegetarian,

international manufacturing network

health food, nutritional bar, snack and beverage applications. Solbar

dedicated to high quality and proprietary

is a research-dedicated company focused on processing the soybean

products for pharmaceutical and

to create products with improved functional properties that emphasize

nutritional applications, Gnosis works to develop and introduce innovative

health benefits and ensure economic value. The company meets the

products to its customers. Services offered include product development,

highest standards of quality assurance for its customers.

formulation studies and tailor-made industrial production solutions.

www.nutraceuticalmag.com May/June 2011

Enhancing beauty from within with collagen peptides Rousselot (www.rousselot.com) As the world’s leading producer of gelatin and collagen peptides, Rousselot is committed to developing new, innovative products for changing markets. Providing solutions and support for companies in the food, nutrition, health and nutricosmetic industries, Rousselot is more than just a supplier. A staff count of 2400 allows the company to benefit from a global sales and production network of 12 plants and 10 sales offices located throughout Europe, North America, South America and Asia.

Lallemand (www.lallemand.com) Lallemand’s Human Health and Nutrition Division comprises two specialized business units: Institut Rosell-Lallemand is dedicated to the selection, development, production and marketing of documented probiotic formulations for the food and pharmaceutical industries; Lallemand Health Ingredients offers quality ingredients, sold under the brand name Lalmin, for food and supplement sectors such as premium cranberry powders and extracts for the herbals markets and enriched yeasts for the mineral and vitamins market.

Banner (www.banpharm.com) Banner is one of the world’s leading companies committed to the research, development and manufacture of softgel

Beauty

dosage forms for both the pharmaceutical and nutraceutical industries. Banner serves its European customers from its GMP-certified manufacturing site in the Netherlands, offering the

PeptanTM collagen peptides provide the amino-acids specific to skin health. It has clinically shown to help maintain youthful, vibrant skin and fight skin aging process.

best solutions to formulation challenges and marketing opportunities in prescription drugs, OTC products and food supplements.

EPAX (www.epax.com) Hailing from Norway, EPAX AS is

PeptanTM is flavorless, odorless, colorless and highly soluble, making it easy to use in your nutricosmetics.

a world-leading supplier of highly concentrated, marine-derived EPA/ DHA omega-3 oils to the global

Discover the benefits of PeptanTM collagen peptides from Rousselot, a world leader in manufacturing high quality ingredients for the pharmaceutical, nutraceutical, food and cosmetic industries.

dietary supplement industry. EPAX supplies top quality formulas with different EPA/DHA ratios and concentrations that target specific health conditions. Backed by clinical studies, EPAX products are available in TG and EE versions. The EPAX facility is certified for GMP and API production, is HACCP and ISO14001-approved, and the company boasts an integrated supply chain from sea to finished omega-3

Contact:

ingredient, which is also FOS (Friend of the Sea) certified.

peptan@rousselot.com www.peptan.com

LIVELIFE (www.livelife.com.my) markets innovative nutricosmetic and health products based on scientifically proven ingredients. R&D is handled by

Picture: istockphoto

LIVELIFE develops, distributes and

LIVELIFE BIOSCIENCES AG (Switzerland) and distribution and marketing is controlled by LIVELIFE INTERNATIONAL in China, Singapore, Malaysia and South Africa. LIVELIFE products include

Scan this QR Code with your smartphone to get more detailed information about PeptanTM.

Mireica, a nutricosmetic with stem cell rejuvenating properties (www.mireica. com), Rilax Zzz, a natural sleep supplement (www.rilaxzzz.com) and detox and weight management products, TruDtox (www.trudtox.com) and tripo-X. Product information may also be found on www.facebook.com.

May/June 2011 www.nutraceuticalmag.com

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Capsugel (www.capsugel.com) Boasting more than 2800 colleague and 10 facilities around the world, Capsugel is a global leader in innovative dosage forms and solutions for the healthcare industry. Capsugel offers a comprehensive array of products and services ranging from hard gelatin, softgel and HPMC vegetarian capsules to innovative R&D equipment and liquid formulations as part of its Licaps Drug Delivery System. It is at the forefront of drug delivery innovation, providing support to customers from formulation to final production.

Via Connect, an associate company of Via Media UK Ltd, the leading B2B publishing company, is a specialist provider of business roundtables and award ceremonies to the bio/ pharmaceutical, nutraceutical and personal care industries. In addition to the Nutraceutical Business & Technology Awards and Business Roundtable, Via Connect also organizes the European Outsourcing Awards, an annual gala dinner event designed to recognize excellence in R&D, marketing, business and technology across the bio/pharmaceutical and clinical trial industries. Via Connect is delighted to announce that two Pharma Roundtables will take place alongside this yearâ&#x20AC;&#x2122;s European Outsourcing Awards in Frankfurt on 26 October. For more information about Via Connect, including details of our forthcoming Nutra Business Roundtable at Vitafoods Europe (11 May), please contact Christopher Watt christopher.watt@viaconnect.co.uk Tel. +44 1372 364 132 Samuel Thangiah samuel.thangiah@viaconnect.co.uk Tel. +44 1372 364 133 www.nbtawards.com/nbta/roundtable.html

Can Consumer Product Companies Remain Neutral About Nutra Health? Panellists

Moderated by

www.nutraceuticalmag.com May/June 2011

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www.cereboost.com May/June 2011 www.nutraceuticalmag.com

GOED report

New Work on a Codex Standard for Marine Oils

he 22nd session of the Codex Committee on Fats and Oils (CCFO) of the Codex Alimentarius Commission (Codex), held in Penang, Malaysia (21–25 February 2011), saw the adoption of a slightly modified version of Switzerland’s proposal for new work on a Codex Standard for Marine Oils. The modification in question is: that the scope of any adopted standard will include only fish and shellfish oils, but not algal and mammal (such as seal and whale) oils. According to Codex classification, squid falls into the shellfish category, so the standard will also cover oils from cephalopods. In July, Codex will consider whether to endorse the CCFO recommendation to pursue the development of this standard. Those intimately involved with Codex are of the opinion that the endorsement of CCFO’s recommendation is a foregone conclusion. If true, the proposed new work on a Standard for Fish and Shellfish Oils will be developed according to the structures of the existing Codex Standards for fats and oils and will likely include the following sections: scope, description, essential composition and quality factors, food additives, contaminants, hygiene, labelling, methods of analysis and sampling, and tables with characteristic fatty acid compositions of the described oils. Although GOED has been part of an Informal Industry Work Group (IIWG) that was established, not to mention recognized by, the Swiss Delegation, to ensure that all issues were considered before Switzerland submitted its proposal for new work to the CCFO, it remains concerned that the adopted standard will not be flexible enough to allow for rapid innovation and natural variations in oil composition owing to environmental factors. If this occurs, the result would be the restriction, rather than promotion, of free trade. It would also limit consumers’ access to quality sources of EPA and DHA that are critical to human nutrition. With respect to natural variations in oil composition, GOED is concerned about defining oils by their fatty acid profiles: such an approach ignores the reality of environmental changes. Fatty acid profiles of short lifespan fish vary significantly in response to

www.nutraceuticalmag.com May/June 2011

environmental factors, so a static set of defined fatty acid ranges could limit the commercial trade of oils as a result of causes outside industry control. For example, anchovy oils make up the majority of the global market for omega-3 oils today, but fatty acid levels can vary significantly season-to-season and region-to-region. They have been shown to vary in response to El Niño and La Niña conditions, the time of year they are caught, the geographic region in which they are caught and even change in response to natural disasters such as earthquakes. In addition, although traditionally the fatty acid profiles in longer-living fish are less varied, GOED’s members are noticing that the fatty acid levels are beginning to fluctuate more as a result of fishery management practices.

Why a Codex Standard for Fish and Shellfish Oils? The purpose of the new work is to establish an overarching standard containing quality and compositional factors for different fish and shellfish oils. Codex has developed standards for almost all fats and oils commonly used in food. However, fish and shellfish oils are increasingly important and highly sought ingredients in an increasing variety of foods, for which no specific standard has previously been developed. Neither the Codex Standard for Edible Fats and Oils nor the Codex Standard for Named Animal Fats adequately cover the specific nature of oils from fish and shellfish. Owing to their specific composition, these oils are more sensitive to oxidation compared with other oils. Therefore, quality parameters laid down in existing standards may not be appropriate. The aims of Codex Standards are consumer protection from the point of view of health and food safety, ensuring fair practices in the food trade while taking into account the identified needs of developing countries. Establishing a Codex Standard for fish and shellfish oils containing quality and compositional factors will help to ensure fair practices in trade in these commodities. Furthermore, to ensure consumer protection, it is important to establish

quality and compositional factors for these oils. Currently, owing to the lack of an international standard, fish and shellfish oils are traded with differing levels of information, making it difficult for authorities to judge whether a particular type of oil is acceptable. In addition, because of the lack of harmonized information about fish and shellfish oils, consumers find it difficult to make informed choices.

GOED’s Position GOED supports the incorporation of the standards set forth in the GOED Voluntary Monograph into a Codex standard. The current GOED Voluntary Monograph has served as the de facto global quality standard for EPA and DHA oils for more than ten years and defines maximum levels of contaminants and oxidation in products. These standards are based on the strictest regulations and legal requirements from jurisdictions around the globe. Therefore, any product meeting the requirements of the GOED Voluntary Monograph will meet any country’s requirements. Furthermore, the GOED Voluntary Monograph does not conflict with any national or multinational regulation, which makes these standards easier to incorporate into a Codex standard. Although GOED recognizes that contaminant levels and food additives (antioxidants) are established by the Codex Committee on Contaminants and Codex Committee on Food Additives respectively, given the unique nature of the oils in question, GOED feels strongly that the contaminants outlined in the GOED Voluntary Monograph, in addition to a much wider range of antioxidants, should be incorporated into any standard developed and subsequently adopted by the CCFO.

For more information Adam Ismail, Executive Director and Harry Rice, VP, Regulatory and Scientific Affairs Global Organization for EPA and DHA Omega-3s (GOED) 1075 East Hollywood Avenue Salt Lake City, Utah 84105, USA. T. +1 801 746 1413 www.goedomega3.com

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Superba™ Krill Oil is an excellent pure source of marine omega-3 fatty acids. The omega-3’s EPA & DHA from krill are present in the highly bio-efficient phospholipid form, which provides unique health benefits. Superba™ Krill Oil is also extremely tolerable and free of repeating or “fishy burps”. Omega-3 Phospholipid EPA & DHA are important building blocks for healthy cell membranes. The ratio of EPA & DHA to other fatty acids in the membrane is called the Omega-3 Index – a strong indicator of cardiovascular health. In a recent human study, Superba™ Krill Phospholipid EPA & DHA had a significantly improved Omega-3 index compared to ordinary fish oil. AkerBioMarine is the only krill harvester that has been awarded the prestigious Marine Stewardship Council certification for its eco-friendly harvesting and traceability from sea to shelf. www.superbakrill.com superba@akerbiomarine.com Phone: +47 24 13 00 00

The superior omega-3 May/June 2011 www.nutraceuticalmag.com

legal issues

Protecting Your Products From Being Copied Abroad

ompanies invest significant amounts of time and energy to protect their technology and innovations, a common way of doing which is by obtaining patents in the United States. An issued US patent gives its owner the right to exclude others from making, using or selling their claimed inventions in the United States. Occasionally, companies find their patented inventions copied outside the United States and sold inside the United States. This article touches on the remedies available to a company or individual when its patented products are copied outside the United States. The most direct way of stopping a copycat in the United States is by proving direct infringement, which Section 271(a) of the Patent Act describes as the unlawful manufacture, use, offer to sell or selling of any patented invention within the United States, or import into the United States, during the term of the patent, without authority from the patent owner. Any liability for direct infringement must be based on acts committed within the United States. There is no single test for determining whether the point of a sale occurs in the US, so the issue depends on various factors, such as where a sale agreement is negotiated and executed, the location of the contracting parties, where the purchase orders and invoices originate, the points of payment and delivery, the shipment route and the geographically relevant contract terms. Direct infringement may also be based on the importation of infringing goods. Section 271(g) of the Patent Act also protects patented processes, to discourage companies from moving their operations overseas to exploit US process patents. A defendant cannot be held liable solely on the basis of extraterritorial conduct, only for conduct that occurs in the US. Additionally, a defendant is exempt from liability if the imported device either is materially changed by subsequent processes, or becomes a trivial and non-essential component of another product. A foreign entity may also be liable for infringement if it encourages active inducement of infringement, described in section 271(b) of the Patent Act. Active inducement requires both intent to cause infringement and affirmative acts to encourage infringement. Mere knowledge of infringement by others

www.nutraceuticalmag.com May/June 2011

is not sufficient; wrongful affirmative acts are also required. Unlike direct infringement, an inducement claim may be based solely on extraterritorial conduct, provided the plaintiff can prove direct infringement by another party. When making a claim for active inducement, circumstantial evidence of intent to infringe may be sufficient, including evidence of a failure to investigate, failure to explore design-around solutions, failure to take remedial steps and failure to seek legal advice. Testimony is also relevant, as are non-infringing uses. Courts have not found liability for inducing infringement where the products were also capable of non-infringing uses, unless the article is â&#x20AC;&#x153;good for nothing elseâ&#x20AC;? but infringement. (See MGM Studios, Inc. versus Grokster, Ltd, 545 US 913 [2005]). If a defendant still cannot be held liable, a plaintiff may establish liability for contributory infringement under section 271(c), if the plaintiff has first proved direct infringement by another party. Section 271(c) makes it unlawful to sell, offer to sell or import into the United States with knowledge that the component was specially made or adapted for use in an infringing product or method. An exemption is made for staple articles of commerce capable of substantial non-infringing use, but such use must be more than occasional, far-fetched, impractical, experimental or hypothetical. If proving infringement based on any of the theories above is too difficult or not an option, many patent owners opt to forgo damages and instead seek an exclusion order to bar the goods from American markets through International Trade Commission proceedings. ITC proceedings are a relatively quick and effective way of keeping infringing products out of the United States. However, if recovering compensation is a plaintiffâ&#x20AC;&#x2122;s priority, patent owners faced with an extraterritorial violation of their rights should not rule out the possibility of recovering damages based on the theories set forth above.

For more information Steve P. Hassid and Sophia Sarwar Silicon Edge Law Group LLP Tel. +1 310 634 1717 steve@siliconedgelaw.com

Steve P. Hassid

May/June 2011 www.nutraceuticalmag.com

opinion

Healthier Foods, Healthier People, Healthier Business The premise that healthier foods result in healthier individuals suggests that an aim of society is to improve the health of its citizens through diet. If this is the case, the purpose of any health claim legislation should be to assist companies to educate consumers about the positive connections between food and health. However, if regulation rather than education is the aim of health claims legislation, it must be assumed that healthier foods have the potential to harm individuals and that their use must be restricted or controlled by society to protect its citizens.

positive spiral, in which healthier foods result in healthier people and businesses, could be stimulated by European society. The establishment of EFSA (the European Food Safety Authority), however, has disrupted this chain of events and led to a regression. The consequences now become apparent: a system has been established in which negative publicity surrounding health claims rulings serves to destroy consumer demand, and an impenetrable health claims system depletes business opportunities. The end result of this is to decrease demand for innovative products and ingredients, effectively killing science and research. The consequences of a poor diet include obesity, diabetes, heart attacks and strokes. These are the principal health issues damaging the well-being both of individuals and the welfare system, which is unable to cope with the increasing costs of treating diet-related illnesses. It is no accident that the current highest selling medicines are those treating obesity, type II diabetes and high cholesterol levels.

The Problem Faced Unhealthy foods and consumer ignorance concerning the direct connection between diet and health, combined with a system in which society prefers to medicate rather than educate.

