http://www.designfactory.ie/pdfs/Healthcare_Broadsheet

Design for:

Healthcare & Pharmaceuticals

Support

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Cover image from the AGI Therapeutics Annual Report 2008

Medicine,

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sit y

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Neurology, Oral 6

Mater Private Hospital

Neurosurgery,

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8 December 2005 Re. Spec. for letterhead layout

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Dear Dr. Murphy,

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Ireland

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Your Bedroom • All bedrooms are en-suite. Bathroom facilities are shared in semi-private rooms. Toilets in patients’ rooms are for patient use only. Visitors’ toilets are provided on each ward. • Hairdryers are not supplied in patient rooms but are available on request from the nurses stations. • Towels are provided in your room. • Each room is ﬁtted with a lighting control. • The nurse call handset is attached to the locker beside your bed. • Televisions and radios are located in all rooms. Headsets are available and in the interests of other patients we ask that these be used.

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Telephones For your convenience you will have a telephone located beside your bed. To make an outside call dial 9 followed by the number required. All local calls have similar charges to domestic rates and these will be included in your ﬁnal bill. Two public card-operated telephones are located in the main reception area and on Level 2 in the Hospital. Telephone cards can be purchased from the shop located across from the main reception.

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Your Privacy If you do not wish people to know that you are a patient in the hospital or if you would like to restrict your visitors or phone calls, please inform admissions staff or a staff member on your ward.

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GUIDELINES FOR ALL PRINTED LITERATURE

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A particular painting from the National Gallery of Ireland – Pieta by Pietro Perugino, c.1500 – also provided inspiration for the symbol. The stately arches evoke a sense of place and importance; the soft curved shapes evoke a feeling of calm and caring.

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The use of mobile phones is not permitted within certain areas of the Hospital, which are indicated by the notices on display.

Hepatology,

Incoming/Outgoing Mail During your stay all incoming mail will be delivered to your room. All mail received after you leave the Hospital will be forwarded to your home address. Prestamped letters may be left at the main reception or handed to the staff on your ward who will ensure they are posted on your behalf. Stamps can be purchased in the shop.

Nephrology,

Orthopaedic

slips – one for each division. Paper: 100gsm Splendorgel - Paper Assist.

Above: Letterhead, continuation sheet and compliments slip for Mater Private Hospital Dublin. Actual size: A4 and DL.

Diseases, Typeface: Verdana Regular. Type size: 8 pt.

Ophthalmology,

All stationery prints in spot colour only.

Leading (line spacing) for address, date and ‘Re.’ lines: 12 pt. Leading for body of letter: 15 pt. All text bo be range-left, raggedright. Left margin: 30mm Right margin: 30mm

Surgery, Mater Private Hospital

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Oncology,

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This led us to the ‘Icon Room’ at the National Gallery of Ireland, where various icons feature the Mother of Christ, or the Madonna. The rich colouring of icon painting provided the basis for the choice of colours for the new Mater Private brand. In the tradition of icon painting, gold leaf was often used because of its precious quality. Gold symbolises Divine energy; blue indicates the inﬁniteness of the sky and red is the colour of heat, passion, love, life and life-giving energy.

Surgery.

Cardio-Thoracic

Neurosurgery,

Orthopaedic

Management,

Gastroenterology,

The starting point for developing the new symbol, was the word itself, ‘MATER’ – meaning ‘Mother’ – and in the Christian context of the Mater Misericordiae University Hospital, meaning the Mother of Christ.

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Address, date and ‘Re.’ to appear, when possible on top third of page.

Body of letter to start, when possible on second third, approx. 104mm down from top of page.

Bottom line of address to appear 80mm down for top of page. Therefore, the bottom line will remain the same whether for a short address or a long address. If possible, keep top line of address below 56mm.

If possible, leave sufﬁcient space above address line at bottom of page. Go to continuation sheet after 260mm down from top of page.

Likewise, Date and ‘Re.’ lines to appear 92mm down from top of page.

