NBT May 2012

www.nutraceuticalmag.com nutraceutical business & technology

Functional ingredients Boosting the benefits of omega-3s Nature’s secret: arionaberries Volume 8 Number 3 May/June 2012

Volume 8 Number 3

REGULATION Transparency, needed now!

sports nutrition May/June 2012

A new kid in the blocks

INDUSTRY issues

Changing the pill paradigm

DRINKS WITH A The latest range of sports and recovery beverages makes waves

NBTA 2012 preview Going for gold

ISSN 1745-8307

Vitafoods Europe and Finished Products A powerful Expo platform • ingredients • functional foods • nutraceuticals • supplements • raw materials •

The perfect recipe for an active, healthy lifestyle starts here.

As top performers in the areas of sports nutrition, weight management, clinical nutrition and infant health, our family of branded ingredients delivers the nutritional benefits that today’s consumers demand from their wellness products.

Naturally sourced, clinically proven and scientifically based, our ingredients support and enhance your functional foods, beverages or dietary supplements.

Find out how to add vitality to your company’s performance with nutritional solutions from Stepan Lipid Nutrition.

Stepan Specialty Products B.V. Museumlaan 16 1541 LP, Koog ann de Zaan The Netherlands Phone: +31 (0) 75-727-1000 Email: info@lipidnutrition.com

*Trademarks owned by Stepan Specialty Products LLC.

Visit us at Vitafoods Europe, May 22-24, Booth #1373

Volume8 Issue3

contents

May/June 2012Contents

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58 46

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04 Vitafoods Europe and Finished Products Expo: The Most Powerful Nutraceuticals Platform Lynne Evans

GOED Report

26 How Much EPA and DHA is Enough?

Adam Ismail and Harry Rice

Executive Profile

28 Operating in the Wriggling Room Dr Kevin Robinson with Dr Atle Skattebol

Opinion

30 Constant Industry Transparency: The Time is Now

52

Roy Henderson

Functional Beverages

Sports Nutrition

Sybille Buchwald-Werner, Cynthia Suarez and Katie Beckett

Filip Van Hulle

34 Marula Fruit: The Next Beverage Innovation

38 The Whey to Long-Term Wellness Suzane Leser

40 Cholesterol Reduction in Beverages and Spreads Olivier du Châtelier

42 The Rise of Relaxation Drinks Harmony Villemin

46 Going for Gold Bruce Bennett

Functional Ingredients 48 Strength in Numbers, Part II

Dr Fernando Schved, Batia Hassidov and Sharon Galperin

52 Boosting the Benefits of Omega-3s with Olive Polyphenols Carlos Peña

56 What’s Good for the Goose Dr Puya Yazdi

58 Nature’s Secret Melanie Bush

62 Sports Nutrition: A New Kid in the Blocks

Market Trends

66 Health and Wellness Trends in Scandinavia

30

Ewa Hudson

70 A Prescription for Lower Carbon Healthcare Dr Paul Taylor

74 Prostate Health Cocktail: Not Your Average Vitamins!

76

Dr Cheryl Strelko

Technology

76 Recent Advances in the Analysis of Stevia Leaf Extracts Christopher Crafts, Deanna Hurum, Jeffery Rohrer and Ian Acworth

Last Word

76 Innovate to Survive

20-25

Chris Lee

Industry Issues

78 Changing the Pill Paradigm George Pontiakos

NBT

20-25 N A Previe w BTA II: G Dr Kevin oing for Go ld Robinso n

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A Powerful Platform T

he most important global event to concentrate exclusively on nutraceuticals, raw materials and functional food and drink ingredients — Vitafoods Europe — is set to celebrate its 15th anniversary by staging its biggest edition to date. Vitafoods Europe and the colocated Finished Products Expo, which take place from 22–24 May 2012 at Palexpo, Geneva, are on course to exceed last year’s record-breaking event, which saw more than 10,000 attendees benefit from cutting-edge insights from leading industry experts.

Vitafoods Europe caters to a rapidly growing nutraceuticals industry, projected to be worth $207 billion by 2016. Set against the background of a booming market, both events will welcome hundreds of ingredient suppliers, dietary supplement manufacturers and equipment and service providers during their course, along with thousands of industry experts who will be discussing the key developments that are shaping the market. The event will welcome international brands such as BASF, Biofortis, Croda Europe, Davisco Foods International, Danisco, DSM Nutritional Products Europe, Frutarom, Glanbia Nutritionals, Naturex and Ocean Spray International, whereas exhibitors at Finished Products Expo include Ubifrance, Bariatrix Europe, Medex, Nature’s Plus and NOW International. Visitors to both shows will also have the opportunity to do business with and discover new ingredients from global nutraceutical companies; exhibitors from a range of countries, including China, Israel, Croatia, Poland, Slovenia, South Africa and New Zealand will be present across the two shows.

The New Products Zone, located at the show entrance, will act as a guide for visitors wishing to plan a route that encompasses new products of interest — and more than 150 of them are expected this year. Highlights will include BioActor’s Bonolive, the market’s only bone health ingredient made from olive polyphenols, and DDS Plus 3, which contains the award-winning formula found in Probioplus DDS, from UAS Laboratories/Probiotic Co. New for 2012, poster sessions on the exhibition floor will give researchers an opportunity to share their innovative projects with other potential collaborators, researchers and commercial partners or investors. Chris Lee, event director of Vitafoods Europe, said of the new feature: “It is essential to support fresh ideas and new projects that will keep the nutraceutical industry as forwardthinking as possible. The poster sessions will provide an opportunity for scientists from around the world to demonstrate their original research and for visitors to learn more about their results and how it could affect product development in the future.”

The free-to-attend supplier seminars will give visitors the chance to see some of the latest products in action and obtain detailed information on the benefits to their business. More than 25 sessions will take place during the 3 days, including Chris Kilham from Naturex discussing medicine hunting for superplants, Véronique Fabien Soulé from Rousselot examining the nutritional properties of Peptan Collagen Peptides in the framework of the EU health claims regulation and Dr Frank Shönlau from Horphag Research investigating Pycnogenol and its role in improving cognitive function.

www.nutraceuticalmag.com May/June 2012

VitaTrend, a joint initiative between Vitafoods and Innova Market Insights, will examine emerging trends that will impact new product activity in the nutritional and functional food market: at the forefront of this year’s sessions will be the impact of the publication of the European Commission’s ‘union list’ for generic health claims. VitaTrend will feature daily 30 minute presentations by Innova Market Insights experts from 10.30–11.00 and 16.00–16.30 and visitors can take part in an interactive tour of these trends. In addition, the international food and nutrition policy consultancy EAS will offer visitors free one-on-one sessions tailored to the needs of their companies, which will include advice on regulations regarding product formulas and labelling to assist marketing plans.

Also on the show floor, Mintel’s Product, Ingredient and Consumer Insights Pavilion will feature presentations and tasting sessions that investigate trends by bringing research to life; company experts will provide real market examples and forecast how trends will shape the future of the industry. Alongside this, the International Pavilions will enable visitors to meet with new suppliers and learn about local products from regions throughout the world, including China, France, India, Belgium, Serbia, Korea and the USA, whereas the Service Pavilion will help visitors to source services — from regulatory experts to contract manufacturers.

The colocated Finished Products Expo will host its own dedicated features, including the New Products Zone, which offers visitors a guide to where the latest innovations are being showcased. A highlight of this year will be NEWtritious’ Kherb Appeal, an instant pudding that curbs appetite and provides an excellent source of fibre, vitamins and minerals. Also expected to be popular with visitors is the Tasting Bar @

staff

Volume 8 Issue 3 May/June 2012 ISSN 1745-8307

Contributors Editorial Director

General Manager

Kevin Robinson +44 (0) 1392 202 591 kevin.robinson@via-medialtd.com

Miranda Docherty +44 (0) 1372 364 122 miranda.docherty@via-medialtd.com

Assistant Editor

Sales

Charlotte Hodgson +44 (0) 1372 364 130 charlotte.hodgson@via-medialtd.com

Gill Healy +44 (0) 1372 364 128 gill.healy@via-medialtd.com

Art Director/Production

Financial Officer

Paul Howells +44 (0) 1372 364 126 paul.howells@via-medialtd.com

Cherelle Saunders +44 (0) 1372 364 123 cherelle.saunders@via-medialtd.com

Web Design/Marketing Claire Day +44 (0) 1372 364 129 claire.day@via-medialtd.com

FPE, which provides the opportunity to sample the latest innovations in the functional food and drinks market and vote for the best product in each category.

Vitafoods Europe Conference

Away from the show floor, Vitafoods will host its annual scientific and commercial conference with an agenda that has been shaped and peer reviewed by its new executive advisory board, which consists of renowned scientists and commercial experts. More than 40 presentations will discuss consumer trends, the global performance of functional food and drink, health claims, clinical trials and human testing, brain and mind health and regulation. Delegates will be able to learn about essential nutrients and cognitive function, generating food structures to aid consumer weight management and how to better measure food quality.

Dr Stephen DeFelice, renowned for coining the term ‘nutraceutical’ in 1989, will lead the conference discussing the past, present and future of the nutraceutical revolution. Other speakers include representatives from Coca-Cola Europe, the European Food Information Council, Leatherhead Food Research, Solae Europe, Vital Solutions, Hellenic Food Authority (EFET) and Stratum Nutrition. “The conference is a respected forum for scientific developments and, with the peer-reviewed content, we’re confident that the programme for 2012 will have sessions to help R&D, brand and corporate management to develop products in new markets and discuss new applications,” commented Lynne Evans, conference producer.

Visitors, exhibitors, delegates and speakers will also be able to attend the Vitafoods Europe Discussion Forum, which regularly attracts more than 300 participants, chaired by Guy Valkenborg from EAS and featuring a panel of leading experts in the fields of marketing, regulation, ingredients and finished products. The 2012 discussion will focus on “The Future of Innovation in Europe: Key Areas of Opportunity and Concern in the Next Five Years.’

For more information

For further details about Vitafoods Europe and Finished Products Expo, visit www.vitafoods.eu.com or www.finishedproductsexpo.com

Editorial Advisory Board Susanne Fässler Marketing Communication Manager Frutarom Switzerland Ltd

Theodor Graser Head Pharma Industry DSM Nutritional Products Ltd Denzil Phillips Founder Denzil Phillips International

Jörg Grünwald President Analyze & Realize ag

Pedro Vieira Marketing Manager Kemin Health Europe

Dr Michelle H. Jones Manager, Regulatory and Scientific Affairs Archer Daniels Midland Company

Robin Ward Managing Director Excelsa Pharmaceuticals Sagl

John Kurstjens Marketing Manager Lipid Nutrition

John Wilkinson Consultant Phytochemist and Director Herbal Sciences Int. Ltd

Chris Lee Event Director IIR Exhibitions

Dr Paul Berryman Chief Executive Leatherhead Food International

Ulla Freitas Manager Scientific Affairs, Nutrition Lonza AG

Norbert Weitkemper Managing Director Vital Solutions GmbH

To subscribe Professionals working within the industries we cover may purchase a year’s subscription by sending a cheque for £100.00 made payable to Via Media UK Ltd, Wesley House, Bull Hill, Leatherhead, Surrey, KT22 7AH No part of this magazine may be reproduced, stored in a retrieval system or transmitted in any form without permission.

Copyright © 2012, Via Media UK Ltd. All Rights Reserved The publisher endeavours to collect and include complete, correct and current information in nutraceutical business & technology, but does not warrant that any or all such information is complete, correct or current.

The publisher does not assume, and hereby disclaims, any liability to any person or entity for any loss or damage caused by errors or omissions of any kind, whether resulting from negligence, accident or any other cause. nutraceutical business & technology does not verify any claims or other information appearing in any of the advertisements contained in the publication, and cannot take any responsibility for any losses or other damages incurred by readers in reliance on such content.

May/June 2012 www.nutraceuticalmag.com

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Oh Soy Effective

ADM (Stand 1449) will be showcasing CLARISOY 100 — the world’s first vegetable-based protein that offers clarity and high-quality protein nutrition — to the European market. CLARISOY 100 is the first isolated soy protein that enables protein fortification in transparent and refreshing low pH beverage systems, such as sport and recovery drinks. The ingredient is also 100% soluble and transparent for beverage systems with a pH of less than 4.0, so manufacturers can comfortably formulate up to 10 grams of protein and maintain beverage clarity. In addition, the company will showcase its CardioAid range of phytosterols and phytosterol esters, which have approval as novel food ingredients and can be used in a variety of food and beverage applications targeted at reducing blood cholesterol levels. They help manufacturers of functional foods to capitalize on the approved EU health claim that states the following: “Plant sterols have been shown to lower/reduce blood cholesterol.”

As part of its effort to promote good health, ADM will also be offering Novasoy soya isoflavones, which help to combat the tell-tale signs of the menopause, including hot flushes, and are suitable for supplements, functional foods and beverages. Another highlight will be Novatol, a natural source of vitamin E, which is needed by the body to protect cells and support natural defences. Also on show will be the Decanox range of natural antioxidants for food, feed and cosmetic use (www.adm.com)

The Whey Forward

Leading whey protein supplier, Carbery (Stand 1125), will be showcasing its nutritional expertise in healthy ageing. The company’s range of whey protein concentrates, isolates and hydrolysates are ideal for enriching a range of functional and everyday products to promote health and wellness for the over50s. Highly bioavailable and rich in branch chain amino acids (BCAAs), whey protein helps to build skeletal muscle when consumed as part of a healthy and active lifestyle. Sarcopenia, the natural process of muscle wastage that results from ageing, is a growing concern for people aged 50 and above. On its stand, Carbery will be highlighting the important link between protein consumption and the promotion and maintenance of muscle mass and discuss its extensive knowledge and in-depth expertise in the strength-building properties whey protein. Visitors will also learn about how Carbery’s Carbelac, Isolac and Optipep ranges can be used to create a variety of appealing products that meet consumer demand for condition-specific foods and beverages.

www.nutraceuticalmag.com May/June 2012

“Whey protein is a key nutrient in building and maintaining muscle mass,” comments Noel Corcoran, sales and marketing director of Carbery Food Ingredients. “At Vitafoods, we will be demonstrating how our ingredients and deep understanding of sarcopenia can help food manufacturers to develop consumer-winning health and wellness products. A number of studies indicate the importance of consuming protein in conjunction with physical exercise and a balanced diet — and an ageing population means that limiting the impact of sarcopenia is now more important than ever. Our diverse ingredient portfolio can respond to this need and also cater for the popular sports nutrition market where muscle and strength building is just as important.” Carbery’s whey protein ingredients can be incorporated into a range of products including supplements, meal replacements, bars, beverages, soups and sauces. Customers can draw on the joint expertise of Carbery and its sister company Synergy, which specializes in flavours, to create appealing products that enable consumers to boost protein intake without compromising the eating experience (www.carbery.com)

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The Bridge to Health

The integration of Danisco has made DuPont (Stand 1226) one of the world’s premier specialty food ingredients and food safety businesses, creating unprecedented opportunities for manufacturers of foods, beverages and dietary supplements. Following 2011’s acquisition, DuPont has built on the already well-established offering in the area of nutrition and health to offer customers a more extensive product portfolio backed by greater resources and a stronger science focus than ever before. “Given the vast capabilities of our Nutrition & Health team, I am confident in our ability to bring even greater benefits to our customers and partners,” said Craig F. Binetti, president, of DuPont Nutrition & Health. “We’re leading the way with a wide product range, strong application expertise and unrivalled food and nutrition science.”

Focusing on the desires and needs of consumers, the company will continue to use several condition-specific platforms as the basis for its nutrition and health portfolio. These platforms encompass key areas such as cardiovascular, digestive, immune and bone health, in addition to weight management and sports performance. Visitors to the stand will be able to talk to experts about health-promoting ingredients from the DuPont Danisco range, including HOWARU premium probiotics and PinVita phytosterols (www.dupont.com)

A Fruitful Future

Frutarom Switzerland Ltd (Stand 2134) is set to launch a comprehensive range of ingredients for the immune health market, including innovative ingredients for the daily support of the immune system. The company’s goal is to provide its customers with a full range of natural solutions to target a range of immune health concerns, rather than focusing on just one aspect of this category. Its strategy is to offer specific solutions for key health indications — not to simply sell a catalogue of miscellaneous products. The ingredients in this new range are versatile enough to allow the creation of purpose-designed formulations.

Frutarom will showcase some of its latest research findings at the show and invites visitors to sample of a variety of product applications based on its ingredients. Its goal — to become the preferred partner for successful, tasty and healthy products — reflects its commitment to deliver the most flavourful and healthy solutions to customers. Frutarom sees research and innovation as a core competency and its global R&D team benefits from a wealth of experience accumulated during 75 years. The company has the distinct advantage of a broad range of in-house raw materials and close collaborations with universities, research institutes and start-ups (www.frutarom.com)

www.nutraceuticalmag.com May/June 2012

Licorice Extract Enters the Ring

Kaneka Pharma (Stand 1436) will showcase new application possibilities for its patented licorice extract Glavonoid, which has recently been granted novel food status by the European Commission. The polyphenols, derived from licorice root (Glycyrrhiza glabra L.), have been found to ameliorate abdominal obesity and target visceral fat thanks to a unique two-way efficiency profile. Glavonoid can be used in functional food applications such as milk, yoghurt and fruit- or vegetable-based beverages, in addition to food supplements aimed at the weight management and bodyshaping markets. Moreover, Kaneka will present new application forms for coenzyme Q10 and its active form, Ubiquinol.

An advanced, patented manufacturing process ensures that Glavonoid does not contain any glycyrrhizinic acid, which is regarded as having cortisone-like side-effects and is the reason that licorice has not been used more widely thus far. Glavonoid contains 30% licorice glabra polyphenols, is standardized on 3% Glabridin and is proven to be safe. Glavonoid offers unique dual support in fighting visceral fat: on the one hand it increases the body’s own fat-burning ability and on the other hand it decreases fat synthesis by down-regulating genes that are involved in fatty acid development. As visceral fat is significantly involved in developing metabolic syndromes and obesity, slimming and weight management are major driving forces in today’s markets, products containing Kaneka’s licorice extract hold great potential.

Visitors to the stand will also be able to gain insights into the latest application forms for Kaneka Q10, a naturally derived coenzyme Q10, and its active form, Ubiquinol (Kaneka QH). The natural instability of Ubiquinol has traditionally posed a great challenge to product developers: as a powerful antioxidant, it reacts immediately with oxygen when exposed to air and loses its outstanding bioavailability.

Kaneka has overcome this problem and succeeded in producing a stable form for the first time. The company will present new application forms for Ubiquinol, such as recently developed pellets and sticks (www.kaneka.be)

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Tea at Taiyo

Taiyo GmbH (Stand 1360) will be launching a completely taste-free green tea extract at Vitafoods 2012. Sunphenon XLB-100 delivers the full benefit of green tea to any beverage application and removes the characteristic bitter taste that is often associated with it.

This latest addition to Taiyo’s expert portfolio of health ingredients for food and beverages highlights the company’s commitment to providing manufacturers with ingredient solutions that mirror consumer demand for The Building Block of Innovation health without forfeiting taste. Taiyo’s range of natural green tea extracts has been Manufactured and marketed worldwide by Rousselot (Stand 1341), Peptan developed through extensive research into the properties of camilia sinesis — or collagen peptides are enjoying increasing success, which can be linked to green tea — and contains highly purified green tea polyphenols, shown to have several scientific studies that have proven its effectiveness in addition to its easy numerous biochemical and physiological benefits. integration into applications. The same collagen that’s found in human bones and Sunphenon offers antioxidant, antimicrobial, deodorant and thermogenic (or skin, Peptan helps to fight skin ageing and improve skin hydration. Studies have fat burning) activities, whereas Suntheanine, through the amino acid L-theanine, demonstrated that a dose of 10 grams of collagen peptides a day meets the daily promotes clarity of thought, concentration and reduced reaction to stress. adult requirement for beneficial effects for joint and bone health. A 97% pure Completing the range of health solutions are Sunfiber, a 100% natural soluble protein, Peptan collagen peptides have a satiating effect, may play an important role in weight maintenance programmes and can also be used in sports nutrition to fibre and Sunactive, a zinc delivery system for successful application in foods, beverages and supplements. “We are very excited to be launching this innovation help to restore muscles after exercise. at Vitafoods,” commented Josef Skrna, marketing manager at Taiyo GmbH. Available as a powder in different molecular weights and densities, Peptan is easy to integrate into products; Rousselot will be highlighting its new formulations “Advances in science and technology have furthered our understanding of the body and its responses and facilitated the development of ingredients that meet at the show, including nutritional beauty, slimming and sports nutrition bars. the ongoing demand for improved health and well-being. In supplying this truly Several examples of antiageing masks and serums for cosmetic applications ‘tasteless’ ingredient, we hope to expand the new product development business will also be demonstrated. Visitors interested in Peptan can attend Rousselot’s possibilities of our customers.” Representatives from Taiyo will be available for 30 minute seminar on “The Nutritional Properties of Peptan Collagen Peptides in consultation throughout the event and visitors to the stand can learn about the the Framework of EU Health Claim Regulations,” which will be led by Veronique benefits of green tea in fortified foods and beverages.

Fabien-Soulé, Rousselot’s regulatory affairs director (www.rousselot.com)

Aenova – Your Global Partner for Solid Dosage Forms The Aenova Group is a leading service provider for the development and manufacturing of solid dosage forms such as soft and hard capsules, tablets, VegaGels® and effervescent products. With a broad offering of food supplements and OTC products, Aenova is your partner of choice in developing innovative business solutions for the international healthcare market.

www.aenova.de s at u t i Vis foods Vita 1464 th boo Members of the Aenova Group

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An Ocean of Knowledge

Ocean Spray Ingredient Technology Group (Stand US14) will be revealing its latest cranberry research at the show. The cranberry’s potential role in supporting wholebody health is well documented, supported by a substantial bank of more than 50 years of scientific research. The most recent findings add further weight to the cranberry’s holistic health proposition and will help to extend the knowledge of its health benefits. This research follows the recent publication of a study by Finnish researchers, which shows that cranberry juice may reduce recurrences of urinary tract infections in children. The results found that, compared with placebo, regular drinking of cranberry juice lowered the number of UTI recurrences in children by 43% and reduced the need for antibiotics by 34%; the equivalent of 6 days per patient per year. The cranberry is recognized for its role in maintaining urinary tract health in adult women and these findings demonstrate that its juice can also benefit younger patients who might otherwise face long-term antibiotic use.

Christina Khoo, senior manager of research sciences at Ocean Spray, commented: “Ocean Spray is committed to supporting independent research into the health benefits of cranberries and we have seen a number of significant scientific breakthroughs in recent years. Last year, we announced our strategic partnership with Artemis International, specialists in phytonutrient ingredients for nutraceutical applications. This has cemented our commitment to continuing to drive the commercial growth of cranberrybased nutritional products and we look forward to sharing our latest advancements with the nutraceutical industry at this year’s show.” Ocean Spray has also announced its collaboration with Complete Phytochemical Solutions, LLC on a project to improve the accuracy of measuring and quantifying PACs in cranberries. Through the partnership, Ocean Spray hopes to develop a new cranberrybased PAC standard, derived from cranberry fruit.

Accurate quantification of PAC content in cranberry products is a vital component in establishing intake guidelines for consumers and is essential for monitoring the efficacy and shelf-life of dietary supplements (www.oceanspray.com)

Specific Needs, Specific Foods

This year, Roquette (Stand 1454) will highlight a selection of plant-based ingredients that will be of particular interest to innovative creators of sports and weight management food formulations and those wishing to offer products that support ageing. A pioneer in numerous sectors, including oral health and foods for particular needs, Roquette has been closely involved in the nutritional and functional improvement of foods and pharmaceuticals for more than 50 years.

Focused on the naturalness of its offerings, Roquette food experts will present a selection of functional ingredients backed by innovative concepts and by nutritional data. Delivering clear breakthrough solutions, they will open up new opportunities for formulators of functional foods and nutraceuticals who wish to meet consumer demands reliably.

Roquette’s stand design will be based on three themes to maximize clarity, immediacy and visitor satisfaction: keep shape (weight management solutions), keep fit (sports nutrition solutions) and keep young (healthy ageing solutions).