The Solution Offered We must counter the negative trend with preventive measures such as healthier foods and wide-reaching education, and to attempt

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to intercept the consumer before serious health issues arise. In the context of the Impossible Cost Pyramid model, functional foods and nutraceuticals can serve both preventive and agenda setting purposes for society as a whole (Figure 1). Their promotion and use initiates a positive spiral that begins when new nutritional science attracts entrepreneurs, who then create innovative products that attract early adopter consumers. As part of this scenario, producers educate both retailers and consumers by way of products and health claims, and there is a positive co-operation between science and health authorities. It is important to note that this co-operation is crucial to integrating healthier eating into the lifestyle of the mass-market consumer, who is reluctant to change his/her habits unless fully supported and sanctioned by wider society. The role of the media is a decisive factor in public trust regarding healthier eating; we all know how bad publicity can make or break confidence in a brand or a health ingredient. This publicity is usually constructed around the verdict of authorities or members of the scientific community: the attitude of governmental stakeholders will directly influence the majority of consumers. Initially, EFSA established a system of regression in the scientific arena by announcing that it would be scrutinizing all new non-vitamin products, meaning that although vitamins are approved probiotics, antioxidants etc. are not. This is not the limit of the legislation’s effect; as an authoritative institution conducting

this scientific discussion in the public domain, it has had a negative impact on public health. For example, the news that probiotic health claims were denied approval was reported in the media and generated confusion and distrust among mass-market consumers. This effect was not limited to specific brands but extended to probiotic products in general and damaged the reputation of health foods as a whole. We need only look to Denmark’s history, where strict regulations have made functional food marketing impossible, to perceive the consequences of a negative approach to functional foods. The legislation has resulted in a population that is less educated about healthy eating and therefore less motivated to change its eating habits. This has contributed to health issues that result in an average life span that falls far short of those of its Scandinavian neighbours. Needless to say, without a home market there are no new innovative Danish functional food companies: Danish policy has stimulated neither public nor industrial health.

A Positive Spiral Demands Deregulation and Education Let us now switch our attention to Finland and Sweden, where a liberal government approach in the late ’80s and early ’90s stimulated the development of the nascent functional foods industry. Interestingly, the success factors were the same as those that laid the foundation for those countries’ successful mobile phone industries. Mobile phones and functional foods

opinion

Cost The Bill Medical Care • Treatment • Medication • Surgery • Care

Medicine

Prevention • Healthy lifestyle information • Supplements • Functional foods • Choice of foods

Food

Figure 1: The impossible cost pyramid. The increasing medical cost of lifestyle-related diseases.

are both relatively new categories that occupy a position between older and more established ones; mobile phones are technologically situated between telephones and radio; functional foods between food and medicine. In both cases, the deregulation of old structures was necessary to open up space for new technologies and stimulate the innovation that created new companies. The deregulation of radio frequencies to allow public mobile networks allowed the quick development of the mobile phone industry in Sweden and Finland. Ericsson and Nokia

possessed an advantage and could begin to generate consumer demand for the new mobile phones that itself stimulated the growth of a whole innovative industry. This industry, in turn, could drive money back into research and development and a whole new value chain was thus established. Similarly, deregulation between that which was considered to be food and that which was labelled pharmaceuticals created the possibility for functional food development in Sweden and Finland. We now play host to a

growing functional foods industry that is fuelled by domestic demand from an informed and interested consumer, with the potential to export to other markets. We have created a positive events chain in which healthier foods lead to healthier consumers and healthier business. However, we must now comply with EFSA regulations and may, as a result, be forced to implement a regressive system. Questions must be asked! Who benefits from this legislation and to what extent do consumers really need to be protected from misleading claims. After all, healthier foods are not associated with damaging side-effects or death by overdose. Why, therefore, should they be regulated in the same way as pharmaceuticals? In addition, if consumers are deemed able to decide for themselves, we must question the extent to which health claims actually add to the consumer understanding of products: those who understand them do not need them. Those who need them fail to understand them.

For more information Peter Wennström President and Expert Consultant HealthyMarketingTeam Tel. +44 207 814 1944 www.healthymarketingteam.com

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functional ingredients

The Power of Omega-3 Phospholipids Omega-3 fatty acids from Superba Krill Oil show increased bioavailability compared with triglyceride omega-3s.

ietary supplementation with the long-chain omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has gained significant interest as a result of several associated health-promoting benefits. Not only were both EPA and DHA shown to be essential in early retinal and brain development, but were also identified as promoting cognitive and immune system functions and linked to the prevention of cancer and cardiovascular diseases. The human body is limited in its ability to produce EPA and DHA; the intake of these fatty acids must therefore be augmented through the diet. Although omega-3 fatty acids may be obtained through the consumption of seafood, dietary supplements are a reliable alternative or addition.

Krill: An Abundant and Sustainable Source of Nutrition One rather novel source of omega-3 PUFAs is krill oil extracted from Euphausia superba, an Antarctic krill species. Krill are shrimp-like invertebrates that live in huge swarms and feed on microscopic algae. These algae are able to produce omega-3 fatty acids, which accumulate in the eggs and body of krill and may consequently be extracted in krill oil. Moreover, algae are capable of synthesizing the powerful antioxidant, astaxanthin, a carotenoid that is subsequently taken up by krill and protects the PUFAs from oxidation. It is also the reason for the characteristic red colour of krill oil. The krillâ&#x20AC;&#x2122;s place at the bottom of the food chain and its clean habitat prevent the accumulation of contaminants that are often found in marine life higher in the food chain. Krill is one of the most abundant species on Earth with a biomass of approximately 500 million tonnes. Krill harvesting is restricted to 4 million tonnes by the Commission for the Conservation of Antarctic Marine Living (CCAMLR) to ensure sustainability and prevent a damaging impact on the availability of krill for whales, birds, seals or any other species from occurring. The current annual catch of 200,000 tonnes per year from all krill fisheries is far

Figure 1: Graphical illustration of (A) phosphatidylcholine and (B) a triglyceride.

below this margin.

Krill Oil: Rich in Omega-3 Phospholipids Most importantly, the majority of the omega-3 fatty acids EPA and DHA found in krill oil are bound to phospholipids, whereas other marine oils confine these to triglyceride or ethyl ester forms; the proportion of phospholipids in krill oil is approximately 40%. There are several different types of phospholipids and EPA and DHA are particularly rich in phosphatidylcholines (PC). A study describing the contents of Superba

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Increased Bioavailability of EPA and DHA Studies have demonstrated that increased EPA/DHA blood levels are associated with health-promoting benefits in humans; the bioavailability of these omega-3 fatty acids in the blood is therefore of great importance. ‘Bioavailability’ accounts for the quantity of a substance that reaches the blood and describes the absorption and survival rate of the substance in the body. Two recent human intervention studies investigated whether the molecular form (phospholipid versus triglyceride) of omega-3 fatty acids is of importance for the bioavailability of EPA and DHA in blood plasma.2,3 The study, performed by Kevin C. Maki and coworkers at the Provident Clinical Research and the Meridien Research Centers, was set up as a randomized, double-blind, parallel arm trial. Within this setup, 76 overweight and obese men and women were randomly distributed into three groups to take Superba krill oil, fish oil or olive oil for 4 weeks. To avoid any influence, the supplementation administered was unknown to both the study subjects and the researchers. Although the received daily amount of EPA was similar in the krill oil and fish oil group, the DHA quantity was approximately half as much in the krill oil group compared with the fish oil group. Nevertheless, at the end of the study period, plasma analysis showed that the mean EPA concentrations were higher in the krill oil group compared with the fish oil group. The mean DHA concentrations were similar in both groups. Both sources of omega-3 fatty acids were safe, generally well tolerated and significantly increased plasma EPA and DHA levels compared with the control group. Most importantly, krill oil supplementation (2 g/d) resulted in increased plasma EPA bioavailability and resulted in equal bioavailability in the case of DHA, but at half the dosage when compared with fish oil.2 Overall, after dose adjustment, it was seen that the total increase of EPA and DHA in the plasma of the subjects who received Superba krill oil for 4 weeks was 24% higher than the subjects who received fish oil (Figure 2). The second study, undertaken by researchers at Akershus University College and University of Oslo, Norway, investigated whether a lower dose of EPA and DHA provided in phospholipids, compared with omega-3 fatty acids provided in triglycerides, showed equal bioavailability of these fatty acids in plasma. In this study, 113 subjects with normal or slightly increased total blood cholesterol and/or

triglyceride levels were randomized into three groups and given Superba krill oil, fish oil or a placebo for 7 weeks. The daily supplementation of total EPA and DHA was approximately 37% less in the krill oil group than in the fish oil group. The results showed that dietary omega-3 administration led to a similar increase in plasma omega-3 fatty acids in both the krill and fish oil groups compared with the control group. These findings suggest that a lower dosage of EPA and DHA in phospholipid form is required to obtain plasma EPA and DHA levels comparable with the triglyceride form of omega-3 supplementation. After adjusting the EPA and DHA levels to the daily dose given, the results from the krill oil group suggest an impressive 45% higher total EPA and DHA plasma level than that present in the fish oil group after 7 weeks of administration (Figure 2). Moreover, the subjects with the highest baseline values of triglycerides further benefited from krill oil supplementation and showed decreased plasma triglyceride levels. Additionally the HDL-cholesterol/triglyceride ratio, a risk predictor for heart disease, was significantly decreased after Superba krill oil administration, but not after fish oil treatment. These two human clinical studies demonstrate that the intake of Superba krill oil is more potent than fish oil in increasing total plasma EPA and DHA values. Their results suggest that there is a higher bioavailability of omega-3 fatty acids bound to phospholipids than in the triglyceride-bound omega-3s found in fish oil. Thus, if managed carefully, krill can be a rich and sustainable source of omega-3 fatty acids that are important for human health.

50 % increase of plasma EPA and DHA after krill oil compared to fish oil intake

krill oil has found EPA and DHA to be present in most of the 69 identified choline-containing phospholipid classes.1 In PC, two fatty acid chains are attached to a glycerol group that is connected to choline over a phosphate group (Figure 1A); this structure enables the formation of phospholipid bilayers, which are essential for the structure of cell membranes in all life on Earth. Dietary phospholipid carriers might facilitate the transportation of omega-3 fatty acids through the body and its subsequent integration into cell membranes. As an integral part of cell membranes, EPA and DHA have the ability to influence membrane fluidity, the associated signalling processes and other metabolic parameters in the cell. By contrast, in the triglyceride form, three fatty acid chains are attached to a glycerol group (Figure 1B). Dietary triglycerides have physiological functions in the body that differ from those of phospholipids, being used principally as an energy source or to store energy in fat tissues. In addition, there is a difference in the digestion and absorption of phospholipids and triglycerides in the small intestine. Omega-3 fatty acids and lyso-PC can be absorbed in the gastrointestinal system following the digestion of phospholipids by enzymes called lipases. Omega-3s in triglycerides are insoluble in water and their absorption depends on bile salts and enzymes in the small intestine. The solubility of krill oil phospholipids in water has the advantage of decreasing the digestive discomfort sometimes seen with omega-3s provided in triglyceride form.

40 30 20 10 0 4 weeks

7 weeks

Figure 2: Percentage increase in total plasma EPA/DHA after 4 and 7 weeks of Superba krill oil supplementation compared with fish oil (values have been dose adjusted). 2,3

References 1. B. Winther, et al., “Elucidation of Phosphatidylcholine Composition in Krill Oil Extracted from Euphausia superba,” Lipids 46(1), 25–36 (2010). 2. K.C. Maki, et al., “Krill Oil Supplementation Increases Plasma Concentrations of Eicosapentaenoic and Docosahexaenoic Acids in Overweight and Obese Men and Women,” Nutr. Res. 29(9), 609–615 (2009). 3. S.M. Ulven, et al., “Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers,” Lipids 46(1), 37–46 (2011).

For more information Henrik Traaholt Business Director and Brand Manager Aker Biomarine Antarctic AS Tel. +47 2413 0122 henrik.traaholt@akerbiomarine.com www.akerbiomarine.com

May/June 2011 www.nutraceuticalmag.com

functional ingredients

Chia Seed: The New Omega-3 Powerhouse Many of us were first introduced to chia seeds as the primary ingredient in Chia Pets, a popular 1980s toy in which chia seeds sprouted over clay animal figurines, bringing the animals “to life” with a green covering. Nowadays, chia seeds are bringing food and beverage products to life in a different way — namely through their functional food benefits. In addition, they were officially granted novel food approval in October 2009 by EFSA (the European Food Safety Authority). Chia seeds have the potential to boost both the nutritional value of foods, as well as add texture and stability components. This article will serve as a broad overview of the culture, nutrition, health benefits, food applications, sourcing and manufacturing considerations and media coverage surrounding chia seeds.

hia seeds (Salvia hispanica) appear natively in both Mexico and Guatemala, although they are now also cultivated in Australia, Bolivia, Argentina and Ecuador.1 They typically appear as small ovals with a diameter of 1 mm and are mottle-coloured with brown, gray, black and white with a mildly nutty flavour. Chia was harvested and eaten by the Aztecs in preColumbian times. It was a significant staple in the diet of Mesoamerica and an important source of nutrition for warriors on long hunts … until the Spanish conquest. It is reported that once the conquistadors saw the relationship between chia seeds and religious ceremonies, they quashed the production and consumption of this special seed in an effort to transition the Aztecs to the new European ways of life.2

Nutrition Chia seeds boast a vast array of interesting nutritional advantages compared with other seeds or grains. Perhaps the most compelling nutritional feature of chia seeds is their natural content of omega-3 fatty acids, in the form of ALA (alpha linolenic acid). Omega-3s (specifically EPA/DHA) are well known for their anti-inflammatory health benefits, particularly in cardiovascular health. EPA/DHA are marinesourced; ALA is plant-sourced. ALA can be converted to EPA/DHA at an estimated rate of 0.2–15%.3 Using these conversion rates, chia seeds can offer as much EPA/DHA as other common sources of these omega-3s on a total weight basis.4 Chia seeds also offer advantages compared with other common

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sources of omega-3s (fish oil, algae oil and flax seed) in that chia seeds have a long history of human consumption, are low in saturated fats, have no cholesterol, have no antinutritional factors, are high in natural antioxidants and do not impart any fishy flavours. Chia seeds contain approximately 20% protein by weight, which is more than other common grains (which can range from 6–17%). Additionally, the protein in chia seeds is a complete protein, containing all the essential amino acids. This makes it an ideal protein choice for vegetarians/vegans who need to be extremely diligent about pairing other grains together to get their essential amino acids. Chia seeds contain about 27% fibre by weight, which is also more than other common grains (which can range from 3–18%). The fibre in chia seeds is roughly 12% soluble and 88% insoluble. This specific fibre make-up offers some interesting food application benefits, to be discussed later in this article. There are a myriad of antioxidants in chia seeds, including chlorogenic acid, caffeic acid, myricetin, quercetin and kaempferol.5 Chia seeds have an advantage compared with flax seeds in that they can be ground without as much risk of rancidity of the omega-3s because of the naturally high antioxidant content. In fact, it is reported that ground chia can be stored without adverse organoleptic problems for up to one year. Additional nutritional features of chia seeds include being gluten-free, having no cholesterol and being very low in sodium. It is interesting to know that black chia seeds may have a slightly

higher antioxidant level than white chia seeds (for example, only dark chia seeds have the additional antioxidant, quercetin); otherwise, there is not really any significant difference in the nutritional value between colours. It is important to note that chia seeds grow as a mixture of black and white chia seeds (about 90% versus 10%, respectively), and hence it is very difficult and expensive to separate out specific colours. The factor that can influence nutrition even more than colour tends to be the environment in which it is grown (that is, cooler climates produce seeds that are slightly higher in omega-3s).6

Health Benefits Chia seeds can most notably support cardiovascular health, with their potent concentration of omega-3s and antioxidants.7 However, they can also be used to support digestive health, given their high fibre content and being gluten-free. Chia seeds can also be an integral component in a diet for weight management, as the soluble fibre helps to create a feeling of satiety.