Mater Private Healthcare

17

1. Cover of Corporate Guidelines brochure displaying identity designed for Mater Private Healthcare | 2. Spread from ‘Design Factory — On The Edge Of Europe’ | 3. Cover and spread from the Mater Patient’s Handbook and spread from the Corporate Guidelines brochure | 4. Outdoor signage designed for Mater Private Healthcare | 5. Cover of the Mater PET/CT Centre brochure displaying identity designed for the centre | 6. Illustrations used in the PET/CT brochure | 7. Spreads from the Mater PET/CT brochure

4. 5.

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cost effectiveness. The

decisions after a rigoro PET/CT provides state of the art imaging in Oncology, Cardiology and Neurology, combining functional and anatomic assessment with excellent image quality. PET/CT is safe, cost effective and has a clinical impact not replicated by any other imaging technique.

imaging modalities suc an impact in terms of

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new area in Oncology management where PET/CT can predict response to chemotherapy and/or radiotherapy prior to completion of treatment. In Cardiology, FDG PET/CT can sensitively identify hibernating myocardium

OF MOLECULAR IMAGING RESEARCH.

approved by CMS. The

In comparison to CT alone, Fluorodeoxyglucose (FDG) PET/CT can identify metastases in small lymph nodes,

on the intensity of hypermetabolic activity in tumour deposits. Evaluation of response to treatment is an entirely

PET IMAGING IS THE FIRST MAJOR CLINICAL APPLICATION

MATER PET/CT CENTRE

16 SLICE HIGH RESOLUTION PET/CT

scar tissue from residual tumour. In addition, the extent of radiotracer uptake gives prognostic information based

MATER PET/CT CENTRE

PET/CT COST EFFECTIVENESS

and predict response to revascularisation. In Neurology, the metabolic abnormalities identi identied on PET/CT commonly precede anatomic changes identi identied at MRI. Major advances in technology in the past decade have brought PET imaging from a primary research setting to mainstream routine clinical use. PET/CT now realises the full potential of PET Imaging.

1. Identity for the Royal College of Surgeons in Ireland | 2.Cover and spreads of RCSI identity guidelines | 3. Student pamphlet designed for the RCSI | 4. Letterhead and business card for the RCSI | 5. Maternity brochure designed for Mount Carmel.

Royal College of Surgeons in Ireland

1.

“When we met with Design Factory, our visual identity lacked consistency and belied our international standing. Design Factory undertook a complete communications review and implemented a cohesive identity programme with brand guidelines, detailing logo, type and colour uses. The result is a new professional and consistent look, which ties together the tradition and future facing outlook of the College, helping us better compete at a global level.”

2.

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et praesens et postera respuat aetas.

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3.

When Design Factory met the Royal College Raceday 2001 of Surgeons ﬁrst, there was no consistency to the application of their brand identity, Class of 2001 indeed the logo mark varied by publication and department. The ﬁrst step was to undertake Boston London Chigago a complete communications review, taking every piece of literature, stationery and other Otolarynology & Physiology Departments items with the College’s details applied, and in focus breaking each down into related groups by style and type. This helped create a hierarchy of items and allowed Design Factory to produce a unifying identity programme. The new and distinctive brand identity had a twofold function: to encompass the tradition of the college and also make a positive contemporary statement.

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The brand was ﬁrst rolled out into a wide range of printed materials including; stationery, A5 booklets, forms and DL’s amongst many other items. Since the initial branding exercise was completed, RCSI have been successfully producing items of promotional literature, magazines, course details and college information in a clear and consistently applied manner. Design Factory continue to work with the college producing print and digital media.

5. (1,1) -1- MtCarmelBroch_Cov_AW2.indd 12/06/2009, 12:10:58

Design of the Maternity Services brochure for Mount Carmel.

Maternity

Design Factory developed a visual concept and colour palette for Maternity Services that differentiated it from the hospital’s other functions. Combined with carefully crafted copy, the brochure offers a look and feel that mirrors the tagline – “A calm safe journey for mother and baby.”

A calm safe journey for Mother and Baby

Maternity Mount Carmel Hospital Braemor Park, Churchtown Dublin 14, Ireland T +353 1 492 2211 / 406 3400 F +353 1 492 2094 E info@mcm.ie www.mcm.ie

A calm safe journey for Mother and Baby

Practical Information for Your Stay

The Big Event

We recommend you prepare a small bag with essential items approximately 4/6 weeks before your expected delivery date. The number of items will vary according to the length of your expected hospital stay. We would ask that you leave all valuables at home.