For instance, visitors to the weight management area will be able to sample an innovative quick-dissolving powder mix that company experts define as “the twice-a-day boost to feel full for longer.” The mix, which contains Nutriose soluble fibre, makes an attractive fruity drink with the clinically proven ability to induce a satiety effect. In the sports nutrition solutions area, visitors will find a prototype, AminoSustain, which strengthens the sustainable-innovation possibilities of Nutralys and is a blend of whey and Nutralys pea protein that offers digestion rates tailored to optimize amino acid supply and develop muscle for recovery and training periods. Thanks to this protein combination, the product concept delivers organoleptic, nutritional and technological benefits. In the healthy ageing solutions area, there will be a tasty pana cotta-like dessert that fully responds to specific needs of seniors. This high-protein source of fibre is free from lactose and dairy and constitutes a new way to provide older people with a highly reliable and 100% vegetable dessert.

Each of the solutions areas will therefore allow visitors to discover new formulation ideas that are backed by specific ingredient characteristics — and that’s not all: those seeking formulation help will find solutions tailored to their needs. Finally, thanks to the comprehensiveness of its range of plant-origin excipients, Roquette can offer solutions that meet the requirements of different manufacturing processes (www.roquette.com)

www.nutraceuticalmag.com May/June 2012

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Lyc-O-Matic

LycoRed (Stand 2069) will reveal the results of new studies into Lyc-O-Mato, the natural lycopene extract for cardiovascular and prostate health. Essential hypertension is one of the most common cardiovascular health problems in the developed world and is an indisputable risk factor for morbidity and mortality. At the Vitafoods Europe Conference, Dr Esther Paran will introduce the conclusions of this and other clinical research into Lyc-O-Mato’s abilities to help to protect against prehypertension and hypertension as cardiovascular risk factors and explain the effect of tomato and tomato products, such as Lyc-O-Mato, as important antioxidant sources in the diet. Included will be a description of her pioneer study on tomato extract capsules for the reduction of blood pressure in hypertensive patients and she will demonstrate the superior beneficial effect of natural lycopene extract on blood pressure compared with synthetic lycopene. LycoRed’s Lyc-oMato natural tomato complex contains a full complement of carotenoid antioxidants and is ideal for creating products to help to prevent cardiovascular and prostate disease (www.lycored.com)

Weighed in the Balance

Solbar (Stand 2153) will be presenting a newly developed line of soy-protein isolates for the weight management market, which will include innovative textured products designed for a complete healthy and balanced meal that helps to ensure an optimal daily consumption of protein. Many studies have shown that high-protein meals are more satisfying than high-carbohydrate or high-fat meals when based on measures of satiety. Soy protein isolate is a naturally complete protein with a protein digestibility corrected amino acid score (PDCAAS) of 1.00 and a low glycaemic index.

The new line is based on two fundamental principles: taste and health. Solbar Q741 is a low-viscosity soy isolate with a great flavour profile that has excellent suspension properties and can be easily introduced into nutritional shakes and recovery meals. Solbar Q813 will be demonstrated in bar applications (in both protein and cereal bar formats) to highlight the high protein levels that can be achieved by using Solbar’s hydrolysed, low-viscosity soy protein isolate, without an adverse effect on shelf-life or flavour. As a global leader in the soy ingredients market, Solbar is committed to the highest-quality soy protein solutions. The company aims to improve the health, wellness and nutrition of people around the world by expanding its range of soy proteins and soy isoflavones (www.solbar.com)

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Thank you for noticing.

Nutrition Business Technology Award for Most Innovative Ingredient, presented at Vitafoods

The Frost & Sullivan 2011 Global Eye Health Ingredients (Lutein & Zeaxanthin) Product Differentiation Excellence Award

OmniActive Health Technologies continues to receive global recognition and acclaim. Recently, OmniActive received two awards for ingredient and technology innovation.

Capsimax™ and Lutemax 2020™ showcase OmniActive’s breakthrough

technologies and formulations that enhance the body's ability to absorb

omniactives.com

and utilize health promoting ingredients. By delivering nutrients in

bioavailable, scientifically validated and stable forms we provide our

valued customers with the innovative partnership they require to develop truly outstanding consumer products.

For more information on our award-winning ingredients, visit capsimax.com or lutemax2020.com.

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Polar Innovation

Polaris (Stand 2032), a major player in the nutritional lipids arena, offers a range of health ingredients based on oils that are rich in polyunsaturated fatty acids. Under the banner, “Omega-3 at all steps of your life,” the company is targeting women’s health with an exclusive marine oil; this high quality oil is rich in omega-3 DHA and — produced using a high technology deodorization process — has a neutral taste. Any woman, whatever their physiological situation (pregnancy, breastfeeding or the menopause), can enjoy the inconvenience-free benefits of marine omega- 3. Regarding child health applications, the same innovative lipochemistry technology has been used to produce a DHA-rich marine oil with an orange flavour.

Polaris is an expert in lipid engineering and, thanks to its patented QualitySilver process, which stabilizes polyunsaturated-rich oils and delays the beginning of oxidation, can provide pure, highly stable marine and vegetable oils. The organoleptic and nutritional properties of these oils are thus preserved.

The company has also developed its technological know-how and also offers bespoke molecular distillation services, courtesy of new state-of-the-art facilities and custom manufacturing skills: high value health ingredients are purified, concentrated and deodorized in a green chemistry environment. Armed with this capacity, and anticipating future nutrition industry requirements, Polaris offers innovative and effective solutions for any specific development project. Polaris is a prime partner for specialists in the nutraceutical, food-processing, cosmetics and pet supplement sectors (www.polaris.fr)

Functional Indulgence

Leading bar manufacturer VSI (Stand 3030) presents its innovative range, including slimming and meal replacement bars, sports bars, beauty bars and other functional variants. All bars are composed with scientifically backed functional ingredients and offer a truly indulgent experience, be it sweet or savoury. In addition, premium bars that simply link healthy snacking and great taste will be presented. Combining current market trends and innovative ingredients, VSI has recently developed a savoury meal replacement bar — a breakthrough that embraces the trend of hearty snacks — and wasabi, bacon, pizza and chili samples with crispy textures are currently available. With an eye on the desires of sweet-toothed consumers, VSI has also created bars with delicious jelly layers for pure indulgence. In addition, the Dutch company is formulating a recipe for a thick jelly layer made exclusively from natural syrups.

The VSI range comprises bars that are high in protein, low in carbohydrate, low in sugar or that contain innovative slimming ingredients, including the following: Pinnothin, which is derived from the seeds of the Korean pine nut tree and promotes a feeling of satiety; L-carnitine, which aids fat burning; caffeine, which provides a natural boost and antioxidants to support the immune system.

Serving as meal replacements for dieters, performance supporters for athletes or simply as pocket-sized snacks, VSI’s bars have a convenient, nutritious and above all tasty appeal that meets the demands of both customers and consumers completely (www.vsi.nl)

A Sunny Outlook

Consumers are fed up of slimming in pain! Combining great taste and nutritional expertise, Nutrisun (Stand 3323) will offer its latest innovation: a slimming breakfast. The company’s breakfast products (PanMix, YogMix and a few surprises) are easy to prepare, high in protein and delicious. Nutrisun channels its nutritional expertise into developing innovative products and for the last 15 years has been offering the benefit of its substantial experience to help its clients to develop tailormade dietetic products for the weight management, sport, well-being and health markets (www.nutrisun.fr)

From Micro to Macro

The Relaxation Ingredient

Always willing to offer new market opportunities to its customers, Ingredia Nutritional (stand 1338) has developed a full range of relaxing drink concepts featuring Lactium, which it will be presenting at the show. The stress-moderating properties of this 100% natural ingredient have been clinically proven as effective by many studies, the latest in 2010, at different dosages. This innovative range of relaxing drink concepts features beverages that target acute, moderate or chronic stress symptoms among different populations depending on their Lactium dosage, type, flavour and time of recommended intake. Proposed as ready-to-use concepts, the drinks are designed to be source of inspiration for customers and Relax Water, a 500 ml translucent, flavoured, refreshing drink featuring 300 mg of Lactium, will be available to taste at the stand. This product is suitable for all age ranges and is designed to help the whole family manage chronic stress, thus increasing quality of life (www.ingredia.com).

www.nutraceuticalmag.com May/June 2012

Kelatron (Stand 2290) will use the event to stage the European launch of its unique range of micro and macro nutrients, produced in collaboration with Innophos, its parent company. The combination of Kelatron’s expertise in high-quality mineral chelates and Innophos’ capabilities in phosphate fortification provides manufacturers of supplements, sports nutrition and functional food and drink products with access to an industry leading selection of premium ingredients.

Highlights include Kelatron’s K-Pure portfolio, Innophos’s award-winning Versa-Cal Clear and TCP-DC, a new tricalcium phosphate for compressed and chewable tablets.

Exhibiting for the first time at Vitafoods, the company will present a wide range of fully reacted, highly stable and bioavailable chelates such as K-Pure calcium bisglycinate. Calcium is valuable in muscle function, nerve transmission, connective tissue maintenance, weight management and the regulation of blood pressure in addition to bone and tooth health. Manufacturers can combine the ingredient with other chelated minerals to develop supplements for specific health conditions or life stages, such as heart health or pregnancy. K-Pure chromium picolinate is a source of chromium, which is critical to optimizing insulin levels and its combination with picolinic acid, the human body’s natural chelator, maximizes the bioavailability of chromium and other vital trace elements such as zinc, manganese, copper, iron and molybdenum, according to early research. Suitable applications include sports nutrition and weight management products.

Visitors interested in antioxidants will be able to learn more about Kelatron’s Bio Sel-5000. This l-selenomethionine is a highly bioavailable and easily utilized source of selenium, which various independent studies have revealed to play a valuable role in the prevention of cancer. Latest statistics show nearly 13 million new cases of cancer were diagnosed in 2008, so there is considerable consumer, political and medical interest in finding new and better ways to prevent it. Also featured at the stand will be Versa-Cal Clear, the acclaimed calcium phosphate for clear beverages that has no effect on the colour, taste or mouthfeel of the finished product. Highly soluble, transparent and specifically formulated for this growing market, it is an excellent source of calcium and phosphorous; nutrients that are essential to bone and dental health. Technical and applications experts will be available throughout the exhibition to consult visitors on suitable ingredients for their required product profile or to discuss new projects (www.kelatron.com)

New Concepts from Laboratoire PYC

Laboratoire PYC (Stand 3120), the French supplier of high-protein products and food supplements, will once again be present at the Finished Products Expo to introduce its latest innovations. Visitors will discover innovative solutions for weight control, including the company’s latest ready-made ‘Soup-in-a-Cup’ natural concept — a healthy mix of vegetables and satiating proteins. The company has launched a seven vegetable soup that contains more than 17 g of protein per cup with a reduced amount of sugar and fat (138 kcal per cup). The product contains no colours or preservatives, only natural flavours and the concept has been a success. Even more recent formulae will be on show at the stand. The company has also added new instant high-protein powder mixes to its range of weight-management solutions — 59 powder mixes are now available in stock.

In addition, Laboratoire PYC has just introduced instant, high-protein cakes, which can be prepared in less than 2 minutes using a microwave and may be eaten by consumers without guilt: one portion provides fewer than 2 g of sugars and 18 g of high-quality protein. Laboratoire PYC is also a leading European supplier of food supplements in stick-packs; new instant beauty drinks in this format will be introduced at the stand (www.laboratoire-pyc.com)

SOFRIENDLY SOHEALTHY SOEASY

Nature got it right !

Advanced Gelatin Solutions

GELITA (stand 1248), a major player in the global collagen protein market, will present Bioactive Collagen Peptides, which stimulate body functions, and GELITA RXL gelatin for the improved shelf-life and stability of hard and soft capsules. Verisol, administered orally and easily incorporated into a variety of products, influences the skin’s collagen metabolism from the inside to increase skin elasticity and reduce wrinkles. Fortigel stimulates the cartilage cells to increase the production of both collagen and proteoglycans, the two major components of cartilage, to improve joint mobility, reduce pain and thus provide a higher quality of life. Also to be presented is Peptiplus, which provides the healthy, purine-free nutrients required for the many processes that take place in muscles and cells. The collagen peptides replace energy used up in training, are good for the figure and easily absorbed by the body so that its energy is readily available. Whether in energy bars or sports beverages, the protein provider is perfectly soluble and excellent in taste.

GELITA RXL is a specially optimized gelatin that reduces the cross-linking of gelatin capsules. It increases dissolution properties, improves shelf-life (especially at high temperatures and humidity) and allows manufacturers of H&N, OTC or Rx products to explore new fill materials that were previously thought impossible to encapsulate. As the first and only pure gelatin solution to this problem, the ingredient is protected by US Patents 7,485,323 and 7,897,728 and other related international patents have already been granted or are pending.

SO FRIENDLY: Ingredient from non-GM corn or wheat & labeled as a soluble fibre.

Its excellent digestive tolerance ensures consumer comfort. SO HEALTHY: Clinicals show prebiotic, satiety & weight management benefits. Useful to enrich fibre and to lower sugars, fats & calories. SO EASY: High process stability assures no fibre loss.

Natural tasting & fast dissolving, easy to use in any application!

T US A S T I S I V D FOO 12 VITA – 24, 20 o 22 exp May VA, Pal 4 E 5 GEN and 14 t S

For more information, please visit

www.nutriosesolublefibre.com

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A Strong Standard

Having helped food, beverage and pharmaceutical manufacturers to introduce or improve more than 30,000 products in its 25 year history, Fortitech (Stand 2053) continuously sets the standard in the field of fortification with unparalleled expertise. Solely dedicated to the development and manufacture of custom nutrient premixes, Fortitech can source in excess of 1400 ingredients from a comprehensive selection of vitamins, minerals, amino acids, nucleotides and nutraceuticals, enabling manufacturers to target the specific needs and demands of any consumer demographic with strategic nutrition. The company’s premixes are used in a variety of applications, including baby formulas, cereals, bars, dairy products, nutrition and sports drinks, juices, snacks, waters, candies, spreads and supplements. During the event, Fortitech will be sampling an energy enhancing gum that is fortified with Taurine, Guarana and B-vitamins.

In 2011, Fortitech received FS 22000 certification for all of its facilities. Having led the industry with a stringent and comprehensive quality standard that meets and in many cases exceeds industry regulations, this new certification, fully approved by the Global Food Safety Initiative (GFSI), is 100% food safety driven and targets the food manufacturing sector. Currently, Fortitech is one of the first manufacturers to have received global FS 22000 certification across all domestic and international facilities. Fortitech is also committed to helping to decrease the number of people suffering from vitamin and mineral deficiencies in low-income regions of the world; the company’s World Initiative for Nutrition (WIN) works with manufacturers to develop high-quality fortified foods that are available and affordable. This often includes working to meet the specific needs of nongovernmental organizations and governmental and international agencies that are aiming to improve nutrition. With on-demand support from Fortitech’s six facilities worldwide, WIN delivers nutritional solutions that are practical, effective and quality assured (www.fortitech.com)

In the Palm of Their Hand

Carotech (Stand 1058), the largest, and only GMP-certified, palm tocotrienol/ tocopherol producer in the world, will be presenting their latest scientific breakthrough at the show. There is growing scientific evidence of the beneficial effects of a natural full-spectrum palm tocotrienol/tocopherol complex (Tocomin/Tocomin SupraBio) in conferring neuroprotection. Professor K.H. Yuen from the School of Pharmaceutical Sciences, Universiti Sains Malaysia, will be presenting the results of a double-blind, placebo-controlled clinical study that shows that tocotrienols (Tocomin SupraBio, Carotech Inc.) afforded neuroprotection in human volunteers. This is to date the largest human clinical trial on tocotrienols.

The role that full spectrum vitamin E (tocotrienols and tocopherols) plays in supporting cognitive health in the elderly will also be explained by Professor Patrizia Mecocci from the University of Perugia. In a multicentre European study (AddNeuroMed project), Professor Mecocci and her team showed that low plasma levels of all vitamin E forms and increased oxidative/nitrosative markers may be linked to mild cognitive impairment and Alzheimer’s Disease. In another study (Kungsholmen project), the researchers also showed that older Swedish adults who have high plasma levels of all vitamin E forms have a lower rate of Alzheimer’s Disease.

“We are pleased that our research collaborators have made these important scientific discoveries on tocotrienols and are able to share these exciting findings at Vitafoods Europe Conference,” remarks Dr. Sharon Ling, vice president of Carotech UK (www.carotech.net). She added that in addition to brain health, Tocomin SupraBio has been found to reverse non-alcoholic fatty liver condition, promote hair growth and support cardiovascular and skin health. The patented SupraBio system is a self-emulsifying delivery system that guarantees consistent and increased oral absorption of tocotrienols by up to 300% — it is the most bioavailable tocotrienol/tocopherol complex on the market. Carotech will showcase its full range of natural phytonutrients, available in various forms (oil extract, water dispersible powder and compressible beadlets), which cater for dietary supplements, functional food and drink, cosmetic and personal care applications. These include Tocomin, a natural full spectrum palm tocotrienol/tocopherol complex and TocoBev, a water-dispersible, natural full-spectrum palm tocotrienol/tocopherol complex (powder).

www.nutraceuticalmag.com May/June 2012

Sternly Successful

SternVitamin (Stand 1364) focuses on tailor-made micronutrients, co-operating with its customers to develop special vitamin and mineral premixes for fortifying foods and for use in the production of food supplements. At Vitafoods, the company will be demonstrating the benefits of modern production technologies as well as the latest innovative products from its range. One example is fluid-bed drying, which enables the specific enhancement of food product attributes. Food supplements are generally used to compensate for specific nutritional deficits or to ensure a suitable intake of certain nutrients, but in some cases an excessive intake of vitamins and minerals can have a detrimental effect on health. This is why nutritionists are demanding statutory limits to daily consumption and a regulation for the whole European Union is currently in preparation. The manufacturing process used for the products plays a crucial role in enabling suppliers to comply with the future statutory limits; an important aspect of this is the homogenous distribution of active ingredients in the end product.

It must be ensured that the content of the substance is exactly equal in all the tablets or capsules to avoid an overdose or underdose.

In the processing of dry, coarse powders with particle sizes between 50–100 µm, the risk of separation is greatest when individual components differ in respect of their size, density, shape or rate of settling. This is how Dr Sabine Hildebrandt, a food chemist from SternVitamin’s research and development department, puts it: “When powders are made into tablets, the active ingredients may separate during filling or pressing. The result is inaccurate dosing. Particularly with low-dose nutrients such as vitamin B12, vitamin D and biotin, fluctuations in the content of the active ingredient have an adverse effect. To prevent this, the granulation of powdered masses has become an established step in the process of tablet production.” In a granulate, the individual components can no longer separate; the process greatly improves the rheometric properties of the powder and thus the accuracy with which the substance can be dosed. In some cases it is granulation that makes tableting possible at all.

As it permits very gentle processing of the products and a great diversity of applications, fluid-bed technology has become a principal formulation method in the food and pharmaceutical industries. By spraying into liquids during agglomeration, granulation or coating, it is possible to determine the exact physical and application-related attributes of solid products and, by agglomerating the nutrients with the excipients, separation may be reliably prevented during the tableting of, for example, food supplements. Moreover, grain-formulated powder from fluid-bed drying dissolves and disperses much more readily in liquids than fine, spray-dried powder and is also easier to handle. In addition, as a result of their compact form, the granulates are simpler to dose and cause much less dust.

Another point in favour of fluid-bed technology is gentle processing of the products.

With careful control of the drying temperatures, the product is normally only exposed to moderate heat, from 40–70 °C, which minimizes thermal damage; a crucial advantage in the processing of Dr Sabine Hildebrandt heat-sensitive ingredients such as vitamins. To produce granulates for precise dosing, SternVitamin uses the new fluid-bed drying plant at the facility of its sister company, SternMaid, where two dryers with different capacities are available. A small, pilot-scale unit that has been in operation since the beginning of 2012 is used for test runs to develop and optimize new functional ingredients. Production will subsequently be upscaled to a multi-purpose industrial unit for batch or continuous operation which is due to be commissioned in the summer of 2012 (www.sternvitamin.de)

THE BOLD DIFFERENCE i n d e f i n i n g a n d p ro t e c t i n g y o u r b r a n d

Sensient® Pharmaceutical Coating Systems leads the industry in the development and manufacture of innovative coatings and colors for the pharmaceutical and nutraceutical industries. Our patented, regulatory-compliant coatings define and protect brands while delivering application and production-efficiency benefits.

Servicing leading pharmaceutical companies from 35 locations globally, Sensient’s comprehensive range of versatile and novel coating systems offers visual and functional attributes necessary for brand definition, product identification and trademark protection.

Define and protect your brand with superior, high-quality coating systems. Visit sensientpharma.com.

SENSIENT ® PHARMACEUTICAL COATING SYSTEMS A unit of Sensient Technologies Corporation, a leading global manufacturer of colors, flavors and fragrances 2515 N. Jefferson, St. Louis, Missouri 63106 | 800.325.8110 Manufactured in the USA ©2012 Sensient Colors LLC, all rights reserved. The SENSIENT trademark and the Sensient Technologies Corporation logo are owned and registered by Sensient Technologies Corporation. All rights in trademarks are reserved.

P HAR MAC E UT I C AL C OAT IN G S YS T E M S

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High Quality Ingredients

Lonza is one of the world’s leading suppliers to the pharmaceutical, healthcare and life science industries. For the nutrition market, Lonza supplies high quality health ingredients supported by scientific research, regulatory compliance and marketing support. Clear benefits and a broad array of product applications make our products attractive for the dietary supplement, food and beverage, and pharmaceutical industries. At this year’s Vitafoods, Lonza will be presenting its portfolio of branded health ingredients. Carnipure is high quality L-carnitine, a nutrient essential for energy metabolism. Extensive research shows that Carnipure can play a beneficial role in many areas of health, such as sports nutrition, weight management, infant nutrition, male fertility and pregnancy.

Made from naturally occurring microalgae, DHAid is a purely vegetarian source of omega-3 DHA. Health benefits of DHAid include the support of brain development and function, as well as heart and eye health. ResistAid is a natural immune ingredient derived from North American larch trees. It supports both innate and adaptive immune systems as well as gastrointestinal health.

The Memree brand covers a line of products that contain high quality, soy-based phosphatidylserine. Phosphatidylserine is an important structural component of cell membranes and is found in concentrated amounts in brain cells. Products in the Memree line include MemreePS for cognitive health and MemreePlus for cognitive health, stress reduction and exercise recovery applications. Lonza is the leading supplier of vitamin B3 in the form of niacin and niacinamide. Vitamin B3 is an essential vitamin needed for protein, carbohydrate and fat metabolism. At Stand 1435, the company we will be showcasing products containing these ingredients (www.lonzanutrition.com)

Astaxanthin Water Soluble Emulsion

Algatechnologies, Israel (Stand 2052), the leading manufacturer of natural astaxanthin, will launch a 2% natural astaxanthin liquid-emulsion format under the AstaPure brand name. Natural astaxanthin is a lipid-soluble ingredient and can usually used in oil-based formulations. However, owing to its extremely powerful antioxidant properties, there is a high demand in the market for a water-soluble form that can be introduced in “oil-in-water” cosmetic formulations and as an active functional ingredient for beverages. Since the FDA recognized natural astaxanthin as GRAS, there is a growing demand from food and beverage manufacturers seeking water-soluble formulations of the AstaPure brand. The astaxanthin emulsion is produced under patent-protected, ISO- and GMP-certified technology. It is a ready-to-use formulation and can easily be introduced into liquid-filled capsules or any other water-soluble application. The AstaPure line also includes a 10% astaxanthin oleoresin, 2.5% astaxanthin beadlets, 2% astaxanthin vegetarian beadlets, cold-water-dispersible beadlets, 3% astaxanthin powder and 4 mg astaxanthin capsules (supplied in bulk). All products can be used in multiple forms of dietary supplements, cosmeceuticals and functional foods (www.algatech.com)

Shotter Appointed BioFilm Chairman

BioFilm Ltd (www.biofilm.co.uk), Europe’s leading producer of thin film products, has announced the appointment of Peter Shotter as non-executive chairman of the company. Peter has more than 30 years of experience working at a senior level in the Consumer Healthcare and FMCG industry in the UK and Europe. He has been involved in the development of a number of well-known household brands, including Boots and Seven Seas. Recently, he retired from his position as president and CEO of Merck KGaA Consumer Healthcare Division where, during this period, he led the division to substantial growth. Commenting, Peter said: “BioFilm is well placed for growth with its state-of-the-art manufacturing facility and a pipeline of innovative consumer healthcare and wound care products in the Thin Dissolving Film format. I am looking forward to joining the company and helping to commercialize these products and developing the business into a world leader.” BioFilm CEO, Trevor Morgan, said: “Peter’s appointment is an important step in the development of the BioFilm business. His extensive business skills and, in particular, his knowledge and experience of the consumer healthcare markets around the world will prove invaluable as we seek to grow our business internationally. We look forward to working with Peter in pursuit of these goals.”

