Cellular Health and COVID-19 by Dr. Rath

Dr. Rath Health Foundation

CELLULAR HEALTH and

COVID-19

Questions and Answers Dr. Aleksandra Niedzwiecki PhD, Dr. Matthias Rath, MD

Cellular Health and COVID19 – Questions and Answers 1st Edition © 2022 Dr. Rath Health Foundation Dr. Aleksandra Niedzwiecki PhD, Dr. Matthias Rath, MD Distribution: Dr. Rath Education Services B.V. Postbus 656, NL-6400 AR Heerlen Tel.: 0031-457-111 222 Fax: 0031-457-111 119 Email: info@rath-eduserv.com Internet: www.drrathbooks.com Published by the Dr. Rath Health Foundation. All rights reserved. Individual pages of this brochure can be copied for private and noncommercial purposes only. Any direct or indirect commercial use of this brochure or of its parts in any way is strictly forbidden without the written permission of the authors. 2.

Content Foreword ________________________________________________________

Introduction ______________________________________________________

The Virus That Causes COVID-19________________________________________

Questions and Answers ______________________________________________ 10 Nutrition and COVID-19 ______________________________________________ 18 Relevant Publications ________________________________________________ 26

Foreword Dear Reader, This booklet summarizes breakthrough research contributions towards ultimately ending the COVID-19 pandemic. This research was conducted by a team of scientists at the Dr. Rath Research Institute, one of the few independent and non-profit research institutions in the world. The starting point of this compelling research project were two scientific facts: 1. The COVID-19 pandemic is a human-specific pandemic. While animals can get infected with the coronavirus, they do not fall sick or die in pandemic proportions. The single most important genetic and metabolic difference between humans and essentially the rest of the animal world is the inability of humans to produce vitamin C (ascorbic acid) in their own body by conversion from sugar (glucose). Thus, the optimum intake of vitamin C and other micronutrients became the focus of our research. 2. Any approach to control the COVID-19 pandemic by targeting a single type of the coronavirus must inevitably fail, a fact that, unfortunately, has been witnessed by the world community over the past years. Viruses constantly mutate, rendering any vaccine developed against one variant of the coronavirus less effective – or even ineffective – against other mutations of this virus. Thus, our research team took a fundamentally different approach by focusing on the other end of the infection process, i.e., the human body cells. Our goal was to develop effective and safe approaches to increase the resistance of cells from being invaded and infected by coronaviruses – irrespective of subtype or mutation. This brochure summarizes the breathtaking results of this research project. It documents that plant-derived bioactive molecules, also known as micronutrients, are able to protect all known infection pathways of the coronavirus to human cells.

Moreover, these micronutrients have been scientifically proven effective against all subtypes of the coronavirus, including its Alpha, Beta, Gamma, Delta, Epsilon, Mu, and Omicron variants. This brochure provides the scientific evidence that effective and safe tools are available to help end the current Covid-19 pandemic and to help prevent future pandemics with yet unknown mutations of the coronavirus. This knowledge can now be used by people around the world as well as by responsible governments seeking effective, safe, and affordable long-term public health strategies to ultimately end this pandemic. We encourage every reader of this book to help spread this unique information and forward it to political decision-makers, who are ultimately responsible for protecting the health of the people in an effective and safe way. From now on, there is no reason anymore why the human species should be the only species on our planet to be mortally affected by coronaviruses. Wishing you good health,

Dr. Aleksandra Niedzwiecki

Dr. Matthias Rath

Introduction THE COVID-19 pandemic, which originated in China in November 2019, had by December 2019 begun its rapid spread all over the world. By January 2022, the pandemic had claimed more than 5.5 million lives, and more than 350 million people had been diagnosed with COVID-19. In addition to the human cost, this pandemic continues to deplete the economic resources of nations, to decrease productivity, and to further deepen social and economic divisions between nations, as well as within nations and communities. For more than two years, the global community has been exposed to inconsistent administrative decisions at different levels, silencing the opposing scientific and medical views on public health measures, pro-

moting massive numbers of vaccinations while discounting therapeutic approaches, and, overall, ignoring the nutritional aspects of immunity. Today we have come to the crossroads: either we continue on this path, or we put pressure on the policy makers to stop politicizing science and protecting pharmaceutical business interests at the expense of human health. We need a fresh, independent approach to control COVID-19 effectively and safely. This brochure is intended to answer key questions about COVID-19, current vaccines and how the implementation of a science-based natural approaches can help in bringing the COVID-19 pandemic under control.

