Chemical Heritage Foundation Innovation Day 2015 Program Book

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INNOVATION DAY OCTOBER 5–6

Where early-career scientists and industry leaders consider solutions to society’s most pressing needs.

PREMIER SPONSOR

The Warren and Katharine Schlinger Foundation MAJOR SPONSORS

Chemtura Corporation The Dow Chemical Company DuPont Eastman Chemical Company ExxonMobil Chemical Company

2015

W. R. Grace & Co. CONTRIBUTING SPONSORS

American Air Liquide, Inc. Arkema Dow Corning Corporation LyondellBasell Industries

STEERING COMMITTEE

Rob Crane Global Chemical Research Manager, ExxonMobil Chemical David Myers Vice President of Technology of Marketing, W. R. Grace and Company Nilesh Shah Director of Global R&D for the Home and Personal-Care Business, Dow Chemical Company Ian Shankland Vice President and Chief Technology Officer, Honeywell David Sikora (Committee Chairperson) Director, Global Technology, Chemtura, Inc. Albert Tam Global Technology Leader, DuPont Sustainable Solutions Daniel White Manager of R&D, Acetyls, BDO, and Olefins Research, Lyondell Chemical Company

About Innovation Day In an age of increasing interconnectivity and complexity in the chemical industries, successful innovators connect face-to-face with their peers and look beyond immediate technical matters to understand the broader implications of their work. In taking early-career scientists out of the lab and introducing them to their peers, to industry leaders, and to the historical and social context of their research, Innovation Day supports a 21st-century chemical enterprise that addresses society’s most pressing needs.

Innovation Day is jointly organized by the Chemical Heritage Foundation (CHF) and the Society of Chemical Industry (SCI) America International Group. The annual event includes the Warren G. Schlinger Symposium and the awarding of the SCI Gordon E. Moore Medal, the only award of its kind, presented each year to an early-career researcher who has achieved market success. The Schlinger Symposium is the core of Innovation Day, bringing together promising young scientists and seasoned technology leaders from across the chemical industries with a focus on the frontiers of chemical R&D. Plenary, breakout, and poster sessions highlight areas where the chemical industry interfaces with other emerging business sectors. The symposium offers participants the opportunity to learn about cutting-edge science and technology, exchange ideas with peer industrial researchers and entrepreneurs, and prepare to be the innovators and leaders of the next generation.

CONTENTS Schedule 2–5 Map 4–5 Breakout Sessions

6–7

Speakers and Moderators

8–14

2015 SCI Gordon E. Moore Medalist

15

About the Gordon E. Moore Medal

15

Past SCI Gordon E. Moore Medalists

15

About Gordon E. Moore

16

About the Premier Sponsor

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Schedule MONDAY, OCTOBER 5 3:00−4:00 p.m.

Innovation Day Pre-Session “Science at Play” Franklin I and II, Conference Center at CHF, 2nd Floor

MODERATOR: Jody Roberts, Director of the Institute for Research, CHF

SPEAKER: Erin McLeary, Museum Director, CHF

4:00−5:00 p.m.

Break The Museum at CHF will be open until 5:00 p.m. for self-guided tours.

5:00−6:00 p.m.

Opening Reception Jacobs Reading Room, 3rd Floor

6:00−8:30 p.m.

Dinner and Evening Plenary Address Ullyot Meeting Hall, 1st Floor

TITLE OF TALK: From Play to Innovation

SPEAKER: Neil Stevenson, Executing Portfolio Director, IDEO Chicago

TUESDAY, OCTOBER 6 7:30 a.m.

Speakers’ Breakfast Jacobs Reading Room, 3rd Floor

8:00 a.m.

Continental Breakfast Ullyot North, 1st Floor

8:30−9:25 a.m.

Schlinger Symposium Opening Plenary Address Ullyot Meeting Hall, 1st Floor

SPEAKER: Vijay Kumar, Nemirovsky Family Dean of Penn Engineering, University of Pennsylvania

9:30−11:00 a.m.

