Abstract
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GENETIC DETERMINANTS OF CARDIOMETABOLIC DISEASE PHILIP S. TSAO, PH.D. Professor of Medicine (Cardiovascular Medicine); Stanford University School of Medicine Associate Chief of Staff for Precision Medicine; VA Palo Alto Health Care System Director; VA Palo Alto Epidemiology Research and Information Center (ERIC) for Genomics Co-Principal Investigator; Million Veteran Program
While obesity, type 2 diabetes (T2D) and dyslipidemia are known heritable risk factors for cardiovascular disease, it has only been recently that breakthroughs in measuring genetic variability DV ZHOO DV GHYHORSPHQWV LQ LQIRUPDWLRQ VFLHQFHV KDYH OHG WR WKH LGHQWL¿FDWLRQ RI PDQ\ JHQHWLF ORFL associated with different traits. For many of these loci, the causal variants and the mechanisms of KRZ WKH\ LPSDFW GLVHDVH UHPDLQ XQNQRZQ OLPLWLQJ WKH FXUUHQW WUDQVODWLRQDO YDOXH RI WKHVH ¿QGLQJV ,Q WKLV WDON , ZLOO GLVFXVV WKH EDVLFV RI JHQRPH ZLGH DVVRFLDWLRQ VWXGLHV DQG UHFHQW ¿QGLQJV UHODWHG WR cardiometabolic disease from the largest US-based genetic cohort, the Million Veteran Program.
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