The Virus That Causes COVID-19 The novel virus that caused this pandemic was denominated severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2. It belongs to a large family of coronaviruses that cause a range of illnesses, including the common cold and previous MERS and SARS epidemics. SARS-CoV-2 is a new strain that has not been previously identified in humans. It primarily attacks the respiratory system, but also the digestive tract, the urinogenital and central nervous

system, cells lining the blood vessels, and other organs. Hence, people infected with this virus report a variety of symptoms. SARS-CoV-2, like other viruses, is a tiny infectious agent that can only thrive and multiply after getting inside the cells of a host. This virus is made of a single strand of a genetic material, RNA, surrounded by proteins and other components that help the virus to bind to the cell membrane, to © Dr. Rath Health Foundation 7.

penetrate host cells and to hijack the biological systems of the host, to multiply and spread through the body. The SARS-CoV-2 virus has the characteristic appearance of an enveloped sphere with projecting glycoprotein spikes (resembling a corona), which surround a core consisting of proteins and the RNA that contains the viral genetic information. Spike proteins, which protrude from the virus capsule, are critical for facilitating viral entry into the host cells, first by attaching to the specific structures on the cell surface (called ACE2 receptors), and then by fusing viral and cellular membranes.

ACE2 receptors play an important role in viral infectivity as the “entry doors” for the virus. Therefore, measures that can inhibit the binding of a virus and limit the number of ACE2 receptors are important in preventing viral infection of the cell.

SARS-COV-2

Spike ACE2 receptor

Cell surface

Cellular Health Science Represents a Universal Approach to SARS-CoV-2 and Its Mutated Variants From the very outset, our research at the Dr. Rath Research Institute (DRRI) did not focus on developing vaccines against the original coronavirus or one of its mutations. Our research team took a fundamentally different approach based on the following scientific analysis: 1. All coronaviruses use the same molecular “doorway” (the ACE2 receptor) to enter the cells of the lung and other organs, to infect the human body. 2. Any therapy that significantly down-regulates the production/expression of these ACE2 receptors in our body must lead to a significant protection against COVID-19 infections. 3. Since all mutations of the coronavirus use this very same “doorway”, such an approach would also signify a major step towards effective prevention of all future mutations of the coronavirus – a precondition to end the COVID-19 pandemic. 4. Completely blocking these “doors”, e.g., with a vaccine/antibody strategy directed against the ACE2 receptors, could lead to severe health problems, since a minimum level of these receptors is essential for health. Understanding how these “doorway” molecules can be down-regulated to a safe level is a key step towards developing effective public-health strategies that can protect against infections with current coronaviruses, as well as with future, as yet unknown, mutations. Our research represents a novel approach to COVID-19 by correctly identifying critical metabolic targets involved in this viral infection and controlling them through a coordinated action of select natural compounds. This can lead to achieving universal and safe control of COVID-19 (see graphic). Micronutrients’ effects also extend to strengthening the immune system and can be applied in COVID-19 therapy by curbing the inflammation process associated with this infection – a potentially fatal immune reaction known as a “cytokine storm”.

A. Micronutrients can prevent virus from infecting cells

✂

Furin

✂

Virus

TMPRSS2

ACE2

✂

B. Micronutrients suppress viral metabolism and its multiplication in infected cells

• Inhibit binding of viral spike protein to ACE2 receptors on cells • Decrease availability of ACE2 receptors • Inhibit cellular entry of viruses by interfering with activity of enzymes facilitating this progress Viral RNA

Nucleus

Cathepsin L

Prevent multiplication of viral particles in infected cells

Questions and Answers • What is the definition of a vaccine? The original definition of a vaccine is “a product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease.” Based on this, it is apparent that currently used vaccines do not fulfill this criterion, since they do not protect against coronavirus infection and spread.

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Evading criticism of mass vaccinations with already-produced vaccines, the US CDC (Center for Disease Control) agency changed the definition of a vaccine in September 2021. Now, a vaccine is defined as: “a preparation that is used to stimulate the body’s immune response against diseases.” This has been perceived by many as dishonest and deceiving.