Marketing Claims Although chia seeds are not approved for any health claims by EFSA, incorporating them into foods positioned for the aforementioned benefits makes perfect sense and adds credibility to the relevance of a product for those proposed benefits. Additionally, certain nutrition claims may be made with chia seeds, including “source of omega-3 fatty acids,” “high omega-3 fatty acids,” “source of fibre”

functional ingredients

Chia seeds offer a very promising and innovative ingredient to consider as you renovate current products or develop brand new products. and “high fibre.” Finally, chia seeds can support the positioning of “contains natural, wholesome, simple ingredients” — a very popular trend these days!

Food Applications There are four potential forms that chia seeds can be manufactured as: whole chia seed (the way Mother Nature makes it); ground whole chia seed (theoretically makes nutrients more bioavailable, but this is not proven and may not be necessary); chia flour (de-oiled, keeps the fibre, loses the beneficial omega-3s); and chia oil (keeps the omega-3s but loses the fibre, protein and antioxidants). Chia seeds have a significant percentage of soluble fibre, which makes for an interesting chia gel when they are mixed with water in a 1:6–1:8 ratio. This gel consistency can be used to create gelatinous foods such as porridges, puddings, smoothies and the like. In fact, the mucilaginous aspects of the seeds in a liquid could make for a very healthy alternative or substitute for some oil or eggs in various cooking (cake) recipes or salad dressings.8 Chia flour can be incorporated into baked goods such as breads, cereals and crackers or these foods can be topped with whole chia seeds. The seeds can also be added as a topping to salads, soups and yoghurts.

Sourcing/Manufacturing Most of the chia seed growers and harvesters in South America and Mexico do not incorporate a sterilization process to guarantee a pathogen-free product.

Hence, it is very important to ensure a clean, safe product by sourcing your chia seeds from a reputable ingredients supplier. For example, BI Nutraceuticals, which has been sourcing these types of ingredients for more than 35 years, guarantees very high quality ingredients with comprehensive certificates of analysis, a proprietary steam sterilization process known as ProtexxHP and a facility that has achieved SQF, QAI, Halal and Kosher certifications. As finished goods manufacturers begin to incorporate new ingredients into new or existing products, it is important to minimize any downtime or quality issues by carefully selecting a reputable ingredients supplier.

Media Attention Chia seeds have such a wonderful story that they have become a more regular highlight in leading nutrition-focused magazines, such as Oprah Magazine, Vegetarian Times and Trail Runner Magazine. Chia seeds have also been reviewed in The Huffington Post and The Saturday Evening Post. Both Dr Andrew Weil and Dr Oz recommend them as a health food. In summary, chia seeds offer a very promising and innovative ingredient to consider as you renovate current products or develop brand new products. There are so many great attributes of chia seeds to meet a variety of popular functional health benefits, including cardiovascular health, digestive health and weight management. It really should be an option high on your list to explore!

References 1. U nited States Department of Agriculture, “ Salvia hispanica L.,” Germplasm Resources Information Network (www.ars-grin.gov/cgibin/npgs/html/taxon.pl?313893) accessed 1 April. 2. R . Ayerza and W. Coates, Chia (The University of Arizona Press, Tucson, Arizona, USA). ISBN: 0-8165-2488-2. 3. P .M. Kris-Ehterton, et al ., “Fish Consumption, Fish Oil, Omega-3 Fatty Acids and Cardiovascular Disease,” Circulation . 106, 2747–2757 (2002). 4. h ttp://nutritiondata.self.com 5. M .S. Taga, E.E. Miller and D.E. Pratt, “Chia Seeds as a Source of Natural Lipid Antioxidants,” Journal of the American Oil Chemists’ Society 61, 928–931 (1984). 6. R . Ayerza and W. Coates, Analyses Completed by an ISO 9000 Certified Laboratory (unpublished), www.EatChia.com (2006). 7. V. Vuksan, et al., “Supplementation of Conventional Therapy with the Novel Grain Salba (Salvia hispanica L.) Improves Major and Emerging Cardiovascular Risk Factors in Type 2 Diabetes: Results of a Randomized Controlled Trial,” Diabetes Care 30, 2804–2810 (2007). 8. R . Borneo, A. Aguirre and A. Leon, “Chia ( Salvia hispanica L.) Gel Can Be Used as Egg or Oil Replacer in Cake Formulations,” J. Am. Diet Assoc. 110, 946–949 (2010).

For more information Angela Dorsey-Kockler, RD, MBA Product Manager BI Nutraceuticals www.botanicals.com

functional ingredients

The Heart of the Matter

As cardiovascular diseases become an ever-increasing global problem, food ingredients with heart health benefits look set to grow in importance. Supported by new clinical trial data, one olive leaf extract looks particularly interesting.

rom the initial discovery of the comparatively low heart attack incidence across the Mediterranean, the positive effects of the socalled “Mediterranean Diet” have been well publicized. A principal constituent of this diet is olive oil. Its unsaturated fatty acids and antioxidant-rich ingredients such as oleuropein provide protection against cardiovascular diseases. However, what most people don’t realize is that this health-promoting substance is contained not only in the fruit of the olive tree, but also in the leaves, where it is in fact found in greater concentrations.

The Olive Leaf: An Ancient Remedy The olive tree (Olea europaea L.) is one of the world’s oldest cultivated plants, and still possesses a strong symbolic connection to peace and strength. People have used olive oil and eaten the leaves since ancient times, especially in Mediterranean cuisine. The leaves have a history of traditional use in combating high blood pressure and diabetes; for instance, Yemeites were reported as never suffering from diabetes because of their habit of eating or chewing olive leaves. Today, olive leaves are principally used as a spice and classified as a flavouring in a Council of Europe publication.1 Olive leaf tea is commercially available in Europe and

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is recommended in at least one traditional medicinal encyclopaedia for use in high blood pressure.2 Scientific data also supports the efficacy of an olive leaf extract that can be used in a wide variety of functional foods and dietary supplements. Produced by Frutarom Switzerland, Beneola has been shown in clinical trials and in vivo studies to support the cardiovascular system and a healthy heart.

a balanced diet that includes five daily servings of fruit and vegetables, coupled with increased physical activity. Most people are aware of this advice, but very few follow it, leaving healthcare systems burdened with the huge cost of treatment. Thus, there is enormous potential for dietary supplements and functional foods with cardiovascular health benefits to help reduce food costs and improve the health of populations worldwide.

A Growing Problem

A Natural Route

The World Health Organization (WHO) lists cardiovascular diseases (CVDs) as the number one cause of death globally. In 2004, an estimated 17.1 million people died from CVDs, mainly coronary heart disease and stroke. By 2030, WHO predicts that this figure will have risen to 23.6 million.3 Risk factors for CVDs include an unhealthy diet and physical inactivity, the effects of which may manifest themselves as hypertension (high blood pressure), raised blood glucose, raised blood lipids, weight gain and obesity. Hypertension alone already affects approximately one billion people worldwide.4 As the population ages, the prevalence of the condition is sure to increase, unless broad and efficient preventive measures are implemented. The most effective way of preventing CVDs is to adopt a healthy lifestyle, based around

Natural, plant-based herbal remedies are often preferred to pharmaceuticals as they generally cause fewer side-effects, but consumers do not always benefit from them as they should. Frutarom’s Benolea is supported by scientific data and published studies that show that it can be used to reduce risk factors associated with CVDs, such as high blood pressure and raised blood lipids. Benolea is manufactured in a PIC-GMP-certified production site, according to a multicomponent system philosophy that sees the whole of a plant’s raw material as active, rather than just its fractions or isolates. Similarly to other Frutarom extracts, Benolea is manufactured under the EFLA HyperPure patent, guaranteeing easy handling and high purity, as well as unique market positioning. Many olive leaf

May/June 2011 www.nutraceuticalmag.com

functional ingredients

Figure 1: Both Benolea and Captopril clearly lowered systolic blood pressure compared with baseline.

Figure 2: Benolea significantly reduced total cholesterol and triglyceride levels.

extracts are standardized for hydroxytyrosol, a degradation product of oleuropein with antioxidant properties. Oleuropein is a substance that’s present in the olive plant that has been shown to possess blood pressure lowering effects. However, hydroxytyrosol has no proven beneficial effect on blood pressure. Frutarom’s gentle manufacturing process preserves these benefits by preventing the degradation of oleuropein to hydroxytyrosol.

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Clinically Proven Several studies have underlined the benefits of Benolea, the latest of which compares the extract with Captopril, a pharmaceutical widely used to combat hypertension. 5 The randomized, doubleblind, double-dummy, active controlled study involved 232 participants aged 25 to 60 with stage 1 hypertension (systolic blood pressure 140–159 mmHg, and/or diastolic blood pressure 90–99 mmHg)

who were not taking any medication or were asked to stop it upon consent. A 4-week run-in period without treatment was followed by 8 weeks of treatment with either one 500 mg Benolea caplet twice a day, or one 12.5 mg Captopril tablet twice a day. After 2 weeks, if participants showed no response to Captopril, they received a double dose. Dietary advice was given to help participants manage their hypertension, and adverse events and changes in laboratory parameters (routine haematology, serum electrolytes, liver and renal function) were monitored. At the end of the study, both Benolea and Captopril had clearly lowered systolic blood pressure compared with baseline. In fact, the reduction of the systolic blood pressure in the natural treatment group including Benolea was comparable with the pharmaceutical group including Captopril (Figure 1). Regarding the lipid profile, Benolea significantly reduced total cholesterol and triglyceride levels, whereas positive effects were not observed in the Captopril group (Figure 2). The results of this clinical study reveal that Benolea not only displays the same blood pressure reducing effect in people with mild elevated values (stage 1 hypertension) as a standard antihypertensive drug, but positively influences the lipid profile of this population and is safe and well tolerated. These findings echo the results of a preliminary study in twins, which reported the benefits of Benolea in lowering blood pressure and LDL cholesterol in borderline hypertension.6 The monozygotic twins with borderline hypertension (blood pressure >120 mmHg systolic or 80 mmHg diastolic) received a daily dose of 500 or 1000 mg of Benolea in tablet form for 8 weeks or advice on a favourable lifestyle. Results confirmed a dose-dependent blood pressure lowering effect, with differences reaching maximum values of 13 mmHg systolic and 5 mmHg diastolic blood pressure (Figure 3). Accumulated data from trials indicate that a sustained reduction of 6 mmHg in diastolic blood pressure reduces the risk of stroke by about 40%.7 This study also proved that Benolea boasts an additional benefit — namely a significant reduction in LDL (Low Density Lipoprotein) cholesterol (Figure 4), increased levels of which are associated with CVDs. For this reason, LDL cholesterol is often called “bad” cholesterol. Both these results and those from the latest Captopril

functional ingredients

Figure 3: Benolea yielded a reduction in blood pressure with time.

References

Figure 4: Benolea resulted in a significant decrease in LDL cholesterol.

study confirm the findings of an earlier in vivo study on hypertensive rats, which demonstrated a significant reduction in blood pressure with Benolea, in both a preventive and a curative capacity.8

Products for a Healthy Heart On the basis of such sound scientific data, Benolea enables manufacturers to offer products with proven beneficial effects on heart health. The product is stable in film-coated tablets and a valuable dosage form for food supplements.

Furthermore, it is clearly water-soluble and can be used in still or carbonated drinks in appropriate dosages, taking into account national food regulations. Thanks to its heart health promoting properties and its excellent tolerance, Benolea can be seen as a valuable ingredient in a healthy diet. With the prevalence of CVDs rising across the globe, this represents a huge opportunity for manufacturers of dietary supplements and functional foods to offer clinically supported products to a growing population group.

1. Council of Europe Publishing, Natural Sources of Flavourings, Report No. 2 (2007) pp 221–222. 2. W. Wurzer, Die Grosse Enzyklopädie der Heilpflanzen (Neuer Kaiser Verlag GmbH, Klagenfurt, Austria, 1994) pp 402–403. 3. World Health Organization, Cardiovascular Diseases (CVDs) Fact Sheet No. 317 (January 2011). 4. National Institutes of Health, “National High Blood Pressure Education Program, The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (NIH Publication No. 03-5233),” www. nhlbi.nih.gov/guidelines/hypertension/express.pdf (Bethesda, Maryland, USA, 2011). 5. E. Susalit, et al., “Olive (Olea europaea) Leaf Extract Effective in Patients with Stage-1 Hypertension: Comparison with Captopril,” Phytomedicine 18(4), 251–258 (2011). 6. T . Perrinjaquet-Moccetti, et al., “Food Supplementation with an Olive (Olea europaea L.) Leaf Extract Reduces Blood Pressure in Borderline Hypertensive Monozygotic Twins,” Phytother. Res. 22(9), 1239–1242 (2008). 7. National Stroke Association: Risk Reduction Methods: www.stroke.org/site/ PageServer?pagename=RISKMETH. 8. M.T. Khayyal, et al., “Blood Pressure Lowering Effect of an Olive Leaf Extract (Olea europaea) in L-NAME Induced Hypertension in Rats,” Drug Res. 52(11), 797–802 (2002).

For more information Karin Wrzesinski Product Manager Health Frutarom Switzerland Ltd kwrzesinski@ch.frutarom.com www.frutarom.com

May/June 2011 www.nutraceuticalmag.com

Roquette the natural partner Visit us at VITAFOODS 10-12 May Stand: 774

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Innovative formulation: looking for a natural partner? Try Roquette. Our comprehensive range of ingredients and actives – such as NUTRIOSE®, NUTRALYS® and LYCATAB® Mineral – is not just sourced from renewable raw materials. Of exceptional purity and quality, it’s also backed by R&D with a significant track record of commitment to nutrition.

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functional ingredients

The Facts Behind the Fibre Scientific support for a soluble fibre.

s a patented dietary fibre that’s recognized by both regulatory and scientific bodies for its positive effects and health benefits, NUTRIOSE has much to offer the food industry. Derived from vegetal sources, traditional dextrinization is used to obtain NUTRIOSE FB and NUTRIOSE FM from wheat starch and non-GMO corn starch, respectively. The resulting product displays resistance to digestion by small intestine enzymes, causing it to be of special nutritional interest as a dietary fibre. These characteristics, combined with its ease of use and neutral taste means the possibilities for NUTRIOSE are virtually limitless (Figure 1). NUTRIOSE’s “fibre effect” benefits are derived from it being fermented in the large intestine and have been assessed according to the following: Digestion pattern: Animal tests show that only about 15% of NUTRIOSE is digested in the small intestine; about 85% reaches the colon (Figure 2). Fermentation rate: Several clinical trials with NUTRIOSE indicate prolonged fermentation in humans throughout the colon. This is marked by a prolonged increase in breath hydrogen excretion, indicating long-lasting fermentation; 75% of the fraction in the colon is fermented and 10% is excreted.

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May/June 2011

Figure 1: NUTRIOSE, the reliable fibre.

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functional ingredients

Modulation of the colonic environment: The following extracts from animal or clinical studies demonstrate the modulation of colonic parameters by NUTRIOSE. • Metabolite production: A significant increase in breath hydrogen excretion in humans and a significant increase in the production of short-chain fatty acids.1–3 • Acidification of faecal content: Decreased faecal pH in humans after the consumption of NUTRIOSE. • Enzyme activity modulation: Increased α- and ß-glycosidase activity.4 • C olonic flora modulation: A 14-day consumption trial of 8 g of NUTRIOSE results in a significant increase in Bacteroides and a significant decrease in Clostridium perfringens (Figures 3 and 4). 1 • Impact of the fibre effect on health: Several clinical studies have demonstrated that the consumption of NUTRIOSE is significantly correlated with a modulation of the colonic environment and is beneficial for the health of the host.