Improving Iodine Intake from Seaweed

Everyone agrees that iodine is important for human well-being and that a lack of this element in the diet can cause an array of problems, including goitre and hypothyroidism. Moreover, a serious deficiency of iodine during the development of the foetus and the baby may cause irreversible damage to the brain and the central nervous system and, therefore, permanent mental retardation. The European Food and Safety Authority (EFSA) has approved two claims regarding this problem: ID 273, related to iodine and its contribution to normal cognitive and neurological function and ID 274, related to iodine and thyroid function, the production of thyroid hormones and normal energy metabolism. Studies have also reported that adequate iodine intake is necessary to maintain normal cellmediated immunity and suppress certain autoimmune diseases.

The most immediate way for humans to obtain a greater iodine intake is through food, but not all food-bound iodine is bioavailable. To evaluate the bioavailability of AlgeaFood iodine, a test and protocol schedule were developed by the Endocrinology Department of the University of Pisa. A sample of 18 healthy people with no thyroid-related pathologies was randomly given a jar of tablets that, in some cases, contained AlgeaFood tablets and, in others, identical placebo tablets. The results showed a significant increase in iodine in the subjects who took the AlgeaFood tablets compared with the subjects who took the placebo, confirming the bioavailability of AlgeaFood iodine for the human body (www.algea.com). Visit AlgeaFood at Stand 1143.

www.nutraceuticalmag.com May/June 2012

Inspired Innovation

In November 2011, Colloïdes Naturels International and Bio Serae Laboratories merged to become Nexira (Stand 1232). The family run group, founded in 1895, is the world leader in acacia gum (gum Arabic) and a premier supplier of natural nutraceutical ingredients and botanical extracts for the food, nutrition and healthcare industries.

Nexira’s three divisions — Food, Health and Technology — offer global expertise in areas from raw material sourcing and proprietary processing technologies to formulation support. At Vitafoods, this year, Nexira is reinforcing its capabilities in the organic ingredients market by launching a new extract made from organic olives, Oli-Ola, which contains a guaranteed level of hydroxytyrosol, a phytonutrient with strong antioxidant properties that has been shown to reduce the risk of cardiovascular disease by preventing low-density lipoprotein (LDL) oxidation. As hydroxytyrosol has an approved EFSA claim regarding the protection of low-density lipoproteins from oxidative damage and the maintenance of normal blood high-density lipoprotein (HDL) cholesterol levels, using this new olive extract will enable companies to make a cardiovascular health claim, which is a significant marketing advantage for the nutraceutical industry. Nexira’s Health division offers the nutraceutical industry active botanical extracts with multiple health benefits. Their large range of ingredients is guaranteed to the highest standards of quality and purity. In addition, Nexira continues to invest in scientific studies to enrich the backing of its premium ingredients and confirm their natural properties (www.nexira.com)

Flavoured Omega-3 Emulsion

Omega-3 industry leader, Croda (Stand 2038), has revealed that Vitafoods 2012 will be used as the launch platform for its new omega-3 emulsion, Incromega 3mulsion. The delicious 3mulsion is ideal for inclusion in convenient sachets or syrup applications. Just one single-serve sachet or a spoonful of the flavoured emulsion will provide a full omega-3 RDI (250 mg EPA+DHA). “This is a really exciting addition to the Incromega range, bringing to the market a new and innovative way of enabling consumers to get their omega-3 RDI” said Laura Kelly, marketing manager at Croda.

“The market for omega-3 softgel capsules has experienced significant growth in the last few years; however, we recognize that this delivery form does not suit everyone. The flavoured 3mulsion can be included in singleserve sachets and syrups, perfect to be taken as a sweet treat after dinner or to be added to a children’s lunchbox.” Croda’s Incromega lipid range offers highly concentrated EPA and DHA ingredients with proven health benefits. These concentrates provide potent solutions, delivering clear health benefits to the consumer. Incromega marine oils are manufactured using Croda’s industry leading PureMax technology, which minimizes impurities within the oils and guarantees 100% quality testing on every batch, so that customers can feel confident in the quality of the oil they receive (www.croda.com/healthcare)

Solid Dosage Highlights from Aenova

Europe’s leading manufacturer of solid oral dosage forms, the Aenova Group (Stand 1464), is exhibiting two innovative products from its portfolio for the first time at Vitafoods in Geneva: CaloriSorb, a class III drug for weight reduction, and a new technology for manufacturing three-layer-tablets.

CaloriSorb contains a natural polymer that reduces calorie absorption from dietary fats and helps with weight control. The innovative three-layer technology allows several interactive substances to be combined in a single tablet and each layer to be given a different release profile. Alongside these innovations, Aenova is exhibiting its high-quality effervescent products and its range of standard products at Vitafoods. The group, which has a strong presence on the global market, provides technologies to meet a wide range of customer requirements, including the manufacture of soft gelatin capsules, tablets and effervescent products. Aenova also offers its customers a complete portfolio of services, ranging from development, production and analysis through to packaging and logistics (www.aenova.de)

May/June 2012 www.nutraceuticalmag.com

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New Yoghurt Cultures with WOW Effect!

For the third year in a row, global bioscience company Chr. Hansen (Stand 2140) has launched a series of new YoFlex and probiotic nu-trish yoghurt cultures. This time, the focus of Chr. Hansen’s well-oiled innovation machine has been on developing cultures with second-to-none taste and texturing properties, among other things — but not solely — to perform well in low fat milk. More than 20 million tons of yoghurt is consumed every year, corresponding to each person on Earth eating up to 4 kg a year. So far, less than 20% of this volume is low fat yoghurt, even though low fat represents a major part of new product launches during the past 5 years. “If the amount of yoghurt with reduced fat has not grown any faster, it is because the quality has not been good enough. Consumers refuse to accept a poor taste or a thin, watery mouthfeel, no matter how healthy the product may be,” explains Morten Boesen, marketing manager, Fermented Milk Cultures, Chr. Hansen.

“Another predominant market trend, back to nature, has made it even more complicated for yoghurt producers. The natural trend is driving product development towards using an absolute minimum of ingredients, which, for yoghurt, means milk, cultures and possibly fruit — that is, no stabilizers, thickeners and flavours added to compensate for the lack of fat. So far, high quality yoghurt has been contradictory to healthy and fat reduced — but not anymore! Chr. Hansen’s new cultures can do the trick and unite them,” promises Boesen. The new portfolio of seven cultures, three of them with the well-documented BB-12 probiotic strain for improved gut and immune health, enables dairies worldwide to deliver on all three parameters at the same time: exquisite taste, healthy and clean label. “The Creamy and Premium cultures developed during the past 2 years provide the creaminess, texture and good taste normally provided by fat and additives, so there is no longer any excuse for not producing delicious, clean, natural yoghurt with optimal nutritional properties,” Boesen says (www.chr-hansen.com)

New Nutrient Platforms from DSM

help the mind stay alert, whereas ‘Relax your mind’ features nutraceuticals such

Global supplier of health and nutrition ingredients, DSM (Stand 2030), is

as chamomile and lemon balm that help to calm the mind and prepare the body for

launching three Health Benefit Solutions and the dietary enzyme Tolerase L at

sleep.

this year’s Vitafoods. Designed to meet the ever-evolving requirements of the

To help consumers get the optimal amount of nutrients from food, beverage

modern consumer, these new platforms feature a range of vitamins, minerals and

and dietary supplements, DSM is also introducing Tolerase L at this year’s show.

functional ingredients for three growing areas of consumer interest: relaxation

Tolerase L is an acid lactase that is active at low pH levels, making it particularly

and sleep, improved mental energy and wakefulness, and nutrients that cater

effective at digesting lactose in the stomach and therefore ideal for use in dietary

to the specific nutritional requirements of vegetarians. The key ingredient in the

supplements as a digestive aid. Tolerase L helps to eliminate lactose intolerance

vegetarian platform is life’sDHA, a form of DHA derived from algae. life’sDHA has

discomfort and increase the quality of life of consumers with lactose intolerance or

supported the nutritional needs of more than 60 million babies and is now included

malabsorption. Back by popular demand, visitors will be able to sample the Health

in more than 500 food and beverage products worldwide. Essential for brain, eye

Benefit Solutions, including Energize your mind, Relax your mind and Essentials for

and heart health, this omega-3 is often lacking in vegetarian diets as the primary

vegetarians through a range of tasty samples. To find out more about DSM’s Health

food source is oily fish such as salmon and tuna. ‘Energize your mind’ features a

Benefits solutions, in-depth consumer insights and extensive market knowledge,

number of ingredients, including gingko biloba, ginseng and coenzyme Q10 that

visit our brand new website (www.dsm.com/human-nutrition)

www.nutraceuticalmag.com May/June 2012

Imagine having a new application for your next blockbuster supplement.

Sounding out the unmet needs of tomorrow’s nutrition is essential for a successful business. We want to discover and meet these needs—open minded, with deep insight and in a constant, fruitful dialog with you.

We are looking forward to your feedback at www.newtrition.basf.com

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NBTA preview

in association with

NBTA II: Going for Gold The contestants in this competition won’t be focusing on bronze or silver medals, the spotlight of anticipation will most certainly be trained on the gold envelopes that, when opened — after several rounds of intense judging by a distinguished panel of experts — will reveal the names of the worthy winners of the second annual Nutraceutical Business & Technology Awards.

A

nd we’re back! The Olympic Games may well be coming to London this summer, but another equally hard fought competition — and just as international — will come to a head on 23 May during Vitafoods Europe when the second Nutraceutical Business & Technology Awards reaches its climax. And unlike platinum sponsor Aker BioMarine, we may not be able to offer you the chance to meet the famous Olympic biathlon gold medalist, Ole Einar Bjørndalen — who claims to use the company’s Superba Krill Oil supplement to boost his omega-3 levels — we can certainly provide a five-star gala dinner evening of entertainment and innovation. Henrik Traaholt, business director at Aker BioMarine, described the NBTA as a professional gathering place for the industry’s high-level leadership and one of Europe’s most important events for natural ingredient suppliers. As a showcase for innovation and the new home of credible awards that recognize success in the functional food and drink sector, it’s the obvious place for Aker BioMarine, a market leader in krill harvesting and processing, to have a significant presence and further establish itself as “the shaper of the biomarine industry.” As I write this, the judging process is still under way; the shortlist has been announced and the final round of assessment, analysis and comparison is being done. The tension is almost palpable.

www.nutraceuticalmag.com May/June 2012

Last year, when we launched the event in association with Vitafoods Europe, we didn’t know what to expect, we didn’t know what the reaction would be. As it turned out, all our fears were allayed; as Miranda Docherty, Event Director, said at the time: “With more than 250 industry professionals in attendance, an impressive list of finalists and award winners, it was hard to believe that this event was the first of its kind.” I remember the fierce competition and the exceptional standard of entries, and we were all delighted with the number and quality of the submissions.

The reaction and buy-in from the industry was impressive and more than we could have hoped for. But that was then, and this is now. Can we pull off the “difficult second album” and do it all over again? Know what? I think we can!

Thomas Jahn, marketing manager at Fertin Pharma A/S, one of this year’s gold sponsors, noted: “After the successful launch of the NBTA event last year, we were very keen to support the event once again. We see the event as an excellent opportunity to put ourselves in touch with the beating heart of the nutraceutical industry. As Fertin is fairly new to the nutraceutical industry, we are interested in building awareness around our company and chewing gum technology … and the NBTA event provides an ideal setting for this.” So far, I am thrilled that so many industry players

NBTA preview

NBTA in a Nutshell

Debuting in 2011, in partnership with Vitafoods Europe, the NBT Awards recognize excellence in R&D, marketing, business and technology within the nutraceutical and functional food industries. Its mission is to deliver a set of benchmarks that provide a pan-European/global audience of nutraceutical professionals with the opportunity to recognize significant developments in quality of service, health management, research and development, and relationship management, and will also provide a recognized and tangible reward for the successful companies. Offering both a professional and social platform, NBTA provides an opportunity to gain maximum exposure from professionals in the fields of functional foods, cosmeceuticals and nutraceutical ingredients.

have decided to have another go at getting their hands on one or more of the awards. Many of the companies that competed last year are back to take another swing. And, clearly, word has spread; a whole brigade of new organizations has heard the call and submitted nominations. Early on, it became apparent that I was going to have to add extra people to the judging panel: the entries were stacking up fast. As ever, I am extremely grateful to the judges for generously donating so much of their time and expertise. It has been a challenging and fascinating task to get to this point, and I’m very much looking forward to the winners being announced on the night.

In addition, I think, perhaps, the bar has been raised. The standard and volume of nominations received has made it an incredibly difficult decision for the judging panel. The judges have asked more questions about the entries, some of the highest scores have been given — and some of the lowest — and it has been an almost impossible task to separate the frontrunners in several of the categories. It has become the norm, not the exception, to involve a tiebreaker judge to help to make a final decision. Sincerely then, I do congratulate the finalists, you’ve already done incredibly well.

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Europe. Ewa Hudson commented: “It is an honour to moderate the NBT Roundtable and I would like to thank Dr Kevin Robinson, Via Connect and Via Media UK Ltd for inviting me to take on this role again. I hope the NBT Roundtable will be the most interesting and spoken about event of the year within the nutrition space.”

Chris Lee, Portfolio Director at Vitafoods, recently commented: “Innovation is the lifeblood of any organization; it helps us to discover new ways of working, improved products or technologies and, in a business context, to stay ahead of the competition.” I couldn’t agree more and would reiterate that the NBTA is the ultimate platform upon which Vitafoods attendees, sponsors and industry professionals can network and celebrate new and significant developments with those companies and individuals that have successfully demonstrated their outstanding contributions to the industry. In closing, as part of the organizing team, I would, once again on their behalf, like to extend our sincere thanks to the 20-plus sponsors who are supporting this year’s event and highlight headline sponsor, Naturex, platinum sponsor, Aker BioMarine, gold sponsors, Fertin Pharma and Biotivia, and silver sponsors, Croda, Horphag, Stratum Nutrition, OmniActive Health Technologies and Biocell Technology. Biotivia’s James Betz added: “The decision to become a gold sponsor was an obvious one for our management. To us at Biotivia, the contribution that NBTA makes to facilitating the fundamental communication process amongst the disparate members of our industry is unique and invaluable. I am not aware of any other forum or event that brings together the core staffs of so many interrelated companies in such a productive and enjoyable setting.” We are also very grateful to BASF for sponsoring the champagne reception. It’s going to be a fantastic evening and I very much look forward to seeing you all there.

NBT Business Roundtable

Also returning to the schedule is the NBT Business Roundtable, sponsored and endorsed by Ninapharm. We are delighted to welcome back Euromonitor’s Head of Health and Wellness Research, Ewa Hudson, as moderator as, on the agenda this year, we take a slightly different tack.

With the functional food sector undergoing unprecedented change and the spotlight being placed on quality, purity and sustainability, the debate will focus on “Nutraceuticals: An Industry in Transition.” We will be asking: What does the nutra industry need to do to remain viable and keep the pharma wolf from its doors? Populating the top table, we are honoured to be able to include • Dr Alfred Jenssen, Sanki Mayor Innovation Center, Tokyo, Japan • Dr Emiri Nishi, Ninapharm, Japan • Dr Paul Berryman, Chief Executive at Leatherhead Food Research, UK • George Pontiakos, President/CEO of BI Nutraceuticals, USA • Adam Ismail, Executive Director, GOED, USA • George Paraskevakos, President, International Probiotics Association, Switzerland.

The topics up for discussion consist of purity and quality (dry labbing and botanical adulteration), sustainability (global sourcing issues and the facts and fiction surrounding marine sustainability), IP and litigation (Is the nutraceutical industry already getting litigious?) and some of the challenges that the functional food sector is presenting to Big Pharma: the accelerated absorption of antioxidants from fish-based omega-3s, antiageing and inflammation reduction, and the legal status of probiotic health claims in

When and Where?

Wednesday 23 May The Starling Geneva Hotel and Conference Centre Geneva, Switzerland (www.shgeneva.com) Champagne Reception: 7:00 pm Gala Dinner: 8:15 pm Awards Presentation: 9:30 pm Carriages: 11:30 pm Dress Code: Evening/Business

22

NBTA sponsors

NBTA SPONSORS Headline Sponsor

Naturex (www.naturex.com) Naturex manufactures natural speciality ingredients for the Nutrition & Health, Food & Beverage and Personal Care industries. Headquartered in France, Naturex employs over 1200 people and has 16 production units located in Europe (France, Italy, Spain, Switzerland, Poland and England), the United States (New Jersey and California), Brazil, Australia, Morocco and India. In addition, the group has several sales offices worldwide.

PLATINUM Sponsor Aker BioMarine (www.superbakrill.com) Aker BioMarine is a sustainable biotech company and supplier of Superba Krill Oil. 100% pure krill with unique phospholipid EPA and DHA Omega-3s and the naturally occurring antioxidant astaxanthin, Superba has clinically proven efficiency. Superba is easy to swallow, easy to digest, and easily absorbed into the body’s cells. Aker is the only krill fishery to earn MSC Certification for sustainable harvesting and only Superba Krill products have 100% traceability from sea to shelf.

GOLD Sponsor

GOLD Sponsor

GOLD Sponsor

Lab Dom (www.labdom.com)

Fertin (www.fertin.com)

Biotivia (www.biotivia.co.uk)

With state-of-the-art laboratories and highly professional medical staff based in Switzerland, as well as the European Union and Asia-Pacific, Lab Dom (Suisse) Inc. is committed to innovative research and development in the rapidly expanding fields of bio-regenerative medicine and anti-aging cellular therapy fields.

Located in Denmark, Fertin Pharma A/S is a full service manufacturer of medicated chewing gum. With a strong commitment to quality and innovation coupled with almost 100 years experience with chewing gum, through its’ affiliated companies, Fertin is amongst the world’s preferred suppliers when it comes to medicated chewing gum.

Biotivia Bioceuticals bridges the health and wellness gap between conventional dietary supplements and pharmaceuticals. Biotivia’s relentless adherence to a strict evidence based product development strategy synergized by its extensive knowledge of plant derived therapies, fueled by intelligent innovation, has established the company in a class of its own.

www.nutraceuticalmag.com May/June 2012

23

NBTA sponsors

champagne reception sponsor

SILVER Sponsors

BASF Group (www.human-nutrition.basf.com)

Horphag Research (www.pycnogenol.com) Horphag Research is the exclusive supplier of Pycnogenol®, a natural extract of French maritime pine bark. Pycnogenol® is a powerful antioxidant, selectively binds to collagen and elastin, is a natural anti-inflammatory, and aids in the

BASF and Cognis – which is now part of the BASF Group –

production of endothelial nitric oxide

presented their latest Newtrition™ concepts and finished products

which helps to vasodilate blood

at Vitafoods, in Geneva, 10-12 May 2011. The newly-formed BASF

vessels. Among others, applications

Human Nutrition Group combines the two complementary nutrition

are cardiovascular health, skin care, eye health, joint health, among

businesses, offering customers the benefits of an extended product

others. Over 280 scientific publications and 90 clinical trials have

range, enhanced market strengths and expertise, technical skills and

confirmed Pycnogenol’s safety, quality and efficacy. ISO, GMP

resources.

certified, and GRAS-approved.

SILVER SponsorS

BioCell Technology, LLC (www.biocelltechnology.com)

Croda Health Care (www.croda.com)

BioCell Technology,

Superior quality makes

LLC, founded in 1997,

Croda Health Care a supplier

is in the business of

of choice when looking for omega 3 ingredients to add value to your nutritional or food offering.

Our IncromegaTM lipids are a range of omega 3 concentrates with high levels of EPA and DHA that offer potent solutions with recognised health benefits.

NBT Awards Finalists 2012 Best New Plant/Process/Technology • Atlas Filtri Engineering • Capsugel Inc. • 3i Nature SAS • IRB Tec Most Effective Marketing Campaign • Kaneka Pharma Europe NV • Lab Dom (Suisse) Inc. • Naturex Outstanding Application in Health Management • Biothera • Fertin Pharma AS • NourishLife, LLC • Horphag Research • Kaneka Pharma Europe NV Best New Finished Product • Aker Biomarine • Naturex • Barry Callebaut • Lallemand SAS • Herbal T SAS

researching, developing, branding, and distributing novel dietary ingredients which are supported by science to improve quality of life. BioCell Technology’s branded ingredients which include patented BioCell Collagen, i-Sabi, and EstraFlex CMO, are available under licensing to marketers and manufacturers of finished products.

Stratum Nutrition® (www.stratumnutrition.com) Stratum Nutrition® is Empowering Product Innovation with specialty and functional ingredients for foods and supplements. Visit Vitafoods stand #1189 to learn about our newest ingredients: BLIS K12™ and BLIS M18™ - oral probiotics with science evaluating their effects on upper respiratory health, immune support, and the health of teeth and gums.

Most Improved Product Safety and Quality • Capsugel Inc. • Horphag Research • Trace Minerals Research Most Effective Strategic Product Development • Horphag Research • Kaneka Pharma Europe NV • Naturex Environmental Excellence • Croda • IRB Tech • Seagreens Ltd • Algea AS • OmniActive Health Technologies Most Innovative Ingredient • Kitozyme • Biocell Technology • Kaneka Pharma Europe NV • Lab Dom (Suisse) Inc. • Naturex Innovation in Personal Care • Indena SpA • Sabinsa Europe GmbH • Provital Group • IRB

OmniActive Health Technologies (www.omniactives.com) OmniActive Health Technologies provides naturally sourced ingredients for healthcare, foods and personal care products. Known for technological innovation, OmniActive enhances the nutritional benefits of ingredients through patented and patent pending technologies. A recipient of multiple global awards, OmniActive’s breakthrough technologies enhance the body’s ability to absorb and utilize health promoting nutrients.

May/June 2012 www.nutraceuticalmag.com

24

NBTA sponsors

additional sponsors Sabinsa Europe GmBH (www.sabinsaeurope.com)

Genosa ID (www.genosa.com) Genosa ID is the global leading producer of an olive fruit extract

Sabinsa Europe GmbH represents

with a high concentration in 100%

Sabinsa’s marketing and sales

natural hydroxytyrosol (Hytolive®).

platform as well as the service for all

Hydroxytytrosol is the major and most

of our customers across Europe. We

active ortho-diphenol present in virgin olive oil and olive fruit. It is a

combine the advantages of Sabinsa’s

very simple, stable, active and bio-available molecule, manufactured

unique product portfolio with the local

under an internationally patented technology characterized by the

logistic requirements and provide an outstanding service to all of our

sole use of physical and mechanical processes, without solvents, the

European customers. Our Mission is to provide high level customer

only 100% natural product.

service, technical back up, formulation development services and the introduction of new patented products for the diverse needs of

Ninapharm (www.ninapharm.com)

the manufacturers in the industry. Sabinsa Europe is the independent

Founded in Annecy (French Alps) in

marketing arm of Sabinsa Corporation.

1993, NINAPHARM’s core business is

LycoRed (www.lycored.com)

focus on the development of antioxidant actives for cosmetics, nutraceutical and

LycoRed, manufacturer of unique

pharmaceutical fields. The uniqueness

natural tomato complex containing

of the laboratory comes from the combination of controlling the

high levels of lycopene and

production of its antioxidants raw materials and an advanced

phytosterols. Recent evidence shows

chemistry. This allows the company to offer solutions from bio-actives

its beneficial effect on cardiovascular health as well as blood pressure

solubility and in-vivo absorption using its in-house Nanotechnology

level that is already within the normal range. LycoRed manufacturer

platform, to its medicalized food concepts. With a Blue ocean

also, natural carotenoids, microencapsulated vitamins, minerals

strategy, Ninapharm supported the development of several world

and other special ingredients in addition to premixes for the Food &

success products, from top slimming formula in Europe, to top

Beverage industry.

sales anti-aging cosmetics in Japan, making Ninapharm famous as

Kitoyzme (www.kitozyme.com)

Innovator’s supplier.

KitoZyme Headquartered in

3i nature (www.3inature.com)

Liege, Belgium is a manufacturer

3i nature is an industrial company

of leading-edge functional

specialized in the formulation,

biopolymers and a full-service

development and production of high

provider of medical device products. More precisely, KitoZyme

quality nutraceuticals for 25 years.

develops and produces - chitosan (and derivatives), chitin-glucan

Our i, 2i, 3i offers cover the nutraceutical market from stabilized

and beta-glucan, exclusively extracted from renewable, non-GMO

solutions available on the market over 12 weeks to specific formula,

and vegetable sources.” With its highly-skilled team, KitoZyme has

generic health claim and clinical health claim. Our pharma offer and

developed expertise in product development, quality management,

GMP plant extend our vegetal expertise to pharmaceutical status.

clinical development, regulatory affairs, marketing and distribution.