On admission to Mount Carmel you will meet the midwife who will assess your condition and liaise with the consultant to plan your care. You will meet the obstetrician at the delivery. We support natural childbirth, and also facilitate mothers choice of pain relief.

for mother

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2/3 nightdresses (1 for labour) / pyjamas – front opening preferable

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There are various forms of pain relief for labour. You will be advised and informed during your ante-natal classes. Your midwife will also guide you as labour progresses to your individual preference and needs.

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Slippers

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2/3 Bras (good support and front opening for breast feeding)

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Comfortable clothes and shoes for going home

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Mount Carmel supplies disposable nappies, cotton wool and any toiletries for newborn baby.

123 Allah Street, Downtown, Manama, Bahrain.

Mount Carmel Hospital is fully equipped to deal with all planned and unplanned events which may arise during your stay. The philosophy of care is to provide quality maternity care in a pleasant environment where each person is treated with respect and dignity.

In the Special Care Baby Unit, a paediatrician is available on a 24 hour rota and parents are encouraged to be involved as much as possible in the care of their baby. The team liaise continuously with parents on the care of their newborn. The number of visitors to the SCBU are limited in order to protect your baby from unnecessary infection.

“A calm safe journey for mother and baby.”

• The vast majority of babies are healthy. Your baby will receive a full physical examination by the Paediatrician, normally the morning after the delivery. • Mount Carmel is the ﬁrst hospital to provide Universal Neonatal Hearing screening. • There is a standard follow up check performed on your infant at six weeks. However if you become anxious concerning your baby at any time during the ﬁrst six weeks, there are daily clinics and a telephone consultation service available.

Paediatric Care • The Hospital has a team of Consultant Paediatricians, who provide neonatal care for your baby - should this be required. They are supported by a neonatal nursing staff.

“

The atmosphere is very calm and caring in Mount Carmel. I was in good hands and had a very positive birthing experience.”

• The Maternity Unit has a fully equipped Special Care Baby Unit, suitable for babies over 32 weeks and all emergencies can be catered for in this group. The obstetrician and/or paediatrician may refer babies to the special care baby unit should they decide that a newborn requires special medical attention. Understanding that this situation is a sensitive one, our neonatal nurses give support and are always available to answer questions.

Mother of three, Dublin

Telephone +353 1 402 2183 Fax +353 1 402 2182 Email rcsibahrain@rcsi.ie

Health Insurance You may be covered fully or in part by your private health insurance. As all health insurance companies and their respective plans differ, we suggest that you call our Accounts Department (Tel: 01 406 3461) and talk to a member of staff in relation to payment. Please bear in mind that accounts will need to be settled in full before leaving the hospital.

If you are coming to the hospital for treatment of an infection, the symptoms of which include diarrhoea and/or vomiting, or a rash please inform the maternity department or nursing administration if possible before you arrive. This will help ensure that suitable accommodation is available.

Mount Carmel Hospital deals directly with the following insurers:

• Remember always to wash your hands after using the toilet and before eating and before feeding your baby and after nappy changing.

• VHI (Voluntary Health Insurance) • Quinn Healthcare (formally BUPA) • Hibernian AVIVA Health

Royal College of Surgeons in Ireland Medical University of Bahrain ??????????????? Tel +353 1 402 2411 Fax +353 1 402 2457 Email bdoran@rcsi.ie www.rcsi.ie

Philip Curtis

MBA

Admissions & Student Services Officer

• ESB Medical Provident Fund • St. Paul’s Garda Medical Aid • Non-Insured Patients

Accommodation Our private and semi-private bedrooms are fully equipped with your comfort in mind. All rooms have en-suite bathroom facilities, telephone, television and bed-side cot for your baby.

The following are a few simple steps:

• Remember to bring personal toiletries with you. Towels are supplied but you may bring your own if preferred. • If you are sharing washing facilities be careful to use only your own towel. • It is recommended that you do not walk around in socks or bare feet. Please bring slippers that have sufﬁcient grip. • If you are feeling hot, cold, and shivery do tell a midwife/doctor as you may have a temperature and early detection and treatment is in your best interest.