Breakout Sessions Conference Center at CHF, 2nd Floor

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— INFORMATION SCIENCE MEETS MATERIALS SCIENCE MODERATOR: David Myers, Vice President, Technology of Marketing, W. R. Grace and Company

SCHEDULE

SPEAKERS: Nathan Tregger, Senior Research and Development Engineer, W. R. Grace and Company

Dale Bentz, Chemical Engineer, Materials and Structural Systems Division, National Institute of Standards and Technology

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LOOKING TO NATURE MODERATOR: David Sikora, Director, Global Technology, Chemtura, Inc.

SPEAKERS: Steven Little, Chairman, Department of Chemical and Petroleum Engineering, University of Pittsburgh

Shu Yang, Professor of Materials Science and Engineering and Chemical and Biomolecular Engineering, University of Pennsylvania

— MAKING WEARABLES FROM NEW MATERIALS MODERATOR: Dan White, Manager of R&D, Acetyls, BDO, and Olefins Research, Lyondell Chemical Company

SPEAKERS: Chi Hwan Lee, Assistant Professor, Weldon School of Biomedical Engineering and School of Mechanical Engineering, Purdue University

Juan Hinestroza, Associate Professor of Fiber Science and Director of Graduate Studies, Cornell University

11:00 a.m.−12:15 p.m.

Poster Session Dow Public Square, 3rd Floor

COORDINATOR: Nilesh Shah, Director, Global R&D for the Home and Personal-Care Business, Dow Chemical Company

PRESENTERS: Katie Faber, Dow Chemical Company Rajatesh Gudibande, GraphWear Technologies Mark Guidry, DuPont Chris Highly, University of Pennsylvania Yijian Lin, Dow Chemical Company Helen Minsky, University of Pennsylvania Tamás Prileszky, University of Delaware Teresa Rapp, University of Pennsylvania Nigel Reuel, DuPont Kevin Vargo, Dow Chemical Company INNOVATION DAY 2015

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12:15−2:00 p.m.

SCI Gordon E. Moore Medal Ceremony and Luncheon Ullyot Meeting Hall, 1st Floor

AWARDEE: John A. McCauley, Director of Medicinal Chemistry, Merck Research Laboratories

2:30−4:00 p.m.

Breakout Sessions Conference Center at CHF, 2nd Floor

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ADDITIVE MANUFACTURING AND 3D PRINTING MODERATOR: Nilesh Shah, Director, Global R&D for the Home and Personal-Care Business, Dow Chemical Company SPEAKER: Jan Baum, Executive Director of 3D Maryland, Consultant for Jan Baum and Associates LLC, and Director of the Object Lab at Towson University

1st Floor

2nd Floor: Conference Center at CHF

1 Ullyot Meeting Hall

4 Garden Room 1

2 Elevators to 3rd and

5 Garden Room 2

6th floors

7 Franklin Meeting Rooms 8 O. Röhm & O. Haas

6 Garden Room 3

Meeting Room

3 Museum at CHF

7

6 5

Lounge

4

2 1 Museum at CHF

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Lobby

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— USING NATURE MODERATOR: Rob Crane, Global Chemical Research Manager, ExxonMobil Chemical

SPEAKER: E. Terry Papoutsakis, Eugene DuPont Professor of Chemical Engineering, University of Delaware

— SENSIBLE CLOTHING MODERATOR: Albert Tam, Global Technology Leader, Clean Technologies, DuPont

SPEAKERS: Jesse Jur, Assistant Professor of Textile Engineering, Chemistry, and Science, North Carolina State University

Steven Willoughby, Global Segment Leader, DuPont

4:00−5:00 p.m.

Closing Reception and Museum Tours

SCHEDULE

Overlook Lounge, 2nd Floor

3rd Floor

6th Floor

9 Dow Public

11 Room 603

Square 10 Jacobs Reading Room

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BREAKOUT SESSIONS Information Science Meets Materials Science: The Role of Big Data in Materials Research The science of designing new materials has always been immersed in information and data. But how are breakthroughs in our ability to generate and process larger data sets—Big Data—merging with new material research and engineering? In this session panelists will discuss the ways in which our ability to gather and process data is changing how new and traditional materials are being developed and used, with special attention to the application of construction and building materials.