• How do COVID-19 vaccines based on RNA (manufactured by Pfizer and Moderna) and DNA (from Johnson & Johnson and Oxford/AstraZeneca) work? The most widely used COVID-19 vaccines substantially differ from all vaccines that have been applied for decades. Traditional vaccines use a weakened or dead pathogen or its protein to simulate an infection. As a result, they trigger the production of antibodies and memory cells that will recognize the actual microbe and respond if the body is infected with it. New types of COVID-19 vaccines use the genetic code of the virus, either RNA or DNA, to produce viral proteins in host cells and to generate an immune response. Specifically, these vaccines deliver a tiny piece

of genetic code from the SARS CoV-2 virus to your muscle cells, giving those cells instructions, or blueprints, for making copies of viral spike proteins. Your body produces these proteins for a few days, training the immune system to recognize and attack the spike protein the next time it encounters it. These vaccines were heralded as highly effective (over 95%) in preventing SARS-CoV-2 infection and viral spread. The most recent data show decreased efficacy to 84% or 75% after six months, and even less in the case of the new coronavirus Omicron variant.

Questions and Answers • Why do vaccinated people get COVID-19? With the introduction of COVID-19 vaccines, the health agencies in the US and EU stated that vaccinated people are almost fully (over 90%) protected against infection. This would eliminate the need for wearing masks or social distancing.

Soon however, it became clear that vaccinated people are prone to so called “breakthrough” infections and can spread the virus. In consequence, the rules of wearing masks, sheltering and social distancing now apply to entire populations (vaccinated and unvaccinated).

There are a variety of reasons why vaccinated people can get COVID-19.  Viral mutations: Over the past two years of the COVID-19 pandemic, the original virus (SARS-CoV-2) changed its appearance (mutated), with the result that the vaccines developed against the original virus are not as effective as initially claimed. This is especially seen with the Omicron variant, which has more than 45 changes in its spike protein and is largely resistant to the vaccines. Some evaluations indicate only about 20% antiviral efficacy of the Pfizer vaccine, which is significantly lower than the 97% efficacy initially claimed in the case of the original SARS-CoV-2. Pfizer has already indicated that it is working on an Omicron-specific vaccine. Does this mark the beginning of a series of vaccinations for every potential viral mutation?  Weak immunity: Most of the vaccinated people who develop COVID-19 have other health risk factors, such as various diseases (cancer, high blood pressure, diabetes and others), are of advanced age or overweight, all of which impair their immune response. It is important to note that various nutrient deficiencies triggered by unhealthy diet, smoking, taking various medications, or psychological stress also have a negative impact on our immunity.  Potential toxic effects of the viral spike protein: Another reason for infections occurring in vaccinated individuals could be construed from the results of a scientific study conducted in Sweden (reference). The study showed that the coronavirus spike protein, which is produced in human cells in both infected and vaccinated people, can

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reach the cell nucleus and impair a vital DNA repair process. Failure to effectively repair cellular DNA can undermine our immunity (antibody response) as well as facilitating the development of cancer and other diseases. This would corroborate the disputed data from Denmark showing that 8% of Omicron infections occur among the triple-vaccinated, while just 1.2% occur among unvaccinated people.  Diminished vaccine efficacy: With time we have learnt that antiviral protection by both RNA- and DNA-based vaccines diminishes after a few months. Now, health authorities recommend that renewed vaccine injections (boosters) should be done five months or even earlier from the last vaccination. However, it appears that even boosters do not assure full protection against mutated forms of coronavirus, but apparently can only mitigate the clinical severity of the disease. In our interpretation, this clinical benefit may result from just aggravating the immune system (i.e., by use of adjuvants, ingredients added to enhance immune response), rather than from the vaccine itself, which has limited efficacy against new variants of coronavirus. Some pharma companies (e.g., Pfizer) have already indicated that they are working on new vaccines that will target specific viral mutations, similarly to the yearly flu vaccines. This looks like the beginning of a never ending cycle…

In general, mass vaccination – on a global scale – with RNA/DNA products, conducted over the past two years, shows that these vaccines, which were generated against

SARS-CoV-2, do not fully protect against viral infection and spread, but can only decrease the severity of disease symptoms.