Safe Benefits The guarantee of a total fibre content that is both high and stable is a key element in the promotion of a dietary fibre. NUTRIOSE is able to perform well on both counts. It provides excellent stability under the intense temperatures and low-pH production conditions that occur during drink, cake-, biscuitand bread-making; and, according to the AOAC method, it contains up to 85% dry substance. NUTRIOSE’s simplicity of use also means that no formulation, use or stability constraints are imposed at any time during the shelf-life of the finished product. Furthermore, these benefits have been proven by in-house studies commissioned by Roquette. • Stability at different pHs: NUTRIOSE is stable at a very broad range of pH, down to pH 2.5 • Stability with time, even in acid conditions: A study has shown the 90-day progression of the molecular mass Mw (expressed in %/Initial Mw) of a pH 2.7 solution of NUTRIOSE and of two other soluble fibres at 10% dry matter placed at 23 °C.6 The aqueous NUTRIOSE solution was seen to be stable in an acid medium for a long period, unlike some other soluble fibres that hydrolyse with time. • Temperature stability: NUTRIOSE can be integrated into numerous preparations before or after cooking, even during extreme thermal treatments such as pasteurization, UHT treatment, etc.

Total Transparency Showing unrivalled tolerance, several short- and long-term clinical studies in humans have confirmed that NUTRIOSE does not induce any side-effects at 45 g/d.7 Similarly, Roquette solubility tests have demonstrated the outstanding rate at which it is dispersed in water at room temperature.

Conclusions

Figure 2: Fermentation and excretion of NUTRIOSE in the colon.

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May/June 2011

Fibre, recognized as part of a healthy diet, has a key role to play in human health. As a reliable, soluble fibre boasting proven highperformance characteristics, NUTRIOSE suits the needs of food producers that place nutrition and dietary balance at the core of their development strategy.

Nutrition

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9 8.95 Log CFU/g

8.9 8.85 8.8 8.75 8.7 8.65

Before

After

*: p<0.05

Figure 3: Bacteroides before and after a 14-day consumption trial of 8g/d of NUTRIOSE.

3.55 Log CFU/g

3.5 3.45 3.4 3.35 3.3 3.25

Before

After

*: p<0.05

Figure 4: Clostridium perfringens before and after a 14-day consumption trial of 8g/d of NUTRIOSE.

References 1 E.G.H.M. van den Heuvel, et al., “Short-Term Digestive Tolerance of Different Doses of NUTRIOSE FB, a Food Dextrin, in Adult Men,” Eur. J. Clin. Nutr. 58, 1046–1055 (2004). 2 M. Berard, et al., “Prebiotic Effects of NUTRIOSE: A Review,” presented at the International Congress of Nutrition (Bangkok, Thailand, 4–9 October 2009). 3. C. Lefranc-Millot, et al., “Effects of a Soluble Fibre with Excellent Tolerance, NUTRIOSE 06, on the Gut Ecosystem: A Review,” in K. Ahlgren (Ed.), Proceedings of the Dietary Fibre Conference (Helsinki, Finland, 12–14 June 2006) pp 143–144. 4. E.G.H.M. van den Heuvel, et al., “Dietary Supplementation of Different Doses of NUTRIOSE FB, a Fermentable Dextrin, Alters the Activity of Faecal Enzymes in Healthy Men,” Eur. J. Nutr. 44, 445–451 (2005). 5. Roquette in-house study. 6. Roquette in-house study. 7. W. Pasman, et al., “Long-Term Gastrointestinal Tolerance of NUTRIOSE FB in Healthy Men,” Eur. J. Clin. Nutr. 60(8), 1024–1034 (2006).

For more information Emily Lauwaert Marketing Communication Manager ROQUETTE Group Nutrition Business Unit Tel. +33 3 2163 3600 foodbusiness@roquette.com www.roquette-food.com/www.nutriose.com

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brain health

Bioenhanced Natural Palm Tocotrienol Complex and its Role in Neuroprotection After coronary heart disease, stroke is the most common cause of death in the EU, resulting in roughly 508,000 deaths a year.1 This makes it a major global public health concern. Not only does it prematurely claim productive lives, many stroke survivors become disabled and require longterm care and rehabilitation, thus placing a large burden on healthcare systems.

troke survivors often suffer physically from loss of speech, co-ordination, mobility and cognition. The majority of them must also deal with the emotional stress and depression that results from their loss of independence. The prevalence of stroke rises in older age groups. According to the European Heart Network, stroke is estimated to cost the EU economy more than â&#x201A;Ź38 billion a year, roughly 49% of which results from direct healthcare costs, 23% to productivity losses and 29% to the informal care of stroke victims.

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Prevention of Stroke Stroke risk may be reduced by partaking in regular physical activity, refraining from smoking and maintaining a healthy diet. Although prescription medicines are regularly recommended for the prevention of stroke, including cholesterollowering drugs, anticoagulants and antihypertensives, they often produce undesirable side-effects and require strict adherence to dosage. Researchers have been seeking natural alternatives for preventing the onset of stroke and, during the past two decades, studies have

revealed the potential benefits of palm tocotrienol complex in supporting brain cell survival in a stroke-like condition. Although palm tocotrienol complex is categorized as a vitamin E, its neuroprotective effect is not shared by other members of the vitamin E category â&#x20AC;&#x201D; such as alpha-tocopherol.

What is Palm Tocotrienol Complex? There are eight structurally related compounds in the vitamin E family â&#x20AC;&#x201D; four tocotrienols and four tocopherols. Different numbers and positions of methyl

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brain health

Tocotrienol’s unsaturated sidechain allows more efficient penetration into the brain.

groups present on the chromanol head of individual molecules (“R” positions, Figure 1) distinguish each isomer by a Greek letter α, ß, γ or δ. Tocotrienol and tocopherol differ only at the sidechain; tocopherol has an all-saturated side tail whereas tocotrienol possesses three double bonds in its tail. Studies suggest that the unsaturated state of the side tail allows tocotrienol to engage in significantly different biological activities to tocopherol. Unlike tocopherol, tocotrienol is naturally scarce; only crude palm oil (Elaeis guineensis) contains the highest level of all four tocotrienols in addition to some alphatocopherol. Tocomin is a natural tocotrienol/ tocopherol complex derived from virgin crude palm oil, using a patented mild extraction process that ensures the maximum preservation of phytonutrients. It contains predominantly full spectrum tocotrienols and other phytonutrients such as tocopherols, plant squalene, phytosterols, co-enzyme

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May/June 2011

Q10 and mixed carotenoids that are naturally extracted alongside tocotrienols.

Scientific Evidence of Tocomin Neuroprotection Tocotrienol confers neuroprotection through two main functions: Through powerful antioxidant activity: The brain is highly susceptible to oxidative damage because of its continuous high oxygen consumption, which occurs regardless of degree of activity. Furthermore, the high lipid content of the brain also causes it to be susceptible to lipid peroxidation in an antioxidant poor environment. Tocotrienol is 40–60 times more effective than α-tocopherol in protecting brain cells from peroxidation.2 The higher efficiency of α-tocotrienol in protecting brain cells from oxidative damage could result from the following: • the unsaturated sidechain of tocotrienol allowing more efficient penetration into

tissues that have saturated fatty layers, such as the brain and liver • tocotrienols being recycled/regenerated more effectively to be reused • a stronger disordering of cell membrane and higher mobility allowing tocotrienols to interact more efficiently with lipid radicals. Through mechanisms other than antioxidant function: The non-antioxidant mechanism occurs via two key molecular checkpoints: c-Src and 12-lipoxygenase. Published in the prestigious, peer-reviewed American Heart Association journal, Stroke, a study revealed that the oral supplementation of Tocomin natural full spectrum palm tocotrienol complex to spontaneously hypertensive rats led to increased tocotrienol levels in the brain. The rats supplemented with Tocomin showed more protection against stroke-induced injury when compared with controls (a nonsupplemented group). It was demonstrated that oral supplementation of Tocomin palm

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May/June 2011 www.nutraceuticalmag.com

brain health

R1 HO 6 7 R

5 8

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’

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’

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’

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’

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’

6’

’

8’

’

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Figure 1: Chemical structures of vitamin E tocopherol and tocotrienol.

tocotrienol complex acts on key molecular checkpoints (c-Src and 12-lipoxygenase) to protect against glutamate and strokeinduced neurodegeneration, and may ultimately protect against stroke in vivo.3 In another study, published in the Journal of Neurochemistry, Prof. Sen’s team determined that tocotrienols protect against stroke-induced neurodegeneration by acting as an antioxidant at higher concentrations, and providing non-antioxidant protection at lower levels.4 Neurological damage can be caused in two different ways; first, through the presence of homocysteic acid, which in excess may cause vascular and neuronal lesions associated with cardiovascular disease; secondly, as a result of linoleic

acid, a fatty acid that can directly stimulate harmful free radical activity. Fatty acids, related to stroke because of their rapid accumulation when bloodflow to the brain is prevented by a clot in a vessel, cause irreversible brain injury. To observe tocotrienol’s effectiveness, rodent neural cells were treateed with extremely low (nanomolar levels) concentrations of tocotrienol. Although these cells avoided the death associated with toxicity caused by homocysteic acid, a higher concentration of tocotrienol was necessary to reduce free radical activity and the resulting neurotoxicity caused by linoleic acid. Tocotrienol does not exhibit antioxidant properties until it reaches a

The patented SupraBio system is a self-emulsifying delivery method that provides more consistent and enhanced oral absorption of tocotrienols. www.nutraceuticalmag.com

May/June 2011

concentration that’s 10–25 times stronger than the concentration that prevented the cell death signal. Yet another related study was published in Antioxidant and Redox Signalling in which a group of women were administered with 400 mg of TocovidSupraBio soft gel capsules (formulated from TocominSupraBio) and blood samples were collected 2, 4, 6 and 8 hours after supplementation.5 Peak plasma tocotrienol levels were found to be 12–30 times higher than those levels determined necessary by earlier research to completely prevent stroke-related neurodegeneration. The patented SupraBio system is a selfemulsifying delivery method that provides more consistent and enhanced oral absorption of tocotrienols. It contains a mixture of oil and a proprietary complex of emulsifiers at an optimum ratio that will self-emulsify in the gastrointestinal tract and be followed by further reactions to generate the necessary conditions for optimal tocotrienol absorption. This novel delivery system results in a rapid and consistent absorption of tocotrienols that’s independent of dietary fat or food intake. The efficacy of the SupraBio system, which increases the rate and extent of tocotrienol absorption by up to 300%, was confirmed by a clinical study on healthy human volunteers.6

CMY

brain health

An Ongoing Clinical Trial Involving TocominSupraBio The largest ever human clinical trial on tocotrienols, examining the effects of TocominSupraBio on neuroprotection, is currently under way at the University of Science Malaysia.7 The primary objective of this clinical trial is to study early changes in the brain (white matter lesions [WML]) through the use of sophisticated magnetic resonance imaging (MRI), and to investigate the efficacy of TocominSupraBio in affecting these changes.

White Matter Lesions and Transient Ischemic Attack WML result from a transient ischemic attack (TIA), or mini-stroke, which lasts less than a day. According to the American Heart Association, the prevalence of TIA increases with age and about 15% of strokes are preceded by a TIA. Up to a quarter of patients will die within a year of suffering a TIA, which also results in a 10 year stroke risk of 18.8%.8 Recently, AF-NBT-21x14.8.pdf

3/18/11

Stroke journal accepted another NIH-funded research study by Prof. Chandan Sen.9 In this latest study, Prof. Sen and his team found that orally supplemented tocotrienol (Tocomin) at 50 mg/kg bodyweight for 13 weeks protected brain cells that had already suffered TIA against a full blown stroke. Prof. Sen is now eager to move the research forward to a full clinical trial to evaluate Tocomin’s neuroprotective effects in TIA patients.

Conclusion The improved absorption of tocotrienols and efficient delivery to vital organs, especially the neurons, is crucial to ensure that tocotrienols are available where there is greatest requirement. The potential of patented and bioenhanced TocominSupraBio in supporting neurofunction to prevent stroke is based on strong scientific evidence that supports the incorporation of natural full spectrum palm tocotrienol complex as one of the preventive measures for stroke.

References 1. E uropean Heart Network, European Cardiovascular Disease Statistics, 2008 Edition (www.ehnheart.org). 2. J .P. Kamat, et al., Neuroscience Letters 195, 179–182 (1995). 3. C .K. Sen, et al., Stroke 36, e144–e152 (2005). 4. S . Khanna, et al., J. Neurochem 98(5), 1474–1486 (2006). 5. P . Khosla, et al., Antioxid. Redox Signal. 8(5–6), 1059–1068 (2006). 6. D . Ho, et al. , US Patent 6596306. 7. C linicalTrials.gov, “Neuroprotective and Cardioprotective Effects of Palm Vitamin E Tocotrienols,” NCT 00753532 (2008). 8. A merican Heart Association, “Heart Disease and Stroke Statistics, Update at a Glance (2009), www.heart.org. 9. H .A. Park, et al., Stroke, Article in Press (2011).

For more information Dr Sharon Ling Vice President, Scientific Affairs Sales and Marketing (Europe) Carotech Ltd Tel. +44 1296 623 214 www.carotech.net

3:40:02 PM

May/June 2011 www.nutraceuticalmag.com

health management

Tobacco Withdrawal

An Innovative Nutritional Support Concept Currently, 1.3 billion people in the world smoke cigarettes or tobacco products, a number that is predicted to reach 1.7 billion by 2025. And, as a result, 4.5 million people die every year of both first and second hand smoking. The World Health Organization (WHO) identifies this as the second most prevalent cause of death in the world, responsible for the death of one in ten adults. In fact, tobacco use is a risk factor for six of the eight leading causes of death globally, including lung cancer and heart disease.

ublic health is not the only issue of concern in this matter: the fact that $96 billion is spent in the US on medical expenditures related to tobacco consumption, not to mention the $97 billion lost owing to decreased productivity, means that tobacco addiction is a serious economic burden. It has not been easy to find a solution to this problem: it is estimated that a mere 3–5% of smokers who attempt to quit without support manage to succeed for longer than 6–12 months. This figure would increase at least threefold should help be provided, whether it be pharmacological or otherwise.

Three Steps in Tobacco Withdrawal Tobacco withdrawal has been defined as a process that includes the following steps: 1 • W ithdrawal motivation, which occurs slowly and may take years or even decades • W ithdrawal itself, commonly lasting an average of 2–3 months but may fluctuate between a couple of weeks and 5–6 months • R elapse control: relapses can be induced by a number of different reasons, which are often not related to withdrawal symptoms. The fact that individuals commonly smoke as a form of stress relief causes the stress-fraught process withdrawal to be particularly difficult. With this in mind, it is very important to find means of limiting stress symptoms such as nibbling, mood swings, concentration problems, etc. This article will investigate this complex problem and outline specific solutions designed to encourage successful tobacco cessation.

Why is it So Difficult to Quit Smoking? The act of smoking a cigarette creates differing sensations in different individuals: some experience it as a stimulating process that triggers alertness and keeps them awake. Others consider it to be a relaxation device, capable of relieving their anxiety. These are some of the factors that cause smoking cessation to be difficult. Moreover, a number of worrisome questions can arise when a smoker decides to withdraw, which can result in a psychological block. Questions frequently asked of physicians demonstrate that major concerns surrounding tobacco cessation relate to weight management and mental health. Typical questions include “Why is there a risk of gaining weight when withdrawing?”

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May/June 2011

or “What can I do to not gain weight?” and “I am depressed and have quit smoking/I have already had a nervous breakdown and I’m afraid it might come back during the withdrawal period, what should I do?” It is crucial that these questions be addressed to complete successful tobacco withdrawal.