Looking to Nature: Biological Models for Chemical Processes and Products Differentiation more than ever is a key success factor in the chemical industry today. The only truly sustainable differentiator is innovation: that is, the creation of an idea and the implementation of that idea for a new product, new process, or process improvement, or for the solving of a technical problem. Many studies have shown that these seeds of innovation (ideas and discoveries) are very often sown at the intersection of different disciplines. In this breakout session we will experience the confluence of biology, chemistry, physics, and engineering and the innovations thereof. For example, Mother Nature has provided insight for a wide range of innovations: new armor from Amazonian fish, aerospace materials from ragworms, robotic vision based on insect eyes, and new concepts for cleaning microelectronics inspired by ant antennae. Our speakers in this session, Shu Yang of the University of Pennsylvania and Steven Little of the University of Pittsburgh, will discuss their bio-inspired research and will no doubt inspire us to take a new look at how we may innovate.

Wearing Smart: Making Wearables from New Materials Breakthroughs in materials for clothing and apparel used to mean replacing old technologies such as cotton with new synthetic materials to perform better—wicking moisture and cutting the weight of the material. Today’s new materials blend this long tradition of textile engineering with emerging research from nanoscale science and engineering to build new wearable materials.

These new materials do not simply outperform their predecessors; they provide novel functionality in the form of embedded electronics and biosensors and new production techniques that allow for rapidly produced customizable apparel. Speakers in this session will explore the ways in which old technique merges with new technology and the possible futures for smart clothing.

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Additive Manufacturing and 3D Printing: Building from the Bottom Up How are changes in the technology of additive manufacturing and 3D printing being leveraged for the production and assembly of individual chemicals? Over the course of the last decade these technologies have evolved from boutique fun and demonstration product creation to an emerging and still evolving set of tools for manufacturing and producing chemicals in bulk.

While much of the technology is still being developed, the implications for the chemical sector could be significant. Speakers in this session will focus on some of the latest technologies and techniques and discuss some possible paths to integration into the chemicals market.

Using Nature: Putting Biology and Biological Processes to Work The boundary between the biological and the chemical has become increasingly blurred in recent years. Significant changes are under way that continue this trend. Where the biological once stood as model or feedstock for chemical processes, biological organisms and processes are now being designed and mobilized to carry out these processes on their own. Speakers in this session will discuss trends in this area of R&D and specific ways in which these new technological platforms are being put to use in the world of chemical processing.

Sensible Clothing: Embedding Sensor Technologies in Apparel Advances in sensor development, remote communication, and design and production are creating a new generation of wearable technologies. These devices monitor our bodies and our environments, making what is knowable, and when, an evolving parameter in how we engage with the world around us. Making use of these devices—and the information they can provide—is a continuing challenge. Speakers in this session will address directions for developing these technologies, applications of embedding sensors into everyday objects, and the possibilities these technologies have for changing the nature of information, communication, and energy.

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SPEAKERS AND MODERATORS

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INNOVATION DAY 2015

Jan Baum

Dale Bentz

A leader in the 3D printing and additive

Dale Bentz is a chemical engineer in the Materials and

manufacturing industry, Jan Baum is leading the

Structural Systems Division of the Engineering Laboratory,

charge in building a 21st-century 3DP/AM industry in

National Institute of Standards and Technology. For the

Maryland and the Mid-Atlantic region. Baum facilitates

past 30 years he has performed research on construc-

a connected and collaborative rapid technology

tion materials, including protective coatings, fire-resistive

ecosystem across sectors; has instituted industry

materials, and cement and concrete. He is a member of

best practices for Maryland; has established multiple

the American Concrete Institute and committees C01

innovation and prototyping labs to educate future

(honorary member), C09, and E37 of ASTM Interna-

workforce leaders and help businesses compete using

tional. He serves as an associate editor of the journal

3DP/AM technologies; educates high-level audiences;

Cement and Concrete Composites. He has contributed

and works to strengthen the region’s economy

to over 300 technical publications in refereed journals,

through jobs resulting from the use of 21st-century

conference proceedings, and book chapters since 1984.

advanced manufacturing technologies. These efforts

Bentz holds master’s degrees in both

have been recognized through numerous awards,

computer science and teaching and a BS in chemical

including the Daily Record’s Influential Marylanders

engineering.