Infection Control Preventing infection in our patients is the principle aim of the infection control department. The department is responsible for coordinating an infection prevention and control programme that meets the speciﬁc needs of the hospital and its patients. Good hand hygiene by all is a very effective way of preventing infection. It is recommended that mothers avoid having false nails as they trap bacteria and natural nails are best kept reasonably short. For hands that appear clean, waterless alcohol hand gel is very effective for killing microbes. It is rubbed in [one squirt] to all surfaces of dry hands and evaporates rapidly. It is located in patients’ rooms for use by patients, visitors and staff.

! Advice for visitors Alcohol hand gel is located in patients’ rooms for use by patients, visitors and staff. Please help protect our mothers and babies. Do not visit if you or your child has symptoms that you suspect may be caused by an infection, e.g. diarrhoea and/or vomiting, a rash, or cough. If you need advice about this please feel free to telephone the maternity department before coming to the hospital.

Mount Carmel

General Information

1. 2.

AGI Therapeutics

A specialty pharmaceutical company focused on the development of new products based on known molecular entities.

3.

�� Annual Report & Accounts 2008

��

5.

Chairman’s and Chief Executive’s review:

Now, in early 2009, we stand on the verge of the most

OVERVIEW

the results from the ARDIS-1 Phase III efficacy study of

signiﬁcant milestone in our company’s short history, namely

2008 was a year of contrasts for AGI. From an operational

Rezular™, which we expect about mid-year. The outcome

standpoint it was a busy and successful year, dominated

of this study will deﬁne the efﬁcacy of this product and will

by our achievements in progressing the Phase III clinical

be anxiously awaited by the AGI team, potential commercial

development of our lead product candidate, Rezular™.

partners, our shareholders and indeed, patients with this limiting

In addition to managing the ARDIS clinical programme for

and underserved disease. Developing a new pharmaceutical

Rezular™, we focused considerable time and effort on our

product with blockbuster market potential such as Rezular™

regulatory and intellectual property strategy for this product. We

is a major challenge for any company, large or small, in any

also engaged in preliminary discussions with potential partners

environment. However, we believe that the skill, experience,

for this product, having identiﬁed a number of companies who

dedication and enthusiasm of the AGI team, in combination

will have sufﬁcient scale and resources to help us complete

with the continued support of our Board and shareholders, will

the development of Rezular™ and manage its launch into

enable us to meet this challenge. Looking beyond Rezular™, we believe we have amassed a clinical-stage pipeline of

the US market.

signiﬁcant potential, which we look forward to being able to further develop and realise in 2009 and thereafter.

From a corporate perspective, 2008 was certainly a challenging year. Our share price, in common with many in our sector, experienced a precipitous decline in the face of tumultuous

STRATEGY

events in the global ﬁnancial markets. We nonetheless feel

Our achievements in 2008 were very much in keeping with our

we have made signiﬁcant progress during 2008 in building

strategy to progress a broad pipeline of compounds through

the fundamental value of your company by investing in those

development for a range of GI diseases. We remain focused

later-stage assets which can potentially yield the greatest

on developing known molecular entities (KME’s) that can be

returns if successful in the clinic. We actively communicated

signiﬁcantly differentiated from current therapies, and which

on a regular basis throughout the year with our shareholders

will allow us to provide new and innovative products to serve

to inform you of progress in the business and we are conﬁdent

unmet medical needs in the gastroenterology market. We

that your patience and support of the AGI team and business

maintain our aspiration to develop in the longer term into a

plan will ultimately be rewarded.

fully integrated specialty pharmaceutical business with the

Given the uncertainties in the public markets, which restrict

own products in the market by targeting medical specialists

ability to oversee the sales, marketing and distribution of our the ability of development-stage companies such as ours

within our therapeutic areas of expertise. We expect to out-

to access further funds at a price acceptable to existing

license or partner those products that would beneﬁt from being

shareholders, we moved swiftly in 2008 to concentrate our

marketed or co-promoted by larger companies, whilst retaining

cash resources on our most advanced programmes. The

co-ownership rights to AGI’s products where possible.