How to Reduce Withdrawal-Related Stress Withdrawal symptoms vary in their number and degree, depending on the individual. There are now numerous means of dealing with these symptoms; methodologies such as sophrology, relaxation therapy, psychological support, hypnosis and medicine intake all claim to ease the major symptoms of tobacco withdrawal. Symptoms can manifest themselves in two ways, depending on the physiological process involved. A slowdown of the dopaminergic axis leads to sadness, depression, concentration problems, lack of confidence, etc. Serotonin shortage, by contrast, may induce a shortness of temper, aggression, anxiety, nervousness, mood swings and sleeping problems. The latter of these is the most common form of withdrawal symptom experienced by individuals upon smoking cessation and is almost unavoidable in the weeks following tobacco withdrawal. Thus, it is of great importance to provide a withdrawing smoker with support and assistance in reducing stress symptoms, such as sweet nibbling. Therefore, nutritional counselling and support could be recommended to provide assistance throughout the ordeal of tobacco withdrawal. For example, consuming a product such as Lactium, which can be easily associated with a nicotine substitute, would improve outbreaks of stress symptoms and thus have a positive effect on the withdrawal process. Lactium, in development by Ingredia Nutritional scientists and research institutes since 1990, is an αs1-casein hydrolysate containing a bioactive decapeptide that boasts clinically proven relaxing properties. After years of research, it has been possible to identify a peptide (Figure 1) from a tryptic hydrolysate that has an anxiolytic-like activity.2 This bioactive decapeptide has been reported to demonstrate a benzodiazepine (BDZ)-like activity of the GABA A receptors and is involved in the same action mechanisms that cause psychoactive drugs such as benzodiazepines to be so effective. Lactium, however, has been proven to induce relaxation without the sideeffects associated with long-term benzodiazepine treatment. As mentioned above, feelings of stress are a primary effect of nicotine

strap 57 STRESS RELIEF INNOVATION * (increase)

Placebo

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Lactium *

10.0 5.0 0.0 Systolic Blood Pressure (SBP) Unpaired t-test (2 tailed)

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16.0 14.0 12.0 10.0

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8.0 6.0 4.0 2.0 0.0 Blood Cortisol Paired t-test (2 tailed): *** p < 0.005 Figure 2: Blood cortisol levels in the Lactium group showed marked decreases compared with the placebo group.

withdrawal. Ingredia Nutritional has, thanks to several clinical studies, proven that Lactium reduces the impact of the two main withdrawal symptoms related to smoking cessation. In fact, it makes tobacco withdrawal easier by reducing the urge to pick up a cigarette and limiting the weight gain caused by snacking.

Impact on Cigarette Cravings In 2000, a clinical study done on healthy human subjects at the Necker-Enfants Malades Hospital (Paris, France) demonstrated that the consumption of Lactium (1200 mg in 2 days) serves to modify some physiological variables during imposed experimental stress. 3 Haemodynamic parameters, including systolic (SBP) and diastolic (DBP) blood pressures and plasma cortisol concentration (cortisol being a steroid hormone released from the adrenal cortex in response to stress) were followed as physiological indicators of the stress state. Figure 1 shows that the percentage increases in both SBP and DBP were significantly higher in the placebo group than in the Lactium group. This is despite similar baseline values in the two groups: SBP (-31.9%) and DBP (-28.9%) Lactium group compared with the placebo. The average cortisol concentration (CC) value obtained at the end of the stress-induced period was not diminished in the placebo group, indicating that there was no efficient response to the successive stressful situations. By contrast, the CC of the Lactium group significantly decreased (Figure 2). This study

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health management

MBP response (mmHg) 16.0

15.0 14.0

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Figure 3: Lactium has a significant relaxing effect at a dosage of 150 mg/day.

provides preliminary evidence that the bovine milk α s1-casein hydrolysate displays a soothing effect in human subjects. These data were supported by the results (seen in Figure 3) of a longterm study demonstrating Lactium’s noticeable relaxing effect at a dosage of 150 mg/day. 4 Indeed, Lactium significantly reduces the mean blood pressure (MBP) response to stress from day 11 to day 31, an effect that lasts until day 43. An additional study in 2006, conducted on 63 women and based on well-being improvement statements made in 2003, revealed a significant reduction of stress-related disorders reported by volunteers. 5 The effect of Lactium on stress-related symptoms was clearly perceived by individuals suffering from chronic stress. An example of this is the lower tension levels such as anxiety, nervousness and anger that were reported by members of the Lactium group versus those who were administered with the placebo. Indeed, this reduction was reported at a rate of +37% with a daily dose of 150 mg of Lactium (Figure 4). The data presented above demonstrate that Lactium benefits from strong clinical substantiation of its efficacy in reducing stress-related symptoms. Notably, it also shows significant improvements in the tensional state that often induces cigarette cravings and the urge to “resmoke” among withdrawing smokers.

Impact on Weight Gain Another element that often weakens the motivation to cease smoking is the weight gain caused by stress-related snacking. The influence of stress on food intake is well documented: Grilo,

+105%

et al. reported that stressful life events predict eating disorder relapse following remission and Tseng, et al. , in a study on 426 Chinese immigrant women, revealed that migration-relation stress selectively increased fat intake and energy density. 6,7 Lactium assists smokers in limiting weight gain at both qualitative and quantitative levels. The previously mentioned Proclaim study demonstrates that Lactium significantly improves stress-related symptoms, including weight disorders. During this study, the subjects in the Lactium group who were questioned about the perception of their weight registered an improvement of their physical state in comparison with the placebo group (Figure 5). Moreover, in a Lactium intragroup comparison, the subjects’ perception of physical state improvement reached 115%. In 2006, a study on rats was conducted to monitor the influence of induced stress on food intake. After stress was generated through a fast period of 48 h, rats significantly increased their food intake (Figure 6, grey curve). Stressed rats that had been given Lactium (red curve), however, showed a food intake similar to the reference group (blue curve), which strongly suggests that Lactium restores normal food intake levels. Chronic mild stress also unbalances food intake and increases sweet nibbling. In an additional study on rats in 2007, Ingredia Nutritional studied the influence of induced stress on quality of food intake. During a moderate stress period, the food behaviour of the rats was seen to unbalance and they prioritized sweet products at the expense of standard food. Stressed rats that had been given Lactium, by contrast, balanced their food intake in the same way as unstressed rats. Consequently, the percentage of fat body mass strongly increases among stressed rats, whereas it remains stable and similar to the reference group among those stressed rats that had been given Lactium (Figure 7). The consumption of Lactium helps to better manage stress and thus contributes to limiting snacking and, in particular, sweet food nibbling. This is very important during a “tobacco withdrawal period” when it is essential to limit food consumption while avoiding feelings of frustration.

Conclusion Although Lactium is not a nicotine substitute, its soothing properties help to manage the stress-related symptoms caused by tobacco deprivation. The benefits from tobacco withdrawal appear very soon after cessation but also increase with time. It is

+115%

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Weight

Tensional state Figure 4: Lactium benefits from strong clinical substantiation of its efficacy to reduce stress-related symptoms.

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May/June 2011

Figure 5: Lactium group subjects questioned about their weight noted a perceived improvement compared with the placebo group.

health management

Food intake

26 24

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Stressed group

Stressed group + Lactium

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Fat mass (% body mass)

Figure 7: Percentage fat body mass strongly increases among stressed rats, whereas it remains stable and similar to the reference group among stressed rats that had been given Lactium.

thus very important for the health of smokers that they hold firm in the decision to quit smoking. By taking Lactium, they can boost results and increase their well-being thanks to optimal stress management. As a unique and 100% natural solution to stressrelated problems, Lactium helps consumers to manage both daily stress and that which is linked to tobacco withdrawal symptoms. It may be taken in conjunction with specific detoxifying products or a medical method adapted to tobacco cessation to increase the chances of a successful withdrawal. Not only can Lactium assist in supporting tobacco withdrawal, it could also be used in the withdrawal of other addictions by • limiting feelings of stress that lead to the consumption of addictive substances • limiting stress-related symptoms, notably the tensional state that arises as a result of addictive substance withdrawal • limiting the side-effects of withdrawal, such as snacking, mood swings and concentration problems. One of the many possible applications of Lactium is a specially designed chewing gum concept, formulated with the ingredient to reduce stress-related symptoms. This brand new concept has been created in combination with Gumlink, utilizing their patented bilayered compressed chewing gum, which is especially suitable as a delivery system for active ingredients. In addition to the functional benefits of Lactium, the chewing of gum in itself produces benefits such as stress relief while chewing, making the combination of the two a potent match. Therefore, this new delivery system could be employed as an efficient nutritional support in the management of tobacco withdrawal.

References 1. J. Daver, et al., Repères Pour la Pratique: Aide au Sevrage d’une Personne Souhaitant Arrêter de Fumer (2007). 2. L. Miclo, et al., “Characterization of a-Casozepine, a Tryptic Peptide from Bovine aS1-Casein with Benzodiazepine-Like Activity,” FASEB J. (express article 10.1096/fj.00-0685fje), published online 8 June 2001. 3. M. Messaoudi, et al., “Effect of a Tryptic Hydrolysate from Bovine Milk as1-Casein on Hemodynamic Responses in Healthy Human Volunteers Facing Successive Mental and Physical Stress Situations,” Eur. J. Nutr. 44(2), 128–132 (2004). 4. D. Lanoir, et al., “Long-Term Effects of a Bovine Milk Alpha-S1 Casein Hydrolysate on Healthy Low and High Stress Responders,” Stress, 5(Suppl.), 124 (2002). 5. J.H. Kim, et al., “Efficacy of as1-Casein Hydrolysate on Stress-Related Symptoms in Women,” Eur. J. Clin. Nutr. 61(4), 536–541 (2006). 6. C.M. Grilo, et al., “Stressful Life Events Predict Eating Disorder Relapse Following Remission: Six-Year Prospective Outcomes,” Int. J. Eat. Disord. doi:10.1002/eat.20909 (29 March 2011). 7. M. Tseng and C.Y. Fang, “Stress is Associated with Unfavorable Patterns of Dietary Intake Among Female Chinese Immigrants,” Ann. Behav. Med., Epub ahead of print (8 March 2011).

For more information Alain Baniel (a.baniel@ingredia.com), Research and Development Manager, and Harmony Villemin (h.villemin@ingredia.com), Product Manager/Public Relations Ingredia Nutritional 51–53 avenue Fernand Lobbedez BP 60946 F-62033 Arras, France Tel. +33 3 2124 6512 www.ingredia.com

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Superfruits The Power of Polyphenols Recent research reveals the potential benefits of dietary supplementation with the polyphenols that can be found in red, red/purple and blue fruits and berries. Although most are not essential for life, their benefit to well-being and health are endless and potentially lower the risk of cardiovascular disease, high blood pressure, diabetes and cancer.

ecent evidence demonstrates that plant polyphenols have numerous benefits, such as helping to improve endothelial function, inhibiting abnormal platelet aggregation, supporting healthy blood lipids, fighting inflammation, quenching free radicals, enhancing endogenous antioxidant enzymes and up-regulating both cyclic AMP (cAMP) and mitochondrial biogenesis.1 In 2005, the first International Conference on Polyphenols and Health strongly suggested that consuming more polyphenols can help to prevent degenerative diseases, especially in cardiovascular disorders and cancer.2 It is therefore not surprising that fruits and berries rich in polyphenols, and their extracts, are being marketed as “superfruits.” Phytonutrients, from phyto meaning “plant” in Greek, are certain organic compounds known to promote human health. One of the major classifications of phytochemicals in foods is polyphenols, which are found in the form of ellagic acid in fruits such as strawberries, blueberries and raspberries, and in the form of stilbenes in grape skin, peanuts and Japanese Knotweed. Traces have also been identified in purple, red/purple and blue fruits and berries, purple cabbage, beets, grape seed extract, tea, wine, cocoa, coffee, onion, apple skin and soybeans.

What the Experts are Saying Functional foods and drinks fortified with so-called superfruits are usually very high in polyphenols. And well they should be, considering their vast array of potential benefits. Extracts from blackcurrants, which are rich in anthocyanins, may reduce inflammation in the lungs and potentially offer benefits to the increasing number of

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asthmatics. Antioxidant-rich extracts of blueberries in a dose-dependent manner may also counter the detrimental effect of oxidative stress caused by excessive exercise.4 A water-soluble mixture that is naturally rich in citrus bioflavonoids, such as orange juice, was found to be capable of inhibiting increased capillary permeability and acting as an anti-inflammatory across a larger pH range of exudates than even cortisone.5 This may help to prevent the negative effects of the free radical and endotoxin cascade that follows a high-fat, high-carbohydrate meal.6 Berries such as bilberries, blackcurrants, cranberries and strawberries, which are rich in polyphenols, decreased the postprandial glycemic response of sucrose in healthy subjects, adding more evidence to their potential for lowering the risks of obesity, diabetes and cardiovascular disease.7 Data presented at the American Society for Nutrition at the Experimental Biology in 2010 showed that extracts from the chokeberry may prevent weight gain in prediabetics and affect genes linked to the development of fat tissue and related inflammatory pathways. Furthermore, the chokeberry-supplemented group was found to have lower blood glucose and reduced levels of plasma triglycerides, cholesterol and low-density lipoprotein cholesterol, which suggests the potential to lower the risk of

heart disease and diabetes. Other studies have shown that black chokeberry regulates immune function in patients with breast cancer, suppresses the growth of human colon cancer cells, allows less oxidative damage to red blood cells during vigorous exercise and lowers blood pressure (11 mmHg systolic and 7 mmHg diastolic).8–10 Another study presented that grape consumption lowered blood pressure, improved heart function and reduced other risk factors for heart disease and metabolic syndrome, such as reduced inflammatory indicators in the heart and blood, lower triglycerides and improved glucose tolerance. “The possible reasoning behind the lessening of metabolic syndrome is that the phytochemicals were active in protecting the heart cells from the damaging effects of metabolic syndrome,” said presenter Steven Bolling, MD, heart surgeon at the University of Michigan Cardiovascular Center and head of their Cardioprotection Research Laboratory. Resveratrol, naturally rich in grape skins, is a polyphenol that Harvard researchers discovered led to a 25% increase in lifespan in mice. Furthermore, studies from France showed that mice fed resveratrol did not gain weight when compared with controls that were given a high-fat and high-calorie diet. Beyond this, a number of other studies have demonstrated resveratrol to have

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health management

antioxidant, anticancer, anti-inflammatory and cardioprotective properties.11 Resveratrol, along with quercetin, also increases cAMP through mitochondrial biogenesis, which no doubt relates to their life extending and sports performance enhancing properties.12 The high polyphenol (procyanidin) content of apples is largely responsible for their ability to lower blood cholesterol, inhibit triglyceride absorption and abdominal fat accumulation, and enhance insulin sensitivity.13–16 In addition, apple polyphenols have the potential to reduce allergic conditions by blocking the release of histamine.17–22 Grape seed extract contains high levels of procyanidin dimers that have been shown to be potent inhibitors of aromatase, displaying potential usefulness in the prevention and treatment of hormone-dependent breast cancer.23 Polyphenol-rich pomegranate juice possesses antiatherosclerotic and antihypertensive properties, acting both as a powerful antioxidant and as an angiotensin converting enzyme inhibitor, lowering systolic blood pressure by 5%.24

polyphenols (anthocyanins in pomegranate) in a dose-dependent manner in both in vitro and ex vivo models.35 Indeed, in a very recent

Superfruit Synergy?

References

Wellberry is not an actual fruit. It is a unique patented combination of Indian Gooseberry, also known as amla fruit and a patent pending form of vegetable fatty acid form of vitamin C plus bioflavonoids, called PureWay-C. Amla has been shown to reduce the effect of ageing on renal dysfunction related to oxidative stress and significantly reduced systolic blood pressure. Amla may therefore be useful for the prevention of age-related renal disease.25,26 Amla has also been shown to help protect smokers and act as a natural skincare ingredient.27,28 By itself, this new vegetable fatty acid form of vitamin C with bioflavonoids has been shown to possess the best absorption and retention rates of any commercial form of vitamin C.29,30 It is proven to be more rapidly absorbed and leads to higher serum vitamin C levels.31,32 However, when mixed together with amla fruit extract in an aqueous solution, the combination displayed greater antioxidant capacity than was predicted based on the sum of their individual antioxidant values.33

Polyphenols: The More the Merrier? Even polyphenols from different plants seem to work synergistically when consumed together, with benefits from the combination equalling more than the sum of the parts.34 For example, amla has been shown to increase the antioxidant power of other

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May/June 2011

study, concentrates of berry powder (bilberry, blackberry, blackcurrant, blueberry, cranberry, concord grape, elderberry, raspberry and red currant) plus a vegetable powder (acerola cherry, apple, beet, broccoli, cabbage, carrot, cranberry, kale, orange, peach, papaya, parsley, pineapple, spinach and tomato) have been shown to reduce inflammatory biomarkers by between 16 and 35%. The authors concluded: “The close relationship between chronic inflammation and poor human health suggests that such a juice concentrate is a beneficial addition to the habitual diet in support of human health.”36 Nature’s bounty of polyphenols appears to combat free radical damage and inflammation, thereby potentially lowering the risk of cardiovascular disease, high blood pressure, diabetes, cancer and all-toocommon allergic conditions. Furthermore, it appears that taken together, the sum

of potential protections and benefits is greater than the individual food, extract or supplement. The take home message is nothing new. Almost everyone should consume 7–9 daily servings or more of fruits and vegetables of all colours. This includes the polyphenols that are generally richest in the red/purple berries, pomegranates and blueberries. For those desiring the benefits of polyphenols but, for whatever reason, must avoid them or find it difficult to consume them daily, current science appears to support supplementation with fruit and vegetable juice powders that are rich in polyphenols as the next best thing.