Side effects of the COVID-19 vaccines Dr. Rath Education https://www.dr-rath-education.org/side-effects-of-the-covid-19-vaccines/

Questions and Answers • What are the coronavirus “mutants”? Since the onset of the COVID-19 pandemic, many distinct variants (mutations) of the original virus, SARS-CoV-2, have been identified, which have displayed changes in the amino acid sequence of the spike protein. Many of these changes can affect the infectivity and transmission of the virus, as well

first detected in the UK, Beta in South Africa, Gamma in Brazil, Delta in India, Mu in Colombia, Lambda in Peru, and Omicron in South Africa. Among these, the mutation common to the Alpha, Beta, Gamma and Omicron variants has contributed to the enhanced infection and transmission

Antibodies against the original virus may not recognize its mutated form

Antibodies

Genetic changes (mutations) over time Virus A

Virus A1

as evading the host’s immune response. Furthermore, the vaccine-generated antibodies that target the protein sequence in the spike of the original SARS-CoV virus can become less effective, or completely ineffective, against viral mutants.

of the virus and reduced vaccine efficacy. As of the beginning of 2022, the Omicron variant, with a high transmission rate but lower severity of symptoms, dominates in many countries over the Delta variant, which causes more severe disease.

Several mutations of the virus, first identified in various countries, have now spread throughout continents. The Alpha form was

Some scientists suggest that the high infectivity of the Omicron variant results from the spike protein’s higher binding affinity

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to ACE2 receptors. This information highlights the necessity of expanding metabolic targets in curbing this viral infection by including means to decrease the availability of ACE2 receptors on the cells. This could be achieved with the nutrient composition developed at the DRRI. Waning efficacy of

the vaccines also confirms that aiming at one target (the viral spike protein) is not the most effective way to control this virus. The cellular health approach is based on simultaneous control of key cellular mechanisms involved in the complex metabolic pathways of infection.

• What does a “booster” do? A booster is an extra vaccine dose administered after the original (or primary) dose, to remind the body’s immune system about the virus against which it needs to defend. These boosters can be administered weeks, months or years later. Some traditional vaccines, such as those against childhood diseases measles, whooping cough and meningitis, are effective into adult life, as the immune system retains a memory of the infectious agents. Other vaccines, such

as tetanus, require booster shots every ten years or so, as the original immunity wanes. In the case of COVID-19 vaccines, the booster shots made by Pfizer and Moderna are recommended after five months from receiving their full dose, while Johnson & Johnson’s vaccine calls for a booster after just two months. Boosters for individuals who are moderately to severely immunocompromised are recommended after four weeks from the original vaccination.

Europe’s drug regulator warns excessive COVID boosters could lead to ‘problems with immune response,’ joining WHO in pushback BY DAVID MEYER; January 12, 2022 https://fortune.com/2022/01/12/ema-who-covid-fourth-boosters-pfizer-flu-endemic/

Questions and Answers • What side effects are associated with vaccines? It is important that the risks and benefits of COVID-19 vaccines should be monitored for a long time and clearly communicated to the public without political or economic bias. Official data report that most people experience typical reactions shortly after the vaccination. In the case of RNA vaccines (Pfizer and Moderna), more symptoms appear after the second dose. These reactions include pain, redness or swelling at the injection site, tiredness, headache, fever and nausea, which are considered to be signs of the immune response. Experience with conventional vaccines tells us that side effects generally happen within six weeks of receiving a vaccine dose. Therefore, the U.S. Food and Drug Administration (FDA) collected data on each of the authorized COVID-19 vaccines for a minimum of eight weeks after the final dose. These new types of vaccines require that their safety is monitored while the vaccines are in use. This monitoring has been confirmed by the CDC. So far, the health authorities in the US, the UK and other countries have released re-

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ports of rare cases of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the outer lining of the heart) in adolescents and young adults. These occurred more often after getting the second dose than after the first dose of either the Pfizer or the Moderna COVID-19 vaccine. These reports led to the temporary suspension of the Moderna vaccine in the UK, Sweden, Denmark and Iceland while the US required the addition of a warning label on both the Moderna and the Pfizer COVID-19 vaccine. In the UK the Moderna vaccine is not recommended for children under 12. In April 2021, the application of the Johnson & Johnson (DNA-based) vaccine was temporarily paused, pending the investigation of serious blood clot conditions (thrombosis with thrombocytopenia syndrome, or TTS). TTS causes blood clots with low level of platelets – a serious condition requiring immediate intervention. Nearly all reports of TTS have been in adult women younger than age 50. The investigation concluded that the potential benefits of the J&J vaccine outweigh its known and potential risks, and administration of this vaccine was allowed to continue.

