The time to build it is now!’
What this patent means This specific health technology is • recognized by a government agency, • novel and has not existed before, • unique and not available anywhere else, • protected and cannot be imitated.
What is the difference from a pharmaceutical drug patent
Target markets
Purpose of patents This information sheet provides health research established in con nection with natural disease pre vention. For patients, we rec ommend to see a therapist or trained consultant to determine your individual health needs.
www.drrathresearch.org
Consequences for your health Consequences for national economies
#1896/01EN/231122 Art. Nr.: 30047
The Dr. Rath organization oper ates under a nonprofit roof and all profits are used to promote further independent research and education in natural health.
E US PAT TH
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Over the ensuing decades, the Institute’s research team, under the leadership of Dr. Aleksandra Niedzwiecki, has extended this life saving research to comprise natu ral prevention of cancer, diabetes, viral and bacterial infections and Senior scientists of the Dr. Rath many other diseases. Research Institute with The approval of this preventive Dr. Niedzwiecki (center) health research by patent offices Dr. Rath Research Institute around the world provides the sci in San Jose, California entific basis for effective preven tive health strategies globally. Pa tients, therapists, governments and, above all, millions of people now have effective, safe, natural health approaches avilable to help to prevent widespread diseases.
Patented benefit of miconutrient combinations
ENT OF AT
Dr. Matthias Rath
Micronutrients and Eye Health
T OFFIC EN
The Dr. Rath Research Institute is a world leader in sciencebased natural health. Three decades ago, Dr. Matthias Rath – together with twotime Nobel Laureate Dr. Linus Pauling (†1994) – was already pub lishing groundbreaking discoveries on the importance of vitamins in fighting cardiovascular diseases.
‘Science‐based natural health is the basis of modern, preventive health care.
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Nobel Prize‐winner‐supported research paves the way to preventive health care
Pharmaceutical investment business
Natural health community
Disease management
Disease prevention
Legal tools to secure return on investment (ROI) Cementing continua tion of diseases as global markets
Disease prevention and potential elimination
Exploding health care costs
Less diseases = lower health care costs
Scientific acknowledgement
Natural health research – the basis of preventive health
Eye health
Eye problems can appear at all stages of life, with children and older people being particularly af fected. Worldwide more than two billion people have vision prob lems, with more than half of these being preventable. Eye diseases, such as cataracts, glaucoma, dia betic retinopathy, agerelated macular degeneration and others are associated with the ultimate risk of blindness. Conventional medicine is con fined to treating the symptoms of eye disease with pharmaceutical drugs, many of them causing side effects. Betablockers, used for glaucoma treatment, may slow the heart rate, and cause asthma at
US Patent No. US10716767B2
Composition for eye health Inventors: Aleksandra Niedzwiecki, Matthias Rath, Anna Goc, Waldemar Sumera Publishing date: July 21, 2020
tacks and disorientation. Side ef fects of other pharmaceutical eye drugs include allergic reactions and inflammation. Re�na
Retinal epithelial cells
Cornea
Light Pupil
Lens Op�c nerve
Iris Ciliary body
Cross section through the eye. Corneal cells and retinal cells (red boxes) are par ticularly vulnerable to oxidative stress and other biological damage. Such damage can lead to edema, molecular waste deposition, and overshooting formation of new blood vessels (blue, yellow, purple symbols at right).
Micronutrient combination pat ented to help prevent oxidation related eye damage Our institute evaluated the efficacy of vitamin C alone and in combina tion with certain other micro nutrients for their efficacy to pro tect eye cells against oxidative damage. The comprehensive research re sults form the basisi of this patent. They show: • Figure 1 (from the patent): Micronutrient combination helps to prevent oxidative damage to eye cells. The first column (‘negative control’) shows the sur vival of cells that are unchallenged by oxidative stress. The second col umn (‘positive control’) shows the significantly reduced survival rate of eye cells when they are exposed to the damaging oxidative agent hydrogen peroxide (H2O2). Expo sure of corneal and retinal epithe lial cells to oxidative stress de creased the viability of these cells by over 60% (‘positive control’).
This means that under the expo sure to such oxidative stress, fewer than 40% of eye cells were able to survive. However, the survival of both corneal and retinal cells ex posed to oxidative stress was sig nificantly increased in the pres ence of vitamin C (column 3). When these challenged eye cells were protected by a combination of vitamin C and other selected micronutrients (column 4), the protective effect was even higher, and almost all eye cells survived.
• Figure 2 (from patent): The tested micronutrient combination helps to prevent diabetesrelated damage to eye cells. Another highly damaging process affecting our eyes involves metabolic changes occurring in diabetes. One of the most frequent complica tions of this condition is diabetic eye disease (retinopathy), and even blindness. Diabetes event ually leads to the formation of ad vanced glycation end products (AGEs), a sort of ‘sugar crust’ covering proteins, lipids, DNA and other constituents of our body. Figure 2 presents the effects of vit amin C alone and in combination with selected other micronutrients on protecting retinal and corneal eye cells against damage by AGE proteins, caused by high sugar levels. Under protection by vitamin C, the survival of both types of cells in creased – however, only the com bination of micronutrients was able to achieve maximum efficacy with about 90% eye cells surviving in the presence of AGEs.
2
2- Viability (OD 490 nm)
Our modern understanding of the cellular root of eye diseases rec ognizes the primary cause of vision problems as a longterm deficiency of essential micronutrients in the eye cells. Compared with other or gans, the eye is particularly sus ceptible to oxidative damage, owing to its exposure to light and high metabolism. Therefore, die tary antioxidants and natural com pounds that help to prevent oxi dative damage and inflammation are important in protecting the biological structure and function of our eyes. Particularly important are vitamins C, A, E, carotenoids lutein, zeaxanthin and βcarotene, the trace element zinc, as well as polyphenols.
1.75 1.5 1.25 1 0.75 0.5 0.25 0
Nega�ve contol
Posi�ve control (hydrogen peroxide)
Vitamin C
Micronutrient combina�on
Re�nal cells (RPE) Corneal cells Figure 1: Micronutrient combination helps to prevent oxidative damage to eye cells
2 1.75
(OD 490 nm)
The world’s first patented health technology to support normal eye function – naturally
Micronutrient combinations to protect normal eye function
1.5 1.25
2- Viability
Making prevention the focus of modern health care
1 0.75 0.5 0.25 0
Nega�ve control
Posi�ve control (glycoaldehyde-AGE)
Vitamin C
Figure 2: Micronutrient combination helps to prevent diabetesrelated damage to eye cells
Vitamins C, A, E Grape seed extract Larginine Blueberry extract Lcysteine Alpha lipoic acid Lycopene Lutein and other micronutrients
Find further information and studies on eye health on this website.
Corneal cells
Micronutrient combina�on Re�nal cells (RPE)
Claims allowed by Patent Office (excerpt): A nutrient mixture that … ‘pretreats a retinal pigment epithelium and corneal cell of mammals [including hu mans] before an oxidation damage occurs.’