For more information Dr John H. Maher Director Education and Research BioPharma Scientific, Inc. 9010 Kenamar Drive, Suite 101 San Diego, CA 92121, USA. Tel. +1 858 622 9493 jmaher@biopharmasci.com www.superfoodsolution.com

1. L. Barclay, LE Magazine (Febuary 2008), www.lef.org/magazine. 2. A. Scalbert, I.T. Johnson and M. Saltmarsh, Am. J. Clin. Nutr. 81(1 Suppl), 215S–217S (2005). 3. S.M. Hurst, et al., Molecular Nutrition and Food Research, published online ahead of print, doi:10.1002/mnfr.200900297. 4. R.D. Hurst, et al., Molecular Nutrition & Food Research 54(3), 353–363 (2005). 5. V. Menkin, Am. J. Physiol. 196, 1205–1210 (1959). 6. H. Ghanim, et al., Am. J. Clin. Nutr. 91(4), 940–949 (2010). 7. C. Törrönena, et al., British Journal of Nutrition 103, 1094–1097 (2010). 8. S.V. Valcheva-Kuzmanova and A. Belcheva, Folia Med. (Plovdiv) 48(2), 11–17 (2006). 9. L. Pilaczynska-Szczesniak, et al., Int. J. Sport Nutr. Exerc. Metab. 15(1), 48–58 (2005). 10. M. Naruszewicz, et al., Atherosclerosis 194(2), 179–184 (2007). 11. J.M. Smoliga, J. Bost and J.C. Maroon, Antiaging Therapeutics, 11(46), 361–369 (2009). 12. W. Chowanadisai, et al., The Journal of Biological Chemistry 285, 142–152 (2010). 13. Y. Akazome, et al., J. Oleo. Sci. 54,143 (2005). 14. H. Sugiyama, J. Agric. Food Chem. 55(11), 4604–4609 (2007). 15. Y. Ogino, et al., Lipids 42(2), 151–161 (2007). 16. Y. Ohta, et al., J. Oleo. Sci. 55(6), 305–314 (2006). 17. Y. Ohta, et al., J. Oleo. Sci. 54(6), 287–294 (2007). 18. K. Osada, et al., Lipids 41(2), 133–139 (2006). 19. Y. Nagasako-Akazome, et al., J. Oleo. Sci. 56(8), 417–428 (2007). 20. T. Kanda, et al., Biosci. Biotechnol. Biochem. 62(7), 1284–1289 (1998). 21. T. Tokura, et al., Biosci. Biotechnol. Biochem. 69(10), 1974–1977 (2005). 22. T. Enomoto, et al., J. Investig. Allergol. Clin. Immunol. 16(5), 283–289 (2006). 23. I. Kijima, et al., Cancer Res. 66(11), 5960–5967 (2006). 24. M. Aviram and L. Dornfeld, Atherosclerosis 158(1), 195–198 (2001). 25 T. Yokozawa, et al., J. Agric. Food Chem. 55(19), 7744–7752 (2007). 26. Ibidem. 27. G. Block, et al., J. Am. College Nutr. 23, 141–147 (2004). 28. R. Chaudhuri, Skin Pharmacol. Appl. Skin Physiol. 15, 374–380 (2002). 29. D. Pancorbo, et al., Med. Sci. Monit. 14(11), 547–551 (2008). 30. B. Weeks and P. Perez, Med. Sci. Monit. 13(3), 51–58 (2007). 31. B. Weeks and P. Perez, Med. Sci. Monit. 13(10), 205–210 (2007). 32. D. Pancorbo, C. Vazquez and M.A. Fletcher, Med. Sci. Monit. 14(11), 547–551 (2008). 33. Nutritional Products Insider, “NutraGenesis Introduces Wellberry Branded Superfruit Ingredient (4 August 2008), www.npicenter.com/anm/templates/newsATemp.aspx?articleid=21789&zoneid=8. 34. Ibidem. 35. Ibidem. 36. Y. Jin, et al., Molecular Nutrition and Food Research, published online ahead of print, doi: 10.1002/mnfr.200900579.

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Rapid Analytical Testing of Nutraceutical Compounds With regulatory requirements for the production and quality assurance of nutraceutical compounds becoming increasingly stringent, it is essential for nutraceutical manufacturers to incorporate analytical techniques that produce reliable and repeatable results. As the final step of the manufacturing process, analysis must be as streamlined as possible to prevent delaying distribution. Emerging technology is presenting the possibility of rapid analysis using high-pressure liquid chromatography without the concomitant requirements for ultra-high-pressure systems.

uring the last decade, increasingly strict regulation of the production and marketing of nutraceuticals and dietary products has emphasized on the importance of analytical testing in the manufacture of such products. Nutraceuticals are typically categorized as food products, avoiding the legal and regulatory approval that pharmaceutical compounds are subject to. However, this legal categorization may sometimes be blurred, with nutraceuticals occupying a middle ground between food and drugs, and the specific legislation differing between compounds or situations based on perceived risk.1 Although nutraceuticals do not constitute a specific food category under EU law, several legislative directives are applicable to health and dietary supplements, and the ongoing interpretation of Regulation (EC) No. 1924/2006 by the European Food Safety Authority

(EFSA) emphasizes the increased scrutiny of the nutraceutical market.2–5 EFSA expects to complete the evaluation of general function health claims as specified by the European Commission by the end of June 2011. Since 2007, the US Food and Drug Administration (FDA) has required compliance with mandatory Good Manufacturing Practices (cGMPs), which was introduced in stages dependent on the manufacturer size and is now in force for all dietary supplement manufacturers.6 The GMPs include the evaluation of the identity, purity, strength and composition of the products, as well as controls to minimize any issues of product contamination. These increasingly stringent regulatory controls serve to emphasize the importance of reliable analytical testing of manufactured products — adherence to cGMPs is not only a matter of legal requirement but ensures consistent quality and

content of manufactured products. The detection and quantification of target compounds play a critical role in nutraceutical quality assurance and control; such analytical testing not only measures the levels of nutritional and non-nutritive additives but also acts as a safety measure to detect any impurities or contaminants that could have been introduced during the manufacturing process. As an integral part of the manufacturing process, analytical testing will be built into the production and distribution timeline … and effective communication with the testing laboratory will ensure this process runs smoothly (for a more detailed discussion on these considerations, see the previous NBT article The Bottleneck of Analytical Testing [Sept/Oct 2009]). Technological and protocol advances mean that analytical testing is becoming cheaper and faster. Here, we discuss the implications of new technology that allows accurate liquid chromatography testing in a short timeframe without the need for highpressure components and the associated cost implications.

High Performance Liquid Chromatography

Figure 1: Compounds of interest were dissolved in water at 1 mg/mL. Equal aliquots were combined to produce a mixed sample.

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Analytical laboratories typically rely on high performance liquid chromatography (HPLC) systems for the separation and quantification of target compounds. These systems assess the time taken for analytes to move through a column that’s densely packed with particles to provide a measurement of the characteristics of a particular sample. The performance of these analyses, including the separation efficiency, degree of resolution and analysis time, is dependent on the column particle size (affecting the physical and chemical interactions of the analyte moving through the column) and the column length — decreasing the particle size and/or increasing the column length increases the sample resolution.7 However, smaller particle increases size the backpressure and so present a technical constraint on the system.

technology

2A: Agilent ZORBAX Eclipse Plus C18, 4.6 mm × 250 mm, 5 µm column.

2B: Agilent ZORBAX Eclipse Plus C18, 3.0 mm × 100 mm, 3.5 µm column.

2C: Agilent ZORBAX Eclipse Plus C18, 3.0 mm × 100 mm, 1.8 µm column.

particles to increase analytical performance. HPLC columns packed with sub-2 µm particles provide superior resolution and decreased analysis time compared with traditional 5 µm particles. However, as described above, this improved performance comes at the cost of an increase in system backpressure, requiring high-pressure enabled components and columns. Now, a new technology focusing on the permeability characteristics of the particles, rather than the particle size, may offer an alternative answer for laboratories that wish to translate their current methods to a sub-2 µm method but cannot afford a high pressure LC. Columns packed with superficially porous particles such as the Agilent Poroshell 120 column offer resolution and speed similar to columns packed with 1.8 µm particles, without generating high backpressure. The partially porous particles used in the Agilent Poroshell 120 column provide a high efficiency, of a similar level to that offered by sub-2 µm totally porous particles. This increased efficiency results from a short mass transfer distance and substantially narrower particle size distribution. With both systems providing similar efficiency, the real benefit of using superficially porous particles is seen in the pressure reduction, with the larger 2.7 µm Agilent Poroshell 120 particles generating very low backpressure — about 40–60% of the backpressure generated by sub-2 µm totally porous particles. This allows the columns to run faster flow rates without exceeding HPLC pressures or requiring supplementary equipment to cope with higher pressures. In addition, Agilent Poroshell 120 columns with 2 µm frits are more forgiving of dirty samples than 1.8 µm columns, providing a more seamless method transfer from traditional 5 µm columns. 9–11

Partially Porous Particles in Practice 2D: Agilent Poroshell 120 EC-C18, 3.0 mm × 100 mm, 2.7 µm superficially porous column. Figure 2: Separation of 11 food and beverage additives on the four study columns using an ammonium acetate/acetonitrile gradient (Mobile phase: A = 20 mM ammonium acetate, pH 4.80; B = acetonitrile; temperature = 30 °C).

Most conventional HPLC systems operate at approximately 400 bar with a particle size of 5 µm.8 However, the introduction of ultra-high performance liquid chromatography (U-HPLC) means that these parameters are constantly being challenged. These additional technical requirements, howerevere do not come without financial and time implications most laboratories

must compromise between maximizing the resolution of the analytical results and ensuring a rapid analysis at a realistic cost.

A Novel HPLC Column Technology The introduction of U-HPLC thas triggered a desire to move towards the use of chromatography columns with sub-2 µm

A recent study has investigated the feasibility of introducing such systems in laboratories currently using conventional HPLC methods, by demonstrating the transfer of established methods using longer columns packed with 5 µm particles to a UHPLC-like method using superficially porous particles packed in shorter columns, while keeping the system backpressure below 400 bar. In the study, the Agilent Poroshell 120 column was compared with three different columns using totally porous particles of different sizes. The comparative columns were all used with the same liquid chromatography system — the Agilent 1200 Rapid Resolution LC (RRLC) system. The benefits of using the

May/June 2011 www.nutraceuticalmag.com

technology

Figure 3: An overlay of the original Agilent Eclipse Plus 5 µm method and new Agilent Poroshell 120 method.

Figure 4: Overlay showing the effect on chromatographic quality with increased flow rate.

Agilent Poroshell 120 column, as described in more detail below, included a decrease in sample and mobile phase consumption, significant time savings and the selectivity and efficiency of a sub2 µm analysis on virtually any HPLC system.8 A group of 11 non-nutritive food and beverage additives was used to demonstrate this method translation. The compounds included preservatives, artificial sweeteners, an energy supplement and a flavouring agent. These additives are commonly used in food and supplement manufacturing, and although the compounds are not harmful in appropriate amounts, they can cause sensitization and allergic reactions after excessive exposure.12 Therefore, as with any additive, detection and quantification of these additive compounds is extremely important. The compounds of interest are shown in Figure 1, with their respective structure, pKa value (logarithmic function of disassociation constant) and additive function. Figure 2 shows the separation of 11 food and beverage additives on each of the study columns. The flow rate and times differ for each column. The initial reaction, using a traditional

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Agilent ZORBAX Eclipse Plus C18, 4.6 mm x 250 mm, 5 µm column, took 13.1 minutes to complete the analysis. The second separation, using the ZORBAX Eclipse Plus C18, 3.0 mm x 100 mm, 3.5 µm achieved a significantly shorter analysis time of 3.5 minutes, and the flow rate for this analysis was adjusted to compensate for the smaller internal diameter and for the smaller particle size. However, the 3.5 µm column did not resolve two peak pairs: benzoic acid/aspartame and dehydroacetic acid/methylparaben. The Agilent ZORBAX Eclipse Plus C18, 3.0 mm x 100 mm, 1.8 µm column (with flow rate for the 1.8 µm column adjusted to optimize the smaller sub-2 µm particles) managed to resolve all compounds well in just over 2.5 minutes. This faster analysis can enhance laboratory productivity and lower the mobile phase and solvent consumption. A smaller sample volume is required for the smaller 3.0 mm x 100 mm column, thus yielding sample preservation. The benefits of this sub-2 µm separation, however, are at the cost of higher backpressure (483 bar), resulting in the need for a high pressure LC system. Finally, the

last chromatogram in Figure 2 shows the same separation on a superficially porous Agilent Poroshell 120 EC-C18, 3.0 mm x 100 mm, 2.7 µm with the same shortened analysis time as the 1.8 µm column. This separation has the added benefit of lower backpressure (356 bar). The more than 100 bar difference in pressure is very significant, because it determines whether a high pressure HPLC system is needed or if a traditional system (400 bar maximum) is sufficient for this analysis. The chromatograms shown in Figure 2 are displayed on x-axes of different scales, reflecting the difference in resolution times. When the results for the original 5 µm method are compared with the new Agilent Poroshell 120 method on the same scale, the differences in analytical time and resolution become apparent (Figure 3). Analysis time is reduced from 13.1 to 2.6 min, with the post-run time reduced from 7 to 1.8 min. Solvent and mobile phase consumption are reduced by more than 80%. Resolution of the critical pair (dehydroacetic acid and methylparaben) improved from 1.79 to 3.01 on the Agilent Poroshell 120 method, compared with the longer 5 µm Agilent ZORBAX Eclipse Plus method. Note, in Figure 3, that the last peak on Agilent Poroshell 120 elutes at approximately the same time as the first peak on the 5 µm Agilent ZORBAX Eclipse Plus. Having demonstrated the efficiency of the porous particle technology at conventional pressures, it is also interesting to consider the performance in other conditions, when pressure is not a constraint on analytical parameters. When high throughput is important and HPLC system limits allow, the flow rate can be increased with little loss in chromatographic quality, as shown in Figure 4. The flow rate on the Agilent Poroshell 120, 3.0 mm x 100 mm column can be increased from 0.851 to 1.489 mL/min to further reduce run time by 40% in under 600 bar. This achieves little loss in resolution of the critical pair and has minimal effects on conditional peak capacity (nc).13 The result is a baseline separation of 11 compounds in under 600 bar backpressure with an analysis time of 1.5 minutes.

Conclusion HPLC columns packed with superficially porous particles offer many advantages compared with columns packed with conventional, fully porous particles. The superficially porous 2.7 µm Agilent Poroshell 120 EC-C18 column offers similar efficiency and selectivity to the 1.8 µm Agilent ZORBAX Eclipse Plus C18 column, without the high back pressure. Although larger 5 µm particles packed in longer columns can yield similar

technology

efficiency without high backpressure, they result in a significantly longer analysis time. Owing to the similar selectivity between Poroshell 120 EC-C18 and Eclipse Plus C18, methods can easily be transferred from older Eclipse Plus C18 columns to new Poroshell 120 EC-C18 columns. This achieves lower backpressure for older 400 bar HPLC systems, shorter run times and solvent savings. To ensure the safety and quality of nutraceutical products, it is critical for manufacturers to be able to reliably determine levels of components in the manufactured product. Recent technological advances mean that analysis is increasing in accuracy and reliability, and can be achieved in shorter timescales without increasing the system pressure over conventional levels — streamlining the compound analysis and quality assurance stages.