2014, the Daily Record’s Innovator of the Year 2013 and 2014, the Economic Alliance of Greater Baltimore’s Rock Star Series 2012, and a Smart CEO

Rob Crane

Voltage Award finalist in 2012 and 2014.

Rob Crane is global chemical research manager for

Baum is the founder of Object Lab @ Towson

ExxonMobil Chemical in Baytown, Texas. He has been

University and 3D Maryland, an innovative model for

with ExxonMobil (and previously Mobil) for 19 years.

economic development. She is currently the executive

Trained in catalysis, he worked in exploratory research

director of the 3D Innovation Institute, a principal at J.

and then followed his interests through numerous and

Baum and Associates LLC, and a full professor at Towson

diverse positions in R&D, engineering, manufacturing,

University specializing in emerging technologies, innova-

and management. Crane’s assignments have included

tion, entrepreneurship, and design thinking.

roles as refinery technical manager, director of process

She received an MFA from the University of Massachusetts, Dartmouth, and a BFA from Arcadia University, Glenside, Pennsylvania

and emerging technologies, and strategy and planning executive.

Crane is an inventor on more than 15 U.S. patents and has successfully commercialized two major technologies based on his inventions. He is a member of the American Chemical Society, Sigma Xi Research Society, American Institute of Chemical Engineers, and Purdue Chemical Engineering Industrial Advisory Committee.

Crane holds a PhD in chemical engineering from Purdue University and a BS in chemical engineering from Cornell University.

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SPEAKERS AND MODERATORS Juan Hinestroza

Jesse Jur

Juan Hinestroza is a tenured associate professor of

Jesse Jur is an assistant professor of textile engineering,

fiber science and directs the Textiles Nanotechnology

chemistry, and science at North Carolina State

Laboratory at the College of Human Ecology of Cornell

University’s College of Textiles. He has spent over 12

University. Before pursuing doctoral studies he worked

years researching primarily at the nanoscale, including

as a process control engineer for the Dow Chemical

experiences in the semiconductor and opto-electronics

Company. Hinestroza works on understanding

industries. His current research focuses on integration

fundamental phenomena at the nanoscale that are

of systems electronics into wearable platforms for

of relevance to fiber and polymer science.

energy harvesting and monitoring of a person’s

Hinestroza, a Fulbright Scholar, has been the recipient of a myriad of awards, including the National Science Foundation CAREER Award, the

environmental and physiological state.

He received a PhD in materials science and engineering from North Carolina State University.

J. D. Watson Young Investigator Award from NYSTAR, and the Educator of the Year Award from the Society of Professional Hispanic Engineers. He has delivered

Vijay Kumar

invited lectures worldwide at universities and research

Vijay Kumar is the Nemirovsky Family Dean of Penn

centers. Hinestroza has also received visiting scientist

Engineering at the University of Pennsylvania.He has

fellowships from the Chubu Foundation for Science

been on the faculty in the Department of Mechanical

and Technology of Japan, the National Council for

Engineering and Applied Mechanics with a secondary

Scientific and Technological Development in Brazil,

appointment in the Department of Computer and

and the Swiss National Science Foundation.

Information Science at the University of Pennsylvania

He obtained a PhD from the Department of

since 1987. His research interests lie in the area

Chemical and Biomolecular Engineering at Tulane

of robotics, specifically multirobot systems and

University and a BSc in chemical engineering from

microaerial vehicles.

Universidad Industrial de Santander.