In January 2022, a safety panel of the European drug regulator recommended adding a rare spinal inflammation known as “transverse myelitis” as a side effect of AstraZeneca’s (DNA-based) vaccine. Transverse myelitis is characterized by an inflammation of one or both sides of the spinal cord, and can cause weakness in the arms or legs, sensory symptoms or problems with bladder or bowel function. Earlier, this vaccine was investigated for rare cases of TTS, which led to several countries restricting or halting its use. The European Medicines Agency’s safety committee also reiterated its recommendation of a similar warning to be included for Johnson & Johnson’s one-shot vaccine. https://www.scmp.com/news/world/europe /article/3163478/coronavirus-rare-spinalcondition-side-effect-astrazenecas-covid

In addition to the official statements, numerous reports of possible vaccine-related adverse effects have been communicated by physicians, published as case reports (including the recent one on severe jaundice) and through other media. These are often ridiculed, ignored or blocked by the social media channels. A thorough evaluation of such cases is important. Censorship and the dismissal of all reports as “quackery” does not enhance public acceptance of the vaccines, but rather breeds distrust in health authorities and reinforces the perception of their focus on personal or political gains above the health interests of the people. An open and professional discussion on this topic is needed, to address different points of view, many of which come from scientific and medical professionals from well-respected academic and medical institutions.

Side effects of the COVID-19 vaccines Dr. Rath Education https://www.dr-rath-education.org/side-effects-of-the-covid-19-vaccines/

Nutrition and COVID-19 HEALTHY HOST

Fast immune response

MICRONUTRIENT DEFICIENT HOST

Slow immune response

Strong adaptive immunity

Weakened adaptive immunity

Healthy metabolism – Antiviral environment

Oxidative stress – pro-viral environment

• Can nutrients help in fighting the virus? It is a well-established fact that good nutrition forms the basis of healthy immunity. Multiple nutrients are essential to support all immune functions, including forming a barrier to keep microbes from entering the body, and recognizing and identifying harmful pathogens and eliminating them. These functions involve destructive actions by various types of immune cells (white blood

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cells), which are constantly produced in our body. In addition, the immune system generates an immunological memory, so that if we experience re-exposure to a harmful microbe, the immune response is more rapid and stronger than it was to the original challenge. The immune response is commonly classified as either “innate” (natural) or “acquired” (adaptive) immunity.

PA T H O G E N S

Physical & physiological barriers Skin Mucous membranes Body temperature pH

Innate immunity

Adaptive immunity T helper cell

Neutrophils Basophils Eosinophils

Cytotoxic T cells

Macrophages

Naive B cells

Mast cells Dendritic cells Natural Killer cells

These complex and sophisticated functions of our immune system require a coordinated interaction of many organs, and involve var-

Plasma cells

ious cell types, the production and function of which depend on the optimum daily supply of nutrients.

OUR IMMUNE SYSTEM NEEDS NUTRIENTS FOR MULTIPLE METABOLIC PROCESSES SUCH AS:  Energy generation for the entire immune system (macro- and micronutrients)  Synthesis of RNA and DNA and the production of proteins (antibodies, cytokines, receptors, acute phase proteins etc.) and new cells  To regulate immune cell metabolism (e.g. vitamin A, zinc).  Specific antibacterial or antiviral functions (e.g. vitamin D, zinc).  To protect the host from oxidative and inflammatory stress (e.g. vitamin C, vitamin E, zinc, selenium, long-chain omega-3 fatty acids and many plant polyphenols).  Substrates for the intestinal microbiota

Nutrition and COVID-19 Poor nutrition increases susceptibility to infections and permits those infections to become more severe, even fatal. This may be one of the explanations for the higher risk and more severe outcomes from SARSCoV-2 infection seen in the elderly, in people with other diseases, in those on multiple medications, in smokers, and in people exposed to stress and other conditions, all of which have been associated with micronutrient deficiencies.