For more information Anne E. Mack and William J. Long Agilent Technologies, Inc. 2850 Centerville Road Wilmington, Delaware 19808, USA. www.agilent.com A5 quer-4c-D-F-E:Layout 1

07.09.2010

References 1. O.P. Gulati and P.B. Ottaway, “Legislation Relating to Nutraceuticals in the European Union with a Particular Focus on Botanical-Sourced Products,” Toxicology 221, 75–87 (2006). 2. P. Coppens, M.F. da Silva and S. Pettman, “European Regulations on Nutraceuticals, Dietary Supplements and Functional Foods: A Framework Based on Safety,” Toxicology 221, 59–74 (2006). 3. Regulation (EC) No. 1924/2006 of the European Parliament and of the Council of 20 December 2006 on Nutrition and Health Claims Made on Foods (OJ L 404, 30.12.2006, p 9), http://eur-lex. europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:3 2006R1924R(01):EN:NOT (accessed March 2011). 4. EFSA, “Modus Operandi for Article 13(3) Health Claims of Regulation (EC) No. 1924/2006,” www.efsa.europa.eu/en/ndaclaims/ndaclaims13. htm (accessed March 2011). 5. EFSA, Database of Health Claims Submitted to EFSA for Evaluation,” www.efsa.europa. eu/en/ndaclaims/ndaclaims13.htm (accessed March 2011). 6. US FDA, “Current Good Manufacturing Practices (CGMPs) Dietary Supplements Final Rule, 2007,” www.fda.gov/Food/DietarySupplements/ GuidanceComplianceRegulatoryInformation/ RegulationsLaws/ucm079496.htm (accessed March 2011). 15:23 Uhr Seite 3

7. J. Kofman, et al., “Ultra-High Performance Liquid Chromatography: Hope or Hype? American Pharmaceutical Review, March/April 2006, http:// americanpharmaceuticalreview.com/ViewArticle. aspx?ContentID=351 (accessed March 2011). 8. A.E. Mack and W.J. Long, “Fast, Low Pressure Analysis of Food and Beverage Additives Using a Superficially Porous Agilent Poroshell 120 ECC18 Column,” Agilent Technologies publication 5990-6082EN (2010). 9. W.J. Long and A.E. Mack, “Fast Analysis of Sulfa Drugs using the Agilent 1100 Series LC with Agilent Poroshell 120 EC-C18 Columns,” Agilent Technologies publication 5990-5572EN (2010). 10. A. Gratzfeld-Hüsgen and E. Naegele, “Maximizing Efficiency Using Agilent Poroshell 120 Columns,” Agilent Technologies publication 5990-5602EN (2010). 11. V.R. Meyer, Practical High Performance Liquid Chromatography, 4th Edn (John Wiley & Sons, Inc., Hoboken, New Jersey, USA, 2004) p 34. 12. A. Brooks and W.J. Long, “Selective Analysis of Non-Nutritive Food Additives Using Agilent ZORBAX Eclipse Plus 18, Eclipse Plus PhenylHexyl, Eclipse XDB-Phenyl and Stable Bond SB-Phenyl Columns,” Agilent Technologies publication 5989-9951EN (2008). 13. J. Henderson and J. Berry, “UHPLC of Polyphenols in Red Wine,” Agilent Technologies publication 5990-5659EN (2010).

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We’re taking a (super)critical look at extract quality

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NutrEvent The Future of

Nutrition and Health

Where innovation and regulation meet nutrition.

urasanté, the life science economic development agency of the Lille-Nord Pas de Calais Region, the Nutrition, Health and Longevity Cluster, Lille’s network of companies and research institutes in the healthcare and agro-food fields and Lille Grand Palais, the leading events organizer in Lille, are delighted to announce the second edition of NutrEvent, taking place in Lille, France, on 15–16June. With the growth of personalized nutrition, the development of open innovation, the need for collaborative projects and the tumultuous debates surrounding health claim regulation, it comes as no surprise that the nutrition and health sector is currently experiencing one of its most complex periods of development and growth. And a time such as this requires evolutions — and revolutions — in the way that partnerships and business strategies are conceived and managed. Both academia and industry from the nutrition and health sector are showing a growing interest in collaborative projects, whereas public-private collaboration is increasingly being stimulated as

a result of national and international funding schemes. NutrEvent sits in the number one position as an event entirely dedicated to innovation and research in the field of nutrition and health. Its aim, to bring together the stakeholders of this sector to promote new ways of getting academia and industry to collaborate, has already proved its fruitfulness during its first edition in 2009, leading to many successful partnerships. The 2011 edition already promises to be even more fruitful, thanks to the quality and diversity of its 1500 international delegates. To reach this ambitious goal and to continue to help to invent the future of nutrition and health, NutrEvent will offer a number complementary activities: a partnering event based on prescreened one-to-one meetings; a conference programme, validated by a steering committee composed of 21 renowned European experts; an international exhibition to promote research and projects; and a career fair — a unique opportunity for companies to find new talent and for candidates to boost their careers.

“An ideal forum to network with other academics and industry representatives to identify possible research partners for future collaboration.” Kieran Tuohy, Group Leader, IASMA

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From biological silos to non-dairy probiotics

In 1983, Yves Delatte managed to implement the first fully successful biological silo in Seinäjoki (Finland), which was followed by probiotics directed at livestock between 1983-1988. These probiotics contained living lactic acid bacteria and carbohydrate and sugar sources, which activate the mixture prior to absorption in the intestines. In fact, the formula was quite simply and logically the same as previously used in silos. The same man was behind the market’s first probiotics, in Holland, France & Scandinavia and these products are still on the market. One of the products was chosen as the Finnish health food of the year in 1997. The background to these products is actually the technology that was developed 30 years ago! Now, Biolatte Oy has a new range of products which differs from such products which have been prepared with the old technology, which has too often been copied. We only make high quality and efficient products, instead of mixtures.

Our products:

Non-dairy probiotics since 1980

carbohydrates are no longer used, as they also bring along moisture and fertilizer residues, which can be harmful to people suffering from allergies. inulin is no longer used. Inulin is a residue of the sugar industry, and it has not been proven to possess any “in vivo” value. Instead, inulin strengthens the growth of bacteria, including pathogenic bacteria, and such risks should not be taken in the manufacture of probiotics. Biolatte Oy does not use bacteria from the dairy industry in its products, the health influences of which have already been seen in yoghurt. We use only human specific bacterial strains, which, due to the immunological properties cling to the intestinal epithelium, or to the mucosa. Biolatte Oy does not manufacture the products in tablet form or in blister packaging, as the hot temperature and pressure used in the process kills most of the bacterial strains.

From this perspective, we have developed the Biolatte product range which seems to be superior to all other products on the market in regard to its quality, stability and efficiency. Biolatte products have already been on the market for years and have received a great deal of good and satisfactory feedback.

See us at Stand 2222 and on www.biolatte.com

May/June 2011 www.nutraceuticalmag.com

event preview

As General Commissioner, I am very glad to announce — on behalf of the co-organizers of the event, Eurasanté, Lille Grand Palais, the Nutrition, Health and Longevity Cluster and its steering committee — the second edition of NutrEvent (15–16June in Lille, France). Etienne Vervaecke Finally, the second edition of NutrEvent introduces a new initiative, the NutriAwards, to reward the best innovative projects from academics, emerging companies and SMEs in the field of nutrition and health. NutrEvent 2011 benefits from the support of two partners of choice: a prestigious steering committee comprising 20 renowned European experts who represent industry, academia, clusters, the media and various associations, and the EDB Group, who will provide its famous partneringOne software to manage the show’s partnering activity. “We are

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excited to collaborate with the EBD Group,” said Etienne Vervaecke. “Their proven ability to facilitate partnering on a large scale brings immediate credibility to NutriPartnering, NutrEvent’s business partnering convention.” As Nico Van Belzen, Executive Director of ILSI Europe, sums up: “NutrEvent provides an important forum to discuss — in an integrated way — both science, innovation and marketing. I think the 2011 edition will serve to establish a tradition of NutrEvent meetings.” To reach this goal, NutrEvent 2011 will combine several activities: at the core of the event, NutriPartnering, the NutrEvent business partnering convention, will welcome more than 500 international participants to 2000 prescheduled one-to-one meetings; NutriConference, NutrEvent’s conference programme will comprise 15 workshops featuring 60 international speakers; NutrExpo, an international exhibition with more than 100 stands to promote research and project; NutriCareer, a career fair as a unique opportunity for companies to find new talent and candidates for the jobs they offer.

NutriExpo Come and meet the exhibitors! NutrExpo is the leading European trade show dedicated to innovation in nutrition and health; it represents a major opportunity to meet most of the sector’s decision makers, including R&D directors, business developers, marketing managers, clusters representatives, regulatory affairs specialists and service providers. NutrExpo will welcome 100 exhibitors to its 2000 m2 dedicated exhibition area. Some of the participants already registered include Analyze & Realize, Antwerp University Hospital, Biofortis, Cargill, CIAA, DSM Nutritional Products, EUFIC, European Commission Flander’s Food, Food Nutrition Delta, Freshforward, General Mills, Ghent University, Greentech, Groupe Casino, GSK, IASMA, ILSI Europe, Indena, Ingredia, Institut Pasteur de Lille, Keyrus Biopharma, Leatherhead Food Research, Lesaffre Human Care, Marigot Ltd, Naturalpha, Naturex, Nizo Food Research, Ocean Nutrition Canada, Roquette, Tate & Lyle, TIFN, TNO Quality of Life, Unilever, Valorial, Wagralim and so many more.

NutriConference Come and Learn the Innovation Process! Entitled “Innovate from A to Z,” the conference programme offers an innovative way

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to show both the stepwise approach to product development as well as the regulatory framework and marketing strategies needed to make a product successful in the marketplace. The “Breakthrough and Discoveries from the Bench” track is dedicated to the first steps of the innovation process, those that are science-based and aim to promote optimal product innovation and public health outcomes. The two topics in this track, “Gut Health and the Immune System” and “Cardiovascular Diseases and Weight management,” were chosen because both have a tremendous impact on consumer well-being and public health. For both areas, health depends on eating a balanced diet and can be further improved by choosing foods that convey specific benefits. NutrEvent 2011 expects 50% of its participants to be foreign and 80% of its speakers to be international. “We have to be aware that it is useless to discuss regional or even national progress. So a conference in a North-Western European setting is just what we need — to join forces and build the networks that will have a major impact,” said Kees De Gooijer, General Director of Food Nutrition Delta. Innovation management is about the development and exploitation of ideas into commercially successful products. Whereas track A will takes a pure and scientifically focused look at the entire product development process, track B, entitled “Market trends and Regulatory Framework,” will illuminate innovation from a commercial point of view. Insight into consumer perception and preferences is extremely important to assess market size, choose the right communication strategies and tools, and assess business opportunities — and threats. For functional foods, one of the most important threats is regulatory affairs, such as health claims regulation. “I like the idea of following the R&D innovation pipeline from ingredient screening to product applications. Also, the parallel session on regulations and marketing is a nice fit,” said Douwina Bosscher, Cargill, Nutrition and Health Adviser.

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NutriPartnering Come and meet your future partners! Thanks to the EBD Group’s online platform, NutriPartnering will enable its participants to target their future R&D partners amongst the 1500 attendees. This networking tool will allow them to send requests and manage their schedule a few weeks before the event and thus enable the organization of 2000 prescheduled meetings during the 2 days of NutrEvent.

NutriCareer Come and meet new talent! The success of any project depends on finding the right partners, but also relies on finding and working with the right people within those companies. To help you with your searches, NutriCareer offers its participants the opportunity to meet their future employee and/or recruiter, thanks to • a conference on the emergence of new jobs in the field of nutrition and health, linked to the evolution of the market and open innovation • job dating: meeting with post-graduate students/recent alumni and HR directors from various profiles (companies, universities and research institutes, laboratories, CROs, public organizations, etc.).

NutriAwards The second edition of NutrEvent sees the introduction of a new initiative, the NutriAwards, which will reward the most innovative projects in the field of nutrition and health. The contest will allow all NutrEvent participants to compete for one of three prizes in the following categories: best project of company creation in nutrition and health, most innovative SME in nutrition and health and best nutrition and health poster.

For more information Etienne Vervaecke General Commissioner of NutrEvent 2011 and General Director of Eurasanté nutrevent.com

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The world’s leading nutraceuticals trade show • 8500 attendees • 1000s of new products & innovations • 500 exhibiting companies • 250 senior industry delegates • 30 free seminar sessions • 1 must-attend event

10 - 12 May 2011 | GENEVA PALEXPO | Switzerland

www.vitafoods.eu.com/nbt Organised by IIR

Co-located with

Finished Products Expo

Portfolio includes

May/June 2011 www.nutraceuticalmag.com Join us on

events

calendar

A round-up of events, trade shows and conferences in the global nutraceutical and functional foods sector during the coming months 2–4 May

25–27 May

SupplySide East Where Innovation Begins Secaucus, New Jersey, USA Contact Virgo Publishing, USA T. +1 480 990 1101 F. +1 480 990 0819 E. twillis@vpico.com W. www.supplysideshow.com

Mushroom Days 2011 Brabanthallen, ’s Hertogenbosch, the Netherlands Contact Stichting Champignondagen, the Netherlands T. +31 651 157 897 F. +31 183 769 049 E. info@champignondagen.nl W. www.champignondagen.nl

10–12 May

26–27 May

Vitafoods Europe The Global Nutraceutical Event Geneva, Switzerland Contact IIR Exhibitions Ltd, UK T. +44 207 017 7027 F. +44 207 017 7818 E. vitafoods@iirx.co.uk W. www.vitafoods.eu.com

Second Sports and Performance Nutrition Conference Amsterdam, the Netherlands Contact Bridge2Food, the Netherlands T. +31 30 225 2060 F. +31 84 832 7225 E. info@bridge2food.com W. www.bridge2food.com

11 May The Nutraceutical Business & Technology Awards A Celebration of Food Innovation Geneva, Switzerland Contact Via Media UK Ltd, UK T. +44 1372 364 122 F. +44 1372 364 121 E. miranda.docherty@via-medialtd.com W. www.nbtawards.com

Europe’s leading dietary supplements event

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June l 15 l 16 2011 Lille l France

Where innovation and regulation meet nutrition

the future nutrition & health

Come and invent of

✔ Partnering ✔ Conferences ✔ Exhibition ✔ Career Fair

nutrevent.com

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products

Supply Source New products, solutions, ingredients and innovations from the market-leading suppliers and manufacturers in the functional food and nutraceutical sector. New Products in the Pipeline

Reformulation Solutions

Martek Biosciences is expanding its omega-3 offering with two new products. The company has produced an emulsion form of its vegetarian life’sDHA, which will make it easier for manufacturers to create fortified beverages with DHA omega-3. The emulsion is designed for acidic and neutral beverages such as juices, smoothies and juice drinks. It remains liquid in frozen storage, meaning it can be used directly. Plus, an algae-based combination of DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) omega-3s has been developed and will soon be commercialized. The DHA/EPA blend is pure, safe, vegetarian and sustainable, offering an effective alternative to fish oil. The news comes after a recent boost for the omega-3 market, following a number of positive opinions from EFSA relating to health claims for DHA omega-3. The EFSA panel concluded that a cause and effect relationship was established between the consumption of DHA and the maintenance of normal (fasting) blood concentrations of triglycerides for heart health, the maintenance of normal brain function and the maintenance of normal vision. Cassie France-Kelly, Director, Corporate Communications, commented: “These recent EFSA opinions are a great first step towards achieving health claims in Europe. We’ve always been confident about the science behind DHA omega-3 and getting past the first stage is testament to the quality of the research. This regulatory news together with our NPD pipeline means it’s a very exciting time for Martek and our customers. Our EPA and DHA blend in particular is a huge breakthrough. Although we still believe DHA is the most important omega-3, for those consumers who are interested in the benefits associated with EPA, we now have a pure, fish-free option.” Martek Biosciences Corporation (www.martek.com) T. +1 410 740 0081 E. foodinfo@martek.com