Capsugel (www.capsugel.com)

Herbal T (www.herbalt.net)

From assisting our customers

Herbal T is an industrial company

with formulation challenges

specialized in the production of

to helping them bring innovative new products to market faster,

HTVE® - High Technology Vegetal

the world-class people at Capsugel provide a unique combination

Extracts – for the food & beverage markets. Create with us. Herbal

of scientific, technological and global market expertise, delivering

T has a strong expertise on teas, spices & herbs and intermediate

high-quality capsules and services at every step of the dosage form

food product markets. He is your partner to develop and strength the

development process.

innovative nature of your products.

Solbar (www.solbar.com)

IRB (www.irbtech.com)

Solbar is a global leader in specialty

IRB is an Italian green biotech company

soy proteins and soy isoflavones.

focused on research, development and

This February Solbar became a part

manufacturing innovative plant active

of CHS a leading farmer-owned

ingredients from plant cell cultures for

American cooperative. Solbar will be presenting a newly developed

nutritional applications. Thanks to its optimized

line of soy-protein isolates for the weight-management market.

and eco-sustainable HTNTM platform, IRB

The new line includes innovative textured products based on two

industrially produces the unique biotech plant

fundamental principles: taste and health.

extracts approved in Europe as food supplement ingredients.

www.nutraceuticalmag.com May/June 2012

Olive extract with approved health claim CreAgri Inc. (www.creagri.com) CreAgri Inc., a California based Nutraceutical company, is the inventor and developer of HIDROX®, the world’s first formulation of organic olive polyphenols rich in Hydroxytyrosol. Its mission is to promote health and wellness creating superior natural products striving to strike a Creative Balance between Nature and Technology®. CreAgri develops science-based processes that are eco-friendly and compatible with sustainable agricultural practices. Clinically proven in inflammation driven conditions, Hidrox® is still the he only formulation of Hydroxytyrosol to be

Guaranteed hydroxytyrosol content Oli-Ola™ is an olive extract with guaranteed hydroxytyrosol content.

GRAS, Kosher, Halal and CCOF Organic Certified.

Algea (www.algea.net) Algea was founded in 1937 thanks to a strong intuition

Protection of LDL cholesterol EFSA approved health claim for cardiovsacular health.

about the potential of using seaweed for nutrition. This is how a pioneering activity began at the extreme northern latitudes of Norway and just beyond the boundaries of the Arctic Circle, where the ecosystem is still intact and uncontaminated by human presence. Here, for over

Sustainable olive extract Oli-Ola™ is made from organic olives and is solvent-free.

70 years, Algea has been collecting and processing seaweed which is unique in the world, using a process that preserves the incredibly characteristics of the seaweed and is of minimum environmental impact. This is how Algea skilfully transforms the seaweed into an ingredient for products for human nutrition, animal nutrition, cosmetics and fertilization.

Kaneka Pharma Europe N.V. (www.kaneka.co.jp) KANEKA Pharma Europe (subsidiary of Kaneka Corporation - Japan) is the leading manufacturer of high quality natural safe and innovative health ingredients.

As experts in Coenzyme Q10 made via a unique yeast fermentation process (KANEKA Q10TM), KANEKA has developed other active ingredients: • KANEKA QHTM Ubiquinol: the “New generation of Bioactive CoQ10“ • GLAVONOIDTM: the NOVEL FOOD approved ingredient for weight management • KANEKA NAGTM: the bioactive form of glucosamine to support joint and skin health

www.nexira.com Tel.: (+33) 232 83 18 18 info@nexira.com

26

GOED report

How Much EPA and DHA is Enough?

T he Agency for Healthcare Research and Quality (AHRQ) in the United States has recently published a review and metaanalysis of evidence from prospective cohorts and randomized controlled trials on the relationship of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake to cardiovascular or allcause mortality. According to the authors, the maximal positive effect of EPA and DHA for mortality risk reduction appears to plateau at a mean daily intake of 200 mg, with no evidence that higher intakes are accompanied by a significant change in risk. Although GOED, like many in the industry, would have liked to see recognition of a greater intake than 200 mg/day, it is in line with the 2009 European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA) Scientific Opinion on Dietary Reference Values for fats, not to mention a 2011 British Journal of Nutrition publication on a meta-analysis funded by GOED members. GOED considers the report to be a positive development in the US. In 2009, the NDA proposed setting an adequate intake (AI) for adults of 250 mg/day for EPA and DHA, based on considerations of cardiovascular health. The panel relied heavily on a meta-analysis that demonstrated a significant threshold effect at intakes of 250 mg/ day for cardiovascular mortality. At the time, the panel considered the meta-analysis to be “the best available estimate to establish an AI for DHA and EPA on the basis of CVD risk in healthy populations, for which DRVs are meant.” During the public consultation on the Panel’s Draft Opinion on Dietary Reference Values for fats, GOED provided significant comments, including some specific to dose and associated cardiovascular benefits. In general, we encouraged the panel to consider 250 mg/day a minimal, rather than optimal, intake.

GOED recognized a positive correlation between realized benefits and intake with increasing doses towards 250 mg/day. However, owing to uncertainties inherent in the analysis, the benefits gained above 250 mg/day are not as clear and it could only be concluded that maximum efficacy lies above 250 mg/day, but closer to 500 mg/day when looking at CVD risk. Although the NDA did not change its opinion and the level remained at 250 mg/day, GOED still considered this to be a win: some of the population will not realize the maximum benefits at 250 mg/day — but there are individuals who will.

The findings from the AHRQ report are in line with a meta-analysis, funded by GOED members, in individuals with no reported coronary heart disease (CHD). The two meta-analyses followed similar approaches and reached similar conclusions. The main difference was in the studies included and, interestingly, the different inclusion/ exclusion criteria did not significantly alter the conclusions. Americans and those conducting business in the US should keep in mind that this report provides recognition from a government agency (AHRQ) that is relied upon by both the Institute of Medicine (IOM) and the Food and Drug Administration (FDA) to conduct many of its scientific reviews.

Of particular interest is a discussion on Dietary Reference Intakes (DRIs). It’s worth noting that after the IOM called a DRI committee to undertake a review of the evidence and potential revision of the values for calcium and vitamin D, the AHRQ was commissioned to provide a systematic review of the scientific literature for use by the committee.

www.nutraceuticalmag.com May/June 2012

Although the AHRQ review could have been executed for any number of reasons, it’s difficult not to imagine that it has something to do with a pending DRI review for EPA and DHA. Recommended intakes are important because they allow for nutrient content claims that help consumers to know whether a product contains a significant level of a particular nutrient.

In the US, there is currently a qualified health claim concerning the consumption of EPA and DHA omega-3 fatty acids and a reduced risk of coronary heart disease. Although GOED does not believe that this claim accurately reflects the current state of the science, given the substantiation requirements necessary to demonstrate “significant scientific agreement” for an authorized health claim, it’s not clear how much the AHRQ report will help. Despite the FDA wanting to see data in healthy individuals, the agency gives the most weight to intervention trials. The AHRQ report contains data in healthy individuals but the studies are prospective.

However, it is important to note that greater EPA and DHA consumption may offer benefits beyond the reduction of mortality; EFSA has published scientific opinions affirming that high-level consumption (>2000 mg/day) can help to maintain normal triglyceride and blood pressure levels. In addition, its opinion on DRVs for fats included a recommendation that pregnant and nursing women consume an additional 200 mg/day of DHA above the EPA and DHA DRV for adults of 250 mg/day. As omega-3s affect multiple systems in the body, it is always important to remember the bigger picture!

To conclude, although the 200 mg/day of EPA and DHA cited by the AHRQ report may be short of what the industry would like to see as a daily intake recommendation, it is in line with the NDA and the metaanalysis funded by GOED members in terms of mortality risk. GOED remains hopeful that the AHRQ report will advance the efforts to obtain an actual recommended level and an authorized health claim.

References

A full list of references to support the research and statements made in this column is available from the authors.

For more information

Adam Ismail, Executive Director and Harry Rice, VP, Regulatory and Scientific Affairs Global Organization for EPA and DHA Omega-3s (GOED) 1075 East Hollywood Avenue Salt Lake City, Utah 84105, USA Tel. +1 801 746 1413 www.goedomega3.com

Crédit photo : © JupiterImages

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28

executive profile

Operating in the Wriggling Room

Continuing to look at the convergence between the pharmaceutical and nutraceutical industries, Dr Kevin Robinson recently caught up with Dr Atle Skattebol, chief medical officer, EPAX AS, to discuss some of the issues that are bringing the sectors together … and keeping them apart.

NBT: How and when do R&D, product development and marketing converge in building a brand, whether it’s pharma, nutra or personal care?

AS: In today’s market, I think that any company that does not have an integrated team in place, wherein all these aspects are taken into consideration from the get go, are doomed to fail. It has to be a multifunctional team approach.

its constituents against improper use. The process of a physician prescribing and a pharmacist dispensing effectively maintains this safeguard. Clearly, we do see a trend that when a drug has been on the market for a very long time and has a very good safety profile, then the lowest dose is made available for general sale to the public. I’m sure that this is a trend that will increase in the years to come.

NBT: Marketing must change and consumer education is critical. Is it right and proper for the healthcare industry to sell directly to consumers? Will the traditional doctor-referral approach be a thing of the past, benefiting CPG companies who have more experience?

AS: Yes, marketing must and will change to follow the trends that at any given point exist in the community in which the marketing is being done. This varies to a great deal, depending on where you look in the world.

One general trend, however, is that the consumer is getting more educated. Be it through the Internet, newspapers or magazine articles, the consumer now knows more and more about diseases and what is important for maintaining general health. The healthcare industry is an extremely diversified business ranging from companies that produce purely nutritional supplements to those producing only pharmaceuticals. I think it is very appropriate for the healthcare industry to sell directly to consumers when it comes to supplements aimed at maintaining health and well-being. I think we need to be a little more careful when it comes to pharmaceuticals.

To my knowledge, only two countries in the developed world allow direct-to-consumer advertising of pharmaceuticals, the US and New Zealand. Neither of these, however, allows direct sales to the consumer. This needs to be done through the traditional prescription/pharmacy route. I think this route will continue to be the mainstay with regards to the treatment of disease. We need to remember that no drug is without sideeffects and society feels a need to safeguard

NBT: With Big Nutra already experiencing a fierce patent infringement suit concerning an omega-3 formulation, is the industry already following in the footsteps of the highly litigious pharmaceutical sector? Are there lessons to be learnt and preventive steps to be taken?

AS: IP is core to any business that has invested money into research and product development. In many senses, it is a relatively new area for Big Nutra and a reflection of the fact that Big Pharma and Big Nutra are converging to a great extent. For Big Pharma, IP has been alpha-omega since the beginning; but, considering that most new drugs are synthetic compounds, it is also easy to get good patent protection on them.

For functional foods, this is not the case; the compounds are, for the most part, naturally occurring and hence non-patentable as such.

One then needs to look into formulation and use patents. These are traditionally much weaker patents that the composition of matter patents that are usually seen in Big Pharma. Unfortunately, I think Big Nutra is headed down the same path as Big Pharma.

The protection of IP through litigation seems to be a prevailing pattern as long as big money is at stake. I think that the only thing the nutraceutical sector can learn from this is to always plan ahead and to patent every interesting find.

www.nutraceuticalmag.com May/June 2012

NBT: As the nutra market grows, food companies are more likely to see near-term success than drug-oriented ones. Are clinical trials and analytical science the only benefits that Big Pharma can bring to the table? And

will that be enough for market success?

AS: I actually disagree with the first statement.

With the growing nutraceutical market also comes a greater societal demand for evidence. This is where the nutra and pharma sector will be converging more and more in the years to come. We already see the contours of stricter and stricter codes for marketing and the types of claims that can be put forward in the nutra sector. I don’t think that the pure marketing muscle of the big food companies is enough in this instance. The approach that Big Pharma has traditionally employed — the scientific documentation of claims — will prevail.

NBT: The Advertising Standards Authority (ASA) has set up a ‘common pool’ of experts to specifically analyse cosmetic advertisements for false or misleading claims, following a string of adjudications made recently. With nutra meeting personal care and pharma meeting nutra, will this be a cross-industry problem and how can it be regulated?

AS: We need to remember that in the nutra and pharma world, we are dealing with the health of consumers. This, in my opinion, is no light matter. The market should therefore have no room for participants that do not take this seriously. Health claims should be documented. There are very clear rules regarding how pharmaceuticals are documented and marketed. We should work towards having the same type of rules, albeit in a lighter version, in the nutra sector. This work is already under way, but there is still enough “wriggling” room that companies that do not take this seriously still are able to operate.

For more information Atle Skattebol Chief Medical Officer EPAX AS Tel. +47 7013 5960 atle.skattebol@epax.com www.epax.com

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30

opinion

Constant Industry Transparency: The Time is Now The phytochemical industry needs to ‘activate itself ’ by instituting ethical self-regulation before it becomes so sick that it resorts to consuming its rival allopathic medicines. It’s time for the industry to grow up, own up and take charge of itself, if it is going to survive. Although challenges abound and complexities rule, there is an irrefutable truth that needs to reign.

T

he advent of the Internet and, in particular, social media has opened a global minefield of easily accessed information. Although this is not the subject of this article, it is pertinent because consumers are more aware than ever about what is available to them and the efficacy and ethical state of products. The impact of the fact they are willing to share their opinions with everyone in their network can determine the business success of a product or service … and it is this fact that needs to be considered most when marketing new products.

Regarding the nutraceutical and functional foods industries, this savvy purchasing culture demands products that work and labels that are clear and which detail exactly what the product contains and what it does.

Consumers are also wise to marketing claims and often take them with more than just a healthy pinch of salt.

Their indifference or their dismissal of a product is difficult to win back.

People increasingly rely on personal recommendation from peer groups and consumer activists. They trust word of mouth — far more than marketing speak — to influence their health and lifestyle choices.

www.nutraceuticalmag.com May/June 2012

Entire television programmes (such as Dr Oz in the USA) and social media campaigns are now blatantly exposing how so called “health” supplements don’t work. A recent university led study conducted in South Africa shows for example that all omega-3 fatty acid supplements have been measured and found to be wanting. The result: entire ranges of products removed from the shelves; more prevalent consumer dissatisfaction and distrust. This should send a warning to the entire alternative health industry who, in the main, have been used to selling hundreds of bottles of ineffective products based on hype.

So why do these products more often than not fail to work or not match up to consumer expectation? And why is the industry culpable in perpetuating this state of affairs? The answers are complex and mostly unpalatable but they need to be faced — or digested — before this multibillion dollar industry does irreparable harms to itself and others.

Historically, marketing and label claims have been allowed to state benefits of almost magical proportion. Who wouldn’t want to improve their mental or sexual prowess, look like a supermodel, shape up like Mr Universe or lose two dress sizes in a month — simply by consuming a pill or drinking a potion (shake or smoothie)? Science has proved that natural products do work, if consumed in the right quantities, but outlandish claims and unethical practices are and will damage the industry in the long-term. We can’t just blame the marketing department though. We also need to look to the source — the suppliers of the ‘active’ ingredients — and the lack of sufficient quantity and quality of the ‘actives’ themselves.

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32

opinion

Consumers are beginning to read labels carefully. They are beginning to take responsibility for their health decisions, understanding perhaps for the first time that the need for the right levels of ‘active’ ingredients (phytochemicals) are required to have the desired effect. And it is here that the real danger lies. Can you imagine if the pharmaceutical industry included too little of the specific ‘curing’ chemical in their products, rendering said product useless, causing death (worst case scenario)? The outrage and the impact would be immediate.

So, when is the phytochemical industry (from which the pharmaceutical industry derives its allopathic synthesized molecules) going to wake up to the need to supply high efficacy ‘actives’ according to clinically proven science?

Grist for the Mill By way of example, when analysed by a leading South African university, two capsules of DCD Hoodia gordonii extract equating to 800 mg (containjng 12 mg of P57, the scientifically researched and quantified active ingredient) were equal to 164 capsules of a so called high efficacy Hoodia extract content proclaimed by a recognized retail brand in South Africa. In another instance, the USDA showed that one cup of green tea needs to contain 1253 ORACS/100 g to be effective.

But the Oxidative Stress laboratory at Cape Peninsular University of Technology (CPUT) tested a number of green teas available in South Africa and these values varied from 250 to 800 ORACS per 100 g. Tea companies only do a flavour and nose (organoleptic) test on each batch to make sure the tea tastes the same; but, at no time do they ever test or worry about the active that made us desire to drink that particular tea in the first place. I know that I am one of many consumers who have recently noticed how tea seems to be weaker these days.

There is either a genuine lack of knowledge on the part of contract manufacturers in terms of the actives and the science behind them or, more worryingly, a laissez-faire approach in general to supplying and accepting substandard extracts, which is now prompting governments around the world to get their acts together. Millions of dollars are spent on scientific research to determine a plant’s make up, what the ‘active’ ingredients might be and how much is needed to be effective. Yet, when it comes down to it, the right level of ‘active’ is frequently not included. This results from many reasons, including the following:

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• the manufacturer buys the cheapest extract they can find (no active or very little active present) just to claim the product contains it • the initial extraction process denatures the ‘actives’ by the use of harmful heat, oxidation and/or chemicals, whereby only a fraction of the scientifically proven dosage is extracted and used • lack of standardization: the scientifically quantified clinical dosage that needs to be the same in every batch isn’t, because the science is usually conducted on wild plants; when commercialized, it is unsustainable, resulting in growing and using cultivated material wherein the active content is vastly reduced • science also determines that a certain level of ‘active’ is present in the plant, such that X equals a certain amount needed to obtain Y effect, deriving a specific ratio; with the use of cultivated plants, however, that ratio is no longer relevant and therefore the ‘actual active’ content is different, which should be mentioned on the certificate of analysis (COA) … but often isn’t.

For example, if the ratio is 100:1 (100 kg of product used to produce 1 kg of extract), when asked what the ‘active’ content is, certain extract suppliers are often unable to quantify. In fact, in some instances when we have queried the COAs, we have been given “detectable” as an answer. What does that mean? From this, I can only determine that the industry itself does not know the right questions to ask of suppliers, as the COAs are often incorrect and frequently inflated and don’t appear to be challenged.

How is it possible to manufacture and then sell a product that has an inclusion ratio of “detectable”? Even worse, and a widespread practice, is the inclusion of other compounds not listed on the COA that boost a certain active count, giving a false reading (when we performed a fingerprint analysis on a green tea sample from the Far East, for example, we found a high ORAC value but almost no phenolics as the sample contained Black Wattle — nothing to do with tea).

at such cheap prices that not even the best of intentions can overlook the profit margin that can be enjoyed by using them. The result, ethical extractors have stores filled with excellent products that meet scientific requirements but that sell very slowly, if at all.

The consumer gets a product that doesn’t work and the cycle perpetuates. Owing to the propensity for alternative health products to fail, consumers will stick with allopathic medicines and all the associated chemical toxicities. Surely it would make sense for manufacturers to make products using the proper extracts in the first place (that are still cost-effective to make) and that do not have a known negative effect on either the environment or the person for whom they are intended to help?

The transformation of medicine during the last 4000 years goes like this: • 2000 BC: “Here, eat this root.”

• 1000 BC: “That root is heathen. Say this prayer.”

• 1850 AD: “That prayer is superstition.

Drink this potion.”

• 1940 AD: “That potion is snake oil.

Swallow this antibiotic.”

• 2000 AD: “That antibiotic is artificial. Here, eat this root.”

Making and selling products that actually work, and with which consumers can see the results, would negate the need for enormous marketing budgets to find new audiences.

Existing consumer baselines would effectively market your product for you (by word of mouth), generating natural market expansion.

This would result in a win-win situation, which is not hypothetical; it is entirely achievable … but it is not exactly what the pharmaceutical industry wants to hear right now. I just worry that if the industry doesn’t open its ears and take note, there will be massive regrets in the future. The 21st century is in our hands and if we can hold farmers of raw materials, extractors of actives and contract manufacturers of these products to regulate themselves, we will have amazing products that will work as designed. You decide which option the consumer would ultimately choose and where the long-term gains are to be had.

A Call to Arms Because there is no proper industry regulation, certain regions have been allowed to enter the market and flood it with substandard extracts that are, at times, proven not to even be the plant material from which the extract has supposedly been taken.

These substandard extracts are delivered

For more information Roy Henderson, CEO Green Cell Technologies and Dynamic Extractions and Formulations Tel. +27 21 782 5882 info@greencelltechnologies.com www.greencelltechnologies.com

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All this contained in an allergen-free capsule: Biolatte MADAME. Both products have shown to give an high rate of remission and have been extremely well tolerated.

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functional beverages

Marula Fruit: The Next Beverage Innovation Marula (Sclerocarya birrea) conjures up different memories and images for different people around the world.

I

n Western countries such as Germany, for example, most people know about marula because of Amarula, a marula distillate-based liqueur. Amarula has been marketed for several years and became particularly well known through advertisements linked to the soccer world cup in 2010. In comparison with Western countries, marula fruit preparations have been used for centuries in Africa and are closely connected to the culture of local people. The nutritional and cultural value of marula fruit has been recognized for generations in Africa and is one of the most commonly used indigenous wild fruits in the region.

Marula trees are found right across Africa, from Tanzania in the east, through sub-Saharan Africa to South Africa. The ripe fruit is light yellow in colour with a leathery skin enclosing white fibrous flesh. This flesh, which surrounds a large nut used for its oil, is succulent with a unique acidic and pleasantly refreshing flavour. The fruits are popular with children and are often consumed straight from the tree providing a nutritious and refreshing snack. The juice of ripe fruits has been traditionally prepared in different ways to obtain both alcoholic and non-alcoholic beverages.2 In southern Africa, marula juice extraction is primarily done by the women of the household and the trees are

removed and the pulp remains on the seed. The resulting beverage can be further distilled to produce a strong liqueur.4 The wine, also sometimes called beer, can be purchased in open markets in Africa and it is perceived to be a high value product. Along with various nonalcoholic marula beverages, another popular local product is marula jelly, which is often added to porridge.5 Our marula story began in northern Namibia several years ago when we learnt about a women’s co-operative in Owanboland that was producing oil from marula nuts. The women in the region have used this oil for centuries as a moisturizer and, today, it can be found in cosmetic and skincare products across the world. Our attention was captured and the women of the co-operative then introduced us to the products that can be made from the refreshing fruit pulp. Trading marula products is an important income source for many of the women in the co-operative and they happily relate the impact it has on their lives and families. As more women saw the benefits of joining the cooperative and participating in the marula trade, the co-operative grew and developed, reaching more than 3000 members and impacting on many more. Selling marula products has changed the lives of many women and allows them to pay school fees for their children, pay hospital fees and purchase food.

Another benefit concerns the conservation of the trees and the women tell us how they now protect the trees they harvest from, as well as cultivating new ones. The stories the women tell us about harvesting marula trees and producing the various products has inspired us to help grow and promote this industry.

A key requirement to support the growth of a potential marula industry is to understand the marula fruit composition and its beneficial nutritional effects. In addition, a deep understanding of the ripening process is necessary to implement quality control and harvest timelines and procedures, which comply with industry requirements. Several scientific studies on marula composition have been published, investigating the properties of the trees and the fruits.2,5,6 Those studies that have been published on marula fruit do not seek to understand the phytochemical changes that take place during the ripening process of Namibian marula fruits, nor do they explore how this information can be used to develop the commercial potential of the fruits. It was very clear to us that the women of the co-operative have an intricate understanding of the fruit ripening process and the methods used for processing

“When I think about marula, I think about all the hours we spent under the tree, about the refreshing juice, which I squished out from the fruits directly into my mouth; I think about summer, fun, colourful dresses and the festivals.�

Mapo, 20 years old, Owamba, Namibia

known for their strong cultural significance.3 The marula season starts after the rainy season during spring, a time of natural plenty, ease and happiness. During this period, various marula celebrations, so called marula festivals, take place. Marula wine, Omaongo, plays an important role and is often offered as a gift to the hosts. The wine is produced by fermenting marula juice, from which the skin has been

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strap

the pulp into various end products. However, this knowledge had not been applied to the quality control parameters that are necessary to develop a robust quality assurance programme at the point of harvest.