Kumar is a fellow of the American Society of Mechanical Engineers, a fellow of the Institution of Electrical and Electronic Engineers, and a member of the National Academy of Engineering. He is the recipient of the National Science Foundation Presidential Young Investigator award, the Lindback Award for Distinguished Teaching (University of Pennsylvania), the Freudenstein Award for significant accomplishments in mechanisms and robotics, the ASME Mechanisms and Robotics Award, the IEEE Robotics and Automation Society Distinguished Service Award, a World Technology Network Award, and an Engelberger Robotics Award.

Kumar received a PhD from Ohio State University and a bachelor’s of technology degree from the Indian Institute of Technology, Kanpur.

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INNOVATION DAY 2015

Chi Hwan Lee

Steven Little

Chi Hwan Lee is an assistant professor at the Weldon

Steven Little is chairman of the Department of Chem-

School of Biomedical Engineering and School of

ical and Petroleum Engineering and a professor of

Mechanical Engineering at Purdue University. His

chemical and petroleum engineering, bioengineering,

research focuses on the additive nanomanufacturing

pharmaceutical sciences, immunology, and ophthal-

process for flexible, stretchable, and biodissolvable

mology at the McGowan Institute for Regenerative

devices for broad applications in energy systems,

Medicine at the University of Pittsburgh. His research

nanoelectronics, and biomedical devices. Before

has resulted to date in just under 70 peer-reviewed

joining Purdue University he worked as a postdoctoral

publications, 3 book chapters, 4 U.S. patents, 3 U.S.

research associate in John A. Rogers’s group in the

patents pending, and the founding of a spin-out com-

Department of Materials Sciences and Engineering at

pany in Pittsburgh.

the University of Illinois, Urbana-Champaign.

Little has been recognized with numerous

He received MS and PhD degrees in mechanical

national and international awards, including the

engineering from Stanford University and BS degrees

Curtis W. McGraw Research Award from the ASEE,

from both the Illinois Institute of Technology and

the Society for Biomaterials’ Young Investigator

Ajou University, with a dual major in mechanical and

Award, and the University of Pittsburgh’s Chancellor’s

industrial engineering.

Distinguished Research Award. He has also been elected as a fellow of BMES and to the Board of Directors of the Society for Biomaterials, named a Camille Dreyfus Teacher Scholar, and named an Arnold and Mabel Beckman Young Investigator. Little has been recognized by the press, having been named one of Pittsburgh Magazine’s “40 under 40,” a “Fast Tracker” by the Pittsburgh Business Times, and one of only five individuals in Pittsburgh who are “reshaping our world” by Pop City Media.

Little received his PhD in chemical engineering from the Massachusetts Institute of Technology and his BE in chemical engineering from Youngstown State University.

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SPEAKERS AND MODERATORS David Myers

E. Terry Papoutsakis

David F. Myers is the vice president of technology and

Since 2007 E. Terry Papoutsakis has been Eugene

marketing for the specialty construction chemicals

DuPont Professor in the Department of Chemical

business of W. R. Grace and Company. He rejoined

and Biomolecular Engineering at the University of

Grace in 2014 after spending 10 years at RTI

Delaware. He started his academic career at Rice

International, first as vice president of the engineering

University before moving to Northwestern University,

and technology unit and later as the vice president

where he was eventually appointed as Walter P.

and chief technology officer of the discovery-science-

Murphy Professor.

technology business. His career began with 16 years in several R&D roles at Grace.

Papoutsakis’s group has made important contributions in the areas of clostridia genetics and

Myers is a member of the American Chemical

metabolic engineering, animal-cell biotechnology, and

Society and the American Institute of Chemical

stem-cell bioengineering. He is widely recognized as

Engineers, has served as a member of the Governor’s

a leader in metabolic engineering of the industrial

Task Force on Nanotechnology and North Carolina’s

anaerobes clostridia as well as in genome engineering.

