Extracellular Matrix Products
MicroMatrix® Dermal Repair Powder
Urinary Bladder Matrix [UBM] Technology
Keywords
■ MicroMatrix®
■ Chronic Wounds
This Masterclass guide is a concise overview aimed at exploring the use of a clinically advanced product called MicroMatrix® Dermal Repair Powder in wound management solutions and how to incorporate this into your practice.
What is MicroMatrix®?
■ MicroMatrix® Dermal Repair Powder stems from the Urinary Bladder Matrix (UBM) technology. It is a sterile, porcine-derived, lyophilized naturally occurring extracellular matrix (ECM) in particle form that facilitates the management of complex wounds.
■ Integra's UBM technology is an ECM scaffold that supports a transition of the host immune response from a scarring- type response to a remodeling response that facilitates deposition of vascularized, siteappropriate tissue, tissue that closely resembles the original tissue, both structurally and functionally1,2
■ MicroMatrix® Dermal Repair Powder has been associated with a modified inflammatory response: it provides an environment where the body is more likely to exhibit a higher ratio of M2 (pro-remodeling) to M1 (proinflammatory) macrophages, which may “kick-start” wound healing1,2,4.
■ MicroMatrix® Dermal Repair Powder is easy to apply and provides intimate contact with the wound bed. It is particularly relevant in irregular wounds, where it helps address challenging contours and geometries (uneven, tunneling, and undermined areas). It may be used as a powder or as a paste when mixed with saline solution, with no need to staple or suture.
■ MicroMatrix® Dermal Repair Powder is appropriate for acute wounds and chronic wounds and may be used alone or concomitantly with other collagen-based dermal matrices.
■ Temporary Scaffold
■ Wound Healing
■ Acute Wounds
■ Kick - start effect
■ Extra-Cellular Matrix Technology
■ Wound Reconstruction
How does MicroMatrix® work?
MicroMatrix® Dermal Repair Powder supports wound healing and tissue deposition by providing a temporary collagen scaffold that facilitates cellular infiltration, supports angiogenesis1,4,5,6 and modulates inflammation1,2,3 .
Micromatrix®:
■ Provides a Structural Scaffold: MicroMatrix® Dermal Repair Powder stems from porcine UBM Technology, which is rich in collagen – a key structural protein in the human body. When applied to a wound, this three-dimensional scaffold acts as a temporary framework where cells can adhere, migrate, and proliferate supporting the deposition of new tissue1,4,5,6
■ Features a collagen-based structure that supports the body's wound healing process and the deposition of site-appropriate tissue, with function and structure similar to normal tissue1,7-12.
■ Modulates the Inflammatory Response: the host response to MicroMatrix® Dermal Repair Powder has been shown to quickly transition from an initial pro-inflammatory response toward a more pro-remodeling immune response1,2.
■ Facilitates Cellular Proliferation and extracellular matrix Deposition: the presence of MicroMatrix® Dermal Repair Powder supports the proliferation of cells and production of new extracellular matrix (ECM) proteins1,3,13
■ Provides a Site for Vascular Ingrowth: the collagen scaffold allows for the migration and attachment of endothelial cells into the scaffold necessary for the formation of new capillaries, and integration into the existing blood supply1,3,13
Figure 1: MicroMatrix®
Figure 2: Clinical Wounds Suitable for MicroMatrix®
Extracellular Matrix Products
MicroMatrix® Dermal Repair Powder
What Types of Wounds are Suitable?
MicroMatrix® Dermal Repair Powder is indicated for a variety of partial and full-thickness wounds. It is particularly relevant in irregular wound beds, where it helps address challenging contours and geometries (tunneling, undermined areas, ...).
■ Chronic Wound Management: MicroMatrix® Dermal Repair Powder has been shown to be effective in the treatment of chronic wounds, such as diabetic foot ulcers and venous leg ulcers. These wounds often fail to heal due to underlying conditions like poor blood circulation and chronic inflammation. MicroMatrix® allows for rapid progression of the wound healing process by providing a scaffold for cellular infiltration and tissue deposition3
■ Acute Wound Healing: MicroMatrix® Dermal Repair Powder can be used in the management of acute wounds such as surgical wounds, traumatic injuries (abrasions, lacerations, second-degree burns, and skin tears), donor sites/ grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence. Its ability to promote rapid tissue regeneration makes it ideal for situations where quick wound closure is desired.
■ Reconstructive Surgery: in reconstructive surgery, MicroMatrix® Dermal Repair Powder is used to support the healing of soft tissue defects and to facilitate the integration of grafts. It can be used in conjunction with other collagen-based devices, such as Integra’s Dermal Regeneration Templates, to support wound closure in complex reconstructive procedures.
■ Irregular wound beds: MicroMatrix® Dermal Repair Powder helps to address contour challenges (e.g. uneven, tunneled, undermined wounds).
Warnings, Precautions, Storage and Complications:
■ If active infection is present, treat patient to resolve infection prior to device application.
■ Do not use glass vial if cracked, broken, or otherwise damaged.
■ Once package is open, do not reseal. Delayed use of remnant or resealed material could increase the likelihood of exposure to excess moisture or product contamination, increasing the risk of adverse event or infection.
■ Always use aseptic technique when handling device.
■ Do not tap the glass vial with metal object or handle in a way that may cause the glass to break and contaminate the wound.
■ Exposure to contaminated or infected field can lead to rapid breakdown of device.