By correlating the knowledge of the harvesters, and the results of analytical tests, it can be demonstrated to industry that adequate quality control based on ripening characteristics can be implemented to achieve commercial-scale processing. Furthermore, we considered it crucial to identify parameters that could be tested using technical expertise and equipment available locally in Namibia.

With a clear understanding of the supply chain in place in Namibia, we designed our study to investigate the physical (colour, fruit size, firmness) and phytochemical changes (sugar content, acid content, dry matter) that occur in the fruits during the ripening process. Samples from 40 different trees and 8 days of ripening were analysed. The ripening day as well as the preferred day to harvest the fruits was determined.

It was possible to define a time period that was suitable to process the fresh fruits into juice, fermented or non– fermented, or into juice concentrates.

When it came to the identification of the quality of a tree and its fruits, the analytical results of quality control parameters commonly used Katie, 20 years old, Germany in industry were

“When I think about marula, I think about Amarula, about a nice evening with the girls, having fun and chatting about all the important issues in life.�

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compared and correlated with the sociocultural parameters traditionally used by the rural population involved in fruit harvesting and supply.

The colour and the firmness of the fruits change during the ripening process. When the fruits are ripe and ready to eat, they are soft with a nice yellow colour. At the same time the fruits develop a special flavour. These parameters help the harvesters to recognize the best fruits ready to obtain juice. We found a close correlation between the analytical definition of ripeness and those fruits that the harvesters in the field identified as ripe. This indicates the real potential of Namibian harvesters to act as key quality control assessors in the supply chain of marula fruits to the international market. Marula fruits from northern Namibia were found to be an important source of carbohydrates, antioxidants and minerals. The sugar content is relatively stable throughout the ripening process and is similar to other fruits such as mango and pineapple. Besides the nutritional and refreshing benefits,

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marula offers interesting flavour properties. The pH, and therefore References acidity, decreases during the ripening process whereas the sugar 1. F. Gous, et al., “Selection and Processing of Marula Fruit (Sclerocarya birrea subsp. content and secondary metabolites increase. This provides the caffra), Lebensm.-Wiss. u.-Technol. 21, 259–266 (1988).

2. S.E. Shackleton, et al., “A Summary of Knowledge on Sclerocarya birrea subsp. potential to develop beverages of varying sweet to sour profiles, which caffra with Emphasis on its Importance as a Non-Timber Forest Product in South can be customized to meet consumer taste preferences. and Southern Africa, Part 1: Taxonomy, Ecology, Traditional Uses and Role in Rural These new findings demonstrate a real potential to extend the Livelihoods,” Southern African Forestry Journal 196, 67–78 (2002) supply chain and to start the promotion of marula fruit as the basis 3. A. Botelle, A History of Marula Use in North-Central Namibia, Eudafano Women’s for new, innovative beverage applications. A market study showed Cooperative Ltd and CRIAA SA-DC (Windhoek, Namibia, 2001). that there is an increasing market for marula beverage formulations.

4. J. Hall, “Sclerocarya birrea (A. Rich.) Hoscht,” in L. Oyen, and R. Lemmens, Eds., Plant Resources of Tropical Africa, Precursor (PROTA Programme, Wageningen, the Marula fruit is already used as the base for juices, teas and other Netherlands, 2002) pp 127–131. beverages, bringing a unique and exotic twist to juice mixtures, herbal 5.

E. Palmer and N. Pitman, Trees of Southern Africa (Balkema, Cape Town, South Africa, infusions and milk-based drinks. It is often found in formulations 1972–1974) pp 1188–1193. with other topical fruits including pineapple, lychee and passion 6. N. Dlamini and S. Dube, Studies on the Physiochemical, Nutritional and Microbiological fruits or with herbs synonymous with Africa such as rooibos and Changes During the Traditional Preparation of Marula Wine in Gwanda, Zimbabwe,” honey bush.7 Products can be found throughout Africa, Europe and Nutrition and Food Science 38(1), 61–69. (2008).

America. For example, in Brazil several chocolate-based products 7. Mintel GNPD: www.gnpd.com/sinatra/gnpd/frontpage/ (July 2011). with marula aroma were launched in 2008 and 2009 and, during the same timeframe in the US, ice-cream and jams with marula were For more information introduced to the market. In Europe, the launch products were mainly Sybille Buchwald-Werner, founder and managing director, focused around alcoholic beverages, flavoured waters and nectars. and Cynthia Suarez, scientific manager Nevertheless, the total number of products on the market compared Vital Solutions GmbH Hausinger Strasse 4-8, D-40764 Langenfeld, Germany. with other tropical fruits, such as pineapple or passion fruit, is still Tel. +49 2173 1098 202. Sybille.Buchwald-Werner@vitalsolutions.biz small. Marula is an exciting, innovative African fruit that combines the www.vitalsolutions.biz spirit of Africa with great taste and nutritional values. Marula is backed with a secure, ethical and sustainable supply chain and not only Katie Beckett, scientific manager meets industry and consumer demands but promotes the market for PhytoTrade Africa. 5 Calvert Avenue, London, E2 7JP, UK. A5 quer-4c-D-F-E:Layout 1 07.09.2010 Uhrand Seite 3 Tel. +44 207 739 8822. katie@phytotradeafrica.com indigenous African natural products, benefiting rural15:23 producers www.phytotradeafrica.com their communities.

www.stolz-concept.de

We’re taking a (super)critical look at extract quality

FLAVEX ® Naturextrakte GmbH · info@flavex.com · www.flavex.com May/June 2012 www.nutraceuticalmag.com

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functional beverages

The Whey to Long-Term Wellness

Suzane Leser, nutrition manager for lifestyle nutrition at Volac, highlights the long-term

70, this can decline to 20% or less. Maintaining muscle mass and bone density throughout life therefore become critical to our ability to lead a healthy and active lifestyle for longer.

advantages of whey protein in wellness Protein and Healthy Ageing Proteins are required to repair tissue and sustain muscle growth, as drinks.

W

ith life expectancy on the increase, the current focus for many people is on how to live a healthy and active life for longer. In the same way, wellness is no longer seen merely as the absence of disease, but as a condition that individuals can play an active role in creating for themselves. A key threat to our ability to stay healthy and active as we grow older is muscle wastage (sarcopenia), resulting in loss of strength, mobility and functionality.

A moderately active lifestyle, combined with an optimal intake of protein, helps to slow muscle wastage in later life. However, as lifestyles become ever more hectic, time-poor consumers are looking for convenient ways to achieve a healthy diet. Thanks to research and development, whey protein fortified beverages can now offer appetizing solutions to meet these consumer demands.

Muscle Mass Decline Through Ageing As adults enter the fifth decade of life, they begin to experience a slow rate of decline in overall muscle tone and strength — as well as bone density — affecting mobility and quality of life. Protein tissue accounts for approximately 30% of whole-body tissue. However, by the age of

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well as provide energy and function in many other important biological processes. As large molecules, they are broken down upon digestion into smaller clusters of amino acids. They are then absorbed by the body and used to make new proteins that, in turn, become the building blocks of muscle fibres. As EFSA has recently recognized, protein plays a key role in “promoting protein synthesis,” which enables the reconstruction and repair of muscle proteins. It also acknowledges that: “healthy ageing requires the maintenance of bone density. Protein is required for the maximum effectiveness of calcium in the remodelling of the bone matrix.”

As we grow older, our metabolism slows down. This has led to suggestions that the recommended daily protein needs for older people (entering the fifth decade of life) should be higher, as compared with the 0.8 g/kg/d protein recommended for adults in their prime.

One strategy to stimulate muscle protein synthesis to its highest is the intake of fast-digesting high quality proteins. Nutritional support through the consumption of the right balance of high quality proteins with every meal can be an essential dietary requirement for those people who want to follow and maintain an active and healthy lifestyle for longer.

Why Whey?

Derived from milk, whey protein is, biologically, a high-value protein; it contains one of the highest natural concentrations of branched-chain amino acids (BCAAs), which are necessary as building blocks for the synthesis of new proteins and, therefore, muscle. Whey protein also contains a high level of the BCAA leucine — an amino acid that plays a key role in triggering muscle protein synthesis. It can be more easily digested and absorbed by the body than many other proteins. This can be helpful for those over the age of 50 as the metabolism and thus the rate of muscle protein synthesis slows down. Easily digested and fast acting, whey protein has a key role to play in promoting muscle synthesis and, therefore, in protecting the body from the loss of muscle mass in later life.

been without its challenges. A protein that withstands pasteurization and remains clear in solution throughout the shelf-life of a typical near-water beverage has been the subject of much research and development.

Volac, however, has answered the processing critics with the development of Volactive Hydrapro — an enhanced, fat-free whey protein isolate that combines high solubility with heat stability and a long shelf-life. This enables manufacturers to combine the benefits of this high quality whey protein with carbohydrates and fluids in a clear, convenient and refreshing beverage.

Conclusion As we seek to live active and healthy lifestyles for longer, consuming high quality proteins, such as whey protein, becomes vital. However, with hectic lifestyles continuing into the over60s and beyond, consumers require convenience. With the barriers to using whey protein in a ready-to-drink format now overcome by the development of Volactive Hydrapro, manufacturers of wellness drinks can now offer whey protein in a refreshing on-the-go format that will enable consumers to achieve a balanced diet containing adequate amounts of protein for long-term muscle and bone health whilst pursuing a busy and active lifestyle.

Active Lifestyles Demand Convenience In 2011, 868,000 people in the UK will reach 50 years of age; that’s 32,000 people more than in 2010. Evidence suggests that a significant proportion of the over-50 population is committed to leading an active life for longer. Data from the 2008 London Marathon revealed that almost 60% of the 34,500 runners were over 35 years old, and nearly 3% (over 1000 participants) were aged over 60 years. In addition, a BUPA survey published in 2011 suggests that nearly a quarter of over60s work out at least five times a week. As their protein requirement increases with age, maintaining an optimal intake of high quality protein is important to this segment of the population who are committed to maintaining an active lifestyle. However, consuming a healthy balanced diet whilst pursuing an active lifestyle and meeting the pressures of work, although essential, is not so easy.

In this environment, such consumers are constantly searching for ways to successfully manage their lifestyles and are therefore open to new product choices that will help them to stay healthy and active for longer. Whey protein provides the consumer with a busy and active lifestyle the opportunity to maintain that lifestyle for longer — by not only helping to maintain muscles, but also contributing to reduce sugar and fat intake in meals and snacks. This provides potentially rich pickings for innovative manufacturers to develop products that can provide consumers with the optimal nutritional balance whilst combining taste and convenience.

Overcoming the Challenges of Manufacturing Until recently, the addition of whey protein to clear beverages has not

Suzane Leser

For more information

Suzane Leser Nutrition Manager, Lifestyle Nutrition Volac Tel. +44 1223 208 021 enquire@volac.com www.volac.com

May/June 2012 www.nutraceuticalmag.com

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functional beverages

Cholesterol Reduction in Beverages and Spreads

As consumers look for healthy food and drink options, Olivier du Châtelier, business development manager, Cargill Health and Nutrition EMEA, explains below how plant sterols can help to deliver a valuable health benefit in dairy beverages and other products.

H

igh cholesterol is linked with cardiovascular disease (CVD) and, as such, is one of the most pressing global health concerns.

This means that a clinically proven health benefit linked to cholesterol reduction is one of the strongest features an ingredient can have. We all know that heart disease is a big problem in Europe, with CVD causing two million deaths each year in the 27 countries of the European Union. This is 42% of all deaths and costs the EU economy an estimated €192 billion a year.1

CVD: Causes and Potential Solutions There are many different types of CVD, all with different causes.

However, the majority are related to atherosclerosis, which is a condition in which cholesterol, fat and fibrous tissue build up in artery walls. In coronary heart disease (CHD), the arteries that supply blood to the heart are narrowed. Risk of CHD increases according to a number of factors. These include heredity, male gender, advancing age, smoking, obesity, diabetes, lack of physical activity and high blood pressure. However, a high blood cholesterol level is also a significant risk factor. Cholesterol itself is an essential part of our body’s cells. It is produced within the body and transported as part of special particles called lipoproteins, which have several different properties (for example low-density lipoprotein [LDL] and high-density lipoprotein [HDL]).

Cholesterol can also be absorbed from food, and if we eat a diet including excessive saturated fat, we can develop a higher proportion of low-density lipoprotein (LDL) cholesterol — which is strongly linked to the development of atherosclerosis and an increased risk of CVD. The most important common-sense dietary method to lower cholesterol is to reduce the amount of saturated fat consumed, but we can also reduce cholesterol by increasing our intake of certain foods.

Clinically Proven to Lower LDL Cholesterol Plant sterols are clinically proven to lower LDL cholesterol, the form associated with heart disease, without impacting on ‘good’ HDL cholesterol.2 Studies have demonstrated an 8–15% reduction in LDL cholesterol, with no adverse effects. Plant sterols, also known as

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phytosterols, occur naturally in a range of plants. Fruit and vegetables, breads, other whole grain products and most vegetable oils contain some plant sterols. The main problem is that it is difficult to consume enough of these foods every day to take in sufficient plant sterols to maintain normal cholesterol levels — so one way to get an effective amount is by consuming plant sterols that have been added as a functional ingredient.

One such ingredient is Cargill’s CoroWise, a non-GMO plant extract that can be added to low fat and fat-free milk-based drinks without affecting the flavour or texture. An example of CoroWise being used as an ingredient in milk is Avonmore Heart Active milk from Glanbia. This was launched in Ireland towards the end of January this year, where Avonmore is the number one brand, and was backed by a television advertising campaign. Sales are reported to be going well.

Using Sterols in Dairy Food Products CoroWise can also be used in milk-based fruit, soya and yoghurt drinks, providing them with a fresh clean taste and smooth texture.

Other permitted applications (accepted as a novel food ingredient by the EU3) include the following: • yellow fat spreads, excluding cooking and frying fats and butter or other animal fat-based spreads • salad dressings, including mayonnaise and spicy sauces • cheese-type products with a fat content of less than 12 g per 100 g, in which milk fat and/or protein has been partly or fully replaced by vegetable fat or protein • rice milk • rye bread.

CoroWise is available in

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Conclusion

powder, ester (used for oil-based applications) and aqueous dispersible forms for maximum flexibility.

The innovative ES-101E plant sterol powder can be used in dairy and non-dairy beverages and via the fruit preparation/flavouring base for yoghurt/ yoghurt drinks. It does not affect taste and includes a higher concentration of plant sterols than any steryl esters instant version. It also contributes half the calories, with ES-101E at 185 kCal/100 g compared with the water dispersible steryl esters version at 370 kCal/100 g. ES-101E is much easier to handle and incorporate in high concentrations compared with steryl esters and can be stored at room temperature.

Plant sterols are clinically proven in a number of studies to reduce LDL cholesterol. Cargill’s CoroWise creates new possibilities for delivering proven cholesterol lowering benefits in functional beverages and other foods without affecting appearance, taste or aroma. Under current EC health claim regulations, food manufacturers can claim that products containing CoroWise may help to maintain a healthy cholesterol level, thus contributing to heart health.4

References

1. The European Heart Network, European Cardiovascular Disease Statistics 2008 (www.ehnheart.org).

2. www.efsa.europa.eu/EFSA/efsa_ locale-1178620753812_1211902054931.htm.

3. Foods with Added Phytosterols as per Commission Decisions 2004/333/EC to 2004/336/EC. 4. http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009: 277:0003:0012:EN:PDF

Heart Health Products Continue to Grow The demand for heart health products is growing, demonstrated by the number of new products launched in the heart health functional food category. According to market researchers, Innova, in 2009 there were a total of 233 products launched across the EU with a heart health claim, 163 in the food category and 70 in the beverages category.

The figures from Innova also show the sterolenriched food market, too, is booming. Around €1.2 billion of sterol fortified foods were sold in 2011 across the key markets of the EU, Australia, Japan and the US, with annual growth averaging 5–8% in the EU.

For more information

Olivier du Châtelier Business Development Manager Cargill Health and Nutrition EMEA Olivier_duchatelier@cargill.com www.cargill.com

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May/June 2012 www.nutraceuticalmag.com

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functional beverages

The Rise of Relaxation Drinks The nutraceutical soft drink market has been growing at an impressive rate during the last few years (just below 10% per year since 2003); this growth is expected to continue for the next 5 years at least.

T

he largest nutraceutical soft drinks market is that of Japan ($8.3 billion in 2008), followed by the US ($6.2 billion). In Europe, the largest market is the UK ($3.1 billion in 2008), which is twice as large as the German market. Both these countries have enjoyed superior growth rates because of their strong interest in personal health issues and their openness to new products. The biggest growths in the next few years are now expected to be in Spain and France.

With time, the nutraceutical soft drinks market has diversified and now offers a tremendous number of different products. Originally featuring energy drinks, then sports drinks, it has expanded to include functional dairy drinks (probiotics, yoghurt drinks) and now includes many other types of functional drinks such as soy and other non-dairy drinks, juices, healthful sodas, enhanced water, tea and coffee. The growth of the functional drinks market has encouraged levels of innovation and new product development that are probably unmatched in any other consumer packaged goods sector. Although energy drinks and sports drinks still accounted for more than 50% of new functional drinks in 2009, many other functional benefit trends are emerging. New products now target heart health, digestion, beauty, brain function, bone and joint health, immunity, weight control and stress management.

Relaxation Drinks: A Growing Trend Antienergy drinks have also been carving out an attractive niche in recent years. These new functional drinks, also called antienergy or alertness drinks, are formulated to help people unwind or focus better. The first relaxation drinks emerged in Japan in 2005. They quickly spread to the US: 127 million litres were sold on the US market in 2010, which is actually twice what it was in 2008. In the past 3 years, nearly 100 new relaxation drinks — including different sizes and flavours — have appeared on the US market, according to Datamonitor. This new trend in the beverage market has started to emerge in other geographies too, such as the EU. At a time of growing health consciousness, more and more consumers are reaching for drinks that they consider to be healthier, while turning away from carbonated soft drinks. As

www.nutraceuticalmag.com May/June 2012

US consumption trends show that Americans are always willing to try new products, relaxation drinks are set to gain further market share during the next decade. By 2014, US volume sales of relaxation drinks will exceed 300 million litres, according to Zenith International experts.

Such products should also see significant growth in the European market, benefiting from the expected growth of the functional drinks market in that area.

Relaxation Drinks Ingredients Relaxation drinks contain ingredients that are likely to promote sleep or reduce anxiety. The very first antistress drinks were formulated with GABA (gamma amino butyric acid), a neurotransmitter with a relaxing and tranquilizing effect. Other common active ingredients found in relaxation drinks are melatonin, a hormone that has been shown to aid sleep and fight insomnia, L-theanine, an amino acid primarily found in green tea that promotes relaxation; B vitamins and minerals such as potassium, which is associated with muscle relaxation. Another angle that has been pursued under the relaxation banner is that of natural antistress drinks, mainly featuring herb extracts. Although most of these new drinks have not undergone clinical trials as such, at least some of their ingredients have been shown to be effective. However, these ingredients are often used at levels that may be too low to be effective.

An Effective Stress Relief Ingredient Lactium is a GRAS, patented, 100% natural ingredient based on a milk protein hydrolysate that contains a bioactive peptide and is proven to help manage stress. This ready-to-use ingredient can be incorporated into liquid matrixes at the recommended dosages. Moreover, it is suitable for the formulation of translucent beverages. Lactium does not suppress stress factors but helps consumers to deal with occasional or everyday stress, decreasing stress-related symptoms such as sleep disorders, impaired memory and concentration, mood disorders and weight gain, for example. Discovered by Ingredia Nutritional’s R&D team, in collaboration with academic research a decade ago, the soothing properties of Lactium have been assessed by numerous clinical studies.

Indeed, it has been clinically proven that Lactium reduces stress-related symptoms, based both on individual statements and physiological stress parameter measurements.

Clinical Evidence of Stress-Moderating Properties

Lactium’s efficacy has been assessed at different daily intakes and during short and long periods of use. An initial study assessed the effect of a daily intake of 150 mg of Lactium compared with a placebo for 30 days on stress reactivity in healthy subjects.

Results revealed that blood pressure reactivity after mental stress was lowered by a daily oral intake of 150 mg of Lactium for 30 days. This effect was particularly significant in high stress responders. This study demonstrated Lactium’s efficacy compared with a placebo for chronic stress management when used for at least 30 days. Another study, performed in the Clinical Investigation Center of Necker-Enfants Malades Hospital (Paris, France) focused on evaluating the effects of a high intake of Lactium (400–800 mg) on physiological responses to stress in acute conditions. Results showed that Lactium

“At a time of growing health consciousness, more and more consumers are reaching for drinks that they consider to be healthier, while turning away from carbonated soft drinks.” consumption regulated haemodynamic parameters during stress tasks, when compared with a placebo. This study highlighted Lactium’s ability to help consumers deal with acute stress. A study performed on females with stress-related symptoms aimed to investigate whether a daily intake of 150 mg Lactium for 30 days would modify various stress-related symptoms in physiological, psychological and social areas. After the 30day supplementation, Lactium (150 mg/day) induced significant improvements in five areas: digestive, cardiovascular, intellectual, emotional and social troubles for the subjects who showed the highest intensities of their major symptoms. This study showed that Lactium has a true stress-relief efficacy on stressed people. An additional study evaluated the efficacy of Lactium intake for 28 days on sleep disorders, based on the fact that the most commonly occurring forms of chronic insomnia are associated with stress, anxiety and mild depression. The Lactium or placebo products were consumed daily for 28 days and subjects assessed their sleeping-disorder improvement by filling in a self-rating questionnaire. Lactium showed a positive impact on sleep quality, sleep latency and daytime dysfunction. As a consequence, Lactium can be used in the formulation of sleep quality improvement products. The most recent study aimed to determine the effect of mild (14 days) and long-term (42 days) consumption of 150 mg and 300 mg of Lactium, respectively, in healthy subjects when submitted to stress. In addition to the positive effect of Lactium on haemodynamic parameters at a daily intake of 150 mg, which was confirmed, its efficacy was also proven for a daily intake of 300 mg during 15 days. These soothing properties were measured using both physiological parameters, such as systolic

functional beverages

By combining clinically proven soothing properties, both in acute and chronic stress conditions, and a remarkable industrial flexibility, Lactium offers multiple options for the formulation of relaxing drinks, backed with persuasive communication towards consumers. Depending on Lactium’s dosage and period of use, such beverages can be designed for stress prevention (150 mg/day), chronic stress management (300 mg/day) or acute stress relief (600 mg/day). Always willing to help its customers innovate and find new market opportunities, Ingredia Nutritional has imagined a full range of Lactium-based relaxing drink concepts. This portfolio of finished products comprises ten relaxing drinks that target the Serenity family: a representative, modern, Westerntype household composed of two active adults, one teenager and one child. Each member of the Serenity family is likely to face stressful situations at work, at home or at school. Unfortunately, it only takes one stressed person to impair the quality of life of his/her whole family.

Those functional drinks are designed to preserve the quality of life of the Serenity family by helping one or several members control or even prevent stress. The time of recommended intake can also differ depending on the targeted benefit: in the morning to stay calm all day, at night to promote sleep, to help stop snacking or quitting smoking without stress, to promote certain skills or for an immediate soothing effect etc. Each concept of this range has been carefully considered to be specifically adapted to the expected population and benefit.

This innovative range includes soda cans to help cope with acute stress, “good night” milky shots to fight chronic sleeping disorders, soothing syrup for children and an “easy detox” beverage to deal with tobacco-withdrawal symptoms — all providing the correct amount of Lactium. The turnkey concepts of this range can all be used as is or be customized in terms of flavouring, packaging, etc. Besides, they are also meant to be a source of inspiration for Ingredia Nutritional customers. In all cases, this concept range aims to helping them make the best of this remarkable ingredient and launch innovative products that keep them one step ahead of their competitors.

For more information Harmony Villemin Product Manager IDI Inc. (Ingredia Group) h.villemin@ingredia.com www.ingredia.com

www.nutraceuticalmag.com May/June 2012

Variation between the average SBP on S1-S5 and the rest value Variations (Vn-V1)

A Range of Innovative Concepts

2

Placebo (N=52) Lactium 300mg (N=55) 0

-2

-4

-6

-8

V1

V2

V3

Figure 1: Variation in systolic blood pressure (SBP) in stress and rest situations.

2

Variation between the average HR on S1-S5 and the rest value Variations (Vn-V1)

blood pressure and heart rate (Figures 1 and 2) and level of anxiety (Figure 3). This study demonstrates the efficacy of a daily intake of 300 mg of Lactium on acute stress management when used for at least 14 days.

Placebo (N=52) Lactium 300mg (N=55) 0

-2

-4

-6

-8

V1

V2

V3

Figure 2: Variation in heart rate in stress and rest situations.