considerable progress of Rezular™ is discussed more fully OUTLOOK

below, but, where resources allowed, we continued to add value to certain other products in our pipeline, completing a

2009 has started well for AGI. We announced completion of

successful proof of concept Phase II study for AGI-004 in

enrolment of ARDIS-1 for Rezular™ in IBS-D, which is the

the treatment of chemotherapy-induced diarrhoea in cancer

ﬁrst Phase III study to be undertaken by our company and

patients, while further optimising our formulation of AGI-010 in

represents a major achievement on the part of our management

collaboration with our partner, Axcan. While we have not been

and employees. We also released the preliminary results of our

able to undertake further clinical trials across the remainder of

proof-of-concept study of AGI-004 in CID in the ﬁrst quarter

the earlier-stage pipeline during 2008, we nonetheless have

which suggests that we have another promising drug in our

continued to invest intellectually in these projects, identifying

portfolio targeted, like Rezular™, at an area of high unmet

new and attractive clinical opportunities to be pursued as and

medical need.

when additional ﬁnancial resources become available.

Dr Ronan Lambe, Chairman Dublin, 1 April 2009

Dr John Devane, Chief Executive Ofﬁcer

AGI Therapeutics, plc. Annual Report & Accounts 2008 2007

05

www.agitherapeutics.com Products Product Candidate

Target Indication

Rezular™ (AGI-003)

IBS-D

Rezular™ XL

IBS-D

Clinical Stage Preclin

(AGI-004)

CID

(AGI-010)

GERD/NAB

(AGI-022)

Ulcerative Colitis

(AGI-006)

Functional Dyspepsia

Proof of Concept

Phase II

Phase IlI

Gastroparesis Refractory GERD CINV

Rezular™ (ARVERAPAMIL, AGI-003) IN IBS-D

one available product, Lotronex® (Prometheus/GSK), which is

Irritable bowel syndrome comprises a cluster of gastrointestinal

approved as a limited-access treatment for women only with

symptoms which are likely to be life-long and which affect

severe IBS-D. Hence there is a signiﬁcant unmet medical need

between 10% and 20% of the population in developed markets.

for new, safe and effective IBS-D treatments and we estimate

IBS remains one of the most common diagnoses made by

the market opportunity for new IBS-D therapies to be greater

gastroenterologists and can lead to a substantial reduction in

than $2.5 Billion in the US alone.

patients’ quality of life, accompanied by considerable socioeconomic and psychological consequences. Altered intestinal

The Phase III development of Rezular™ was our primary focus

motility is a major component of IBS and patients are diagnosed

in 2008.

and sub-typed according to their predominant symptom of bowel disturbance. IBS-D is estimated to occur in one-third

We have named the Phase III clinical programme for Rezular™

of all IBS patients, and represents a signiﬁcant unmet medical

“ARDIS”. In late 2007, we commenced screening and enrolment

need, as there are currently few safe and effective therapeutic

of patients into ARDIS-1, a randomised, double-blind, placebo-

options available to these patients.

controlled, parallel group efﬁcacy /safety study in IBS-D patients

Rezular™ is an orally administered multiple mechanism

and three dose levels of Rezular™) and patients are treated

(both men and women). There are four treatment arms (placebo intestinal regulator, a ﬁrst-in-class mechanism for the treatment

for 12 weeks of double-blind therapy. The primary endpoint is

of IBS-D. Rezular™ contains arverapamil, a single enantiomer

patient global relief of IBS symptoms, as agreed with the US

moiety of the racemic drug verapamil. Unlike the currently

Food and Drug Administration (FDA). At the end of double-

available commercial forms of racemic verapamil (a mixture

blind therapy in ARDIS-1, patients become eligible to enrol into

of two enantiomers), Rezular™ shows a dominant activity

ARDIS-3, a Phase III safety study, which is designed to capture

in treating the symptoms of IBS-D without the traditional

safety data in a target of 100 patients treated with Rezular™

cardiovascular actions of the racemic drug. The efﬁcacy and

for 1 year of continuous therapy at the highest dose. By the

safety of Rezular™ in IBS patients has already been established

end of 2008, 123 clinical centres were enrolling patients in

in a Phase II trial, the preliminary results of which were reported

the United States, Europe and South America for ARDIS-1

by the Company in 2006.

and ARDIS-3. ARDIS-1 is the ﬁrst of two ongoing Phase III studies which will be included in a future New Drug Application

Rezular™ is the most advanced product in development for

(NDA) submission to the FDA for approval of Rezular™ in the

the treatment of IBS-D in the US, where there is currently only

U.S. In January 2009, we announced that we had completed

AGI Therapeutics, plc. Annual Report & Accounts 2008

07

4.

