40
The
th Annual Meeting of March 30-31, 2019 The Endocrine Society and The Diabetes Association of the R.O.C. (Taiwan)
BP-1
RELATIVE CONTRIBUTION OF BASAL AND POST-PRANDIAL HYPERLGYCEMIA STRATIFIED BY A1C CATEGORIES BEFORE AND AFTER TREATMENT INTENSIFICATION WITH DULAGLUTIDE 1
GUILLERMO UMPIERREZ, 2KEVIN M. PANTALONE, 3CHARLES ATISSO, 3 LAURA FERNÁNDEZ LANDÓ, 3HIREN PATEL, 3THOMAS LEW (NON-AUTHOR PRESENTER) 1
Department of Medicine, Emory University, Atlanta, GA, USA; 2Cleveland Clinic, Cleveland, OH, USA; 3Lilly USA, Indianapolis, IN, USA
Dulaglutide (DU) has demonstrated non-inferiority vs. liraglutide (LIR) and superiority vs. exenatide BID (EXE) in A1c reduction. No data are available on how GLP-1RAs affect the relative contribution of basal hyperglycemia (BHG) and post-prandial hyperglycemia (PPHG) to overall hyperglycemia (OHG) across A1c categories. Data from five phase 3 studies (N = 673) were pooled to assess the change in relative contributions of BHG and PPHG to diurnal OHG across different A1c categories after 6 months of WUHDWPHQW LQWHQVL¿FDWLRQ ZLWK '8 PJ DV PRQRWKHUDS\ RU ZLWK RUDO PHGLFDWLRQ V LQ W\SH GLDEHWHV patients . BHG and PPHG were calculated using the area under the curve of the 7-point SMPG SUR¿OHV 2YHUDOO FKDQJH LQ %+* IRU '8 YV /,5 DQG '8 YV (;( ZDV DVVHVVHG E\ LQGLYLGXDO VWXGLHV At baseline, relative contributions of BHG increased and PPHG decreased with increasing A1c levels which was maintained after 6 months of treatment with DU despite 1.3% overall mean A1c reduction. At 6 months, the relative contribution of BHG and PPHG were similar between LIR and DU. Relative contribution of BHG was 66.7% (DU) and 66.0% (LIR) at baseline and 55.2% (DU) and 55.9% (LIR) at 6 months. Relative contribution of PPHG was 33.3% (DU) and 34% (LIR) at baseline and 44.8% (DU) and 44.1% (LIR) at 6 months. However, DU had lower BHG but higher PPHG contribution than EXE. Relative contribution of BHG was 63.3 (DU) and 63.1 (EXE) at baseline and 44.7% (DU) and 56.5% (EXE) at 6 months (p <0.001). Relative contribution of PPHG was 36.7% (DU) and 36.9% (EXE) at baseline and 55.3% (DU) and at 43.5% (EXE) at 6 months. The trend of relative contribution of PPHG and BHG across A1c categories is similar before and DIWHU '8 WUHDWPHQW LQWHQVL¿FDWLRQ LPSO\LQJ LWV HIIHFW RQ ERWK %+* DQG 33+* WR ORZHU $ F
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