4

Placebo (N=52) Lactium 300mg (N=55) 2

STAI Score Variations (Vn V1)

44

0

#2

#4

#6

V1

V2

Figure 3: STAI questionnaire scores recorded during the study.

V3

46

functional beverages

Going for Gold Interest in sport is higher than ever this summer. Consumers are increasingly looking to mimic the success of their heroes and there is growing interest in sports nutrition — an important part of the training process — as a result.

A

s healthy consumers become more aware of the benefits of sports nutrition, drinks manufacturers have been quick to ride the sports fever wave and find innovative solutions for formulation. In particular, the advantages of consuming protein are becoming more appreciated, and manufacturers are looking at different ways of incorporating proteins into beverages.

Protein Power

Sales of sports drinks have increased steadily since 2009, with new figures showing that worldwide sales reached 15,000 litres in 2011.1 Sports drinks have now shed their ‘bodybuilder’ image as recently launched products aim to attract not only elite athletes, but sports enthusiasts of all levels. Drinks manufacturers are shifting their attention to protein-fortified sports beverages as the potential benefits of protein are becoming well documented and its important role in muscle synthesis takes centre stage. Protein molecules contain branched chain amino acids called leucines, which may help to support muscle growth and development by stimulating muscle protein synthesis.

Consumers are being encouraged to increase protein intake, and the Food Standards Authority in the UK now recommends a daily intake of 55 g of protein to maintain a healthy diet.2

Preparing for Success

Athletes must consider their pre-, during and post-exercise nutritional requirements. To prepare their bodies for a workout, athletes consume protein to increase the amount of amino acids available to muscles during exercise.

Recovery Time

After exercise, athletes need to increase their levels of key nutrients to boost immunity and to prevent oxidative muscle stress. Again, protein plays a pivotal role in the recovery phase as it can help to repair muscle tissue and build muscle mass. Drinks manufacturers have often been presented with challenges when formulating with protein in sports beverages. To overcome this, manufacturers are innovating with ingredient solutions. ADM, for example, has recently launched CLARISOY to help add protein to clear beverages that would ordinarily cloud. A transparent, isolated soy protein, CLARISOY is the world’s premier plant-based protein to provide clarity and 100% solubility in sports drinks. CLARISOY 100 is the first product in the range and offers manufacturers the ability to deliver five or more grams of protein per serving in transparent beverages with a pH of less than 4.0.

The Future

Consumer demand remains high for convenient sports beverages with specific functionality. There are a wide variety of ingredients that can be easily formulated into sports beverages, and tailored to suit the needs of athletes at different stages of exercise. Recent innovations in the sports nutrition market, and a continued growth in the number of nonelite athlete consumers, mean the sector is set for sustained success.

References

1. Euromonitor, Sports and Energy Drinks Market Sizes (January 2012).

2. Food Standards Agency, FSA Nutrient and Food Based Guidelines for UK Institutions (2006).

For more information

Bruce Bennett General Manager, ADM Specialty Products — Oilseeds ADM International Sàrl A One Business Center ZA Vers de la Pièce, Route de l’Etraz CH-1180 Rolle, Switzerland.

Tel. + 41 21 702 8000 media-eu@adm.com www.adm.com

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functional ingredients

Pa r t 2

Strength in Numbers

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the effect created when complementary taste profiles are combined.

When a number of sweeteners, each of which possesses different qualities, are mixed, it is possible to identify the characteristics of each component, but individual qualities are expressed to a lesser intensity.

Formulating with just one sweetener will require high dosages of the HIS, meaning that its more intensive off-notes will be noticed. Mixing high-intensity sweeteners enables the creation of additional flavours that go beyond sweetness, such as bitterness, liquorish flavours, cooling effects and metallic or soap-like tastes. Combining several high-intensity sweeteners may help to dilute off-tastes.

Another potential benefit to be gained by using combinations of two or more sweeteners relates to the sequence of sweetening and flavour appearance. This can be seen when one ingredient appears first, or lasts longer, whereas another has a later onset or ends earlier.

In such a case, the combination of both ingredients complements the sweetness profile, ensuring a harmonious flavour. This phenomenon also provides an excellent means of achieving sugar-like tastes in reduced sugar or sugar-free products.

Fructose has been found to possess characteristics that make it a particularly effective ingredient when combined with other sweeteners, particularly steviol glycosides. When the latter are combined with fructose, the previously mentioned phenomena are expressed to particularly good effect. To achieve the required sweetness level, both

C

M

Y

CM

MY

Fructose INTENSITY

S

tevia extract sweetener has been known and used for hundreds of years in South America and has been approved for use in foods and beverages for more than 40 years in Japan.

Purified steviol glycosides are now approved as safe, high-potency natural sweeteners by regulatory boards worldwide. Their main benefits incorporate high stability at high temperatures, including UHT processes, stability across a wide pH range (3–8) and suitability for products with a long shelf-life. What’s more, they offer a non-toxic, non-carcinogenic, plaque-retardant, anticaries, low Glycaemic Index (GI), natural sweetening alternative that enables the development of products with significant sugar and calorie reduction.

In the first part of this article, we explained the origin of steviol glycosides, why stevia-based sweeteners hold new promise for natural high intensive sweeteners (HIS) and presented the benefits of steviol glycoside in creating reduced-sugar, naturally sweetened products. We also examined the challenges associated with replacing sugar and formulating with this natural sweetener, including replacing the bulk of sugar and overcoming the absence of its contribution to formulation. We demonstrated the flavour profile and characteristics of steviol glycosides, including off notes that may be described as bitter/ liquorish/metallic and the lingering aftertaste. We also indicated that a good means of overcoming such challenges is combining steviol glycosides with other sweeteners and that particularly successful results are achieved when combining them with fructose.

Fructose (ß-D-fructopyranose), also known as fruit sugar or laevulose, is a simple carbohydrate. Found mainly in fruits and root vegetables, it is a highly soluble sugar (80% at 20 °C) and is characterized by a high relative sweetening value (RSV) of 1.2–1.7 (sucrose RSV=1), which depends principally on temperature and pH conditions. The lower the temperature and pH, the higher the fructose RSV will be. Therefore, a fructose RSV of 1.7 may be obtained by using fructose in food and beverages such as yoghurts and fruit juices, which are characterized by a low pH and consumed chilled.

Fructose’s key features include a high level of sweetness, flavourenhancement capabilities, ingredient synergy, shelf-life stability, high solubility, browning, humectancy, a high freezing point depression and a low viscosity level. This unique combination makes it an ideal ingredient for lower-calorie food formulations. Fructose has been found to have a low Glycaemic Index (Gl=20), with a slow release of energy that is not insulin dependent and its low water activity level increases shelf-life and improves texture and mouthfeel.

Fructose’s various sweetening characteristics come into play when attempting to formulate for different applications. For example, in carbonated soft drinks, fruit beverages and fruit preparations, fructose can offer potential calorie reductions of 15–20%. In addition to intensifying fruity flavours, fructose also shows special flavourenhancing interactions, enabling the formulation of quality fruitflavoured beverages. In frozen dairy applications, its high freezing point depression ability enables the formulation of softer, ‘spoonable’ and ‘creamy’ ice creams. In bakery applications, the water activity (aw) decreases by up to 0.05 when 30% of the sugar content is replaced with fructose, improving the baking process and assuring a longer shelf-life.

The potential of combining sweeteners to achieve optimal flavours is proving invaluable to food and beverage developers. The impact of these combinations has various possible explanations, for example

CY

CMY

Sucrose K

Dextrose TIME Figure 1: The sweetness response of different sugars.

sweeteners are used in lower dosages and, as a result, the steviol glycosides’ ‘off notes’ are reduced dramatically, their lingering taste is suppressed and the overall flavour of the product is greatly improved.

Fructose has a unique sweetness profile: rapid appearance and short duration. When considering Figure 1, it becomes clear that combining fructose with other sugars such as sucrose can result in improved sweetening characteristics.

Moreover, when fructose is combined with steviol glycosides, its rapid sweetness appearance balances their relatively late onset, preventing ‘emptiness’ in the initial sweet sensation and balancing the overall product’s sweetness flavour. The late onset of steviol glycosides is compensated by the rapid appearance of fructose and any sweetness drop is accommodated by the continuity of sucrose’s sweetness sensation.

The rapid appearance of fructose is believed to activate the taste sensors and allow the flavours in formulations to be better expressed. Furthermore, fructose’s sweetness profile is harmonious

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functional ingredients

Pa r t 2 with that of steviol glycosides, particularly considering their key formulating drawbacks; a lack of mouthfeel and lingering taste.

The additional incorporation of soluble fibres such as inulin, FOS (fructo-oligosaccharides), polydextrose or gums can further enhance mouthfeel to more closely imitate a real sugar taste. Blends that combine steviol glycosides with fructose have proved to be particularly successful, owing to their ability to significantly reduce calories and sugar and still offer a natural, sweet-tasting solution.

Many successful applications have employed the use of sweetening blends containing sucrose, fructose and steviol glycosides to obtain a 30–70% sucrose reduction without necessitating the addition of any sweetening enhancers or masking agents. As with any truly successful sweetening synergy the combination of sweeteners must consider the overall flavour profile of a product, incorporating bitterness, sourness, acidity and more. Galam’s food and beverage application teams have

Ingredients

Reference (%)

Grapefruit Juice (%)

Milk (3% fat)

81.780

84.850

Water

10.000

10.000

5.500

—

Sucrose Fruitose (crystalline fructose)

—

2.315

Potato starch

1.000

1.000

Stabilizer

0.022

0.0220

—

0.095

HiSweet 3500b* Instant coffee

0.600

0.600

Flavour

0.100

0.100

Soluble fibre

1.000

1.000

100.00

100.00

Total * HiSweet 3500b - based on Reb-A 95% and fructose

Sweetness intensity (%RS)

Table I: Ingredients of a reduced-sugar iced coffee sweetened with HiSweet stevia.

Steviol Glycosides

Fructose

Sucrose

formulation carries its own unique challenges. The task is made particularly complex because sweetness levels are not the only factor influenced when sweetening ingredients are introduced. Manufacturers across every food and beverage category are concerned with the technological impact of their choice of sweetener. Potential impacts range from texture, mouthfeel, product appearance and aftertaste to the enhancing and screening of additional flavours, cooling effects in the mouth, product stability, browning, its affect on freezing/melting qualities and the sounds produced when chewing — not to mention an abundance of further challenges that inevitably emerge during the

Time (sec) Figure 2: Sweetness response of sucrose, fructose and steviol glycosides (95% purity) in water solution (room temperature, pH 6.8).

found the steviol glycosides/fructose combination to work across a number of applications. In fruit preparations an optimal balance between sweetness and sourness can be achieved to help to reduce aftertastes and remove the need for masking agents. In dairy products the lack of mouthfeel resulting from sugar and fat reduction can be overcome and in yoghurt applications the combination can reduce bitterness and aftertaste. Furthermore, cocoa-based drinks benefit from improved sweetness intensity and enhanced original flavour.

Tables I and II are two examples of formulations in which combinations of crystalline fructose and steviol glycosides replaced significant amounts of sugar. In the first, Galam’s sweetening experts were required to reduce the sugar content of an iced coffee formulation; they managed to reduce 56% of the sugars in addition to achieving a sugar-like sweet taste and fullness for the new formulated product by replacing sugar with fruitose (Galam’s crystalline fructose) and stevia. Such a product provides an ideal example of the impact of the synergy between the two natural sweeteners.

The beverage market sector is a very important one to stevia sweetened products — and it has experienced a significant annual growth in countries where steviol glycosides have been approved.

Galam’s sweetening experts responded to the challenge of reformulating various fruit-flavoured soft drinks by significantly reducing the sugars (by approximately 50%), without affecting the sweetness level or flavour.

The principal aim of sweetening blends is to provide maximum sweetness in minimum quantities and achieve a sugar-like taste.

However, this is an intricate process and every application and

www.nutraceuticalmag.com May/June 2012

Ingredients

Reference (%)

Grapefruit Juice (%)

85.35

90.69

4.00

4.00

10.50

1.97

-

3.14

0.15

0.14

-

0.06

100.00

100.00

Water Grapefruit base Sugar Fruitose (crystalline fructose) Citric acid HiSweet 3500c* Total * HiSweet 3500c - based on Reb-A and fructose

Table II: Ingredients of a grapefruit juice sweetened with HiSweet Stevia.

production process. Good sweetener synergy holds much greater promise than improved potential sweetness; in fact, it can enhance the products’ overall taste profile. This revelation has significantly altered approaches to formulating new products and has had a big impact on the food and beverage industry — now each application can have a unique, optimally blended flavour.

Authors

Dr Fernando Schved, VP Business Development and R&D, Batia Hassidov, Food Applications Department Manager and Sharon Galperin, Corporate Marketing Manager, Galam.

For more information Sharon Galperin Corporate Marketing Manager Galam Tel. +972 4637 5026 galperin@galam.co.il www.galam.co.il

Bioriginal Europe/Asia – May 2012 Vitafoods Preview At Vitafoods Europe 2012 Biorginal will launch a new product range:

Bioriginal emulsions A market innovation to attract new supplement consumers.

Bioriginal emulsions bring a new option of consuming Essential Fatty acids / Omega’s in an easy and pleasant way.

These healthy emulsions have a great taste and a smooth and creamy texture.

Bioriginal emulsions can be consumed with food products (e.g. ice-cream) but also are delicious to eat straight from a spoon. One spoon (8ml) of Bioriginal emulsion provides the daily doses of the essential Omega’s/essential fatty acids.

The bioavailability of the Essential Fatty acids has been proven to be higher if they are consumed via emulsion. See below the graph summarizing several studies.

More efficent uptake of EPA & DHA from Emulsions 400% 350% 300% 250% 200% 150% 100% 50% 0%

EPA+DHA through oil

EPA+DHA through emulsions

EPA+DHA through capsules

Bioriginal emulsions offer new options for your brand. There are many options, different Essential Fatty Acids – both from marine and plant sources, different flavours, sweetener and vitamin options are possible.

Bioriginal can provide the complete emulsion including packaging & labelling.

Come to visit our stand speak with the Bioriginal team about the options and taste the delicious Bioriginal emulsions.

Bioriginal Europe/Asia Standnumber 1243.

Bioriginal Europe/Asia BV Bosland 40, 3258 AC Den Bommel, Netherlands www.BioMegaSDA.com www.Bioriginal.nl info@bioriginal.nl

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functional ingredients

Boosting the Benefits of Omega-3s with Olive Polyphenols To date, omega-3 fatty acids and phytosterols are understood to constitute an effective approach to decreasing levels of low-density lipoprotein (LDL) and cholesterol.

However, it is also necessary to focus some attention on the oxidized LDL species that already exist in the arteries.

www.nutraceuticalmag.com May/June 2012

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functional ingredients

H

alf of the deaths in Europe are currently attributed to cardiovascular diseases. According to the American Heart Association’s statistical update on heart health and stroke, artherosclerosis accounts for nearly 75% of all heart disease-related deaths. Artherosclerosis, the thickening and hardening of the walls of the arteries, is a process promoted by LDL that becomes oxidized by free radicals. “Our aim,” said a Genosa spokesperson, “is to raise consumer and industry awareness about the benefits of adding olive polyphenols — such as hydroxytyrosol — to their omega-3 formulations, so that the potential for preventive health is doubled: a reduction in cholesterol and triglycerides and, at the same time, the ability to protect that cholesterol from oxidation.” Usually, the company added, people who suffer from high levels of cholesterol also have elevated levels of oxidized LDL. Last April, olive polyphenols (standardized according to hydroxytyrosol content) received a positive opinion from EFSA on the basis that they contribute to the protection of blood lipids from oxidative stress.

Wishing to identify whether omega-3 consumers — whether obtained from foods or dietary supplements — would be willing to continue their consumption if Hytolive was added to them, including a slight cost increase, Genosa tasked TNS (a Spanish market research and opinion survey company) with the job of conducting such a poll.

The survey took place in Spain earlier this year (16–20 February 2012), involving consumers from different geographical parts of the country.

The number of participants was 1032, comprising 538 men and 494 women. They were asked: “How often do you consume products that have a high content of or are rich in omega-3s?” Almost 650

“Olive polyphenols recently received a positive opinion from EFSA on the basis that they contribute to the protection of blood lipids from oxidative stress.”

Hytolive Gets GRAS Status

Genosa has gained GRAS status for Hytolive. A panel of independent experts has deemed Genosa’s olive fruit extract, Hytolive, to be safe for human consumption.

For safety assessment purposes, a maximum intake of 43 mg/person/day of hydroxytyrosol is considered to be appropriate. Hytolive is an olive fruit extract with a rich composition of natural hydroxytyrosol, obtained using a physical/ mechanical, solvent-free extraction process that is internationally patented.

Hydroxytyrosol is the most abundant and active orthodiphenol derived from virgin olive oil and table olives.

In addition, a European Food Safety Authority (EFSA) panel recently approved the claim that “a cause and effect relationship has been established between the consumption of olive oil polyphenols (standardized according to the content of hydroxytyrosol and its derivatives) and the protection of LDL particles from oxidative damage.” This is considered to be a key decision in the recognition of hydroxytyrosol as a component for the treatment of cholesterol. To bear the claim, 5 mg of hydroxytyrosol and its derivatives in olive oil should be consumed daily.”

Genosa is a Spanish company that has made significant investments in R&D, production and the commercialization of a natural, purified and selective extract that is rich in natural hydroxytyrosol in a very competitive way.

participants stated that they consume omega-3 one or more times per week (30%), one or more times per month (19%), sometime during the year (14%) or infrequently (7%). Thirty per cent of the participants did not, apparently, consume these kinds of products.

Those 649 people were then informed about the properties of Hytolive — a 100% natural extract obtained from the olive fruit, using only a physical/mechanical, solvent-free extraction process. They were told that Hytolive is rich in hydroxytyrosol, the most abundant and most active polyphenol (antioxidant) present in table olives and virgin olive oil, and were informed about its potential benefits for cardiovascular health and the “attractive combination of omega-3 and Hytolive in terms of reinforcing its performance by using a complimentary approach.” After this explanation, the were asked: “Now you know about Hytolive, would you be willing to pay a bit more if it was included in any of the omega-3 products that you consume?” The results were as follows: • 73% of those polled said yes (74% men and 73% women) • men and women showed almost identical behaviour, so sex is not a decision driver • by age, the most willing people are 35–44 years old (77%) and 45–54 years old (74%) • the percentages are also similar in the different Spanish geographical areas • no significant differences were detected regarding social status • civil status was not relevant, although married people and couples showed a higher predisposition (73% and 80%, respectively).

Genosa felt that it was important to underline such promising results despite the current hard economical situation in the country.

For more information

Carlos Peña Genosa I+D, SA Parque Tecnológico de Andalucía c/Iván Paulov, 8(1A) E-29590 Campanillas, Málaga, Spain.

Tel. +34 952 028 580 info@genosa.com www.genosa.com

www.nutraceuticalmag.com May/June 2012

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functional ingredients

What’s Good for the Goose The population as a whole is ageing at a rapid rate, and the realities of age-related deficits such as the reduction of cognition, memory, learning tasks and incidences of stroke are rising.

The boomer generation, experiencing these effects, has contributed significantly to the market growth of cognitive support supplements; the segment has exceeded $300 million in sales in the US.

T

he market for solidly researched and safe brain health supplements will simply continue to grow. However, brain health is not just about focusing on the brain — it is a holistic matter. As evidenced by the “French Paradox,” a population that eats polyphenol-rich foods tends to have lower heart disease and stroke rates. A healthy cardiovascular system may lead to healthier brain function. Flavanoids have been studied for half a century; but, in the past decade, an abundance of studies strongly suggest its antioxidant power. The precursor to unhealthy levels of inflammation includes the presence of oxidative stress and, if one remembers, unhealthy levels of inflammation can lead to brain-related health issues. The function of antioxidants is not to remove harmful oxidants entirely but, instead, to keep them at a level below which they will not trigger an unhealthy inflammatory response. Polyphenols, extracted from red wine, which were later discovered to be flavonoids and resveratrol, may inhibit oxidative stress, thus leading to the explanation of the “French Paradox.” Some years back, the Lancet published an epidemiological study in the Netherlands, the “Zutphen Study,”

suggesting that there might be an inverse correlation between the incidence of stroke and the dietary intake of flavonoids. In this instance, the focus was on whole brain health, strokes, etc., and not just memory function. Since that study, flavonoids, the six subtypes (flavan3-ols, flavanones, flavonols, flavones, anthocyanins and isoflavones) and other polyphenols have demonstrated beneficial effects towards healthy ageing and maintaining healthy brain function. Among the flavonoids, only fisetin and quercetin were able to maintain intracellular antioxidants in the presence of oxidative stress.

Cyvex’s Cognisetin is a patented ingredient licensed from the Salk Institute for Biological Studies and recently received a Notice of Allowance (NOA) for a key patent specific to methods of using flavonoids to enhance memory by the US Patent and Trademark Office, titled “Methods of Using Flavonoids to Enhance Memory.”

Cognisetin, as a flavonol subclass of flavonoids, is not only a powerful antioxidant, in that it maintains mitochondrial function in the presence of oxidative stress, “but what makes it unique,” states Dr Puya Yazdi, medical director at Cyvex, “is its ability to be permeable through the blood brain barrier, directly affecting healthy mitochondrial function in relation to ATP levels in the brain.” Cognisetin helps to promote healthy brain function by modulating the brain’s supply of neurochemicals (neurotransmitters, enzymes and hormones) and maintaining a healthy oxygen supply to the brain. In addition to Cognisetin being nootropic, promoting healthy memory and cognitive function, it is also considered to be a sirtuin activator, like resveratrol in wine. (Also, interestingly enough, a sirtuin activator may correspond to the Caloric Restriction Theory of Ageing.) Further investigation and subsequent published studies on fisetin in peer reviewed academic journals led to a 2 year grant from the Michael J. Fox Foundation that validated Cognisetin’s support in vivo. The main point, for continued healthy brain function, is to keep levels of inflammation at a healthy level. Maintaining healthy levels of inflammation requires keeping oxidative stress under control.

Keeping oxidative stress under control is not only good for the heart, but also for the brain. Maintaining a healthy brain and participating in a healthy ageing lifestyle requires a holistic approach. Sometimes what is good for the heart is not good for the head, but in this case, it’s good for both.

For more information Dr Puya Yazdi Medical Director Cyvex Tel. +1 949 622 9030 www.cyvex.com

www.nutraceuticalmag.com May/June 2012

Study consisted of two steps: Step 1: supplementation with Ubiquinone (Q10) Step 2: supplementation with Ubiquinol (QH) for those volunteers who did not feel any beneficial effects with Q10

Conclusion: More than 70% of the non-responders to Ubiquinone felt the “energizing” effect with Ubiquinol within only 10 days and with a dosage of only 100 mg.

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functional ingredients

Nature’s Secret It is no secret that berries can contribute to overall health and wellness; they possess potent antioxidant capacities and are packed with phytochemicals, which research has linked to a multitude of health benefits. One berry in particular has been gaining popularity in the US for its studied health benefits and particularly high antioxidant capacity.

A

lthough it has thus far maintained a rather inconspicuous status, despite its incredible wellness benefits, those who have discovered the aroniaberry recognize it as one of the original and true superfruits — and for that reason, it may just be nature’s best-kept secret. Aroniaberry (Aronia melanocarpa) is a deciduous shrub that is native to North America but was introduced to Russia in the late 1800s. Since then, most of its cultivation has been unique to central and eastern European countries, namely Poland. Jan Mills, president of Artemis International, Inc., pioneered the movement to bring aroniaberry cultivars from Poland to the US in the 1990s, placing them in universities around the country to study the propagation and health benefits of the unique berry.

Researchers have discovered that aroniaberry (also known as chokeberry, not to be confused with chokecherry) ranks consistently among the top fruits in terms of antioxidant levels. The oxygen radical absorbance capacity (ORAC) value measures the antioxidant activity of foods in human tissue. Compared with other raw fruits and berries, the ORAC value for aroniaberry (16,062 µmol TE/100 g) is roughly four times the value of pomegranates (4479), three times that of blueberries (4669) and red raspberries (5065), two and a half times that of blackberries (5905), two times that of blackcurrants (7957) and one and a half

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times the value found in cranberries (9090).