It is not one, but a complex of various micronutrients that plays a vital role in supporting our immune response, such as vitamins A, C and D, and zinc, copper and iron, as well as B vitamins, vitamin E, vitamin K, selenium, magnesium, various active components in plants, and many others. Deficiencies of these micronutrients impair many aspects of both innate and acquired immunity and increase susceptibility to infections. Such immune impairments can be reversed by nutrient repletion. In fact, older people with a high micronutrient intake and status show much lower immune decline than those with a low intake.

• Are there specific nutrients effective in fighting COVID19? Since the outbreak of COVID-19, various scientific groups have got involved in searching for natural compounds that can inhibit a critical step of viral infectivity, namely the binding of

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the SARS-CoV-2 spike protein to cellular ACE2 receptors. Also, the benefits of vitamin C, D and zinc as essential nutrients for immune system function have been widely investigated and clinically applied.

 Vitamin C supports the activity of the immune cells and can directly interfere with the life cycle of viruses and other pathogens. It can decrease ACE2 cellular receptors and reduce secretion of inflammatory mediators. Our body does not produce vitamin C, so it must be obtained from the diet or supplements.  Broccoli extract is a source of sulforaphane, known for its antiviral, antibacterial, antioxidant, anti-inflammatory and detoxification properties.  Quercetin is a strong antioxidant with anti-inflammatory properties and is important for healthy lung function. It also enhances absorption of resveratrol.  Black tea extract has multiple health benefits, including blocking the binding of the virus to cellular receptors.  Curcumin is known for supporting optimum immunity and suppressing many inflammatory factors.

 Baicalin has been used in Eastern medicine for more than 1,000 years for its multiple health benefits, including antiviral, antimicrobial and antioxidant effects, protecting against free radicals and toxins.  N-acetyl-cysteine (NAC) is a sulfurcontaining amino acid that, among other functions, is necessary for the formation of a powerful antioxidant, glutathione. NAC is important for optimum lung health and function.  Naringin is a beneficial compound found in grapefruit peel, and works synergistically with vitamin C to support cellular defenses.  Resveratrol is a polyphenol synthesized by plants in response to injury, ultraviolet irradiation and microbial attacks. While it is commonly known for its anti-aging properties, its health benefits include antiviral, anti-inflammatory and lung-protective effects.

Nutrition and COVID-19 While all these studies focused on individual components, our research at the DRRI aimed at developing a universal approach to stop coronavirus infection in its multiple steps, including blocking cellular entry of viruses, and their multiplication and spread in cells, as well as inhibiting damaging symptoms of coronavirus infection, such as excessive inflammation.

black tea extract, turmeric (curcumin), baicalin, N-acetyl cysteine (NAC), naringenin and resveratrol can simultaneously inhibit key mechanisms of the SARS-CoV-2 life cycle. What is more, this nutrient mixture was also effective in curbing cellular entry of different variants, including Alpha, Beta, Delta, Gamma, Kappa and Mu. Work on the Omicron variant is pending.

Our published scientific studies (https:// www.dr-rath-education.org/covid-19) document that a nutrient composition containing vitamin C, broccoli extract, quercetin,

Each of the components in this mixture displays multiple health benefits and as a team, all have enhanced efficacy.

• Which nutrients can support my immune system? Good nutrition is especially important for supplying our body with optimum amounts of micronutrients. These are the catalysts of a multitude of metabolic reactions that mount an effective immune response, including the

synthesis and function of immune cells that recognize and engulf pathogens and produce an antibody response. The following are among the most critical nutrients shown to benefit healthy immunity:

 Vitamin C is important for the activity of immune cells, and is required to repair and regenerate collagen, a critical component of the body’s natural barriers. It also has anti-inflammatory effects; it can decrease expression of ACE2 cellular receptors, and its intravenous application showed significant clinical benefits in COVID-19 patients.  Vitamin C combined with  folic acid, and vitamins B6 and B12 can support the development and optimal function of immune cells as well as healthy blood regeneration.  Vitamin E, lipoic acid, zinc and selenium are important for the protection of cells against oxidative damage. 22.

 Fucoidan, a sulfated polysaccharide from brown algae, has been widely researched in the field of immunology, thanks to it having a variety of immune-modulatory effects.  Various polyphenols, such as extracts from lychees, tart cherries, aronia berries and ginger have multiple benefits for the immune system. • How can I protect myself against infections? The cellular health approach to optimum immunity involves many elements, all of which are required for achieving this goal. These elements include maintaining personal hygiene (frequent handwashing), avoiding crowded and poorly ventilated

indoor spaces, daily physical activity, exposure to fresh air, avoiding or managing stress, a healthy, organic diet and daily micronutrient supplementation. These basic elements are important at any age.