Economy, and is a former member of the Cleaner

His lab is interested in developing strains of industrial

Fossil Fuel Systems Committee of the World Energy

importance in the biorenewables arena. Most

Council. He is a founder of the Research Triangle

recently, he has been working on technologies to

Energy Consortium and has served as an observer to

convert natural gas and methanol to chemicals and

the Board of Directors at three technology startups:

liquid fuels using biological processes. He has trained

Avantium Technologies, Nextreme Thermal Solutions,

more than 65 PhD, 27 MS, 32 postdoctoral, and

and siXis Inc. He has served on the board of the

55 undergraduate students. His research has been

National Advanced Biofuels Consortium and the

funded by over $35 million in grants from various

Energy Frontier Research Center on Solar Fuels and

government agencies. He has published over 250

Next Generation Photovoltaics at the University of

papers, which have received almost 13,000 citations

North Carolina.

with an h factor of 69.

Myers has a PhD in chemical engineering,

He received his MS degree and PhD from

with degrees from the Massachusetts Institute of

Purdue University and his undergraduate education

Technology and Princeton University.

at the National Technical University of Athens, Greece.

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INNOVATION DAY 2015

Nilesh Shah

David Sikora

Nilesh Shah is the senior R&D director for the home,

David J. Sikora is the global chemical technology

institutional, and personal-care solutions business of

director of Chemtura’s Great Lakes solutions and

The Dow Chemical Company. He is also the leader for

industrial performance products business segments,

Dow’s Spring House and Northeast Technical Centers.

which includes petroleum additives, urethanes, and

After joining the Rohm and Haas Company in

brominated products and flame retardants. He joined

1985 as a research scientist for the plastics business,

Chemtura in 1997 after 17 years with Monsanto

he held positions of increasing responsibility in

Company in St. Louis, Missouri, and Akron, Ohio,

research management, leading polymer synthesis and

where he led new product and process groups,

exploratory polymer research. From 1999 to 2002

application labs, and technical service for businesses

Shah held commercial roles in the architectural and

that are now owned by Eastman.

functional coatings business, with responsibility for

His areas of technical expertise and experience

strategic planning and marketing. In 2003 he returned

include homogeneous, heterogeneous, and enzymatic

to research as a global technology director. In this role

catalysis, alternate route chemistries for fine, specialty,

he led research and regulatory affairs for the consumer

and commodity chemicals, petroleum additives,

and industrial specialties business followed by the

polymer additives, water-treatment additives, synthetic

process chemicals and biocides business. He made

lubricants, organometallics, electronic chemicals,

the transition to his current role after Dow acquired

and polyurethanes. He also has a vast knowledge

Rohm and Haas in April 2009.

of the worldwide chemical industry in terms of raw

Shah is a member of the American Chemical Society and Tau Beta Pi. He also serves on the Chemical Engineering Advisory Board of the University of Massachusetts, Amherst.

material trees and history of chemical companies via acquisitions and mergers.

He is a strong advocate of and clearly understands the value of connectivity of geographically

Shah graduated with a BS in chemical engi-

separated technology groups for the purpose of find-

neering in 1979 from Jadavpur University in Calcutta,

ing, building on, and implementing new ideas and

India. He then went on to receive his doctorate in

collectively solving problems across the corporation.

chemical engineering from the University of Massa-

Sikora has established and promoted tools and vehicles

chusetts, Amherst.

within Chemtura to institutionalize such connectivity.

He is inventor on 13 patents and the author of 15 publications.

Sikora earned a PhD in organometallic chemistry from the University of Massachusetts, Amherst, and a bachelor’s degree (cum laude) in chemistry from Fairfield University in Fairfield, Connecticut.