The aroniaberry’s high antioxidant value is a direct result of its exceptionally high content of anthocyanins — the colour pigments that give it its almost black appearance: the darker the berry, the higher the anthocyanin content. It has among the highest-known anthocyanin levels, placing it above other North American cultivated berries and well-known superfruits. In addition to antioxidant activity, researchers have been investigating its effects in the areas of cardiovascular disease, cancer, inflammation response, immune support, gastric support and glucose metabolism.

Research is currently under way to further our understanding of the mechanisms of action involved in its health benefits, but the observed positive effects appear largely to be a result of its unique and potent anthocyanin profile. For example, several studies have demonstrated the ability of aroniaberry anthocyanins to inhibit lipid peroxidation — this may be one mechanism by which it offsets free radical induced cardiovascular disease states.

In the area of cardiovascular health, studies have shown that not only does the aroniaberry possess antioxidant benefits, but it has the ability to reduce blood pressure, improve circulation and blood lipid profiles and reduce markers of inflammation that are linked with cardiovascular disease.

In a human clinical trial, subjects taking

aroniaberry anthocyanins experienced a decrease in systolic and diastolic blood pressure, a drop in LDL-oxidation and a reduction in C-reactive protein (CRP), a factor involved in inflammation. In another human pilot study, subjects who consumed aroniaberry anthocyanins experienced an increase in flow-mediated dilation of the brachial artery, indicative of improved circulation. A newer human study, conducted in 2011, revealed that 1 month of aroniaberry supplementation resulted in the normalization of hemostasis parameters in patients with Metabolic Syndrome, as well as favourable changes to the overall potential for plasma clotting, clot formation and lysis and in the lipid profiles of the subjects.

Animal studies in the related area of glucose metabolism have also shown that this superfruit has an antihyperlipidemic effect in rats with hyperlipidemia and the ability to decrease cholesterol and lipid peroxidation in diabetic rats. Humans who consumed aroniaberry juice for 3 months exhibited lower fasting glucose levels and improvements in glycosylated hemoglobin levels, total cholesterol and lipid levels.

The aroniaberry has also been extensively studied in cancer research. Preliminary studies showed that, compared with various other fruits, a standardized aroniaberry extract was the most potent inhibitor against colon cancer cells and revealed a greater growth inhibition of colon cancer cells

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functional ingredients

than non-tumorigenic normal colon cells. When placed into animal models, the aroniaberry extract exhibited a protective role in colon carcinogenesis by reducing the number and size of aberrant crypt foci and lowering colonic cell proliferation.

Additional health benefits observed include antibacterial and antiviral effects in vitro, antiinflammatory activity in animal studies, protection against hepatotoxicity and a significant protective effect on gastric mucosa against gastric hemorrhagic lesions in a dose-dependent manner in rats. Antioxidant activity has been extensively studied both independently and as part of other experimental designs and shows a definite trend towards the aroniaberry demonstrating significant antioxidant activity, either directly or indirectly. In one study, aroniaberry juice produced a significant drop in the free radical damage induced by strenuous rowing exercise in human subjects.

The benefits observed in research studies suggest great promise for the aroniaberry in a range of commercial applications to support various aspects of health. The berries, their juice concentrates and powders and their standardized extracts are suitable for use in both functional foods and supplements. The increasing interest in formulating beverages and foods to include it is a sign that the market is embracing this unique berry. A renewed venture in cultivating the berries in the Midwest of America has many US growers developing recipes for jams, jellies, juices, sauces and salsas. Commercially, aroniaberry concentrate is also used in the food industry as a colourant to supply a natural red-purple hue in products with poor colour stability or simply to enhance colour generally.

In the dietary supplement industry the standardized extracts, juice powders and juice concentrates are used in the manufacture of capsules, tablets, stick packs, chewables and other product forms. With a standardized extract, formulators are able to deliver a precise and consistent level of the beneficial aroniaberry anthocyanins in each serving. An increasing number of supplement formulators are seeking to include this unique, high-ORAC berry. However, although their popularity is growing, they are still less accessible and palatable in their raw form when compared with other berries, which makes dietary supplementation a popular alternative means of benefiting from all that aroniaberries have to offer.

For more information

Melanie Bush Director of Science and Quality Communications Artemis International, Inc. mbush@artemis-international.com www.artemis-international.com

www.nutraceuticalmag.com May/June 2012

Collagen Peptides in nutricosmetics Improving skin structure from within

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62

sports nutrition

Sports Nutrition: A New Kid in the Blocks Coenzyme Q10, a vitamin-like nutrient, shows performanceenhancing effects in athletes. And, with its active form, ubiquinol, recently becoming available, new opportunities are opening up for sports nutrition.

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lready well known in the cosmetics and medicinal sectors, coenzyme Q10 and its active form, ubiquinol, have been largely underestimated in the field of sports nutrition before now. This might be because, for many years, the permissible daily intake of coenzyme Q10 was limited to 30 mg; and, early study results were based on dosages that were too low to show any beneficial effects. Today, higher doses are allowed in the EU and new studies with higher dosages of up to 300 mg have demonstrated better and more useful results for athletes. It seems that the time is now right for Q10 to make its way into a new generation of sports nutrition products.

Amateur and professional athletes alike can benefit from supplementation with ubiquinol or Q10, as all types of physical training lower the body’s Q10 levels. As a consequence, energy is produced less efficiently and performance decreases. In addition, low ubiquinol levels make the body more prone Q10 and ubiquinol act as powerful antioxidants against free radicals in the mitochondria.

www.nutraceuticalmag.com May/June 2012

to attack from harmful free radicals, which are produced in the body’s cells during physical stress. Studies have also shown that supplementation with ubiquinol can have an immune-strengthening effect.

What is Coenzyme Q10?

Coenzyme Q10 is a vitamin-like nutrient and the only fat soluble antioxidant that is produced naturally in the body. As an essential part of the body’s intracellular respiratory chain, the coenzyme is vital for energy production in the mitochondria. It plays an essential role in electron transport during oxidative phosphorylation and, thus, in mitochondrial production of ATP — the energy in each of our cells and all of our life processes. Almost all (96%) of aerobically generated energy is produced by Q10.

Organs such as the heart and muscles, which use a lot of energy, depend on a sufficient supply of Q10 and produce less energy and strength if they are lacking Q10.

Moreover, coenzyme Q10 provides protection against free radicals. It is the most important fat-soluble antioxidant in the body besides vitamin E. Q10 should not be compared with the multitude of water-soluble antioxidants, which move freely in the blood and have rather non-specific effects. Along with vitamin E, Q10 has the special task of protecting the very sensitive cell membranes and this gives it a unique position amongst all antioxidants.

Analyzing

Cranberry

Proanthocyanidin - by Dr. Jacinthe Côté

Conferences at the Lallemand booth at Vitafoods: May 22nd @ 16h30 and May 23rd @ 14h30 9 The challenges of analyzing proanthocyanidins 9 Quantification and the importance of choosing the right standard 9 Methods based on proanthocyanidin depolarization – EuroCran 9 Methods based on gravimetric separation – BL-DMAC

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sports nutrition

Ubiquinol: A Highly Bioactive Form Studies have shown that the reduced form of Q10, namely ubiquinol, is much more bioavailable than Q10, which allows very high plasma levels to be achieved (Figure 1).1,2 This active version of the coenzyme does not have to be transformed by the body before use and thus has much higher bioavailability than its precursor. Until recently, it was impossible to use ubiquinol in supplements or functional foods; it reacts strongly with oxygen as soon as it is exposed to air and degrades back into coenzyme Q10. However, using an innovative process, the Japanese company Kaneka has succeeded in developing a ubiquinol that is stable and suitable for use in supplements and functional foods without degradation.

Q10/Ubiquinol Levels in Athletes

Mcg of Coenzyme Q10 per mL of Plasma

Published scientific papers show that trained athletes often have lower Q10 plasma levels than untrained people.3 In addition, intense training and exercise leads to a decrease in Q10 plasma levels in athletes.4 It has also been shown that athletes have lower plasma levels during periods of heavy training than in training-free periods, such as during the winter.5 This may be caused by different mechanisms. Athletes appear to have a greater requirement for Q10, which is not fulfilled by normal food intake and biosynthesis in the body. Highly trained athletes can therefore have lower Q10 levels in their tissues and blood, and this can limit their performance. Thus, it is especially

8 Ubiquinol (QH) 1

7

Ubiquinone (oxidized CoQ10)2

6

important for athletes to monitor their Q10 plasma levels and to include supplements in their diet as necessary.

Better Performance, Less Fatigue Recent studies show a link between Q10 plasma levels and performance capacity: the higher the Q10 plasma level, the higher the performance capacity and the longer the time until fatigue is experienced.

These effects have been demonstrated in professional athletes. A Japanese study with kendo athletes proved that supplementation with coenzyme Q10 leads to a significant decrease in exercise-induced muscle tissue microinjuries.6 Results of another study showed that athletes were less exhausted after the ingestion of Q10 compared with a control group.7 Further possible effects that may prove to have valuable sports sector potential have already been shown in animal trials. An immune strengthening and virus suppressing effect was observed in a study with influenzainfected mice. As susceptibility to infections is one of the main issues for athletes, regular ubiquinol supplementation could be highly beneficial. Another mouse model showed a direct performance increasing effect, even after a single dose of ubiquinol.8 The researchers observed a “significant increase in the running time” of the supplemented group.

Human studies into these effects will follow.

For example, an ongoing study with trained elite athletes in Germany is investigating how athletes in particular can benefit from high Q10 plasma levels. Initial results are expected later this year.

5

Safe: No Doping

4 3 2 1

90 mg QH

300 mg Ubiquinone

150 mg QH

600 mg Ubiquinone

300 mg QH

0

Figure 1: A comparison of data from two separate studies.

Ubiquinol in Sport • Enhances performance • Reduces fatigue • Aids recovery: fewer muscle microinjuries • Strengthens the immune system • Protects against free radicals • Non-doping substance

www.nutraceuticalmag.com May/June 2012

Ubiquinol can be safely used in a large range of sports supplements and functional foods 900 for sportspeople — mg alone or as part of a Ubiquinone multicomponent system.

Combinations with vitamin E or with other antioxidants such as vitamin C are possible. According to the Deutsche Sporthochschule in Cologne, Germany, ubiquinol is not categorized as “doping.”

As such, it is part of the “Kölner Liste” of tested, doping-free substances.

References

1. K. Hosoe, et al., “Study on Safety and Bioavailability of Ubiquinol (Kaneka QH) After Single and 4-Week Multiple Oral Administration to Healthy Volunteers,” Regulatory Toxicology and Pharmacology 47, 19–28 (2007).

2. H. Ikematsu, et al., “Safety Assessment of Coenzyme Q10 (Kaneka Q10) in Healthy Subjects: A Double-Blind, Randomized, Placebo-Controlled Trial,” Regulatory Toxicology and Pharmacology 44, 212–218 (2006).

3. V. Wyss, et al., in G. Lenaz, et al. (Eds.), Highlights in Ubiquinone Research (Taylor and Francis, New York, New York, USA, 1990) pp 303–306.

4. G.P. Littarru, et al., “Metabolic and Diagnostic Implications of Blood CoQ10 Levels,” in K. Folkers, T. Yamagami and G.P. Littarru (Eds.), Biomedical and Clinical aspects of Coenzyme Q, Vol. 6 (Elsevier, Amsterdam, the Netherlands, 1991) pp 167–178.

5. G.P. Littarru, Energy and Defense (Casa Editre Scientifica Internazionale, Rome, Italy, 1994) p 84.

6. M. Kon, et al., “Reducing Exercise-Induced Muscular Injury in Kendo Athletes with Supplementation of Coenzyme Q10,” Br. J. Nutr. 100(4), 903–909 (2008).

7. K. Mizuno,et al., “Antifatigue Effects of Coenzyme Q10 During Physical Fatigue,” Nutrition 24(4), 293–299 (2008).

8. H. Maruoka, et al., “Effects of Exercise and Food Consumption on Plasma Oxidative Stress,” J. Phys. Ther. Sci. 24, 37–41 (2012).

For more information

Filip Van Hulle Sales and Marketing Manager Kaneka Pharma Europe, QOL Division Tel + 32 2 663 0348 Filip.VanHulle@kaneka.be www.kanekaQH.info/www.kanekaQ10.info

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Natural Obtained through a gentle aqueous extraction and standardized to proteinase inhibitor II (PI2), a protein naturally present in potatoes, Slendesta is a natural and safe ingredient associated with no side effects.

Science Human clinical studies with hundreds of participants have shown Slendesta to be beneficial in helping people meet their weight management goals.

slendesta.com Š Kemin Industries, Inc. and its group of companies 2012. All rights reserved. Ž™ Trademarks of Kemin Industries, Inc., U.S.A.

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market trends

Health and Wellness Trends in Scandinavia Euromonitor International highlights some of the current trends that are shaping the health and wellness landscape in the four key Nordic markets of Denmark, Norway, Sweden and Finland.

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lthough there are obvious similarities between the markets in the region, they are by no means totally homogenous when it comes to consumer preferences or regulatory environments.

In terms of total annual value sales, Sweden is Scandinavia’s biggest market for health and wellness foods and beverages, with sales amounting to almost €3.8 billion in 2010, although Norway, Finland and Denmark were not far behind. However, in terms of annual per capita spend, Norway stands out as the clear leader, with €655 in 2010, whereas Sweden came bottom with €407.

Denmark Launches the “Fat Tax”

The Danish government is known for being at the forefront of taking drastic regulatory action when it believes the nation’s health to be at stake. No doubt, many will remember the instance of 2004 when it forced breakfast cereal manufacturers to reformulate their products because the fortification levels of certain vitamins and minerals were considered to be potentially dangerous to the Danish population’s health. In 2011, chiefly motivated by the fear of spiralling obesity statistics, the Danish government introduced a “fat tax” on 1 October, which applies to foods that contain in excess of 2.3% saturated fat.

This includes snack foods, butter, milk, dairy products and meat, with not even the iconic Danish bacon being spared. The policy makers estimate that the measure will cut the consumption of saturated fat by around 10%. Whether this will translate into an actual slimming down of the Danish population and/or lead to a reduction in cardiovascular disease, only time will tell.

Fortified/Functional Product Acceptance is Divided

Owing to Denmark’s restrictive regulations in the area of food fortification, value sales of fortified/functional packaged foods and beverages are comparatively low. In line with the prohibitive regulatory environment, the prevailing consumer attitude towards fortified/ functional products is not too positive either — many view these products as “adulterated” or “synthetic” and generally inferior to their standard counterparts. Hence, there is a strong drive towards “natural” and organic foods in Denmark. In contrast, fortified/functional products have a long history in Finland, where innovations such as xylitolsweetened gum and cholesterol-lowering spreads were pioneered, before taking off on a global scale. Benecol cholesterol-lowering spread from Raisio Oyj, for example, was launched in Finland in the mid-1990s.

The ties between industry and research institutions are strong in Finland, and fortified/functional products are widely accepted by consumers as health promoting and reliable. This is reflected in

www.nutraceuticalmag.com May/June 2012

Euromonitor International’s health and wellness statistics, which show that fortified/functional foods and beverages accounted for slightly more than one third of total health and wellness sales in Finland in 2010, claiming around the same share as naturally healthy foods.

In Denmark, fortified/functional products accounted for just an 18% share, whereas naturally healthy and organic foods combined accounted for just over half of total Danish health and wellness sales.

Danish per capita spend on organics in 2010 was 10 times that of the Finnish spend.

Scandinavia, home to a number of major dairy players, such as Arla and Tine, has also long been a hotbed of dairy innovation, with interesting new launches appearing on a regular basis. And although launch activity has, admittedly, declined since the onset of the financial crisis, innovatively marketed products are still popping up in the region.

For instance, in 2011, Tine, Norway’s leading dairy company, launched YT Between Meals, a line of curd-based spoonable dairy products in pots with added berries, fibre and grains. Developed in collaboration with nutrition experts at the National Sports Centre, they are promoted as being high protein snacks that aid muscle growth and, because they release their energy content slowly, boost endurance. They are targeted at physically active people, especially gym goers, with the tagline “Perfect on your way to fitness.” The products are designed to be eaten before exercise and/or for consumption as a daily snack. For added convenience, a spoon is included in the packaging.

In Better for You, Keyhole is Key

The green Keyhole nutrition label, a voluntary labelling system designed to help consumers choose healthier foods, has been in operation in Sweden for more than two decades. In 2006, the scheme’s success gave rise to the Nordic Keyhole Project (NKP), a collaborative effort co-ordinated by the Nordic Council of Ministers (NCM, a pivotal forum of regional interstate communication), leading to the scheme’s implementation in Norway and Denmark in 2009.

Finland, although part of the NCM and an active NKP project partner, decided, for the time being, not to participate in the rollout because it employs an equivalent label, the “Heart.” To qualify for the Keyhole symbol, which can be used on packaged foods as well as meals sold through consumer foodservice outlets, foods must meet a number of criteria; they must not exceed set levels of fat, sugar, salt and contain a minimum amount of dietary fibre, when applicable. The exact requirements vary according to the food category, of which there are 25 in the scheme.

In practice, the Keyhole symbol is found on many better-for-you (BFY) products, denoting choices that are lower in salt, sugar and fat

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and higher in fibre than their standard equivalents. However, products that contain artificial sweeteners are not permitted to use the Keyhole symbol, which presents a major drawback for the makers of BFY reduced-sugar beverages. The Keyhole symbol is well recognized

by Scandinavian consumers. A recent survey conducted by the Norwegian Department of Health Affairs, for instance, found that some 82% of Norwegians were aware of the symbol, with 69% of consumers perceiving the Keyhole as making the purchase of healthy products easier and 71% stating that it played an important role in their food purchase decision making. During trade interviews in Norway, many respondents said that they considered brands lacking the Keyhole symbol as not being “real” BFY products. Norwegian food giant Orkla Group launched a range of BFY products in 2011, including several sporting the Keyhole symbol, for example low-in-salt Pastella wholegrain fettuccine and Grandiosa pizza with a low salt and fat content, plus wholegrain for added fibre.

has sent consumers flocking to discounters and private label offerings.

And yet, health remains of key importance for Danish consumers. Hot cereals, which consists almost entirely of natural, no-added-sugar oatmeal products often eaten with fresh cold milk and strained raisins, enjoyed the most dynamic value growth during the 2006–2011 review period. This traditional Danish breakfast cereal is clearly experiencing a huge renaissance. In Sweden and Norway, where muesli is regarded as the healthiest type of breakfast cereal, the category outperformed all other breakfast cereal categories in terms of value growth during the 2006–2011 review period.

In Finland, in family breakfast cereals, muesli is holding on to its position as the most popular, and is predicted to retain its retail volume share of 52% in 2011. Healthy nutritional content and weight

BFY Category Faces Challenges

Overall, BFY products registered a positive growth performance in the four Scandinavian markets researched by Euromonitor International during the 2005–2010 review period, but owing to category maturity and trends towards “more natural” foods, hopes for sustained future category growth are somewhat limited. A case in point is Sweden, the market in which BFY products registered the most sluggish CAGR (a mere 1%), characterized by a marked decline in BFY food and beverages uptake in the second half of the review period. Value sales of BFY beverages contracted by 30% between 2007 and 2010, and those of BFY packaged food by 8%. The main reason behind this lacklustre performance is the growing popularity of the ‘Low Carbohydrate High Fat’ (LCHF) diet trend, popularized by opinion leaders in the health and wellness field, such as blogging celebrity physician, Annika Dahlias. Contrary to what one might expect, the LCHF trend has not benefited sales of BFY reduced-sugar soft drinks as these usually contain artificial sweeteners, which have been much maligned in the Swedish press. Instead, Swedish consumers have gravitated towards natural foods … and the organic category has enjoyed fairly buoyant growth. In Denmark, BFY reduced-fat dairy products plummeted in both volume and value terms, also because consumers started to switch to organic products instead. In BFY packaged food in 2010, reduced-sugar bakery products delivered the most dynamic performance, driven by avid discussions about sugar’s negative impact on health in the Danish media. Reduced-sugar breakfast cereals registered the highest growth rate of 4% in 2010.

However, the introduction of the “fat tax” in 2011 might serve to spark off renewed growth in the BFY reduced-fat category in the coming years.

Drive Towards Healthy Breakfast Cereals

There is a marked movement towards healthier breakfasts across Scandinavia. As mentioned, health-conscious Danes are homing in on natural products made from whole grains with a low-sugar content.

These changing consumer preferences are manifesting themselves in a shift towards muesli and hot cereals. They also offer the lowest unit prices, equating to best value for money, a factor increasingly important across the region owing to the changing economic climate.

The strong substitution trend towards muesli and hot cereals in Denmark dates back to 2004; but, up until 2008, premium branded and organic products drove these two dynamic categories. Since then, precipitated by the onset of the recession, the value-for-money trend

www.nutraceuticalmag.com May/June 2012

management are key points of focus among manufacturers and consumers alike. This was the case across all categories, except children’s breakfast cereals, which, up to 2011, had only witnessed a few health positioned new product launches, such as Kellogg’s Rice Krispies Multi Grain from Nordisk Kellogg’s Finland. However, with regard to products targeted at adult consumers, the trend for low carbohydrate dieting, which is not just confined to Sweden, has made some consumers of RTE cereals look for non-carbohydrate alternatives for breakfast. This could threaten the breakfast cereals category in the future, including muesli.

Outlook: Sluggish

Euromonitor International predicts that health and wellness food and beverage sales in the four key Scandinavian markets will be fairly flat during the forecast period, with CAGRs expected to range between 1–2%. This will not be due to falling interest in health and wellness, but be down to a drive towards value-for-money offerings, including private label products. The migration towards organic products is likely to continue, so fairly dynamic growth in this category, particularly in Finland and Sweden, is still expected. In Norway, the highest value growth is predicted to come from the emerging food intolerance category, led by lactose-free and gluten-free foods.

For more information

Ewa Hudson Head of Health and Wellness Research Euromonitor International Tel. +44 207 251 8024 ewa.hudson@euromonitor.com www.euromonitor.com

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A Prescription for Lower Carbon Healthcare A combination of drivers related to regulation, efficiency and reputation has encouraged many organizations to look at how they can measure and reduce carbon in their own businesses.

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owever, the agenda is now shifting towards the wider carbon impact of the company. There is an increasing awareness that carbon emissions outside the direct organizational control represent an opportunity to improve efficiencies and reduce emissions.

In the healthcare sector, this could apply to the carbon embodied in a particular ingredient used to make a finished product, how chemical waste is disposed of by a supplier or the release of greenhouse gases contained, for example, in the propellant of an inhaler used by patients.

This is important because the NHS, which represents approximately 25% of England’s public sector emissions, estimates that 60% of the emissions can be allocated to procurement. Healthcare companies recognize that significant savings could be made in their indirect emissions and there is increasing pressure for them to demonstrate this to their customers. There are however certain challenges to overcome: Product development: A new drug or finished product can take many years to develop, from initial R&D through to approval by regulatory bodies. It is very difficult to then change the components, packaging and delivery model of such products because it can require expensive retesting and new regulatory approval. This contrasts with the retail sector wherein product specifications can change within days in response to a new low carbon innovation. The challenge for companies, therefore, is to design the carbon and associated cost out of products during the initial R&D phase.

Patent system: When a pharmaceutical company is granted a patent for a new drug, it is important that that product reaches the market quickly to meet the needs of patients, to recover the costs involved in the R&D phase and to maximize the patent lifetime. The urgency to bring the drug to market means that it may not necessarily be made as efficiently as possible Relationship with suppliers: Companies with fast moving consumer goods and high volume sales are more able to quickly use different raw materials and suppliers to reduce emissions. In contrast, this is more difficult for healthcare companies because of the specific and complex chemical processes and more limited number of suppliers who produce the active ingredients. This makes collaboration with these suppliers more important if reductions are to be achieved across the supply chain.

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Supply chain characteristics: The large number of chemical components that are often used to produce a dosage form introduces another challenge for healthcare companies. The process becomes more complicated at the very start of the supply chain, which makes it more challenging to obtain detailed information on carbon impacts.

Packaging: Drugs and nutraceutical products are packaged to meet regulatory requirements, which may not be the most carbon efficient design. Given these regulations, it can be challenging to implement innovative designs that save carbon.

With this in mind, how can pharmaceutical, nutraceutical and healthcare companies respond?

Production techniques: The production of many drugs can be expensive and requires complicated chemical processes that generate significant amounts of waste.

Optimizing the production process to increase yield and minimize waste will increase profits and save carbon.

Product use phase: GlaxoSmithKline revealed in its 2010 Sustainability Report that an estimated 40% of its overall carbon footprint comes from indirect emissions resulting from the use phase of its products, such as propellants in inhalers. This shows that the use and disposal of pharmaceutical products can make significant impacts on emission reductions.