1. Image used in 2008 AGI Therapeutics Annual Report | 2. Photographic details of the 2006 Annual Report | 3. Front Cover and spreads from 2008 Annual Report | 4. Slides from AGI Therapeutics powerpoint presentation | 5. Homepage of AGI Therapeutics website

1.

Design Factory identiﬁed and tied together the key elements that make up the Irish Pharmaceutical Healthcare Association’s brand and designed a brand identity that both shows solid values and contemporary style and accurately reﬂects the IPHA’s core remit - to represent the international research-based pharmaceutical industry in Ireland.

2.

The Irish Pharmaceutical Healthcare Association (IPHA) represents the international research-based pharmaceutical industry in Ireland. Our brief was to communicate well-being and innovation as the primary brand message of this organisation. Derived from the ancient ﬂower of life pattern and the pattern of basic molecular structure, this symbol projects perfect form, proportion and harmony. It is a symbol of the connections, both scientiﬁc and technological, which weave throughout our daily lives.

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Dear Sir/Madam,

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_________________ John Smyth

��

IPHA IRISH PHARMACEUTICAL HEALTHCARE ASSOCIATION www.ipha.ie

Franklin House 140 Pembroke Road Dublin 4 Ireland

T (+ 353 1) 6603350 F (+ 353 1) 6686672 E info@ipha.ie (general enquiries) E accounts@ipha.ie (queries about accounts & subscriptions)

...well-being and innovation ...

4.

www.azurpharma.com

1. Identity designed for the Irish Pharmaceutical Healthcare Association | 2. Stationery designed for the IPHA | 3. Pull-up stands designed for the IPHA | 4. Website designed for Azur Pharma

Design Factory worked closely with Dublin headquartered private pharmaceutical company Azur Pharma, designing and developing the look and navigation structure of their website. As the main information portal for the group, it was essential that Design Factory’s clean design principals were reﬂected in the production of this key marketing device.

Azur Pharma

Irish Pharmaceutical Healthcare Association

3.

1.

3.

4.

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5.

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6.

CPA, Positive Options, Think Contraception

2.

1. Images used for AGI Therapeutics Annual Reports

1.

Client List Mater Private Healthcare... Mater PET/CT Centre... Royal College of Surgeons in Ireland... Mount Carmel Medical Group... AGI Therapeutics... Irish Pharmaceutical Healthcare Association... Azur Pharma... Crisis Pregnancy Agency... Thérapie... The Bodyclinic

www.designfactory.ie

Call Design Factory and ask for Conor Clarke or William Hart. Alternatively, email conor.clarke@designfactory.ie or william.hart@designfactory.ie

+ 353 1 809 0010 Conor Clarke is a Director of Design Factory. He worked at the BRS Design Partnership (now Eden Design & Communications) in Amsterdam before joining Design Factory as a partner in 1985. He has served as a committee member of the SDI (Society of Designers in Ireland) and ICAD (Institute of Creative Advertising and Design). He has been a regular award winner at ICAD with his work featured in international publications such as ‘Who’s who in Graphic Design’ and the ‘New York Directors Club Annual’. Conor specialises in corporate branding.

William Hart is an honours graduate from the University of Kent (UK) where he studied Politics and International Relations. Before joining Design Factory in 2003, he worked in a number of marketing roles, both in the UK and Ireland, planning and overseeing the implementation of marketing strategy and developing new business opportunities. William has worked on all Design Factory’s branding projects for the past 6 years, helping identify strategy and planning for the design stages. These projects have included; The Road Safety Authority, Mater Private Healthcare and Blackpool in Cork amongst others.

100 Capel Street, Dublin 1, Ireland | Tel. +353 1 809 0010 | info@designfactory.ie | www.designfactory.ie

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