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SPEAKERS AND MODERATORS Albert Tam

Steven Willoughby

Albert S. Tam is the global technology leader of

Steven Willoughby is responsible for leading a team

DuPont’s sustainable solutions business, based in

of market segment managers to advance DuPont Mi-

Wilmington, Delaware. Over the past 10 years Tam

crocircuit Materials’ business strategy in the Americas

has led the development and commercialization

and Europe. He has global oversight for his business’s

of sustainable products and processes that have a

work in a number of printed electronics applications.

dramatically lower impact on the environment. In his

He joined DuPont in 1999 and has since held a va-

current role he leads a team developing technology

riety of roles, including global management roles in

solutions that help our customers enhance health

multiple DuPont businesses and functions, spanning

and safety, improve operations efficiency, and

marketing and sales, R&D, operations, engineering,

reduce emissions. These include solutions for clean

environmental management, supply chain, and quality

air, clean fuels, and industrial processes with lower

management. Before joining DuPont, Willoughby was

energy use and higher energy recovery. Before taking

the founder and chief executive officer of an online

on this role Tam held leadership roles in DuPont’s

marketing company. He is a certified Six Sigma Black

chemicals and fluoroproducts business, where he led

Belt and Eagle Scout. Willoughby is based in Research

the process development and commercialization of

Triangle Park, North Carolina.

hydro-fluoro-olefin products, which have zero ozone-

He received an MBA from the Kellogg School

depletion potential and low global-warming potential.

of Management at Northwestern University and a BS

He was part of a team recognized with DuPont’s

in chemical engineering from Drexel University.

Bolton-Carothers Innovative Science Award for “commercializing Opteon YF as the next generation refrigerant for the automotive industry.”

Shu Yang

Since joining DuPont in 1990 Tam has also

Shu Yang is a professor in the Departments of Materi-

held a range of research and leadership positions in

als Science and Engineering and Chemical and Biomo-

the engineering research function, leading research

lecular Engineering at the University of Pennsylvania.

in the areas of fibers, yarns, textiles, thermoplastic

Her research broadly covers synthesis, fabrication, and

composites, process control, materials engineering,

assembly of soft materials with precisely controlled

polymer processing, and polymer nanocomposites.

size, shape, and geometry, and dynamic tuning of their

Tam holds SB, SM, and PhD degrees in mechanical engineering from the Massachusetts Institute of Technology.

size and structures and the resulting unique optical, mechanical, and surface-interfacial properties.

She worked at Bell Laboratories, Lucent Technologies, as a member of the technical staff before joing Penn in 2004. She is a fellow of the National

Daniel White

Academy of Inventors and listed as one of the world’s

Daniel White is the manager of R&D, acetyls, BDO,

top 100 young innovators under age 35 by MIT’s

and olefins research at Lyondell Chemical Company.

Technology Review.

He joined LyondellBasell in 2001 as a research chemist.

Yang received a PhD in chemistry and chemical

White received a PhD from the University of

biology while researching in materials science and

St. Andrew and a BSc in chemistry from the University

engineering at Cornell University and a BS from Fudan

of Nottingham.

University, China.

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INNOVATION DAY 2015

2015 SCI Gordon E. Moore Medalist John A. McCauley is currently working as a director of medicinal chemistry in the field of hepatitis C virus (HCV) protease inhibitor drug design and synthesis at Merck Research Laboratories in West Point, Pennsylvania. HCV infection continues to represent a major health issue, with estimates of 130 million to 170 million people infected worldwide.

Though hepatitis C is slow to progress, the disease ultimately leads to liver damage in up to 50% of affected individuals as well as carcinoma in a significant number of cases. Until 2011 standard treatment for HCV-infected patients was effective about 40% to 50% of the time. The success rate is improving dramatically with the introduction of new protease inhibitors.

Using a molecular modeling approach based on the enzyme crystal structure of HCV NS3 protease, McCauley and his team developed a strategy for macrocyclization of compounds to enhance interaction with the enzyme. To achieve these compounds they designed a new synthetic route for constructing complex 20-membered macrocycles. His skills in design and synthesis led to multiple novel series of compounds with good pharmacokinetics and activity against resistant HCV mutant viruses. His efforts on these series were rewarded with the discovery of Vanihep and grazoprevir, a next-generation compound currently in phase III clinical studies.