• Why do we not hear about natural approaches to COVID-19? The results of our scientific studies with natural compounds, documenting their efficacy against SARS-CoV-2 and its variants, have been presented in several scientific publications. In addition, our scientific expertise, and the offer of our cooperation in developing effective measures against

COVID-19 using natural, economic means, were directly communicated to heads of state and health officials, and presented to the media in many countries, so none of them can say that they did not know about it. These communications appeared at a time when the world had been and still © Dr. Rath Health Foundation 23.

Nutrition and COVID-19 is seeking effective solutions to COVID-19. Why haven’t you heard about it? Why are natural approaches either ignored or deemed ineffective? We all know the answer: natural, non-patentable solutions are not highly profitable and are in a direct competition with pharmaceutical medicine. In many cases natural approaches can replace drugs, but more importantly, since many diseases stem from micronutrient deficiencies, micronutrient supplementation can eliminate the underlying causes of many diseases. Since the implementation of natural health threatens the economic expansion of pharmaceutical markets, there is no interest in

promoting or funding research and clinical studies with natural compounds. Our Institute in California has been a source of many breakthrough findings with important implications for your health. We could do this only because we use our profits to fund this research. Why do other supplement companies not do this? In the current situation, the dangers of an expanding COVID-19 pandemic, with new viral mutations, call for effective measures beyond the vaccines and masks that would prioritize health benefits over business profits and political gains.

• Basic elements of the universal COVID-19 approach A universal approach to COVID-19 should expand beyond vaccines and pharmaceutical therapies. Preventive measures should include micronutrient supplementation, made available and financially supported by government funds to all individuals, especially those at high risk of specific nutrient deficiencies, the elderly, adolescents, and people suffering from various diseases or obesity. Micronutrient supplementation in children, young and elderly populations is an effective and economic measure to 24.

support the efficacy of the immune system against potential infection. COVID-19 therapies should include evaluation of the nutritional status of patients before administering any conventional treatment, and nutritional supplements should be given to affected individuals as an integral part of the therapy. As such, in addition to a science-tested micronutrient program, intravenous vitamin C, which has shown clinical benefits in severely infected COVID-19 patients, should be applied.

Important Elements of an Anti-COVID Approach: • Effective in preventing clinical disease • Prevents infection caused by viral recombination variants • Supports robust immune response and lifelong systemic immunity • Does not limit efficacy in persons with pre-existing immunity • Efficacy should be lasting in persons with immunosuppression • Induces immunity to multiple viral components, not only the spike protein, and targets critical steps in the viral life cycle • Is safe and acceptable to the public • Is safe for pregnant women • Can be used in persons of all ages • Is affordable

Dr. Rath Research Institute -- Relevant Publications Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants. Goc A, Niedzwiecki A, Ivanov V, Ivanova S, Rath M. Eur J Microbiol Immunol (Bp). 2022;11(4):87-94. DOI: https://doi.org/10.1556/1886.2021.00022 (Available at: https://akjournals.com/view/journals/1886/ 11/4/article-p87.xml) Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds. Goc A, Ivanov V, Ivanova S, Chatterjee M, Rath M, Niedzwiecki A. Eur J Bio Biotech 2021;2(5) DOI: http://dx.doi.org/10.24018/ejbio.2021.2.5.258 (Available at: https://ejbio.org/index.php/ejbio/article/view/258) Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions. Goc A, Sumera W, Rath M, Niedzwiecki A.PLOS ONE 2021;16(6):e0253489 DOI: https://doi.org/10.1371/journal.pone.0253489 (Available at: https://journals.plos.org/plosone/ article?id=10.1371/journal.pone.0253489) Inhibition of ACE2 expression by Ascorbic acid alone and its combination with other natural compounds. Ivanov V, Goc A, Ivanova S, Niedzwiecki A, Rath M. Infect Dis (Auckl) 2021;14:1178633721994605. DOI: https://doi.org/10.1177/1178633721994605 (Available at: https://journals.sagepub.com/ doi/10.1177/1178633721994605) Scientific basis of micronutrient applications as an effective, safe, and affordable global public health strategy to help control the coronavirus pandemic. Niedzwiecki A, Rath M. J Cellular Medicine and Natural Health 2021, January.(Available at: https://jcmnh.org/index.php/2021/01/19/scientific-basisof-micronutrient-applications-as-an-effective-safe-andaffordable-global-public-health-strategy-to-help-controlthe-coronavirus-pandemic) The micronutrient combination with immuneenhancing effects. Sumera W, Goc A, Niedzwiecki A, Rath M. J Cellular Medicine and Natural Health 2020, August (Available at: https://jcmnh.org/index.php/2020/ 08/28/the-micronutrient-combination-with-immuneenhancing-effects) 26.