Collaboration: The industry is looking at more collaborative approaches to sourcing and refining raw materials. Whereas individually, companies may procure a chemical ingredient at a lower volume than other industries, a collective approach to encourage suppliers to adopt less carbon

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intensive processes can help bring about change. Collaboration might also be an effective approach to tackle the regulatory red tape encountered when changing a product to a lower carbon design.

Expert help: The assessment of reducing carbon across a value chain can be complex. It is important that the assessment meets the aims of the company and adds value. Concerned companies should start evaluating this area now and seek expert guidance. For example, new technology and processes such as RFID tagging, the use of two-dimensional barcodes and new packaging techniques can all help to optimize stock control, reduce wastage and improve logistics. As well as generating cost savings, these developments should also have a positive impact on the environmental footprint of healthcare and pharmaceutical products.

As discussed, the unique business model and nature of the healthcare industry mean that this is one of the most complex sectors for measuring, managing and reducing carbon emissions. However, as customer expectations increase, working to reduce the carbon impact of their products is an area in which forward-thinking companies can genuinely differentiate their brand and products from the competition.

For more information

Dr Paul Taylor is an experienced sustainability consultant who has provided technical leadership to value chain footprinting across a wide range of sectors. The Carbon Trust Advisory helps large businesses to harness opportunities and manage risks in the move to a green economy. Its paid-for professional services include strategic business advice, carbon footprinting, new product/service design and value chain decarbonization (www.carbontrust.com).

Visit us at Vitafoods Stand 1443

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Prostate Health Cocktail: Not Your Average Vitamins!

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o many people, the idea of using an over-the-counter supplement to treat prostate cancer is laughable. The American Cancer Society warns against such a practice, stating that such alternative treatments are rarely shown to have any clinical efficacy and may do more harm than good. However, a number of currently active clinical trials are exploring the benefits of dietary supplements to prostate cancer patients. Data from these trials may drastically change public opinion on the merits of such treatments. Armed with clinical evidence of efficacy, safety and minimal side-effects, these dietary supplements may have the potential to infiltrate the prostate cancer treatment algorithm.

The dietary supplement Prostate Health Cocktail (PHC) has the potential to become an alternative option to androgen deprivation therapy (ADT) for men with recurrent prostate cancer. PHC is produced by OncoNatural Solutions, Inc., and is a combination of nutrients, minerals, herbs and vitamins.

According to the company, each ingredient in PHC was independently shown to prevent prostate cancer development, kill prostate cancer cells or improve the symptoms of benign prostate cancer enlargement. By enrolling patients in an FDA approved Phase II clinical trial studying the effects of PHC on prostate serum antigen (PSA) levels, the company is taking a critical step to foster the credibility of its product. The repute of PHC is also boosted by the reputation of its developer, Dr Jacek Pinski, MD, PhD. His experience as codirector of the Prostate Cancer Research Program at the University of Southern California (USC) Norris Comprehensive Cancer Center and Hospital (which has no stake in the company, but is sponsoring the clinical trial) will certainly help to strengthen the perception of legitimacy that PHC needs to be considered as a valid treatment option. Although safety data has not yet been reported, it is highly unlikely that

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PHC will have severe side-effects as all of its ingredients are already available as over-thecounter dietary supplements. According to OncoNatural’s website, ingredients in the PHC cocktail include epigallocatechin (green tea), lycopene, saw palmetto, genistein, selenium, and vitamins D and E. According to a 9 April 2012 press release, preliminary data showed that PHC stabilized the PSA levels in 83% of men who had previously undergone radiotherapy or radical prostatectomy. The single-arm study examined whether treatment with PHC alone (3 times daily) could stop PSA levels from increasing in men whose PSA levels continued to go up following localized treatment. In general, stabilization of PSA levels is not as clinically reliable as improvement in overall survival. However, since increasing PSA levels are often correlated with disease progression, the FDA still considers it to be a valid endpoint representing clinical benefit in Phase II trials.

With only 28 participants enrolled, the current trial is quite small, which will limit the reliability of the final data. However, the well-defined study design helped to compensate for the small sample size. The study criteria included stipulations on the duration between initial cancer treatment(s) and the start of PHC treatment, the types of previous treatments that were allowed, the staging of the disease, and the initial PSA levels and doubling time.

There is currently no curative option for men with prostate cancer once surgery and/or radiotherapy have failed. ADT, while overwhelmingly the treatment of choice for this stage of prostate cancer, is far from perfect. It is costly, has a number of unpleasant side-effects and, with time, prostate cancers become androgenindependent, which renders ADT useless.

GlobalData spoke with a representative from OncoNatural Solutions who maintains that PHC is not designed to replace current treatments. But the reality is that the weaknesses of ADT provide ample room in

the market for another palliative treatment such as PHC that is cost effective and likely to be free from harmful side-effects. It remains to be seen whether PHC can extend the overall survival of patients compared with ADT. The representative could not confirm to GlobalData if OncoNatural Solutions was interested in launching any additional studies.

However, we believe that if the current trial continues to be successful (as these results are preliminary), a Phase III clinical trial with a primary endpoint of increased overall survival is on the horizon. If such data were positive, it would easily position PHC to encroach on the market share currently dominated by AstraZeneca’s Zoladex and Casodex, and Abbott’s Lupron.

Even if future trial results for PHC are positive, it will not be easy for OncoNatural to successfully market an OTC “nutraceutical” such as PHC as a treatment option for a life-threatening disease. PHC must first shed the inevitable stigma that dietary supplements are significantly less effective than pharmaceuticals for treating serious, complex diseases such as cancer. This will not be an easy task; studies have long suggested the benefits of taking vitamins and minerals for the prevention of various diseases, but nutraceuticals are yet to claim solid ground in the treatment regimen of a high-stakes ailment like cancer. However, with enough valid clinical evidence and a market hungry for inexpensive new solutions, GlobalData believes supplements such as PHC are capable of changing the minds of both clinicians and consumers.

For more information

Dr Cheryl Strelko Oncology and Infectious Diseases Analyst GlobalData Tel. +44 1204 543 537 pr@globaldata.com www.globaldata.com

3-5 October 2012

Jakarta International Expo, Kemayoran, Jakarta, Indonesia

Access to a population of

BOOK YOUR STAND

The only dedicated food ingredients exhibition in the ASEAN region After record-breaking shows in Indonesia and Thailand, Fi Asia is returning to Jakarta in 2012 to bring the industry together once again. With high quality products and a growing consumer market, Southeast Asia is now the destination for the industry's key players.

Huge market to feed - Indonesia is the world’s 4th most populated country with a food processing industry serving 255 million people Significant exposure - Fi Asia 2010 in Indonesia was attended by over 7,700 food professionals from all over the world Presence alongside market leaders - Fi Asia exhibition attracts major players such as Firmenich, Kraft International, CP Kelco, DSM, Brenntag, Fortitech and BASF to name but a few. Showcase your products alongside theirs to set your stall out in the industry.

For more information or to book a stand: UBM Live Tel: +31 2040 99544 Email: FiAsia@ubm.com

UBM Asia (Thailand) Tel: +66 2 642 6911 Email: Nongnaphat.J@ubm.com

www.ingredientsnetwork.com/Asia-Indonesia

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technology

Recent Advances in the Analysis of Stevia Leaf Extracts

As the functional food industry continues its push to find suitable alternatives to high calorie sweeteners, new analytical detection techniques are being brought to the forefront.

T

raditional natural sweeteners such as sucrose have a relatively low potency and, therefore, require large quantities to be added to the food and beverage products to obtain the desired taste.

As the industry moved to artificial sweeteners, the potency increased and, therefore, the relative amount added decreased. This trend continued with stevia and its primary component, rebaudioside A, which is more than 200 times sweeter than sucrose. Now, as manufacturers strive to produce consistently safe products, traditional analytical techniques are often lacking the sensitivity to meet their needs. In the beverage industry, the use of high pressure liquid chromatography (HPLC) with UV detection has been common practice for decades. However, the chemical structure of rebaudioside A (reb A) and the other compounds extracted from stevia lack a strong UV chromophore, so this analytical approach lacks sensitivity. In 2005, a new HPLC-based universal approach was introduced called charged aerosol detection (CAD). This nebulization-based detection technique measures the charge applied to non-volatile analyte particles, and has sub-nanogram on-column sensitivity. This detection technique was first published for the analysis of stevia extracts by the CocaCola Company in 2008.1 Since that time, several alternative analytical methods have been developed and published. This article focuses in on two newly developed solutions that meet the analytical requirements of the industry.

formate rather than phosphate or phosphoric acid is employed, which adds flexibility to the analytical method. The CAD method is sensitive, with limits of quantification (LOQs) of 2.3 µg/mL by CAD, compared

“The structural likenesses of extracted compounds make chromatographic separations challenging.” with 7.0 µg/mL by UV-210 nm absorbance for reb A. Retention time variability between mobile phase batches was within 1.3% for rebaudioside A, indicating that the method is rugged and reproducible.

Reversed Phase Technique

The ability to monitor the production process and test the final

Trimodal HILIC Technique

The first challenge for the manufacturer occurs during the isolation and purification of the desired sweetener — typically reb A from raw plant material. As many of the extracted compounds are quite similar, their structural likenesses make chromatographic separations challenging. Several current compendia methods (JECFA, USP) rely on hydrophobic interaction liquid chromatography (HILIC) separations on amino phase columns that are often time consuming and have a reputation for retention time instability for individual steviol glycosides. By modifying the methods to use HILIC conditions with the Thermo Scientific Acclaim Trinity P1 column — a trimode column with anion exchange, cation exchange and reversed phase functionality — multiple compounds, including reb A and related impurities, are consistently separated.

Charged aerosol detection can be used when a volatile mobile phase of ammonium

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20 min

8.5 min Column: Acclaim RS:C Polar Advantage II 2.2µ 2.1 x 250 mm Column Temperature: 40 ˚C Injection Volume: 5 µC L Mobile PhaseA: Deionized Water (DI) + 0.1% Formic Acid Mobile PhaseB: Acetonitrile + 0.1% Formic Acid Figure 1: A comparison of data from two separate studies.

Flow Rate: 0.7 mL/min Gradient 5 to 60% B in 9 minutes hold 1 and return Total Run Time: 16 minutes

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improvements noticed on the UHPLC method. This level of sensitivity is more than tenfold lower than the observed LOQ with UV at 210 nm for this particular analytical method. Both the HILIC method and the RP method were discussed in more detail in a recent webinar.2

Conclusion

product both for uniformity and stability is another challenge. The most common technique used in liquid chromatography is the use of reversed phase with a non-polar stationary phase (typically using C18 chain lengths) and materials eluted according to their hydrophobicity (from polar to non-polar). This technique has seen significant expansion during the past decade with smaller particle size columns and the development of UHPLC systems that are able to handle the increased backpressure resulting from these columns. UHPLC columns were recently used for the analysis of steviol glycosides in beverages (as discussed below). A 2.1 x 250 mm Thermo Scientific Acclaim RSLC Polar Advantage II column with a particle size of 2.2 µm and a simple gradient from 95% DI water with 0.1% trifluoroacetic acid (TFA) to 60% acetonitrile + 0.1% TFA in 9 minutes was performed. The total method time for the analysis was reduced by a factor of three (approximately) while increasing resolution of the reb A by more than 20% by changing to the small particle size from 5 µm (Figure 1). The LOQ is <10 ng on column for both the HPLC and UHPLC method with additional

Because the sweetness and potential aftertaste of the different compounds in stevia leaf extracts is very important, many companies must ensure that their products are produced consistently using a viable analytical method. Charged aerosol detection has great applicability throughout the manufacturing process to ensure that product quality and consistency remains uniform. The charged aerosol detector’s universality and enhanced sensitivity compared with UV detection allows additional components from stevia to be detected in foods and beverages.

References

1. J.F. Clos, et al., “Photostability of Rebaudioside A and Stevioside in Beverages,” J. Agric. Food Chem. 56(18), 8507–8513 (2008).

2. From Saccharin to Stevia — Advances in Sweetener Analysis, www.dionex. com/en-us/events/webinars/lp-111091.html (September 2011).

For more information

Christopher Crafts, Deanna Hurum, Jeffery Rohrer and Ian Acworth Chromatography and Mass Spectrometry Division, Thermo Fisher Scientific (www.thermofisher.com)

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Innovate to Survive Innovation is the lifeblood of any organization; it helps us to discover new ways of working, improve products or technologies and, in a business context, to stay ahead of the competition.

I

n particular, it is crucial for the nutraceutical, raw materials and functional food and drink ingredients industries wherein companies are constantly looking to find the next breakthrough ingredient. For this year’s Vitafoods Europe, we’re focusing heavily on the role that innovation plays throughout the event. At our scientific conference, Dr Jason Halford from the University of Liverpool will discuss The SATIN (Satiety Innovation) Project — Generating Novel Food Structures to aid consumer weight management. The industry has yet to develop a lasting range of commercially viable satiety enhancing foods that are acceptable to the consumer. Subtle changes to the microstructure of food can enhance satiety signals that arise along the length of the GI tract. The SATIN project uses in vitro modelling and novel food processing technologies to combine novel structures and functional ingredients to develop commercially viable satiety enhancing products.

In addition, Dr John Stewart, Open Innovation Manager at Tate & Lyle plc, who will be chairing the sessions on digestive health at the conference, cites the practice of Open Innovation as commonplace in nonfood sectors such as IT, communications and Big Pharma. Open Innovation is a practice in which different industries, companies and teams use an extensive array of approaches, depending on their structure and stage of adoption. Many tools are familiar, such as technology scouting and licensing, venture

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investing, participation in research consortia, supplier ‘challenge days,’ online portals and the use of intermediaries. Dr Stewart stresses that more food ingredient companies, large and small, must learn the value of Open Innovation and accept this as the norm.

At Tate & Lyle, Dr Stewart has dedicated a team to manage ‘Open Innovation.’ As well as scouting new technologies, the team of ‘intrapreneurs’ creates an easy access route for smaller partners to work with the company. A recent example from this is SODA-LO, an innovative, clean label salt product that enables sodium reduction in food without loss of flavour. Eminate Ltd (a University of Nottingham subsidiary) created the technology but, with limited resources, took the ingredient as far as it could go without partnering with a global player. The collaboration with Tate & Lyle will see SODALO being developed further to reach new customers and markets.

At Vitafoods Europe, we’re not just embracing innovation as part of our conference. This year’s New Products Zone provides all attendees with inspiration for new ingredients within the exhibition.

More than 150 new products from leading manufacturers will make up the New Products Zone and contain many ingredients that visitors have never seen before. Products include CaloriSorb from Aenova Holding GmbH, which reduces fat absorption for weight management; BONOLIVE from

BioActor, the only bone health ingredient from olive polyphenols; Mucosave from Bionap Srl, the first ingredient specifically created for mucosal protection, and Lactobacillus casei 431, a probiotic chewable tablet from Chr. Hansen A/S. Finished Products Expo, which is colocated with Vitafoods Europe, will have its own New Products Zone at its entrance where the latest functional foods, drinks and dietary supplements launched in the last 12 months will be on display. Products will include Novisyn from Fulcrum Health Limited, which is a pure, oral form of Hyaluronan; HHIce Cream Probiotic Defense from NEWtritious, a soft-serve frozen yoghurt mix that supports immune function and Nature’s Plus Sugar Armor from Nature’s Plus, which blocks up to 50% of sugar and starch absorption per meal to increase weight loss.

But it’s not just the products on display at this year’s show that will make a mark on the industry. In the past 15 years since Vitafoods was first launched, there has been a great wealth of innovation, which has essentially transformed the face of the functional food, drink and dietary supplement industry. In particular, the antioxidant category, one of the largest markets for nutraceuticals, has evolved hugely, offering great opportunities for functional food and dietary supplement applications. We’ve also noticed an increase in prominence of fatty acids such as CLA and omega-3, -6 and -9, which have become increasingly important in both of these sectors during the past few years too. Functional ingredients from the sea have also served the dietary supplement and functional food market well during this time, particularly the likes of algae, astaxanthin and krill, whereas herbs and botanicals have become integral to functional food and beverage development.

However, whilst our exhibitors are doing all they can to ensure that their offering is as cutting-edge as it possibly can be, we’re acutely aware that the show itself needs to reflect their efforts. As a result, during the last few years we have focused a great deal of effort on ensuring that the show is as innovative as possible. We’ve also extended

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this commitment to the rest of the Vitafoods portfolio too. South America is set to be a key player during the next decade, which is why we staged our first Vitafoods South America event in Brazil in March. There is also a growing market for dietary supplements in Asia, so we are launching a Finished Products feature zone there in September to cater to this demand. I really believe that organizations that harness innovation can create a competitive advantage and I look forward to seeing and hearing all about the latest creative concepts from the nutraceuticals, raw materials and functional food and drink ingredients companies in Geneva from 22–24 May 2012.

Chris Lee

Launch of Vitafoods Asia a Great Success The debut of Vitafoods Asia proved to be a hit with exhibitors and visitors alike when it launched in Hong Kong in September 2011.

With more than 2150 attendees from over 40 different countries, including Australia, Malaysia, China, Japan, Thailand, Vietnam and Cambodia, making their way through the doors during the course of the three-day event, the nutraceuticals, functional food and drink ingredients show really exceeded targets. Asia Pacific is the second biggest global market for functional foods behind the USA, with a market value expected to reach $48 million in 2012. Speaking of the show’s success, Event Director Chris Lee commented: “We’re delighted that the event was received so well; it just goes to show that the market for panAsian nutraceutical, functional foods and functional drinks ingredients is very strong. Plans are already well under way for next year’s show and we’re now planning the strategy to give even more value through education and innovation for visitors and exhibitors to Vitafoods Asia 2012.” More than 125 exhibitors showcased their innovative products, including international brands such as BASF, Chr Hansen, DSM, Ingredia, Naturex, Danisco and LycoRed, plus regional companies such as Yigeda Bio-Technology, Shaanxi Jiahe Phytocham, Handan Chen’Guang Precious Oil and Huisong Pharmaceuticals.

For more information Chris Lee Portfolio Director at Vitafoods www.vitafoods.eu.com

www.nutraceuticalmag.com May/June 2012

A spokesperson from Chr Hansen, said: “We are very satisfied with the event and never expected to have had so many good visitors from South East Asia.” Popular visitor attractions included the Seminar Theatre with a host of exhibitors presenting sessions on some of their latest research, nutraceutical and functional food and drink innovations. Keynotes from Daniel Quek, President of HSIAS and Chairman of AAHSA on Regulatory Harmonization in ASEAN and Katrina Diamonon, Consumer Insight Analyst at Datamonitor on functional food trends in Asia were particularly well received. Other features that welcomed a high number of visitors included the EAS free one-on-one advisory sessions and the New Products Zone, which showcased innovative new market launches from the last 12 months.

Innova Market Insights also explained the latest trends and business opportunities for companies across Asia in VitaTrend.

Professor Yang, of the Chinese Nutrition Society, commented: “I congratulate Vitafoods Asia for its milestone in creating a huge opportunity to facilitate the growth of the functional foods industry in Asia. Like all other nutritionists in the industry, we are confident that the show will become a significant platform for exchange of ideas and information, thereby delivering innovative products and enhanced health services for the masses.”

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• Meet over 150 international ingredients and raw materials suppliers • See the New Products Zone featuring over 75 of the latest innovations • Attend over 25 free seminars • Learn about market and trend forecasts from Vitatrend • Hear free keynote presentations • Receive free Regulatory Advice from EAS • Find new products to distribute in the Finished Products Zone • Gain market insights from Mintel • Debate the issues at the Vitafoods Asia Discussion Forum Supported by

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Register today at www.vitafoodsasia.com/nbt

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industry issues

Changing the Pill Paradigm Consumers, no longer just those who support the natural and organic cause, are becoming more informed and critical about the food they eat.

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aving functional benefits from a whole food ingredient can add value and maintain a clean label, which makes it all the more appealing to the informed consumer. Plus, it also has the added benefit of extending an existing product line into a new demographic.

www.nutraceuticalmag.com May/June 2012

The current trend of using a well-known food mixed with something more exotic, such as chia seeds in apple sauce, can peak consumer interest and tempt them to try new functional foods. This strategy should extend far beyond the standard bar and cereal categories that are currently driving this change. Ingredients offered by BI, for example, such as chia, quinoa and baobab fruit, which have been eaten for centuries in their indigenous nations, not only add functionality, but also have added marketing value because of the unique stories behind these ingredients.

Even though the current consumer is well informed and willing to try new functional foods, they are still looking for convenience, especially when it comes to functional beverages. For example, the “shot platform” has been wonderfully successful in the energy market and somewhat successful in pro- and prebiotic solutions. But, the food and beverage industries continue to be focused on providing discreet attributes to singular products. Yet, neither market is driving the long ball play, which provides the functional load benefit of a pill or a tablet in a food source.

Compliance is the number one issue in the nutrascience industry, just as it is in the world of Big Pharma.

Consumers never finish a total dosage course: taking a pill, having to remember to take a pill, having to swallow a pill, is truly tedious; the vast majority of consumers don’t like this process. Being able to get the efficacy benefit in the normal choreography of eating is a far better approach. The food and

beverage industry has the retail footprint, the geographic scale and the R&D dollar budget to totally disrupt this market. But, as yet, I have not seen the focus or drive to do so. It is a challenge to engineer a 500 mg efficacy load into a food delivery vehicle, given the taste, stability and shelf-life metrics that must be overcome; but, I believe the company that can remove a few femtoseconds out of today’s digital consumers by providing a functional, preventive tasty attribute will redefine the nutrascience market and dominate the health and wellness landscape.

The consumer is looking for an innovation platform of wellness, focused on health and prevention that provides safe, efficacious solutions across their buy responsibility. From the mother feeding a family, to the millennium driving a career, to a boomer living an active lifestyle, all are beginning to recognize the value of complexity reduction. By reducing the complexity of health and wellness, a company’s food/beverage product platform could, would and should provide a single point solution.

Marketing a company’s breakfast, lunch snack and dinner line as a homogenous wellness programme, all designed to complement each other in a complete value proposition, may eliminate the confusion consumers have concerning what is good and what is hype. We, as an industry, are behind the mindshare curve. When trusted advisers are social media or sponsor-driven pseudo experts, we allow others to frame our market, which negatively affects operational efficiency, time-to-market deployments and fulfilment lead times. Changing the market and disrupting an industry requires a commitment beyond just R&D. One must have a synergistic approach on digital strategy, a wellness focus and components to address that focus, all bound into a co-ordinated innovative product set. Asking a consumer to press the “like button” will not get us there.

For more information George Pontiakos President and CEO BI Nutraceuticals gpontiakos@botanicals.com www.botanicals.com

Bioavailability is a serious business.

Polyphenols can do a lot of good. But often the problem is getting them where they’re needed, because they suffer degradation in water and find it hard to cross the lipid-rich membrane of the gastrointestinal system. Which is why Indena invented the Phytosome® solution. In a Phytosome®, poorly soluble bioactives are formulated into soy lecithin. This disguises them as lipids, protecting them from water degradation and shuttling them across the phospholipid membranes. In this way, a Phytosome® mimics the dietary intake of these bioactives and improves their bioavailability. To know more about the active principles formulated by Indena as Phytosome®, visit www.indena.com or contact Indena today.

www.indena.com Headquarters: Indena S.p.A. Viale Ortles, 12 – 20139 Milan Italy tel. +39.02.57496 Indena Biotechnology (Shanghai) Co., Ltd - Unit 03, 16/F, Cross Tower, 318 Fu Zhou Road - Shanghai 200001 - China tel. +86.21.22815900 Indena France S.A.S. - 23, Rue de Madrid - 75008 Paris - France - tel. +33 1 45229128 Indena Japan Co., Ltd. - KDDI Bdl. 21F. 1- 8-1 Otemachi- Chyoda-Ku Tokyo 100-0004 - Japan - tel. +81.3.3243 9924 Indena USA Inc. - Two Union Square, 601 Union Street, Suite 330 - Seattle WA 98101- USA - tel. +1.206.340.6140

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Omega-3 Phospholipid EPA & DHA are important building blocks for healthy cell membranes. The ratio of EPA & DHA to other fatty acids in the membrane is called the Omega-3 Index – a strong indicator of cardiovascular health. In a recent human study, Superba™ Krill Phospholipid EPA & DHA had a significantly improved Omega-3 index compared to ordinary fish oil.

AkerBioMarine is the only krill harvester that has been awarded the prestigious Marine Stewardship Council certification for its eco-friendly harvesting and traceability from sea to shelf.

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