Over the past 17 years McCauley and his group have been involved in the design and synthesis of nine compounds entering clinical development, including HCV NS3/4a protease inhibitors and additional compounds from antiviral and neuroscience programs. McCauley has coauthored 37 publications and is an inventor on 23 issued patents and 17 pending patent applications. He is also a frequent guest lecturer who has given 18 invited presentations at national meetings and academic venues.

McCauley earned a BA with honors in chemistry from Swarthmore College in 1991 and a PhD in organic chemistry from the University of Pennsylvania, where he completed the total synthesis of rapamycin in the laboratory of Amos B. Smith III. After working at Harvard University as a National Institutes of Health postdoctoral fellow with Yoshito Kishi, he joined Merck in 1998 as a senior research chemist.

About the Gordon E. Moore Medal The Society of Chemical Industry (SCI), America Section, established the SCI Gordon E. Moore Medal to recognize earlycareer success in innovation, as reflected both in market impact and improvement to quality of life. By highlighting extraordinary individuals and their work, SCI America aims to promote public understanding of research and development in modern chemical industries, enhance the interest of students in applied chemistry by providing role models, and emphasize the role of creative research in the global economy.

Past SCI Gordon E. Moore Medalists Andrew Taggi (2014)

Emmett Crawford (2010)

Jonathan M. McConnachie (2006)

Jerzy Klosin (2013)

Emma Parmee (2009)

Jeffrey John Hale (2005)

Dean Rende (2012)

Edmund M. Carnahan (2008)

George Barclay (2004)

Doron Levin (2011)

Paul A. Sagel (2007) INNOVATION DAY 2015

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About Gordon E. Moore Gordon E. Moore cofounded Intel in 1968. He is widely known for Moore’s law, in which in 1965 he predicted that the number of components the industry would be able to place on a computer chip would double every year. In 1975 he updated his prediction to once every two years. Moore earned a BS in chemistry from the University of California, Berkeley, and a PhD in chemistry and physics from the California Institute of Technology.

He received the Presidential Medal of Freedom, the nation’s highest civilian honor, from George W. Bush in 2002. He received the National Medal of Technology from President George H. W. Bush in 1990.

About the Premier Sponsor Innovation Day’s Schlinger Symposium is named in honor of Warren G. Schlinger, a PhD graduate of the California Institute of Technology with a distinguished career in industrial innovation. In Schlinger’s 35 years at Texaco, he was a pioneer in gasification technologies now widely used for production of hydrogen, other chemicals, and power. Among other benchmarks, Schlinger had 15 U.S. patents issued during his career.

He has been honored with the AIChE Technical Achievement Award and the Chemical Engineering Practice Award, and by the National Academy of Engineering.

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About CHF CHF fosters dialogue on science and technology in society. Our staff and fellows study the past in order to understand the present and inform the future. We focus on matter and materials and their effects on our modern world in territory ranging from the physical sciences and industries, through the chemical sciences and engineering, to the life sciences and technologies. We collect, preserve, and exhibit historical artifacts; engage communities of scientists and engineers; and tell the stories of the people behind breakthroughs and innovations.

About SCI SCI America, launched in 1894, is part of the Society of Chemical Industry’s international organization. It provides a unique networking forum for chemical industry leaders, industrial scientists, and technologists to exchange new business ideas and best practices. It celebrates achievement to promote public awareness of the contributions of industrial chemistry and inspire students to enter technical careers.

SCI America section also offers its members the opportunity to become part of an international network of industry thought leaders and researchers. Through specialized conferences, e-events, and publications, it helps foster best practices in fields as diverse as fine and commodity chemicals, food, pharmaceuticals, biotechnology, agriculture, and environmental protection.

The Perkin Medal was established in 1906 to commemorate the 50th anniversary of the discovery of mauveine. Past recipients include Nobel laureates Glenn T. Seaborg, Carl S. Marvel, and Herbert C. Brown; Donald F. Othmer, chemical engineer; Stephanie Kwolek, inventor of Kevlar; Paul S. Anderson, medicinal chemist; and Gordon E. Moore, the founder of Intel.

INNOVATION DAY

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