Micronutrient combination inhibits two key steps of coronavirus (SARS-CoV-2) infection: viral binding to ACE2 receptor and its cellular expression. Goc A, Sumera W, Ivanov V, Niedzwiecki A, Rath M. J Cellular Medicine and Natural Health 2020, August (Available at: https://jcmnh.org/index.php/ 2020/08/14/micronutrient-combination-inhibits-two-keysteps-of-coronavirus-sars-cov-2-infection-viral-binding-toace2-receptor-and-its-cellular-expression) Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient composition inhibits Coronavirus cell-entry receptor (ACE2) expression. Ivanov V, Ivanova S, Niedzwiecki A, Rath M. J Cellular Medicine and Natural Health 2020, July (Available at: https://jcmnh. org/index.php/2020/07/02/effective-and-safe-globalpublic-health-strategy-to-fight-the-covid-19-pandemicspecific-micronutrient-composition-inhibits-coronaviruscell-entry-receptor-ace2-expression)

Select publications from other research institutions: SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Hui Jiang, Ya-Fang Mei. Viruses, 2021 Oct 13;13(10):2056. DOI: 10.3390/v13102056 Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Jing Zhang et al., Ann. Intensive Care (2021) 11:5, DOI: https://doi.org/10.1186/s13613-020-00792-3 The epidemiological relevance of the COVID-19vaccinated population is increasing. Gunter Kampf; The Lancet Regional Health - Europe, 11 (2021), 100272 DOI: https://doi.org/10.1016/j.lanepe.2021.100272 Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed. Gloria Shwe Zin Tun et al., J Hepatology, Published October 04, 2021, DOI: https://doi.org/10.1016/j.jhep.2021.09.031

researchers Dr. Anna Goc Dr. Goc leads the Microbiology Laboratory working on developing effective and safe approaches to controlling infections. She has wide-ranging knowledge in the fields of microbiology, immunology, cancer, and vascular biology. Her research work has been published in numerous scientific journals and honored by national and international awards and patents.

Dr. Vadim Ivanov Dr. Ivanov holds a medical degree from Tomsk Medical Academy in Tomsk, Russia and doctorate degree in Biochemistry from the National Cardiology Center in Moscow, Russia. He and his team at the Dr. Rath Research Institute have been conducting scientific studies on the benefits of micronutrients in important aspects of health, such as cardiovascular disease, infectious diseases and various metabolic disorders. The results of these studies were featured in numerous publications and granted national and international patents. W. Sumera, M.Sc. Waldemar Sumera graduated from the Jagiellonian University in Cracow, Poland. At the Dr. Rath Research Institute he is engaged in microbiology research focused on the application of natural compounds in controlling cellular mechanisms affected by bacterial and viral infections.

Dr. Aleksandra Niedzwiecki Currently the Director of Research at the Dr. Rath Research Institute, Dr. Niedzwiecki is a leading biomedical researcher in the development of nutrient synergy approaches in various aspects of health and disease. Her work in the areas of cardiovascular health, cancer and infections has won her recognition for her research into the biochemical link between disease and nutrients.

Dr. Matthias Rath Dr. Rath is a world-renowned physician and scientist known for his pioneering research in natural and cellular health. He is the founder of the scientific concept of Cellular Medicine – the systematic introduction into clinical medicine of the biochemical knowledge of the role of micronutrients as biocatalysts in a multitude of metabolic reactions at the cellular level.

Disclaimer: This booklet is not intended as a substitute for the medical advice of a physician. The reader should regularly consult a physician in matters relating to his or her health and particularly in respect to any symptoms that may require diagnosis or medical attention.

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