This study investigates the placement of fast-growth borderland urban agglomeration ruled by informal economies in the Americas which are situated alongside the main transport infrastructure of the Pan-American Highway that serves as a ‘grand linear urban lab’. The corridor Pan-American Highway constitutes a ‘magnet’, a catalyst for empowerment of both existing urban economies that co-exist regionally in different scales and envisioning future urban developments and configurations, which are being established in edge-cities along the Pan-American Highway.