■ Complications and reactions are possible with any soft tissue repair, including but not limited to: infection, increased chronic inflammation, allergic reaction, unexplained fever or chills, excessive redness, pain, or swelling.
■ MicroMatrix® Dermal Repair Powder is not indicated for treatment of alopecia.
■ Do not use on patients with known sensitivity or allergy to porcine materials.
■ Do not use on third-degree burns.
■ This device is intended for one-time use.
MicroMatrix® Dermal Repair Powder Masterclass GUIDES
What Is the Evidence?
The clinical efficacy of MicroMatrix® Dermal Repair Powder is supported by several studies and case reports, demonstrating its effectiveness in various wound healing and tissue regeneration scenario. Inflammatory Response
■ MicroMatrix® Dermal Repair Powder provides an environment where the body is more likely to exhibit a higher ratio of M2 (pro-remodeling) to M1 (proinflammatory) macrophages1,2
■ In a prospective case control study, wound management with UBM resulted in a statistically significant decrease in M1 to M2 scores for both diabetic (DM) and non-diabetic (non-DM) patients, which correlated with the rate of wound area reduction1,2
■ UBM was associated with wound size reduction in both groups: DM SUBJECTS 35% (±14%) and NON-DM SUBJECTS 43% (±18%)1,2
■ MicroMatrix® Dermal Repair Powder offers a wound management solution for irregular, tunneled, or undermined wounds. Applied as either a powder or paste, the particulate solution provides intimate contact with all areas of the wound bed.
■ MicroMatrix® Dermal Repair Powder offers quick tissue formation to support wound closure by permitting cell infiltration and neovascularization1,4,5,6.
■ MicroMatrix® Dermal Repair Powder provides a cost-effective alternative for the management of complex wounds14
■ MicroMatrix® Dermal Repair Powder allowed for healing of complex wounds at lower costs due to requiring less material and employee hours than NPWT with comparable healing times14.
Figure 3: An irregular wound
Figure 4: Depiction of a Pro-inflammatory Macrophage
MicroMatrix® Dermal Repair Powder
Extracellular Matrix Products
MicroMatrix® Dermal Repair Powder
Key Points
■ MicroMatrix® Dermal Repair Powder is a versatile and clinically proven product that can make a difference in wound healing and new tissue deposition. Its collagen-based scaffold supports cellular infiltration, angiogenesis1,5,5,6 and site-appropriate tissue formation1,7-12, making it an effective solution for a wide range of clinical applications.
■ MicroMatrix® Dermal Repair Powder provides an environment where the body is more likely to exhibit a higher ratio of M2 (pro-remodeling) to M1 (proinflammatory) macrophages1,4. A lower M1 to M2 ratio has been associated with constructive tissue remodeling, whereas a higher M1 response is associated with an encapsulation or integration response1,2
■ The clinical efficacy of MicroMatrix® Dermal Repair Powder is supported by several studies and case reports that demonstrate its effectiveness in various wound healing and tissue regeneration scenarios.
■ MicroMatrix® Dermal Repair Powder can be applied as a powder or as a paste and is particularly relevant in irregular wound beds, where it helps address challenging contours and geometries (e.g. tunneling and undermined areas), allowing intimate contact with the wound bed and contours.
References
1. Brown BN et al., Acta Biomaterialia. 2012. In animal.
2. Paige JT et al. Regen Med. 2019.
3. Agrawal V et al. Proceedings of the National Academy of Sciences of the USA. 2010. In animal.
4. Sadtler et al, Seminars in Immunology 29 (2017).
5. Song J et al. Journal of Regenerative Medicine and Tissue Engineering. 2014.
6. Remlinger NT et al. Organogenesis. 2013. In animal.
7. Gilbert TW et al, J Surg Res., 2008.
8. Nieponice A et al, Ann Thorac Surg. 2006.
9. Boruch AV et al, J Surg Res. 2010.
10. Agrawal V et al, J Tissue Eng Regen Med. 2009.
11. Young DA et al, Regen Med. 2018.
12. Young DA et al, Regenerative Medicine. 2018.
13. Reing JE et al, Tissue Eng Part A, 2009.
14. Frykberg et al., Journal of Wound Care, 2016.
Availability of these products might vary from a given country or region to another, as a result of specific local regulatory approval or clearance requirements for sale in such country or region. Non contractual document. The manufacturer reserves the right, without prior notice, to modify the products in order to improve their quality. Warning: Applicable laws restrict these products to sale by or on the order of a physician. Consult product labels and inserts for any indications, contraindications, hazards, warnings, precautions, and instructions for use. Products mentioned in this document are CE class III devices. Please contact Integra customer service should you need any additional information on devices classification. All the medical devices mentioned on this document are CE marked in accordance with the applicable European laws, unless specifically identified as “NOT CE MARKED”. Integra and the Integra logo are registered trademarks of Integra LifeSciences in the United States and/or other countries. Cytal and MicroMatrix are registered trademarks of Integra LifeSciences Corporation or its subsidiaries. For more information or to place an order, please contact Sales & Marketing EMEA, Integra LifeSciences Services (France) SAS, Immeuble Séquoia 2 97 allée Alexandre Borodine, Parc technologique de la Porte des Alpes, 69800 Saint Priest FRANCE, Phone: +33 (0)4 37 47 59 00.
Masterclass Guide: MicroMatrix® Dermal Repair Powder. Wound Masterclass, Vol 2, September 2024.