Rousselot offers its “Rousselot Gelatine” range for the reformulation of healthier foods. Less fat, less sugar and fewer calories: for several years, the food industry has been striving to respond to consumer demand for healthier and more appealing foods. A multifunctional ingredient, Rousselot Gelatine can efficiently help manufacturers to design processed and indulgent foods that are reduced in fat, sugar and calories. The replacement of fats with a less caloric protein that’s able to bind 10 times its own weight of water can be done with gelatin. In addition, gelatin’s viscosity above melting point creates a smooth consistency and a perfect fat-like mouthfeel. Rousselot Gelatine also makes it easier to replace sugar with sweeteners, as it provides the finished product with a desirable texture. And, being a pure protein, Rousselot Gelatine can help to increase the protein content of processed foods, thus providing long-lasting satiety. Finally, as gelatin is a clean-label ingredient with no E number, implementation is easy. Rousselot (www.rousselot.com) T. +33 1 4667 8727 E. caroline.brochard-garnier@rousselot.com

Healthier Baking with CAL-RISE Innophos, a world leader in specialty phosphates, manufactures CAL-RISE — a sodium-free, high-in-calcium leavening agent for use in baked goods. This latest proprietary innovation represents an industry-first solution that enables food manufacturers to develop cost-effective, reduced sodium products that deliver quality taste, texture and appearance. The strong link between excessive sodium intake, predominately from salt, and health issues such as hypertension and cardiovascular disease has led governments and regulatory bodies to introduce industry wide salt/sodium reduction initiatives. In baked goods such as cakes, muffins and tortillas, up to a third of the overall sodium content can be derived from the leavening agent. CAL-RISE, however, is a sodium-free alternative that permits a 20–35% reduction in sodium in many baked goods. Furthermore, its functional benefits in terms of taste neutrality, texture and speed of reaction offer a unique solution to other low-sodium/sodium-free leavening agents on the market. “There is significant pressure on the food industry to cut sodium content,” comments Joseph W. Golowski, Vice President, Specialty Phosphates for Innophos. “Our challenge was to provide our customers in the baked goods industry with a cost-effective solution that does not compromise their products’ sensory attributes such as flavour, taste and texture. For this reason we are excited to offer the industry CAL-RISE, a sodium-free leavening agent that enables manufacturers to dramatically reduce sodium content. There is currently no other leavening agent on the market that delivers the same combination of sodium-reduction benefits and functional performance in such an easy-to-use and cost-effective format.” Innophos (www.innophos.com) T. +1 609 366 1235 E. john.brodie@innophos.com

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China: Driving Global Growth in the Health Food Market I Did you know that China is one of the fastest growing health food markets in the world?

n fact, China is now recognized as being a key player in the global health food industry. The US Department of Commerce reports that “with rapid economic growth and the continued improvement of peoples’ livelihoods, the demand for health food from China’s 1.3 billion people has expanded tremendously during the last 20 years.” The Nutrition Business Journal has also published a report identifying China as the country set to offer the greatest opportunities for the nutrition industry in the next 5 years, closely followed by the United

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States. Retail sales of health food in China were estimated to be $13.7 billion in 2009, surpassing Japan’s $12.9 billion and revealing China as being the second biggest health food market in the world after the US. The category of “health foods” incorporates functional foods, dietary supplements and foods claiming a dietary component that provides preventive health benefits beyond basic nutrition. As it stands, the level to which China’s population accepts and consumes health foods is far

below that of many developed nations; a 2010 research report of its health food market estimated consumer spending to be 0.07% of gross expenditure, in comparison with the 2% expenditure seen in Western nations. Factors such as high health food costs, a lack of confidence in native brands and low family incomes have hindered the growth of the nutrition industry in China. Nevertheless, the movement of Chinese consumers from subsistence living to commanding ‘middle class’ incomes

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June 11-14, 2011 | New Orleans, LA

IFT Is “Jazzing” It Up In New Orleans! Join us for hot solutions and cool products Are you serious about the science, and the business, of food? Then join your food science and technology colleagues (and competitors) as they travel from around the world to attend the IFT Annual Meeting & Food Expo. You’ll see the newest products, including ingredients, equipment, and processing/packaging; discover the hottest trends and how to turn them into a competitve advantage for your organization; and learn about the latest advances in food science. Plus, you’ll make important connections with other food professionals. Learn more about this year’s event and the Short Courses below, at ift.org/IFT11. Registration opens March 1.

93%

The percentage of attendees who found the 2010 Annual Meeting & Food Expo of value

Have a Deeper Taste for Knowledge? Maximize your education value when you register for a Pre-Annual Meeting Short Course. Short Courses offer focused professional development and the ability to earn continuing education credits. Courses offered this year include: • Food Science for the Non-Food Scientist • Ingredient Applications for Product Innovation and Consumer Health • Labeling Requirements and Implications for Foods Marketed in the U.S. • Microencapsulation in Food Applications • Developing Effective Influencing Skills • Sensory Testing for Product Development and Claims Support • Managing Risks Associated with Food Ingredient Safety • New Oils, New Labels, New Opportunities • Evaluating the Safety of Gulf Seafood: Programs and Analytical Techniques in the Aftermath of the Deepwater Horizon Spill

May/June 2011 www.nutraceuticalmag.com

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will invariably lead to an increase in food expenditure and a corresponding rise in health food consumption. Historically, the Chinese have enjoyed a healthy diet, of which vegetables and rice constitute the main staples. These are supplemented by fruit and small quantities of animal protein used to flavour and season the dishes. Much of the Chinese population is lactose intolerant, so flavourings such as broths, sauces and marinades are preferred to heavy, rich cream sauces. In addition, the Chinese diet features soy products including tofu and soy sauce; protein drinks and nutritional bars that include soy protein isolates are thus an ideal way to meet the nutritional needs of the lactose intolerant population. China’s nutritional reliance on small amounts of animal proteins and higher quantities of soy proteins is healthy and environmentally responsible. As the country’s population grows, its food supply shrinks, water supplies become more limited and food production competes for land with housing and fuel crops. In the coming decades, as global agriculture faces the prospect of a changing climate and the challenge of feeding the world’s growing population, renewable plant protein is likely to become a means by which food is delivered to regions vulnerable to deficits. Nutritious and functional soy and canola protein isolates are important plant-based ingredients for China’s health food industry. They are able to meet the body’s needs, providing all the essential amino acids required for proper growth, muscle tissue synthesis and a host of other vital processes. The global nutritional supplements industry has seen explosive growth in the use of protein ingredients during the past 10 years. Protein bars (once consumed only by endurance athletes), protein-rich meal replacement products and dietary supplements have become worldwide supermarket staples. In addition to this, protein supplements are being increasingly and successfully promoted to the expanding market of geriatric consumers.

From Different Kingdoms Plant proteins are differentiated from animal-based proteins in terms of their affordability, impact on health and effect on the environment. Health advantages associated with the consumption of plant proteins include the positive impact they may have in the fight against heart disease. In 1999, the US Food and Drug Administration issued a claim concerning a key health benefit of soy protein, stating that “25 grams of soy protein

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Sarah Medina

It is also a major source of land and water degradation. Indeed, to produce animal protein, plant protein must first be fed to livestock; animals, however, are not efficient converters, pound for pound, of the proteins they consume.

Future Growth

a day, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.” Research studies have demonstrated the cholesterol-lowering properties of soy protein, which effects blood cholesterol by reducing levels of LDL or “bad” cholesterol. In turn, this may reduce the likelihood of heart disease. On the strength of such evidence, 11 countries have approved health claims for soy protein’s potential to lower blood cholesterol and the risk of coronary heart disease. Plantbased diets are also high in fibre and lower in fat; diets such as these have been shown in numerous studies to lower the rates of certain cancers, including those of the colon, breast and prostate. A diet of this kind is also believed to reduce the risk of diabetes. Chinese consumers are paying increasing attention to the functionality of health food products. A health food consumption survey issued by the Hong Kong Trade Development Council revealed that 77% of consumers rank “immune enhancement” as an important function, followed by “nutritional supplement” and “antifatigue,” which were ranked as equally important by 49% of consumers. Health issues surrounding biocontaminants such as E. coli, Asian bird flu and BSE, in addition to the growing use of antibiotics in animal production, have provoked consumer concerns regarding the safety of animal-based protein products. These concerns, in combination with trends in consumer awareness, benefit the sales of plant-based proteins. Alongside the potential health benefits, the production of plant-based proteins is viewed as more “environmentally economic” than that of animal-derived proteins. Few people realize, for example, that rearing livestock causes more greenhouse gas emissions than cars. According to a report published by the United Nations Food and Agriculture Organization, the global livestock sector generates more emissions as measured in CO2 equivalents — 18% — than transport.

The growing population, both in China and worldwide, requires affordable protein; forecasts estimate that we will be providing protein for about 9 billion people by 2050. Serving this population without adding undue stress to our environment will demand access to affordable plant proteins. Soy is a widely accepted and economical source of this, offering both nutritional value and recognized health benefits. Providing for a global population is the motivation behind the development of CLARISOY, a unique soy protein isolate product that is 100% soluble, transparent and very low in viscosity in acidic beverages. CLARISOY facilitates the production of transparent, protein fortified liquid products such as juices, soft drinks and sport drinks that are in the low pH range (as low as 2.5). In these highly acidic beverages, CLARISOY is also heat stable, allowing thermal processing (including hot fill) with no loss in clarity or change in viscosity. Previously, beverage formulators looking to incorporate soy protein into their products were limited by the cloudiness introduced by the protein ingredients. CLARISOY, however, offers all the benefits of soy protein incorporation with minimal impact on the properties of the beverage to which it is added. Whereas China’s current annual per capita consumption of health foods is far below most Western countries at approximately $10, experts believe that its health food industry will continue to grow annually at about 20–30% for the foreseeable future, reaching $65.9 billion by 2020. New entrants into the Chinese health food market in the coming years will drive food costs lower and the influx of internationally branded products will increase Chinese consumer confidence in the functionality and quality of the products they purchase. As a result, we can expect to see the level of health food consumption in China increase at a rapid rate, gaining ground on those seen in Western nations.

For more information Sarah Medina is a Research Associate at Burcon NutraScience Corporation (www.burcon.ca), a leader in the development of functional, renewable plant proteins (smedina@burcon.ca).

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BIOIBERICA is a Spanish company whose main business activity is to develop, manufacture and market branded active ingredients and finished products for the pharmaceutical and nutraceutical industry. Focusing on osteoarthritis and immunology, Bioiberica is a worldwide expert in sulphated glycosaminoglycan research and one of the leading suppliers of chondroitin sulphate, glucosamine and hyaluronic acid. Vertically integrated from API to finished product, the company maintains a leading position within the Spanish chondroprotective drug market, thanks to its specialist team of pharmaceutical sales reps and expert knowledge base. The company is also active in the nutraceutical market with a range of innovative and science-based finished products for joint health and immunological support.

Major Products Nutraceutical range of products: – Branded ingredients: Acti-Joint®, CSBio-Active® – Finished products: • Hyal-Joint® caps (supports joint mobility) • Tendoactive® (for tendon health and recovery) • Hialsorb® (Joint massage) • Immunactive® (immune support)

BIOIBERICA, SA Plaza Francesc Macià, 7 E - 08029 Barcelona - Spain • T. +34 93 490 49 08 • F. +34 93 490 97 11 • E. cmartinez@bioiberica.com • W. www.bioiberica.com • W. www.hyal-joint.com • W. www.csbioactive.com January/February www.nutraceuticalmag.com May/June 2011 2011 www.nutraceuticalmag.com

congress report

Lutein and its Benefits in Eye health: A Congress Experts gather to discuss new research that aims to ensure healthy vision is safeguarded in ageing populations.

ealthy vision: one of the most important factors that contribute to an individual’s quality of life and the reason behind the congress, Lutein and its Benefits in Eye Health, which took place in Munich, Germany, last month. Longevity induced eye diseases, such as age-related macular degeneration (AMD), the leading cause of irreversible blindness in developed countries, are on the increase as populations continue to age. Deposited in the macula and lens, lutein acts as ‘internal sunglasses’ and protects the eyes against light-induced oxidative damage. During the congress, leading experts presented the latest findings on this essential carotenoid and its most clinically researched brand, FloraGLO Lutein. Epidemiological evidence has established a link between the benefits of the carotenoids lutein and zeaxanthin and improved eye health: lutein absorbs blue light and acts as a filter that may prevent the photochemical damage caused by short-wavelength visible light. The consumption of lutein and zeaxanthin is proven to increase macular pigment optical density (MPOD) in human eyes, which, in turn, is associated with a decreased risk of AMD and improved visual function. FloraGLO, manufactured by Kemin Health, is intended for inclusion in food supplements or as an ingredient for use in food and beverages. Kemin joined forces with DSM Nutritional Products Europe Ltd (DSM), sponsors of the congress, under an exclusive strategic alliance to globally commercialize lutein products. Together, they were able to utilize the patented Actilease technology to formulate DSM lutein beadlets, which provide excellent stability and superior bioavailability.

Latest Scientific Research Prof. Paul Bernstein from the Moran Eye Center, University of Utah, presented the very latest scientific research on the biological significance of lutein. He identified selective, high-affinity binding proteins for lutein, zeaxanthin and their metabolites and provided insights into future research and the emerging possibility of non-invasive approaches. The proposed improvements in visual performance and comfort parameters associated with lutein and zeaxanthin supplementation were discussed by

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Prof. B Randall Hammond from the University of Georgia, who presented trial results confirming this theory. He reported on the significant relationship between levels of lutein and zeaxanthin and their effects on visual function, such as photostress recovery, glare disability and chromatic contrast sensitivity. An ongoing clinical study was described by Mina Chung, PhD, from the Flaum Eye Institute, University of Rochester, investigating the extent to which lutein assists in reducing the progression and risk of AMD. The trial will evaluate the effect of treatment with lutein and zeaxanthin — alone or in combination with omega-3 fatty acids — with official results expected by 2013.

Bioavailability The bioavailabilty of lutein is an important aspect of research into the effectiveness of its supplementation. Low serum levels of lutein are associated with increased AMD risk, which is particularly significant when, as Prof. Edward P. Norkus, PhD, from the Montefiore Medical Centre in New York, stated: “Current data suggests great variability in serum response following lutein supplementation from various sources.” His latest findings, however, reveal a significantly greater relative serum lutein response from supplements containing free lutein, such as FloraGLO, than from those containing lutein esters. In addition to the lutein form, formulation methods also have a substantial impact on its bioavailability. Wolfgang

Schalch, PhD, from DSM, presented on recent research that has revealed the superiority in bioavailability provided by the use of Actilease beadlet technology that formulates lutein into micro-sized particles protected in a watersoluble shell.

Conclusions The congress concluded that the blue light filtering and antioxidant properties of lutein and zeaxanthin protect against damage caused by reactive oxygen species in the retina and have a positive effect on different eye health parameters. Furthermore, there have been many studies undertaken that have demonstrated increased MPOD levels, improved visual function and reduced risk of age-related eye diseases that are specific to FloraGLO Lutein. As a result, the increased consumption of lutein may be seen as a safe, easy and effective measure to improve macular health. Further studies look set to provide more evidence regarding the efficacy and benefits to eye health associated with longterm Lutein supplementation.

For more information Royal DSM NV is a global science-based company that’s active in health, nutrition and materials (www.dsm.com). Kemin Industries (founded in 1961) provides solutions specifically developed to provide nutrition and health benefits for humans and animals, distributing approximately 500 specialty ingredients to the food, health, nutrition and beauty industries (www.kemin.com).

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