Abstract OE-1
THE SYNERGISTIC EFFECT OF RENALASE AND CHRONIC KIDNEY DISEASE ON ENDOTHELIN-1 IN SUBJECTS WITH ESTABLISHED CORONARY ARTERY DISEASE ‒ A CROSS-SECTIONAL STUDY 1
YU-HSUAN LI, 1WAYNE HUEY-HERNG SHEU, 1WEN-JANE LEE, 1CHIA-PO FU, 1 KAE-WOEI LIANG, 1I-TE LEE Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan
Backgrounds. Endothelin-1 (ET-1), released from endothelium, is associated with endothelial dysfunction and vasoconstriction. Increased circulating ET-1 has been reported to be associated with long-term cardiovascular mortality. Renalase, released from kidney, metabolize catecholamines and regulate blood pressure. Increase in circulating renalase has been reported in the subjects with chronic kidney disease (CKD) and to be associated with coronary artery disease (CAD). We hypothesize a synergistic effect of serum renalase and CKD on serum ET-1 in the subjects with CAD. Methods. A total of 342 non-diabetic subjects with established CAD were included in this study. ET-1 and renalase were measured in all subjects after an over-night fasting. Results. The subjects with CKD had higher ET-1 (1.95 ± 0.77 vs. 1.62 ± 0.76 pg/mL, P < 0.001) and renalase (46.8 ± 17.1 vs. 33.9 ± 9.9 ng/mL, P < 0.001) than those without CKD. The subjects with both CKD and high renalase (> median of 36.2 ng/mL) showed highest serum ET-1 (P value for trend < 0.001). Using multivariate linear regression, high serum renalase with CKD is a significant risk for increase serum ET-1 (95%CI = 0.161‒0.645, P = 0.001). Conclusion. There is synergistic effect of high serum renalase and CKD on increase in ET-1 in the subjects with established CAD.
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