Cardiovascular News - Issue 63 - November 2021 (EU)

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November 2021 | Issue 63

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EACTS 2021 Left main revascularisation in focus

Profile Mirvat Alasnag

HBR patients irrespective of clinical presentation—for example in those with stable coronary artery disease or acute coronary syndrome—to six months or less, or potentially as short as one month. However, the recommendation is classed as level C evidence, indicating that it reflects the expert opinion and further evidence is needed. Studies investigating one-month DAPT after stent implantation have suggested that this regimen has potential to mitigate bleeding without compromising safety but have either been non-randomised or not specific to HBR patients, Valgimigli explained. MASTER DAPT sought to assess whether one month of DAPT preserved the benefit in relation to cardiovascular events, while mitigating bleeding outcomes, compared with longer treatment durations. The trial was a non-inferiority study with sequential superiority testing. Patients were candidates for the trial if they had an acute One month of dual antiplatelet or chronic coronary therapy (DAPT) following syndrome, underwent percutaneous coronary successful PCI of all intervention (PCI) using the coronary artery stenosis, Ultimaster (Terumo) sirolimusand fulfilled one or eluting stent in patients at more HBR criteria. high bleeding risk (HBR) Patients free from preserves ischaemic benefit ischaemic and reduces bleeding risk and bleeding according to the findings of events and who the MASTER DAPT study. adhered to a DAPT regimen he results of the trial were were screened The panel (l-r): presented during a Hot Line trial for inclusion 30 to Marco Valgimigli, Jean-Philippe Collet, Robert session at the European Society of 44 days after PCI. Cardiology’s 2021 congress (ESC 2021, 27–30 Byrne, Davide Capodanno Participants were and Roxana Mehran August, virtual), and published in the New randomised 1:1 to receive England Journal of Medicine. open-label abbreviated or standard DAPT. Patients in the “In patients at high bleeding risk who had undergone abbreviated treatment group immediately discontinued implantation of a biodegradable polymer Ultimaster DAPT and continued single antiplatelet therapy until study sirolimus-eluting stent, the discontinuation of DAPT at completion—except for those receiving clinically indicated a median of 34 days, compared with a continuation of oral anticoagulation, who continued single antiplatelet treatment for a median of 193 days after PCI, was nontherapy up to six months after PCI. inferior for the incidence of net adverse clinical events, Those allocated to the standard treatment group non-inferior for the incidence of major cardiac or cerebral events, and associated with a lower incidence of major or clinically-relevant non-major bleeding,” study author Marco Valgimigli (Cardiocentro Ticino Foundation, Lugano, Switzerland) told ESC 2021 attendees. The findings were described as “game-changing” by panellists at ESC 2021 in terms of their implication for the use of a shorter-duration DAPT regimen following stent implantation in HBR patients, however Valgimigli cautioned against extrapolating the trial’s results across all stent platforms, due to the prevalent use of Ultimaster during the study. DAPT—the dual-use of aspirin and a P2Y12 receptor inhibitor after PCI—is known to reduce recurrent ischaemic events, but comes at the expense of an increased risk of major bleeding in some patients. Recent clinical trials on newer generation drug-eluting stents (DESs) have shown an acceptable safety profile with a short course of DAPT, but the optimal DAPT duration in HBR patients undergoing PCI remains a topic of study. Guidelines recommend shortening DAPT duration in Continued on page 4

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MASTER DAPT “game changing” for onemonth dual antiplatelet therapy

Marco Valgimigli

Discontinuation of DAPT…was noninferior for the incidence of net adverse clinical events, non-inferior for the incidence of major cardiac or cerebral events, and associated with a lower incidence of major or clinically-relevant nonmajor bleeding.”

Konstantinos Tsioufis Renal denervation

CX AORTIC VIENNA

Multidisciplinary working vital for the next generation of aortic surgeons Building and maintaining expertise in both open and endovascular surgical techniques will play an important role in training the next generation of surgeons in order to optimise outcomes in patients with aortic disease. This is among the messages to have emerged from CX Aortic Vienna 2021 (5–7 October, broadcast), in which speakers discussed training in aortic procedures, and stressed the need for multidisciplinary teamwork between the cardiac and vascular surgery specialties. THE THREE-DAY CX AORTIC VIENNA symposium highlighted the latest developments in the comprehensive treatment of aortic disease—discussing treatment techniques and latest research from the aortic valve to the iliac arteries. Speakers from the fields of cardiac, vascular and endovascular surgery all provided perspectives on advances in aortic care, and cross-disciplinary working was a common theme throughout the programme. In particular, attendees to the event heard the importance of offering patients a choice between open and endovascular approaches for aortic conditions. During a session covering training and teamwork for optimal aortic patient outcomes, Eric Roselli, chief of adult cardiac surgery, and director of the Aorta Center at the Cleveland Clinic (Cleveland, USA), presented a view on the future of training for surgeons who will specialise in the aorta. Roselli commented that aortic disease “knows no boundaries” and offered the opinion that there is a need to “think smarter about how we offer care for this complex disease”. Both open and endovascular approaches should be complimentary, he added, and said that the focus has to be on what the patients’ needs are, based around the details of aortic disease and the interplay of comorbidities. Roselli added that aortic care requires a mixed skillset, combining both cognitive and technical attributes, and said that overlapping training programmes involving specialists from cardiology, vascular surgery, and cardiothoracic surgery are important components in the future Continued on page 9


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